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6q27

General Information: Available

Organism	Human
Points of Interest	rs924043
Karyotype Band Location	6q27
Chromosomal Location (GRCh37)	Chr6:170279658-170446778
Region Size	0.17 Mb
Orthologous Regions	Mouse: Human 6q27 Orthologous Region Rat: Human 6q27 Orthologous Region
Genes in Region (0)

View this region in the Human T1D Regions table.

(Human) GRCh37 - chr6:170279658..170446778 (167.12 kb)  View in Genome Browser

An overview of the region is provided by GBrowse. Tracks shown include gene information and study-specific data:
Immune Disease Associated Variants	Variants shown to be associated with different auto-immune diseases
P-values, -log(p)	1 degree of freedom p-values, stratified by geographic location. Generated using snpMatrix with data from the T1DGC Meta-analysis study.
HapMap Recobination Data	Genome-wide recombination rate from Phase 2 HapMap estimated from phased haplotypes in HapMap Release 22 (NCBI 36). Units are in cM/Mb, coordinates have been projected to the current build.

Non-Synonymous SNPs in region dbSNP135:

returned no results for this query.

Genes in LD Region: Available

LD regions were calculated using different r² and D' threshold values, and these regions were then examined for genes. The definition of a gene location includes a 3kb flanking region either side of the gene.

Marker Data		Region Data					Links
		r2 Threshold	D' Threshold	Region	Genes
Marker rs924043 Chr 6 Position 170379025 Strand		N/A	0.5	chr6: 170357336..170427206			LD Region Feature File LD File
		0.4	N/A	chr6: 170357336..170408134
		0.8	N/A	chr6: 170377812..170390602
		1	N/A	chr6: 170377812..170379025

Signal Clouds: Available

Genotype data for collections is plotted to give a visual sense of the quality of clustering. The two homozygous and the heterozygous genotypes are represented by different colours; a clear separation between the clouds is indicative of good clustering.

Source: T1DGC 4K-4K Study - 2008

Publications: 1

• A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
  Bradfield JP, Qu HQ, Wang K, Zhang H, Sleiman PM, Kim CE, Mentch FD, Qiu H, Glessner JT, Thomas KA, Frackelton EC, Chiavacci RM, Imielinski M, Monos DS, Pandey R, Bakay M, Grant SF, Polychronakos C, Hakonarson H
  PLoS Genet. 2011
  PubMed ID: 21980299
   
  

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Printed on Thu May 24, 2012