T1DBase focuses on two research areas in type 1 diabetes (T1D): the
genetics of T1D susceptibility and beta cell biology. This site provides
tools which allow scientists to analyze, store, and share this T1D data
with other scientists.
There are two main ways to access information in T1DBase:
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Use the Search box in the upper right corner to search for genes,
genetic markers (SNPs), or candidate regions. The results page
has a summary of each gene, marker, or candidate region that matched
the search term and provides links to pages with more
information. It works best to search for identifiers, such as gene
symbols (e.g., INS or PDX-1), RS numbers for SNPs, and so forth.
T1DBase does not do full text searching.
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Click on a link in the list on the left side of the page
(called the "navigation bar"). Most links point to
pages that provide access to specific kinds of information, for
example, summary information from the Wellcome Trust Case Control
Consortium (WTCCC), or microarray gene expression data from a large
number of studies.
You can also click on the idiogram on the T1DBase home page to see
information about genomic regions identified through genetic
studies. You can click on a chromosome or the colored bars to the
right of each chromosome to obtain further detail on a susceptibility
region. T1DBase has idiograms for human, mouse, and rat; links in
the upper right corner of the idiogram allow you to select which organism
is displayed.
Getting Started with the Navigation Bar
Getting Started
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Overview. An overview of T1DBase that will help you use the site.
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FAQ. T1DBase Frequently Asked Questions. View the FAQ
Genetics
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T1DMart. Query marker and genotype data using positional, genotypic, or subject-related
criteria. More Information
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T1D Regions. Curated regions of interest for T1D and other immune-related diseases.
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T1DGC Meta-analysis. GWAS meta-analysis data.
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WTCCC Summary Data. Access data from the Wellcome Trust Case Control Consortium.
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NOD Strain Information.
Visualize NOD congenic strains.
Genomics
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GBrowse. Genome browser.
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BLAT Search. Search human and mouse T1D susceptibility region
sequence using Kent's BLAT algorithm. More Information
Gene expression
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HaemAtlas Search. Gene expression profiles obtained from the HaemAtlas microarray study of the human haematopoietic system. More Information
General
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Gene Dossier. Concise table view
of a list of genes emphasizing T1D-specific data. More Information
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Connect the Dots.
Translator for biological identifiers. More Information
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Poster Pages. Discussions of
scientific topics by T1DBase staff in collaboration with contributing
scientists. More Information
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My T1DBase. Lists of genes, markers, and candidate regions. More Information
Networks & Pathways
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KEGG Pathways. Lists of genes in KEGG pathways.
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