CDC25A

Summary Top Help

Gene Description:

cell division cycle 25 homolog A (S. pombe)

Synonyms:

Cdc25a, CDC25A2, CDC25A, D9Ertd393e

Orthologs:

Human CDC25A (protein-coding), Mouse Cdc25a (protein-coding), Rat Cdc25a (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr3:48198636..48229892 (31.26 kb) View in Genome Browser

(Mouse) NCBIM37 - chr9:109778083..109796394 (18.31 kb) View in Genome Browser

(Rat) RGSC3.4 - chr8:114237704..114255971 (18.27 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CDC25A:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CDC25A:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 2

Biocarta: 7

Reactome: 20

NCI-Nature Pathway Interaction Database: 4

Gene Ontology: 21

Publications from PubMed Top Help

Publications: 172

A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors.
Myer DL, Robbins SB, Yin M, Boivin GP, Liu Y, Greis KD, Bahassi el M, Stambrook PJ
Mutat Res. 2011
PubMed ID: 21376736
Cdc25A regulates matrix metalloprotease 1 through Foxo1 and mediates metastasis of breast cancer cells.
Feng X, Wu Z, Wu Y, Hankey W, Prior TW, Li L, Ganju RK, Shen R, Zou X
Mol Cell Biol. 2011
PubMed ID: 21670150
High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A.
Vijayakumar S, Liu G, Rus IA, Yao S, Chen Y, Akiri G, Grumolato L, Aaronson SA
Cancer Cell. 2011
PubMed ID: 21575861
CDC25A, VAV1, TP73, BRCA1 and ZAP70 gene overexpression correlates with radiation response in colorectal cancer.
Huang MY, Wang JY, Chang HJ, Kuo CW, Tok TS, Lin SR
Oncol Rep. 2011
PubMed ID: 21344162
Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells.
Lee G, Origanti S, White LS, Sun J, Stappenbeck TS, Piwnica-Worms H
PLoS One. 2011
PubMed ID: 21283624
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Human Cdc14A phosphatase modulates the G2/M transition through Cdc25A and Cdc25B.
Vázquez-Novelle MD, Mailand N, Ovejero S, Bueno A, Sacristán MP
J Biol Chem. 2010
PubMed ID: 20956543
Cdc25A-driven proliferation regulates CD62L levels and lymphocyte movement in response to interleukin-7.
Kittipatarin C, Li W, Durum SK, Khaled AR
Exp Hematol. 2010
PubMed ID: 20831893
CDC 25A gene 263C/T, -350C/T, and -51C/G polymorphisms in breast carcinoma.
Karagoz ID, Ozaslan M, Cengiz B, Kalender ME, Kilic IH, Oztuzcu S, Gogebakan B, Demiryurek AT
Tumour Biol. 2010
PubMed ID: 20614206
A role for the cell cycle phosphatase Cdc25a in vitamin D-dependent inhibition of adult rat vascular smooth muscle cell proliferation.
Chen S, Law CS, Grigsby CL, Olsen K, Gardner DG
J Steroid Biochem Mol Biol. 2010
PubMed ID: 20813185
CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples.
Yamashita Y, Kasugai I, Sato M, Tanuma N, Sato I, Nomura M, Yamashita K, Sonoda Y, Kumabe T, Tominaga T, Katakura R, Shima H
J Neurooncol. 2010
PubMed ID: 20217459
14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage.
Kasahara K, Goto H, Enomoto M, Tomono Y, Kiyono T, Inagaki M
EMBO J. 2010
PubMed ID: 20639859
MiR-322/424 and -503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A.
Sarkar S, Dey BK, Dutta A
Mol Biol Cell. 2010
PubMed ID: 20462953
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction.
Honaker Y, Piwnica-Worms H
Oncogene. 2010
PubMed ID: 20348946
Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain.
Chou ST, Yen YC, Lee CM, Chen MS
J Biol Chem. 2010
PubMed ID: 20368335
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.
Pereg Y, Liu BY, O'Rourke KM, Sagolla M, Dey A, Komuves L, French DM, Dixit VM
Nat Cell Biol. 2010
PubMed ID: 20228808
DNA damage-induced degradation of Cdc25A does not lead to inhibition of Cdk2 activity in mouse embryonic stem cells.
Koledova Z, Kafkova LR, Krämer A, Divoky V
Stem Cells. 2010
PubMed ID: 20104581
The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival.
Peschiaroli A, Skaar JR, Pagano M, Melino G
Oncogene. 2010
PubMed ID: 19966869
NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling.
Sørensen CS, Melixetian M, Klein DK, Helin K
Cell Cycle. 2010
PubMed ID: 20090422
Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells.
Lu S, Archer MC
Int J Cancer. 2010
PubMed ID: 19621387
Dual mode of regulation of cell division cycle 25 A protein by TRB3.
Sakai S, Ohoka N, Onozaki K, Kitagawa M, Nakanishi M, Hayashi H
Biol Pharm Bull. 2010
PubMed ID: 20606298
Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes.
Wang Z, Trope CG, Flørenes VA, Suo Z, Nesland JM, Holm R
BMC Cancer. 2010
PubMed ID: 20500813
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
Cunningham JM, Vierkant RA, Sellers TA, Phelan C, Rider DN, Liebow M, Schildkraut J, Berchuck A, Couch FJ, Wang X, Fridley BL, Ovarian Cancer Association Consortium, Gentry-Maharaj A, Menon U, Hogdall E, Kjaer S, Whittemore A, DiCioccio R, Song H, Gayther SA, Ramus SJ, Pharaoh PD, Goode EL
Br J Cancer. 2009
PubMed ID: 19738611
miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.
Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M, Yu Q
Genes Dev. 2009
PubMed ID: 19833767
Hypoxia-mediated regulation of Cdc25A phosphatase by p21 and miR-21.
de Oliveira PE, Zhang L, Wang Z, Lazo JS
Cell Cycle. 2009
PubMed ID: 19738433
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.
Melixetian M, Klein DK, Sørensen CS, Helin K
Nat Cell Biol. 2009
PubMed ID: 19734889
Prognostic implication of CDC25A and cyclin E expression on primary breast cancer patients.
Mehdipour P, Pirouzpanah S, Sarafnejad A, Atri M, Shahrestani ST, Haidari M
Cell Biol Int. 2009
PubMed ID: 19555767
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
Posttranscriptional regulation of CDC25A by BOLL is a conserved fertility mechanism essential for human spermatogenesis.
Lin YM, Chung CL, Cheng YS
J Clin Endocrinol Metab. 2009
PubMed ID: 19417033
Short 42 degrees C heat shock induces phosphorylation and degradation of Cdc25A which depends on p38MAPK, Chk2 and 14.3.3.
Madlener S, Rosner M, Krieger S, Giessrigl B, Gridling M, Vo TP, Leisser C, Lackner A, Raab I, Grusch M, Hengstschläger M, Dolznig H, Krupitza G
Hum Mol Genet. 2009
PubMed ID: 19289404
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Upregulation of the CDC25A phosphatase down-stream of the NPM/ALK oncogene participates to anaplastic large cell lymphoma enhanced proliferation.
Fernandez-Vidal A, Mazars A, Gautier EF, Prévost G, Payrastre B, Manenti S
Cell Cycle. 2009
PubMed ID: 19305144
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.
So HC, Fong PY, Chen RY, Hui TC, Ng MY, Cherny SS, Mak WW, Cheung EF, Chan RC, Chen EY, Li T, Sham PC
Am J Med Genet B Neuropsychiatr Genet. 2009
PubMed ID: 19367581
Silencing the Metallothionein-2A gene inhibits cell cycle progression from G1- to S-phase involving ATM and cdc25A signaling in breast cancer cells.
Lim D, Jocelyn KM, Yip GW, Bay BH
Cancer Lett. 2009
PubMed ID: 19062161
Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion.
Lee G, White LS, Hurov KE, Stappenbeck TS, Piwnica-Worms H
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19273838
Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control.
Demidova AR, Aau MY, Zhuang L, Yu Q
J Biol Chem. 2009
PubMed ID: 19060337
A caspase-dependent cleavage of CDC25A generates an active fragment activating cyclin-dependent kinase 2 during apoptosis.
Mazars A, Fernandez-Vidal A, Mondesert O, Lorenzo C, Prévost G, Ducommun B, Payrastre B, Racaud-Sultan C, Manenti S
Cell Death Differ. 2009
PubMed ID: 18927589
CDC25A functions as a novel Ar corepressor in prostate cancer cells.
Chiu YT, Han HY, Leung SC, Yuen HF, Chau CW, Guo Z, Qiu Y, Chan KW, Wang X, Wong YC, Ling MT
J Mol Biol. 2009
PubMed ID: 19013180
Cdc25A serine 123 phosphorylation couples centrosome duplication with DNA replication and regulates tumorigenesis.
Shreeram S, Hee WK, Bulavin DV
Mol Cell Biol. 2008
PubMed ID: 18936171
Aberrant Polo-like kinase 1-Cdc25A pathway in metastatic hepatocellular carcinoma.
Wang XQ, Zhu YQ, Lui KS, Cai Q, Lu P, Poon RT
Clin Cancer Res. 2008
PubMed ID: 18980975
Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer.
Aziz MH, Dreckschmidt NE, Verma AK
Cancer Res. 2008
PubMed ID: 18974148
MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease.
Lee SO, Masyuk T, Splinter P, Banales JM, Masyuk A, Stroope A, Larusso N
J Clin Invest. 2008
PubMed ID: 18949056
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
Multimodal control of Cdc25A by nitrosative stress.
Tomko RJ, Lazo JS
Cancer Res. 2008
PubMed ID: 18794133
Constitutive overexpression of CDC25A in primary human mammary epithelial cells results in both defective DNA damage response and chromosomal breaks at fragile sites.
Cangi MG, Piccinin S, Pecciarini L, Talarico A, Dal Cin E, Grassi S, Grizzo A, Maestro R, Doglioni C
Int J Cancer. 2008
PubMed ID: 18566993
Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase.
Jin J, Ang XL, Ye X, Livingstone M, Harper JW
J Biol Chem. 2008
PubMed ID: 18480045
Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S phase.
Stolfi C, Fina D, Caruso R, Caprioli F, Fantini MC, Rizzo A, Sarra M, Pallone F, Monteleone G
Carcinogenesis. 2008
PubMed ID: 18495657
Cdc25A promotes G2/M transition in oocytes.
Li M, Yin S, Yuan J, Wei L, Ai JS, Hou Y, Chen DY, Sun QY
Cell Cycle. 2008
PubMed ID: 18418039
CDC25A phosphatase controls meiosis I progression in mouse oocytes.
Solc P, Saskova A, Baran V, Kubelka M, Schultz RM, Motlik J
Dev Biol. 2008
PubMed ID: 18367163
Changes in gene expression induced by chemoradiation in advanced cervical carcinoma: a microarray study of RTOG C-0128.
Zempolich K, Fuhrman C, Milash B, Flinner R, Greven K, Ryu J, Forbes A, Kerlin K, Nichols RC, Gaffney DK
Gynecol Oncol. 2008
PubMed ID: 18299147
CDC25A phosphatase: a rate-limiting oncogene that determines genomic stability.
Ray D, Kiyokawa H
Cancer Res. 2008
PubMed ID: 18316586
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
CDC25A inhibition suppresses the growth and invasion of human hepatocellular carcinoma cells.
Xu X, Yamamoto H, Liu G, Ito Y, Ngan CY, Kondo M, Nagano H, Dono K, Sekimoto M, Monden M
Int J Mol Med. 2008
PubMed ID: 18204780
GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.
Kang T, Wei Y, Honaker Y, Yamaguchi H, Appella E, Hung MC, Piwnica-Worms H
Cancer Cell. 2008
PubMed ID: 18167338
CDC25A levels determine the balance of proliferation and checkpoint response.
Ray D, Kiyokawa H
Cell Cycle. 2007
PubMed ID: 18073536
The regulatory beta-subunit of protein kinase CK2 accelerates the degradation of CDC25A phosphatase through the checkpoint kinase Chk1.
Kreutzer J, Guerra B
Int J Oncol. 2007
PubMed ID: 17912454
Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryos.
Dackor J, Strunk KE, Wehmeyer MM, Threadgill DW
Placenta. 2007
PubMed ID: 17822758
Arsenite slows S phase progression via inhibition of cdc25A dual specificity phosphatase gene transcription.
Lehmann GM, McCabe MJ
Toxicol Sci. 2007
PubMed ID: 17545210
Hypoxic suppression of the cell cycle gene CDC25A in tumor cells.
Hammer S, To KK, Yoo YG, Koshiji M, Huang LE
Cell Cycle. 2007
PubMed ID: 17671423
Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice.
Ray D, Terao Y, Nimbalkar D, Hirai H, Osmundson EC, Zou X, Franks R, Christov K, Kiyokawa H
Cancer Res. 2007
PubMed ID: 17638870
p53 downregulates expression of the G1/S cell cycle phosphatase Cdc25A.
Rother K, Kirschner R, Sänger K, Böhlig L, Mössner J, Engeland K
Oncogene. 2007
PubMed ID: 17001315
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.
Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB
Cancer Cell. 2007
PubMed ID: 17292828
Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability.
Ray D, Terao Y, Fuhrken PG, Ma ZQ, DeMayo FJ, Christov K, Heerema NA, Franks R, Tsai SY, Papoutsakis ET, Kiyokawa H
Cancer Res. 2007
PubMed ID: 17283130
Independent mechanistic inhibition of cdc25 phosphatases by a natural product caulibugulone.
Brisson M, Foster C, Wipf P, Joo B, Tomko RJ, Nguyen T, Lazo JS
Mol Pharmacol. 2007
PubMed ID: 17018577
Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320.
Esteban V, Vázquez-Novelle MD, Calvo E, Bueno A, Sacristán MP
Cell Cycle. 2006
PubMed ID: 17172867
HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer.
Lokeshwar VB, Estrella V, Lopez L, Kramer M, Gomez P, Soloway MS, Lokeshwar BL
Cancer Res. 2006
PubMed ID: 17145867
The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism.
Liu P, Barkley LR, Day T, Bi X, Slater DM, Alexandrow MG, Nasheuer HP, Vaziri C
J Biol Chem. 2006
PubMed ID: 16912045
p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling.
Hulit J, Lee RJ, Li Z, Wang C, Katiyar S, Yang J, Quong AA, Wu K, Albanese C, Russell R, Di Vizio D, Koff A, Thummala S, Zhang H, Harrell J, Sun H, Muller WJ, Inghirami G, Lisanti MP, Pestell RG
Cancer Res. 2006
PubMed ID: 16951165
Association of spermatogenic failure with decreased CDC25A expression in infertile men.
Cheng YS, Kuo PL, Teng YN, Kuo TY, Chung CL, Lin YH, Liao RW, Lin JS, Lin YM
Hum Reprod. 2006
PubMed ID: 16720623
17beta-estradiol (E2) induces cdc25A gene expression in breast cancer cells by genomic and non-genomic pathways.
Ru Lee W, Chen CC, Liu S, Safe S
J Cell Biochem. 2006
PubMed ID: 16598773
The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin.
Zhang Y, Qu D, Morris EJ, O'Hare MJ, Callaghan SM, Slack RS, Geller HM, Park DS
J Neurosci. 2006
PubMed ID: 16928871
Bifunctional role of the leishmanial antimonate reductase LmACR2 as a protein tyrosine phosphatase.
Zhou Y, Bhattacharjee H, Mukhopadhyay R
Mol Biochem Parasitol. 2006
PubMed ID: 16644029
The DNA sequence, annotation and analysis of human chromosome 3.
Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA
Nature. 2006
PubMed ID: 16641997
The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C.
Bachmann M, Kosan C, Xing PX, Montenarh M, Hoffmann I, Möröy T
Int J Biochem Cell Biol. 2006
PubMed ID: 16356754
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
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Science. 2005
PubMed ID: 16141072
Cytokine-driven cell cycling is mediated through Cdc25A.
Khaled AR, Bulavin DV, Kittipatarin C, Li WQ, Alvarez M, Kim K, Young HA, Fornace AJ, Durum SK
J Cell Biol. 2005
PubMed ID: 15928203
Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner.
Ray D, Terao Y, Nimbalkar D, Chu LH, Donzelli M, Tsutsui T, Zou X, Ghosh AK, Varga J, Draetta GF, Kiyokawa H
Mol Cell Biol. 2005
PubMed ID: 15798217
PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts.
Cairo S, De Falco F, Pizzo M, Salomoni P, Pandolfi PP, Meroni G
Oncogene. 2005
PubMed ID: 15735755
Cdc25A localisation and shuttling: characterisation of sequences mediating nuclear export and import.
Källström H, Lindqvist A, Pospisil V, Lundgren A, Rosenthal CK
Exp Cell Res. 2005
PubMed ID: 15572030
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase.
Krämer A, Mailand N, Lukas C, Syljuåsen RG, Wilkinson CJ, Nigg EA, Bartek J, Lukas J
Nat Cell Biol. 2004
PubMed ID: 15311285
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
Meek SE, Lane WS, Piwnica-Worms H
J Biol Chem. 2004
PubMed ID: 15161933
Activation of cell cycle regulatory proteins in the apoptosis of terminally differentiated oligodendrocytes.
Strazza M, Luddi A, Brogi A, Carbone M, Riccio M, Santi S, Melli M, Costantino-Ceccarini E
Neurochem Res. 2004
PubMed ID: 15139290
A fission yeast strain expressing human CDC25A phosphatase: a tool for selectivity studies of pharmacological inhibitors of CDC25.
Mondesert O, Lemaire M, Brezak MC, Galera-Contour MO, Prevost G, Ducommun B, Bugler B
Curr Genet. 2004
PubMed ID: 14727060
Suppression of WEE1 and stimulation of CDC25A correlates with endothelin-dependent proliferation of rat aortic smooth muscle cells.
Chen S, Gardner DG
J Biol Chem. 2004
PubMed ID: 14742443
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
Cdc25A and cdc25B expression in malignant lymphoma of the thyroid: correlation with histological subtypes and cell proliferation.
Ito Y, Yoshida H, Matsuzuka F, Matsuura N, Nakamura Y, Nakamine H, Kakudo K, Kuma K, Miyauchi A
Int J Mol Med. 2004
PubMed ID: 14767575
DNA damage tumor suppressor genes and genomic instability.
Motoyama N, Naka K
Curr Opin Genet Dev. 2004
PubMed ID: 15108799
Activation of the Raf-1/MEK/Erk kinase pathway by a novel Cdc25 inhibitor in human prostate cancer cells.
Nemoto K, Vogt A, Oguri T, Lazo JS
Prostate. 2004
PubMed ID: 14673957
TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest.
Bhowmick NA, Ghiassi M, Aakre M, Brown K, Singh V, Moses HL
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14657354
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.
Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW
Genes Dev. 2003
PubMed ID: 14681206
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.
Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF
Nature. 2003
PubMed ID: 14603323
Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.
Chen MS, Ryan CE, Piwnica-Worms H
Mol Cell Biol. 2003
PubMed ID: 14559997
DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase.
Chow JP, Siu WY, Fung TK, Chan WM, Lau A, Arooz T, Ng CP, Yamashita K, Poon RY
Mol Biol Cell. 2003
PubMed ID: 14517313
Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint.
Goloudina A, Yamaguchi H, Chervyakova DB, Appella E, Fornace AJ, Bulavin DV
Cell Cycle. 2003
PubMed ID: 12963847
Regulation of Cdc25A half-life in interphase by cyclin-dependent kinase 2 activity.
Ducruet AP, Lazo JS
J Biol Chem. 2003
PubMed ID: 12801928
Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint.
Hassepass I, Voit R, Hoffmann I
J Biol Chem. 2003
PubMed ID: 12759351
Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.
Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, Zhang H
J Biol Chem. 2003
PubMed ID: 12676925
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.
Zou L, Elledge SJ
Science. 2003
PubMed ID: 12791985
Overexpression of CDC25A phosphatase is associated with hypergrowth activity and poor prognosis of human hepatocellular carcinomas.
Xu X, Yamamoto H, Sakon M, Yasui M, Ngan CY, Fukunaga H, Morita T, Ogawa M, Nagano H, Nakamori S, Sekimoto M, Matsuura N, Monden M
Clin Cancer Res. 2003
PubMed ID: 12738732
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.
Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou BB, Bartek J, Lukas J
Cancer Cell. 2003
PubMed ID: 12676583
Regulation of the mammalian cell cycle: a model of the G1-to-S transition.
Qu Z, Weiss JN, MacLellan WR
Am J Physiol Cell Physiol. 2003
PubMed ID: 12388094
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells.
Melkun E, Pilione M, Paulson RF
Blood. 2002
PubMed ID: 12411323
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.
Zhao H, Watkins JL, Piwnica-Worms H
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12399544
Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.
Mailand N, Podtelejnikov AV, Groth A, Mann M, Bartek J, Lukas J
EMBO J. 2002
PubMed ID: 12411508
Dual mode of degradation of Cdc25 A phosphatase.
Donzelli M, Squatrito M, Ganoth D, Hershko A, Pagano M, Draetta GF
EMBO J. 2002
PubMed ID: 12234927
Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6.
Mitchem KL, Hibbard E, Beyer LA, Bosom K, Dootz GA, Dolan DF, Johnson KR, Raphael Y, Kohrman DC
Hum Mol Genet. 2002
PubMed ID: 12140191
Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition.
Shimuta K, Nakajo N, Uto K, Hayano Y, Okazaki K, Sagata N
EMBO J. 2002
PubMed ID: 12110582
A bioinformatics-based strategy identifies c-Myc and Cdc25A as candidates for the Apmt mammary tumor latency modifiers.
Cozma D, Lukes L, Rouse J, Qiu TH, Liu ET, Hunter KW
Genome Res. 2002
PubMed ID: 12045150
Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase.
Wang Z, Wang M, Lazo JS, Carr BI
J Biol Chem. 2002
PubMed ID: 11912208
The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers.
Jaime M, Pujol MJ, Serratosa J, Pantoja C, Canela N, Casanovas O, Serrano M, Agell N, Bachs O
Hepatology. 2002
PubMed ID: 11981756
The catalytic mechanism of Cdc25A phosphatase.
McCain DF, Catrina IE, Hengge AC, Zhang ZY
J Biol Chem. 2002
PubMed ID: 11805096
Human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest.
Nguyen DX, Westbrook TF, McCance DJ
J Virol. 2002
PubMed ID: 11752153
Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2).
Santaguida M, Ding Q, Bérubé G, Truscott M, Whyte P, Nepveu A
J Biol Chem. 2001
PubMed ID: 11584018
Involvement of Cdc25A phosphatase in Hep3B hepatoma cell growth inhibition induced by novel K vitamin analogs.
Wang Z, Southwick EC, Wang M, Kar S, Rosi KS, Wilcox CS, Lazo JS, Carr BI
Cancer Res. 2001
PubMed ID: 11585757
The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1.
Zou X, Tsutsui T, Ray D, Blomquist JF, Ichijo H, Ucker DS, Kiyokawa H
Mol Cell Biol. 2001
PubMed ID: 11416155
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.
Falck J, Mailand N, Syljuåsen RG, Bartek J, Lukas J
Nature. 2001
PubMed ID: 11298456
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Structure and promoter activity of the mouse CDC25A gene.
Paskind M, Johnston C, Epstein PM, Timm J, Wickramasinghe D, Belanger E, Rodman L, Magada D, Voss J
Mamm Genome. 2000
PubMed ID: 11130973
The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease.
Ding XL, Husseman J, Tomashevski A, Nochlin D, Jin LW, Vincent I
Am J Pathol. 2000
PubMed ID: 11106571
Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C.
Wegener S, Hampe W, Herrmann D, Schaller HC
Eur J Cell Biol. 2000
PubMed ID: 11139144
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice.
Liu D, Liao C, Wolgemuth DJ
Dev Biol. 2000
PubMed ID: 10926775
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Rapid destruction of human Cdc25A in response to DNA damage.
Mailand N, Falck J, Lukas C, Syljuâsen RG, Welcker M, Bartek J, Lukas J
Science. 2000
PubMed ID: 10827953
Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression.
Takahashi Y, Rayman JB, Dynlacht BD
Genes Dev. 2000
PubMed ID: 10766737
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
Cell cycle regulation by the Cdc25 phosphatase family.
Nilsson I, Hoffmann I
Prog Cell Cycle Res. 2000
PubMed ID: 10740819
CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase.
Vigo E, Müller H, Prosperini E, Hateboer G, Cartwright P, Moroni MC, Helin K
Mol Cell Biol. 1999
PubMed ID: 10454584
Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases.
Blomberg I, Hoffmann I
Mol Cell Biol. 1999
PubMed ID: 10454565
Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A.
Xia K, Lee RS, Narsimhan RP, Mukhopadhyay NK, Neel BG, Roberts TM
Mol Cell Biol. 1999
PubMed ID: 10373531
Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway.
Mochizuki T, Kitanaka C, Noguchi K, Muramatsu T, Asai A, Kuchino Y
J Biol Chem. 1999
PubMed ID: 10373478
Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1 (VPAC1) receptor.
Hashimoto H, Nishino A, Shintani N, Hagihara N, Copeland NG, Jenkins NA, Yamamoto K, Matsuda T, Ishihara T, Nagata S, Baba A
Genomics. 1999
PubMed ID: 10331949
Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest.
Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E
Mol Cell Biol. 1999
PubMed ID: 9891079
A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2.
Sexl V, Diehl JA, Sherr CJ, Ashmun R, Beach D, Roussel MF
Oncogene. 1999
PubMed ID: 9989807
E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest.
Iavarone A, Massagué J
Mol Cell Biol. 1999
PubMed ID: 9858615
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Cell cycle targets of Ras/Raf signalling.
Kerkhoff E, Rapp UR
Oncogene. 1998
PubMed ID: 9779991
The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phase.
Coqueret O, Bérubé G, Nepveu A
EMBO J. 1998
PubMed ID: 9707427
Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A.
Fauman EB, Cogswell JP, Lovejoy B, Rocque WJ, Holmes W, Montana VG, Piwnica-Worms H, Rink MJ, Saper MA
Cell. 1998
PubMed ID: 9604936
Phosphatases and tumorigenesis.
Parsons R
Curr Opin Oncol. 1998
PubMed ID: 9466490
Genetic structure and chromosomal mapping of MyD88.
Hardiman G, Jenkins NA, Copeland NG, Gilbert DJ, Garcia DK, Naylor SL, Kastelein RA, Bazan JF
Genomics. 1997
PubMed ID: 9344657
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.
Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ
Science. 1997
PubMed ID: 9278511
Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced apoptosis.
Huang TS, Shu CH, Yang WK, Whang-Peng J
Cancer Res. 1997
PubMed ID: 9230211
The Cdc25 genes map to mouse chromosomes 2, 9, and 18.
Lock LF, Wickramasinghe D, Ernst MK, Gilbert DJ, Copeland NG, Jenkins NA, Donovan PJ
Mamm Genome. 1996
PubMed ID: 8854867
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest.
Tiefenbrun N, Melamed D, Levy N, Resnitzky D, Hoffman I, Reed SI, Kimchi A
Mol Cell Biol. 1996
PubMed ID: 8668211
Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25.
Xu X, Burke SP
J Biol Chem. 1996
PubMed ID: 8617791
CDC25 phosphatases as potential human oncogenes.
Galaktionov K, Lee AK, Eckstein J, Draetta G, Meckler J, Loda M, Beach D
Science. 1995
PubMed ID: 7667636
14-3-3 proteins associate with cdc25 phosphatases.
Conklin DS, Galaktionov K, Beach D
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7644510
Two CDC25 homologues are differentially expressed during mouse development.
Wickramasinghe D, Becker S, Ernst MK, Resnick JL, Centanni JM, Tessarollo L, Grabel LB, Donovan PJ
Development. 1995
PubMed ID: 7635051
Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation.
Galaktionov K, Jessus C, Beach D
Genes Dev. 1995
PubMed ID: 7744247
Genetic mapping of the mouse CDC25Mm gene, a ras-specific guanine nucleotide-releasing factor, to chromosome 9.
Gariboldi M, Sturani E, Canzian F, De Gregorio L, Manenti G, Dragani TA, Pierotti MA
Genomics. 1994
PubMed ID: 8088844
Cdc25A is a novel phosphatase functioning early in the cell cycle.
Jinno S, Suto K, Nagata A, Igarashi M, Kanaoka Y, Nojima H, Okayama H
EMBO J. 1994
PubMed ID: 8156993
Chromosome mapping of human CDC25A and CDC25B phosphatases.
Demetrick DJ, Beach DH
Genomics. 1993
PubMed ID: 8276402
Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins.
Galaktionov K, Beach D
Cell. 1991
PubMed ID: 1836978
Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein.
Strausfeld U, Labbé JC, Fesquet D, Cavadore JC, Picard A, Sadhu K, Russell P, Dorée M
Nature. 1991
PubMed ID: 1828290

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	993	12530	171102
EnsEMBL Gene(s)	ENSG00000164045	ENSMUSG00000032477	ENSRNOG00000020737
Unigene	Hs.437705	Mm.307103	Rn.11390
Homologene	CDC25A	Cdc25a	Cdc25a
OMIM	116947	N/A	N/A
GeneCards	CDC25A	N/A	N/A
Beta Cell Genomics	DT.209227 DT.306884	DT.101305140 DT.533614 DT.94276577	N/A
Reactome	P30304	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	993	12530	171102

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
CDC25A	CDK2	HPRD, BioGRID	empirical	8617791 12388094
CDC25A	CDKN3	HPRD	empirical	9989807
CDC25A	YWHAQ	BioGRID	empirical	15161933
CDC25A	CCNI	IntAct	empirical	21988832
CDC25A	CHEK1	HPRD, IntAct, BioGRID	empirical	12399544 12676583 17292828 12963847 9278511 18480045 12759351
CDC25A	CHEK2	HPRD, MINT	empirical	12676583 11298456 10724175
CDC25A	MAPK14	BioGRID	empirical	12963847
CDC25A	CUX1	HPRD	empirical	11584018
CDC25A	DMD	IntAct	empirical	21988832
CDC25A	DUSP8	BioGRID	empirical	21900206
CDC25A	EEF1A1	IntAct	empirical	21988832
CDC25A	EGFR	HPRD, BioGRID	empirical	11912208
CDC25A	FBXW11	HPRD, MINT, BioGRID	empirical	14603323 15798217 14681206
CDC25A	FTH1	IntAct	empirical	21988832
CDC25A	FGF21	IntAct	empirical	21988832
CDC25A	HLA-C	IntAct	empirical	21988832
CDC25A	HRAS	HPRD	empirical	7744247
CDC25A	IL3RA	IntAct	empirical	21988832
CDC25A	AR	HPRD	empirical	19013180
CDC25A	LMO2	IntAct	empirical	21988832
CDC25A	SMAD3	HPRD, IntAct, BioGRID	empirical	15798217 21988832
CDC25A	MAP3K5	HPRD, BioGRID	empirical	11416155
CDC25A	MTAP	IntAct	empirical	21988832
CDC25A	NFKBIB	IntAct	empirical	21988832
CDC25A	NFYA	IntAct	empirical	21988832
CDC25A	OTX2	Sanger Interaction Map	predicted	15345047
CDC25A	POLR1D	IntAct	empirical	21988832
CDC25A	PIM1	HPRD, BioGRID	empirical	10373478 12411508
CDC25A	FAM193B	BioGRID	empirical	21900206
CDC25A	CAMK1D	IntAct	empirical	21988832
CDC25A	SCYL1	IntAct	empirical	21988832
CDC25A	PEX19	IntAct	empirical	21988832
CDC25A	RAF1	HPRD, IntAct, BioGRID	empirical	9230211 10373531 7644510 7744247
CDC25A	ROCK1	HPRD, BioGRID	empirical	14657354
CDC25A	SOX5	IntAct	empirical	21988832
CDC25A	UBA52	Reactome	predicted
CDC25A	UBB	HPRD, Reactome	empirical	10827953 12234927
CDC25A	UBC	BioGRID, Reactome	empirical	18495657 15798217 14681206 21963094 21906983
CDC25A	XPO1	IntAct	empirical	21988832
CDC25A	YWHAB	HPRD, IntAct, BioGRID	empirical	7644510
CDC25A	YWHAE	HPRD, MINT, IntAct, BioGRID	empirical	7644510 14559997
CDC25A	YWHAZ	HPRD, MINT, BioGRID	empirical	11912208 15161933
CDC25A	NAA10	HPRD, MINT, IntAct, BioGRID	empirical	16189514
CDC25A	CUL3	IntAct	empirical	21988832
CDC25A	CUL1	BioGRID	empirical	14681206
CDC25A	VAMP8	IntAct	empirical	21988832
CDC25A	MCM3AP	IntAct	empirical	21988832
CDC25A	CCNA1	HPRD, BioGRID	empirical	10926775
CDC25A	CCNB1	HPRD, BioGRID	empirical	1836978
CDC25A	BTRC	HPRD, MINT, IntAct, BioGRID	empirical	14603323 19615732 15798217 14681206
CDC25A	CCNE1	HPRD, BioGRID	empirical	8617791 9891079
CDC25A	MAPKAPK2	IntAct	empirical	17292828
CDC25A	CDK1	HPRD	empirical	12411508