T1DBase - A Bioinformatics Resource for Type 1 Diabetes Researchers

General Information: Available

Organism	Mouse
Points of Interest	Il2, IL21
Karyotype Band Location	3qB
Chromosomal Location (NCBIM37)	Chr3:36626676-37277405
Region Size	0.65 Mb
Genes in Region (8)	4932438A13Rik, Adad1, Bbs12, Cetn4, Fgf2, Gm12541, Il2, Il21

(Mouse) NCBIM37 - chr3:36626676..37277405 (650.73 kb) View in Genome Browser

Regions Overlapping this Feature: Mouse: 1

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 4q27 Orthologous Region	Mouse	chr3:36628818..37183472	0.55	4

Publications: 19

Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice.
Matsuki N, Stanic AK, Embers ME, Van Kaer L, Morel L, Joyce S
J Immunol. 2003
PubMed ID: 12759418
Genetic analysis of autoimmune sialadenitis in nonobese diabetic mice: a major susceptibility region on chromosome 1.
Boulard O, Fluteau G, Eloy L, Damotte D, Bedossa P, Garchon HJ
J Immunol. 2002
PubMed ID: 11937580
NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.
Hill NJ, Lyons PA, Armitage N, Todd JA, Wicker LS, Peterson LB
Diabetes. 2000
PubMed ID: 11016460
Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjögren's syndrome-like autoimmune exocrinopathy.
Brayer J, Lowry J, Cha S, Robinson CP, Yamachika S, Peck AB, Humphreys-Beher MG
J Rheumatol. 2000
PubMed ID: 10955330
Restriction landmark genomic scanning of mouse liver tumors for gene amplification: overexpression of cyclin A2.
Haddad R, Morrow AD, Plass C, Held WA
Biochem Biophys Res Commun. 2000
PubMed ID: 10903917
QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2.
Encinas JA, Wicker LS, Peterson LB, Mukasa A, Teuscher C, Sobel R, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK
Nat Genet. 1999
PubMed ID: 9988264
Genetics of autoimmune diabetes in animal models.
McDuffie M
Curr Opin Immunol. 1998
PubMed ID: 9914220
Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.
Podolin PL, Denny P, Lord CJ, Hill NJ, Todd JA, Peterson LB, Wicker LS, Lyons PA
J Immunol. 1997
PubMed ID: 9257847
Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene.
Denny P, Lord CJ, Hill NJ, Goy JV, Levy ER, Podolin PL, Peterson LB, Wicker LS, Todd JA, Lyons PA
Diabetes. 1997
PubMed ID: 9075813
Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits.
Yui MA, Muralidharan K, Moreno-Altamirano B, Perrin G, Chestnut K, Wakeland EK
Mamm Genome. 1996
PubMed ID: 8661724
Aod2, the locus controlling development of atrophy in neonatal thymectomy-induced autoimmune ovarian dysgenesis, co-localizes with Il2, Fgfb, and Idd3.
Teuscher C, Wardell BB, Lunceford JK, Michael SD, Tung KS
J Exp Med. 1996
PubMed ID: 8627174
Crosses of NOD mice with the related NON strain. A polygenic model for IDDM.
McAleer MA, Reifsnyder P, Palmer SM, Prochazka M, Love JM, Copeman JB, Powell EE, Rodrigues NR, Prins JB, Serreze DV
Diabetes. 1995
PubMed ID: 7556956
Mapping the diabetes polygene Idd3 on mouse chromosome 3 by use of novel congenic strains.
Lord CJ, Bohlander SK, Hopes EA, Montague CT, Hill NJ, Prins JB, Renjilian RJ, Peterson LB, Wicker LS, Todd JA
Mamm Genome. 1995
PubMed ID: 8535060
Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes.
Wicker LS, Todd JA, Prins JB, Podolin PL, Renjilian RJ, Peterson LB
J Exp Med. 1994
PubMed ID: 7964456
Polygenic control of autoimmune diabetes in nonobese diabetic mice.
Ghosh S, Palmer SM, Rodrigues NR, Cordell HJ, Hearne CM, Cornall RJ, Prins JB, McShane P, Lathrop GM, Peterson LB
Nat Genet. 1993
PubMed ID: 8401590
Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice.
Prins JB, Todd JA, Rodrigues NR, Ghosh S, Hogarth PM, Wicker LS, Gaffney E, Podolin PL, Fischer PA, Sirotina A
Science. 1993
PubMed ID: 8480181
Genetics of a multifactorial disease: autoimmune type 1 diabetes mellitus.
Cornall RJ
Clin Sci (Lond). 1993
PubMed ID: 8384947
Genetic analysis of autoimmune type 1 diabetes mellitus in mice.
Todd JA, Aitman TJ, Cornall RJ, Ghosh S, Hall JR, Hearne CM, Knight AM, Love JM, McAleer MA, Prins JB
Nature. 1991
PubMed ID: 1675432
Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice.
Prochazka M, Leiter EH, Serreze DV, Coleman DL
Science. 1987
PubMed ID: 2885918

Idd3