CDK1

Summary Top Help

Gene Description:

cyclin-dependent kinase 1

Synonyms:

Cdc2a, Cdc2, P34CDC2, p34, CDK1, CDC2, Cdk1, CDC28A

Orthologs:

Human CDK1 (protein-coding), Mouse Cdk1 (protein-coding), Rat Cdk1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr10:62538089..62554610 (16.52 kb) View in Genome Browser

(Mouse) NCBIM37 - chr10:68799383..68815686 (16.30 kb) View in Genome Browser

(Rat) RGSC3.4 - chr20:20018044..20044030 (25.99 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CDK1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CDK1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 5

Biocarta: 13

Reactome: 58

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	REACT_6954
APC/C-mediated degradation of cell cycle proteins	REACT_6828
APC/C:Cdc20 mediated degradation of Cyclin B	REACT_6820
APC/C:Cdc20 mediated degradation of mitotic proteins	REACT_6781
ARMS-mediated activation	REACT_12002
Axon guidance	REACT_18266
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	REACT_6850
Cell Cycle Checkpoints	REACT_1538
Cell Cycle, Mitotic	REACT_152
Centrosome maturation	REACT_15479
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	REACT_407
Cyclin A/B1 associated events during G2/M transition	REACT_1857
Cyclin B2 mediated events	REACT_2101
Down-stream signal transduction	REACT_17025
E2F mediated regulation of DNA replication	REACT_471
E2F-enabled inhibition of pre-replication complex formation	REACT_1321
ERK activation	REACT_1482
ERK1 activation	REACT_1391
Frs2-mediated activation	REACT_12076
G1/S Transition	REACT_1783
G1/S-Specific Transcription	REACT_683
G2/M Checkpoints	REACT_828
G2/M DNA damage checkpoint	REACT_897
G2/M DNA replication checkpoint	REACT_1846
G2/M Transition	REACT_2203
Grb2 events in EGFR signaling	REACT_12606
Insulin receptor signalling cascade	REACT_1195
IRS-mediated signalling	REACT_332
IRS-related events	REACT_762
Loss of Nlp from mitotic centrosomes	REACT_15364
Loss of proteins required for interphase microtubule organization�from the centrosome	REACT_15451
MAP kinase cascade	REACT_634
MAP kinases activation in TLR cascade	REACT_21308
Mitotic G1-G1/S phases	REACT_21267
Mitotic G2-G2/M phases	REACT_21391
NCAM signaling for neurite out-growth	REACT_18334
NGF signalling via TRKA from the plasma membrane	REACT_12056
Phosphorylation of Emi1	REACT_6875
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes	REACT_6362
Phosphorylation of the APC/C	REACT_6904
Prolonged ERK activation events	REACT_12005
Recruitment of mitotic centrosome proteins and complexes	REACT_15296
Recruitment of NuMA to mitotic centrosomes	REACT_15510
Regulation of APC/C activators between G1/S and early anaphase	REACT_6837
Regulation of mitotic cell cycle	REACT_21279
Shc events in EGFR signaling	REACT_12579
SHC-mediated signalling	REACT_661
SHC-related events	REACT_999
Signaling by EGFR	REACT_9417
Signaling by Insulin receptor	REACT_498
Signaling by PDGF	REACT_16888
Signalling by NGF	REACT_11061
Signalling to ERKs	REACT_12058
Signalling to p38 via RIT and RIN	REACT_12077
Signalling to RAS	REACT_12033
SOS-mediated signalling	REACT_524
Toll Like Receptor 3 (TLR3) Cascade	REACT_6783
TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade	REACT_6782

NCI-Nature Pathway Interaction Database: 6

Gene Ontology: 81

Cell cycle checkpoint	GO:0000075
G1/S transition of mitotic cell cycle	GO:0000082
Regulation of transcription involved in G1/S phase of mitotic cell cycle	GO:0000083
G2/M transition of mitotic cell cycle	GO:0000086
MAPK cascade	GO:0000165
Nucleotide binding	GO:0000166
Activation of MAPKK activity	GO:0000186
Activation of MAPK activity	GO:0000187
Microtubule cytoskeleton organization	GO:0000226
Mitotic cell cycle	GO:0000278
Toll-like receptor signaling pathway	GO:0002224
MyD88-dependent toll-like receptor signaling pathway	GO:0002755
MyD88-independent toll-like receptor signaling pathway	GO:0002756
Protein kinase activity	GO:0004672
Cyclin-dependent protein kinase activity	GO:0004693
Protein binding	GO:0005515
ATP binding	GO:0005524
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Cytoplasm	GO:0005737
Mitochondrion	GO:0005739
Cytosol	GO:0005829
Spindle microtubule	GO:0005876
DNA replication	GO:0006260
DNA repair	GO:0006281
Protein complex assembly	GO:0006461
Protein phosphorylation	GO:0006468
Apoptotic process	GO:0006915
Anti-apoptosis	GO:0006916
Cell cycle	GO:0007049
Mitosis	GO:0007067
Mitotic cell cycle G2/M transition DNA damage checkpoint	GO:0007095
Centrosome cycle	GO:0007098
Epidermal growth factor receptor signaling pathway	GO:0007173
Small GTPase mediated signal transduction	GO:0007264
Ras protein signal transduction	GO:0007265
Pronuclear fusion	GO:0007344
Axon guidance	GO:0007411
Cell aging	GO:0007569
Toll signaling pathway	GO:0008063
Insulin receptor signaling pathway	GO:0008286
RNA polymerase II carboxy-terminal domain kinase activity	GO:0008353
Fibroblast growth factor receptor signaling pathway	GO:0008543
Response to toxin	GO:0009636
Positive regulation of gene expression	GO:0010628
Regulation of Schwann cell differentiation	GO:0014038
Response to organic cyclic compound	GO:0014070
Response to amine stimulus	GO:0014075
Response to activity	GO:0014823
Cell migration	GO:0016477
Chromosome condensation	GO:0030261
Cyclin binding	GO:0030332
Midbody	GO:0030496
Hsp70 protein binding	GO:0030544
Organ regeneration	GO:0031100
Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	GO:0031145
Positive regulation of protein import into nucleus, translocation	GO:0033160
Toll-like receptor 1 signaling pathway	GO:0034130
Toll-like receptor 2 signaling pathway	GO:0034134
Toll-like receptor 3 signaling pathway	GO:0034138
Toll-like receptor 4 signaling pathway	GO:0034142
Protein localization to kinetochore	GO:0034501
Histone kinase activity	GO:0035173
TRIF-dependent toll-like receptor signaling pathway	GO:0035666
Response to drug	GO:0042493
Innate immune response	GO:0045087
Response to ethanol	GO:0045471
Positive regulation of DNA replication	GO:0045740
Positive regulation of mitotic cell cycle	GO:0045931
Regulation of embryonic development	GO:0045995
Response to cadmium ion	GO:0046686
Response to copper ion	GO:0046688
Nerve growth factor receptor signaling pathway	GO:0048011
Response to axon injury	GO:0048678
Cell division	GO:0051301
Stress-activated MAPK cascade	GO:0051403
Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:0051437
Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:0051439
Ventricular cardiac muscle cell development	GO:0055015
Positive regulation of cardiac muscle cell proliferation	GO:0060045
Cellular response to hydrogen peroxide	GO:0070301

KEGG Network: 5
Cell cycle	Human - 4110	Mouse - 4110	Rat - 4110
Gap junction	Human - 4540	Mouse - 4540	Rat - 4540
Oocyte meiosis	Human - 4114	Mouse - 4114	Rat - 4114
p53 signaling pathway	Human - 4115	Mouse - 4115	Rat - 4115
Progesterone-mediated oocyte maturation	Human - 4914	Mouse - 4914	Rat - 4914

Biocarta: 13
Activation of Src by Protein-tyrosine phosphatase alpha	Human	Mouse
AKAP95 role in mitosis and chromosome dynamics	Human	Mouse
cdc25 and chk1 Regulatory Pathway in response to DNA damage	Human	Mouse
Cell Cycle: G1/S Check Point	Human	Mouse
Cell Cycle: G2/M Checkpoint	Human	Mouse
Cyclins and Cell Cycle Regulation	Human	Mouse
Estrogen-responsive protein Efp controls cell cycle and breast tumors growth	Human	Mouse
How Progesterone Initiates the Oocyte Maturation	Human	Mouse
Protein Kinase A at the Centrosome	Human	Mouse
RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage	Human	Mouse
Regulation of Splicing through Sam68	Human	Mouse
Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle	Human	Mouse
Stathmin and breast cancer resistance to antimicrotubule agents	Human	Mouse

Reactome: 58
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	REACT_6954
APC/C-mediated degradation of cell cycle proteins	REACT_6828
APC/C:Cdc20 mediated degradation of Cyclin B	REACT_6820
APC/C:Cdc20 mediated degradation of mitotic proteins	REACT_6781
ARMS-mediated activation	REACT_12002
Axon guidance	REACT_18266
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	REACT_6850
Cell Cycle Checkpoints	REACT_1538
Cell Cycle, Mitotic	REACT_152
Centrosome maturation	REACT_15479
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	REACT_407
Cyclin A/B1 associated events during G2/M transition	REACT_1857
Cyclin B2 mediated events	REACT_2101
Down-stream signal transduction	REACT_17025
E2F mediated regulation of DNA replication	REACT_471
E2F-enabled inhibition of pre-replication complex formation	REACT_1321
ERK activation	REACT_1482
ERK1 activation	REACT_1391
Frs2-mediated activation	REACT_12076
G1/S Transition	REACT_1783
G1/S-Specific Transcription	REACT_683
G2/M Checkpoints	REACT_828
G2/M DNA damage checkpoint	REACT_897
G2/M DNA replication checkpoint	REACT_1846
G2/M Transition	REACT_2203
Grb2 events in EGFR signaling	REACT_12606
Insulin receptor signalling cascade	REACT_1195
IRS-mediated signalling	REACT_332
IRS-related events	REACT_762
Loss of Nlp from mitotic centrosomes	REACT_15364
Loss of proteins required for interphase microtubule organization�from the centrosome	REACT_15451
MAP kinase cascade	REACT_634
MAP kinases activation in TLR cascade	REACT_21308
Mitotic G1-G1/S phases	REACT_21267
Mitotic G2-G2/M phases	REACT_21391
NCAM signaling for neurite out-growth	REACT_18334
NGF signalling via TRKA from the plasma membrane	REACT_12056
Phosphorylation of Emi1	REACT_6875
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes	REACT_6362
Phosphorylation of the APC/C	REACT_6904
Prolonged ERK activation events	REACT_12005
Recruitment of mitotic centrosome proteins and complexes	REACT_15296
Recruitment of NuMA to mitotic centrosomes	REACT_15510
Regulation of APC/C activators between G1/S and early anaphase	REACT_6837
Regulation of mitotic cell cycle	REACT_21279
Shc events in EGFR signaling	REACT_12579
SHC-mediated signalling	REACT_661
SHC-related events	REACT_999
Signaling by EGFR	REACT_9417
Signaling by Insulin receptor	REACT_498
Signaling by PDGF	REACT_16888
Signalling by NGF	REACT_11061
Signalling to ERKs	REACT_12058
Signalling to p38 via RIT and RIN	REACT_12077
Signalling to RAS	REACT_12033
SOS-mediated signalling	REACT_524
Toll Like Receptor 3 (TLR3) Cascade	REACT_6783
TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade	REACT_6782

NCI-Nature Pathway Interaction Database: 6

E2F transcription factor network

PLK1 signaling events

AP-1 transcription factor network

FOXM1 transcription factor network

Retinoic acid receptors-mediated signaling

p73 transcription factor network

Gene Ontology: 81
Cell cycle checkpoint	GO:0000075
G1/S transition of mitotic cell cycle	GO:0000082
Regulation of transcription involved in G1/S phase of mitotic cell cycle	GO:0000083
G2/M transition of mitotic cell cycle	GO:0000086
MAPK cascade	GO:0000165
Nucleotide binding	GO:0000166
Activation of MAPKK activity	GO:0000186
Activation of MAPK activity	GO:0000187
Microtubule cytoskeleton organization	GO:0000226
Mitotic cell cycle	GO:0000278
Toll-like receptor signaling pathway	GO:0002224
MyD88-dependent toll-like receptor signaling pathway	GO:0002755
MyD88-independent toll-like receptor signaling pathway	GO:0002756
Protein kinase activity	GO:0004672
Cyclin-dependent protein kinase activity	GO:0004693
Protein binding	GO:0005515
ATP binding	GO:0005524
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Cytoplasm	GO:0005737
Mitochondrion	GO:0005739
Cytosol	GO:0005829
Spindle microtubule	GO:0005876
DNA replication	GO:0006260
DNA repair	GO:0006281
Protein complex assembly	GO:0006461
Protein phosphorylation	GO:0006468
Apoptotic process	GO:0006915
Anti-apoptosis	GO:0006916
Cell cycle	GO:0007049
Mitosis	GO:0007067
Mitotic cell cycle G2/M transition DNA damage checkpoint	GO:0007095
Centrosome cycle	GO:0007098
Epidermal growth factor receptor signaling pathway	GO:0007173
Small GTPase mediated signal transduction	GO:0007264
Ras protein signal transduction	GO:0007265
Pronuclear fusion	GO:0007344
Axon guidance	GO:0007411
Cell aging	GO:0007569
Toll signaling pathway	GO:0008063
Insulin receptor signaling pathway	GO:0008286
RNA polymerase II carboxy-terminal domain kinase activity	GO:0008353
Fibroblast growth factor receptor signaling pathway	GO:0008543
Response to toxin	GO:0009636
Positive regulation of gene expression	GO:0010628
Regulation of Schwann cell differentiation	GO:0014038
Response to organic cyclic compound	GO:0014070
Response to amine stimulus	GO:0014075
Response to activity	GO:0014823
Cell migration	GO:0016477
Chromosome condensation	GO:0030261
Cyclin binding	GO:0030332
Midbody	GO:0030496
Hsp70 protein binding	GO:0030544
Organ regeneration	GO:0031100
Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	GO:0031145
Positive regulation of protein import into nucleus, translocation	GO:0033160
Toll-like receptor 1 signaling pathway	GO:0034130
Toll-like receptor 2 signaling pathway	GO:0034134
Toll-like receptor 3 signaling pathway	GO:0034138
Toll-like receptor 4 signaling pathway	GO:0034142
Protein localization to kinetochore	GO:0034501
Histone kinase activity	GO:0035173
TRIF-dependent toll-like receptor signaling pathway	GO:0035666
Response to drug	GO:0042493
Innate immune response	GO:0045087
Response to ethanol	GO:0045471
Positive regulation of DNA replication	GO:0045740
Positive regulation of mitotic cell cycle	GO:0045931
Regulation of embryonic development	GO:0045995
Response to cadmium ion	GO:0046686
Response to copper ion	GO:0046688
Nerve growth factor receptor signaling pathway	GO:0048011
Response to axon injury	GO:0048678
Cell division	GO:0051301
Stress-activated MAPK cascade	GO:0051403
Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:0051437
Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:0051439
Ventricular cardiac muscle cell development	GO:0055015
Positive regulation of cardiac muscle cell proliferation	GO:0060045
Cellular response to hydrogen peroxide	GO:0070301

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 637

Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration.
Chu R, Terrano DT, Chambers TC
Biochem Pharmacol. 2012
PubMed ID: 22024133
CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL.
Gilley R, Lochhead PA, Balmanno K, Oxley D, Clark J, Cook SJ
Cell Signal. 2012
PubMed ID: 21924351
The cdk1-cyclin B complex is involved in everolimus triggered resistance in the PC3 prostate cancer cell line.
Tsaur I, Makarević J, Hudak L, Juengel E, Kurosch M, Wiesner C, Bartsch G, Harder S, Haferkamp A, Blaheta RA
Cancer Lett. 2011
PubMed ID: 21925791
Heat shock protein 90 stabilizes nucleolin to increase mRNA stability in mitosis.
Wang SA, Li HY, Hsu TI, Chen SH, Wu CJ, Chang WC, Hung JJ
J Biol Chem. 2011
PubMed ID: 21998300
Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis.
Zhuang C, Tang H, Dissanaike S, Cobos E, Tao Y, Dai Z
J Biol Chem. 2011
PubMed ID: 21900237
Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation.
Coulonval K, Kooken H, Roger PP
Mol Biol Cell. 2011
PubMed ID: 21900495
Evidence that phosphorylation by the mitotic kinase Cdk1 promotes ICER monoubiquitination and nuclear delocalization.
Mémin E, Genzale M, Crow M, Molina CA
Exp Cell Res. 2011
PubMed ID: 21767532
Cdk1 and BRCA1 target γ-tubulin to microtubule domains.
Hubert T, Vandekerckhove J, Gettemans J
Biochem Biophys Res Commun. 2011
PubMed ID: 21951856
DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells.
Zhang W, Peng G, Lin SY, Zhang P
J Biol Chem. 2011
PubMed ID: 21878640
NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.
Mori T, Ikeda DD, Fukushima T, Takenoshita S, Kochi H
Cell Cycle. 2011
PubMed ID: 21952639
Protein phosphatase 2A (B55α) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation.
Alvarez-Fernández M, Halim VA, Aprelia M, Laoukili J, Mohammed S, Medema RH
J Biol Chem. 2011
PubMed ID: 21813648
Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.
Berndt JD, Aoyagi A, Yang P, Anastas JN, Tang L, Moon RT
J Cell Biol. 2011
PubMed ID: 21875946
NF-Y binds to both G1- and G2-specific cyclin promoters; a possible role in linking CDK2/Cyclin A to CDK1/Cyclin B.
Chae HD, Kim J, Shin DY
BMB Rep. 2011
PubMed ID: 21871181
Ribosomal protein S3 is phosphorylated by Cdk1/cdc2 during G2/M phase.
Yoon IS, Chung JH, Hahm SH, Park MJ, Lee YR, Ko SI, Kang LW, Kim TS, Kim J, Han YS
BMB Rep. 2011
PubMed ID: 21871177
Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability.
Gao YF, Li T, Chang Y, Wang YB, Zhang WN, Li WH, He K, Mu R, Zhen C, Man JH, Pan X, Li T, Chen L, Yu M, Liang B, Chen Y, Xia Q, Zhou T, Gong WL, Li AL, Li HY, Zhang XM
Nat Cell Biol. 2011
PubMed ID: 21743465
VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling.
Passemard S, El Ghouzzi V, Nasser H, Verney C, Vodjdani G, Lacaud A, Lebon S, Laburthe M, Robberecht P, Nardelli J, Mani S, Verloes A, Gressens P, Lelièvre V
J Clin Invest. 2011
PubMed ID: 21737879
Human herpesvirus 6 suppresses T cell proliferation through induction of cell cycle arrest in infected cells in the G2/M phase.
Li L, Gu B, Zhou F, Chi J, Wang F, Peng G, Xie F, Qing J, Feng D, Lu S, Yao K
J Virol. 2011
PubMed ID: 21525341
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Cdc2: a monopotent or pluripotent CDK?
Hu X, Moscinski LC
Cell Prolif. 2011
PubMed ID: 21535261
Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1.
Smith E, Hégarat N, Vesely C, Roseboom I, Larch C, Streicher H, Straatman K, Flynn H, Skehel M, Hirota T, Kuriyama R, Hochegger H
EMBO J. 2011
PubMed ID: 21522128
Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip.
Machold R, Klein C, Fishell G
Gene Expr Patterns. 2011
PubMed ID: 21440680
Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases.
Moshe Y, Bar-On O, Ganoth D, Hershko A
J Biol Chem. 2011
PubMed ID: 21454540
A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets.
Castro DS, Martynoga B, Parras C, Ramesh V, Pacary E, Johnston C, Drechsel D, Lebel-Potter M, Garcia LG, Hunt C, Dolle D, Bithell A, Ettwiller L, Buckley N, Guillemot F
Genes Dev. 2011
PubMed ID: 21536733
Overexpressions of Cyclin B1, cdc2, p16 and p53 in human breast cancer: the clinicopathologic correlations and prognostic implications.
Chae SW, Sohn JH, Kim DH, Choi YJ, Park YL, Kim K, Cho YH, Pyo JS, Kim JH
Yonsei Med J. 2011
PubMed ID: 21488187
Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes.
Oh JS, Susor A, Conti M
Science. 2011
PubMed ID: 21454751
The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II.
Abe S, Nagasaka K, Hirayama Y, Kozuka-Hata H, Oyama M, Aoyagi Y, Obuse C, Hirota T
Genes Dev. 2011
PubMed ID: 21498573
Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited.
Potapova TA, Sivakumar S, Flynn JN, Li R, Gorbsky GJ
Mol Biol Cell. 2011
PubMed ID: 21325631
Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressor.
Hattori H, Skoulidis F, Russell P, Venkitaraman AR
Mol Cancer Ther. 2011
PubMed ID: 21289082
Inhibitory phosphorylation of cyclin-dependent kinase 1 as a compensatory mechanism for mitosis exit.
Chow JP, Poon RY, Ma HT
Mol Cell Biol. 2011
PubMed ID: 21262764
Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance.
Löffler H, Fechter A, Matuszewska M, Saffrich R, Mistrik M, Marhold J, Hornung C, Westermann F, Bartek J, Krämer A
Cancer Res. 2011
PubMed ID: 21406398
Cdk1 is required for the self-renewal of mouse embryonic stem cells.
Zhang WW, Zhang XJ, Liu HX, Chen J, Ren YH, Huang DG, Zou XH, Xiao W
J Cell Biochem. 2011
PubMed ID: 21328468
Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic.
Avdic V, Zhang P, Lanouette S, Voronova A, Skerjanc I, Couture JF
FASEB J. 2011
PubMed ID: 21135039
Cyclin-dependent kinase-mediated phosphorylation of RBP1 and pRb promotes their dissociation to mediate release of the SAP30·mSin3·HDAC transcriptional repressor complex.
Suryadinata R, Sadowski M, Steel R, Sarcevic B
J Biol Chem. 2011
PubMed ID: 21148318
Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
Greco TM, Yu F, Guise AJ, Cristea IM
Mol Cell Proteomics. 2011
PubMed ID: 21081666
Phosphorylation of phosphatidate phosphatase regulates its membrane association and physiological functions in Saccharomyces cerevisiae: identification of SER(602), THR(723), AND SER(744) as the sites phosphorylated by CDC28 (CDK1)-encoded cyclin-dependen
Choi HS, Su WM, Morgan JM, Han GS, Xu Z, Karanasios E, Siniossoglou S, Carman GM
J Biol Chem. 2011
PubMed ID: 21081492
Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.
Guo H, Friedman AD
J Biol Chem. 2011
PubMed ID: 21059642
Loss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistance.
Zhang C, Elkahloun AG, Robertson M, Gills JJ, Tsurutani J, Shih JH, Fukuoka J, Hollander MC, Harris CC, Travis WD, Jen J, Dennis PA
PLoS One. 2011
PubMed ID: 21887332
Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA
PLoS One. 2011
PubMed ID: 21731673
Cyclin B-dependent kinase 1 regulates human TRF1 to modulate the resolution of sister telomeres.
McKerlie M, Zhu XD
Nat Commun. 2011
PubMed ID: 21712819
Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer.
Medema RH, Macurek L
F1000 Biol Rep. 2011
PubMed ID: 21655336
Human immunodeficiency virus type 1 Vif causes dysfunction of Cdk1 and CyclinB1: implications for cell cycle arrest.
Sakai K, Barnitz RA, Chaigne-Delalande B, Bidère N, Lenardo MJ
Virol J. 2011
PubMed ID: 21569376
Cyclin dependent kinase 1 inhibitors: a review of recent progress.
Wang Q, Su L, Liu N, Zhang L, Xu W, Fang H
Curr Med Chem. 2011
PubMed ID: 21517772
Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP prostate cancer cells.
Chiu SC, Wang MJ, Yang HH, Chen SP, Huang SY, Chen YL, Lin SZ, Harn HJ, Pang CY
BMC Cancer. 2011
PubMed ID: 21504622
Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity.
Tumurbaatar I, Cizmecioglu O, Hoffmann I, Grummt I, Voit R
PLoS One. 2011
PubMed ID: 21379580
Initial characterization of the human central proteome.
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BMC Syst Biol. 2011
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
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PLoS Biol. 2011
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CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells.
Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC
Nat Cell Biol. 2011
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Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferation.
Linares JF, Amanchy R, Diaz-Meco MT, Moscat J
Mol Cell Biol. 2011
PubMed ID: 20974803
Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA.
Kaneko S, Li G, Son J, Xu CF, Margueron R, Neubert TA, Reinberg D
Genes Dev. 2010
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Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity.
Matthess Y, Raab M, Sanhaji M, Lavrik IN, Strebhardt K
Mol Cell Biol. 2010
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Cdc2/cyclin B1 regulates centrosomal Nlp proteolysis and subcellular localization.
Zhao X, Jin S, Song Y, Zhan Q
Cancer Biol Ther. 2010
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Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase.
Yim H, Erikson RL
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21041660
Cell cycle-dependent regulation of the forkhead transcription factor FOXK2 by CDK·cyclin complexes.
Marais A, Ji Z, Child ES, Krause E, Mann DJ, Sharrocks AD
J Biol Chem. 2010
PubMed ID: 20810654
CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment.
Itoh G, Kanno SI, Uchida KS, Chiba S, Sugino S, Watanabe K, Mizuno K, Yasui A, Hirota T, Tanaka K
EMBO J. 2010
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Revolving movement of a dynamic cluster of actin filaments during mitosis.
Mitsushima M, Aoki K, Ebisuya M, Matsumura S, Yamamoto T, Matsuda M, Toyoshima F, Nishida E
J Cell Biol. 2010
PubMed ID: 20974812
Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2.
Chen S, Bohrer LR, Rai AN, Pan Y, Gan L, Zhou X, Bagchi A, Simon JA, Huang H
Nat Cell Biol. 2010
PubMed ID: 20935635
An IGF1/insulin receptor substrate-1 pathway stimulates a mitotic kinase (cdk1) in the uterine epithelium during the proliferative response to estradiol.
Walker MP, Diaugustine RP, Zeringue E, Bunger MK, Schmitt M, Archer TK, Richards RG
J Endocrinol. 2010
PubMed ID: 20798132
Hyperphosphorylation by cyclin B/CDK1 in mitosis resets CUX1 DNA binding clock at each cell cycle.
Sansregret L, Gallo D, Santaguida M, Leduy L, Harada R, Nepveu A
J Biol Chem. 2010
PubMed ID: 20729212
Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.
Tsukahara T, Tanno Y, Watanabe Y
Nature. 2010
PubMed ID: 20739936
Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase.
Maeshima K, Iino H, Hihara S, Funakoshi T, Watanabe A, Nishimura M, Nakatomi R, Yahata K, Imamoto F, Hashikawa T, Yokota H, Imamoto N
Nat Struct Mol Biol. 2010
PubMed ID: 20711190
The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit.
van Zon W, Ogink J, ter Riet B, Medema RH, te Riele H, Wolthuis RM
J Cell Biol. 2010
PubMed ID: 20733055
Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.
Harley ME, Allan LA, Sanderson HS, Clarke PR
EMBO J. 2010
PubMed ID: 20526282
Cdk1 activity is required for mitotic activation of aurora A during G2/M transition of human cells.
Van Horn RD, Chu S, Fan L, Yin T, Du J, Beckmann R, Mader M, Zhu G, Toth J, Blanchard K, Ye XS
J Biol Chem. 2010
PubMed ID: 20444701
Phosphorylation of mixed lineage leukemia 5 by CDC2 affects its cellular distribution and is required for mitotic entry.
Liu J, Wang XN, Cheng F, Liou YC, Deng LW
J Biol Chem. 2010
PubMed ID: 20439461
The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development.
Risley MD, Clowes C, Yu M, Mitchell K, Hentges KE
Dev Biol. 2010
PubMed ID: 20347762
Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain.
Chou ST, Yen YC, Lee CM, Chen MS
J Biol Chem. 2010
PubMed ID: 20368335
Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1.
Alvarez-Fernández M, Halim VA, Krenning L, Aprelia M, Mohammed S, Heck AJ, Medema RH
EMBO Rep. 2010
PubMed ID: 20379221
Functional and spatial regulation of mitotic centromere-associated kinesin by cyclin-dependent kinase 1.
Sanhaji M, Friel CT, Kreis NN, Krämer A, Martin C, Howard J, Strebhardt K, Yuan J
Mol Cell Biol. 2010
PubMed ID: 20368358
Bortezomib potentially inhibits cellular growth of vascular endothelial cells through suppression of G2/M transition.
Tamura D, Arao T, Tanaka K, Kaneda H, Matsumoto K, Kudo K, Aomatsu K, Fujita Y, Watanabe T, Saijo N, Kotani Y, Nishimura Y, Nishio K
Cancer Sci. 2010
PubMed ID: 20367638
Centrosome-related genes, genetic variation, and risk of breast cancer.
Olson JE, Wang X, Pankratz VS, Fredericksen ZS, Vachon CM, Vierkant RA, Cerhan JR, Couch FJ
Breast Cancer Res Treat. 2010
PubMed ID: 20508983
Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.
Timofeev O, Cizmecioglu O, Settele F, Kempf T, Hoffmann I
J Biol Chem. 2010
PubMed ID: 20360007
New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses.
Yoon CH, Miah MA, Kim KP, Bae YS
EMBO Rep. 2010
PubMed ID: 20395957
Downregulation of Cdc2/CDK1 kinase activity induces the synthesis of noninfectious human papillomavirus type 31b virions in organotypic tissues exposed to benzo[a]pyrene.
Alam S, Bowser BS, Conway MJ, Israr M, Ryndock EJ, Xi LF, Meyers C
J Virol. 2010
PubMed ID: 20181698
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis.
Gavet O, Pines J
Dev Cell. 2010
PubMed ID: 20412769
Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis.
Gavet O, Pines J
J Cell Biol. 2010
PubMed ID: 20404109
An Oct4-centered protein interaction network in embryonic stem cells.
van den Berg DL, Snoek T, Mullin NP, Yates A, Bezstarosti K, Demmers J, Chambers I, Poot RA
Cell Stem Cell. 2010
PubMed ID: 20362541
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.
Pereg Y, Liu BY, O'Rourke KM, Sagolla M, Dey A, Komuves L, French DM, Dixit VM
Nat Cell Biol. 2010
PubMed ID: 20228808
Impact of Cyclin B2 and Cell division cycle 2 on tubular hyperplasia in progressive chronic renal failure rats.
Nishihara K, Masuda S, Nakagawa S, Yonezawa A, Ichimura T, Bonventre JV, Inui K
Am J Physiol Renal Physiol. 2010
PubMed ID: 20071461
Mitotic phosphorylation of Aki1 at Ser208 by cyclin B1-Cdk1 complex.
Nakamura A, Naito M, Arai H, Fujita N
Biochem Biophys Res Commun. 2010
PubMed ID: 20171170
SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition.
Kim JA, Lee J, Margolis RL, Fotedar R
Oncogene. 2010
PubMed ID: 20062077
Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis.
Terrano DT, Upreti M, Chambers TC
Mol Cell Biol. 2010
PubMed ID: 19917720
The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint.
LaGory EL, Sitailo LA, Denning MF
J Biol Chem. 2010
PubMed ID: 19917613
Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response.
Nantajit D, Fan M, Duru N, Wen Y, Reed JC, Li JJ
PLoS One. 2010
PubMed ID: 20808790
Raptor is phosphorylated by cdc2 during mitosis.
Gwinn DM, Asara JM, Shaw RJ
PLoS One. 2010
PubMed ID: 20169205
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M
Sci Signal. 2010
PubMed ID: 20068231
Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis.
Wang Z, Udeshi ND, Slawson C, Compton PD, Sakabe K, Cheung WD, Shabanowitz J, Hunt DF, Hart GW
Sci Signal. 2010
PubMed ID: 20068230
CKS proteins protect mitochondrial genome integrity by interacting with mitochondrial single-stranded DNA-binding protein.
Radulovic M, Crane E, Crawford M, Godovac-Zimmermann J, Yu VP
Mol Cell Proteomics. 2010
PubMed ID: 19786724
Variation in genes required for normal mitosis and risk of breast cancer.
Olson JE, Wang X, Goode EL, Pankratz VS, Fredericksen ZS, Vierkant RA, Pharoah PD, Cerhan JR, Couch FJ
Breast Cancer Res Treat. 2010
PubMed ID: 19377877
Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during G2/M transition.
Enomoto M, Goto H, Tomono Y, Kasahara K, Tsujimura K, Kiyono T, Inagaki M
J Biol Chem. 2009
PubMed ID: 19837665
Characterization of p70 S6 kinase 1 in early development of mouse embryos.
Xu XY, Zhang Z, Su WH, Zhang Y, Yu YQ, Li YX, Zong ZH, Yu BZ
Dev Dyn. 2009
PubMed ID: 19877273
Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis.
Ma HT, Tsang YH, Marxer M, Poon RY
Mol Cell Biol. 2009
PubMed ID: 19822658
Cyclin-dependent kinase 1 plays a critical role in DNA replication control during rat liver regeneration.
Garnier D, Loyer P, Ribault C, Guguen-Guillouzo C, Corlu A
Hepatology. 2009
PubMed ID: 19821535
Aging alters histone H4 acetylation and CDC2A in mouse germinal vesicle stage oocytes.
Manosalva I, González A
Biol Reprod. 2009
PubMed ID: 19641176
Cyclin-dependent kinases: a family portrait.
Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ
Nat Cell Biol. 2009
PubMed ID: 19884882
A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1.
Chen YJ, Dominguez-Brauer C, Wang Z, Asara JM, Costa RH, Tyner AL, Lau LF, Raychaudhuri P
J Biol Chem. 2009
PubMed ID: 19737929
Cdc2-mediated phosphorylation of CLIP-170 is essential for its inhibition of centrosome reduplication.
Yang X, Li H, Liu XS, Deng A, Liu X
J Biol Chem. 2009
PubMed ID: 19687009
Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis.
Singhal SS, Yadav S, Vatsyayan R, Chaudhary P, Borvak J, Singhal J, Awasthi S
Cancer Lett. 2009
PubMed ID: 19375851
A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.
Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD
Postgrad Med J. 2009
PubMed ID: 19789190
LIN54 is an essential core subunit of the DREAM/LINC complex that binds to the cdc2 promoter in a sequence-specific manner.
Schmit F, Cremer S, Gaubatz S
FEBS J. 2009
PubMed ID: 19725879
Linker histones stimulate HSPA2 atpase activity through NASP binding and inhibit CDC2/Cyclin B1 complex formation during meiosis in the mouse.
Alekseev OM, Richardson RT, O'Rand MG
Biol Reprod. 2009
PubMed ID: 19553603
Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases.
Yalcin A, Clem BF, Simmons A, Lane A, Nelson K, Clem AL, Brock E, Siow D, Wattenberg B, Telang S, Chesney J
J Biol Chem. 2009
PubMed ID: 19473963
A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286.
Pizarro JG, Folch J, Esparza JL, Jordan J, Pallàs M, Camins A
J Cell Mol Med. 2009
PubMed ID: 18624766
Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage.
Johnson N, Cai D, Kennedy RD, Pathania S, Arora M, Li YC, D'Andrea AD, Parvin JD, Shapiro GI
Mol Cell. 2009
PubMed ID: 19683496
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Selective cyclin-dependent kinase inhibitors discriminating between cell cycle and transcriptional kinases: future reality or utopia?
Wesierska-Gadek J, Krystof V
Ann N Y Acad Sci. 2009
PubMed ID: 19723060
Shengmai-san-mediated enhancement of regenerative responses of spinal cord axons after injury in rats.
Seo TB, Baek K, Kwon KB, Lee SI, Lim JS, Seol IC, Kim YS, Seo YB, Namgung U
J Pharmacol Sci. 2009
PubMed ID: 19672039
[Expression and significance of P53, P21WAF1 and CDK1 proteins in epithelial ovarian cancer].
Shi HR, Zhang RT
Ai Zheng. 2009
PubMed ID: 19664338
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG, Smith RD, Wiley HS, Qian WJ
J Proteome Res. 2009
PubMed ID: 19534553
Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.
Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, Kondratiuk I, Silver DP, Wolgemuth DJ, Akashi K, Sicinski P
Cell. 2009
PubMed ID: 19592082
Degradation of cyclin A is regulated by acetylation.
Mateo F, Vidal-Laliena M, Canela N, Busino L, Martinez-Balbas MA, Pagano M, Agell N, Bachs O
Oncogene. 2009
PubMed ID: 19483727
Modification of dietary copper levels on the early stage of tumor-promotion with propylthiouracil in a rat two-stage thyroid carcinogenesis model.
Shima T, Nishimura J, Dewa Y, Saegusa Y, Matsumoto S, Kawai M, Harada T, Mitsumori K, Shibutani M
Chem Biol Interact. 2009
PubMed ID: 19497425
Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome.
Zhang X, Chen Q, Feng J, Hou J, Yang F, Liu J, Jiang Q, Zhang C
J Cell Sci. 2009
PubMed ID: 19509060
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
Cdk1-cyclin B1-mediated phosphorylation of tumor-associated microtubule-associated protein/cytoskeleton-associated protein 2 in mitosis.
Hong KU, Kim HJ, Kim HS, Seong YS, Hong KM, Bae CD, Park J
J Biol Chem. 2009
PubMed ID: 19369249
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Cdc2 as prognostic marker in stage UICC II colon carcinomas.
Meyer A, Merkel S, Brückl W, Schellerer V, Schildberg C, Campean V, Hohenberger W, Croner RS
Eur J Cancer. 2009
PubMed ID: 19223178
Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC.
Calvisi DF, Pinna F, Ladu S, Pellegrino R, Simile MM, Frau M, De Miglio MR, Tomasi ML, Sanna V, Muroni MR, Feo F, Pascale RM
Gut. 2009
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Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ
Mol Cell Proteomics. 2009
PubMed ID: 19131326
The decision to enter mitosis: feedback and redundancy in the mitotic entry network.
Lindqvist A, Rodríguez-Bravo V, Medema RH
J Cell Biol. 2009
PubMed ID: 19364923
Cdk1 negatively regulates midzone localization of the mitotic kinesin Mklp2 and the chromosomal passenger complex.
Hümmer S, Mayer TU
Curr Biol. 2009
PubMed ID: 19303298
Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model.
Woo GH, Takahashi M, Inoue K, Fujimoto H, Igarashi K, Kanno J, Hirose M, Nishikawa A, Shibutani M
Cancer Sci. 2009
PubMed ID: 19298605
Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity.
Adler M, Müller K, Rached E, Dekant W, Mally A
Carcinogenesis. 2009
PubMed ID: 19237604
Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro.
Horiike Y, Kobayashi H, Sekiguchi T
Mol Biol Rep. 2009
PubMed ID: 18568422
Cyclin A-Cdk1 regulates the origin firing program in mammalian cells.
Katsuno Y, Suzuki A, Sugimura K, Okumura K, Zineldeen DH, Shimada M, Niida H, Mizuno T, Hanaoka F, Nakanishi M
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19221029
Cell cycle, CDKs and cancer: a changing paradigm.
Malumbres M, Barbacid M
Nat Rev Cancer. 2009
PubMed ID: 19238148
Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit.
Potapova TA, Daum JR, Byrd KS, Gorbsky GJ
Mol Biol Cell. 2009
PubMed ID: 19158392
EBV-encoded LMP1 regulates Op18/stathmin signaling pathway by cdc2 mediation in nasopharyngeal carcinoma cells.
Lin X, Liu S, Luo X, Ma X, Guo L, Li L, Li Z, Tao Y, Cao Y
Int J Cancer. 2009
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Cyclin C and cyclin dependent kinases 1, 2 and 3 in thrombin-induced neuronal cell cycle progression and apoptosis.
Rao HV, Thirumangalakudi L, Grammas P
Neurosci Lett. 2009
PubMed ID: 19103257
Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G1/S transition.
Li W, Kotoshiba S, Berthet C, Hilton MB, Kaldis P
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19129496
Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice.
Wang X, Rao RP, Kosakowska-Cholody T, Masood MA, Southon E, Zhang H, Berthet C, Nagashim K, Veenstra TK, Tessarollo L, Acharya U, Acharya JK
J Cell Biol. 2009
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Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
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Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm.
Melnick M, Phair RD, Lapidot SA, Jaskoll T
BMC Dev Biol. 2009
PubMed ID: 19500387
In vitro nuclear interactome of the HIV-1 Tat protein.
Gautier VW, Gu L, O'Donoghue N, Pennington S, Sheehy N, Hall WW
Retrovirology. 2009
PubMed ID: 19454010
Prediction of paclitaxel sensitivity by CDK1 and CDK2 activity in human breast cancer cells.
Nakayama S, Torikoshi Y, Takahashi T, Yoshida T, Sudo T, Matsushima T, Kawasaki Y, Katayama A, Gohda K, Hortobagyi GN, Noguchi S, Sakai T, Ishihara H, Ueno NT
Breast Cancer Res. 2009
PubMed ID: 19239702
The phagosomal proteome in interferon-gamma-activated macrophages.
Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P
Immunity. 2009
PubMed ID: 19144319
CDK phosphorylation of the discs large tumour suppressor controls its localisation and stability.
Narayan N, Massimi P, Banks L
J Cell Sci. 2009
PubMed ID: 19066288
Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells.
Merrick KA, Larochelle S, Zhang C, Allen JJ, Shokat KM, Fisher RP
Mol Cell. 2008
PubMed ID: 19061641
[Molecules of G(2)/M phase and the phosphorylation of survivin in the carcinogenesis of oral submucosal fibrosis].
Zhou SH, Li LL, Jian XC, Wang Y, Chen XQ, Gao X
Zhonghua Kou Qiang Yi Xue Za Zhi. 2008
PubMed ID: 19134343
Cyclin-dependent kinase 1/cyclin B1 phosphorylates varicella-zoster virus IE62 and is incorporated into virions.
Leisenfelder SA, Kinchington PR, Moffat JF
J Virol. 2008
PubMed ID: 18799590
Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity.
Ullah Z, Kohn MJ, Yagi R, Vassilev LT, DePamphilis ML
Genes Dev. 2008
PubMed ID: 18981479
Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: A two-stage Spanish case-control study.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A
Gynecol Oncol. 2008
PubMed ID: 18950845
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2.
Satyanarayana A, Berthet C, Lopez-Molina J, Coppola V, Tessarollo L, Kaldis P
Development. 2008
PubMed ID: 18787066
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
CDC2A (CDK1)-mediated phosphorylation of MSY2 triggers maternal mRNA degradation during mouse oocyte maturation.
Medvedev S, Yang J, Hecht NB, Schultz RM
Dev Biol. 2008
PubMed ID: 18606161
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor.
Liu P, Kao TP, Huang H
Oncogene. 2008
PubMed ID: 18408765
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.
Tang W, Wu JQ, Guo Y, Hansen DV, Perry JA, Freel CD, Nutt L, Jackson PK, Kornbluth S
Mol Biol Cell. 2008
PubMed ID: 18550795
Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF.
Pomerening JR, Ubersax JA, Ferrell JE
Mol Biol Cell. 2008
PubMed ID: 18480403
Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events.
De Boer L, Oakes V, Beamish H, Giles N, Stevens F, Somodevilla-Torres M, Desouza C, Gabrielli B
Oncogene. 2008
PubMed ID: 18372919
Cyclin A-CDK activity during G1 phase impairs MCM chromatin loading and inhibits DNA synthesis in mammalian cells.
Wheeler LW, Lents NH, Baldassare JJ
Cell Cycle. 2008
PubMed ID: 18635963
Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells.
Tan F, Lu L, Cai Y, Wang J, Xie Y, Wang L, Gong Y, Xu BE, Wu J, Luo Y, Qiang B, Yuan J, Sun X, Peng X
Proteomics. 2008
PubMed ID: 18655026
Nuclear HuR accumulation through phosphorylation by Cdk1.
Kim HH, Abdelmohsen K, Lal A, Pullmann R, Yang X, Galban S, Srikantan S, Martindale JL, Blethrow J, Shokat KM, Gorospe M
Genes Dev. 2008
PubMed ID: 18593881
Phosphorylation of threonine 61 by cyclin a/Cdk1 triggers degradation of stem-loop binding protein at the end of S phase.
Koseoglu MM, Graves LM, Marzluff WF
Mol Cell Biol. 2008
PubMed ID: 18490441
A novel role for Cdk1/cyclin B in regulating B-raf activation at mitosis.
Borysov SI, Guadagno TM
Mol Biol Cell. 2008
PubMed ID: 18434602
Involvement of the role of Chk1 in lithium-induced G2/M phase cell cycle arrest in hepatocellular carcinoma cells.
Wang XM, Li J, Feng XC, Wang Q, Guan DY, Shen ZH
J Cell Biochem. 2008
PubMed ID: 18247328
Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry.
Forsman A, Rüetschi U, Ekholm J, Rymo L
J Proteome Res. 2008
PubMed ID: 18457437
The anti-apoptosis protein, survivin, mediates gastric epithelial cell cytoprotection against ethanol-induced injury via activation of the p34(cdc2) cyclin-dependent kinase.
Jones MK, Padilla OR, Webb NA, Norng M
J Cell Physiol. 2008
PubMed ID: 18181150
DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis.
Marash L, Liberman N, Henis-Korenblit S, Sivan G, Reem E, Elroy-Stein O, Kimchi A
Mol Cell. 2008
PubMed ID: 18450493
TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells.
Pan J, Zou J, Wu DY, Roberson RS, Hennings LJ, Ma X, Yared M, Blackburn ML, Chansky HA, Yang L
Mol Cancer Res. 2008
PubMed ID: 18505930
Transient suppression of nuclear Cdc2 activity in response to ionizing radiation.
Kim MJ, Lee JY, Lee SJ
Oncol Rep. 2008
PubMed ID: 18425394
Dynamic expression of the RNA-binding protein Sam68 during mouse pre-implantation development.
Paronetto MP, Bianchi E, Geremia R, Sette C
Gene Expr Patterns. 2008
PubMed ID: 18321792
Changes in gene expression induced by chemoradiation in advanced cervical carcinoma: a microarray study of RTOG C-0128.
Zempolich K, Fuhrman C, Milash B, Flinner R, Greven K, Ryu J, Forbes A, Kerlin K, Nichols RC, Gaffney DK
Gynecol Oncol. 2008
PubMed ID: 18299147
Role of cellular phosphatase cdc25C in herpes simplex virus 1 replication.
Smith-Donald BA, Durand LO, Roizman B
J Virol. 2008
PubMed ID: 18272575
The interaction of herpes simplex virus 1 regulatory protein ICP22 with the cdc25C phosphatase is enabled in vitro by viral protein kinases US3 and UL13.
Smith-Donald BA, Roizman B
J Virol. 2008
PubMed ID: 18272572
cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner.
Smith EM, Proud CG
EMBO J. 2008
PubMed ID: 18337751
Phosphoregulation of MgcRacGAP in mitosis involves Aurora B and Cdk1 protein kinases and the PP2A phosphatase.
Touré A, Mzali R, Liot C, Seguin L, Morin L, Crouin C, Chen-Yang I, Tsay YG, Dorseuil O, Gacon G, Bertoglio J
FEBS Lett. 2008
PubMed ID: 18201571
Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator.
Voong LN, Slater AR, Kratovac S, Cressman DE
J Biol Chem. 2008
PubMed ID: 18245089
Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation.
Toyo-oka K, Mori D, Yano Y, Shiota M, Iwao H, Goto H, Inagaki M, Hiraiwa N, Muramatsu M, Wynshaw-Boris A, Yoshiki A, Hirotsune S
J Cell Biol. 2008
PubMed ID: 18347064
Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.
Yuan Z, Becker EB, Merlo P, Yamada T, DiBacco S, Konishi Y, Schaefer EM, Bonni A
Science. 2008
PubMed ID: 18356527
Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.
Pohl C, Jentsch S
Cell. 2008
PubMed ID: 18329369
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR
J Proteome Res. 2008
PubMed ID: 18220336
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Regulation of cAMP on the first mitotic cell cycle of mouse embryos.
Yu A, Zhang Z, Bi Q, Sun B, Su W, Guan Y, Mu R, Miao C, Zhang J, Yu B
Mol Reprod Dev. 2008
PubMed ID: 18022836
Development of a multiplex RNA urine test for the detection and stratification of transitional cell carcinoma of the bladder.
Holyoake A, O'Sullivan P, Pollock R, Best T, Watanabe J, Kajita Y, Matsui Y, Ito M, Nishiyama H, Kerr N, da Silva Tatley F, Cambridge L, Toro T, Ogawa O, Guilford P
Clin Cancer Res. 2008
PubMed ID: 18245534
Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis.
Chen Q, Zhang X, Jiang Q, Clarke PR, Zhang C
Cell Res. 2008
PubMed ID: 18195732
Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation.
Zhang L, Fried FB, Guo H, Friedman AD
Blood. 2008
PubMed ID: 18003885
Heat stress induces Cdc2 protein decrease prior to mouse spermatogenic cell apoptosis.
Zhang Y, Yang X, Cao H, Chen Z, Du Y, Kong W
Acta Histochem. 2008
PubMed ID: 18374969
Overexpression of CDC2/CyclinB1 in gliomas, and CDC2 depletion inhibits proliferation of human glioma cells in vitro and in vivo.
Chen H, Huang Q, Dong J, Zhai DZ, Wang AD, Lan Q
BMC Cancer. 2008
PubMed ID: 18230152
Determination of the specific activity of CDK1 and CDK2 as a novel prognostic indicator for early breast cancer.
Kim SJ, Nakayama S, Miyoshi Y, Taguchi T, Tamaki Y, Matsushima T, Torikoshi Y, Tanaka S, Yoshida T, Ishihara H, Noguchi S
Ann Oncol. 2008
PubMed ID: 17956886
p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint.
Satyanarayana A, Hilton MB, Kaldis P
Mol Biol Cell. 2008
PubMed ID: 17942597
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.
Forester CM, Maddox J, Louis JV, Goris J, Virshup DM
Proc Natl Acad Sci U S A. 2007
PubMed ID: 18056802
Cks1 regulates cdk1 expression: a novel role during mitotic entry in breast cancer cells.
Westbrook L, Manuvakhova M, Kern FG, Estes NR, Ramanathan HN, Thottassery JV
Cancer Res. 2007
PubMed ID: 18056467
Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity.
Zhang Q, Wang Y
J Proteome Res. 2007
PubMed ID: 17960875
Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed.
Skoufias DA, Indorato RL, Lacroix F, Panopoulos A, Margolis RL
J Cell Biol. 2007
PubMed ID: 18025303
Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
Cao L, Yu K, Banh C, Nguyen V, Ritz A, Raphael BJ, Kawakami Y, Kawakami T, Salomon AR
J Immunol. 2007
PubMed ID: 17947660
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD
J Proteome Res. 2007
PubMed ID: 17924679
Cell death in leukemia: passenger protein regulation by topoisomerase inhibitors.
Jahnke U, Higginbottom K, Newland AC, Cotter FE, Allen PD
Biochem Biophys Res Commun. 2007
PubMed ID: 17681274
New alternative phosphorylation sites on the cyclin dependent kinase 1/cyclin a complex in p53-deficient human cells treated with etoposide: possible association with etoposide-induced apoptosis.
Higginbottom K, Jahnke U, Newland AC, Cotter FE, Allen PD
Apoptosis. 2007
PubMed ID: 17636382
Polo-like kinase 1 may regulate G2/M transition of mouse fertilized eggs by means of inhibiting the phosphorylation of Tyr 15 of Cdc2.
Zhang Z, Su WH, Feng C, Yu DH, Cui C, Xu XY, Yu BZ
Mol Reprod Dev. 2007
PubMed ID: 17342725
Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.
Morgan AR, Turic D, Jehu L, Hamilton G, Hollingworth P, Moskvina V, Jones L, Lovestone S, Brayne C, Rubinsztein DC, Lawlor B, Gill M, O'Donovan MC, Owen MJ, Williams J
Am J Med Genet B Neuropsychiatr Genet. 2007
PubMed ID: 17373700
Cdk1 is sufficient to drive the mammalian cell cycle.
Santamaría D, Barrière C, Cerqueira A, Hunt S, Tardy C, Newton K, Cáceres JF, Dubus P, Malumbres M, Barbacid M
Nature. 2007
PubMed ID: 17700700
APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase.
Amador V, Ge S, Santamaría PG, Guardavaccaro D, Pagano M
Mol Cell. 2007
PubMed ID: 17679094
A differential phosphoproteomic analysis of retinoic acid-treated P19 cells.
Smith JC, Duchesne MA, Tozzi P, Ethier M, Figeys D
J Proteome Res. 2007
PubMed ID: 17622165
[CDK1 expression and effects of CDK1 silencing on the malignant phenotype of glioma cells]
Chen H, Huang Q, Zhai DZ, Dong J, Wang AD, Lan Q
Zhonghua Zhong Liu Za Zhi. 2007
PubMed ID: 18069625
Histone H1 and cdk1 kinase activities in early embryos of four mouse strains after X-irradiation.
Baatout S, Müller W, Michaux A, Buset J, Schoonjans W, Jacquet P
In Vivo. 2007
PubMed ID: 17708348
Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS.
Hester KD, Verhelle D, Escoubet-Lozach L, Luna R, Rose DW, Glass CK
Cell Cycle. 2007
PubMed ID: 17525531
Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice.
Raina K, Singh RP, Agarwal R, Agarwal C
Cancer Res. 2007
PubMed ID: 17575168
The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily.
Bosco P, Caraci F, Copani A, Spada RS, Sortino MA, Salluzzo R, Salemi M, Nicoletti F, Ferri R
Neurosci Lett. 2007
PubMed ID: 17498878
The tumor suppressor PP2A Abeta regulates the RalA GTPase.
Sablina AA, Chen W, Arroyo JD, Corral L, Hector M, Bulmer SE, DeCaprio JA, Hahn WC
Cell. 2007
PubMed ID: 17540176
Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.
Giorgianni F, Zhao Y, Desiderio DM, Beranova-Giorgianni S
Electrophoresis. 2007
PubMed ID: 17487921
GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases.
Birkenfeld J, Nalbant P, Bohl BP, Pertz O, Hahn KM, Bokoch GM
Dev Cell. 2007
PubMed ID: 17488622
Purvalanol A enhances cell killing by inhibiting up-regulation of CDC2 kinase activity in tumor cells irradiated with high doses of X rays.
Iizuka D, Inanami O, Kashiwakura I, Kuwabara M
Radiat Res. 2007
PubMed ID: 17474786
Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression.
Lindqvist A, van Zon W, Karlsson Rosenthal C, Wolthuis RM
PLoS Biol. 2007
PubMed ID: 17472438
G2/M checkpoint gene expression in developing germ cells.
Hasthorpe S, Tainton K, Peart M, Roeszler KN, Bell KM, Lusby PE, Hutson JM, Tymms MJ
Mol Reprod Dev. 2007
PubMed ID: 17290426
Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis.
Allan LA, Clarke PR
Mol Cell. 2007
PubMed ID: 17466630
Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells.
Rajgopal A, Young DW, Mujeeb KA, Stein JL, Lian JB, van Wijnen AJ, Stein GS
J Cell Biochem. 2007
PubMed ID: 17171635
Plant-derived MINA-05 inhibits human prostate cancer proliferation in vitro and lymph node spread in vivo.
Vandyke K, White MY, Nguyen-Khuong T, Ow K, Luk SC, Kingsley EA, Rowe A, Pang SF, Walsh BJ, Russell PJ
Neoplasia. 2007
PubMed ID: 17460776
Timing is everything: regulation of Cdk1 and aneuploidy.
Tsichlis PN, Hatziapostolou M, Hinds PW
Dev Cell. 2007
PubMed ID: 17419986
Mutational and expression analysis of CDK1, cyclinA2 and cyclinB1 in epilepsy-associated glioneuronal lesions.
Schick V, Majores M, Fassunke J, Engels G, Simon M, Elger CE, Becker AJ
Neuropathol Appl Neurobiol. 2007
PubMed ID: 17359356
Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1.
Neef R, Gruneberg U, Kopajtich R, Li X, Nigg EA, Sillje H, Barr FA
Nat Cell Biol. 2007
PubMed ID: 17351640
Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.
Geng L, Zhang X, Zheng S, Legerski RJ
Mol Cell Biol. 2007
PubMed ID: 17242184
Inhibition of CDC2/Cyclin B1 in response to selenium-induced oxidative stress during spermatogenesis: potential role of Cdc25c and p21.
Kaushal N, Bansal MP
Mol Cell Biochem. 2007
PubMed ID: 17160696
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.
Larochelle S, Merrick KA, Terret ME, Wohlbold L, Barboza NM, Zhang C, Shokat KM, Jallepalli PV, Fisher RP
Mol Cell. 2007
PubMed ID: 17386261
Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.
Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM
Cancer Cell. 2007
PubMed ID: 17349584
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
Flores-Delgado G, Liu CW, Sposto R, Berndt N
J Proteome Res. 2007
PubMed ID: 17274640
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H
Mol Cell Proteomics. 2007
PubMed ID: 17192257
Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells.
Yu J, Guo QL, You QD, Zhao L, Gu HY, Yang Y, Zhang HW, Tan Z, Wang X
Carcinogenesis. 2007
PubMed ID: 17012222
Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1.
Arai S, Miyake K, Voit R, Nemoto S, Wakeland EK, Grummt I, Miyazaki T
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17283331
TGFbeta regulates the expression and activities of G2 checkpoint kinases in human myeloid leukemia cells.
Hu X, Cui D, Moscinski LC, Zhang X, Maccachero V, Zuckerman KS
Cytokine. 2007
PubMed ID: 17459720
Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.
Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Mäkelä TP, Schneider MD
Cell Metab. 2007
PubMed ID: 17276355
Hydrogen peroxide impairs GRK2 translation via a calpain-dependent and cdk1-mediated pathway.
Cobelens PM, Kavelaars A, Heijnen CJ, Ribas C, Mayor F, Penela P
Cell Signal. 2007
PubMed ID: 16963227
Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
Cdc2-mediated Schwann cell migration during peripheral nerve regeneration.
Han IS, Seo TB, Kim KH, Yoon JH, Yoon SJ, Namgung U
J Cell Sci. 2007
PubMed ID: 17200138
Mip/LIN-9 regulates the expression of B-Myb and the induction of cyclin A, cyclin B, and CDK1.
Pilkinton M, Sandoval R, Song J, Ness SA, Colamonici OR
J Biol Chem. 2007
PubMed ID: 17098733
Role for non-proteolytic control of M-phase-promoting factor activity at M-phase exit.
D'Angiolella V, Palazzo L, Santarpia C, Costanzo V, Grieco D
PLoS One. 2007
PubMed ID: 17327911
Association analysis of genetic polymorphisms in the CDC2 gene with late-onset Alzheimer disease.
Liang X, Schnetz-Boutaud N, Bartlett J, Anderson BM, Gwirtsman H, Schmechel D, Carney R, Gilbert JR, Pericak-Vance MA, Haines JL
Dement Geriatr Cogn Disord. 2007
PubMed ID: 17159347
Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology.
Shimizu S, Khan MZ, Hippensteel RL, Parkar A, Raghupathi R, Meucci O
Neurobiol Dis. 2007
PubMed ID: 17011204
Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320.
Esteban V, Vázquez-Novelle MD, Calvo E, Bueno A, Sacristán MP
Cell Cycle. 2006
PubMed ID: 17172867
HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer.
Lokeshwar VB, Estrella V, Lopez L, Kramer M, Gomez P, Soloway MS, Lokeshwar BL
Cancer Res. 2006
PubMed ID: 17145867
Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation.
Panić L, Tamarut S, Sticker-Jantscheff M, Barkić M, Solter D, Uzelac M, Grabusić K, Volarević S
Mol Cell Biol. 2006
PubMed ID: 17000767
A protein interaction network for pluripotency of embryonic stem cells.
Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, Orkin SH
Nature. 2006
PubMed ID: 17093407
Necdin downregulates CDC2 expression to attenuate neuronal apoptosis.
Kurita M, Kuwajima T, Nishimura I, Yoshikawa K
J Neurosci. 2006
PubMed ID: 17108174
Unscheduled CDK1 activity in G1 phase of the cell cycle triggers apoptosis in X-irradiated lymphocytic leukemia cells.
Wu J, Feng Y, Xie D, Li X, Xiao W, Tao D, Qin J, Hu J, Gardner K, Judge SI, Li QQ, Gong J
Cell Mol Life Sci. 2006
PubMed ID: 17013563
Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1.
Chen S, Xu Y, Yuan X, Bubley GJ, Balk SP
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17043241
Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation.
Hirohashi Y, Wang Q, Liu Q, Li B, Du X, Zhang H, Furuuchi K, Masuda K, Sato N, Greene MI
Oncogene. 2006
PubMed ID: 16682949
Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis.
Vagnarelli P, Hudson DF, Ribeiro SA, Trinkle-Mulcahy L, Spence JM, Lai F, Farr CJ, Lamond AI, Earnshaw WC
Nat Cell Biol. 2006
PubMed ID: 16998479
DNA damage-induced down-regulation of human Cdc25C and Cdc2 is mediated by cooperation between p53 and maintenance DNA (cytosine-5) methyltransferase 1.
Le Gac G, Estève PO, Ferec C, Pradhan S
J Biol Chem. 2006
PubMed ID: 16807237
Cdk1/cyclin B-mediated phosphorylation stabilizes SREBP1 during mitosis.
Bengoechea-Alonso MT, Ericsson J
Cell Cycle. 2006
PubMed ID: 16880739
The Bloom syndrome helicase is a substrate of the mitotic Cdc2 kinase.
Bayart E, Dutertre S, Jaulin C, Guo RB, Xi XG, Amor-Guéret M
Cell Cycle. 2006
PubMed ID: 16880735
Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1.
Qi W, Tang Z, Yu H
Mol Biol Cell. 2006
PubMed ID: 16760428
Phosphorylation of the Pro-X-Thr-Pro site in phosphatase inhibitor-2 by cyclin-dependent protein kinase during M-phase of the cell cycle.
Li M, Stefansson B, Wang W, Schaefer EM, Brautigan DL
Cell Signal. 2006
PubMed ID: 16377132
Glyceraldehyde 3-phosphate dehydrogenase is a SET-binding protein and regulates cyclin B-cdk1 activity.
Carujo S, Estanyol JM, Ejarque A, Agell N, Bachs O, Pujol MJ
Oncogene. 2006
PubMed ID: 16474839
Cadmium induces cell cycle arrest in rat kidney epithelial cells in G2/M phase.
Xie J, Shaikh ZA
Toxicology. 2006
PubMed ID: 16730872
Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1.
Lee LT, Tan-Un KC, Chow BK
Ann N Y Acad Sci. 2006
PubMed ID: 16888198
Involvement of Cdc2 in axonal regeneration enhanced by exercise training in rats.
Seo TB, Han IS, Yoon JH, Hong KE, Yoon SJ, Namgung U
Med Sci Sports Exerc. 2006
PubMed ID: 16826023
Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation.
Berthet C, Klarmann KD, Hilton MB, Suh HC, Keller JR, Kiyokawa H, Kaldis P
Dev Cell. 2006
PubMed ID: 16678773
Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1).
Shiromizu T, Goto H, Tomono Y, Bartek J, Totsukawa G, Inoko A, Nakanishi M, Matsumura F, Inagaki M
Genes Cells. 2006
PubMed ID: 16629900
Phosphoproteome analysis of the human mitotic spindle.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16565220
The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.
Petretti C, Savoian M, Montembault E, Glover DM, Prigent C, Giet R
EMBO Rep. 2006
PubMed ID: 16462731
Modulation of cell-cycle regulatory signaling network by 2-methoxyestradiol in prostate cancer cells is mediated through multiple signal transduction pathways.
Ray G, Dhar G, Van Veldhuizen PJ, Banerjee S, Saxena NK, Sengupta K, Banerjee SK
Biochemistry. 2006
PubMed ID: 16533053
Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation.
Qiao M, Shapiro P, Fosbrink M, Rus H, Kumar R, Passaniti A
J Biol Chem. 2006
PubMed ID: 16407259
Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells.
Komamura-Kohno Y, Karasawa-Shimizu K, Saitoh T, Sato M, Hanaoka F, Tanaka S, Ishimi Y
FEBS J. 2006
PubMed ID: 16519687
Expression of cdc2 and p27(KIP1) phosphorylation in mitotic cells of the human retinoblastoma.
Kase S, Yoshida K, Ohgami K, Shiratori K, Suzuki Y, Nakayama KI, Ohno S
Int J Mol Med. 2006
PubMed ID: 16465393
Cell cycle and cell death regulation of neural progenitor cells in the 5-azacytidine (5AzC)-treated developing fetal brain.
Ueno M, Katayama K, Yamauchi H, Nakayama H, Doi K
Exp Neurol. 2006
PubMed ID: 16427046
Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1.
Fourest-Lieuvin A, Peris L, Gache V, Garcia-Saez I, Juillan-Binard C, Lantez V, Job D
Mol Biol Cell. 2006
PubMed ID: 16371510
Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20.
Shoji S, Yoshida N, Amanai M, Ohgishi M, Fukui T, Fujimoto S, Nakano Y, Kajikawa E, Perry AC
EMBO J. 2006
PubMed ID: 16456547
p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation.
Asefa B, Dermott JM, Kaldis P, Stefanisko K, Garfinkel DJ, Keller JR
FEBS Lett. 2006
PubMed ID: 16458891
Analysis on heat stress-induced hyperphosphorylation of stathmin at serine 37 in Jurkat cells by means of two-dimensional gel electrophoresis and tandem mass spectrometry.
Nakamura K, Zhang X, Kuramitsu Y, Fujimoto M, Yuan X, Akada J, Aoshima-Okuda M, Mitani N, Itoh Y, Katoh T, Morita Y, Nagasaka Y, Yamazaki Y, Kuriki T, Sobel A
J Chromatogr A. 2006
PubMed ID: 16427064
Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.
Niiya F, Tatsumoto T, Lee KS, Miki T
Oncogene. 2006
PubMed ID: 16247472
PKB/AKT is involved in resumption of meiosis in mouse oocytes.
Kalous J, Solc P, Baran V, Kubelka M, Schultz RM, Motlik J
Biol Cell. 2006
PubMed ID: 15842198
The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers.
Paulsen MT, Starks AM, Derheimer FA, Hanasoge S, Li L, Dixon JE, Ljungman M
Mol Cancer. 2006
PubMed ID: 16784539
Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity.
Kang J, Gocke CB, Yu H
BMC Biochem. 2006
PubMed ID: 16478538
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A
Am J Hum Genet. 2006
PubMed ID: 16385451
The LIFEdb database in 2006.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S
Nucleic Acids Res. 2006
PubMed ID: 16381901
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.
Niture SK, Doneanu CE, Velu CS, Bailey NI, Srivenugopal KS
Biochem Biophys Res Commun. 2005
PubMed ID: 16226712
Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe.
Niida H, Tsuge S, Katsuno Y, Konishi A, Takeda N, Nakanishi M
J Biol Chem. 2005
PubMed ID: 16159883
Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis.
Yamaguchi T, Goto H, Yokoyama T, Silljé H, Hanisch A, Uldschmid A, Takai Y, Oguri T, Nigg EA, Inagaki M
J Cell Biol. 2005
PubMed ID: 16260496
Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.
Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY
Cell Res. 2005
PubMed ID: 16354571
Cell cycle sibling rivalry: Cdc2 vs. Cdk2.
Kaldis P, Aleem E
Cell Cycle. 2005
PubMed ID: 16258277
Cdc2/cyclin B1 interacts with and modulates inositol 1,4,5-trisphosphate receptor (type 1) functions.
Malathi K, Li X, Krizanova O, Ondrias K, Sperber K, Ablamunits V, Jayaraman T
J Immunol. 2005
PubMed ID: 16237118
Mammalian cyclin-dependent kinases.
Malumbres M, Barbacid M
Trends Biochem Sci. 2005
PubMed ID: 16236519
Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner.
Niiya F, Xie X, Lee KS, Inoue H, Miki T
J Biol Chem. 2005
PubMed ID: 16118207
Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis.
Fabbro M, Zhou BB, Takahashi M, Sarcevic B, Lal P, Graham ME, Gabrielli BG, Robinson PJ, Nigg EA, Ono Y, Khanna KK
Dev Cell. 2005
PubMed ID: 16198290
Distinct roles for the mammalian A-type cyclins during oogenesis.
Persson JL, Zhang Q, Wang XY, Ravnik SE, Muhlrad S, Wolgemuth DJ
Reproduction. 2005
PubMed ID: 16183859
2-Chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU) exhibits p53-dependent and -independent antiproliferative activity in human nasopharyngeal carcinoma cells in vitro and in vivo.
Nguyen TH, Ong CK, Wong E, Leong CT, Panasci L, Huynh H
Int J Oncol. 2005
PubMed ID: 16142332
Differential regulation of CDP/Cux p110 by cyclin A/Cdk2 and cyclin A/Cdk1.
Santaguida M, Nepveu A
J Biol Chem. 2005
PubMed ID: 16081423
Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse.
Han SJ, Chen R, Paronetto MP, Conti M
Curr Biol. 2005
PubMed ID: 16169490
Cdc2 and Cdk2 play critical roles in low dose doxorubicin-induced cell death through mitotic catastrophe but not in high dose doxorubicin-induced apoptosis.
Park SS, Eom YW, Choi KS
Biochem Biophys Res Commun. 2005
PubMed ID: 16036217
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.
Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM
Mol Cell Proteomics. 2005
PubMed ID: 15951569
Cell cycle protein profile of the hepatic stellate cells(HSCs)in dimethylnitrosamine-induced rat hepatic fibrosis.
Kim MR, Kim HS, Lee MS, Lee MJ, Jang JJ
Exp Mol Med. 2005
PubMed ID: 16155410
Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation.
Nandan MO, Chanchevalap S, Dalton WB, Yang VW
FEBS Lett. 2005
PubMed ID: 16102754
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.
Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K
Mol Cell. 2005
PubMed ID: 16109376
Cdc2-cyclin E complexes regulate the G1/S phase transition.
Aleem E, Kiyokawa H, Kaldis P
Nat Cell Biol. 2005
PubMed ID: 16007079
Global phosphoproteome of HT-29 human colon adenocarcinoma cells.
Kim JE, Tannenbaum SR, White FM
J Proteome Res. 2005
PubMed ID: 16083285
Mutual inhibition of separase and Cdk1 by two-step complex formation.
Gorr IH, Boos D, Stemmann O
Mol Cell. 2005
PubMed ID: 15989971
Cdc2-mediated inhibition of epidermal growth factor activation of the extracellular signal-regulated kinase pathway during mitosis.
Dangi S, Shapiro P
J Biol Chem. 2005
PubMed ID: 15888452
3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues.
Loughney K, Taylor J, Florio VA
Int J Impot Res. 2005
PubMed ID: 15800651
Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint.
Jiang H, Luo S, Li H
J Biol Chem. 2005
PubMed ID: 15790566
Genomewide production of multipurpose alleles for the functional analysis of the mouse genome.
Schnütgen F, De-Zolt S, Van Sloun P, Hollatz M, Floss T, Hansen J, Altschmied J, Seisenberger C, Ghyselinck NB, Ruiz P, Chambon P, Wurst W, von Melchner H
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15870191
BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation.
Yan Y, Spieker RS, Kim M, Stoeger SM, Cowan KH
Oncogene. 2005
PubMed ID: 15735702
The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleus.
Summers MK, Bothos J, Halazonetis TD
Oncogene. 2005
PubMed ID: 15674323
Phosphorylation of MdmX by CDK2/Cdc2(p34) is required for nuclear export of Mdm2.
Elias B, Laine A, Ronai Z
Oncogene. 2005
PubMed ID: 15735705
HIV-1 viral protein R (Vpr) & host cellular responses.
Zhao RY, Bukrinsky M, Elder RT
Indian J Med Res. 2005
PubMed ID: 15817944
Human papillomavirus type 16 E1 E4-induced G2 arrest is associated with cytoplasmic retention of active Cdk1/cyclin B1 complexes.
Davy CE, Jackson DJ, Raj K, Peh WL, Southern SA, Das P, Sorathia R, Laskey P, Middleton K, Nakahara T, Wang Q, Masterson PJ, Lambert PF, Cuthill S, Millar JB, Doorbar J
J Virol. 2005
PubMed ID: 15767402
Blunted DNA synthesis and delayed S-phase entry following inhibition of Cdk2 activity in the regenerating rat liver.
Stärkel P, De Saeger C, Sempoux C, Legrand E, Leclercq I, Horsmans Y
Lab Invest. 2005
PubMed ID: 15696186
Functional interaction of Puralpha with the Cdk2 moiety of cyclin A/Cdk2.
Liu H, Barr SM, Chu C, Kohtz DS, Kinoshita Y, Johnson EM
Biochem Biophys Res Commun. 2005
PubMed ID: 15707957
The multifunctional nuclear protein p54nrb is multiphosphorylated in mitosis and interacts with the mitotic regulator Pin1.
Proteau A, Blier S, Albert AL, Lavoie SB, Traish AM, Vincent M
J Mol Biol. 2005
PubMed ID: 15701524
Viral infections and cell cycle G2/M regulation.
Zhao RY, Elder RT
Cell Res. 2005
PubMed ID: 15780175
Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression.
Li B, Nair M, Mackay DR, Bilanchone V, Hu M, Fallahi M, Song H, Dai Q, Cohen PE, Dai X
Development. 2005
PubMed ID: 15716349
Relationship between intracellular localization of p34cdc2 protein and differentiation of esophageal squamous cell carcinoma.
Nozoe T, Takahashi I, Baba H, Maehara Y
J Cancer Res Clin Oncol. 2005
PubMed ID: 15662526
p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity.
Normand G, Hemmati PG, Verdoodt B, von Haefen C, Wendt J, Güner D, May E, Dörken B, Daniel PT
J Biol Chem. 2005
PubMed ID: 15582998
Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling.
Preisinger C, Körner R, Wind M, Lehmann WD, Kopajtich R, Barr FA
EMBO J. 2005
PubMed ID: 15678101
Cell-cycle-dependent subcellular localization of cyclin B1, phosphorylated cyclin B1 and p34cdc2 during oocyte meiotic maturation and fertilization in mouse.
Huo LJ, Yu LZ, Liang CG, Fan HY, Chen DY, Sun QY
Zygote. 2005
PubMed ID: 15984162
Expression of cell cycle-related proteins in developing and adult mouse hippocampus.
Schmetsdorf S, Gärtner U, Arendt T
Int J Dev Neurosci. 2005
PubMed ID: 15730892
Contribution of high p34cdc2 kinase activity to premature chromosome condensation of injected somatic cell nuclei in rat oocytes.
Ito J, Hirabayashi M, Kato M, Takeuchi A, Ito M, Shimada M, Hochi S
Reproduction. 2005
PubMed ID: 15695611
Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP.
Kim EH, Kim SU, Choi KS
Oncogene. 2005
PubMed ID: 15531913
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease.
Johansson A, Zetterberg H, Hampel H, Buerger K, Prince JA, Minthon L, Wahlund LO, Blennow K
Dement Geriatr Cogn Disord. 2005
PubMed ID: 16192727
Induction of p21Cip1-mediated G2/M arrest in H2O2-treated lens epithelial cells.
Seomun Y, Kim JT, Kim HS, Park JY, Joo CK
Mol Vis. 2005
PubMed ID: 16179908
Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment.
Kim J, Bhinge AA, Morgan XC, Iyer VR
Nat Methods. 2005
PubMed ID: 15782160
The Vpr protein from HIV-1: distinct roles along the viral life cycle.
Le Rouzic E, Benichou S
Retrovirology. 2005
PubMed ID: 15725353
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ
Nat Biotechnol. 2005
PubMed ID: 15592455
Protein kinase A regulates cell cycle progression of mouse fertilized eggs by means of MPF.
Yu B, Wang Y, Liu Y, Liu Y, Li X, Wu D, Zong Z, Zhang J, Yu D
Dev Dyn. 2005
PubMed ID: 15580572
Mitotic regulation of protein 4.1R involves phosphorylation by cdc2 kinase.
Huang SC, Liu ES, Chan SH, Munagala ID, Cho HT, Jagadeeswaran R, Benz EJ
Mol Biol Cell. 2005
PubMed ID: 15525677
Characterization of a MAPKK-like protein kinase TOPK.
Matsumoto S, Abe Y, Fujibuchi T, Takeuchi T, Kito K, Ueda N, Shigemoto K, Gyo K
Biochem Biophys Res Commun. 2004
PubMed ID: 15541388
A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint.
Bayart E, Grigorieva O, Leibovitch S, Onclercq-Delic R, Amor-Guéret M
Cancer Res. 2004
PubMed ID: 15604258
Structure and function of HIV-1 auxiliary regulatory protein Vpr: novel clues to drug design.
Zhao LJ, Zhu H
Curr Drug Targets Immune Endocr Metabol Disord. 2004
PubMed ID: 15578977
The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis.
Krupczak-Hollis K, Wang X, Kalinichenko VV, Gusarova GA, Wang IC, Dennewitz MB, Yoder HM, Kiyokawa H, Kaestner KH, Costa RH
Dev Biol. 2004
PubMed ID: 15531365
Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1).
Göke R, Barth P, Schmidt A, Samans B, Lankat-Buttgereit B
Am J Physiol Cell Physiol. 2004
PubMed ID: 15317660
Molecular models of cyclin-dependent kinase 1 complexed with inhibitors.
Canduri F, Uchoa HB, de Azevedo WF
Biochem Biophys Res Commun. 2004
PubMed ID: 15474478
A common set of gene regulatory networks links metabolism and growth inhibition.
Cam H, Balciunaite E, Blais A, Spektor A, Scarpulla RC, Young R, Kluger Y, Dynlacht BD
Mol Cell. 2004
PubMed ID: 15525513
Abi enhances Abl-mediated CDC2 phosphorylation and inactivation.
Lin TY, Huang CH, Chou WG, Juang JL
J Biomed Sci. 2004
PubMed ID: 15591787
Phosphoproteomic analysis of the developing mouse brain.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP
Mol Cell Proteomics. 2004
PubMed ID: 15345747
From ORFeome to biology: a functional genomics pipeline.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A
Genome Res. 2004
PubMed ID: 15489336
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
FANCG is phosphorylated at serines 383 and 387 during mitosis.
Mi J, Qiao F, Wilson JB, High AA, Schroeder MJ, Stukenberg PT, Moss A, Shabanowitz J, Hunt DF, Jones NJ, Kupfer GM
Mol Cell Biol. 2004
PubMed ID: 15367677
Regulation of activation-induced Fas (CD95/Apo-1) ligand expression in T cells by the cyclin B1/Cdk1 complex.
Torgler R, Jakob S, Ontsouka E, Nachbur U, Mueller C, Green DR, Brunner T
J Biol Chem. 2004
PubMed ID: 15215233
Protein kinase B, P34cdc2 kinase, and p21 ras GTP-binding in kidneys of aging rats.
Parekh VV, Falcone JC, Wills-Frank LA, Joshua IG, Dholakia JN, Passmore JC
Exp Biol Med (Maywood). 2004
PubMed ID: 15337841
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase.
Krämer A, Mailand N, Lukas C, Syljuåsen RG, Wilkinson CJ, Nigg EA, Bartek J, Lukas J
Nat Cell Biol. 2004
PubMed ID: 15311285
Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes.
Bicknell KA, Coxon CH, Brooks G
Biochem J. 2004
PubMed ID: 15253691
p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress.
Charrier-Savournin FB, Château MT, Gire V, Sedivy J, Piette J, Dulic V
Mol Biol Cell. 2004
PubMed ID: 15181148
Gene expression analysis of the late embryonic mouse cerebral cortex using DNA microarray: identification of several region- and layer-specific genes.
Funatsu N, Inoue T, Nakamura S
Cereb Cortex. 2004
PubMed ID: 15142957
Mouse development and cell proliferation in the absence of D-cyclins.
Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K, Sicinski P
Cell. 2004
PubMed ID: 15315760
Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium.
Chaudhry HW, Dashoush NH, Tang H, Zhang L, Wang X, Wu EX, Wolgemuth DJ
J Biol Chem. 2004
PubMed ID: 15159393
Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease.
Toivola DM, Ku NO, Resurreccion EZ, Nelson DR, Wright TL, Omary MB
Hepatology. 2004
PubMed ID: 15368451
Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region.
Hsu JM, Lee YC, Yu CT, Huang CY
J Biol Chem. 2004
PubMed ID: 15145941
The Fanconi anemia core complex forms four complexes of different sizes in different subcellular compartments.
Thomashevski A, High AA, Drozd M, Shabanowitz J, Hunt DF, Grant PA, Kupfer GM
J Biol Chem. 2004
PubMed ID: 15082718
The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis.
Bukczynska P, Klingler-Hoffmann M, Mitchelhill KI, Lam MH, Ciccomancini M, Tonks NK, Sarcevic B, Kemp BE, Tiganis T
Biochem J. 2004
PubMed ID: 15030318
MD-2: the Toll 'gatekeeper' in endotoxin signalling.
Gangloff M, Gay NJ
Trends Biochem Sci. 2004
PubMed ID: 15276183
Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?
Kino T, Chrousos GP
Ann N Y Acad Sci. 2004
PubMed ID: 15265780
Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation.
Dai X, Yamasaki K, Yang L, Sayama K, Shirakata Y, Tokumara S, Yahata Y, Tohyama M, Hashimoto K
J Invest Dermatol. 2004
PubMed ID: 15175024
The DNA sequence and comparative analysis of human chromosome 10.
Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J
Nature. 2004
PubMed ID: 15164054
The human nuclear SRcyp is a cell cycle-regulated cyclophilin.
Dubourg B, Kamphausen T, Weiwad M, Jahreis G, Feunteun J, Fischer G, Modjtahedi N
J Biol Chem. 2004
PubMed ID: 15016823
Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion.
Litvak V, Argov R, Dahan N, Ramachandran S, Amarilio R, Shainskaya A, Lev S
Mol Cell. 2004
PubMed ID: 15125835
Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding.
Sugimoto N, Tatsumi Y, Tsurumi T, Matsukage A, Kiyono T, Nishitani H, Fujita M
J Biol Chem. 2004
PubMed ID: 14993212
Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma.
Shapira M, Ben-Izhak O, Bishara B, Futerman B, Minkov I, Krausz MM, Pagano M, Hershko DD
Cancer. 2004
PubMed ID: 15073847
Proliferation inhibition of astrocytes, neurons, and non-glial cells by intracellularly expressed human immunodeficiency virus type 1 (HIV-1) Tat protein.
Zhou BY, He JJ
Neurosci Lett. 2004
PubMed ID: 15050687
Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.
Kino T, Pavlakis GN
DNA Cell Biol. 2004
PubMed ID: 15142377
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
Genome Res. 2004
PubMed ID: 15060019
Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators.
Major ML, Lepe R, Costa RH
Mol Cell Biol. 2004
PubMed ID: 15024056
Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarrays.
Swierczynski SL, Maitra A, Abraham SC, Iacobuzio-Donahue CA, Ashfaq R, Cameron JL, Schulick RD, Yeo CJ, Rahman A, Hinkle DA, Hruban RH, Argani P
Hum Pathol. 2004
PubMed ID: 15017593
Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells.
Li HY, Zheng Y
Genes Dev. 2004
PubMed ID: 15014043
Mutant MyoD lacking Cdc2 phosphorylation sites delays M-phase entry.
Tintignac LA, Sirri V, Leibovitch MP, Lécluse Y, Castedo M, Metivier D, Kroemer G, Leibovitch SA
Mol Cell Biol. 2004
PubMed ID: 14749395
Perturbation of ATP-induced tetramerization of human cytosolic thymidine kinase by substitution of serine-13 with aspartic acid at the mitotic phosphorylation site.
Li CL, Lu CY, Ke PY, Chang ZF
Biochem Biophys Res Commun. 2004
PubMed ID: 14697231
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B.
Astrinidis A, Senapedis W, Coleman TR, Henske EP
J Biol Chem. 2003
PubMed ID: 14551205
Inositol 1,4,5-trisphosphate receptor (type 1) phosphorylation and modulation by Cdc2.
Malathi K, Kohyama S, Ho M, Soghoian D, Li X, Silane M, Berenstein A, Jayaraman T
J Cell Biochem. 2003
PubMed ID: 14635192
Mechanisms governing maintenance of Cdk1/cyclin B1 kinase activity in cells infected with human cytomegalovirus.
Sanchez V, McElroy AK, Spector DH
J Virol. 2003
PubMed ID: 14645578
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Cyclin-dependent kinase 1 gene expression is associated with poor prognosis in gastric carcinoma.
Masuda TA, Inoue H, Nishida K, Sonoda H, Yoshikawa Y, Kakeji Y, Utsunomiya T, Mori M
Clin Cancer Res. 2003
PubMed ID: 14654553
DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase.
Yuan L, Yu WM, Qu CK
J Biol Chem. 2003
PubMed ID: 12937170
Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.
Chow JP, Siu WY, Ho HT, Ma KH, Ho CC, Poon RY
J Biol Chem. 2003
PubMed ID: 12912980
Control mechanism of the circadian clock for timing of cell division in vivo.
Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, Okamura H
Science. 2003
PubMed ID: 12934012
Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.
Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA
Exp Cell Res. 2003
PubMed ID: 14499622
p34cdc2 expression is an independent indicator for lymph node metastasis in colorectal carcinoma.
Nozoe T, Honda M, Inutsuka S, Korenaga D
J Cancer Res Clin Oncol. 2003
PubMed ID: 12884029
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.
Rossé C, L'Hoste S, Offner N, Picard A, Camonis J
J Biol Chem. 2003
PubMed ID: 12775724
Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.
Gaiddon C, Lokshin M, Gross I, Levasseur D, Taya Y, Loeffler JP, Prives C
J Biol Chem. 2003
PubMed ID: 12676926
Cell cycle-dependent phosphorylation of Disabled-2 by cdc2.
He J, Xu J, Xu XX, Hall RA
Oncogene. 2003
PubMed ID: 12881709
A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5.
Yeo M, Lin PS, Dahmus ME, Gill GN
J Biol Chem. 2003
PubMed ID: 12721286
Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation.
Henneke G, Koundrioukoff S, Hübscher U
Oncogene. 2003
PubMed ID: 12853968
Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.
Casenghi M, Meraldi P, Weinhart U, Duncan PI, Körner R, Nigg EA
Dev Cell. 2003
PubMed ID: 12852856
A direct role for GRASP65 as a mitotically regulated Golgi stacking factor.
Wang Y, Seemann J, Pypaert M, Shorter J, Warren G
EMBO J. 2003
PubMed ID: 12839990
Cdk5 regulates the organization of Nestin and its association with p35.
Sahlgren CM, Mikhailov A, Vaittinen S, Pallari HM, Kalimo H, Pant HC, Eriksson JE
Mol Cell Biol. 2003
PubMed ID: 12832492
The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle.
Uchiyama K, Jokitalo E, Lindman M, Jackman M, Kano F, Murata M, Zhang X, Kondo H
J Cell Biol. 2003
PubMed ID: 12810701
Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.
Margottin-Goguet F, Hsu JY, Loktev A, Hsieh HM, Reimann JD, Jackson PK
Dev Cell. 2003
PubMed ID: 12791267
Upregulation of Cdc2 and cyclin A during apoptosis of endothelial cells induced by cleaved high-molecular-weight kininogen.
Wang S, Hasham MG, Isordia-Salas I, Tsygankov AY, Colman RW, Guo YL
Am J Physiol Heart Circ Physiol. 2003
PubMed ID: 12742823
Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration.
Manes T, Zheng DQ, Tognin S, Woodard AS, Marchisio PC, Languino LR
J Cell Biol. 2003
PubMed ID: 12771130
Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2.
Shah OJ, Ghosh S, Hunter T
J Biol Chem. 2003
PubMed ID: 12586835
Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.
Chikamori K, Grabowski DR, Kinter M, Willard BB, Yadav S, Aebersold RH, Bukowski RM, Hickson ID, Andersen AH, Ganapathi R, Ganapathi MK
J Biol Chem. 2003
PubMed ID: 12569090
Increased frequency of a new polymorphism in the cell division cycle 2 (cdc2) gene in patients with Alzheimer's disease and frontotemporal dementia.
Johansson A, Hampel H, Faltraco F, Buerger K, Minthon L, Bogdanovic N, Sjögren M, Zetterberg H, Forsell L, Lilius L, Wahlund LO, Rymo L, Prince JA, Blennow K
Neurosci Lett. 2003
PubMed ID: 12648761
Deregulation of Cdc2 kinase induces caspase-3 activation and apoptosis.
Gu L, Zheng H, Murray SA, Ying H, Jim Xiao ZX
Biochem Biophys Res Commun. 2003
PubMed ID: 12604359
Tip60 acetyltransferase activity is controlled by phosphorylation.
Lemercier C, Legube G, Caron C, Louwagie M, Garin J, Trouche D, Khochbin S
J Biol Chem. 2003
PubMed ID: 12468530
Overexpression of Cdc25B, an androgen receptor coactivator, in prostate cancer.
Ngan ES, Hashimoto Y, Ma ZQ, Tsai MJ, Tsai SY
Oncogene. 2003
PubMed ID: 12569365
Phosphorylation of the cyclin b1 cytoplasmic retention sequence by mitogen-activated protein kinase and Plx.
Walsh S, Margolis SS, Kornbluth S
Mol Cancer Res. 2003
PubMed ID: 12612056
Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.
Yan X, Li F, Liang Y, Shen Y, Zhao X, Huang Q, Zhu X
Mol Cell Biol. 2003
PubMed ID: 12556484
Conserved protein kinases encoded by herpesviruses and cellular protein kinase cdc2 target the same phosphorylation site in eukaryotic elongation factor 1delta.
Kawaguchi Y, Kato K, Tanaka M, Kanamori M, Nishiyama Y, Yamanashi Y
J Virol. 2003
PubMed ID: 12551973
Depletion of Wee-1 kinase is necessary for both human immunodeficiency virus type 1 Vpr- and gamma irradiation-induced apoptosis.
Yuan H, Xie YM, Chen IS
J Virol. 2003
PubMed ID: 12525641
The SET protein regulates G2/M transition by modulating cyclin B-cyclin-dependent kinase 1 activity.
Canela N, Rodriguez-Vilarrupla A, Estanyol JM, Diaz C, Pujol MJ, Agell N, Bachs O
J Biol Chem. 2003
PubMed ID: 12407107
Regulation of caldesmon activity by Cdc2 kinase plays an important role in maintaining membrane cortex integrity during cell division.
Li Y, Wessels D, Wang T, Lin JL, Soll DR, Lin JJ
Cell Mol Life Sci. 2003
PubMed ID: 12613668
A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression.
Nuthall HN, Joachim K, Palaparti A, Stifani S
J Biol Chem. 2002
PubMed ID: 12397081
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Prointerleukin-16 contains a functional CcN motif that regulates nuclear localization.
Wilson KC, Cruikshank WW, Center DM, Zhang Y
Biochemistry. 2002
PubMed ID: 12450396
Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.
Mailand N, Podtelejnikov AV, Groth A, Mann M, Bartek J, Lukas J
EMBO J. 2002
PubMed ID: 12411508
WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis.
Morisaki T, Hirota T, Iida S, Marumoto T, Hara T, Nishiyama Y, Kawasuzi M, Hiraoka T, Mimori T, Araki N, Izawa I, Inagaki M, Saya H
FEBS Lett. 2002
PubMed ID: 12372621
p34cdc2-mediated phosphorylation mobilizes microtubule-organizing centers from the apical intermediate filament scaffold in CACO-2 epithelial cells.
Figueroa Y, Wald FA, Salas PJ
J Biol Chem. 2002
PubMed ID: 12151413
Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration.
Pei JJ, Braak H, Gong CX, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF
Acta Neuropathol. 2002
PubMed ID: 12200623
Nuclear localization of CDC25B1 and serine 146 integrity are required for induction of mitosis.
Baldin V, Pelpel K, Cazales M, Cans C, Ducommun B
J Biol Chem. 2002
PubMed ID: 12107172
A novel chk1-dependent G1/M checkpoint in fission yeast.
Synnes M, Nilssen EA, Boye E, Grallert B
J Cell Sci. 2002
PubMed ID: 12186947
Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.
Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y
Mol Biol Cell. 2002
PubMed ID: 12221128
GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress.
Vairapandi M, Balliet AG, Hoffman B, Liebermann DA
J Cell Physiol. 2002
PubMed ID: 12124778
Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice.
Takemura M, Gomi H, Colucci-Guyon E, Itohara S
J Neurosci. 2002
PubMed ID: 12177195
Hepatobiliary damage and changes in hepatic gene expression caused by the antitumor drug ecteinascidin-743 (ET-743) in the female rat.
Donald S, Verschoyle RD, Edwards R, Judah DJ, Davies R, Riley J, Dinsdale D, Lopez Lazaro L, Smith AG, Gant TW, Greaves P, Gescher AJ
Cancer Res. 2002
PubMed ID: 12154027
Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope.
Castedo M, Roumier T, Blanco J, Ferri KF, Barretina J, Tintignac LA, Andreau K, Perfettini JL, Amendola A, Nardacci R, Leduc P, Ingber DE, Druillennec S, Roques B, Leibovitch SA, Vilella-Bach M, Chen J, Este JA, Modjtahedi N, Piacentini M, Kroemer G
EMBO J. 2002
PubMed ID: 12145207
Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.
Hrimech M, Yao XJ, Branton PE, Cohen EA
EMBO J. 2002
PubMed ID: 12110603
Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation.
Chang TS, Jeong W, Choi SY, Yu S, Kang SW, Rhee SG
J Biol Chem. 2002
PubMed ID: 11986303
Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA.
Liu X, Erikson RL
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12077309
Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype.
Goudreau G, Petrou P, Reneker LW, Graw J, Löster J, Gruss P
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12072567
The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype.
Okuwaki M, Tsujimoto M, Nagata K
Mol Biol Cell. 2002
PubMed ID: 12058066
Protein kinase C-beta II Is an apoptotic lamin kinase in polyomavirus-transformed, etoposide-treated pyF111 rat fibroblasts.
Chiarini A, Whitfield JF, Armato U, Dal Pra I
J Biol Chem. 2002
PubMed ID: 11901153
Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation.
Sarcevic B, Mawson A, Baker RT, Sutherland RL
EMBO J. 2002
PubMed ID: 11953320
Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE-driven transcription.
Suárez Y, Fernández C, Ledo B, Ferruelo AJ, Martín M, Vega MA, Gómez-Coronado D, Lasunción MA
Eur J Biochem. 2002
PubMed ID: 11895447
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage.
Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH, Brody LC
Nat Genet. 2002
PubMed ID: 11836499
Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function.
Fortugno P, Wall NR, Giodini A, O'Connor DS, Plescia J, Padgett KM, Tognin S, Marchisio PC, Altieri DC
J Cell Sci. 2002
PubMed ID: 11861764
Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression.
Mouland AJ, Coady M, Yao XJ, Cohen EA
Virology. 2002
PubMed ID: 11878934
RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase.
Badea T, Niculescu F, Soane L, Fosbrink M, Sorana H, Rus V, Shin ML, Rus H
J Biol Chem. 2002
PubMed ID: 11687586
Abolishment of the Tyr-15 inhibitory phosphorylation site on cdc2 reduces the radiation-induced G(2) delay, revealing a potential checkpoint in early mitosis.
Fletcher L, Cheng Y, Muschel RJ
Cancer Res. 2002
PubMed ID: 11782384
Cyclin b1 promoter activity and functional cdk1 complex formation in G1 phase of human breast cancer cells.
Barrett KL, Demiranda D, Katula KS
Cell Biol Int. 2002
PubMed ID: 11779217
Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a.
Bembenek J, Yu H
J Biol Chem. 2001
PubMed ID: 11598127
Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2).
Santaguida M, Ding Q, Bérubé G, Truscott M, Whyte P, Nepveu A
J Biol Chem. 2001
PubMed ID: 11584018
The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax.
Samuel T, Weber HO, Rauch P, Verdoodt B, Eppel JT, McShea A, Hermeking H, Funk JO
J Biol Chem. 2001
PubMed ID: 11574543
Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage.
Ando T, Kawabe T, Ohara H, Ducommun B, Itoh M, Okamoto T
J Biol Chem. 2001
PubMed ID: 11559705
Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1.
Pathan N, Aime-Sempe C, Kitada S, Basu A, Haldar S, Reed JC
Neoplasia. 2001
PubMed ID: 11774038
Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1.
Kamimoto T, Zama T, Aoki R, Muro Y, Hagiwara M
J Biol Chem. 2001
PubMed ID: 11470801
Cloning and characterization of hMAP126, a new member of mitotic spindle-associated proteins.
Chang MS, Huang CJ, Chen ML, Chen ST, Fan CC, Chu JM, Lin WC, Yang YC
Biochem Biophys Res Commun. 2001
PubMed ID: 11549262
SET-related cell division autoantigen-1 (CDA1) arrests cell growth.
Chai Z, Sarcevic B, Mawson A, Toh BH
J Biol Chem. 2001
PubMed ID: 11395479
Large-scale identification of mammalian proteins localized to nuclear sub-compartments.
Sutherland HG, Mumford GK, Newton K, Ford LV, Farrall R, Dellaire G, Cáceres JF, Bickmore WA
Hum Mol Genet. 2001
PubMed ID: 11555636
HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.
Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y
Virology. 2001
PubMed ID: 11531413
FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis.
Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11504921
Phosphorylation of MAP4 affects microtubule properties and cell cycle progression.
Chang W, Gruber D, Chari S, Kitazawa H, Hamazumi Y, Hisanaga S, Bulinski JC
J Cell Sci. 2001
PubMed ID: 11683421
Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B.
Catania MG, Mischel PS, Vinters HV
J Neuropathol Exp Neurol. 2001
PubMed ID: 11444800
Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.
Tokuyama Y, Horn HF, Kawamura K, Tarapore P, Fukasawa K
J Biol Chem. 2001
PubMed ID: 11278991
Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase.
Sahlgren CM, Mikhailov A, Hellman J, Chou YH, Lendahl U, Goldman RD, Eriksson JE
J Biol Chem. 2001
PubMed ID: 11278541
Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34(cdc2).
Ababneh M, Götz C, Montenarh M
Biochem Biophys Res Commun. 2001
PubMed ID: 11327730
Patched1 interacts with cyclin B1 to regulate cell cycle progression.
Barnes EA, Kong M, Ollendorff V, Donoghue DJ
EMBO J. 2001
PubMed ID: 11331587
Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.
Geley S, Kramer E, Gieffers C, Gannon J, Peters JM, Hunt T
J Cell Biol. 2001
PubMed ID: 11285280
Two immunologically distinct human DNA polymerase alpha-primase subpopulations are involved in cellular DNA replication.
Dehde S, Rohaly G, Schub O, Nasheuer HP, Bohn W, Chemnitz J, Deppert W, Dornreiter I
Mol Cell Biol. 2001
PubMed ID: 11259605
Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2.
Floyd SR, Porro EB, Slepnev VI, Ochoa GC, Tsai LH, De Camilli P
J Biol Chem. 2001
PubMed ID: 11113134
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Nerve growth factor signaling, neuroprotection, and neural repair.
Sofroniew MV, Howe CL, Mobley WC
Annu Rev Neurosci. 2001
PubMed ID: 11520933
Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1.
Pathan N, Aime-Sempe C, Kitada S, Haldar S, Reed JC
Neoplasia. 2001
PubMed ID: 11326318
Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha.
Freire J, Covelo G, Sarandeses C, Díaz-Jullien C, Freire M
Biochem Cell Biol. 2001
PubMed ID: 11310559
Differences in phosphorylation of human and chicken stathmin by MAP kinase.
Antonsson B, Kassel DB, Ruchti E, Grenningloh G
J Cell Biochem. 2001
PubMed ID: 11135364
Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.
Garrett S, Barton WA, Knights R, Jin P, Morgan DO, Fisher RP
Mol Cell Biol. 2001
PubMed ID: 11113184
Identification of a functional domain in a GADD45-mediated G2/M checkpoint.
Yang Q, Manicone A, Coursen JD, Linke SP, Nagashima M, Forgues M, Wang XW
J Biol Chem. 2000
PubMed ID: 10973963
Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin.
O'Connor DS, Grossman D, Plescia J, Li F, Zhang H, Villa A, Tognin S, Marchisio PC, Altieri DC
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11069302
The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion.
Mayor T, Stierhof YD, Tanaka K, Fry AM, Nigg EA
J Cell Biol. 2000
PubMed ID: 11076968
Requirement of Cyclin/Cdk2 and protein phosphatase 1 activity for chromatin assembly factor 1-dependent chromatin assembly during DNA synthesis.
Keller C, Krude T
J Biol Chem. 2000
PubMed ID: 10938080
DNA cloning using in vitro site-specific recombination.
Hartley JL, Temple GF, Brasch MA
Genome Res. 2000
PubMed ID: 11076863
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
An essential phosphorylation-site domain of human cdc25C interacts with both 14-3-3 and cyclins.
Morris MC, Heitz A, Mery J, Heitz F, Divita G
J Biol Chem. 2000
PubMed ID: 10864927
On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells.
Arooz T, Yam CH, Siu WY, Lau A, Li KK, Poon RY
Biochemistry. 2000
PubMed ID: 10924145
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.
Hrimech M, Yao XJ, Branton PE, Cohen EA
EMBO J. 2000
PubMed ID: 10921877
Target gene specificity of E2F and pocket protein family members in living cells.
Wells J, Boyd KE, Fry CJ, Bartley SM, Farnham PJ
Mol Cell Biol. 2000
PubMed ID: 10913163
Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression.
Laronga C, Yang HY, Neal C, Lee MH
J Biol Chem. 2000
PubMed ID: 10767298
The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.
Luciani MG, Hutchins JR, Zheleva D, Hupp TR
J Mol Biol. 2000
PubMed ID: 10884347
Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint.
Elder RT, Yu M, Chen M, Edelson S, Zhao Y
Virus Res. 2000
PubMed ID: 10958988
Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation.
Kariya K, Koyama S, Nakashima S, Oshiro T, Morinaka K, Kikuchi A
J Biol Chem. 2000
PubMed ID: 10764745
The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression.
Jin S, Antinore MJ, Lung FD, Dong X, Zhao H, Fan F, Colchagie AB, Blanck P, Roller PP, Fornace AJ, Zhan Q
J Biol Chem. 2000
PubMed ID: 10747892
p53 regulation of G(2) checkpoint is retinoblastoma protein dependent.
Flatt PM, Tang LJ, Scatena CD, Szak ST, Pietenpol JA
Mol Cell Biol. 2000
PubMed ID: 10825186
Mitotic regulation of the APC activator proteins CDC20 and CDH1.
Kramer ER, Scheuringer N, Podtelejnikov AV, Mann M, Peters JM
Mol Biol Cell. 2000
PubMed ID: 10793135
The mitotic phosphorylation cycle of the cis-Golgi matrix protein GM130.
Lowe M, Gonatas NK, Warren G
J Cell Biol. 2000
PubMed ID: 10769027
Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression.
Takahashi Y, Rayman JB, Dynlacht BD
Genes Dev. 2000
PubMed ID: 10766737
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
Reuther GW, Der CJ
Curr Opin Cell Biol. 2000
PubMed ID: 10712923
Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction.
Kong M, Barnes EA, Ollendorff V, Donoghue DJ
EMBO J. 2000
PubMed ID: 10716937
Architecture of high mobility group protein I-C.DNA complex and its perturbation upon phosphorylation by Cdc2 kinase.
Schwanbeck R, Manfioletti G, Wiśniewski JR
J Biol Chem. 2000
PubMed ID: 10636877
Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product.
Ramos-Morales F, Domínguez A, Romero F, Luna R, Multon MC, Pintor-Toro JA, Tortolero M
Oncogene. 2000
PubMed ID: 10656688
Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases.
Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T
Oncogene. 1999
PubMed ID: 10602502
Cdc2 and Cdk2 kinase activated by transforming growth factor-beta1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells.
Choi KS, Eom YW, Kang Y, Ha MJ, Rhee H, Yoon JW, Kim SJ
J Biol Chem. 1999
PubMed ID: 10542199
Mechanisms of G2 arrest in response to overexpression of p53.
Taylor WR, DePrimo SE, Agarwal A, Agarwal ML, Schönthal AH, Katula KS, Stark GR
Mol Biol Cell. 1999
PubMed ID: 10564259
The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase.
Ball HJ, Melnick A, Shaknovich R, Kohanski RA, Licht JD
Nucleic Acids Res. 1999
PubMed ID: 10497277
Biochemical characterization of pKi67 with the identification of a mitotic-specific form associated with hyperphosphorylation and altered DNA binding.
MacCallum DE, Hall PA
Exp Cell Res. 1999
PubMed ID: 10502411
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.
Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B
Nature. 1999
PubMed ID: 10524633
The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression.
Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T
J Cell Sci. 1999
PubMed ID: 10504341
A new mouse insertional mutation that causes sensorineural deafness and vestibular defects.
Alagramam KN, Kwon HY, Cacheiro NL, Stubbs L, Wright CG, Erway LC, Woychik RP
Genetics. 1999
PubMed ID: 10430593
Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal.
Hagting A, Jackman M, Simpson K, Pines J
Curr Biol. 1999
PubMed ID: 10395539
Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes.
Liu F, Rothblum-Oviatt C, Ryan CE, Piwnica-Worms H
Mol Cell Biol. 1999
PubMed ID: 10373560
The small GTPases Rab5a, Rab5b and Rab5c are differentially phosphorylated in vitro.
Chiariello M, Bruni CB, Bucci C
FEBS Lett. 1999
PubMed ID: 10403367
Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45.
Zhan Q, Antinore MJ, Wang XW, Carrier F, Smith ML, Harris CC, Fornace AJ
Oncogene. 1999
PubMed ID: 10362260
A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division.
Cai SY, Babbitt RW, Marchesi VT
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10077596
Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity.
Tao W, Zhang S, Turenchalk GS, Stewart RA, St John MA, Chen W, Xu T
Nat Genet. 1999
PubMed ID: 9988268
Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest.
Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E
Mol Cell Biol. 1999
PubMed ID: 9891079
Ribonucleotide reductase R2 protein is phosphorylated at serine-20 by P34cdc2 kinase.
Chan AK, Persad S, Litchfield DW, Wright JA
Biochim Biophys Acta. 1999
PubMed ID: 9990288
Functional association of TGF-beta receptor II with cyclin B.
Liu JH, Wei S, Burnette PK, Gamero AM, Hutton M, Djeu JY
Oncogene. 1999
PubMed ID: 9926943
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Characterization of the murine cdc2 gene.
Jun D, Park HK, Nordin AA, Nagel JE, Kim YH
Mol Cells. 1998
PubMed ID: 9895127
Cyclin A1 is required for meiosis in the male mouse.
Liu D, Matzuk MM, Sung WK, Guo Q, Wang P, Wolgemuth DJ
Nat Genet. 1998
PubMed ID: 9843212
Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis.
Lowe M, Rabouille C, Nakamura N, Watson R, Jackman M, Jämsä E, Rahman D, Pappin DJ, Warren G
Cell. 1998
PubMed ID: 9753325
A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain.
Hofmann K, Bucher P, Kajava AV
J Mol Biol. 1998
PubMed ID: 9733650
Activation of androgen receptor function by a novel nuclear protein kinase.
Moilanen AM, Karvonen U, Poukka H, Jänne OA, Palvimo JJ
Mol Biol Cell. 1998
PubMed ID: 9725910
The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease.
Illenberger S, Zheng-Fischhöfer Q, Preuss U, Stamer K, Baumann K, Trinczek B, Biernat J, Godemann R, Mandelkow EM, Mandelkow E
Mol Biol Cell. 1998
PubMed ID: 9614189
Nuclear localization of cyclin B1 controls mitotic entry after DNA damage.
Jin P, Hardy S, Morgan DO
J Cell Biol. 1998
PubMed ID: 9585407
Serine 13 is the site of mitotic phosphorylation of human thymidine kinase.
Chang ZF, Huang DY, Chi LM
J Biol Chem. 1998
PubMed ID: 9575153
Multiple phosphorylation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B by casein kinase II and p60c-src in vitro.
Jung EJ, Kang YS, Kim CW
Biochem Biophys Res Commun. 1998
PubMed ID: 9600099
The identification and characterization of expression of Pftaire-1, a novel Cdk family member, suggest its function in the mouse testis and nervous system.
Besset V, Rhee K, Wolgemuth DJ
Mol Reprod Dev. 1998
PubMed ID: 9547506
HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator.
Felzien LK, Woffendin C, Hottiger MO, Subbramanian RA, Cohen EA, Nabel GJ
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9560267
Identification of in vitro phosphorylation sites in the growth cone protein SCG10. Effect Of phosphorylation site mutants on microtubule-destabilizing activity.
Antonsson B, Kassel DB, Di Paolo G, Lutjens R, Riederer BM, Grenningloh G
J Biol Chem. 1998
PubMed ID: 9525956
Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins.
Ku NO, Liao J, Omary MB
EMBO J. 1998
PubMed ID: 9524113
HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle.
Mahalingam S, Ayyavoo V, Patel M, Kieber-Emmons T, Kao GD, Muschel RJ, Weiner DB
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9520381
T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21.
Ohta T, Okamoto K, Isohashi F, Shibata K, Fukuda M, Yamaguchi S, Xiong Y
Cancer Res. 1998
PubMed ID: 9515786
Induction of growth arrest and cell death by overexpression of the cyclin-Cdk inhibitor p21 in hamster BHK21 cells.
Sekiguchi T, Hunter T
Oncogene. 1998
PubMed ID: 9467962
Cdc2-mediated phosphorylation of the gap junction protein, connexin43, during mitosis.
Kanemitsu MY, Jiang W, Eckhart W
Cell Growth Differ. 1998
PubMed ID: 9438384
MAP4 is the in vivo substrate for CDC2 kinase in HeLa cells: identification of an M-phase specific and a cell cycle-independent phosphorylation site in MAP4.
Ookata K, Hisanaga S, Sugita M, Okuyama A, Murofushi H, Kitazawa H, Chari S, Bulinski JC, Kishimoto T
Biochemistry. 1997
PubMed ID: 9398320
Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2.
Hogg A, Schirm S, Nakagoshi H, Bartley P, Ishii S, Bishop JM, Gonda TJ
Oncogene. 1997
PubMed ID: 9416832
The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells.
Poon RY, Chau MS, Yamashita K, Hunter T
Cancer Res. 1997
PubMed ID: 9371520
Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells.
Zernik-Kobak M, Vasunia K, Connelly M, Anderson CW, Dixon K
J Biol Chem. 1997
PubMed ID: 9295339
Phosphorylation of the Src substrate Sam68 by Cdc2 during mitosis.
Resnick RJ, Taylor SJ, Lin Q, Shalloway D
Oncogene. 1997
PubMed ID: 9315091
Dual requirement for a newly identified phosphorylation site in p70s6k.
Moser BA, Dennis PB, Pullen N, Pearson RB, Williamson NA, Wettenhall RE, Kozma SC, Thomas G
Mol Cell Biol. 1997
PubMed ID: 9271440
Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity.
Booher RN, Holman PS, Fattaey A
J Biol Chem. 1997
PubMed ID: 9268380
HSP70-2 is required for CDC2 kinase activity in meiosis I of mouse spermatocytes.
Zhu D, Dix DJ, Eddy EM
Development. 1997
PubMed ID: 9247342
The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2.
Kupfer GM, Yamashita T, Naf D, Suliman A, Asano S, D'Andrea AD
Blood. 1997
PubMed ID: 9242535
Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150.
Blangy A, Arnaud L, Nigg EA
J Biol Chem. 1997
PubMed ID: 9235942
BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases.
Wang H, Shao N, Ding QM, Cui J, Reddy ES, Rao VN
Oncogene. 1997
PubMed ID: 9244350
A novel cdc2-related protein kinase expressed in the nervous system.
Lazzaro MA, Albert PR, Julien JP
J Neurochem. 1997
PubMed ID: 9202329
Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest.
Stewart SA, Poon B, Jowett JB, Chen IS
J Virol. 1997
PubMed ID: 9188632
The NIMA-related kinase 2, Nek2, is expressed in specific stages of the meiotic cell cycle and associates with meiotic chromosomes.
Rhee K, Wolgemuth DJ
Development. 1997
PubMed ID: 9187143
Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard.
Poon B, Jowett JB, Stewart SA, Armstrong RW, Rishton GM, Chen IS
J Virol. 1997
PubMed ID: 9094673
Cdc25 protein phosphatases in cell proliferation.
Draetta G, Eckstein J
Biochim Biophys Acta. 1997
PubMed ID: 9141461
Phosphorylation of Alzheimer beta-amyloid precursor-like proteins.
Suzuki T, Ando K, Isohara T, Oishi M, Lim GS, Satoh Y, Wasco W, Tanzi RE, Nairn AC, Greengard P, Gandy SE, Kirino Y
Biochemistry. 1997
PubMed ID: 9109675
Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH.
Rossignol M, Kolb-Cheynel I, Egly JM
EMBO J. 1997
PubMed ID: 9130708
Purification, characterization, and in vitro phosphorylation of the neuron-specific membrane-associated protein SCG10.
Antonsson B, Lütjens R, Di Paolo G, Kassel D, Allet B, Bernard A, Catsicas S, Grenningloh G
Protein Expr Purif. 1997
PubMed ID: 9126608
Signal transduction by the neurotrophin receptors.
Kaplan DR, Miller FD
Curr Opin Cell Biol. 1997
PubMed ID: 9069267
The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex.
Liu F, Stanton JJ, Wu Z, Piwnica-Worms H
Mol Cell Biol. 1997
PubMed ID: 9001210
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
Meijer L, Borgne A, Mulner O, Chong JP, Blow JJ, Inagaki N, Inagaki M, Delcros JG, Moulinoux JP
Eur J Biochem. 1997
PubMed ID: 9030781
Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death.
Ahuja HS, Zhu Y, Zakeri Z
Dev Genet. 1997
PubMed ID: 9438340
The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2.
Pathan NI, Geahlen RL, Harrison ML
J Biol Chem. 1996
PubMed ID: 8910336
Phosphorylation of HIV-1 Rev protein: implication of protein kinase CK2 and pro-directed kinases.
Meggio F, D'Agostino DM, Ciminale V, Chieco-Bianchi L, Pinna LA
Biochem Biophys Res Commun. 1996
PubMed ID: 8806671
Fine genetic map of mouse chromosome 10 around the polycystic kidney disease gene, jcpk, and ankyrin 3.
Bryda EC, Ling H, Rathbun DE, Burmeister M, Flaherty L
Genomics. 1996
PubMed ID: 8812475
Cell cycle-dependent phosphorylation of nucleoporins and nuclear pore membrane protein Gp210.
Favreau C, Worman HJ, Wozniak RW, Frappier T, Courvalin JC
Biochemistry. 1996
PubMed ID: 8672508
Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage.
Poon RY, Jiang W, Toyoshima H, Hunter T
J Biol Chem. 1996
PubMed ID: 8662825
Identification of plectin as a substrate of p34cdc2 kinase and mapping of a single phosphorylation site.
Malecz N, Foisner R, Stadler C, Wiche G
J Biol Chem. 1996
PubMed ID: 8626512
Identification of a consensus cyclin-dependent kinase phosphorylation site unique to the nuclear form of human deoxyuridine triphosphate nucleotidohydrolase.
Ladner RD, Carr SA, Huddleston MJ, McNulty DE, Caradonna SJ
J Biol Chem. 1996
PubMed ID: 8631817
An accumulation of p34cdc2 at the end of mouse oocyte growth correlates with the acquisition of meiotic competence.
de Vant'ery C, Gavin AC, Vassalli JD, Schorderet-Slatkine S
Dev Biol. 1996
PubMed ID: 8631505
Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein.
Iyer N, Reagan MS, Wu KJ, Canagarajah B, Friedberg EC
Biochemistry. 1996
PubMed ID: 8652557
Regulation of cyclin and cyclin-dependent kinase gene expression during lens differentiation requires the retinoblastoma protein.
Fromm L, Overbeek PA
Oncogene. 1996
PubMed ID: 8552401
A distinct cyclin A is expressed in germ cells in the mouse.
Sweeney C, Murphy M, Kubelka M, Ravnik SE, Hawkins CF, Wolgemuth DJ, Carrington M
Development. 1996
PubMed ID: 8565853
Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo.
Blangy A, Lane HA, d'Hérin P, Harper M, Kress M, Nigg EA
Cell. 1995
PubMed ID: 8548803
Human immunodeficiency virus 1 envelope-initiated G2-phase programmed cell death.
Kolesnitchenko V, Wahl LM, Tian H, Sunila I, Tani Y, Hartmann DP, Cossman J, Raffeld M, Orenstein J, Samelson LE, Cohen DI
Proc Natl Acad Sci U S A. 1995
PubMed ID: 8524869
Cdk family genes are expressed not only in dividing but also in terminally differentiated mouse germ cells, suggesting their possible function during both cell division and differentiation.
Rhee K, Wolgemuth DJ
Dev Dyn. 1995
PubMed ID: 8601034
Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr.
Di Marzio P, Choe S, Ebright M, Knoblauch R, Landau NR
J Virol. 1995
PubMed ID: 7494303
Characterization of the mitotic specific phosphorylation site of histone H1. Absence of a consensus sequence for the p34cdc2/cyclin B kinase.
Gurley LR, Valdez JG, Buchanan JS
J Biol Chem. 1995
PubMed ID: 7499230
Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B.
Re F, Braaten D, Franke EK, Luban J
J Virol. 1995
PubMed ID: 7474100
Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity.
He J, Choe S, Walker R, Di Marzio P, Morgan DO, Landau NR
J Virol. 1995
PubMed ID: 7474080
Phosphorylation of casein kinase II by p34cdc2. Identification of phosphorylation sites using phosphorylation site mutants in vitro.
Bosc DG, Slominski E, Sichler C, Litchfield DW
J Biol Chem. 1995
PubMed ID: 7592773
The protein kinase from mitotic human cells that phosphorylates Ser-209 on the casein kinase II beta-subunit is p34cdc2.
Litchfield DW, Bosc DG, Slominski E
Biochim Biophys Acta. 1995
PubMed ID: 7578274
Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.
Mueller PR, Coleman TR, Kumagai A, Dunphy WG
Science. 1995
PubMed ID: 7569953
Isolation of an ubiquitously expressed cDNA encoding human dynamin II, a member of the large GTP-binding protein family.
Diatloff-Zito C, Gordon AJ, Duchaud E, Merlin G
Gene. 1995
PubMed ID: 7590285
The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle.
Jowett JB, Planelles V, Poon B, Shah NP, Chen ML, Chen IS
J Virol. 1995
PubMed ID: 7666531
Human topoisomerase II alpha is phosphorylated in a cell-cycle phase-dependent manner by a proline-directed kinase.
Wells NJ, Hickson ID
Eur J Biochem. 1995
PubMed ID: 7635160
Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.
Golsteyn RM, Mundt KE, Fry AM, Nigg EA
J Cell Biol. 1995
PubMed ID: 7790358
Ubiquitin-activating enzyme, E1, is phosphorylated in mammalian cells by the protein kinase Cdc2.
Nagai Y, Kaneda S, Nomura K, Yasuda H, Seno T, Yamao F
J Cell Sci. 1995
PubMed ID: 7673335
The G1/S boundary-specific enhancer of the rat cdc2 promoter.
Shimizu M, Ichikawa E, Inoue U, Nakamura T, Nakajima T, Nojima H, Okayama H, Oda K
Mol Cell Biol. 1995
PubMed ID: 7739568
Expression of Rb, E2F1, cdc2, and D, and B cyclins in developing spinal cord.
Zhao J, Nornes HO, Neuman T
Neurosci Lett. 1995
PubMed ID: 7624053
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein.
Li CJ, Friedman DJ, Wang C, Metelev V, Pardee AB
Science. 1995
PubMed ID: 7716549
Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus.
Jackman M, Firth M, Pines J
EMBO J. 1995
PubMed ID: 7737117
Phosphorylation of ubiquitin-activating enzyme in cultured cells.
Cook JC, Chock PB
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7724583
Granzymes: exogenous proteinases that induce target cell apoptosis.
Smyth MJ, Trapani JA
Immunol Today. 1995
PubMed ID: 7734049
Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics.
Ookata K, Hisanaga S, Bulinski JC, Murofushi H, Aizawa H, Itoh TJ, Hotani H, Okumura E, Tachibana K, Kishimoto T
J Cell Biol. 1995
PubMed ID: 7876309
Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis.
Compton DA, Luo C
J Cell Sci. 1995
PubMed ID: 7769006
Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2.
Desai D, Wessling HC, Fisher RP, Morgan DO
Mol Cell Biol. 1995
PubMed ID: 7799941
Visualization and function of vimentin phosphorylation by cdc2 kinase during mitosis.
Tsujimura K, Ogawara M, Takeuchi Y, Imajoh-Ohmi S, Ha MH, Inagaki M
J Biol Chem. 1994
PubMed ID: 7983050
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.
Xu M, Sheppard KA, Peng CY, Yee AS, Piwnica-Worms H
Mol Cell Biol. 1994
PubMed ID: 7969176
Association of proliferating cell nuclear antigen with cyclin-dependent kinases and cyclins in normal and transformed human T lymphocytes.
Szepesi A, Gelfand EW, Lucas JJ
Blood. 1994
PubMed ID: 7949095
Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems.
Ino H, Ishizuka T, Chiba T, Tatibana M
Brain Res. 1994
PubMed ID: 7834371
p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C.
Kharbanda S, Yuan ZM, Taneja N, Weichselbaum R, Kufe D
Oncogene. 1994
PubMed ID: 8084605
Identification, assay, and purification of a Cdc2-activating threonine-161 protein kinase from human cells.
Williams RT, Wu L, Carbonaro-Hall DA, Hall FL
Arch Biochem Biophys. 1994
PubMed ID: 7944411
Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein.
Fagan R, Flint KJ, Jones N
Cell. 1994
PubMed ID: 8087847
The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B.
Pines J, Hunter T
EMBO J. 1994
PubMed ID: 8070405
Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation.
Kharbanda S, Yuan ZM, Rubin E, Weichselbaum R, Kufe D
J Biol Chem. 1994
PubMed ID: 8051175
Elongation factor EF-1 delta, a new target for maturation-promoting factor in Xenopus oocytes.
Mulner-Lorillon O, Minella O, Cormier P, Capony JP, Cavadore JC, Morales J, Poulhe R, Bellé R
J Biol Chem. 1994
PubMed ID: 8051108
Identification of phosphorylation sites on glial fibrillary acidic protein for cdc2 kinase and Ca(2+)-calmodulin-dependent protein kinase II.
Tsujimura K, Tanaka J, Ando S, Matsuoka Y, Kusubata M, Sugiura H, Yamauchi T, Inagaki M
J Biochem. 1994
PubMed ID: 7822264
Identification of nuclear beta II protein kinase C as a mitotic lamin kinase.
Goss VL, Hocevar BA, Thompson LJ, Stratton CA, Burns DJ, Fields AP
J Biol Chem. 1994
PubMed ID: 8034666
Changes in cell cycle-associated gene expression in a model of impaired liver regeneration.
Albrecht JH, Hoffman JS, Kren BT, Steer CJ
FEBS Lett. 1994
PubMed ID: 8033995
KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases.
Hannon GJ, Casso D, Beach D
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8127873
Cell-cycle-regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38.
Brattsand G, Marklund U, Nylander K, Roos G, Gullberg M
Eur J Biochem. 1994
PubMed ID: 8125092
Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis.
Strausfeld U, Fernandez A, Capony JP, Girard F, Lautredou N, Derancourt J, Labbe JC, Lamb NJ
J Biol Chem. 1994
PubMed ID: 8119945
Functional analysis of phosphorylation sites in human lamin A controlling lamin disassembly, nuclear transport and assembly.
Haas M, Jost E
Eur J Cell Biol. 1993
PubMed ID: 7925482
Regulation of proliferation-specific and differentiation-specific genes during senescence of human epidermal keratinocyte and mammary epithelial cells.
Saunders NA, Smith RJ, Jetten AM
Biochem Biophys Res Commun. 1993
PubMed ID: 7902715
Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2.
Gyuris J, Golemis E, Chertkov H, Brent R
Cell. 1993
PubMed ID: 8242750
Multiple and cooperative phosphorylation events regulate the CREM activator function.
de Groot RP, den Hertog J, Vandenheede JR, Goris J, Sassone-Corsi P
EMBO J. 1993
PubMed ID: 8404858
Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2.
Beretta L, Dobránsky T, Sobel A
J Biol Chem. 1993
PubMed ID: 8376365
Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase.
Marklund U, Brattsand G, Shingler V, Gullberg M
J Biol Chem. 1993
PubMed ID: 8325880
Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation.
Flint AJ, Gebbink MF, Franza BR, Hill DE, Tonks NK
EMBO J. 1993
PubMed ID: 8491187
Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15.
Sebastian B, Kakizuka A, Hunter T
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8475101
G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.
O'Connor PM, Ferris DK, Pagano M, Draetta G, Pines J, Hunter T, Longo DL, Kohn KW
J Biol Chem. 1993
PubMed ID: 8463339
Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase.
Honda R, Ohba Y, Nagata A, Okayama H, Yasuda H
FEBS Lett. 1993
PubMed ID: 8440392
Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase.
Lees EM, Harlow E
Mol Cell Biol. 1993
PubMed ID: 8423786
Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.
McGowan CH, Russell P
EMBO J. 1993
PubMed ID: 8428596
Reversible phosphorylation--dephosphorylation determines the localization of rab4 during the cell cycle.
van der Sluijs P, Hull M, Huber LA, Mâle P, Goud B, Mellman I
EMBO J. 1992
PubMed ID: 1425574
A deficiency in the mechanism for p34cdc2 protein kinase activation in mouse embryos arrested at 2-cell stage.
Aoki F, Choi T, Mori M, Yamashita M, Nagahama Y, Kohmoto K
Dev Biol. 1992
PubMed ID: 1426634
Casein kinase II phosphorylates p34cdc2 kinase in G1 phase of the HeLa cell division cycle.
Russo GL, Vandenberg MT, Yu IJ, Bae YS, Franza BR, Marshak DR
J Biol Chem. 1992
PubMed ID: 1400350
Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis.
Rubinfeld B, Crosier WJ, Albert I, Conroy L, Clark R, McCormick F, Polakis P
Mol Cell Biol. 1992
PubMed ID: 1406653
Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase.
Parker LL, Piwnica-Worms H
Science. 1992
PubMed ID: 1384126
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.
Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM
Science. 1992
PubMed ID: 1388288
Distinct forms of human CDC2 identified by novel monoclonal antibodies.
Lukás J, Draetta G, Bartek J
Eur J Biochem. 1992
PubMed ID: 1628647
cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication.
Dutta A, Stillman B
EMBO J. 1992
PubMed ID: 1318195
Evolution of the mammalian G protein alpha subunit multigene family.
Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI
Nat Genet. 1992
PubMed ID: 1302014
The role of the IGF1 receptor in the regulation of cdc2 mRNA levels in fibroblasts.
Surmacz E, Nugent P, Pietrzkowski Z, Baserga R
Exp Cell Res. 1992
PubMed ID: 1371961
Interaction between the cell-cycle-control proteins p34cdc2 and p9CKShs2. Evidence for two cooperative binding domains in p9CKShs2.
Azzi L, Meijer L, Reed SI, Pidikiti R, Tung HY
Eur J Biochem. 1992
PubMed ID: 1310466
A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression.
Seth A, Alvarez E, Gupta S, Davis RJ
J Biol Chem. 1991
PubMed ID: 1748630
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.
Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E
EMBO J. 1991
PubMed ID: 1756735
Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein.
Nissen MS, Langan TA, Reeves R
J Biol Chem. 1991
PubMed ID: 1939057
Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.
Pines J, Hunter T
J Cell Biol. 1991
PubMed ID: 1717476
Regional assignment of the human cell cycle control gene CDC2 to chromosome 10q21 by in situ hybridization.
Nazarenko SA, Ostroverhova NV, Spurr NK
Hum Genet. 1991
PubMed ID: 1916766
Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein.
Strausfeld U, Labbé JC, Fesquet D, Cavadore JC, Picard A, Sadhu K, Russell P, Dorée M
Nature. 1991
PubMed ID: 1828290
High-mobility-group proteins P1, I and Y as substrates of the M-phase-specific p34cdc2/cyclincdc13 kinase.
Meijer L, Ostvold AC, Walass SI, Lund T, Laland SG
Eur J Biochem. 1991
PubMed ID: 2013279
The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product.
Th'ng JP, Wright PS, Hamaguchi J, Lee MG, Norbury CJ, Nurse P, Bradbury EM
Cell. 1990
PubMed ID: 2208288
Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe.
Richardson HE, Stueland CS, Thomas J, Russell P, Reed SI
Genes Dev. 1990
PubMed ID: 2227411
A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross.
Justice MJ, Siracusa LD, Gilbert DJ, Heisterkamp N, Groffen J, Chada K, Silan CM, Copeland NG, Jenkins NA
Genetics. 1990
PubMed ID: 1975791
Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis.
Heald R, McKeon F
Cell. 1990
PubMed ID: 2344612
Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity.
Kipreos ET, Wang JY
Science. 1990
PubMed ID: 2183353
Cloning of the mouse homologue of the yeast cell cycle control gene cdc2.
Spurr NK, Gough AC, Lee MG
DNA Seq. 1990
PubMed ID: 2132958
p34cdc2 is located in both nucleus and cytoplasm; part is centrosomally associated at G2/M and enters vesicles at anaphase.
Bailly E, Dorée M, Nurse P, Bornens M
EMBO J. 1989
PubMed ID: 2686978
Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2.
Pines J, Hunter T
Cell. 1989
PubMed ID: 2570636
Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis.
Morla AO, Draetta G, Beach D, Wang JY
Cell. 1989
PubMed ID: 2473839
Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2.
Cisek LJ, Corden JL
Nature. 1989
PubMed ID: 2662013
The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells.
Riabowol K, Draetta G, Brizuela L, Vandre D, Beach D
Cell. 1989
PubMed ID: 2541912
Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF.
Draetta G, Luca F, Westendorf J, Brizuela L, Ruderman J, Beach D
Cell. 1989
PubMed ID: 2538242
cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF.
Arion D, Meijer L, Brizuela L, Beach D
Cell. 1988
PubMed ID: 2844417
Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement.
Draetta G, Beach D
Cell. 1988
PubMed ID: 3289755
Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2.
Lee MG, Nurse P
Nature. 1987
PubMed ID: 3553962
[Biologic availability and "1st pass" effect of drugs]
Rietbrock N, Keller F
Fortschr Med. 1977
PubMed ID: 914146

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	983	12534	54237
EnsEMBL Gene(s)	ENSG00000170312	ENSMUSG00000019942	ENSRNOG00000000632
Unigene	Hs.732435	Mm.281367	Rn.6934
Homologene	CDK1	Cdk1	Cdk1
OMIM	116940	N/A	N/A
GeneCards	CDK1	N/A	N/A
Beta Cell Genomics	DT.100019020 DT.455976 DT.87046806 DT.99984670	DT.536135	N/A
Reactome	P06493	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	983	12534	54237

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
CDK1	HDAC5	BioGRID	empirical	21081666
CDK1	ACTR3	IntAct, BioGRID	empirical	20360068
CDK1	ACTR1A	Reactome	predicted	12852856
CDK1	AKAP9	Reactome	predicted	12852856
CDK1	CDK5	IntAct, BioGRID	empirical	20360068
CDK1	CDK7	HPRD	empirical	7944411 11113184
CDK1	CDKN1A	HPRD, BioGRID	empirical	9467962 17679094 14749395 11559705
CDK1	CDKN1B	IntAct, BioGRID	empirical	20360068
CDK1	CDKN1C	IntAct, BioGRID	empirical	20360068
CDK1	CCNO	IntAct, BioGRID	empirical	20360068
CDK1	CDKN3	HPRD, MINT, BioGRID	empirical	8127873 8242750
CDK1	TUBB4A	Reactome	predicted	12852856
CDK1	TUBB4B	Reactome	predicted	12852856
CDK1	KAT5	HPRD, BioGRID	empirical	12468530
CDK1	DCTN2	Reactome	predicted	12852856
CDK1	PRPF8	IntAct, BioGRID	empirical	20360068
CDK1	USP16	HPRD	empirical	10077596
CDK1	SPAG5	HPRD, BioGRID	empirical	11549262
CDK1	KHDRBS1	HPRD	empirical	9315091
CDK1	CETN2	Reactome	predicted	12852856
CDK1	PLK4	Reactome	predicted	12852856
CDK1	NES	HPRD	empirical	12832492 11278541
CDK1	SDCCAG8	Reactome	predicted	12852856
CDK1	USP19	IntAct, BioGRID	empirical	19615732
CDK1	GADD45G	HPRD, BioGRID	empirical	10973963 12124778
CDK1	RCC1	HPRD	empirical	15014043
CDK1	CNTRL	Reactome	predicted	12852856
CDK1	STMN2	HPRD	empirical	9525956 9126608
CDK1	FGFR1OP	Reactome	predicted	12852856
CDK1	LZTS1	HPRD	empirical	11504921
CDK1	CEP250	Reactome	predicted	12852856
CDK1	AKAP2	IntAct	empirical	20360068
CDK1	DCTN3	Reactome	predicted	12852856
CDK1	UHRF2	BioGRID	empirical	21952639
CDK1	CKS1B	IntAct, BioGRID	empirical	20360068
CDK1	CKS2	HPRD, IntAct, BioGRID	empirical	2227411 20360068
CDK1	NEDD1	Reactome	predicted	12852856
CDK1	C19orf21	IntAct, BioGRID	empirical	20360068
CDK1	CPS1	IntAct, BioGRID	empirical	20360068
CDK1	CREM	HPRD	empirical	8404858
CDK1	HNRNPA1L2	IntAct, BioGRID	empirical	20360068
CDK1	CSNK1D	Reactome	predicted	12852856
CDK1	CSNK1E	Reactome	predicted	12852856
CDK1	CSNK2A1	HPRD, BioGRID	empirical	7592773 1400350
CDK1	CSNK2B	HPRD	empirical	7578274
CDK1	CUX1	HPRD, BioGRID	empirical	11584018
CDK1	CDCA2	BioGRID	empirical	16998479
CDK1	DAB2	HPRD, BioGRID	empirical	12881709
CDK1	DCTN1	IntAct, BioGRID, Reactome	empirical	20360068 12852856
CDK1	GADD45A	HPRD, BioGRID	empirical	10973963 10362260 10747892 12124778
CDK1	DDX5	IntAct, BioGRID	empirical	20360068
CDK1	DYNC1H1	IntAct, BioGRID, Reactome	empirical	20360068 12852856
CDK1	DYNC1I2	Reactome	predicted	12852856
CDK1	DNM2	HPRD	empirical	7590285
CDK1	DUT	HPRD	empirical	8631817
CDK1	E2F1	HPRD	empirical	8087847
CDK1	E2F4	IntAct	empirical	20946988
CDK1	TYMP	IntAct, BioGRID	empirical	20360068
CDK1	ECT2	HPRD	empirical	16247472
CDK1	EEF1D	HPRD	empirical	8051108 12551973
CDK1	EGFR	IntAct	empirical	15657067
CDK1	MLKL	IntAct	empirical	21988832
CDK1	EIF4A1	IntAct, BioGRID	empirical	20360068
CDK1	ERCC2	HPRD	empirical	8652557
CDK1	ESRRB	BioGRID	empirical	20362541
CDK1	FANCA	HPRD	empirical	15367677
CDK1	FANCC	HPRD, MINT, BioGRID	empirical	9242535 14499622
CDK1	FANCG	HPRD, BioGRID	empirical	15367677
CDK1	FEN1	HPRD, BioGRID	empirical	12853968
CDK1	CEP164	Reactome	predicted	12852856
CDK1	MAPRE1	Reactome	predicted	12852856
CDK1	NINL	Reactome	predicted	12852856
CDK1	AZI1	Reactome	predicted	12852856
CDK1	CEP152	Reactome	predicted	12852856
CDK1	SNRNP200	IntAct, BioGRID	empirical	20360068
CDK1	FOXM1	HPRD	empirical	15024056
CDK1	FOXO1	IntAct	empirical	18408765
CDK1	MPRIP	IntAct, BioGRID	empirical	20360068
CDK1	NUP210	HPRD	empirical	8672508
CDK1	CLASP1	Reactome	predicted	12852856
CDK1	SIRT1	IntAct	empirical	19107194
CDK1	FOLR1	IntAct, BioGRID	empirical	20360068
CDK1	ZNF281	BioGRID	empirical	17093407
CDK1	CORO1C	IntAct, BioGRID	empirical	20360068
CDK1	TRIM29	IntAct, BioGRID	empirical	20360068
CDK1	ABL1	HPRD	empirical	2183353
CDK1	FYN	HPRD	empirical	8910336
CDK1	C20orf4	IntAct, BioGRID	empirical	20360068
CDK1	PHGDH	IntAct	empirical	20360068
CDK1	GDI2	IntAct, BioGRID	empirical	20360068
CDK1	GFAP	HPRD	empirical	7822264 12177195
CDK1	AMPH	HPRD	empirical	11113134
CDK1	GNAI2	IntAct	empirical	20360068
CDK1	GNB1	IntAct, BioGRID	empirical	20360068
CDK1	GNB2	IntAct, BioGRID	empirical	20360068
CDK1	GOLGA2	HPRD	empirical	10769027 9753325
CDK1	SFN	HPRD, MINT, BioGRID	empirical	10524633
CDK1	RGCC	HPRD	empirical	11687586
CDK1	RACGAP1	MINT	empirical	18201571
CDK1	TMOD3	IntAct, BioGRID	empirical	20360068
CDK1	ANAPC2	IntAct	empirical	20360068
CDK1	CNOT7	HPRD, BioGRID	empirical	10602502
CDK1	EEF2K	MINT	empirical	18337751
CDK1	EPN1	HPRD	empirical	10764745
CDK1	ANAPC4	IntAct, BioGRID	empirical	20360068
CDK1	HIST1H1D	BioGRID	empirical	21131960
CDK1	HIST1H1A	BioGRID	empirical	9247342
CDK1	HDGF	IntAct	empirical	21907836
CDK1	ANXA4	IntAct, BioGRID	empirical	20360068
CDK1	HMGB1	BioGRID	empirical	2013279
CDK1	HMGA1	HPRD, IntAct	empirical	1939057 17960875
CDK1	HNRNPA1	IntAct	empirical	20360068
CDK1	HNRNPK	BioGRID	empirical	20360068
CDK1	HNRNPU	IntAct, BioGRID	empirical	20360068
CDK1	HSPA2	HPRD, BioGRID	empirical	9247342 19553603
CDK1	HSPA4	BioGRID	empirical	9247342
CDK1	BIRC5	HPRD, IntAct	empirical	11069302 11861764 17681274
CDK1	HSP90AA1	Reactome	predicted	12852856
CDK1	APLP2	HPRD	empirical	9109675
CDK1	IDE	IntAct, BioGRID	empirical	20360068
CDK1	KIF24	IntAct, BioGRID	empirical	20360068
CDK1	IL3RA	IntAct	empirical	21988832
CDK1	CXCR1	IntAct	empirical	21988832
CDK1	IL16	HPRD	empirical	12450396
CDK1	INCENP	IntAct	empirical	17681274
CDK1	AR	HPRD	empirical	12569365 9725910
CDK1	ITPR1	HPRD	empirical	14635192 16237118
CDK1	JAK3	IntAct	empirical	21988832
CDK1	ARF4	IntAct, BioGRID	empirical	20360068
CDK1	KIF11	HPRD	empirical	9235942 8548803
CDK1	KRT18	HPRD	empirical	9524113 15368451
CDK1	STMN1	HPRD	empirical	8376365 11135364 8325880
CDK1	LMNA	HPRD	empirical	7925482 2344612
CDK1	LMNB1	HPRD	empirical	11901153 8034666
CDK1	LYN	HPRD, BioGRID	empirical	8910336 8051175 8084605 10564259
CDK1	MAP4	HPRD, BioGRID	empirical	9398320 11683421 7876309
CDK1	MAPT	HPRD	empirical	9614189
CDK1	MCM4	HPRD	empirical	16519687
CDK1	MDM4	HPRD	empirical	15735705
CDK1	MEF2C	HPRD	empirical	16478538
CDK1	MGMT	BioGRID	empirical	16226712
CDK1	CIITA	BioGRID	empirical	18245089
CDK1	MKI67	BioGRID	empirical	10502411
CDK1	MNDA	HPRD	empirical	16458891
CDK1	MYC	HPRD, IntAct	empirical	1748630 17314511
CDK1	GADD45B	HPRD, BioGRID	empirical	10973963 12124778
CDK1	MYOD1	BioGRID	empirical	14749395
CDK1	PPP1R12A	IntAct, BioGRID	empirical	20360068
CDK1	MYT1	HPRD, IntAct	empirical	9001210 9268380
CDK1	NASP	BioGRID	empirical	19553603
CDK1	NEK2	Reactome	predicted	12852856
CDK1	NPM1	HPRD	empirical	12058066 11278991
CDK1	ODF2	Reactome	predicted	12852856
CDK1	PAFAH1B1	Reactome	predicted	12852856
CDK1	PCM1	Reactome	predicted	12852856
CDK1	PCNA	HPRD	empirical	7949095
CDK1	PCNT	Reactome	predicted	12852856
CDK1	CDK16	IntAct, BioGRID	empirical	20360068
CDK1	CDK17	IntAct, BioGRID	empirical	20360068
CDK1	ANAPC7	IntAct, BioGRID	empirical	20360068
CDK1	UIMC1	IntAct, BioGRID	empirical	19615732
CDK1	PGK1	IntAct, BioGRID	empirical	20360068
CDK1	SERPINB5	IntAct, BioGRID	empirical	20360068
CDK1	PIN1	HPRD	empirical	11774038
CDK1	PKM2	IntAct, BioGRID	empirical	20360068
CDK1	PLEC	HPRD	empirical	8626512
CDK1	PLK1	Reactome	predicted	12852856
CDK1	PML	IntAct	empirical	21840486
CDK1	POLA1	HPRD	empirical	11259605
CDK1	POU5F1	BioGRID	empirical	17093407
CDK1	PPIA	IntAct, BioGRID	empirical	20360068
CDK1	NDE1	HPRD, IntAct, Reactome	empirical	12556484 16682949 12852856
CDK1	NSUN2	IntAct, BioGRID	empirical	20360068
CDK1	PPL	IntAct, BioGRID	empirical	20360068
CDK1	PPP1CA	IntAct, BioGRID	empirical	17274640 20360068
CDK1	PPP1CC	IntAct	empirical	17274640
CDK1	CEP192	Reactome	predicted	12852856
CDK1	HAUS2	Reactome	predicted	12852856
CDK1	CEP55	HPRD, IntAct, BioGRID	empirical	16198290 20360068
CDK1	PPP2R1A	HPRD, IntAct, BioGRID, Reactome	empirical	17540176 12852856
CDK1	PPP2R1B	HPRD, IntAct, BioGRID	empirical	17540176
CDK1	PRKACA	Reactome	predicted	12852856
CDK1	CEP72	IntAct, BioGRID, Reactome	empirical	20360068 12852856
CDK1	CDK5RAP2	Reactome	predicted	12852856
CDK1	PRKAR2B	Reactome	predicted	12852856
CDK1	PRKCB	BioGRID	empirical	11901153
CDK1	CENPJ	Reactome	predicted	12852856
CDK1	PBK	HPRD, MINT	empirical	15541388 10779557
CDK1	MLL5	BioGRID	empirical	20439461
CDK1	NSFL1C	HPRD, BioGRID	empirical	12810701
CDK1	PAK6	IntAct	empirical	21988832
CDK1	PTCH1	HPRD	empirical	11331587
CDK1	BIRC6	HPRD, IntAct	empirical	18329369
CDK1	PTMA	HPRD	empirical	11310559
CDK1	PTPN1	HPRD	empirical	8491187 9600099
CDK1	PTPN2	HPRD	empirical	15030318
CDK1	PURA	BioGRID	empirical	15707957
CDK1	RAB4A	HPRD	empirical	1425574
CDK1	RAB5B	HPRD	empirical	10403367
CDK1	RAP1GAP	HPRD	empirical	1406653
CDK1	RB1	HPRD	empirical	1756735
CDK1	GNB4	IntAct, BioGRID	empirical	20360068
CDK1	BCL2	BioGRID	empirical	11774038 11326318
CDK1	RELB	IntAct	empirical	21988832
CDK1	RPA2	HPRD	empirical	1318195 9295339
CDK1	RPS6KB1	HPRD	empirical	12586835 9271440
CDK1	RRM2	HPRD	empirical	9990288
CDK1	RYK	BioGRID	empirical	21875946
CDK1	TSPYL2	BioGRID	empirical	11395479
CDK1	ANAPC1	IntAct, BioGRID	empirical	20360068
CDK1	GORASP1	HPRD	empirical	12839990
CDK1	SKP1	IntAct, BioGRID	empirical	20360068
CDK1	SKP2	IntAct, BioGRID	empirical	20360068
CDK1	ANXA8	IntAct, BioGRID	empirical	20360068
CDK1	SPRR2A	IntAct	empirical	20360068
CDK1	SPRR2B	IntAct, BioGRID	empirical	20360068
CDK1	SPRR2C	IntAct	empirical	20360068
CDK1	SPRR2D	BioGRID	empirical	20360068
CDK1	SPRR2E	IntAct, BioGRID	empirical	20360068
CDK1	SPRR2G	BioGRID	empirical	20360068
CDK1	SPTBN2	IntAct	empirical	20360068
CDK1	BRCA1	HPRD, BioGRID	empirical	9244350
CDK1	SSBP1	IntAct, BioGRID	empirical	20360068
CDK1	BRCA2	HPRD	empirical	15800651
CDK1	BSG	IntAct, BioGRID	empirical	20360068
CDK1	SVIL	IntAct, BioGRID	empirical	20360068
CDK1	BUB1	HPRD	empirical	16760428
CDK1	TGFBR2	HPRD	empirical	9926943
CDK1	TJP1	IntAct, BioGRID	empirical	20360068
CDK1	TK1	HPRD	empirical	9575153 14697231
CDK1	TLE1	HPRD	empirical	12397081
CDK1	TNNC1	IntAct	empirical	21988832
CDK1	TOP2A	HPRD	empirical	7635160 12569090
CDK1	TP53	HPRD, BioGRID	empirical	11327730 10884347
CDK1	TP73	HPRD	empirical	12676926
CDK1	TSC1	HPRD, BioGRID	empirical	11444800 14551205
CDK1	TUBA4A	Reactome	predicted	12852856
CDK1	TUBG1	Reactome	predicted	12852856
CDK1	UBC	BioGRID	empirical	18655026 16196087 18781797 21987572 21139048 21890473 21906983
CDK1	UBA1	HPRD	empirical	7724583 7673335
CDK1	UBE2A	HPRD	empirical	11953320
CDK1	VCP	IntAct, BioGRID	empirical	20360068
CDK1	EZR	IntAct, BioGRID	empirical	20360068
CDK1	VIM	HPRD	empirical	7983050 15345747
CDK1	WEE1	HPRD, IntAct, BioGRID	empirical	10564259 9268380 12186947 8428596 20360068
CDK1	YWHAG	Reactome	predicted	12852856
CDK1	CA2	IntAct, BioGRID	empirical	20360068
CDK1	ZBTB16	HPRD, BioGRID	empirical	10497277
CDK1	ALMS1	Reactome	predicted	12852856
CDK1	TUBA1A	Reactome	predicted	12852856
CDK1	AHNAK	IntAct, BioGRID	empirical	20360068
CDK1	CEP76	Reactome	predicted	12852856
CDK1	POF1B	BioGRID	empirical	20360068
CDK1	CALD1	HPRD	empirical	12613668
CDK1	CEP290	Reactome	predicted	12852856
CDK1	CEP63	Reactome	predicted	12852856
CDK1	CEP70	Reactome	predicted	12852856
CDK1	HMGA2	HPRD	empirical	10636877
CDK1	NDEL1	IntAct	empirical	16682949
CDK1	CDT1	HPRD, IntAct	empirical	14993212
CDK1	CHAF1B	HPRD	empirical	10938080
CDK1	CAPZA2	IntAct	empirical	20360068
CDK1	C11orf68	IntAct, BioGRID	empirical	20360068
CDK1	MAD1L1	IntAct, BioGRID	empirical	20360068
CDK1	CEP78	Reactome	predicted	12852856
CDK1	USP32	IntAct	empirical	19615732
CDK1	OFD1	Reactome	predicted	12852856
CDK1	USP45	IntAct, BioGRID	empirical	19615732
CDK1	RUNX2	HPRD	empirical	16407259
CDK1	RUNX1	BioGRID	empirical	21059642
CDK1	SSNA1	Reactome	predicted	12852856
CDK1	DYNLL1	Reactome	predicted	12852856
CDK1	CDC23	IntAct, BioGRID	empirical	20360068
CDK1	IQGAP1	IntAct, BioGRID	empirical	20360068
CDK1	CCNA2	HPRD, IntAct, BioGRID, Reactome	empirical	10924145 19592082 20360068 14681455 12853968 17679094 19483727
CDK1	CCNA1	HPRD, IntAct, BioGRID, Reactome	empirical	8565853 14681455 1628647
CDK1	CCNB1	HPRD, IntAct, BioGRID, Reactome	empirical	2570636 10362260 12612082 18408765 19879842 20360068 9001210 14681455 9891079 10973963 10716937 17679094 9247342 19553603 16784539 16159883 20228808 20367638 8440392 12411508 10827953 8119945 1717476 7799941 1828290 9670027 9679058 10395539 1384126
CDK1	CCNE1	HPRD, IntAct, BioGRID	empirical	1388288 19592082 9891079
CDK1	CCNF	BioGRID	empirical	10716937
CDK1	PKMYT1	HPRD, IntAct	empirical	10373560 10504341 9001210 9268380 12912980 20360068
CDK1	LATS1	HPRD, IntAct, BioGRID	empirical	9988268 12372621
CDK1	AIFM1	IntAct, BioGRID	empirical	20360068
CDK1	CCNB2	HPRD, IntAct, BioGRID, Reactome	empirical	9926943 20360068 14681455 1717476
CDK1	NEXN	IntAct, BioGRID	empirical	20360068
CDK1	AURKB	IntAct	empirical	17681274
CDK1	PTTG1	HPRD	empirical	10656688
CDK1	CD8A	IntAct	empirical	21988832
CDK1	SPECC1	IntAct, BioGRID	empirical	20360068
CDK1	PDLIM7	IntAct, BioGRID	empirical	20360068
CDK1	EFTUD2	IntAct, BioGRID	empirical	20360068
CDK1	SNRNP40	IntAct, BioGRID	empirical	20360068
CDK1	CEP41	Reactome	predicted	12852856
CDK1	KIF20B	HPRD	empirical	11470801
CDK1	PITPNM1	HPRD	empirical	15125835
CDK1	CEP135	Reactome	predicted	12852856
CDK1	ESPL1	IntAct, BioGRID	empirical	20360068
CDK1	CEP57	Reactome	predicted	12852856
CDK1	CCP110	Reactome	predicted	12852856
CDK1	KIAA0101	BioGRID	empirical	21628590
CDK1	DLGAP5	BioGRID	empirical	15145941
CDK1	CKAP5	Reactome	predicted	12852856
CDK1	SFI1	Reactome	predicted	12852856
CDK1	CDK1	HPRD, IntAct, BioGRID	empirical	17192257 20360068
CDK1	CDC25A	HPRD	empirical	12411508
CDK1	CDC25C	HPRD, IntAct, BioGRID	empirical	11836499 9585407 9733650 9268380 9141461 8440392 8119945 17349584 20360068 10864927
CDK1	CDC27	IntAct, BioGRID	empirical	20360068