CDC42

Summary Top Help

Gene Description:

cell division cycle 42 homolog (S. cerevisiae); cell division cycle 42 (GTP binding protein, 25kDa); cell division cycle 42 (GTP binding protein)

Synonyms:

CDC42Hs, AU018915, G25K, CDC42, AI747189, Cdc42

Orthologs:

Human CDC42 (protein-coding), Mouse Cdc42 (protein-coding), Rat Cdc42 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr1:22379120..22419437 (40.32 kb) View in Genome Browser

(Mouse) NCBIM37 - chr4:136875611..136913652 (384 kb) View in Genome Browser

(Rat) RGSC3.4 - chr5:156106123..156143040 (36.92 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CDC42:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CDC42:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 21

Biocarta: 6

Reactome: 25

NCI-Nature Pathway Interaction Database: 25

Gene Ontology: 70

Golgi membrane	GO:0000139
Nucleotide binding	GO:0000166
Keratinocyte development	GO:0003334
GTPase activity	GO:0003924
Protein binding	GO:0005515
GTP binding	GO:0005525
Intracellular	GO:0005622
Cytoplasm	GO:0005737
Microtubule organizing center	GO:0005815
Cytosol	GO:0005829
Cytoskeleton	GO:0005856
Plasma membrane	GO:0005886
GTP catabolic process	GO:0006184
Regulation of mitosis	GO:0007088
Nuclear migration	GO:0007097
Establishment or maintenance of cell polarity	GO:0007163
Epidermal growth factor receptor signaling pathway	GO:0007173
Small GTPase mediated signal transduction	GO:0007264
Nervous system development	GO:0007399
Axon guidance	GO:0007411
Blood coagulation	GO:0007596
Positive regulation of gene expression	GO:0010628
Negative regulation of gene expression	GO:0010629
Actin cytoskeleton organization	GO:0030036
Secretory granule	GO:0030141
Filopodium	GO:0030175
Macrophage differentiation	GO:0030225
Midbody	GO:0030496
GTP-dependent protein binding	GO:0030742
Hair follicle morphogenesis	GO:0031069
Positive regulation of pseudopodium assembly	GO:0031274
T cell costimulation	GO:0031295
Negative regulation of protein complex assembly	GO:0031333
Keratinization	GO:0031424
Mitogen-activated protein kinase kinase kinase binding	GO:0031435
Regulation of protein stability	GO:0031647
Thioesterase binding	GO:0031996
Positive regulation of peptidyl-serine phosphorylation	GO:0033138
Adherens junction organization	GO:0034332
Cellular protein localization	GO:0034613
Establishment or maintenance of apical/basal cell polarity	GO:0035088
Multicellular organism growth	GO:0035264
Negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059
Regulation of protein catabolic process	GO:0042176
Muscle cell differentiation	GO:0042692
Cell projection	GO:0042995
Positive regulation of MAPK cascade	GO:0043410
Regulation of protein heterodimerization activity	GO:0043497
Positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552
Apical part of cell	GO:0045177
Positive regulation of DNA replication	GO:0045740
Regulation of protein kinase activity	GO:0045859
Positive regulation of JNK cascade	GO:0046330
Filopodium assembly	GO:0046847
Neuron fate determination	GO:0048664
Actin filament bundle assembly	GO:0051017
Regulation of small GTPase mediated signal transduction	GO:0051056
Positive regulation of muscle cell differentiation	GO:0051149
Spindle midzone	GO:0051233
Cell division	GO:0051301
Regulation of filopodium assembly	GO:0051489
Nucleus localization	GO:0051647
Regulation of attachment of spindle microtubules to kinetochore	GO:0051988
Canonical Wnt receptor signaling pathway	GO:0060070
Epithelial-mesenchymal cell signaling	GO:0060684
Hair follicle placode formation	GO:0060789
Positive regulation of hair follicle cell proliferation	GO:0071338
Positive regulation of cell cycle cytokinesis	GO:0071777
Mitotic spindle	GO:0072686
Epithelial cell-cell adhesion	GO:0090136

Publications from PubMed Top Help

Type 1 Diabetes Publications: 10

Cool-1/{beta}PIX Functions as a Guanine Nucleotide Exchange Factor (GEF) in the Cycling of Cdc42 to Regulate Insulin Secretion.
Kepner EM, Yoder SM, Oh E, Kalwat MA, Wang Z, Quilliam LA, Thurmond DC
Am J Physiol Endocrinol Metab. 2011
PubMed ID: 21828338
Differential phosphorylation of RhoGDI mediates the distinct cycling of Cdc42 and Rac1 to regulate second-phase insulin secretion.
Wang Z, Thurmond DC
J Biol Chem. 2009
PubMed ID: 20028975
Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins.
Wang Z, Thurmond DC
J Cell Sci. 2009
PubMed ID: 19295123
A dual role for IQGAP1 in regulating exocytosis.
Rittmeyer EN, Daniel S, Hsu SC, Osman MA
J Cell Sci. 2008
PubMed ID: 18216334
Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion.
Wang Z, Oh E, Thurmond DC
J Biol Chem. 2007
PubMed ID: 17289663
Caveolin-1 functions as a novel Cdc42 guanine nucleotide dissociation inhibitor in pancreatic beta-cells.
Nevins AK, Thurmond DC
J Biol Chem. 2006
PubMed ID: 16714282
A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis.
Nevins AK, Thurmond DC
J Biol Chem. 2005
PubMed ID: 15537656
Glucose regulates the cortical actin network through modulation of Cdc42 cycling to stimulate insulin secretion.
Nevins AK, Thurmond DC
Am J Physiol Cell Physiol. 2003
PubMed ID: 12760905
Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat.
Plum L, Giesen K, Kluge R, Junger E, Linnartz K, Schürmann A, Becker W, Joost HG
Diabetologia. 2002
PubMed ID: 12107726
Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion.
Kowluru A, Seavey SE, Li G, Sorenson RL, Weinhaus AJ, Nesher R, Rabaglia ME, Vadakekalam J, Metz SA
J Clin Invest. 1996
PubMed ID: 8755667

Publications: 584

Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis.
Aflaki E, Balenga NA, Luschnig-Schratl P, Wolinski H, Povoden S, Chandak PG, Bogner-Strauss JG, Eder S, Konya V, Kohlwein SD, Heinemann A, Kratky D
Cell Mol Life Sci. 2011
PubMed ID: 21533980
HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation.
Nikolic DS, Lehmann M, Felts R, Garcia E, Blanchet FP, Subramaniam S, Piguet V
Blood. 2011
PubMed ID: 21562048
PTEN regulates colorectal epithelial apoptosis through Cdc42 signalling.
Deevi R, Fatehullah A, Jagan I, Nagaraju M, Bingham V, Campbell FC
Br J Cancer. 2011
PubMed ID: 21952626
Cdc42 regulates extracellular matrix remodeling in three dimensions.
Sipes NS, Feng Y, Guo F, Lee HO, Chou FS, Cheng J, Mulloy J, Zheng Y
J Biol Chem. 2011
PubMed ID: 21880728
The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner.
Xie C, Li N, Chen ZJ, Li BL, Song BL
J Biol Chem. 2011
PubMed ID: 21844200
Proper regulation of Cdc42 activity is required for tight actin concentration at the equator during cytokinesis in adherent mammalian cells.
Zhu X, Wang J, Moriguchi K, Liow LT, Ahmed S, Kaverina I, Murata-Hori M
Exp Cell Res. 2011
PubMed ID: 21763307
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
The atypical Guanine-nucleotide exchange factor, dock7, negatively regulates schwann cell differentiation and myelination.
Yamauchi J, Miyamoto Y, Hamasaki H, Sanbe A, Kusakawa S, Nakamura A, Tsumura H, Maeda M, Nemoto N, Kawahara K, Torii T, Tanoue A
J Neurosci. 2011
PubMed ID: 21880919
Genetic deletion of cdc42 reveals a crucial role for astrocyte recruitment to the injury site in vitro and in vivo.
Robel S, Bardehle S, Lepier A, Brakebusch C, Götz M
J Neurosci. 2011
PubMed ID: 21880909
Cdc42 controls vascular network assembly through protein kinase Cι during embryonic vasculogenesis.
Qi Y, Liu J, Wu X, Brakebusch C, Leitges M, Han Y, Corbett SA, Lowry SF, Graham AM, Li S
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21659643
A switch I mutant of Cdc42 exhibits less conformational freedom.
Chandrashekar R, Salem O, Krizova H, McFeeters R, Adams PD
Biochemistry. 2011
PubMed ID: 21667996
Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors.
Kulkarni K, Yang J, Zhang Z, Barford D
J Biol Chem. 2011
PubMed ID: 21613211
Modulation of dendritic spines and synaptic function by Rac1: a possible link to Fragile X syndrome pathology.
Bongmba OY, Martinez LA, Elhardt ME, Butler K, Tejada-Simon MV
Brain Res. 2011
PubMed ID: 21645877
RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.
Calvo F, Sanz-Moreno V, Agudo-Ibáñez L, Wallberg F, Sahai E, Marshall CJ, Crespo P
Nat Cell Biol. 2011
PubMed ID: 21685891
Promyogenic function of Integrin/FAK signaling is mediated by Cdo, Cdc42 and MyoD.
Han JW, Lee HJ, Bae GU, Kang JS
Cell Signal. 2011
PubMed ID: 21397010
miR-137 is frequently down-regulated in gastric cancer and is a negative regulator of Cdc42.
Chen Q, Chen X, Zhang M, Fan Q, Luo S, Cao X
Dig Dis Sci. 2011
PubMed ID: 21221794
Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.
Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R
J Cell Biol. 2011
PubMed ID: 21690310
Interaction of the Salmonella Typhimurium effector protein SopB with host cell Cdc42 is involved in intracellular replication.
Rodríguez-Escudero I, Ferrer NL, Rotger R, Cid VJ, Molina M
Mol Microbiol. 2011
PubMed ID: 21435037
RhoB links PDGF signaling to cell migration by coordinating activation and localization of Cdc42 and Rac.
Huang M, Satchell L, Duhadaway JB, Prendergast GC, Laury-Kleintop LD
J Cell Biochem. 2011
PubMed ID: 21344485
Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation.
Katayama K, Melendez J, Baumann JM, Leslie JR, Chauhan BK, Nemkul N, Lang RA, Kuan CY, Zheng Y, Yoshida Y
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21502507
Differential role of Rho GTPases in intestinal epithelial barrier regulation in vitro.
Schlegel N, Meir M, Spindler V, Germer CT, Waschke J
J Cell Physiol. 2011
PubMed ID: 20945370
Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors.
Goh WI, Sudhaharan T, Lim KB, Sem KP, Lau CL, Ahmed S
J Biol Chem. 2011
PubMed ID: 21339294
Local, persistent activation of Rho GTPases during plasticity of single dendritic spines.
Murakoshi H, Wang H, Yasuda R
Nature. 2011
PubMed ID: 21423166
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21421844
The cerebrospinal fluid provides a proliferative niche for neural progenitor cells.
Lehtinen MK, Zappaterra MW, Chen X, Yang YJ, Hill AD, Lun M, Maynard T, Gonzalez D, Kim S, Ye P, D'Ercole AJ, Wong ET, LaMantia AS, Walsh CA
Neuron. 2011
PubMed ID: 21382550
The Cdc42 guanine nucleotide exchange factor FGD1 regulates osteogenesis in human mesenchymal stem cells.
Gao L, Gorski JL, Chen CS
Am J Pathol. 2011
PubMed ID: 21356349
CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck.
Zhao ZJ, Liu FY, Li P, Ding X, Zong ZH, Sun CF
Oncol Rep. 2011
PubMed ID: 21165582
miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells.
Liu M, Lang N, Chen X, Tang Q, Liu S, Huang J, Zheng Y, Bi F
Cancer Lett. 2011
PubMed ID: 21186079
Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration.
Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M
EMBO J. 2011
PubMed ID: 21240187
N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity.
Hua KT, Tan CT, Johansson G, Lee JM, Yang PW, Lu HY, Chen CK, Su JL, Chen PB, Wu YL, Chi CC, Kao HJ, Shih HJ, Chen MW, Chien MH, Chen PS, Lee WJ, Cheng TY, Rosenberger G, Chai CY, Yang CJ, Huang MS, Lai TC, Chou TY, Hsiao M, Kuo ML
Cancer Cell. 2011
PubMed ID: 21295525
Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice.
Khan OM, Ibrahim MX, Jonsson IM, Karlsson C, Liu M, Sjogren AK, Olofsson FJ, Brisslert M, Andersson S, Ohlsson C, Hultén LM, Bokarewa M, Bergo MO
J Clin Invest. 2011
PubMed ID: 21266780
Signaling role of Cdc42 in regulating mammalian physiology.
Melendez J, Grogg M, Zheng Y
J Biol Chem. 2011
PubMed ID: 21115489
Invasion of breast cancer cells into collagen matrix requires TGF-α and Cdc42 signaling.
Kikuchi K, Li X, Zheng Y, Takano Y
FEBS Lett. 2011
PubMed ID: 21167153
The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.
Oliver AW, He X, Borthwick K, Donne AJ, Hampson L, Hampson IN
Br J Cancer. 2011
PubMed ID: 21139582
Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors.
Heynen SR, Tanimoto N, Joly S, Seeliger MW, Samardzija M, Grimm C
Mol Vis. 2011
PubMed ID: 22128240
Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation.
Akbar H, Shang X, Perveen R, Berryman M, Funk K, Johnson JF, Tandon NN, Zheng Y
PLoS One. 2011
PubMed ID: 21789221
Rho GTPases in hematopoietic stem/progenitor cell migration.
Liu W, Feng Y, Shang X, Zheng Y
Methods Mol Biol. 2011
PubMed ID: 21618100
Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation.
Guo F, Zhang S, Tripathi P, Mattner J, Phelan J, Sproles A, Mo J, Wills-Karp M, Grimes HL, Hildeman D, Zheng Y
PLoS One. 2011
PubMed ID: 21455314
Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization.
Sudhaharan T, Goh WI, Sem KP, Lim KB, Bu W, Ahmed S
PLoS One. 2011
PubMed ID: 21311754
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.
Li D, Hallett MA, Zhu W, Rubart M, Liu Y, Yang Z, Chen H, Haneline LS, Chan RJ, Schwartz RJ, Field LJ, Atkinson SJ, Shou W
Development. 2011
PubMed ID: 21177343
Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42.
Navarro A, Perez RE, Rezaiekhaligh MH, Mabry SM, Ekekezie II
Am J Physiol Lung Cell Mol Physiol. 2011
PubMed ID: 21036919
Cdc42-mediated inhibition of GSK-3β improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis.
Hoang MV, Nagy JA, Senger DR
Microvasc Res. 2011
PubMed ID: 20849862
Cdc42 localization and cell polarity depend on membrane traffic.
Osmani N, Peglion F, Chavrier P, Etienne-Manneville S
J Cell Biol. 2010
PubMed ID: 21173111
Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.
Vaz Meirelles G, Ferreira Lanza DC, da Silva JC, Santana Bernachi J, Paes Leme AF, Kobarg J
J Proteome Res. 2010
PubMed ID: 20873783
Cdc42 and Gsk3 modulate the dynamics of radial glial growth, inter-radial glial interactions and polarity in the developing cerebral cortex.
Yokota Y, Eom TY, Stanco A, Kim WY, Rao S, Snider WD, Anton ES
Development. 2010
PubMed ID: 21062867
Cdc42-mediated MTOC polarization in dendritic cells controls targeted delivery of cytokines at the immune synapse.
Pulecio J, Petrovic J, Prete F, Chiaruttini G, Lennon-Dumenil AM, Desdouets C, Gasman S, Burrone OR, Benvenuti F
J Exp Med. 2010
PubMed ID: 21059854
Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation.
Leemhuis J, Bouché E, Frotscher M, Henle F, Hein L, Herz J, Meyer DK, Pichler M, Roth G, Schwan C, Bock HH
J Neurosci. 2010
PubMed ID: 21048135
Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.
Guo F, Hildeman D, Tripathi P, Velu CS, Grimes HL, Zheng Y
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20937872
A human MAP kinase interactome.
Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
Nat Methods. 2010
PubMed ID: 20936779
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.
Ryan MA, Nattamai KJ, Xing E, Schleimer D, Daria D, Sengupta A, Köhler A, Liu W, Gunzer M, Jansen M, Ratner N, Le Cras TD, Waterstrat A, Van Zant G, Cancelas JA, Zheng Y, Geiger H
Nat Med. 2010
PubMed ID: 20871610
Sphingomyelin is important for the cellular entry and intracellular localization of Helicobacter pylori VacA.
Gupta VR, Wilson BA, Blanke SR
Cell Microbiol. 2010
PubMed ID: 20545942
HER2/ErbB2-induced breast cancer cell migration and invasion require p120 catenin activation of Rac1 and Cdc42.
Johnson E, Seachrist DD, DeLeon-Rodriguez CM, Lozada KL, Miedler J, Abdul-Karim FW, Keri RA
J Biol Chem. 2010
PubMed ID: 20595387
Effect of microRNA-206 on cytoskeleton remodelling by downregulating Cdc42 in MDA-MB-231 cells.
Liu H, Cao YD, Ye WX, Sun YY
Tumori. 2010
PubMed ID: 21302623
Cas utilizes Nck2 to activate Cdc42 and regulate cell polarization during cell migration in response to wound healing.
Funasaka K, Ito S, Hasegawa H, Goldberg GS, Hirooka Y, Goto H, Hamaguchi M, Senga T
FEBS J. 2010
PubMed ID: 20637038
Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B.
Wallace SW, Durgan J, Jin D, Hall A
Mol Biol Cell. 2010
PubMed ID: 20631255
Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1.
Larson Y, Liu J, Stevens PD, Li X, Li J, Evers BM, Gao T
J Biol Chem. 2010
PubMed ID: 20530489
Transience in polarization of cytolytic effectors is required for efficient killing and controlled by Cdc42.
Sinai P, Nguyen C, Schatzle JD, Wülfing C
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20547841
Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events.
Sacharidou A, Koh W, Stratman AN, Mayo AM, Fisher KE, Davis GE
Blood. 2010
PubMed ID: 20215637
Regulation of blood-testis barrier dynamics by TGF-beta3 is a Cdc42-dependent protein trafficking event.
Wong EW, Mruk DD, Lee WM, Cheng CY
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20534521
Cdx2 regulates endo-lysosomal function and epithelial cell polarity.
Gao N, Kaestner KH
Genes Dev. 2010
PubMed ID: 20551175
Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization.
Ito Y, Teitelbaum SL, Zou W, Zheng Y, Johnson JF, Chappel J, Ross FP, Zhao H
J Clin Invest. 2010
PubMed ID: 20501942
Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB
Cancer Prev Res (Phila Pa). 2010
PubMed ID: 20403997
Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets.
Pleines I, Eckly A, Elvers M, Hagedorn I, Eliautou S, Bender M, Wu X, Lanza F, Gachet C, Brakebusch C, Nieswandt B
Blood. 2010
PubMed ID: 20139097
Impaired NK-cell migration in WAS/XLT patients: role of Cdc42/WASp pathway in the control of chemokine-induced beta2 integrin high-affinity state.
Stabile H, Carlino C, Mazza C, Giliani S, Morrone S, Notarangelo LD, Notarangelo LD, Santoni A, Gismondi A
Blood. 2010
PubMed ID: 20130240
PH-domain-driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering.
Reddy-Alla S, Schmitt B, Birkenfeld J, Eulenburg V, Dutertre S, Böhringer C, Götz M, Betz H, Papadopoulos T
Eur J Neurosci. 2010
PubMed ID: 20345913
Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications.
Jiang XS, Wassif CA, Backlund PS, Song L, Holtzclaw LA, Li Z, Yergey AL, Porter FD
Hum Mol Genet. 2010
PubMed ID: 20067919
Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LA, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S
Vaccine. 2010
PubMed ID: 20056178
HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.
Lin Q, Wang J, Childress C, Sudol M, Carey DJ, Yang W
Mol Cell Biol. 2010
PubMed ID: 20086093
A Cdc42 activation cycle coordinated by PI 3-kinase during Fc receptor-mediated phagocytosis.
Beemiller P, Zhang Y, Mohan S, Levinsohn E, Gaeta I, Hoppe AD, Swanson JA
Mol Biol Cell. 2010
PubMed ID: 19955216
Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization.
Robens JM, Yeow-Fong L, Ng E, Hall C, Manser E
Mol Cell Biol. 2010
PubMed ID: 19933840
Genomic assessment of follicular marker genes as pregnancy predictors for human IVF.
Hamel M, Dufort I, Robert C, Léveillé MC, Leader A, Sirard MA
Mol Hum Reprod. 2010
PubMed ID: 19778949
Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture.
Duan L, Chen G, Virmani S, Ying G, Raja SM, Chung BM, Rainey MA, Dimri M, Ortega-Cava CF, Zhao X, Clubb RJ, Tu C, Reddi AL, Naramura M, Band V, Band H
J Biol Chem. 2010
PubMed ID: 19826000
Two novel human NUMB isoforms provide a potential link between development and cancer.
Karaczyn A, Bani-Yaghoub M, Tremblay R, Kubu C, Cowling R, Adams TL, Prudovsky I, Spicer D, Friesel R, Vary C, Verdi JM
Neural Dev. 2010
PubMed ID: 21122105
Host genetic factors and vaccine-induced immunity to HBV infection: haplotype analysis.
Ryckman KK, Fielding K, Hill AV, Mendy M, Rayco-Solon P, Sirugo G, van der Sande MA, Waight P, Whittle HC, Hall AJ, Williams SM, Hennig BJ
PLoS One. 2010
PubMed ID: 20806065
Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosis.
Bu W, Lim KB, Yu YH, Chou AM, Sudhaharan T, Ahmed S
PLoS One. 2010
PubMed ID: 20730103
Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts.
Appledorn DM, Dao KH, O'Reilly S, Maher VM, McCormick JJ
BMC Cancer. 2010
PubMed ID: 20067638
MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices.
Fisher KE, Sacharidou A, Stratman AN, Mayo AM, Fisher SB, Mahan RD, Davis MJ, Davis GE
J Cell Sci. 2009
PubMed ID: 19934222
The rho guanosine 5'-triphosphatase, cell division cycle 42, is required for insulin-induced actin remodeling and glucagon-like peptide-1 secretion in the intestinal endocrine L cell.
Lim GE, Xu M, Sun J, Jin T, Brubaker PL
Endocrinology. 2009
PubMed ID: 19819966
Cross-talk between Rac1 and Cdc42 GTPases regulates formation of filopodia required for dengue virus type-2 entry into HMEC-1 cells.
Zamudio-Meza H, Castillo-Alvarez A, González-Bonilla C, Meza I
J Gen Virol. 2009
PubMed ID: 19710257
Serine-71 phosphorylation of Rac1/Cdc42 diminishes the pathogenic effect of Clostridium difficile toxin A.
Schoentaube J, Olling A, Tatge H, Just I, Gerhard R
Cell Microbiol. 2009
PubMed ID: 19709124
p210(Bcr-Abl) desensitizes Cdc42 GTPase signaling for SDF-1alpha-directed migration in chronic myeloid leukemia cells.
Chang YC, Tien SC, Tien HF, Zhang H, Bokoch GM, Chang ZF
Oncogene. 2009
PubMed ID: 19718053
Cdc42-mediated tubulogenesis controls cell specification.
Kesavan G, Sand FW, Greiner TU, Johansson JK, Kobberup S, Wu X, Brakebusch C, Semb H
Cell. 2009
PubMed ID: 19914171
The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling.
Szczur K, Zheng Y, Filippi MD
Blood. 2009
PubMed ID: 19752396
Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination.
Chauhan BK, Disanza A, Choi SY, Faber SC, Lou M, Beggs HE, Scita G, Zheng Y, Lang RA
Development. 2009
PubMed ID: 19820184
Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages.
Dovas A, Gevrey JC, Grossi A, Park H, Abou-Kheir W, Cox D
J Cell Sci. 2009
PubMed ID: 19808890
Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase.
Araya N, Arimura H, Kawahara K, Yagishita N, Ishida J, Fujii R, Aratani S, Fujita H, Sato T, Yamano Y, Higuchi I, Osame M, Nishioka K, Fukamizu A, Arimura K, Maruyama I, Nakajima T
Int J Mol Med. 2009
PubMed ID: 19787194
Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP.
Park H, Cox D
Mol Biol Cell. 2009
PubMed ID: 19741094
A novel function of heparan sulfate in the regulation of cell-cell fusion.
O'Donnell CD, Shukla D
J Biol Chem. 2009
PubMed ID: 19726670
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
Nishiyama A, Xin L, Sharov AA, Thomas M, Mowrer G, Meyers E, Piao Y, Mehta S, Yee S, Nakatake Y, Stagg C, Sharova L, Correa-Cerro LS, Bassey U, Hoang H, Kim E, Tapnio R, Qian Y, Dudekula D, Zalzman M, Li M, Falco G, Yang HT, Lee SL, Monti M, Stanghellini I, Islam MN, Nagaraja R, Goldberg I, Wang W, Longo DL, Schlessinger D, Ko MS
Cell Stem Cell. 2009
PubMed ID: 19796622
Cdc42 is an antihypertrophic molecular switch in the mouse heart.
Maillet M, Lynch JM, Sanna B, York AJ, Zheng Y, Molkentin JD
J Clin Invest. 2009
PubMed ID: 19741299
Kainic acid-induced F-344 rat model of mesial temporal lobe epilepsy: gene expression and canonical pathways.
Sharma AK, Searfoss GH, Reams RY, Jordan WH, Snyder PW, Chiang AY, Jolly RA, Ryan TP
Toxicol Pathol. 2009
PubMed ID: 19700661
Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors.
Calvo F, Crespo P
Mol Biol Cell. 2009
PubMed ID: 19692568
Rho GTPase Cdc42 is essential for B-lymphocyte development and activation.
Guo F, Velu CS, Grimes HL, Zheng Y
Blood. 2009
PubMed ID: 19671922
Impact of Rac1 and Cdc42 signaling during early herpes simplex virus type 1 infection of keratinocytes.
Petermann P, Haase I, Knebel-Mörsdorf D
J Virol. 2009
PubMed ID: 19640983
Actin dynamics and Rho GTPases regulate the size and formation of parasitophorous vacuoles containing Coxiella burnetii.
Aguilera M, Salinas R, Rosales E, Carminati S, Colombo MI, Berón W
Infect Immun. 2009
PubMed ID: 19635823
Bone marrow progenitor cells induce endothelial adherens junction integrity by sphingosine-1-phosphate-mediated Rac1 and Cdc42 signaling.
Zhao YD, Ohkawara H, Rehman J, Wary KK, Vogel SM, Minshall RD, Zhao YY, Malik AB
Circ Res. 2009
PubMed ID: 19696411
Intersectin-2L regulates caveola endocytosis secondary to Cdc42-mediated actin polymerization.
Klein IK, Predescu DN, Sharma T, Knezevic I, Malik AB, Predescu S
J Biol Chem. 2009
PubMed ID: 19622753
Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.
Yang J, Zhang Z, Roe SM, Marshall CJ, Barford D
Science. 2009
PubMed ID: 19745154
Coordination of Rho GTPase activities during cell protrusion.
Machacek M, Hodgson L, Welch C, Elliott H, Pertz O, Nalbant P, Abell A, Johnson GL, Hahn KM, Danuser G
Nature. 2009
PubMed ID: 19693013
Regulation of cell death by recycling endosomes and golgi membrane dynamics via a pathway involving Src-family kinases, Cdc42 and Rab11a.
Landry MC, Sicotte A, Champagne C, Lavoie JN
Mol Biol Cell. 2009
PubMed ID: 19641023
Genes regulating molecular and cellular functions in noninfectious nonallergic rhinitis.
Cardell LO, Andersson M, Cervin A, Davidsson A, Hellgren J, Holmström M, Lundblad L, Stierna P, Stjärne P, Adner M, SRFA study group
Allergy. 2009
PubMed ID: 19432938
The mechanism of CSF-1-induced Wiskott-Aldrich syndrome protein activation in vivo: a role for phosphatidylinositol 3-kinase and Cdc42.
Cammer M, Gevrey JC, Lorenz M, Dovas A, Condeelis J, Cox D
J Biol Chem. 2009
PubMed ID: 19561083
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1.
Nakamura N, Naruse K, Matsuki T, Hamada Y, Nakashima E, Kamiya H, Matsubara T, Enomoto A, Takahashi M, Oiso Y, Nakamura J
FEBS Lett. 2009
PubMed ID: 19596003
Cadherin-cadherin engagement promotes cell survival via Rac1/Cdc42 and signal transducer and activator of transcription-3.
Arulanandam R, Vultur A, Cao J, Carefoot E, Elliott BE, Truesdell PF, Larue L, Feracci H, Raptis L
Mol Cancer Res. 2009
PubMed ID: 19671682
Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.
Comabella M, Craig DW, Morcillo-Suárez C, Río J, Navarro A, Fernández M, Martin R, Montalban X
Arch Neurol. 2009
PubMed ID: 19667218
Cdc42 and the phosphatidylinositol 3-kinase-Akt pathway are essential for PspC-mediated internalization of pneumococci by respiratory epithelial cells.
Agarwal V, Hammerschmidt S
J Biol Chem. 2009
PubMed ID: 19473971
Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway.
Oh JE, Bae GU, Yang YJ, Yi MJ, Lee HJ, Kim BG, Krauss RS, Kang JS
FASEB J. 2009
PubMed ID: 19244314
IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway.
Wang JB, Sonn R, Tekletsadik YK, Samorodnitsky D, Osman MA
J Cell Sci. 2009
PubMed ID: 19454477
Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration.
Lämmermann T, Renkawitz J, Wu X, Hirsch K, Brakebusch C, Sixt M
Blood. 2009
PubMed ID: 19190242
The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse.
Vasyutina E, Martarelli B, Brakebusch C, Wende H, Birchmeier C
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19443691
Formation of endothelial lumens requires a coordinated PKCepsilon-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation.
Koh W, Sachidanandam K, Stratman AN, Sacharidou A, Mayo AM, Murphy EA, Cheresh DA, Davis GE
J Cell Sci. 2009
PubMed ID: 19435802
Integrating receptor signal inputs that influence small Rho GTPase activation dynamics at the immunological synapse.
Makrogianneli K, Carlin LM, Keppler MD, Matthews DR, Ofo E, Coolen A, Ameer-Beg SM, Barber PR, Vojnovic B, Ng T
Mol Cell Biol. 2009
PubMed ID: 19307303
The type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrestin2-mediated activation of Cdc42.
Mythreye K, Blobe GC
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19416857
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis.
Monypenny J, Zicha D, Higashida C, Oceguera-Yanez F, Narumiya S, Watanabe N
Mol Cell Biol. 2009
PubMed ID: 19273601
Dual role of Cdc42 in spindle orientation control of adherent cells.
Mitsushima M, Toyoshima F, Nishida E
Mol Cell Biol. 2009
PubMed ID: 19273597
Essential role of Rac1 and Rac3 GTPases in neuronal development.
Corbetta S, Gualdoni S, Ciceri G, Monari M, Zuccaro E, Tybulewicz VL, de Curtis I
FASEB J. 2009
PubMed ID: 19126596
Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1.
Du D, Pedersen E, Wang Z, Karlsson R, Chen Z, Wu X, Brakebusch C
Exp Cell Res. 2009
PubMed ID: 19100259
The fic domain: regulation of cell signaling by adenylylation.
Worby CA, Mattoo S, Kruger RP, Corbeil LB, Koller A, Mendez JC, Zekarias B, Lazar C, Dixon JE
Mol Cell. 2009
PubMed ID: 19362538
Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system.
Pereira JA, Benninger Y, Baumann R, Gonçalves AF, Ozçelik M, Thurnherr T, Tricaud N, Meijer D, Fässler R, Suter U, Relvas JB
J Cell Biol. 2009
PubMed ID: 19349584
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.
Sawallisch C, Berhörster K, Disanza A, Mantoani S, Kintscher M, Stoenica L, Dityatev A, Sieber S, Kindler S, Morellini F, Schweizer M, Boeckers TM, Korte M, Scita G, Kreienkamp HJ
J Biol Chem. 2009
PubMed ID: 19208628
Rab35 regulates neurite outgrowth and cell shape.
Chevallier J, Koop C, Srivastava A, Petrie RJ, Lamarche-Vane N, Presley JF
FEBS Lett. 2009
PubMed ID: 19289122
T-cadherin activates Rac1 and Cdc42 and changes endothelial permeability.
Semina EV, Rubina KA, Rutkevich PN, Voyno-Yasenetskaya TA, Parfyonova YV, Tkachuk VA
Biochemistry (Mosc). 2009
PubMed ID: 19463088
The bacterial virulence factor lymphostatin compromises intestinal epithelial barrier function by modulating rho GTPases.
Babbin BA, Sasaki M, Gerner-Schmidt KW, Nusrat A, Klapproth JM
Am J Pathol. 2009
PubMed ID: 19286565
Characterisation of the nucleotide exchange factor ITSN1L: evidence for a kinetic discrimination of GEF-stimulated nucleotide release from Cdc42.
Kintscher C, Groemping Y
J Mol Biol. 2009
PubMed ID: 19356586
Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1.
Fuchs S, Herzog D, Sumara G, Büchmann-Møller S, Civenni G, Wu X, Chrostek-Grashoff A, Suter U, Ricci R, Relvas JB, Brakebusch C, Sommer L
Cell Stem Cell. 2009
PubMed ID: 19265663
Cdc42-mTOR signaling pathway controls Hes5 and Pax6 expression in retinoic acid-dependent neural differentiation.
Endo M, Antonyak MA, Cerione RA
J Biol Chem. 2009
PubMed ID: 19097998
GM130-dependent control of Cdc42 activity at the Golgi regulates centrosome organization.
Kodani A, Kristensen I, Huang L, Sütterlin C
Mol Biol Cell. 2009
PubMed ID: 19109421
AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling.
Yarbrough ML, Li Y, Kinch LN, Grishin NV, Ball HL, Orth K
Science. 2009
PubMed ID: 19039103
Critical involvement of Rho GTPase activity in the efficient transplantation of neural stem cells into the injured spinal cord.
Numano F, Inoue A, Enomoto M, Shinomiya K, Okawa A, Okabe S
Mol Brain. 2009
PubMed ID: 19943951
Mapping cofilin-actin rods in stressed hippocampal slices and the role of cdc42 in amyloid-beta-induced rods.
Davis RC, Maloney MT, Minamide LS, Flynn KC, Stonebraker MA, Bamburg JR
J Alzheimers Dis. 2009
PubMed ID: 19542631
Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation.
Hughes DS, Keynes RJ, Tannahill D
BMC Dev Biol. 2009
PubMed ID: 19463158
Tubulin tyrosination is required for the proper organization and pathfinding of the growth cone.
Marcos S, Moreau J, Backer S, Job D, Andrieux A, Bloch-Gallego E
PLoS One. 2009
PubMed ID: 19404406
Calcium-regulated exocytosis in neuroendocrine cells: intersectin-1L stimulates actin polymerization and exocytosis by activating Cdc42.
Momboisse F, Ory S, Calco V, Malacombe M, Bader MF, Gasman S
Ann N Y Acad Sci. 2009
PubMed ID: 19161392
Specificity of interactions between mDia isoforms and Rho proteins.
Lammers M, Meyer S, Kühlmann D, Wittinghofer A
J Biol Chem. 2008
PubMed ID: 18829452
Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42.
Hudson BI, Kalea AZ, Del Mar Arriero M, Harja E, Boulanger E, D'Agati V, Schmidt AM
J Biol Chem. 2008
PubMed ID: 18922799
microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart.
Liu N, Bezprozvannaya S, Williams AH, Qi X, Richardson JA, Bassel-Duby R, Olson EN
Genes Dev. 2008
PubMed ID: 19015276
BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity.
Gamell C, Osses N, Bartrons R, Rückle T, Camps M, Rosa JL, Ventura F
J Cell Sci. 2008
PubMed ID: 19001503
Proteomic profiling reveals the prognostic value of adenomatous polyposis coli-end-binding protein 1 in hepatocellular carcinoma.
Orimo T, Ojima H, Hiraoka N, Saito S, Kosuge T, Kakisaka T, Yokoo H, Nakanishi K, Kamiyama T, Todo S, Hirohashi S, Kondo T
Hepatology. 2008
PubMed ID: 18937283
Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture.
Chen Y, Stump RJ, Lovicu FJ, Shimono A, McAvoy JW
Dev Biol. 2008
PubMed ID: 18824165
Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis.
Jaffe AB, Kaji N, Durgan J, Hall A
J Cell Biol. 2008
PubMed ID: 19001128
The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation.
Ambrogio C, Voena C, Manazza AD, Martinengo C, Costa C, Kirchhausen T, Hirsch E, Inghirami G, Chiarle R
Cancer Res. 2008
PubMed ID: 18974134
DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells.
Gadea G, Sanz-Moreno V, Self A, Godi A, Marshall CJ
Curr Biol. 2008
PubMed ID: 18835169
ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity.
Wu X, Kodama A, Fuchs E
Cell. 2008
PubMed ID: 18854161
Microarray and pathway analysis reveals decreased CDC25A and increased CDC42 associated with slow growth of BCL2 overexpressing immortalized breast cell line.
Long JM, Bell CW, Fagg WS, Kushman ME, Becker KG, McCubrey JA, Farwell MA
Cell Cycle. 2008
PubMed ID: 18838868
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Distribution of small Rho GTPases in the developing rat submandibular gland.
Crema VO, Fossati AC, Hamassaki DE, Santos MF
J Mol Histol. 2008
PubMed ID: 18784978
Cdc42 protein acts upstream of IQGAP1 and regulates cytokinesis in mouse oocytes and embryos.
Bielak-Zmijewska A, Kolano A, Szczepanska K, Maleszewski M, Borsuk E
Dev Biol. 2008
PubMed ID: 18662680
The C-terminus of IpaC is required for effector activities related to Shigella invasion of host cells.
Terry CM, Picking WL, Birket SE, Flentie K, Hoffman BM, Barker JR, Picking WD
Microb Pathog. 2008
PubMed ID: 18656530
PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway.
Chan PM, Lim L, Manser E
J Biol Chem. 2008
PubMed ID: 18586681
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
Wang J, Yuan Y, Zhou Y, Guo L, Zhang L, Kuai X, Deng B, Pan Z, Li D, He F
J Proteome Res. 2008
PubMed ID: 18624398
Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A.
Zhang X, Shang X, Guo F, Murphy K, Kirby M, Kelly P, Reeves L, Smith FO, Williams DA, Zheng Y, Pang Q
Blood. 2008
PubMed ID: 18565850
Cdc42 and RhoA have opposing roles in regulating membrane type 1-matrix metalloproteinase localization and matrix metalloproteinase-2 activation.
Ispanovic E, Serio D, Haas TL
Am J Physiol Cell Physiol. 2008
PubMed ID: 18562481
IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade.
Nojima H, Adachi M, Matsui T, Okawa K, Tsukita S, Tsukita S
Nat Cell Biol. 2008
PubMed ID: 18604197
Critical role of Cdc42 in mediating endothelial barrier protection in vivo.
Ramchandran R, Mehta D, Vogel SM, Mirza MK, Kouklis P, Malik AB
Am J Physiol Lung Cell Mol Physiol. 2008
PubMed ID: 18515405
Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins.
Schnack C, Danzer KM, Hengerer B, Gillardon F
Neuroscience. 2008
PubMed ID: 18541383
Krüppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase.
Yang Y, Tetreault MP, Yermolina YA, Goldstein BG, Katz JP
J Biol Chem. 2008
PubMed ID: 18450752
Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism.
Gómez Del Pulgar T, Valdés-Mora F, Bandrés E, Pérez-Palacios R, Espina C, Cejas P, García-Cabezas MA, Nistal M, Casado E, González-Barón M, García-Foncillas J, Lacal JC
Int J Oncol. 2008
PubMed ID: 18575765
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.
Sakurai-Yageta M, Recchi C, Le Dez G, Sibarita JB, Daviet L, Camonis J, D'Souza-Schorey C, Chavrier P
J Cell Biol. 2008
PubMed ID: 18541705
Prostaglandin E2-mediated migration of human trophoblast requires RAC1 and CDC42.
Nicola C, Lala PK, Chakraborty C
Biol Reprod. 2008
PubMed ID: 18235104
Effector proteins exert an important influence on the signaling-active state of the small GTPase Cdc42.
Phillips MJ, Calero G, Chan B, Ramachandran S, Cerione RA
J Biol Chem. 2008
PubMed ID: 18348980
The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration.
Murakami M, Meneses PI, Lan K, Robertson ES
Cancer Biol Ther. 2008
PubMed ID: 18728402
PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex.
Nakamura T, Hayashi T, Nasu-Nishimura Y, Sakaue F, Morishita Y, Okabe T, Ohwada S, Matsuura K, Akiyama T
Genes Dev. 2008
PubMed ID: 18451111
Critical roles for the actin cytoskeleton and cdc42 in regulating platelet integrin alpha2beta1.
Pula G, Poole AW
Platelets. 2008
PubMed ID: 18432521
Role of TGF-beta1-independent changes in protein neosynthesis, p38alphaMAPK, and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis.
Chrétien A, Dierick JF, Delaive E, Larsen MR, Dieu M, Raes M, Deroanne CF, Roepstorff P, Toussaint O
Free Radic Biol Med. 2008
PubMed ID: 18325348
Identification of cognate host targets and specific ubiquitylation sites on the Salmonella SPI-1 effector SopB/SigD.
Rogers LD, Kristensen AR, Boyle EC, Robinson DP, Ly RT, Finlay BB, Foster LJ
J Proteomics. 2008
PubMed ID: 18541478
Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF
Black SA, Trackman PC
J Biol Chem. 2008
PubMed ID: 18287089
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells.
El-Sibai M, Pertz O, Pang H, Yip SC, Lorenz M, Symons M, Condeelis JS, Hahn KM, Backer JM
Exp Cell Res. 2008
PubMed ID: 18316075
MUC1 initiates Src-CrkL-Rac1/Cdc42-mediated actin cytoskeletal protrusive motility after ligating intercellular adhesion molecule-1.
Shen Q, Rahn JJ, Zhang J, Gunasekera N, Sun X, Shaw AR, Hendzel MJ, Hoffman P, Bernier A, Hugh JC
Mol Cancer Res. 2008
PubMed ID: 18403635
A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes.
Padmos RC, Hillegers MH, Knijff EM, Vonk R, Bouvy A, Staal FJ, de Ridder D, Kupka RW, Nolen WA, Drexhage HA
Arch Gen Psychiatry. 2008
PubMed ID: 18391128
Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling.
Koh W, Mahan RD, Davis GE
J Cell Sci. 2008
PubMed ID: 18319301
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells.
Shen Y, Li N, Wu S, Zhou Y, Shan Y, Zhang Q, Ding C, Yuan Q, Zhao F, Zeng R, Zhu X
Dev Cell. 2008
PubMed ID: 18331715
Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver.
van Hengel J, D'Hooge P, Hooghe B, Wu X, Libbrecht L, De Vos R, Quondamatteo F, Klempt M, Brakebusch C, van Roy F
Gastroenterology. 2008
PubMed ID: 18325391
Transcriptome and proteome analysis of early embryonic mouse brain development.
Hartl D, Irmler M, Römer I, Mader MT, Mao L, Zabel C, de Angelis MH, Beckers J, Klose J
Proteomics. 2008
PubMed ID: 18283662
Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src-mediated pathway.
Shen Y, Hirsch DS, Sasiela CA, Wu WJ
J Biol Chem. 2008
PubMed ID: 18057010
Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network.
Pertz OC, Wang Y, Yang F, Wang W, Gay LJ, Gristenko MA, Clauss TR, Anderson DJ, Liu T, Auberry KJ, Camp DG, Smith RD, Klemke RL
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18245386
Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors.
Kwofie MA, Skowronski J
J Biol Chem. 2008
PubMed ID: 18056264
The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity.
Zhang S, Schafer-Hales K, Khuri FR, Zhou W, Vertino PM, Marcus AI
Cancer Res. 2008
PubMed ID: 18245474
An immune escape screen reveals Cdc42 as regulator of cancer susceptibility to lymphocyte-mediated tumor suppression.
Marques CA, Hähnel PS, Wölfel C, Thaler S, Huber C, Theobald M, Schuler M
Blood. 2008
PubMed ID: 17971488
Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42.
Ueda H, Nagae R, Kozawa M, Morishita R, Kimura S, Nagase T, Ohara O, Yoshida S, Asano T
J Biol Chem. 2008
PubMed ID: 18045877
Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease.
Li Y, Rowland C, Xiromerisiou G, Lagier RJ, Schrodi SJ, Dradiotis E, Ross D, Bui N, Catanese J, Aggelakis K, Grupe A, Hadjigeorgiou G
PLoS ONE. 2008
PubMed ID: 18628988
HTLV-I production based on activation of integrin/ligand signaling in HTLV-I-infected T cell lines derived from HAM/TSP patients.
Fukushima N, Nakamura T, Nishiura Y, Ida H, Aramaki T, Eguchi K
Intervirology. 2008
PubMed ID: 18552504
[The Rho protein family and its role in the cellular cytoskeleton]
Nowak JM, Grzanka A, Zuryń A, Stepień A
Postepy Hig Med Dosw (Online). 2008
PubMed ID: 18334926
START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology.
Kawai K, Kiyota M, Seike J, Deki Y, Yagisawa H
Biochem Biophys Res Commun. 2007
PubMed ID: 17976533
Formyl peptide receptor-1 activation enhances intestinal epithelial cell restitution through phosphatidylinositol 3-kinase-dependent activation of Rac1 and Cdc42.
Babbin BA, Jesaitis AJ, Ivanov AI, Kelly D, Laukoetter M, Nava P, Parkos CA, Nusrat A
J Immunol. 2007
PubMed ID: 18056353
Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.
Yang L, Wang L, Kalfa TA, Cancelas JA, Shang X, Pushkaran S, Mo J, Williams DA, Zheng Y
Blood. 2007
PubMed ID: 17702896
Cdc42 regulates cofilin during the establishment of neuronal polarity.
Garvalov BK, Flynn KC, Neukirchen D, Meyn L, Teusch N, Wu X, Brakebusch C, Bamburg JR, Bradke F
J Neurosci. 2007
PubMed ID: 18045906
Class A scavenger receptor-mediated macrophage adhesion requires coupling of calcium-independent phospholipase A(2) and 12/15-lipoxygenase to Rac and Cdc42 activation.
Nikolic DM, Gong MC, Turk J, Post SR
J Biol Chem. 2007
PubMed ID: 17873277
Regulation of ephexin1, a guanine nucleotide exchange factor of Rho family GTPases, by fibroblast growth factor receptor-mediated tyrosine phosphorylation.
Zhang Y, Sawada T, Jing X, Yokote H, Yan X, Sakaguchi K
J Biol Chem. 2007
PubMed ID: 17702745
IQGAP1 regulates Salmonella invasion through interactions with actin, Rac1, and Cdc42.
Brown MD, Bry L, Li Z, Sacks DB
J Biol Chem. 2007
PubMed ID: 17693642
Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells.
El-Sibai M, Nalbant P, Pang H, Flinn RJ, Sarmiento C, Macaluso F, Cammer M, Condeelis JS, Hahn KM, Backer JM
J Cell Sci. 2007
PubMed ID: 17855387
Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development.
Wu X, Li S, Chrostek-Grashoff A, Czuchra A, Meyer H, Yurchenco PD, Brakebusch C
Dev Dyn. 2007
PubMed ID: 17849438
Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways.
Bosse T, Ehinger J, Czuchra A, Benesch S, Steffen A, Wu X, Schloen K, Niemann HH, Scita G, Stradal TE, Brakebusch C, Rottner K
Mol Cell Biol. 2007
PubMed ID: 17682062
Role of the small Rho GTPases Rac1 and Cdc42 in host cell invasion of Campylobacter jejuni.
Krause-Gruszczynska M, Rohde M, Hartig R, Genth H, Schmidt G, Keo T, König W, Miller WG, Konkel ME, Backert S
Cell Microbiol. 2007
PubMed ID: 17521326
Trio controls the mature organization of neuronal clusters in the hindbrain.
Backer S, Hidalgo-Sánchez M, Offner N, Portales-Casamar E, Debant A, Fort P, Gauthier-Rouvière C, Bloch-Gallego E
J Neurosci. 2007
PubMed ID: 17898204
Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.
Atwood SX, Chabu C, Penkert RR, Doe CQ, Prehoda KE
J Cell Sci. 2007
PubMed ID: 17726059
Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis.
Woods A, Wang G, Dupuis H, Shao Z, Beier F
J Biol Chem. 2007
PubMed ID: 17573353
Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.
Prag S, Parsons M, Keppler MD, Ameer-Beg SM, Barber P, Hunt J, Beavil AJ, Calvert R, Arpin M, Vojnovic B, Ng T
Mol Biol Cell. 2007
PubMed ID: 17538024
The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42.
Rosário M, Franke R, Bednarski C, Birchmeier W
J Cell Biol. 2007
PubMed ID: 17664338
The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway.
Kreis P, Thévenot E, Rousseau V, Boda B, Muller D, Barnier JV
J Biol Chem. 2007
PubMed ID: 17537723
Activation of p61Hck triggers WASp- and Arp2/3-dependent actin-comet tail biogenesis and accelerates lysosomes.
Vincent C, Maridonneau-Parini I, Le Clainche C, Gounon P, Labrousse A
J Biol Chem. 2007
PubMed ID: 17500055
CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on phosphatidylinositol 3-kinase, Vav-1, Cdc42, and myosin light chain kinase.
Wei B, da Rocha Dias S, Wang H, Rudd CE
J Immunol. 2007
PubMed ID: 17579061
Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes.
Tsuritani K, Irie T, Yamashita R, Sakakibara Y, Wakaguri H, Kanai A, Mizushima-Sugano J, Sugano S, Nakai K, Suzuki Y
Genome Res. 2007
PubMed ID: 17567985
Effects of pharmacological inhibition of small GTPases on axon extension and migration of enteric neural crest-derived cells.
Stewart AL, Young HM, Popoff M, Anderson RB
Dev Biol. 2007
PubMed ID: 17524389
Rac1, RhoA, and Cdc42 participate in HeLa cell invasion by group B streptococcus.
Burnham CA, Shokoples SE, Tyrrell GJ
FEMS Microbiol Lett. 2007
PubMed ID: 17517067
Differential effects of phenylalanine on Rac1, Cdc42, and RhoA expression and activity in cultured cortical neurons.
Zhang Y, Zhang H, Yuan X, Gu X
Pediatr Res. 2007
PubMed ID: 17515837
Paxillin-beta-catenin interactions are involved in Rac/Cdc42-mediated endothelial barrier-protective response to oxidized phospholipids.
Birukova AA, Malyukova I, Poroyko V, Birukov KG
Am J Physiol Lung Cell Mol Physiol. 2007
PubMed ID: 17513457
Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.
Benninger Y, Thurnherr T, Pereira JA, Krause S, Wu X, Chrostek-Grashoff A, Herzog D, Nave KA, Franklin RJ, Meijer D, Brakebusch C, Suter U, Relvas JB
J Cell Biol. 2007
PubMed ID: 17576798
Inactivation of Cdc42 is necessary for depolymerization of phagosomal F-actin and subsequent phagosomal maturation.
Lerm M, Brodin VP, Ruishalme I, Stendahl O, Särndahl E
J Immunol. 2007
PubMed ID: 17513786
Cdc42 is implicated in polarity during meiotic resumption and blastocyst formation in the mouse.
Cui XS, Li XY, Kim NH
Mol Reprod Dev. 2007
PubMed ID: 17154294
Co-operative Cdc42 and Rho signalling mediates ephrinB-triggered endothelial cell retraction.
Groeger G, Nobes CD
Biochem J. 2007
PubMed ID: 17300218
MicroRNA-133 controls cardiac hypertrophy.
Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, Gallo P, Bang ML, Segnalini P, Gu Y, Dalton ND, Elia L, Latronico MV, Høydal M, Autore C, Russo MA, Dorn GW, Ellingsen O, Ruiz-Lozano P, Peterson KL, Croce CM, Peschle C, Condorelli G
Nat Med. 2007
PubMed ID: 17468766
Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not the RhoA GTPase.
Shi HY, Stafford LJ, Liu Z, Liu M, Zhang M
Cell Motil Cytoskeleton. 2007
PubMed ID: 17301947
Rho-family small GTPases are involved in forskolin-induced cell-cell contact formation of renal glomerular podocytes in vitro.
Gao SY, Li CY, Shimokawa T, Terashita T, Matsuda S, Yaoita E, Kobayashi N
Cell Tissue Res. 2007
PubMed ID: 17265067
Filopodia are induced by aquaporin-9 expression.
Loitto VM, Huang C, Sigal YJ, Jacobson K
Exp Cell Res. 2007
PubMed ID: 17346701
Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons.
Chen L, Liao G, Waclaw RR, Burns KA, Linquist D, Campbell K, Zheng Y, Kuan CY
J Neurosci. 2007
PubMed ID: 17409253
Gem associates with Ezrin and acts via the Rho-GAP protein Gmip to down-regulate the Rho pathway.
Hatzoglou A, Ader I, Splingard A, Flanders J, Saade E, Leroy I, Traver S, Aresta S, de Gunzburg J
Mol Biol Cell. 2007
PubMed ID: 17267693
Down-regulation Cdc42 attenuates neuronal apoptosis through inhibiting MLK3/JNK3 cascade during ischemic reperfusion in rat hippocampus.
Zhao J, Pei DS, Zhang QG, Zhang GY
Cell Signal. 2007
PubMed ID: 17161586
Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow.
Yang L, Wang L, Geiger H, Cancelas JA, Mo J, Zheng Y
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360364
Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells.
Azios NG, Krishnamoorthy L, Harris M, Cubano LA, Cammer M, Dharmawardhane SF
Neoplasia. 2007
PubMed ID: 17356711
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.
Martin-Belmonte F, Gassama A, Datta A, Yu W, Rescher U, Gerke V, Mostov K
Cell. 2007
PubMed ID: 17254974
Developmental expression of three small GTPases in the mouse eye.
Mitchell DC, Bryan BA, Liu JP, Liu WB, Zhang L, Qu J, Zhou X, Liu M, Li DW
Mol Vis. 2007
PubMed ID: 17653061
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development.
Singh S, Yin X, Pisano MM, Greene RM
Birth Defects Res A Clin Mol Teratol. 2007
PubMed ID: 17177285
Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration.
Osmani N, Vitale N, Borg JP, Etienne-Manneville S
Curr Biol. 2006
PubMed ID: 17081755
Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.
Modzelewska K, Newman LP, Desai R, Keely PJ
J Biol Chem. 2006
PubMed ID: 17038317
Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex.
Disanza A, Mantoani S, Hertzog M, Gerboth S, Frittoli E, Steffen A, Berhoerster K, Kreienkamp HJ, Milanesi F, Di Fiore PP, Ciliberto A, Stradal TE, Scita G
Nat Cell Biol. 2006
PubMed ID: 17115031
Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs.
Kostenko EV, Olabisi OO, Sahay S, Rodriguez PL, Whitehead IP
Mol Cell Biol. 2006
PubMed ID: 17000758
Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42.
Lin Q, Yang W, Baird D, Feng Q, Cerione RA
J Biol Chem. 2006
PubMed ID: 16968698
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Patel JC, Galán JE
J Cell Biol. 2006
PubMed ID: 17074883
Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts.
Yang L, Wang L, Zheng Y
Mol Biol Cell. 2006
PubMed ID: 16914516
Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly.
Chen L, Liao G, Yang L, Campbell K, Nakafuku M, Kuan CY, Zheng Y
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17050694
A PI3K activity-independent function of p85 regulatory subunit in control of mammalian cytokinesis.
García Z, Silio V, Marqués M, Cortés I, Kumar A, Hernandez C, Checa AI, Serrano A, Carrera AC
EMBO J. 2006
PubMed ID: 17024187
Cdc42 is involved in PKCepsilon- and delta-induced neurite outgrowth and stress fibre dismantling.
Trollér U, Larsson C
Biochem Biophys Res Commun. 2006
PubMed ID: 16930532
Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS.
Thurnherr T, Benninger Y, Wu X, Chrostek A, Krause SM, Nave KA, Franklin RJ, Brakebusch C, Suter U, Relvas JB
J Neurosci. 2006
PubMed ID: 17021167
Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin.
Wu X, Quondamatteo F, Brakebusch C
Matrix Biol. 2006
PubMed ID: 17049825
The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation.
Gu C, Tangye SG, Sun X, Luo Y, Lin Z, Wu J
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16983070
JNK phosphorylation of paxillin, acting through the Rac1 and Cdc42 signaling cascade, mediates neurite extension in N1E-115 cells.
Yamauchi J, Miyamoto Y, Sanbe A, Tanoue A
Exp Cell Res. 2006
PubMed ID: 16814769
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface.
Cappello S, Attardo A, Wu X, Iwasato T, Itohara S, Wilsch-Bräuninger M, Eilken HM, Rieger MA, Schroeder TT, Huttner WB, Brakebusch C, Götz M
Nat Neurosci. 2006
PubMed ID: 16892058
Binding of Cdc42 to phospholipase D1 is important in neurite outgrowth of neural stem cells.
Yoon MS, Cho CH, Lee KS, Han JS
Biochem Biophys Res Commun. 2006
PubMed ID: 16842757
Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells.
Dejmek J, Säfholm A, Kamp Nielsen C, Andersson T, Leandersson K
Mol Cell Biol. 2006
PubMed ID: 16880514
Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization.
Tskvitaria-Fuller I, Seth A, Mistry N, Gu H, Rosen MK, Wülfing C
J Immunol. 2006
PubMed ID: 16849480
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front.
Van Keymeulen A, Wong K, Knight ZA, Govaerts C, Hahn KM, Shokat KM, Bourne HR
J Cell Biol. 2006
PubMed ID: 16864657
The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity.
Haller C, Rauch S, Michel N, Hannemann S, Lehmann MJ, Keppler OT, Fackler OT
J Biol Chem. 2006
PubMed ID: 16687395
Influencing cellular transformation by modulating the rates of GTP hydrolysis by Cdc42.
Fidyk N, Wang JB, Cerione RA
Biochemistry. 2006
PubMed ID: 16784226
Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin.
Sharma M, Leung L, Brocardo M, Henderson J, Flegg C, Henderson BR
J Biol Chem. 2006
PubMed ID: 16621792
Asymmetric positioning and organization of the meiotic spindle of mouse oocytes requires CDC42 function.
Na J, Zernicka-Goetz M
Curr Biol. 2006
PubMed ID: 16782018
Rac1 links integrin-mediated adhesion to the control of lactational differentiation in mammary epithelia.
Akhtar N, Streuli CH
J Cell Biol. 2006
PubMed ID: 16754961
c-Jun kinase mediates expression of VEGF induced at transcriptional level by Rac1 and Cdc42Hs but not by RhoA.
Saníger ML, Oya R, Macías D, Domínguez JN, Aránega A, Luque F
J Cell Biochem. 2006
PubMed ID: 16440308
The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine nucleotide exchange factor.
Xiang S, Kim EY, Connelly JJ, Nassar N, Kirsch J, Winking J, Schwarz G, Schindelin H
J Mol Biol. 2006
PubMed ID: 16616186
The DNA sequence and biological annotation of human chromosome 1.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E
Nature. 2006
PubMed ID: 16710414
Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix.
Schmidt MH, Husnjak K, Szymkiewicz I, Haglund K, Dikic I
Oncogene. 2006
PubMed ID: 16407834
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter.
Nofer JR, Remaley AT, Feuerborn R, Wolinnska I, Engel T, von Eckardstein A, Assmann G
J Lipid Res. 2006
PubMed ID: 16443932
Activation of Rac-1 and Cdc42 stabilizes the microvascular endothelial barrier.
Waschke J, Burger S, Curry FR, Drenckhahn D, Adamson RH
Histochem Cell Biol. 2006
PubMed ID: 16195887
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.
Wu X, Quondamatteo F, Lefever T, Czuchra A, Meyer H, Chrostek A, Paus R, Langbein L, Brakebusch C
Genes Dev. 2006
PubMed ID: 16510873
Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape.
Fukumoto S, Miner JH, Ida H, Fukumoto E, Yuasa K, Miyazaki H, Hoffman MP, Yamada Y
J Biol Chem. 2006
PubMed ID: 16365040
Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP.
Torres E, Rosen MK
J Biol Chem. 2006
PubMed ID: 16293614
Cdc42 regulates adherens junction stability and endothelial permeability by inducing alpha-catenin interaction with the vascular endothelial cadherin complex.
Broman MT, Kouklis P, Gao X, Ramchandran R, Neamu RF, Minshall RD, Malik AB
Circ Res. 2006
PubMed ID: 16322481
Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility.
Kholmanskikh SS, Koeller HB, Wynshaw-Boris A, Gomez T, Letourneau PC, Ross ME
Nat Neurosci. 2006
PubMed ID: 16369480
Regulation of microtubule dynamics in 3T3 fibroblasts by Rho family GTPases.
Grigoriev I, Borisy G, Vorobjev I
Cell Motil Cytoskeleton. 2006
PubMed ID: 16362953
Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase.
Crocker SJ, Hayley SP, Smith PD, Mount MP, Lamba WR, Callaghan SM, Slack RS, Park DS
J Neurochem. 2006
PubMed ID: 16336220
Role of Cdc42 in neurite outgrowth of PC12 cells and cerebellar granule neurons.
Ahmed I, Calle Y, Iwashita S, Nur-E-Kamal A
Mol Cell Biochem. 2006
PubMed ID: 16328953
Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment.
Wang L, Yang L, Filippi MD, Williams DA, Zheng Y
Blood. 2006
PubMed ID: 16174757
Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3.
Du Y, Böck BC, Schachter KA, Chao M, Gallo KA
J Biol Chem. 2005
PubMed ID: 16253996
Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141.
Jung JH, Traugh JA
J Biol Chem. 2005
PubMed ID: 16204230
Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.
Simmons A, Gangadharan B, Hodges A, Sharrocks K, Prabhakar S, García A, Dwek R, Zitzmann N, McMichael A
Immunity. 2005
PubMed ID: 16356860
The integrin alpha6beta1 modulation of PI3K and Cdc42 activities induces dynamic filopodium formation in human platelets.
Chang JC, Chang HH, Lin CT, Lo SJ
J Biomed Sci. 2005
PubMed ID: 16228294
Leishmania donovani promastigotes induce periphagosomal F-actin accumulation through retention of the GTPase Cdc42.
Lodge R, Descoteaux A
Cell Microbiol. 2005
PubMed ID: 16207251
An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins.
Hemsath L, Dvorsky R, Fiegen D, Carlier MF, Ahmadian MR
Mol Cell. 2005
PubMed ID: 16246732
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
Temporal and spatial transcriptional programs in murine kidney development.
Challen G, Gardiner B, Caruana G, Kostoulias X, Martinez G, Crowe M, Taylor DF, Bertram J, Little M, Grimmond SM
Physiol Genomics. 2005
PubMed ID: 15998744
A Cdc42 mutant specifically activated by intersectin.
Smith WJ, Hamel B, Yohe ME, Sondek J, Cerione RA, Snyder JT
Biochemistry. 2005
PubMed ID: 16201754
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif.
Berzat AC, Buss JE, Chenette EJ, Weinbaum CA, Shutes A, Der CJ, Minden A, Cox AD
J Biol Chem. 2005
PubMed ID: 16046391
Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain.
Ureña JM, La Torre A, Martínez A, Lowenstein E, Franco N, Winsky-Sommerer R, Fontana X, Casaroli-Marano R, Ibáñez-Sabio MA, Pascual M, Del Rio JA, de Lecea L, Soriano E
J Comp Neurol. 2005
PubMed ID: 16052498
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology.
Ryan XP, Alldritt J, Svenningsson P, Allen PB, Wu GY, Nairn AC, Greengard P
Neuron. 2005
PubMed ID: 15996550
RhoGTPase activation is a key step in renal epithelial mesenchymal transdifferentiation.
Patel S, Takagi KI, Suzuki J, Imaizumi A, Kimura T, Mason RM, Kamimura T, Zhang Z
J Am Soc Nephrol. 2005
PubMed ID: 15901767
The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle.
Tang DD, Zhang W, Gunst SJ
J Biol Chem. 2005
PubMed ID: 15834156
Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L.
Wang JB, Wu WJ, Cerione RA
J Biol Chem. 2005
PubMed ID: 15824104
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS
J Cell Sci. 2005
PubMed ID: 15923648
Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis.
Wang G, Beier F
J Bone Miner Res. 2005
PubMed ID: 15883643
Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1.
Phee H, Abraham RT, Weiss A
Nat Immunol. 2005
PubMed ID: 15864311
Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles.
Chen JL, Fucini RV, Lacomis L, Erdjument-Bromage H, Tempst P, Stamnes M
J Cell Biol. 2005
PubMed ID: 15866890
Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells.
Gomes ER, Jani S, Gundersen GG
Cell. 2005
PubMed ID: 15882626
Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.
Aoki K, Nakamura T, Fujikawa K, Matsuda M
Mol Biol Cell. 2005
PubMed ID: 15728722
ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling.
Qian Y, Zhong X, Flynn DC, Zheng JZ, Qiao M, Wu C, Dedhar S, Shi X, Jiang BH
Oncogene. 2005
PubMed ID: 15735674
The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein.
Leung DW, Rosen MK
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15821030
Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes.
Valentijn LJ, Koppen A, van Asperen R, Root HA, Haneveld F, Versteeg R
Cancer Res. 2005
PubMed ID: 15833843
RhoA, RhoB, RhoC, Rac1, Cdc42, and Tc10 mRNA levels in spinal cord, sensory ganglia, and corticospinal tract neurons and long-lasting specific changes following spinal cord injury.
Erschbamer MK, Hofstetter CP, Olson L
J Comp Neurol. 2005
PubMed ID: 15736231
Rho Rocks PTEN.
Meili R, Sasaki AT, Firtel RA
Nat Cell Biol. 2005
PubMed ID: 15803130
Regulation of PTEN by Rho small GTPases.
Li Z, Dong X, Dong X, Wang Z, Liu W, Deng N, Ding Y, Tang L, Hla T, Zeng R, Li L, Wu D
Nat Cell Biol. 2005
PubMed ID: 15793569
Serotonin-induced regulation of the actin network for learning-related synaptic growth requires Cdc42, N-WASP, and PAK in Aplysia sensory neurons.
Udo H, Jin I, Kim JH, Li HL, Youn T, Hawkins RD, Kandel ER, Bailey CH
Neuron. 2005
PubMed ID: 15797550
E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions.
Tunggal JA, Helfrich I, Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R, Krieg T, Niessen CM
EMBO J. 2005
PubMed ID: 15775979
Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway.
Deroanne CF, Hamelryckx D, Ho TT, Lambert CA, Catroux P, Lapière CM, Nusgens BV
J Cell Sci. 2005
PubMed ID: 15728253
Human plasma proteome analysis by multidimensional chromatography prefractionation and linear ion trap mass spectrometry identification.
Jin WH, Dai J, Li SJ, Xia QC, Zou HF, Zeng R
J Proteome Res. 2005
PubMed ID: 15822942
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
Nishimura T, Yamaguchi T, Kato K, Yoshizawa M, Nabeshima Y, Ohno S, Hoshino M, Kaibuchi K
Nat Cell Biol. 2005
PubMed ID: 15723051
Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion.
Wilkinson S, Paterson HF, Marshall CJ
Nat Cell Biol. 2005
PubMed ID: 15723050
Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells.
Parsons M, Monypenny J, Ameer-Beg SM, Millard TH, Machesky LM, Peter M, Keppler MD, Schiavo G, Watson R, Chernoff J, Zicha D, Vojnovic B, Ng T
Mol Cell Biol. 2005
PubMed ID: 15713627
Opposing roles for actin in Cdc42p polarization.
Irazoqui JE, Howell AS, Theesfeld CL, Lew DJ
Mol Biol Cell. 2005
PubMed ID: 15616194
BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain.
Zhou YT, Guy GR, Low BC
Exp Cell Res. 2005
PubMed ID: 15652341
Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes.
Nishikimi A, Meller N, Uekawa N, Isobe K, Schwartz MA, Maruyama M
FEBS Lett. 2005
PubMed ID: 15710388
Involvement of the phosphatidylinositol 3-kinase/rac1 and cdc42 pathways in radial migration of cortical neurons.
Konno D, Yoshimura S, Hori K, Maruoka H, Sobue K
J Biol Chem. 2005
PubMed ID: 15557338
Vav2 as a Rac-GDP/GTP exchange factor responsible for the nectin-induced, c-Src- and Cdc42-mediated activation of Rac.
Kawakatsu T, Ogita H, Fukuhara T, Fukuyama T, Minami Y, Shimizu K, Takai Y
J Biol Chem. 2005
PubMed ID: 15485841
Cdc42 regulates arsenic-induced NADPH oxidase activation and cell migration through actin filament reorganization.
Qian Y, Liu KJ, Chen Y, Flynn DC, Castranova V, Shi X
J Biol Chem. 2005
PubMed ID: 15492012
Cdc42 mediates nucleus movement and MTOC polarization in Swiss 3T3 fibroblasts under mechanical shear stress.
Lee JS, Chang MI, Tseng Y, Wirtz D
Mol Biol Cell. 2005
PubMed ID: 15548602
Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin.
Yamaguchi H, Lorenz M, Kempiak S, Sarmiento C, Coniglio S, Symons M, Segall J, Eddy R, Miki H, Takenawa T, Condeelis J
J Cell Biol. 2005
PubMed ID: 15684033
Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.
Oceguera-Yanez F, Kimura K, Yasuda S, Higashida C, Kitamura T, Hiraoka Y, Haraguchi T, Narumiya S
J Cell Biol. 2005
PubMed ID: 15642749
The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade.
Baird D, Feng Q, Cerione RA
Curr Biol. 2005
PubMed ID: 15649357
Peptide YY and neuropeptide Y induce villin expression, reduce adhesion, and enhance migration in small intestinal cells through the regulation of CD63, matrix metalloproteinase-3, and Cdc42 activity.
Lee M, Hadi M, Halldén G, Aponte GW
J Biol Chem. 2005
PubMed ID: 15504731
Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis.
Fernandez-Zapico ME, Gonzalez-Paz NC, Weiss E, Savoy DN, Molina JR, Fonseca R, Smyrk TC, Chari ST, Urrutia R, Billadeau DD
Cancer Cell. 2005
PubMed ID: 15652748
Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate Sertoli-germ cell adherens junction dynamics in the testis.
Lui WY, Mruk DD, Cheng CY
J Cell Physiol. 2005
PubMed ID: 15389538
NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach.
Kuai J, Wooters J, Hall JP, Rao VR, Nickbarg E, Li B, Chatterjee-Kishore M, Qiu Y, Lin LL
J Biol Chem. 2004
PubMed ID: 15485837
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator.
Grohmanova K, Schlaepfer D, Hess D, Gutierrez P, Beck M, Kroschewski R
J Biol Chem. 2004
PubMed ID: 15355962
Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac.
Birukov KG, Bochkov VN, Birukova AA, Kawkitinarong K, Rios A, Leitner A, Verin AD, Bokoch GM, Leitinger N, Garcia JG
Circ Res. 2004
PubMed ID: 15472119
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.
Reid TS, Terry KL, Casey PJ, Beese LS
J Mol Biol. 2004
PubMed ID: 15451670
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Activation of endogenous Cdc42 visualized in living cells.
Nalbant P, Hodgson L, Kraynov V, Toutchkine A, Hahn KM
Science. 2004
PubMed ID: 15361624
Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology.
Ruusala A, Aspenström P
FEBS Lett. 2004
PubMed ID: 15304341
Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding.
Ng Y, Tan I, Lim L, Leung T
J Biol Chem. 2004
PubMed ID: 15194684
The adaptor protein Nck1 mediates endothelin A receptor-regulated cell migration through the Cdc42-dependent c-Jun N-terminal kinase pathway.
Miyamoto Y, Yamauchi J, Mizuno N, Itoh H
J Biol Chem. 2004
PubMed ID: 15187089
Backbone dynamics of an oncogenic mutant of Cdc42Hs shows increased flexibility at the nucleotide-binding site.
Adams PD, Loh AP, Oswald RE
Biochemistry. 2004
PubMed ID: 15287724
Lipid raft-associated GTPase signaling controls morphology and CD8+ T cell stimulatory capacity of human dendritic cells.
Jaksits S, Bauer W, Kriehuber E, Zeyda M, Stulnig TM, Stingl G, Fiebiger E, Maurer D
J Immunol. 2004
PubMed ID: 15265891
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex.
Ho HY, Rohatgi R, Lebensohn AM, Le Ma, Li J, Gygi SP, Kirschner MW
Cell. 2004
PubMed ID: 15260990
Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42.
Chen XM, Splinter PL, Tietz PS, Huang BQ, Billadeau DD, LaRusso NF
J Biol Chem. 2004
PubMed ID: 15133042
Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments.
Izumi G, Sakisaka T, Baba T, Tanaka S, Morimoto K, Takai Y
J Cell Biol. 2004
PubMed ID: 15263019
Vav GEFs are required for beta2 integrin-dependent functions of neutrophils.
Gakidis MA, Cullere X, Olson T, Wilsbacher JL, Zhang B, Moores SL, Ley K, Swat W, Mayadas T, Brugge JS
J Cell Biol. 2004
PubMed ID: 15249579
Identification of the region in Cdc42 that confers the binding specificity to activated Cdc42-associated kinase.
Gu Y, Lin Q, Childress C, Yang W
J Biol Chem. 2004
PubMed ID: 15123659
Antagonistic cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species.
Diebold BA, Fowler B, Lu J, Dinauer MC, Bokoch GM
J Biol Chem. 2004
PubMed ID: 15123662
Fibroblast growth factor 2 endocytosis in endothelial cells proceed via syndecan-4-dependent activation of Rac1 and a Cdc42-dependent macropinocytic pathway.
Tkachenko E, Lutgens E, Stan RV, Simons M
J Cell Sci. 2004
PubMed ID: 15226395
Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1.
Causeret F, Hidalgo-Sanchez M, Fort P, Backer S, Popoff MR, Gauthier-Rouvière C, Bloch-Gallego E
Development. 2004
PubMed ID: 15151987
Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis.
Sakakibara T, Nemoto Y, Nukiwa T, Takeshima H
FEBS Lett. 2004
PubMed ID: 15147912
Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF/coatomer-dependent actin polymerization on Golgi membranes.
Chen JL, Lacomis L, Erdjument-Bromage H, Tempst P, Stamnes M
FEBS Lett. 2004
PubMed ID: 15147909
Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum.
Chen XM, Huang BQ, Splinter PL, Orth JD, Billadeau DD, McNiven MA, LaRusso NF
Infect Immun. 2004
PubMed ID: 15102814
Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.
Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D
Mol Biol Cell. 2004
PubMed ID: 14978216
Cdc42-dependent mediation of UV-induced p38 activation by G protein betagamma subunits.
Seo M, Cho CH, Lee YI, Shin EY, Park D, Bae CD, Lee JW, Lee ES, Juhnn YS
J Biol Chem. 2004
PubMed ID: 14970210
Cdc42 and mDia3 regulate microtubule attachment to kinetochores.
Yasuda S, Oceguera-Yanez F, Kato T, Okamoto M, Yonemura S, Terada Y, Ishizaki T, Narumiya S
Nature. 2004
PubMed ID: 15085137
Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42.
Edlund S, Landström M, Heldin CH, Aspenström P
J Cell Sci. 2004
PubMed ID: 15075243
DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA.
Mavrakis KJ, McKinlay KJ, Jones P, Sablitzky F
Exp Cell Res. 2004
PubMed ID: 15023524
Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1.
Cheng L, Mahon GM, Kostenko EV, Whitehead IP
J Biol Chem. 2004
PubMed ID: 14701795
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G
J Biol Chem. 2004
PubMed ID: 14676191
Coactivation of Rac1 and Cdc42 at lamellipodia and membrane ruffles induced by epidermal growth factor.
Kurokawa K, Itoh RE, Yoshizaki H, Nakamura YO, Matsuda M
Mol Biol Cell. 2004
PubMed ID: 14699061
Cdc42-dependent nuclear translocation of non-receptor tyrosine kinase, ACK.
Ahmed I, Calle Y, Sayed MA, Kamal JM, Rengaswamy P, Manser E, Meiners S, Nur-E-Kamal A
Biochem Biophys Res Commun. 2004
PubMed ID: 14733946
Cdc42 regulates the restoration of endothelial barrier function.
Kouklis P, Konstantoulaki M, Vogel S, Broman M, Malik AB
Circ Res. 2004
PubMed ID: 14656933
Bioinformatics and cellular signaling.
Papin J, Subramaniam S
Curr Opin Biotechnol. 2004
PubMed ID: 15102471
Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways.
Jaffe AB, Aspenström P, Hall A
Mol Cell Biol. 2004
PubMed ID: 14749388
Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells.
Aoki K, Nakamura T, Matsuda M
J Biol Chem. 2004
PubMed ID: 14570905
Protein profile of tax-associated complexes.
Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F
J Biol Chem. 2004
PubMed ID: 14530271
The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.
Villacé P, Marión RM, Ortín J
Nucleic Acids Res. 2004
PubMed ID: 15121898
Imaging filopodia dynamics in the mouse blastocyst.
Salas-Vidal E, Lomelí H
Dev Biol. 2004
PubMed ID: 14697354
Involvement of Cdc42 signaling in apoA-I-induced cholesterol efflux.
Nofer JR, Feuerborn R, Levkau B, Sokoll A, Seedorf U, Assmann G
J Biol Chem. 2003
PubMed ID: 14563854
Small GTPase Rin induces neurite outgrowth through Rac/Cdc42 and calmodulin in PC12 cells.
Hoshino M, Nakamura S
J Cell Biol. 2003
PubMed ID: 14662747
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1.
Shang X, Zhou YT, Low BC
J Biol Chem. 2003
PubMed ID: 12944407
HIV-1 Nef triggers Vav-mediated signaling pathway leading to functional and morphological differentiation of dendritic cells.
Quaranta MG, Mattioli B, Spadaro F, Straface E, Giordani L, Ramoni C, Malorni W, Viora M
FASEB J. 2003
PubMed ID: 14597672
IQGAP1 promotes cell motility and invasion.
Mataraza JM, Briggs MW, Li Z, Entwistle A, Ridley AJ, Sacks DB
J Biol Chem. 2003
PubMed ID: 12900413
Distinct Rho GTPase activities regulate epithelial cell localization of the adhesion molecule CEACAM1: involvement of the CEACAM1 transmembrane domain.
Fournès B, Farrah J, Olson M, Lamarche-Vane N, Beauchemin N
Mol Cell Biol. 2003
PubMed ID: 14517298
Actin can reorganize into podosomes in aortic endothelial cells, a process controlled by Cdc42 and RhoA.
Moreau V, Tatin F, Varon C, Génot E
Mol Cell Biol. 2003
PubMed ID: 12972601
Activation of Rac2 and Cdc42 on Fc and complement receptor ligation in human neutrophils.
Forsberg M, Druid P, Zheng L, Stendahl O, Särndahl E
J Leukoc Biol. 2003
PubMed ID: 12960248
Differential effects of invasion by and phagocytosis of Salmonella typhimurium on apoptosis in human macrophages: potential role of Rho-GTPases and Akt.
Forsberg M, Blomgran R, Lerm M, Särndahl E, Sebti SM, Hamilton A, Stendahl O, Zheng L
J Leukoc Biol. 2003
PubMed ID: 12960245
Lowe syndrome protein OCRL1 interacts with Rac GTPase in the trans-Golgi network.
Faucherre A, Desbois P, Satre V, Lunardi J, Dorseuil O, Gacon G
Hum Mol Genet. 2003
PubMed ID: 12915445
Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation.
Wu WJ, Tu S, Cerione RA
Cell. 2003
PubMed ID: 14505571
Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.
Labno CM, Lewis CM, You D, Leung DW, Takesono A, Kamberos N, Seth A, Finkelstein LD, Rosen MK, Schwartzberg PL, Burkhardt JK
Curr Biol. 2003
PubMed ID: 13678593
Cdc42 promotes G1 progression through p70 S6 kinase-mediated induction of cyclin E expression.
Chou MM, Masuda-Robens JM, Gupta ML
J Biol Chem. 2003
PubMed ID: 12842876
Identification of an autoinhibitory domain of p21-activated protein kinase 5.
Ching YP, Leong VY, Wong CM, Kung HF
J Biol Chem. 2003
PubMed ID: 12860998
GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2.
Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS
J Biol Chem. 2003
PubMed ID: 12819203
CD28 engagement promotes actin polymerization through the activation of the small Rho GTPase Cdc42 in human T cells.
Salazar-Fontana LI, Barr V, Samelson LE, Bierer BE
J Immunol. 2003
PubMed ID: 12928366
BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.
Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J
Biochem Biophys Res Commun. 2003
PubMed ID: 12901880
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.
Li Z, Hannigan M, Mo Z, Liu B, Lu W, Wu Y, Smrcka AV, Wu G, Li L, Liu M, Huang CK, Wu D
Cell. 2003
PubMed ID: 12887923
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils.
Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, Kelly K, Takuwa Y, Sugimoto N, Mitchison T, Bourne HR
Cell. 2003
PubMed ID: 12887922
Two poles and a compass.
Meili R, Firtel RA
Cell. 2003
PubMed ID: 12887916
RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.
Katoh H, Negishi M
Nature. 2003
PubMed ID: 12879077
p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling.
Nakazawa T, Watabe AM, Tezuka T, Yoshida Y, Yokoyama K, Umemori H, Inoue A, Okabe S, Manabe T, Yamamoto T
Mol Biol Cell. 2003
PubMed ID: 12857875
Nerve growth factor induces proliferation of PC12 cells through Cdc42.
Seo JY, Kim JS, Ghang JH, Kang TC, Suh JG, Kim EG, Kim JI, Kim J, Lee JY, Park JB
Neuroreport. 2003
PubMed ID: 12824775
Cdc42 and RhoA are differentially regulated during arachidonate-mediated HeLa cell adhesion.
Roberts LA, Glenn H, Hahn CS, Jacobson BS
J Cell Physiol. 2003
PubMed ID: 12767056
CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of Cdc42 and Rac activities.
Yanagawa Y, Onoé K
Blood. 2003
PubMed ID: 12609829
TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport.
Chiang SH, Hwang J, Legendre M, Zhang M, Kimura A, Saltiel AR
EMBO J. 2003
PubMed ID: 12773384
Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways.
Zhao D, Kuhnt-Moore S, Zeng H, Wu JS, Moyer MP, Pothoulakis C
Am J Physiol Cell Physiol. 2003
PubMed ID: 12584113
Identification and characterization of the Cdc42-binding site of IQGAP1.
Mataraza JM, Briggs MW, Li Z, Frank R, Sacks DB
Biochem Biophys Res Commun. 2003
PubMed ID: 12745076
Distribution of Rho family GTPases in the adult rat hippocampus and cerebellum.
O'Kane EM, Stone TW, Morris BJ
Brain Res Mol Brain Res. 2003
PubMed ID: 12782387
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation.
Rossman KL, Cheng L, Mahon GM, Rojas RJ, Snyder JT, Whitehead IP, Sondek J
J Biol Chem. 2003
PubMed ID: 12637522
Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis.
Qian Y, Luo J, Leonard SS, Harris GK, Millecchia L, Flynn DC, Shi X
J Biol Chem. 2003
PubMed ID: 12598535
VE-cadherin-induced Cdc42 signaling regulates formation of membrane protrusions in endothelial cells.
Kouklis P, Konstantoulaki M, Malik AB
J Biol Chem. 2003
PubMed ID: 12595527
Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.
Torres E, Rosen MK
Mol Cell. 2003
PubMed ID: 12769846
Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes.
Usui I, Imamura T, Huang J, Satoh H, Olefsky JM
J Biol Chem. 2003
PubMed ID: 12566459
Human neutrophils utilize a Rac/Cdc42-dependent MAPK pathway to direct intracellular granule mobilization toward ingested microbial pathogens.
Zhong B, Jiang K, Gilvary DL, Epling-Burnette PK, Ritchey C, Liu J, Jackson RJ, Hong-Geller E, Wei S
Blood. 2003
PubMed ID: 12511425
A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration.
Guo X, Stafford LJ, Bryan B, Xia C, Ma W, Wu X, Liu D, Songyang Z, Liu M
J Biol Chem. 2003
PubMed ID: 12547822
Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42.
Peng J, Wallar BJ, Flanders A, Swiatek PJ, Alberts AS
Curr Biol. 2003
PubMed ID: 12676083
Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup.
Dombrosky-Ferlan P, Grishin A, Botelho RJ, Sampson M, Wang L, Rudert WA, Grinstein S, Corey SJ
Blood. 2003
PubMed ID: 12456510
ArhGAP15, a novel human RacGAP protein with GTPase binding property.
Seoh ML, Ng CH, Yong J, Lim L, Leung T
FEBS Lett. 2003
PubMed ID: 12650940
RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling.
Okabe T, Nakamura T, Nishimura YN, Kohu K, Ohwada S, Morishita Y, Akiyama T
J Biol Chem. 2003
PubMed ID: 12531901
Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6.
Garrard SM, Capaldo CT, Gao L, Rosen MK, Macara IG, Tomchick DR
EMBO J. 2003
PubMed ID: 12606577
The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.
Masuda-Robens JM, Kutney SN, Qi H, Chou MM
Mol Cell Biol. 2003
PubMed ID: 12612085
Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity.
Etienne-Manneville S, Hall A
Nature. 2003
PubMed ID: 12610628
Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases.
Shao F, Vacratsis PO, Bao Z, Bowers KE, Fierke CA, Dixon JE
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12538863
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Cdc42 and Rac1 are necessary for autotaxin-induced tumor cell motility in A2058 melanoma cells.
Jung ID, Lee J, Yun SY, Park CG, Choi WS, Lee HW, Choi OH, Han JW, Lee HY
FEBS Lett. 2002
PubMed ID: 12482591
Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin.
Vidal C, Geny B, Melle J, Jandrot-Perrus M, Fontenay-Roupie M
Blood. 2002
PubMed ID: 12453877
Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.
Côté JF, Vuori K
J Cell Sci. 2002
PubMed ID: 12432077
RhoG signals in parallel with Rac1 and Cdc42.
Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ
J Biol Chem. 2002
PubMed ID: 12376551
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development.
Natale DR, Watson AJ
Mech Dev. 2002
PubMed ID: 14516655
The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42.
Soltau M, Richter D, Kreienkamp HJ
Mol Cell Neurosci. 2002
PubMed ID: 12504591
Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.
Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N
Mol Cell Biol. 2002
PubMed ID: 12446789
Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.
Cory GO, Garg R, Cramer R, Ridley AJ
J Biol Chem. 2002
PubMed ID: 12235133
Transforming growth factor beta activates Rac1 and Cdc42Hs GTPases and the JNK pathway in skeletal muscle cells.
Meriane M, Charrasse S, Comunale F, Gauthier-Rouvière C
Biol Cell. 2002
PubMed ID: 12566226
Retarded intracellular lipid transport associated with reduced expression of Cdc42, a member of Rho-GTPases, in human aged skin fibroblasts: a possible function of Cdc42 in mediating intracellular lipid transport.
Tsukamoto K, Hirano K, Yamashita S, Sakai N, Ikegami C, Zhang Z, Matsuura F, Hiraoka H, Matsuyama A, Ishigami M, Matsuzawa Y
Arterioscler Thromb Vasc Biol. 2002
PubMed ID: 12426222
Detection of peptides, proteins, and drugs that selectively interact with protein targets.
Serebriiskii IG, Mitina O, Pugacheva EN, Benevolenskaya E, Kotova E, Toby GG, Khazak V, Kaelin WG, Chernoff J, Golemis EA
Genome Res. 2002
PubMed ID: 12421766
Activation of Rac-1, Rac-2, and Cdc42 by hemopoietic growth factors or cross-linking of the B-lymphocyte receptor for antigen.
Grill B, Schrader JW
Blood. 2002
PubMed ID: 12384416
Antiapoptotic Cdc42 mutants are potent activators of cellular transformation.
Tu SS, Wu WJ, Yang W, Nolbant P, Hahn K, Cerione RA
Biochemistry. 2002
PubMed ID: 12369824
Effect of Mg(2+) on the kinetics of guanine nucleotide binding and hydrolysis by Cdc42.
Zhao J, Wang WN, Tan YC, Zheng Y, Wang ZX
Biochem Biophys Res Commun. 2002
PubMed ID: 12270144
N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts.
Charrasse S, Meriane M, Comunale F, Blangy A, Gauthier-Rouvière C
J Cell Biol. 2002
PubMed ID: 12213839
Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins.
Meller N, Irani-Tehrani M, Kiosses WB, Del Pozo MA, Schwartz MA
Nat Cell Biol. 2002
PubMed ID: 12172552
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck.
Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW
Nature. 2002
PubMed ID: 12181570
Pak1 is involved in dendrite initiation as a downstream effector of Rac1 in cortical neurons.
Hayashi K, Ohshima T, Mikoshiba K
Mol Cell Neurosci. 2002
PubMed ID: 12213441
Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.
Luo ZG, Wang Q, Zhou JZ, Wang J, Luo Z, Liu M, He X, Wynshaw-Boris A, Xiong WC, Lu B, Mei L
Neuron. 2002
PubMed ID: 12165471
Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy.
Chockalingam PS, Cholera R, Oak SA, Zheng Y, Jarrett HW, Thomason DB
Am J Physiol Cell Physiol. 2002
PubMed ID: 12107060
IQGAP1 is a component of Cdc42 signaling to the cytoskeleton.
Swart-Mataraza JM, Li Z, Sacks DB
J Biol Chem. 2002
PubMed ID: 11948177
Extension, retraction and contraction in the formation of a dendritic cell dendrite: distinct roles for Rho GTPases.
Swetman CA, Leverrier Y, Garg R, Gan CH, Ridley AJ, Katz DR, Chain BM
Eur J Immunol. 2002
PubMed ID: 12115629
Regulation of cadherin junctions during mouse submandibular gland development.
Menko AS, Zhang L, Schiano F, Kreidberg JA, Kukuruzinska MA
Dev Dyn. 2002
PubMed ID: 12112462
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.
Buchwald G, Friebel A, Galán JE, Hardt WD, Wittinghofer A, Scheffzek K
EMBO J. 2002
PubMed ID: 12093730
Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170.
Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K
Cell. 2002
PubMed ID: 12110184
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J
Nat Struct Biol. 2002
PubMed ID: 12006984
Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain.
Pandey A, Dan I, Kristiansen TZ, Watanabe NM, Voldby J, Kajikawa E, Khosravi-Far R, Blagoev B, Mann M
Oncogene. 2002
PubMed ID: 12032833
Regulation of Cdc42-mediated morphological effects: a novel function for p53.
Gadéa G, Lapasset L, Gauthier-Rouvière C, Roux P
EMBO J. 2002
PubMed ID: 12006490
Participation of small GTPases Rac1 and Cdc42Hs in myoblast transformation.
Meriane M, Charrasse S, Comunale F, Méry A, Fort P, Roux P, Gauthier-Rouvière C
Oncogene. 2002
PubMed ID: 11973651
Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias.
Himmel KL, Bi F, Shen H, Jenkins NA, Copeland NG, Zheng Y, Largaespada DA
J Biol Chem. 2002
PubMed ID: 11839748
The mouse Edr2 (Mph2) gene has two forms of mRNA encoding 90- and 36-kDa polypeptides.
Yamaki M, Isono K, Takada Y, Abe K, Akasaka T, Tanzawa H, Koseki H
Gene. 2002
PubMed ID: 12034499
Rho proteins, mental retardation and the cellular basis of cognition.
Ramakers GJ
Trends Neurosci. 2002
PubMed ID: 11998687
Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation.
Wei L, Imanaka-Yoshida K, Wang L, Zhan S, Schneider MD, DeMayo FJ, Schwartz RJ
Development. 2002
PubMed ID: 11923206
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
Rossman KL, Worthylake DK, Snyder JT, Siderovski DP, Campbell SL, Sondek J
EMBO J. 2002
PubMed ID: 11889037
The Cdc42 and Rac1 GTPases are required for capillary lumen formation in three-dimensional extracellular matrices.
Bayless KJ, Davis GE
J Cell Sci. 2002
PubMed ID: 11884513
The acidic regions of WASp and N-WASP can synergize with CDC42Hs and Rac1 to induce filopodia and lamellipodia.
Hüfner K, Schell B, Aepfelbacher M, Linder S
FEBS Lett. 2002
PubMed ID: 11943145
Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA.
Edlund S, Landström M, Heldin CH, Aspenström P
Mol Biol Cell. 2002
PubMed ID: 11907271
Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression.
Hahn A, Barth H, Kress M, Mertens PR, Goppelt-Struebe M
Biochem J. 2002
PubMed ID: 11829737
Involvement of Rho GTPases and their effectors in the secretory process of PC12 cells.
Frantz C, Coppola T, Regazzi R
Exp Cell Res. 2002
PubMed ID: 11822867
AR and ER interaction with a p21-activated kinase (PAK6).
Lee SR, Ramos SM, Ko A, Masiello D, Swanson KD, Lu ML, Balk SP
Mol Endocrinol. 2002
PubMed ID: 11773441
PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells.
Dan C, Nath N, Liberto M, Minden A
Mol Cell Biol. 2002
PubMed ID: 11756552
Interaction with podocin facilitates nephrin signaling.
Huber TB, Kottgen M, Schilling B, Walz G, Benzing T
J Biol Chem. 2001
PubMed ID: 11562357
Efficient chromosomal mapping of a methylcholanthrene-induced tumor antigen by CTL immunoselection.
Akilesh S, Dudley ME, Eden PA, Roopenian DC
J Immunol. 2001
PubMed ID: 11673526
Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.
Krugmann S, Jordens I, Gevaert K, Driessens M, Vandekerckhove J, Hall A
Curr Biol. 2001
PubMed ID: 11696321
Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.
Wong K, Ren XR, Huang YZ, Xie Y, Liu G, Saito H, Tang H, Wen L, Brady-Kalnay SM, Mei L, Wu JY, Xiong WC, Rao Y
Cell. 2001
PubMed ID: 11672528
RhoGDI-binding-defective mutant of Cdc42Hs targets to membranes and activates filopodia formation but does not cycle with the cytosol of mammalian cells.
Gibson RM, Wilson-Delfosse AL
Biochem J. 2001
PubMed ID: 11583574
Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP.
Hussain NK, Jenna S, Glogauer M, Quinn CC, Wasiak S, Guipponi M, Antonarakis SE, Kay BK, Stossel TP, Lamarche-Vane N, McPherson PS
Nat Cell Biol. 2001
PubMed ID: 11584276
Borg proteins control septin organization and are negatively regulated by Cdc42.
Joberty G, Perlungher RR, Sheffield PJ, Kinoshita M, Noda M, Haystead T, Macara IG
Nat Cell Biol. 2001
PubMed ID: 11584266
Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1.
Richnau N, Aspenström P
J Biol Chem. 2001
PubMed ID: 11431473
Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Piao Y, Ko NT, Lim MK, Ko MS
Genome Res. 2001
PubMed ID: 11544199
Visualization of biochemical networks in living cells.
Remy I, Michnick SW
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11438723
PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family.
Shibata H, Oishi K, Yamagiwa A, Matsumoto M, Mukai H, Ono Y
J Biochem. 2001
PubMed ID: 11432776
Functional analysis of secreted and transmembrane proteins critical to mouse development.
Mitchell KJ, Pinson KI, Kelly OG, Brennan J, Zupicich J, Scherz P, Leighton PA, Goodrich LV, Lu X, Avery BJ, Tate P, Dill K, Pangilinan E, Wakenight P, Tessier-Lavigne M, Skarnes WC
Nat Genet. 2001
PubMed ID: 11431694
Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner.
Kato-Stankiewicz J, Ueda S, Kataoka T, Kaziro Y, Satoh T
Biochem Biophys Res Commun. 2001
PubMed ID: 11394904
Cdc42 is a substrate for caspases and influences Fas-induced apoptosis.
Tu S, Cerione RA
J Biol Chem. 2001
PubMed ID: 11278572
Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter.
Kaminuma O, Deckert M, Elly C, Liu YC, Altman A
Mol Cell Biol. 2001
PubMed ID: 11287617
Interaction of protein kinase C isozymes with Rho GTPases.
Slater SJ, Seiz JL, Stagliano BA, Stubbs CD
Biochemistry. 2001
PubMed ID: 11284700
Loss of alpha3beta1 integrin function results in an altered differentiation program in the mouse submandibular gland.
Menko AS, Kreidberg JA, Ryan TT, Van Bockstaele E, Kukuruzinska MA
Dev Dyn. 2001
PubMed ID: 11307167
Rho and Rac but not Cdc42 regulate endothelial cell permeability.
Wójciak-Stothard B, Potempa S, Eichholtz T, Ridley AJ
J Cell Sci. 2001
PubMed ID: 11257000
Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein.
Ren XR, Du QS, Huang YZ, Ao SZ, Mei L, Xiong WC
J Cell Biol. 2001
PubMed ID: 11238453
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.
Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H
Genes Cells. 2001
PubMed ID: 11260256
PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10.
Neudauer CL, Joberty G, Macara IG
Biochem Biophys Res Commun. 2001
PubMed ID: 11162552
A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes.
Hirsch DS, Pirone DM, Burbelo PD
J Biol Chem. 2001
PubMed ID: 11035016
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.
Miki H, Yamaguchi H, Suetsugu S, Takenawa T
Nature. 2000
PubMed ID: 11130076
The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP.
Low BC, Seow KT, Guy GR
J Biol Chem. 2000
PubMed ID: 10954711
Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42.
Vignal E, De Toledo M, Comunale F, Ladopoulou A, Gauthier-Rouvière C, Blangy A, Fort P
J Biol Chem. 2000
PubMed ID: 10967094
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Structure of the TPR domain of p67phox in complex with Rac.GTP.
Lapouge K, Smith SJ, Walker PA, Gamblin SJ, Smerdon SJ, Rittinger K
Mol Cell. 2000
PubMed ID: 11090627
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Molecular cloning and sequencing of rat Cdc42 GTPase cDNA.
Han JS, Kim JH, Kim JG, Park JB, Noh DY, Lee KH
Exp Mol Med. 2000
PubMed ID: 11048641
The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1.
Johansson A, Driessens M, Aspenström P
J Cell Sci. 2000
PubMed ID: 10954424
Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation.
Zhu K, Debreceni B, Li R, Zheng Y
J Biol Chem. 2000
PubMed ID: 10854437
Developmental control of endocytosis in dendritic cells by Cdc42.
Garrett WS, Chen LM, Kroschewski R, Ebersold M, Turley S, Trombetta S, Galán JE, Mellman I
Cell. 2000
PubMed ID: 10975523
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.
Joberty G, Petersen C, Gao L, Macara IG
Nat Cell Biol. 2000
PubMed ID: 10934474
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
SPECs, small binding proteins for Cdc42.
Pirone DM, Fukuhara S, Gutkind JS, Burbelo PD
J Biol Chem. 2000
PubMed ID: 10816584
GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex.
Carlier MF, Nioche P, Broutin-L'Hermite I, Boujemaa R, Le Clainche C, Egile C, Garbay C, Ducruix A, Sansonetti P, Pantaloni D
J Biol Chem. 2000
PubMed ID: 10781580
Activation of oncogenic pathways in degenerating neurons in Alzheimer disease.
Zhu X, Raina AK, Boux H, Simmons ZL, Takeda A, Smith MA
Int J Dev Neurosci. 2000
PubMed ID: 10817927
Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability.
Chen F, Ma L, Parrini MC, Mao X, Lopez M, Wu C, Marks PW, Davidson L, Kwiatkowski DJ, Kirchhausen T, Orkin SH, Rosen FS, Mayer BJ, Kirschner MW, Alt FW
Curr Biol. 2000
PubMed ID: 10898977
A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation.
Qiu RG, Abo A, Steven Martin G
Curr Biol. 2000
PubMed ID: 10873802
Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress.
Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM
J Biol Chem. 2000
PubMed ID: 10749885
The small GTP-binding protein TC10 promotes nerve elongation in neuronal cells, and its expression is induced during nerve regeneration in rats.
Tanabe K, Tachibana T, Yamashita T, Che YH, Yoneda Y, Ochi T, Tohyama M, Yoshikawa H, Kiyama H
J Neurosci. 2000
PubMed ID: 10818149
Activation of phospholipase D1 by Cdc42 requires the Rho insert region.
Walker SJ, Wu WJ, Cerione RA, Brown HA
J Biol Chem. 2000
PubMed ID: 10747870
Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2.
Low BC, Seow KT, Guy GR
J Biol Chem. 2000
PubMed ID: 10799524
Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation.
Böck BC, Vacratsis PO, Qamirani E, Gallo KA
J Biol Chem. 2000
PubMed ID: 10799501
Structure of Cdc42 bound to the GTPase binding domain of PAK.
Morreale A, Venkatesan M, Mott HR, Owen D, Nietlispach D, Lowe PN, Laue ED
Nat Struct Biol. 2000
PubMed ID: 10802735
Atypical protein kinases Clambda and -zeta associate with the GTP-binding protein Cdc42 and mediate stress fiber loss.
Coghlan MP, Chou MM, Carpenter CL
Mol Cell Biol. 2000
PubMed ID: 10733591
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
p21-activated kinase 1 plays a critical role in cellular activation by Nef.
Fackler OT, Lu X, Frost JA, Geyer M, Jiang B, Luo W, Abo A, Alberts AS, Peterlin BM
Mol Cell Biol. 2000
PubMed ID: 10713183
Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules.
Tian L, Nelson DL, Stewart DM
J Biol Chem. 2000
PubMed ID: 10713100
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.
Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK
Nature. 2000
PubMed ID: 10724160
Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA.
Prakash SK, Paylor R, Jenna S, Lamarche-Vane N, Armstrong DL, Xu B, Mancini MA, Zoghbi HY
Hum Mol Genet. 2000
PubMed ID: 10699171
Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI.
Hoffman GR, Nassar N, Cerione RA
Cell. 2000
PubMed ID: 10676816
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
Eisenmann KM, McCarthy JB, Simpson MA, Keely PJ, Guan JL, Tachibana K, Lim L, Manser E, Furcht LT, Iida J
Nat Cell Biol. 1999
PubMed ID: 10587647
Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42.
Low BC, Lim YP, Lim J, Wong ES, Guy GR
J Biol Chem. 1999
PubMed ID: 10551883
The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins.
Joberty G, Perlungher RR, Macara IG
Mol Cell Biol. 1999
PubMed ID: 10490598
The human CDC42 gene: genomic organization, evidence for the existence of a putative pseudogene and exclusion as a SJS1 candidate gene.
Nicole S, White PS, Topaloglu H, Beigthon P, Salih M, Hentati F, Fontaine B
Hum Genet. 1999
PubMed ID: 10480361
Activation of Ste20 by Nef from human immunodeficiency virus induces cytoskeletal rearrangements and downstream effector functions in Saccharomyces cerevisiae.
Plemenitas A, Lu X, Geyer M, Veranic P, Simon MN, Peterlin BM
Virology. 1999
PubMed ID: 10366564
Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK.
Mott HR, Owen D, Nietlispach D, Lowe PN, Manser E, Lim L, Laue ED
Nature. 1999
PubMed ID: 10360579
Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein.
Abdul-Manan N, Aghazadeh B, Liu GA, Majumdar A, Ouerfelli O, Siminovitch KA, Rosen MK
Nature. 1999
PubMed ID: 10360578
Conformation of a Cdc42/Rac interactive binding peptide in complex with Cdc42 and analysis of the binding interface.
Stevens WK, Vranken W, Goudreau N, Xiang H, Xu P, Ni F
Biochemistry. 1999
PubMed ID: 10320322
The mouse Rhl1 and Rhag genes: sequence, organization, expression, and chromosomal mapping.
Liu Z, Huang CH
Biochem Genet. 1999
PubMed ID: 10495887
Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal.
Rudolph MG, Wittinghofer A, Vetter IR
Protein Sci. 1999
PubMed ID: 10211824
Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway.
Baba Y, Nonoyama S, Matsushita M, Yamadori T, Hashimoto S, Imai K, Arai S, Kunikata T, Kurimoto M, Kurosaki T, Ochs HD, Yata J, Kishimoto T, Tsukada S
Blood. 1999
PubMed ID: 10068673
The small GTPase RalA targets filamin to induce filopodia.
Ohta Y, Suzuki N, Nakamura S, Hartwig JH, Stossel TP
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10051605
A role for Rho-like GTPases in the polarisation of mouse eight-cell blastomeres.
Clayton L, Hall A, Johnson MH
Dev Biol. 1999
PubMed ID: 9917367
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42.
Ma L, Rohatgi R, Kirschner MW
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9860974
Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP.
Nassar N, Hoffman GR, Manor D, Clardy JC, Cerione RA
Nat Struct Biol. 1998
PubMed ID: 9846874
Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.
Peters LL, Weier HU, Walensky LD, Snyder SH, Parra M, Mohandas N, Conboy JG
Genomics. 1998
PubMed ID: 9828140
PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia.
Abo A, Qu J, Cammarano MS, Dan C, Fritsch A, Baud V, Belisle B, Minden A
EMBO J. 1998
PubMed ID: 9822598
Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1.
Illenberger D, Schwald F, Pimmer D, Binder W, Maier G, Dietrich A, Gierschik P
EMBO J. 1998
PubMed ID: 9799233
Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Ko MS, Threat TA, Wang X, Horton JH, Cui Y, Wang X, Pryor E, Paris J, Wells-Smith J, Kitchen JR, Rowe LB, Eppig J, Satoh T, Brant L, Fujiwara H, Yotsumoto S, Nakashima H
Hum Mol Genet. 1998
PubMed ID: 9811942
CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac.
Lamarche-Vane N, Hall A
J Biol Chem. 1998
PubMed ID: 9786927
Identification of the binding surface on Cdc42Hs for p21-activated kinase.
Guo W, Sutcliffe MJ, Cerione RA, Oswald RE
Biochemistry. 1998
PubMed ID: 9760238
Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation.
Zhang B, Zheng Y
J Biol Chem. 1998
PubMed ID: 9748241
Tyrosine phosphorylation of the Wiskott-Aldrich syndrome protein by Lyn and Btk is regulated by CDC42.
Guinamard R, Aspenström P, Fougereau M, Chavrier P, Guillemot JC
FEBS Lett. 1998
PubMed ID: 9742969
Structural requirements for PAK activation by Rac GTPases.
Knaus UG, Wang Y, Reilly AM, Warnock D, Jackson JH
J Biol Chem. 1998
PubMed ID: 9705280
The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation.
Rudolph MG, Bayer P, Abo A, Kuhlmann J, Vetter IR, Wittinghofer A
J Biol Chem. 1998
PubMed ID: 9660763
Phagocyte NADPH oxidase p67-phox possesses a novel carboxylterminal binding site for the GTPases Rac2 and Cdc42.
Faris SL, Rinckel LA, Huang J, Hong YR, Kleinberg ME
Biochem Biophys Res Commun. 1998
PubMed ID: 9642115
A role for Cdc42 in macrophage chemotaxis.
Allen WE, Zicha D, Ridley AJ, Jones GE
J Cell Biol. 1998
PubMed ID: 9606207
Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation.
Billuart P, Bienvenu T, Ronce N, des Portes V, Vinet MC, Zemni R, Roest Crollius H, Carrié A, Fauchereau F, Cherry M, Briault S, Hamel B, Fryns JP, Beldjord C, Kahn A, Moraine C, Chelly J
Nature. 1998
PubMed ID: 9582072
Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA.
Zhang B, Chernoff J, Zheng Y
J Biol Chem. 1998
PubMed ID: 9535855
Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7.
Alberts AS, Bouquin N, Johnston LH, Treisman R
J Biol Chem. 1998
PubMed ID: 9535835
The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes.
Auer KL, Contessa J, Brenz-Verca S, Pirola L, Rusconi S, Cooper G, Abo A, Wymann MP, Davis RJ, Birrer M, Dent P
Mol Biol Cell. 1998
PubMed ID: 9487126
Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity.
Gorvel JP, Chang TC, Boretto J, Azuma T, Chavrier P
FEBS Lett. 1998
PubMed ID: 9490022
Rho GTPases and the actin cytoskeleton.
Hall A
Science. 1998
PubMed ID: 9438836
The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3.
Nagata K, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A
EMBO J. 1998
PubMed ID: 9427749
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP.
Miki H, Sasaki T, Takai Y, Takenawa T
Nature. 1998
PubMed ID: 9422512
Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.
Leung T, Chen XQ, Tan I, Manser E, Lim L
Mol Cell Biol. 1998
PubMed ID: 9418861
Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190.
Li R, Zhang B, Zheng Y
J Biol Chem. 1997
PubMed ID: 9407060
Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue.
Rittinger K, Walker PA, Eccleston JF, Smerdon SJ, Gamblin SJ
Nature. 1997
PubMed ID: 9338791
Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains.
Zhang B, Wang ZX, Zheng Y
J Biol Chem. 1997
PubMed ID: 9268338
MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42.
Fanger GR, Johnson NL, Johnson GL
EMBO J. 1997
PubMed ID: 9305638
Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.
Rittinger K, Walker PA, Eccleston JF, Nurmahomed K, Owen D, Laue E, Gamblin SJ, Smerdon SJ
Nature. 1997
PubMed ID: 9262406
Definition of the switch surface in the solution structure of Cdc42Hs.
Feltham JL, Dötsch V, Raza S, Manor D, Cerione RA, Sutcliffe MJ, Wagner G, Oswald RE
Biochemistry. 1997
PubMed ID: 9220962
A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton.
Aspenström P
Curr Biol. 1997
PubMed ID: 9210375
Complete cDNAs for CDC42 from chicken cochlea and mouse liver.
Gong TW, Shin JJ, Burmeister M, Lomax MI
Biochim Biophys Acta. 1997
PubMed ID: 9224952
Calmodulin modulates the interaction between IQGAP1 and Cdc42. Identification of IQGAP1 by nanoelectrospray tandem mass spectrometry.
Joyal JL, Annan RS, Ho YD, Huddleston ME, Carr SA, Hart MJ, Sacks DB
J Biol Chem. 1997
PubMed ID: 9182573
RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas.
Adra CN, Manor D, Ko JL, Zhu S, Horiuchi T, Van Aelst L, Cerione RA, Lim B
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9113980
Bni1p, a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesis.
Evangelista M, Blundell K, Longtine MS, Chow CJ, Adames N, Pringle JR, Peter M, Boone C
Science. 1997
PubMed ID: 9082982
Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway.
Gerwins P, Blank JL, Johnson GL
J Biol Chem. 1997
PubMed ID: 9079650
Lck regulates Vav activation of members of the Rho family of GTPases.
Han J, Das B, Wei W, Van Aelst L, Mosteller RD, Khosravi-Far R, Westwick JK, Der CJ, Broek D
Mol Cell Biol. 1997
PubMed ID: 9032261
Signal transduction pathways involving the small G proteins rac and Cdc42 and phosphoinositide kinases.
Carpenter CL, Tolias KF, Couvillon AC, Hartwig JH
Adv Enzyme Regul. 1997
PubMed ID: 9381982
The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine-nucleotide exchange factor.
Zheng Y, Fischer DJ, Santos MF, Tigyi G, Pasteris NG, Gorski JL, Xu Y
J Biol Chem. 1996
PubMed ID: 8969170
CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1.
Lu X, Wu X, Plemenitas A, Yu H, Sawai ET, Abo A, Peterlin BM
Curr Biol. 1996
PubMed ID: 8994833
The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog.
Gilbreth M, Yang P, Wang D, Frost J, Polverino A, Cobb MH, Marcus S
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8943016
Genomic organization and chromosomal location of murine Cdc42.
Marks PW, Kwiatkowski DJ
Genomics. 1996
PubMed ID: 8954774
Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family.
Teramoto H, Coso OA, Miyata H, Igishi T, Miki T, Gutkind JS
J Biol Chem. 1996
PubMed ID: 8910292
Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1.
Kuroda S, Fukata M, Kobayashi K, Nakafuku M, Nomura N, Iwamatsu A, Kaibuchi K
J Biol Chem. 1996
PubMed ID: 8798539
Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2.
McCallum SJ, Wu WJ, Cerione RA
J Biol Chem. 1996
PubMed ID: 8702968
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases.
Brill S, Li S, Lyman CW, Church DM, Wasmuth JJ, Weissbach L, Bernards A, Snijders AJ
Mol Cell Biol. 1996
PubMed ID: 8756646
Identification of genes expressed after noise exposure in the chick basilar papilla.
Gong TW, Hegeman AD, Shin JJ, Adler HJ, Raphael Y, Lomax MI
Hear Res. 1996
PubMed ID: 8817303
IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs.
Hart MJ, Callow MG, Souza B, Polakis P
EMBO J. 1996
PubMed ID: 8670801
Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42.
Kolluri R, Tolias KF, Carpenter CL, Rosen FS, Kirchhausen T
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8643625
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization.
Symons M, Derry JM, Karlak B, Jiang S, Lemahieu V, Mccormick F, Francke U, Abo A
Cell. 1996
PubMed ID: 8625410
A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases.
Burbelo PD, Drechsel D, Hall A
J Biol Chem. 1995
PubMed ID: 7493928
Binding of prenylated and polybasic peptides to membranes: affinities and intervesicle exchange.
Ghomashchi F, Zhang X, Liu L, Gelb MH
Biochemistry. 1995
PubMed ID: 7547927
Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families.
Barron-Casella EA, Torres MA, Scherer SW, Heng HH, Tsui LC, Casella JF
J Biol Chem. 1995
PubMed ID: 7665558
Rho family GTPases bind to phosphoinositide kinases.
Tolias KF, Cantley LC, Carpenter CL
J Biol Chem. 1995
PubMed ID: 7629060
A 68-kDa kinase and NADPH oxidase component p67phox are targets for Cdc42Hs and Rac1 in neutrophils.
Prigmore E, Ahmed S, Best A, Kozma R, Manser E, Segal AW, Lim L
J Biol Chem. 1995
PubMed ID: 7738010
A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.
Martin GA, Bollag G, McCormick F, Abo A
EMBO J. 1995
PubMed ID: 7744004
Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.
Zheng Y, Bagrodia S, Cerione RA
J Biol Chem. 1994
PubMed ID: 8034624
Cloning and characterization of a novel RNA involved in cellular growth regulation.
Moats-Staats BM, Jarvis HW, D'Ercole AJ, Stiles AD
Mol Cell Biol. 1994
PubMed ID: 7513047
A brain serine/threonine protein kinase activated by Cdc42 and Rac1.
Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L
Nature. 1994
PubMed ID: 8107774
Small GTP-binding proteins and the regulation of the actin cytoskeleton.
Hall A
Annu Rev Cell Biol. 1994
PubMed ID: 7888179
Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse.
Warden CH, Mehrabian M, He KY, Yoon MY, Diep A, Xia YR, Wen PZ, Svenson KL, Sparkes RS, Lusis AJ
Genomics. 1993
PubMed ID: 8288233
Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins.
Kwong CH, Malech HL, Rotrosen D, Leto TL
Biochemistry. 1993
PubMed ID: 8504089
Oncogene ect2 is related to regulators of small GTP-binding proteins.
Miki T, Smith CL, Long JE, Eva A, Fleming TP
Nature. 1993
PubMed ID: 8464478
The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach.
Chavrier P, Simons K, Zerial M
Gene. 1992
PubMed ID: 1555775
Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product.
Hart MJ, Eva A, Evans T, Aaronson SA, Cerione RA
Nature. 1991
PubMed ID: 1956381
Membrane-binding domain of the small G protein G25K contains an S-(all-trans-geranylgeranyl)cysteine methyl ester at its carboxyl terminus.
Yamane HK, Farnsworth CC, Xie HY, Evans T, Howald WN, Gelb MH, Glomset JA, Clarke S, Fung BK
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1898776
Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42.
Shinjo K, Koland JG, Hart MJ, Narasimhan V, Johnson DI, Evans T, Cerione RA
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2124704
Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42.
Munemitsu S, Innis MA, Clark R, McCormick F, Ullrich A, Polakis P
Mol Cell Biol. 1990
PubMed ID: 2122236
Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain.
Polakis PG, Snyderman R, Evans T
Biochem Biophys Res Commun. 1989
PubMed ID: 2496687
Ultrastructural observations on stumpy (stm), a new chondrodystrophic mutant in the mouse.
Johnson DR
J Embryol Exp Morphol. 1977
PubMed ID: 886261

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	998	12540	64465
EnsEMBL Gene(s)	ENSG00000070831	ENSMUSG00000006699	ENSRNOG00000013536
Unigene	Hs.467637	Mm.1022	Rn.228625
Homologene	CDC42	Cdc42	Cdc42
OMIM	116952	N/A	N/A
GeneCards	CDC42	N/A	N/A
Beta Cell Genomics	DT.100038646 DT.100657929 DT.100845422 DT.454483 DT.92457158 DT.92457170 DT.95172215 DT.95172226 DT.97860521 DT.99994472	DT.101406050 DT.101406058 DT.102536792 DT.103573115 DT.110837031 DT.91299918 DT.91331180 DT.94388540 DT.94388615 DT.94388621 DT.97374782	N/A
Reactome	P60953	N/A	N/A
Plasma Peptide Atlas	ENSP00000238738	N/A	N/A
WikiGenes	998	12540	64465

External resources from NIDDK Consortium Interconnectivity Network Top Help

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Interactor	Interactor	Sources	Classification	Pubmed IDs
CDC42	MUC12	IntAct, BioGRID	empirical	20936779
CDC42	ACTR3	HPRD	empirical	9860974
CDC42	WASF2	HPRD	empirical	12181570
CDC42	TNK2	HPRD, IntAct, BioGRID	empirical	11394904 10802735 20936779 10360579 20086093
CDC42	CDKN1A	BioGRID	empirical	18057010
CDC42	NET1	BioGRID	empirical	9535835
CDC42	PAK4	HPRD, IntAct, BioGRID	empirical	9822598 17353931 20936779 11756552
CDC42	CDC42EP2	HPRD, IntAct, BioGRID	empirical	11035016 20936779 21988832 10490598
CDC42	BAIAP2	HPRD, IntAct, BioGRID	empirical	11696321 20936779 12504591 11130076
CDC42	KAT5	HPRD, MINT, IntAct, BioGRID	empirical	16169070
CDC42	CDC42EP3	HPRD, IntAct, BioGRID	empirical	10490598 20936779 9535835
CDC42	ZNF234	IntAct, BioGRID	empirical	18624398
CDC42	IQGAP2	HPRD, MINT, BioGRID	empirical	8756646 8702968 17254974
CDC42	CFHR4	IntAct, BioGRID	empirical	18624398
CDC42	METAP2	HPRD	empirical	7738010
CDC42	RAB35	MINT	empirical	19289122
CDC42	CDC42EP1	HPRD, MINT, IntAct, BioGRID	empirical	16189514 20936779 21988832
CDC42	C14orf1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
CDC42	FMNL2	IntAct, BioGRID	empirical	20936779
CDC42	ARHGEF25	HPRD, BioGRID	empirical	12547822
CDC42	SSX2IP	IntAct	empirical	21988832
CDC42	CPN1	IntAct, BioGRID	empirical	18624398
CDC42	DOCK11	Reactome	predicted	15710388 17027967 15247287 17196961 12134158
CDC42	CSN2	IntAct, BioGRID	empirical	20936779
CDC42	CSPG4	HPRD, BioGRID	empirical	10587647
CDC42	CDC42EP5	HPRD, BioGRID	empirical	10490598 11035016 11584266
CDC42	BNIPL	BioGRID	empirical	12901880
CDC42	SH3D19	IntAct	empirical	20936779
CDC42	KIAA2026	BioGRID	empirical	20936779
CDC42	DIAPH2	IntAct, BioGRID	empirical	20936779
CDC42	DOCK1	Reactome	predicted	15710388 17027967 15247287 17196961 12134158
CDC42	ABCA1	BioGRID	empirical	16443932
CDC42	EEF1G	HPRD, MINT, IntAct, BioGRID	empirical	16169070
CDC42	AHSG	IntAct, BioGRID	empirical	18624398
CDC42	UBR1	HPRD, MINT, IntAct	empirical	16169070
CDC42	A2M	IntAct, BioGRID	empirical	18624398
CDC42	ARHGAP27	BioGRID	empirical	15147912
CDC42	ETFA	IntAct	empirical	18624398
CDC42	FGD1	HPRD, BioGRID	empirical	8969170
CDC42	KIN	BioGRID	empirical	9535835
CDC42	DAAM1	MINT	empirical	16630611
CDC42	FNBP1	HPRD	empirical	12421766
CDC42	ARHGAP26	BioGRID	empirical	11432776
CDC42	FLNA	HPRD	empirical	10051605
CDC42	MCF2L	HPRD, IntAct, BioGRID	empirical	11889037 12006984 14701795
CDC42	SYNE1	IntAct, BioGRID	empirical	20936779
CDC42	DOCK9	HPRD, BioGRID, Reactome	empirical	12172552 15710388 17027967 15247287 17196961 12134158
CDC42	FNTA	IntAct	empirical	15451670
CDC42	SCRIB	IntAct	empirical	18329370
CDC42	CDC42EP4	IntAct, BioGRID	empirical	20936779
CDC42	NGEF	MINT	empirical	18256687
CDC42	GDI1	HPRD, BioGRID	empirical	11583574
CDC42	GRB2	BioGRID	empirical	21900206
CDC42	ANXA2	HPRD	empirical	17254974
CDC42	APOH	IntAct, BioGRID	empirical	18624398
CDC42	KTN1	HPRD	empirical	9535835
CDC42	ARHGAP1	HPRD, IntAct, BioGRID	empirical	9268338 9846874 9262406 9338791 9427749 9407060 10551883 9535855
CDC42	LCK	HPRD, IntAct	empirical	16293614
CDC42	LGALS1	IntAct, BioGRID	empirical	18624398
CDC42	ARHGDIA	HPRD, IntAct, BioGRID	empirical	10676816 11149925 17353931 20936779 9490022 21900206
CDC42	ARHGDIB	HPRD	empirical	9799233
CDC42	ARHGDIG	HPRD, BioGRID	empirical	9113980
CDC42	SH2D1A	MINT	empirical	16983070
CDC42	ARRB1	IntAct, BioGRID	empirical	20936779
CDC42	ARRB2	IntAct, BioGRID	empirical	20936779
CDC42	MCF2	BioGRID	empirical	10854437
CDC42	MAP3K4	HPRD, BioGRID	empirical	9079650
CDC42	MAP3K10	HPRD, BioGRID	empirical	9427749
CDC42	MAP3K11	HPRD, IntAct, BioGRID	empirical	10799501 16253996 20890305 9427749
CDC42	COX1	BioGRID	empirical	20936779
CDC42	MYO6	IntAct, BioGRID	empirical	20936779
CDC42	MYO9A	HPRD, MINT, IntAct, BioGRID	empirical	16169070 20936779
CDC42	NCF2	HPRD, MINT, IntAct, BioGRID	empirical	9642115 7738010 11090627
CDC42	NPHS1	BioGRID	empirical	11562357
CDC42	OCRL	HPRD	empirical	12915445
CDC42	OPHN1	HPRD, BioGRID	empirical	11998687 9582072
CDC42	PAK1	HPRD, MINT, IntAct, BioGRID	empirical	9705280 7744004 8107774 10802735 12123608 18325335 19596003 18854161 21029865 20936779 12879077 7493928 12606577 15102471 9418861 12650940 9535855 12165471
CDC42	DEF6	HPRD, BioGRID	empirical	15023524
CDC42	PAK2	HPRD, IntAct, BioGRID	empirical	10320322 16204230 17353931 20936779 9822598 9535855
CDC42	PAK3	IntAct	empirical	20936779 7493928
CDC42	PARD6A	HPRD, IntAct, BioGRID	empirical	10873802 12606577 14676191 11260256 10934474
CDC42	PDE6D	HPRD, MINT, IntAct, BioGRID	empirical	16169070
CDC42	PGGT1B	HPRD	empirical	15451670
CDC42	PIK3R1	HPRD, MINT	empirical	9381982 7629060 8034624 17024187
CDC42	PLD1	HPRD, BioGRID	empirical	10747870
CDC42	ERRFI1	HPRD, BioGRID	empirical	10749885
CDC42	FNBP1L	BioGRID	empirical	15260990
CDC42	ARHGAP17	BioGRID	empirical	11431473
CDC42	RIF1	IntAct	empirical	16169070
CDC42	PPP2R2B	IntAct	empirical	19156129
CDC42	CDC42BPG	HPRD, IntAct, BioGRID	empirical	15194684
CDC42	PRKCA	HPRD	empirical	11284700
CDC42	LRIF1	HPRD, MINT	empirical	16169070
CDC42	PRKCG	HPRD	empirical	14676191
CDC42	PRKCI	HPRD, IntAct	empirical	10934474 14676191 11260256
CDC42	PRKCZ	HPRD	empirical	10733591
CDC42	EIF2AK2	HPRD, MINT	empirical	7738010
CDC42	PARD3	HPRD, IntAct	empirical	10934474
CDC42	CDC42SE1	HPRD, IntAct, BioGRID	empirical	10816584 12421766 20936779
CDC42	PAK6	HPRD, IntAct, BioGRID	empirical	11773441 20936779
CDC42	CDC42SE2	BioGRID	empirical	10816584
CDC42	GOPC	BioGRID	empirical	11162552
CDC42	PAK7	HPRD, IntAct, BioGRID	empirical	12032833 11756552 20936779
CDC42	RHOJ	HPRD	empirical	10967094
CDC42	ARHGAP31	HPRD	empirical	9786927
CDC42	SRGAP1	HPRD	empirical	11672528
CDC42	DOCK6	Reactome	predicted	15710388 17027967 15247287 17196961 12134158
CDC42	PTPN2	IntAct	empirical	16293614
CDC42	MARK4	HPRD, IntAct, BioGRID	empirical	14676191
CDC42	RAC1	MINT, IntAct, BioGRID	empirical	15102471 9427749
CDC42	RAC2	HPRD	empirical	9748241
CDC42	RAP1GDS1	IntAct, BioGRID	empirical	20936779
CDC42	ROCK1	BioGRID	empirical	9535835
CDC42	BCR	BioGRID	empirical	9535855
CDC42	RPL22	IntAct, BioGRID	empirical	20936779
CDC42	RPS6KB1	HPRD, MINT	empirical	11438723
CDC42	CLIP1	BioGRID	empirical	12110184
CDC42	S100A9	IntAct	empirical	20936779
CDC42	ITSN1	HPRD, IntAct, BioGRID	empirical	12006984 11584276 15824104
CDC42	PLEKHG2	HPRD, BioGRID	empirical	11839748
CDC42	BNIP2	HPRD, BioGRID	empirical	10954711 10799524 10551883
CDC42	ST13	IntAct, BioGRID	empirical	20936779
CDC42	STAU1	HPRD, IntAct	empirical	15121898
CDC42	VAMP2	IntAct	empirical	15537656
CDC42	TNF	BioGRID	empirical	15485837
CDC42	TP53	HPRD, MINT, IntAct, BioGRID	empirical	16169070
CDC42	TRAF6	IntAct	empirical	17353931
CDC42	UBC	IntAct, BioGRID	empirical	20936779 21139048 21906983
CDC42	VAV1	HPRD, MINT, BioGRID	empirical	11287617 18511940
CDC42	VRK2	IntAct, BioGRID	empirical	20936779
CDC42	WAS	HPRD, MINT, IntAct, BioGRID	empirical	8625410 10724160 15361624 12235133 10068673 12769846 9742969 10360578 10802735 20936779 9660763 10713100 8643625
CDC42	ZNF175	IntAct, BioGRID	empirical	20936779
CDC42	ARHGAP10	BioGRID	empirical	11432776
CDC42	CBLL1	BioGRID	empirical	18057010
CDC42	DIAPH3	BioGRID	empirical	9535835
CDC42	DOCK8	HPRD, BioGRID, Reactome	empirical	15304341 15710388 17027967 15247287 17196961 12134158
CDC42	ARHGAP24	IntAct	empirical	16862148
CDC42	CASP3	HPRD	empirical	11278572
CDC42	CASP7	HPRD	empirical	11278572
CDC42	TBC1D3F	HPRD	empirical	12612085
CDC42	PARD6G	HPRD, IntAct, BioGRID	empirical	11260256 14676191
CDC42	PARD6B	HPRD, IntAct, BioGRID	empirical	14676191 11260256 10934474 20936779 12606577 11162552
CDC42	CDC42BPA	IntAct, BioGRID	empirical	20936779 15194684 9418861
CDC42	CNTNAP1	BioGRID	empirical	9535855
CDC42	DOCK7	HPRD	empirical	12432077
CDC42	CBL	BioGRID	empirical	14505571 16356860
CDC42	RIOK3	IntAct	empirical	21988832
CDC42	IQGAP1	HPRD, MINT, IntAct, BioGRID	empirical	12900413 8670801 8798539 9182573 8702968 8756646 12745076 12110184 9535855
CDC42	ARHGEF7	HPRD, MINT, BioGRID	empirical	15649357 16983070 14505571
CDC42	MCM3AP	IntAct, BioGRID	empirical	20936779
CDC42	HERC2	IntAct, BioGRID	empirical	20936779
CDC42	WASF1	HPRD	empirical	12181570 15834156
CDC42	WASL	HPRD, MINT, IntAct, BioGRID	empirical	10724160 9422512 11943145 15834156 20936779 16293614 10781580
CDC42	DNAJA3	IntAct	empirical	18624398
CDC42	UNC119	HPRD, MINT, IntAct, BioGRID	empirical	16169070
CDC42	TRIP10	HPRD, MINT, BioGRID	empirical	12456510 10713100 9210375
CDC42	RPL23	IntAct, BioGRID	empirical	20936779
CDC42	ARHGAP29	BioGRID	empirical	14749388
CDC42	ARHGEF6	HPRD	empirical	15649357
CDC42	BCAR1	MINT	empirical	17038317
CDC42	CDC42BPB	IntAct, BioGRID	empirical	20936779 9418861
CDC42	ARHGAP32	IntAct, BioGRID	empirical	20936779 12857875 12819203 12531901 12446789
CDC42	ARHGEF11	IntAct, BioGRID	empirical	20936779
CDC42	ARHGAP44	BioGRID	empirical	11431473
CDC42	CDC42	BioGRID	empirical	10211824
CDC42	CDH1	BioGRID	empirical	18057010