Human Type 1 Diabetes Loci

A table of Human loci associated with T1D. Cytogenetic bands are defined using data from UCSC genome browser, protein coding and non-coding genes were extracted from EnsEMBL v77. Hits were defined by taking the index variant as described in the listed publication. Starting at the variant of interest, the hit is extended out ±0.1cM. These hits are then merged together to form regions of the genome that are of interest to this disease.

The first column of each region is coloured accordingly; those which have reached genome-wide association in a T1D study (p<5E-08) or have significant association in candidate gene study, and those where there is evidence of pleiotropy with another curated autoimmune disease (p.T1D<1E-05 and p.other<5E-08).

Markers identifiers are shown as they were published. If these markers have subsequently beein assigned a different rs id, either through dbSNP submission or merging, the links have been updated to the new id.

The alleles shown are major allele > minor allele, with the odds ratio being defined for the minor allele. Other signals located in the same region as the primary signal have a pale yellow background and are shown in italics

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The data in the table below are available for download as many different file types (click on the arrow to view them) and also as a PDF File (link to external site - web2pdfconvert).

 
GRCh38
GRCh37
NCBI36
Table as Text
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GFF File Format
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BED File Format
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Variants  
Tab-delimited Format
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GFF File Format
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BED File Format
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Genes  
Tab-delimited Format
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GFF Format
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Older versions of these all region files are available to download from the archive directory.

T1D Regions   Top   Help
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Last updated 14th April 2015 09:29:35.

 
Region
Feature
Location
Markers
Causal Gene Candidate
Immune Diseases