T1DBase Papers of Interest

T1DBase is a Type 1 diabetes (T1D) specific bioinformatics resource. This is an RSS feed from the T1DBase website which allows you to stay up to date with journals of interest from the website. To subscribe to it, you will need a News Reader or other similar device.

Signatures of Environmental Genetic Adaptation Pinpoint Pathogens as the Main Selective Pressure through Human Evolution.

Wed, 14 Dec 2011 09:38:13 GMT

Fumagalli M et al; PLoS Genet. 2011 Nov; 7(11)

The yin and yang of interleukin-2-mediated immunotherapy.

Tue, 6 Dec 2011 16:52:51 GMT

Bluestone JA et al; N. Engl. J. Med. 2011 Dec 1; 365(22)

Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis.

Tue, 6 Dec 2011 16:52:29 GMT

Saadoun D et al; N. Engl. J. Med. 2011 Dec 1; 365(22)

Interleukin-2 and regulatory T cells in graft-versus-host disease.

Tue, 6 Dec 2011 16:51:35 GMT

Koreth J et al; N. Engl. J. Med. 2011 Dec 1; 365(22)

Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice.

Mon, 31 Oct 2011 09:28:20 GMT

Liu SM et al; The Journal of clinical investigation 2011 Oct 24

Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.

Fri, 14 Oct 2011 17:11:35 GMT

Ferreira MA et al; Lancet 2011 Sep 10; 378(9795)

Human metabolic individuality in biomedical and pharmaceutical research.

Fri, 9 Sep 2011 10:59:38 GMT

Suhre K et al; Nature 2011 Sep 1; 477(7362)

Reduced Serum Vitamin D-Binding Protein Levels Are Associated With Type 1 Diabetes.

Fri, 9 Sep 2011 10:58:56 GMT

Blanton D et al; Diabetes 2011 Aug 15

Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.

Mon, 22 Aug 2011 11:52:45 GMT

Rainbow DB et al; J. Immunol. 2011 Jul 1; 187(1)

Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity.

Mon, 22 Aug 2011 11:52:07 GMT

Mohammed JP et al; J. Immunol. 2011 Jul 1; 187(1)

Reducing or increasing β-cell apoptosis without inflammation does not affect diabetes initiation in neonatal NOD mice.

Wed, 13 Jul 2011 09:59:44 GMT

Carrington EM et al; European journal of immunology 2011 Jun 15

How Does Type 1 Diabetes Develop?: The Notion of Homicide or {beta}-Cell Suicide Revisited.

Fri, 3 Jun 2011 17:24:04 GMT

Atkinson MA et al; Diabetes 2011 May; 60(5)

A cluster of coregulated genes determines TGF-{beta}-induced regulatory T-cell (Treg) dysfunction in NOD mice.

Tue, 17 May 2011 15:31:24 GMT

D'Alise AM et al; Proceedings of the National Academy of Sciences of the United States of America 2011 May 4

Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62L(lo) FoxP3(+) CD4(+) T cells with limited suppressor activity.

Tue, 17 May 2011 15:31:23 GMT

Goudy KS et al; Eur. J. Immunol. 2011 May; 41(5)

CD4(+) T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs.

Mon, 4 Apr 2011 17:01:43 GMT

Sun J et al; Nat. Immunol. 2011 Apr; 12(4)

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.

Mon, 4 Apr 2011 17:01:31 GMT

Mells GF et al; Nature genetics 2011; 43(4)

Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans.

Mon, 4 Apr 2011 17:01:18 GMT

Calderon B et al; Proc. Natl. Acad. Sci. U.S.A. 2011 Jan 25; 108(4)

Genomics: Genomes in three dimensions.

Mon, 4 Apr 2011 17:01:01 GMT

Baker M et al; Nature 2011 Feb 10; 470(7333)

Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans.

Mon, 14 Mar 2011 10:10:50 GMT

Calderon B et al; Proc. Natl. Acad. Sci. U.S.A. 2011 Jan 25; 108(4)

CD4(+) T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs.

Mon, 14 Mar 2011 10:10:16 GMT

Sun J et al; Nature immunology 2011 Feb 6

Diet, gut microbiota and immune responses.

Mon, 14 Mar 2011 10:09:47 GMT

Maslowski KM et al; Nat. Immunol. 2011 Jan; 12(1)

Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells.

Thu, 24 Feb 2011 12:06:08 GMT

Lau-Kilby AW et al; Proc. Natl. Acad. Sci. U.S.A. 2011 Feb 8; 108(6)

Unmasking Genes in a Type 1 Diabetes-Resistant Mouse Strain That Enhances Pathogenic CD8 T-Cell Responses.

Thu, 24 Feb 2011 12:06:07 GMT

Driver JP et al; Diabetes 2011 Feb 9

IL-2 production by dendritic cells promotes Foxp3(+) regulatory T-cell expansion in autoimmune-resistant NOD congenic mice.

Thu, 24 Feb 2011 12:04:58 GMT

Sgouroudis E et al; Autoimmunity 2011 Jan 19

Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells.

Mon, 7 Feb 2011 15:00:45 GMT

Lau-Kilby AW et al; Proceedings of the National Academy of Sciences of the United States of America 2011 Jan 24

An Allele of IKZF1 (Ikaros) Conferring Susceptibility to Childhood Acute Lymphoblastic Leukemia Protects Against Type 1 Diabetes.

Mon, 7 Feb 2011 15:00:33 GMT

Swafford AD et al; Diabetes 2011 Jan 26

Synthetic associations are unlikely to account for many common disease genome-wide association signals.

Mon, 7 Feb 2011 13:58:56 GMT

Anderson CA et al; PLoS Biol. 2011; 9(1)

Synthetic Associations Created by Rare Variants Do Not Explain Most GWAS Results.

Mon, 7 Feb 2011 13:58:53 GMT

Wray NR et al; PLoS Biol. 2011; 9(1)

Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population.

Wed, 5 Jan 2011 12:04:58 GMT

Aminkeng F et al; Hum. Immunol. 2010 Dec; 71(12)

Carriers of rare missense variants in IFIH1 are protected from psoriasis.

Wed, 5 Jan 2011 11:10:29 GMT

Li Y et al; J. Invest. Dermatol. 2010 Dec; 130(12)

Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases.

Wed, 8 Dec 2010 15:54:23 GMT

Buckner JH et al; Nat. Rev. Immunol. 2010 Dec; 10(12)

A recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibility.

Tue, 16 Nov 2010 14:25:13 GMT

Tan IK et al; A recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibility. 2010 Nov 4

Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a β-cell neo-self-antigen in type 1 diabetes prone NOD mice.

Tue, 16 Nov 2010 14:25:13 GMT

Cox SL et al; Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a β-cell neo-self-antigen in type 1 diabetes prone NOD mice. 2010 Sep 21

mt-Nd2a modifies resistance against autoimmune Type 1 diabetes in NOD mice at the level of the pancreatic beta cell.

Tue, 16 Nov 2010 14:25:12 GMT

Chen J et al; mt-Nd2a modifies resistance against autoimmune Type 1 diabetes in NOD mice at the level of the pancreatic beta cell. 2010 Oct 27

Tackling the widespread and critical impact of batch effects in high-throughput data.

Wed, 3 Nov 2010 16:59:58 GMT

Leek JT et al; Nat. Rev. Genet. 2010 Oct; 11(10)

Specific gene expression signature associated with development of autoimmune type-I diabetes using whole-blood microarray analysis.

Wed, 3 Nov 2010 16:59:58 GMT

Reynier F et al; Genes Immun. 2010 Apr; 11(3)

Interleukin-2 receptor signaling: at the interface between tolerance and immunity.

Mon, 18 Oct 2010 17:34:08 GMT

Malek TR et al; Immunity 2010 Aug 27; 33(2)

Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine.

Mon, 18 Oct 2010 17:34:07 GMT

Cadwell K et al; Cell 2010 Jun 25; 141(7)

An Environment-Wide Association study (EWAS) on type 2 diabetes mellitus.

Fri, 11 Jun 2010 17:35:10 GMT

Patel CJ et al; PLoS ONE 2010; 5(5)

The long and winding road to understanding and conquering type 1 diabetes.

Fri, 11 Jun 2010 17:35:10 GMT

Santamaria P et al; Immunity 2010 Apr 23; 32(4)

Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.

Fri, 11 Jun 2010 17:35:09 GMT

Monks A et al; J. Natl. Cancer Inst. 1991 Jun 5; 83(11)

Multiple common variants for celiac disease influencing immune gene expression.

Fri, 11 Jun 2010 17:35:07 GMT

Dubois PC et al; Nat. Genet. 2010 Apr; 42(4)

Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.

Fri, 11 Jun 2010 17:17:03 GMT

Zeller T et al; PLoS ONE 2010; 5(5)

Melanoma differentiation-associated protein-5 (MDA-5) limits early viral replication but is not essential for the induction of type 1 interferons after Coxsackievirus infection.

Tue, 16 Mar 2010 11:07:37 GMT

Huhn MH et al; Virology 2010 Mar 3

Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes.

Tue, 1 Dec 2009 12:07:59 GMT

Wang Z et al; Cell 2009 Sep 4; 138(5)

Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus.

Fri, 27 Nov 2009 16:58:00 GMT

McGuire HM et al; Proc. Natl. Acad. Sci. U.S.A. 2009 Nov 17; 106(46)

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

Thu, 26 Nov 2009 16:39:38 GMT

Raychaudhuri S et al; Nat. Genet. 2009 Dec; 41(12)

An agenda for personalized medicine.

Thu, 26 Nov 2009 11:36:38 GMT

Ng PC et al; Nature 2009 Oct 8; 461(7265)

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.

Tue, 1 Sep 2009 16:17:29 GMT

International Schizophrenia Consortium et al; Nature 2009 Aug 6; 460(7256)

Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse.

Tue, 1 Sep 2009 16:16:09 GMT

Kamanaka M et al; Proc. Natl. Acad. Sci. U.S.A. 2009 Jul 7; 106(27)

Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice.

Tue, 1 Sep 2009 16:15:26 GMT

Hamilton-Williams EE et al; J. Immunol. 2009 Aug 1; 183(3)

From genes to function: the next challenge to understanding multiple sclerosis.

Tue, 16 Jun 2009 15:02:39 GMT

Fugger L et al; Nat. Rev. Immunol. 2009 May 15

Allelic imbalance sequencing reveals that single-nucleotide polymorphisms frequently alter microRNA-directed repression.

Tue, 16 Jun 2009 15:02:12 GMT

Kim J et al; Nat. Biotechnol. 2009 May; 27(5)

Diabetes: A virus-gene collaboration.

Tue, 16 Jun 2009 15:01:29 GMT

von Herrath M et al; Nature 2009 May 28; 459(7246)

Association of RASGRP1 with type 1 diabetes is revealed by combined follow-up of two genome-wide studies.

Tue, 16 Jun 2009 15:01:10 GMT

Qu HQ et al; J. Med. Genet. 2009 May 21

Type 1 diabetes in the BB rat: a polygenic disease.

Mon, 8 Jun 2009 13:42:24 GMT

Wallis RH et al; Diabetes 2009 Apr; 58(4)

Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice.

Mon, 8 Jun 2009 13:40:59 GMT

Filippi CM et al; J. Clin. Invest. 2009 Jun; 119(6)

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

Tue, 12 May 2009 11:28:43 GMT

Barrett JC et al. Nature Genetics 2009 May 10

Validating, augmenting and refining genome-wide association signals.

Fri, 1 May 2009 12:34:24 GMT

Ioannidis JP et al; Nat. Rev. Genet. 2009 May; 10(5)

NOD x 129.H2g7 Backcross Delineates 129S1/SvImJ-Derived Genomic Regions Modulating Type 1 Diabetes (T1D) Development In Mice.

Thu, 30 Apr 2009 10:48:13 GMT

Leiter EH et al; Diabetes 2009 Mar 31

Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice.

Thu, 30 Apr 2009 10:47:59 GMT

Jiang F et al; Int. Immunol. 2009 May; 21(5)

Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice.

Tue, 3 Mar 2009 10:49:23 GMT

Chen YG et al; Diabetes 2008 Dec; 57(12)

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors.

Tue, 3 Mar 2009 10:49:23 GMT

D'Alise AM et al; Proc. Natl. Acad. Sci. U.S.A. 2008 Dec 16; 105(50)

Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice.

Sat, 20 Dec 2008 08:06:15 GMT

Mangada J et al; Diabetes 2008 Nov 4

Slc11a1 Enhances the Autoimmune Diabetogenic T-cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens.

Sat, 20 Dec 2008 08:06:15 GMT

Dai YD et al; Diabetes 2008 Nov 4

Detecting shared pathogenesis from the shared genetics of immune-related diseases.

Sat, 20 Dec 2008 08:00:54 GMT

Zhernakova A et al; Nat. Rev. Genet. 2009 Jan; 10(1)

Cutting Edge: The Idd3 Genetic Interval Determines Regulatory T Cell Function through CD11b+CD11c- APC.

Mon, 24 Nov 2008 14:04:46 GMT

Anderson AC et al; J. Immunol. 2008 Dec 1; 181(11)

Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice.

Mon, 17 Nov 2008 14:38:23 GMT

Sgouroudis E et al; J. Immunol. 2008 Nov 1; 181(9)

Genetic mapping in human disease.

Mon, 17 Nov 2008 14:32:49 GMT

Altshuler D et al; Science 2008 Nov 7; 322(5903)

Integrated detection and population-genetic analysis of SNPs and copy number variation.

Tue, 14 Oct 2008 11:37:55 GMT

McCarroll SA et al; Nat. Genet. 2008 Oct; 40(10)

Through regulation of TCR expression levels, an Idd7 region gene(s) interactively contributes to the impaired thymic deletion of autoreactive diabetogenic CD8+ T cells in nonobese diabetic mice.

Wed, 20 Aug 2008 13:17:21 GMT

Serreze DV et al; J. Immunol. 2008 Mar 1; 180(5)

Differential allelic expression in the human genome: a robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression.

Wed, 20 Aug 2008 13:17:21 GMT

Serre D et al; PLoS Genet. 2008 Feb; 4(2)

Genome-wide association studies for complex traits: consensus, uncertainty and challenges.

Wed, 20 Aug 2008 13:17:21 GMT

McCarthy MI et al; Nat. Rev. Genet. 2008 May; 9(5)

Agouti NOD: identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells.

Wed, 20 Aug 2008 13:17:21 GMT

Chen J et al; Mamm. Genome 2005 Oct; 16(10)

The transcriptional landscape of the yeast genome defined by RNA sequencing.

Wed, 20 Aug 2008 13:17:21 GMT

Nagalakshmi U et al; Science 2008 Jun 6; 320(5881)

Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKT2 cells in nonobese diabetic mice.

Wed, 20 Aug 2008 13:17:21 GMT

Baev DV et al; J. Immunol. 2008 Jul 15; 181(2)

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.

Wed, 20 Aug 2008 13:17:21 GMT

Tang Q et al; Immunity 2008 May; 28(5)

Genome-wide association studies: a new window into immune-mediated diseases.

Wed, 20 Aug 2008 13:17:21 GMT

Xavier RJ et al; Nat. Rev. Immunol. 2008 Aug; 8(8)

Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation.

Wed, 20 Aug 2008 13:17:16 GMT

Kerkel K et al; Nat. Genet. 2008 Jul; 40(7)

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

Wed, 20 Aug 2008 13:17:10 GMT

Barrett JC et al. Nature Genetics 2008 Jun 29

Virus Infection Induces NF-kappaB-dependent interchromosomal associations mediating monoallelic IFN-beta gene expression.

Wed, 20 Aug 2008 13:15:57 GMT

Apostolou E et al; Cell 2008 Jul 11; 134(1)