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3p21.31

General Information: Available

Organism	Human
Points of Interest	rs333; rs11711054
Karyotype Band Location	3p21.31
Chromosomal Location (GRCh37)	Chr3:45980673-46654132
Region Size	0.67 Mb
Orthologous Regions	Mouse: Human 3p21.31 Orthologous Region Mouse: Human 3p21.31 Orthologous Region Rat: Human 3p21.31 Orthologous Region Rat: Human 3p21.31 Orthologous Region
Genes in Region (13)	CCR1, CCR2, CCR3, CCR5, CCRL2, CXCR6, FYCO1, LOC100506485, LRRC2, LTF, RTP3, TDGF1, XCR1

View this region in the Human T1D Regions table.

Non-Synonymous SNPs in region dbSNP134:

Marker	Marker Source	Start	Strand	Peptide Shift	Gene Symbol (HGNC)	Gene ID (Entrez)	Amino Acid Position
rs2234355	dbSNP_134	45987980	+	E/K	CXCR6	10663	3
rs147079093	dbSNP_134	45987999	+	D/A	CXCR6	10663	9
rs144386806	dbSNP_134	45988034	+	E/K	CXCR6	10663	21
rs141408062	dbSNP_134	45988083	+	M/T	CXCR6	10663	37
rs151224196	dbSNP_134	45988293	+	G/D	CXCR6	10663	107
rs149731590	dbSNP_134	45988322	+	M/V	CXCR6	10663	117
rs148910229	dbSNP_134	45988406	+	M/V	CXCR6	10663	145
rs143430697	dbSNP_134	45988407	+	M/K	CXCR6	10663	145
rs145873025	dbSNP_134	45988445	+	I/V	CXCR6	10663	158
rs2234356	dbSNP_134	45988504	+	K/N	CXCR6	10663	177
rs2234357	dbSNP_134	45988689	+	V/A	CXCR6	10663	239
rs113990866	dbSNP_134	45988809	+	L/P	CXCR6	10663	279
rs139181143	dbSNP_134	45988832	+	L/F	CXCR6	10663	287
rs149959485	dbSNP_134	45988848	+	S/I	CXCR6	10663	292
rs141955108	dbSNP_134	45988860	+	R/Q	CXCR6	10663	296
rs143328415	dbSNP_134	45996745	+	E/K	FYCO1	79443	1314
rs140583635	dbSNP_134	45996750	+	A/V	FYCO1	79443	1312
rs142754827	dbSNP_134	45996760	+	D/N	FYCO1	79443	1309
rs145244537	dbSNP_134	45996877	+	T/A	FYCO1	79443	1270
rs144182297	dbSNP_134	45999920	+	P/R	FYCO1	79443	1260
rs140160920	dbSNP_134	45999992	+	S/F	FYCO1	79443	1236
rs141449193	dbSNP_134	46000982	+	L/V	FYCO1	79443	1164
rs41289620	dbSNP_134	46003735	+	R/Q	FYCO1	79443	1140
rs141443199	dbSNP_134	46003736	+	R/W	FYCO1	79443	1140
rs138239824	dbSNP_134	46003742	+	E/K	FYCO1	79443	1138
rs140583835	dbSNP_134	46003762	+	N/T	FYCO1	79443	1131
rs147342222	dbSNP_134	46003796	+	D/H	FYCO1	79443	1120
rs148343002	dbSNP_134	46003807	+	R/H	FYCO1	79443	1116
rs139535132	dbSNP_134	46003831	+	K/R	FYCO1	79443	1108
rs73830668	dbSNP_134	46003832	+	K/E	FYCO1	79443	1108
rs145889343	dbSNP_134	46003856	+	T/A	FYCO1	79443	1100
rs148926018	dbSNP_134	46003862	+	A/T	FYCO1	79443	1098
rs148106976	dbSNP_134	46003868	+	E/K	FYCO1	79443	1096
rs35869281	dbSNP_134	46005853	+	G/G	FYCO1	79443	1081
rs6795530	dbSNP_134	46005863	+	D/E	FYCO1	79443	1078
rs148445016	dbSNP_134	46005882	+	A/V	FYCO1	79443	1072
rs142618914	dbSNP_134	46005885	+	Q/R	FYCO1	79443	1071
rs146592828	dbSNP_134	46007802	+	S/R	FYCO1	79443	1008
rs13079478	dbSNP_134	46007823	+	N/K	FYCO1	79443	1001
rs13059238	dbSNP_134	46007825	+	N/D	FYCO1	79443	1001
rs71622515	dbSNP_134	46007825	-	N/N	FYCO1	79443	1001
rs34801630	dbSNP_134	46007846	+	E/K	FYCO1	79443	994
rs142098311	dbSNP_134	46007860	+	A/V	FYCO1	79443	989
rs139192007	dbSNP_134	46007879	+	A/T	FYCO1	79443	983
rs148054715	dbSNP_134	46007887	+	A/G	FYCO1	79443	980
rs150498691	dbSNP_134	46007969	+	G/W	FYCO1	79443	953
rs138529231	dbSNP_134	46007980	+	R/H	FYCO1	79443	949
rs149818737	dbSNP_134	46008020	+	A/T	FYCO1	79443	936
rs113517878	dbSNP_134	46008214	+	R/Q	FYCO1	79443	871
rs145893350	dbSNP_134	46008274	+	R/H	FYCO1	79443	851
rs143183175	dbSNP_134	46008280	+	S/L	FYCO1	79443	849
rs141689540	dbSNP_134	46008312	+	N/K	FYCO1	79443	838
rs138619849	dbSNP_134	46008428	+	R/W	FYCO1	79443	800
rs35450771	dbSNP_134	46008475	+	E/G	FYCO1	79443	784
rs34266136	dbSNP_134	46008532	+	R/H	FYCO1	79443	765
rs148946276	dbSNP_134	46008536	+	A/T	FYCO1	79443	764
rs36014492	dbSNP_134	46008647	+	H/N	FYCO1	79443	727
rs3796375	dbSNP_134	46008790	+	A/V	FYCO1	79443	679
rs140426191	dbSNP_134	46008791	+	A/T	FYCO1	79443	679
rs141155944	dbSNP_134	46008820	+	S/N	FYCO1	79443	669
rs149472411	dbSNP_134	46008833	+	A/P	FYCO1	79443	665
rs150785981	dbSNP_134	46008841	+	S/F	FYCO1	79443	662
rs147306927	dbSNP_134	46008862	+	A/G	FYCO1	79443	655
rs143332160	dbSNP_134	46008863	+	A/T	FYCO1	79443	655
rs139252192	dbSNP_134	46008871	+	R/Q	FYCO1	79443	652
rs145238648	dbSNP_134	46008893	+	D/N	FYCO1	79443	645
rs143344626	dbSNP_134	46008938	+	G/R	FYCO1	79443	630
rs140700206	dbSNP_134	46008941	+	V/I	FYCO1	79443	629
rs149507450	dbSNP_134	46008983	+	R/W	FYCO1	79443	615
rs150859970	dbSNP_134	46009135	+		FYCO1	79443	564
rs149277150	dbSNP_134	46009151	+	P/S	FYCO1	79443	559
rs78709484	dbSNP_134	46009157	+	A/S	FYCO1	79443	557
rs139253829	dbSNP_134	46009162	+	R/Q	FYCO1	79443	555
rs148594622	dbSNP_134	46009277	+	F/I	FYCO1	79443	517
rs141828619	dbSNP_134	46009289	+	R/W	FYCO1	79443	513
rs146010173	dbSNP_134	46009324	+	K/R	FYCO1	79443	501
rs143704916	dbSNP_134	46009352	+	R/W	FYCO1	79443	492
rs146711260	dbSNP_134	46009387	+	T/M	FYCO1	79443	480
rs33910087	dbSNP_134	46009487	+	R/C	FYCO1	79443	447
rs116404907	dbSNP_134	46009501	+	R/Q	FYCO1	79443	442
rs72889997	dbSNP_134	46009574	+	E/K	FYCO1	79443	418
rs139644945	dbSNP_134	46009663	+	R/Q	FYCO1	79443	388
rs3733101	dbSNP_134	46009684	-	T/M	FYCO1	79443	381
rs139604029	dbSNP_134	46009705	+	M/T	FYCO1	79443	374
rs35937665	dbSNP_134	46009763	+	R/W	FYCO1	79443	355
rs114145679	dbSNP_134	46009810	+	R/Q	FYCO1	79443	339
rs3733100	dbSNP_134	46009864	-	G/A	FYCO1	79443	321
rs146311777	dbSNP_134	46009957	+	R/H	FYCO1	79443	290
rs9875356	dbSNP_134	46009981	+	R/H	FYCO1	79443	282
rs146095470	dbSNP_134	46010012	+	E/K	FYCO1	79443	272
rs3821885	dbSNP_134	46010073	-	E/D	FYCO1	79443	251
rs4683158	dbSNP_134	46010077	+	R/Q	FYCO1	79443	250
rs142017802	dbSNP_134	46010078	+	R/W	FYCO1	79443	250
rs117543659	dbSNP_134	46010113	+	E/A	FYCO1	79443	238
rs143360825	dbSNP_134	46010119	+	R/Q	FYCO1	79443	236
rs140002692	dbSNP_134	46010179	+	S/F	FYCO1	79443	216
rs150218695	dbSNP_134	46010194	+	T/I	FYCO1	79443	211
rs146077270	dbSNP_134	46014641	+	V/L	FYCO1	79443	160
rs142081868	dbSNP_134	46014667	+	V/A	FYCO1	79443	151
rs149818406	dbSNP_134	46014676	+	S/L	FYCO1	79443	148
rs140695972	dbSNP_134	46016774	+	A/T	FYCO1	79443	118
rs145897969	dbSNP_134	46016789	+	V/M	FYCO1	79443	113
rs141476300	dbSNP_134	46021220	+	R/C	FYCO1	79443	89
rs138113982	dbSNP_134	46021292	+	G/R	FYCO1	79443	65
rs144455195	dbSNP_134	46023148	+	K/E	FYCO1	79443	26
rs148420941	dbSNP_134	46026359	+	R/Q	FYCO1	79443	15
rs144444715	dbSNP_134	46062573	+	F/L	XCR1	2829	289
rs149762656	dbSNP_134	46062611	+	F/V	XCR1	2829	277
rs143288594	dbSNP_134	46062622	+	R/H	XCR1	2829	273
rs138429796	dbSNP_134	46062676	+	I/S	XCR1	2829	255
rs78405233	dbSNP_134	46062922	+	S/L	XCR1	2829	173
rs139879820	dbSNP_134	46062953	+	L/F	XCR1	2829	163
rs144371089	dbSNP_134	46063003	+	R/Q	XCR1	2829	146
rs151337542	dbSNP_134	46063061	+	R/C	XCR1	2829	127
rs145379918	dbSNP_134	46063091	+	I/F	XCR1	2829	117
rs142460103	dbSNP_134	46063154	+	V/M	XCR1	2829	96
rs148890920	dbSNP_134	46063165	+	H/R	XCR1	2829	92
rs138563781	dbSNP_134	46063277	+	V/I	XCR1	2829	55
rs150654881	dbSNP_134	46063301	+	V/M	XCR1	2829	47
rs140218706	dbSNP_134	46063343	+	A/T	XCR1	2829	33
rs61755290	dbSNP_134	46244786	+	S/I	CCR1	1230	340
rs112927319	dbSNP_134	46244849	+	R/H	CCR1	1230	319
rs41393844	dbSNP_134	46244934	-	Y/H	CCR1	1230	291
rs143491674	dbSNP_134	46244937	+	A/T	CCR1	1230	290
rs80151884	dbSNP_134	46245210	+	Q/X	CCR1	1230	199
rs61752589	dbSNP_134	46245329	+	A/V	CCR1	1230	159
rs140711017	dbSNP_134	46245422	+	T/M	CCR1	1230	128
rs144879031	dbSNP_134	46245480	+	L/V	CCR1	1230	109
rs150303999	dbSNP_134	46245524	+	K/R	CCR1	1230	94
rs138822282	dbSNP_134	46245525	+	K/Q	CCR1	1230	94
rs76628634	dbSNP_134	46245596	+	S/N	CCR1	1230	70
rs142817888	dbSNP_134	46245624	+	Q/K	CCR1	1230	61
rs150010238	dbSNP_134	46245713	+	A/D	CCR1	1230	31
rs6781048	dbSNP_134	46245777	+	Y/D	CCR1	1230	10
rs4987124	dbSNP_134	46306642	+	R/K	CCR3	1232	19
rs142492736	dbSNP_134	46306687	+	T/I	CCR3	1232	34
rs145868328	dbSNP_134	46306707	+	V/M	CCR3	1232	41
rs4987125	dbSNP_134	46306711	+	G/D	CCR3	1232	42
rs5742906	dbSNP_134	46306765	+	P/L	CCR3	1232	60
rs144652077	dbSNP_134	46306836	+	R/G	CCR3	1232	84
rs141859798	dbSNP_134	46306881	+	I/F	CCR3	1232	99
rs35272086	dbSNP_134	46306994	+	T/T	CCR3	1232	136
rs145141172	dbSNP_134	46307064	+	V/M	CCR3	1232	160
rs56177184	dbSNP_134	46307077	+	R/Q	CCR3	1232	164
rs61738836	dbSNP_134	46307089	+	V/A	CCR3	1232	168
rs141252964	dbSNP_134	46307107	+	T/I	CCR3	1232	174
rs56114788	dbSNP_134	46307115	+	V/I	CCR3	1232	177
rs41276533	dbSNP_134	46307134	+	V/G	CCR3	1232	183
rs146703988	dbSNP_134	46307274	+	V/I	CCR3	1232	230
rs62243923	dbSNP_134	46307277	+	L/V	CCR3	1232	231
rs140574649	dbSNP_134	46307286	+	L/F	CCR3	1232	234
rs138346219	dbSNP_134	46307313	+	I/V	CCR3	1232	243
rs142051640	dbSNP_134	46307365	+	R/Q	CCR3	1232	260
rs142318962	dbSNP_134	46307377	+	V/A	CCR3	1232	264
rs148454821	dbSNP_134	46307391	+	F/V	CCR3	1232	269
rs41515745	dbSNP_134	46307449	+	I/N	CCR3	1232	288
rs41276535	dbSNP_134	46307472	+	R/W	CCR3	1232	296
rs41409552	dbSNP_134	46307473	+	R/Q	CCR3	1232	296
rs139319342	dbSNP_134	46307553	+	A/T	CCR3	1232	323
rs144967964	dbSNP_134	46307586	+	R/S	CCR3	1232	334
rs143778920	dbSNP_134	46307629	+	Y/S	CCR3	1232	348
rs151108824	dbSNP_134	46307682	+	S/P	CCR3	1232	366
rs111826278	dbSNP_134	46307695	+	P/L	CCR3	1232	370
rs147670448	dbSNP_134	46307701	+	L/P	CCR3	1232	372
rs144064659	dbSNP_134	46307709	+	V/L	CCR3	1232	375
rs75236779	dbSNP_134	46399067	+	G/S	CCR2	729230	17
rs4987052	dbSNP_134	46399151	+	L/V	CCR2	729230	45
rs1799864	dbSNP_134	46399208	+	V/I	CCR2	729230	64
rs34948438	dbSNP_134	46399229	+		CCR2	729230	71
rs113340633	dbSNP_134	46399374	-	L/P	CCR2	729230	119
rs140816549	dbSNP_134	46401174	+	F/L	CCR2	729230	316
rs3918387	dbSNP_134	46401290	+	G/E	CCR2	729230	355
rs142904831	dbSNP_134	46414445	+	E/K	CCR5	1234	18
rs145061115	dbSNP_134	46414451	+	C/S	CCR5	1234	20
rs1800939	dbSNP_134	46414478	+	A/S	CCR5	1234	29
rs56340326	dbSNP_134	46414485	+	R/H	CCR5	1234	31
rs41425744	dbSNP_134	46414529	+	V/M	CCR5	1234	46
rs1799863	dbSNP_134	46414557	+	L/Q	CCR5	1234	55
rs1800940	dbSNP_134	46414573	+	R/S	CCR5	1234	60
rs142829420	dbSNP_134	46414580	+	S/C	CCR5	1234	63
rs138220300	dbSNP_134	46414595	+	Y/H	CCR5	1234	68
rs56198941	dbSNP_134	46414611	+	A/V	CCR5	1234	73
rs149975182	dbSNP_134	46414676	+	D/N	CCR5	1234	95
rs1800560	dbSNP_134	46414696	+	C/X	CCR5	1234	101
rs138174483	dbSNP_134	46414712	+	L/F	CCR5	1234	107
rs150497029	dbSNP_134	46414755	+	L/R	CCR5	1234	121
rs146209111	dbSNP_134	46414766	+	D/N	CCR5	1234	125
rs34418657	dbSNP_134	46414784	+	V/F	CCR5	1234	131
rs333	dbSNP_134	46414947	+		CCR5	1234	185
rs112590754	dbSNP_134	46414947	+	S/I	CCR5	1234	185
rs111718604	dbSNP_134	46414948	+	S/R	CCR5	1234	185
rs113869679	dbSNP_134	46414949	+	Q/K	CCR5	1234	186
rs56345960	dbSNP_134	46414972	+	F/L	CCR5	1234	193
rs62625034	dbSNP_134	46414975	-	Q/H	CCR5	1234	194
rs113552054	dbSNP_134	46415010	+	P/L	CCR5	1234	206
rs151126808	dbSNP_134	46415052	+	T/I	CCR5	1234	220
rs1800452	dbSNP_134	46415061	+	R/Q	CCR5	1234	223
rs146972949	dbSNP_134	46415066	+	R/X	CCR5	1234	225
rs147615392	dbSNP_134	46415098	+	R/S	CCR5	1234	235
rs143181119	dbSNP_134	46415130	+	L/P	CCR5	1234	246
rs142469507	dbSNP_134	46415163	+	L/Q	CCR5	1234	257
rs112762802	dbSNP_134	46415217	+	L/W	CCR5	1234	275
rs139358456	dbSNP_134	46415235	+	V/A	CCR5	1234	281
rs55956105	dbSNP_134	46415253	+	M/R	CCR5	1234	287
rs150592242	dbSNP_134	46415255	+	T/A	CCR5	1234	288
rs149622978	dbSNP_134	46415260	+	H/Q	CCR5	1234	289
rs55916127	dbSNP_134	46415294	+	G/R	CCR5	1234	301
rs1800943	dbSNP_134	46415295	+	G/V	CCR5	1234	301
rs34962689	dbSNP_134	46415381	+	E/R	CCR5	1234	330
rs147879075	dbSNP_134	46415393	+	R/X	CCR5	1234	334
rs1800944	dbSNP_134	46415397	+	A/V	CCR5	1234	335
rs1800945	dbSNP_134	46415409	+	Y/F	CCR5	1234	339
rs11574443	dbSNP_134	46449581	+	Y/C	CCRL2	9034	4
rs143567349	dbSNP_134	46449637	+	D/N	CCRL2	9034	23
rs139536016	dbSNP_134	46449718	+	V/L	CCRL2	9034	50
rs142950457	dbSNP_134	46449751	+	L/F	CCRL2	9034	61
rs111863112	dbSNP_134	46449863	+	G/E	CCRL2	9034	98
rs140688623	dbSNP_134	46450042	+		CCRL2	9034	158
rs3204849	dbSNP_134	46450070	+	F/Y	CCRL2	9034	167
rs6441977	dbSNP_134	46450072	+	V/M	CCRL2	9034	168
rs56127823	dbSNP_134	46450229	+	Y/C	CCRL2	9034	220
rs3204850	dbSNP_134	46450297	+	I/V	CCRL2	9034	243
rs145501356	dbSNP_134	46450429	+	L/I	CCRL2	9034	287
rs141265011	dbSNP_134	46450472	+	A/V	CCRL2	9034	301
rs148907755	dbSNP_134	46477697	+	L/F	LTF	4057	664
rs137886255	dbSNP_134	46479431	+	P/S	LTF	4057	656
rs144655734	dbSNP_134	46479532	+	T/I	LTF	4057	622
rs148227142	dbSNP_134	46479551	+	L/F	LTF	4057	616
rs150670421	dbSNP_134	46479574	+	L/X	LTF	4057	608
rs66977363	dbSNP_134	46479578	+	F/F	LTF	4057	606
rs9110	dbSNP_134	46480801	-	L/M	LTF	4057	588
rs145382222	dbSNP_134	46480815	+	R/H	LTF	4057	583
rs142148325	dbSNP_134	46480833	+	R/Q	LTF	4057	577
rs144149027	dbSNP_134	46480854	+	P/L	LTF	4057	570
rs139367879	dbSNP_134	46480909	+	D/N	LTF	4057	552
rs149901533	dbSNP_134	46480950	+	A/V	LTF	4057	538
rs2073495	dbSNP_134	46480958	+	E/D	LTF	4057	535
rs143317180	dbSNP_134	46484932	+	R/L	LTF	4057	508
rs143486027	dbSNP_134	46484951	+	G/S	LTF	4057	502
rs143806293	dbSNP_134	46484967	+	S/R	LTF	4057	496
rs17851345	dbSNP_134	46484977	+	V/E	LTF	4057	493
rs139737053	dbSNP_134	46484978	+	V/M	LTF	4057	493
rs66892674	dbSNP_134	46484989	+	E/G	LTF	4057	489
rs67186015	dbSNP_134	46484995	+	Q/A	LTF	4057	487
rs144111141	dbSNP_134	46485023	+	L/F	LTF	4057	478
rs141127151	dbSNP_134	46485035	+	P/S	LTF	4057	474
rs150320764	dbSNP_134	46486793	+	Q/E	LTF	4057	454
rs147094293	dbSNP_134	46486841	+	V/L	LTF	4057	438
rs144107611	dbSNP_134	46486879	+	W/L	LTF	4057	425
rs142639136	dbSNP_134	46486891	+	T/N	LTF	4057	421
rs1803892	dbSNP_134	46486897	-	S/X	LTF	4057	419
rs17855463	dbSNP_134	46486919	+	A/T	LTF	4057	412
rs61739313	dbSNP_134	46487937	+	V/M	LTF	4057	407
rs146002167	dbSNP_134	46487942	+	R/K	LTF	4057	405
rs148398608	dbSNP_134	46488832	+	C/R	LTF	4057	380
rs1042055	dbSNP_134	46488838	-	G/C	LTF	4057	378
rs142586198	dbSNP_134	46490406	+	S/N	LTF	4057	343
rs112765886	dbSNP_134	46490473	+	V/M	LTF	4057	321
rs144305401	dbSNP_134	46490488	+	R/W	LTF	4057	316
rs144721345	dbSNP_134	46490497	+	V/L	LTF	4057	313
rs151316517	dbSNP_134	46491412	+	P/L	LTF	4057	286
rs145613102	dbSNP_134	46491413	+	P/A	LTF	4057	286
rs138890561	dbSNP_134	46491429	+	I/M	LTF	4057	280
rs138966671	dbSNP_134	46491431	+	I/F	LTF	4057	280
rs72153807	dbSNP_134	46491489	+	K/K	LTF	4057	260
rs148283280	dbSNP_134	46491995	+	R/H	LTF	4057	247
rs144240700	dbSNP_134	46492103	+	R/Q	LTF	4057	211
rs74762169	dbSNP_134	46492149	+	E/K	LTF	4057	196
rs145813972	dbSNP_134	46495807	+	S/G	LTF	4057	187
rs139895902	dbSNP_134	46496813	+	P/S	LTF	4057	163
rs60938611	dbSNP_134	46496854	+	A/V	LTF	4057	149
rs141442902	dbSNP_134	46497295	+	I/L	LTF	4057	120
rs148941436	dbSNP_134	46497312	+	T/M	LTF	4057	114
rs34538438	dbSNP_134	46497326	+	P/P	LTF	4057	109
rs148123129	dbSNP_134	46497330	+	R/H	LTF	4057	108
rs146006710	dbSNP_134	46497331	+	R/C	LTF	4057	108
rs1126479	dbSNP_134	46497342	-	I/T	LTF	4057	104
rs150810057	dbSNP_134	46497361	+	A/T	LTF	4057	98
rs142920270	dbSNP_134	46497369	+	R/H	LTF	4057	95
rs17851991	dbSNP_134	46497372	+	L/R	LTF	4057	94
rs17851346	dbSNP_134	46497397	+	G/C	LTF	4057	86
rs143898414	dbSNP_134	46497432	+	K/R	LTF	4057	74
rs149459794	dbSNP_134	46497438	+	V/G	LTF	4057	72
rs139246528	dbSNP_134	46497791	+	G/E	LTF	4057	58
rs141374231	dbSNP_134	46497815	+	R/Q	LTF	4057	50
rs141854619	dbSNP_134	46501168	+	I/N	LTF	4057	18
rs138560816	dbSNP_134	46501172	+	P/S	LTF	4057	17
rs17855496	dbSNP_134	46501205	+	G/R	LTF	4057	6
rs1126478	dbSNP_134	46501213	-	K/R	LTF	4057	3
rs145332035	dbSNP_134	46541873	+	N/K	RTP3	83597	61
rs116177254	dbSNP_134	46542052	+	R/Q	RTP3	83597	121
rs150882797	dbSNP_134	46542085	+	Q/R	RTP3	83597	132
rs147336042	dbSNP_134	46542109	+	I/N	RTP3	83597	140
rs147475691	dbSNP_134	46542286	+	Y/C	RTP3	83597	199
rs150984599	dbSNP_134	46542334	+	C/S	RTP3	83597	215
rs115227529	dbSNP_134	46542370	+	V/A	RTP3	83597	227
rs148260840	dbSNP_134	46563013	+	R/S	LRRC2	79442	355
rs34529469	dbSNP_134	46563026	+	D/R	LRRC2	79442	351
rs141371381	dbSNP_134	46563069	+	R/C	LRRC2	79442	337
rs146766759	dbSNP_134	46563074	+	R/L	LRRC2	79442	335
rs150762901	dbSNP_134	46563125	+	P/L	LRRC2	79442	318
rs139370733	dbSNP_134	46571402	+	I/V	LRRC2	79442	256
rs142961281	dbSNP_134	46571410	+	P/L	LRRC2	79442	253
rs148660546	dbSNP_134	46571464	+	R/P	LRRC2	79442	235
rs143409476	dbSNP_134	46571465	+	R/W	LRRC2	79442	235
rs140423493	dbSNP_134	46574282	+	L/S	LRRC2	79442	203
rs113859270	dbSNP_134	46574325	+	C/R	LRRC2	79442	189
rs115132856	dbSNP_134	46574357	+	Y/S	LRRC2	79442	178
rs150109562	dbSNP_134	46580563	+	N/K	LRRC2	79442	154
rs17078944	dbSNP_134	46580591	+	A/E	LRRC2	79442	145
rs144512849	dbSNP_134	46580652	+	E/Q	LRRC2	79442	125
rs34850909	dbSNP_134	46580676	+	L/M	LRRC2	79442	117
rs17286758	dbSNP_134	46586622	+	T/A	LRRC2	79442	83
rs146246618	dbSNP_134	46586648	+	R/Q	LRRC2	79442	74
rs150599289	dbSNP_134	46586682	+	Y/H	LRRC2	79442	63
rs145124806	dbSNP_134	46586685	+	V/I	LRRC2	79442	62
rs142071651	dbSNP_134	46592967	+	A/T	LRRC2	79442	39
rs28687398	dbSNP_134	46592987	+	V/A	LRRC2	79442	32
rs143768101	dbSNP_134	46593054	+	I/L	LRRC2	79442	10
rs34996741	dbSNP_134	46593062	+	V/A	LRRC2	79442	7
rs149392274	dbSNP_134	46620604	+	I/F	TDGF1	6997	19
rs11130097	dbSNP_134	46620614	+	V/A	TDGF1	6997	22
rs2293025	dbSNP_134	46620760	-	Y/D	TDGF1	6997	43
rs138710229	dbSNP_134	46620818	+	R/Q	TDGF1	6997	62
rs145684302	dbSNP_134	46620827	+	Q/R	TDGF1	6997	65
rs148262628	dbSNP_134	46620830	+	R/H	TDGF1	6997	66
rs150810604	dbSNP_134	46621298	+	P/H	TDGF1	6997	98
rs148619685	dbSNP_134	46621330	+	D/H	TDGF1	6997	109
rs34501971	dbSNP_134	46621336	+	R/G	TDGF1	6997	111
rs121909501	dbSNP_134	46621476	+	P/L	TDGF1	6997	125
rs146889320	dbSNP_134	46621518	+	R/H	TDGF1	6997	139
rs138586687	dbSNP_134	46622648	+	V/M	TDGF1	6997	159
rs144592797	dbSNP_134	46622664	+	P/R	TDGF1	6997	164
rs143388946	dbSNP_134	46622685	+	R/H	TDGF1	6997	171
rs140356933	dbSNP_134	46622690	+	T/A	TDGF1	6997	173

(Human) GRCh37 - chr3:45980673..46654132 (673.46 kb)  View in Genome Browser

An overview of the region is provided by GBrowse. Tracks shown include gene information and study-specific data:
Immune Disease Associated Variants	Variants shown to be associated with different auto-immune diseases
P-values, -log(p)	1 degree of freedom p-values, stratified by geographic location. Generated using snpMatrix with data from the T1DGC Meta-analysis study.
HapMap Recobination Data	Genome-wide recombination rate from Phase 2 HapMap estimated from phased haplotypes in HapMap Release 22 (NCBI 36). Units are in cM/Mb, coordinates have been projected to the current build.

Genes in LD Region: Available

Summary data derived from GWA meta analysis Barrett et al. LD regions were calculated using different r² and D' threshold values, and these regions were then examined for genes. The definition of a gene location includes a 3kb flanking region either side of the gene.

Marker Data		Region Data					Links
		r2 Threshold	D' Threshold	Region	Genes
Marker rs11711054 Chr 3 Position 46345611 Strand P-Value 1.69e-05		N/A	0.5	chr3: 46263244..46543325	CCR3 CCR5 LTF CCR2 RTP3 CCRL2		LD Region Feature File LD File
		0.4	N/A	chr3: 46272456..46404163	CCR3 CCR2
		0.8	N/A	chr3: 46278670..46402627	CCR3 CCR2
		1	N/A	chr3: 46343534..46401032	CCR2

Publications: 2

• Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
  Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS, The Type 1 Diabetes Genetics Consortium
  Nat Genet. 2009
  PubMed ID: 19430480
   
  
• Shared and distinct genetic variants in type 1 diabetes and celiac disease.
  Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA, Todd JA
  N Engl J Med. 2008
  PubMed ID: 19073967
   
  

Signal Clouds: Available

Genotype data for collections is plotted to give a visual sense of the quality of clustering. The two homozygous and the heterozygous genotypes are represented by different colours; a clear separation between the clouds is indicative of good clustering.

Source: ImmunoChip

Source: T1DGC 4K-4K Study - 2008

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