CD81

Summary Top Help

Gene Description:

CD81 molecule; Cd81 molecule; CD81 antigen

Synonyms:

CVID6, S5.7, Tapa1, Tapa-1, TAPA1, TSPAN28, Cd81, Tspan28, CD81

Orthologs:

Human CD81 (protein-coding), Mouse Cd81 (protein-coding), Rat Cd81 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1 Rat: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Not assigned	Mouse	chr7:117936155..152524553	34.59	508

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm25	Rat	chr1:193831373..230411453	36.58	585

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:2397407..2418649 (21.24 kb) View in Genome Browser

(Mouse) NCBIM37 - chr7:150238644..150253839 (15.20 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:203327287..203343047 (15.76 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CD81:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CD81:

The CD81 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
CD81	CR2	BioGRID	empirical	1383329
CD81	CSNK2B	IntAct	empirical	21988832
CD81	HLA-B	IntAct	empirical	17353931
CD81	ITGA4	HPRD, BioGRID	empirical	10229664
CD81	ITGB1	BioGRID	empirical	10229664 12175627
CD81	JAK3	IntAct	empirical	21988832
CD81	KIT	HPRD, BioGRID	empirical	12036870
CD81	CD46	BioGRID	empirical	10741407
CD81	MYOC	HPRD	empirical	16289162
CD81	PTGFRN	HPRD, BioGRID	empirical	11087758 11278880
CD81	RBBP6	HPRD, BioGRID	empirical	18851979
CD81	SHC1	HPRD	empirical	14676841
CD81	TSPAN4	HPRD, BioGRID	empirical	9360996
CD81	TRAF6	IntAct	empirical	17353931
CD81	UBC	BioGRID	empirical	18713730 21139048 21890473 21906983
CD81	ZBTB16	HPRD, MINT, IntAct, BioGRID	empirical	16169070
CD81	RNF128	HPRD, BioGRID	empirical	18713730
CD81	INO80B	HPRD, MINT, IntAct, BioGRID	empirical	16169070
CD81	IFITM1	HPRD, BioGRID, Reactome	empirical	2398277
CD81	CD4	BioGRID	empirical	7636191
CD81	DLG5	HPRD, MINT, IntAct, BioGRID	empirical	16169070
CD81	CD9	HPRD, BioGRID	empirical	8630057 9804823
CD81	CD19	HPRD, BioGRID, Reactome	empirical	1383329 7636191 9804823
CD81	IGSF8	HPRD, BioGRID	empirical	11673522
CD81	CD63	BioGRID	empirical	16533950
CD81	CD81	HPRD, BioGRID	empirical	12437138

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 3

Biocarta: None available

Reactome: 1

NCI-Nature Pathway Interaction Database: 2

Gene Ontology: 19

Publications from PubMed Top Help

Publications: 232

Tetraspanins regulate the protrusive activities of cell membrane.
Bari R, Guo Q, Xia B, Zhang YH, Giesert EE, Levy S, Zheng JJ, Zhang XA
Biochem Biophys Res Commun. 2011
PubMed ID: 22079629
SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.
Draber P, Vonkova I, Stepanek O, Hrdinka M, Kucova M, Skopcova T, Otahal P, Angelisova P, Horejsi V, Yeung M, Weiss A, Brdicka T
Mol Cell Biol. 2011
PubMed ID: 21930792
Hepatitis C virus is primed by CD81 protein for low pH-dependent fusion.
Sharma NR, Mateu G, Dreux M, Grakoui A, Cosset FL, Melikyan GB
J Biol Chem. 2011
PubMed ID: 21737455
CD81 is essential for the re-entry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathway.
Lin KK, Rossi L, Boles NC, Hall BE, George TC, Goodell MA
PLoS Biol. 2011
PubMed ID: 21931533
CD81 is essential for the formation of membrane protrusions and regulates Rac1-activation in adhesion-dependent immune cell migration.
Quast T, Eppler F, Semmling V, Schild C, Homsi Y, Levy S, Lang T, Kurts C, Kolanus W
Blood. 2011
PubMed ID: 21677313
Tetraspanins CD9 and CD81 are molecular partners of trimeric FcɛRI on human antigen-presenting cells.
Peng WM, Yu CF, Kolanus W, Mazzocca A, Bieber T, Kraft S, Novak N
Allergy. 2011
PubMed ID: 21241315
Interacting regions of CD81 and two of its partners, EWI-2 and EWI-2wint, and their effect on hepatitis C virus infection.
Montpellier C, Tews BA, Poitrimole J, Rocha-Perugini V, D'Arienzo V, Potel J, Zhang XA, Rubinstein E, Dubuisson J, Cocquerel L
J Biol Chem. 2011
PubMed ID: 21343309
Structural characterization of CD81-Claudin-1 hepatitis C virus receptor complexes.
Bonander N, Jamshad M, Hu K, Farquhar MJ, Stamataki Z, Balfe P, McKeating JA, Bill RM
Biochem Soc Trans. 2011
PubMed ID: 21428935
Hepatitis C virus entry and the tetraspanin CD81.
Farquhar MJ, Harris HJ, McKeating JA
Biochem Soc Trans. 2011
PubMed ID: 21428934
The effects of a CD81 null mutation on retinal pigment epithelium in mice.
Pan Y, Geisert DF, Orr WE, Geisert EE
Neurochem Res. 2011
PubMed ID: 20882409
Expression of human factors CD81, claudin-1, scavenger receptor, and occludin in mouse hepatocytes does not confer susceptibility to HCV entry.
Hikosaka K, Noritake H, Kimura W, Sultana N, Sharkar MT, Tagawa Y, Uezato T, Kobayashi Y, Wakita T, Miura N
Biomed Res. 2011
PubMed ID: 21551950
Hepatitis C virus protects human B lymphocytes from Fas-mediated apoptosis via E2-CD81 engagement.
Chen Z, Zhu Y, Ren Y, Tong Y, Hua X, Zhu F, Huang L, Liu Y, Luo Y, Lu W, Zhao P, Qi Z
PLoS One. 2011
PubMed ID: 21526201
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF, Goddard KA, Barreto ML, Reis MG, Teixeira MG
Eur J Hum Genet. 2010
PubMed ID: 20588308
Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1.
Mohammad F, Mondal T, Guseva N, Pandey GK, Kanduri C
Development. 2010
PubMed ID: 20573698
Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
Lee KM, Baris D, Zhang Y, Hosgood HD, Menashe I, Yeager M, Zahm SH, Wang SS, Purdue MP, Chanock S, Zheng T, Rothman N, Lan Q
Am J Hematol. 2010
PubMed ID: 20568250
Claudin association with CD81 defines hepatitis C virus entry.
Harris HJ, Davis C, Mullins JG, Hu K, Goodall M, Farquhar MJ, Mee CJ, McCaffrey K, Young S, Drummer H, Balfe P, McKeating JA
J Biol Chem. 2010
PubMed ID: 20375010
Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL, Thio CL
J Infect Dis. 2010
PubMed ID: 20331378
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency.
van Zelm MC, Smet J, Adams B, Mascart F, Schandené L, Janssen F, Ferster A, Kuo CC, Levy S, van Dongen JJ, van der Burg M
J Clin Invest. 2010
PubMed ID: 20237408
Novel function of CD81 in controlling hepatitis C virus replication.
Zhang YY, Zhang BH, Ishii K, Liang TJ
J Virol. 2010
PubMed ID: 20089661
Upregulation of imprinted genes in mice: an insight into the intensity of gene expression and the evolution of genomic imprinting.
Zaitoun I, Downs KM, Rosa GJ, Khatib H
Epigenetics. 2010
PubMed ID: 20168089
CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas.
Luo RF, Zhao S, Tibshirani R, Myklebust JH, Sanyal M, Fernandez R, Gratzinger D, Marinelli RJ, Lu ZS, Wong A, Levy R, Levy S, Natkunam Y
Hum Pathol. 2010
PubMed ID: 20004001
Membrane-Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes.
Bartee E, Eyster CA, Viswanathan K, Mansouri M, Donaldson JG, Früh K
PLoS One. 2010
PubMed ID: 21151997
Male CD81 knockout genotype disrupts Mendelian distribution of offspring.
Mordica WJ, Gallagher RJ, Kennedy JL, Chapes SK
Comp Med. 2010
PubMed ID: 20579434
Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome.
Oh-McGinnis R, Bogutz AB, Lee KY, Higgins MJ, Lefebvre L
BMC Dev Biol. 2010
PubMed ID: 20459838
Tetraspanin CD81 is required for Listeria monocytogenes invasion.
Tham TN, Gouin E, Rubinstein E, Boucheix C, Cossart P, Pizarro-Cerda J
Infect Immun. 2010
PubMed ID: 19901060
Regulation of NK cell trafficking by CD81.
Krämer B, Schulte D, Körner C, Zwank C, Hartmann A, Michalk M, Söhne J, Langhans B, Nischalke HD, Coenen M, Möhl C, Vogt A, Hennenberg M, Sauerbruch T, Spengler U, Nattermann J
Eur J Immunol. 2009
PubMed ID: 19830727
Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients.
Segat L, Milanese M, Pirulli D, Trevisiol C, Lupo F, Salizzoni M, Amoroso A, Crovella S
J Gastroenterol Hepatol. 2009
PubMed ID: 19817957
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q
Occup Environ Med. 2009
PubMed ID: 19773279
Aberrant underexpression of CD81 in precursor B-cell acute lymphoblastic leukemia: utility in detection of minimal residual disease by flow cytometry.
Muzzafar T, Medeiros LJ, Wang SA, Brahmandam A, Thomas DA, Jorgensen JL
Am J Clin Pathol. 2009
PubMed ID: 19846809
Enhanced B cell activation in the absence of CD81.
Sanyal M, Fernandez R, Levy S
Int Immunol. 2009
PubMed ID: 19737782
Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling.
Zismanov V, Lishner M, Tartakover-Matalon S, Radnay J, Shapiro H, Drucker L
Br J Cancer. 2009
PubMed ID: 19755988
Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin.
Coffey GP, Rajapaksa R, Liu R, Sharpe O, Kuo CC, Krauss SW, Sagi Y, Davis RE, Staudt LM, Sharman JP, Robinson WH, Levy S
J Cell Sci. 2009
PubMed ID: 19654214
293 cells over-expressing human ADI1 and CD81 are permissive for serum-derived hepatitis C virus infection.
Cheng JC, Yeh YJ, Pai LM, Chang ML, Yeh CT
J Med Virol. 2009
PubMed ID: 19626614
Control of cell motility by interaction of gangliosides, tetraspanins, and epidermal growth factor receptor in A431 versus KB epidermoid tumor cells.
Park SY, Yoon SJ, Freire-de-Lima L, Kim JH, Hakomori SI
Carbohydr Res. 2009
PubMed ID: 19559406
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Common genetic variants in candidate genes and risk of familial lymphoid malignancies.
Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR
Br J Haematol. 2009
PubMed ID: 19573080
Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cells.
Weng J, Krementsov DN, Khurana S, Roy NH, Thali M
J Virol. 2009
PubMed ID: 19458002
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
CD81 expression on CD19+ peripheral blood lymphocytes is associated with chronic HCV disease and increased risk for HCV infection: a putative role for inflammatory cytokines.
D'Agosto G, Trento E, Nosotti L, Bordignon V, Battista M, Prignano G, Pimpinelli F, Biolcati G, Macrì A, Palamara G, Miglioresi L, Morrone A, Di Carlo A, Cordiali-Fei P, Ensoli F
J Biol Regul Homeost Agents. 2009
PubMed ID: 19828092
Mutation of juxtamembrane cysteines in the tetraspanin CD81 affects palmitoylation and alters interaction with other proteins at the cell surface.
Delandre C, Penabaz TR, Passarelli AL, Chapes SK, Clem RJ
Exp Cell Res. 2009
PubMed ID: 19328198
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Macrophage cell lines use CD81 in cell growth regulation.
Mordica WJ, Woods KM, Clem RJ, Passarelli AL, Chapes SK
In Vitro Cell Dev Biol Anim. 2009
PubMed ID: 19184252
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs.
Gottwein JM, Scheel TK, Jensen TB, Lademann JB, Prentoe JC, Knudsen ML, Hoegh AM, Bukh J
Hepatology. 2009
PubMed ID: 19148942
The association of CD81 with tetraspanin-enriched microdomains is not essential for Hepatitis C virus entry.
Rocha-Perugini V, Lavie M, Delgrange D, Canton J, Pillez A, Potel J, Lecoeur C, Rubinstein E, Dubuisson J, Wychowski C, Cocquerel L
BMC Microbiol. 2009
PubMed ID: 19476617
A role for CD81 on the late steps of HIV-1 replication in a chronically infected T cell line.
Grigorov B, Attuil-Audenis V, Perugi F, Nedelec M, Watson S, Pique C, Darlix JL, Conjeaud H, Muriaux D
Retrovirology. 2009
PubMed ID: 19284574
Endothelial CD81 is a marker of early human atherosclerotic plaques and facilitates monocyte adhesion.
Rohlena J, Volger OL, van Buul JD, Hekking LH, van Gils JM, Bonta PI, Fontijn RD, Post JA, Hordijk PL, Horrevoets AJ
Cardiovasc Res. 2009
PubMed ID: 18805782
RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1.
Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ
J Mol Biol. 2008
PubMed ID: 18851979
Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivo.
Meuleman P, Hesselgesser J, Paulson M, Vanwolleghem T, Desombere I, Reiser H, Leroux-Roels G
Hepatology. 2008
PubMed ID: 19030166
Identification of a residue in hepatitis C virus E2 glycoprotein that determines scavenger receptor BI and CD81 receptor dependency and sensitivity to neutralizing antibodies.
Grove J, Nielsen S, Zhong J, Bassendine MF, Drummer HE, Balfe P, McKeating JA
J Virol. 2008
PubMed ID: 18829747
HCV E2 protein binds directly to thyroid cells and induces IL-8 production: a new mechanism for HCV induced thyroid autoimmunity.
Akeno N, Blackard JT, Tomer Y
J Autoimmun. 2008
PubMed ID: 18799285
Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor.
Arduise C, Abache T, Li L, Billard M, Chabanon A, Ludwig A, Mauduit P, Boucheix C, Rubinstein E, Le Naour F
J Immunol. 2008
PubMed ID: 18981120
The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane.
Lineberry N, Su L, Soares L, Fathman CG
J Biol Chem. 2008
PubMed ID: 18713730
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice.
Takeda Y, He P, Tachibana I, Zhou B, Miyado K, Kaneko H, Suzuki M, Minami S, Iwasaki T, Goya S, Kijima T, Kumagai T, Yoshida M, Osaki T, Komori T, Mekada E, Kawase I
J Biol Chem. 2008
PubMed ID: 18662991
Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE.
Dijkstra S, Kooij G, Verbeek R, van der Pol SM, Amor S, Geisert EE, Dijkstra CD, van Noort JM, Vries HE
Neurobiol Dis. 2008
PubMed ID: 18586096
CD81 is a central regulator of cellular events required for hepatitis C virus infection of human hepatocytes.
Brazzoli M, Bianchi A, Filippini S, Weiner A, Zhu Q, Pizza M, Crotta S
J Virol. 2008
PubMed ID: 18579606
Coligation of the hepatitis C virus receptor CD81 with CD28 primes naive T lymphocytes to acquire type 2 effector function.
Serra A, Nuti S, Tavarini S, Sammicheli C, Rosa D, Saletti G, Soldaini E, Abrignani S, Wack A
J Immunol. 2008
PubMed ID: 18566382
Tetraspanin CD81-regulated cell motility plays a critical role in intrahepatic metastasis of hepatocellular carcinoma.
Mazzocca A, Liotta F, Carloni V
Gastroenterology. 2008
PubMed ID: 18466772
CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry.
Harris HJ, Farquhar MJ, Mee CJ, Davis C, Reynolds GM, Jennings A, Hu K, Yuan F, Deng H, Hubscher SG, Han JH, Balfe P, McKeating JA
J Virol. 2008
PubMed ID: 18337570
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice.
Pan Z, Sikandar S, Witherspoon M, Dizon D, Nguyen T, Benirschke K, Wiley C, Vrana P, Lipkin SM
Dev Dyn. 2008
PubMed ID: 18163532
G9a histone methyltransferase contributes to imprinting in the mouse placenta.
Wagschal A, Sutherland HG, Woodfine K, Henckel A, Chebli K, Schulz R, Oakey RJ, Bickmore WA, Feil R
Mol Cell Biol. 2008
PubMed ID: 18039842
Two distinct mechanisms of silencing by the KvDMR1 imprinting control region.
Shin JY, Fitzpatrick GV, Higgins MJ
EMBO J. 2008
PubMed ID: 18079696
High-level expression, single-step immunoaffinity purification and characterization of human tetraspanin membrane protein CD81.
Takayama H, Chelikani P, Reeves PJ, Zhang S, Khorana HG
PLoS ONE. 2008
PubMed ID: 18523555
The CD81 partner EWI-2wint inhibits hepatitis C virus entry.
Rocha-Perugini V, Montpellier C, Delgrange D, Wychowski C, Helle F, Pillez A, Drobecq H, Le Naour F, Charrin S, Levy S, Rubinstein E, Dubuisson J, Cocquerel L
PLoS ONE. 2008
PubMed ID: 18382656
Dissecting the role of putative CD81 binding regions of E2 in mediating HCV entry: putative CD81 binding region 1 is not involved in CD81 binding.
Rothwangl KB, Manicassamy B, Uprichard SL, Rong L
Virol J. 2008
PubMed ID: 18355410
Serum-derived hepatitis C virus infection of primary human hepatocytes is tetraspanin CD81 dependent.
Molina S, Castet V, Pichard-Garcia L, Wychowski C, Meurs E, Pascussi JM, Sureau C, Fabre JM, Sacunha A, Larrey D, Dubuisson J, Coste J, McKeating J, Maurel P, Fournier-Wirth C
J Virol. 2008
PubMed ID: 17942559
Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies.
Timpe JM, Stamataki Z, Jennings A, Hu K, Farquhar MJ, Harris HJ, Schwarz A, Desombere I, Roels GL, Balfe P, McKeating JA
Hepatology. 2008
PubMed ID: 17941058
Possible involvement of CD81 in acrosome reaction of sperm in mice.
Tanigawa M, Miyamoto K, Kobayashi S, Sato M, Akutsu H, Okabe M, Mekada E, Sakakibara K, Miyado M, Umezawa A, Miyado K
Mol Reprod Dev. 2008
PubMed ID: 17290409
Normal prion protein trafficking in cultured human erythroblasts.
Griffiths RE, Heesom KJ, Anstee DJ
Blood. 2007
PubMed ID: 17827389
The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells.
Abache T, Le Naour F, Planchon S, Harper F, Boucheix C, Rubinstein E
J Cell Biochem. 2007
PubMed ID: 17407154
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis.
Chang Y, Finnemann SC
J Cell Sci. 2007
PubMed ID: 17684062
Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus.
Ye J
PLoS Pathog. 2007
PubMed ID: 17784784
Human immunodeficiency virus type 1 assembly, budding, and cell-cell spread in T cells take place in tetraspanin-enriched plasma membrane domains.
Jolly C, Sattentau QJ
J Virol. 2007
PubMed ID: 17522207
Hepatitis C virus envelope glycoprotein E2 glycans modulate entry, CD81 binding, and neutralization.
Falkowska E, Kajumo F, Garcia E, Reinus J, Dragic T
J Virol. 2007
PubMed ID: 17507469
CD81 down-regulation on B cells is associated with the response to interferon-alpha-based treatment for chronic hepatitis C virus infection.
Chang LL, Cheng PN, Chen JS, Young KC
Antiviral Res. 2007
PubMed ID: 17194487
CD81, a cell cycle regulator, is a novel target for histone deacetylase inhibition in glioma cells.
Gensert JM, Baranova OV, Weinstein DE, Ratan RR
Neurobiol Dis. 2007
PubMed ID: 17481908
The roles of CD81 and glycosaminoglycans in the adsorption and uptake of infectious HCV particles.
Morikawa K, Zhao Z, Date T, Miyamoto M, Murayama A, Akazawa D, Tanabe J, Sone S, Wakita T
J Med Virol. 2007
PubMed ID: 17457918
CD81 expression is important for the permissiveness of Huh7 cell clones for heterogeneous hepatitis C virus infection.
Akazawa D, Date T, Morikawa K, Murayama A, Miyamoto M, Kaga M, Barth H, Baumert TF, Dubuisson J, Wakita T
J Virol. 2007
PubMed ID: 17329343
The inner loop of tetraspanins CD82 and CD81 mediates interactions with human T cell lymphotrophic virus type 1 Gag protein.
Mazurov D, Heidecker G, Derse D
J Biol Chem. 2007
PubMed ID: 17166843
The developmental regulation of CD81 in the rat retina.
Pan Y, Brown C, Wang X, Geisert EE
Mol Vis. 2007
PubMed ID: 17327823
A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA.
Green K, Lewis A, Dawson C, Dean W, Reinhart B, Chaillet JR, Reik W
Mamm Genome. 2007
PubMed ID: 17245608
Immunogenic and functional organization of hepatitis C virus (HCV) glycoprotein E2 on infectious HCV virions.
Keck ZY, Xia J, Cai Z, Li TK, Owsianka AM, Patel AH, Luo G, Foung SK
J Virol. 2007
PubMed ID: 17079294
The level of CD81 cell surface expression is a key determinant for productive entry of hepatitis C virus into host cells.
Koutsoudakis G, Herrmann E, Kallis S, Bartenschlager R, Pietschmann T
J Virol. 2007
PubMed ID: 17079281
Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo.
Lewis A, Green K, Dawson C, Redrup L, Huynh KD, Lee JT, Hemberger M, Reik W
Development. 2006
PubMed ID: 17021040
Tetraspanins CD9 and CD81 modulate HIV-1-induced membrane fusion.
Gordón-Alonso M, Yañez-Mó M, Barreiro O, Alvarez S, Muñoz-Fernández MA, Valenzuela-Fernández A, Sánchez-Madrid F
J Immunol. 2006
PubMed ID: 17015697
Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages.
Chertova E, Chertov O, Coren LV, Roser JD, Trubey CM, Bess JW, Sowder RC, Barsov E, Hood BL, Fisher RJ, Nagashima K, Conrads TP, Veenstra TD, Lifson JD, Ott DE
J Virol. 2006
PubMed ID: 16940516
Identification of conserved residues in the E2 envelope glycoprotein of the hepatitis C virus that are critical for CD81 binding.
Owsianka AM, Timms JM, Tarr AW, Brown RJ, Hickling TP, Szwejk A, Bienkowska-Szewczyk K, Thomson BJ, Patel AH, Ball JK
J Virol. 2006
PubMed ID: 16912317
Dynamics of CD81 expression on lymphocyte subsets during interferon-alpha-based antiviral treatment of patients with chronic hepatitis C.
Kronenberger B, Herrmann E, Hofmann WP, Wedemeyer H, Sester M, Mihm U, Ghaliai T, Zeuzem S, Sarrazin C
J Leukoc Biol. 2006
PubMed ID: 16735696
Role of integrins, tetraspanins, and ADAM proteins during the development of apoptotic bodies by spermatogenic cells.
Kierszenbaum AL, Rosselot C, Rivkin E, Tres LL
Mol Reprod Dev. 2006
PubMed ID: 16557522
Assembly of infectious HIV-1 in human epithelial and T-lymphoblastic cell lines.
Grigorov B, Arcanger F, Roingeard P, Darlix JL, Muriaux D
J Mol Biol. 2006
PubMed ID: 16682056
Mapping of tetraspanin-enriched microdomains that can function as gateways for HIV-1.
Nydegger S, Khurana S, Krementsov DN, Foti M, Thali M
J Cell Biol. 2006
PubMed ID: 16735575
The identification of myocilin-associated proteins in the human trabecular meshwork.
Fautsch MP, Vrabel AM, Johnson DH
Exp Eye Res. 2006
PubMed ID: 16289162
Cholesterol contributes to the organization of tetraspanin-enriched microdomains and to CD81-dependent infection by malaria sporozoites.
Silvie O, Charrin S, Billard M, Franetich JF, Clark KL, van Gemert GJ, Sauerwein RW, Dautry F, Boucheix C, Mazier D, Rubinstein E
J Cell Sci. 2006
PubMed ID: 16687736
Different domains of CD81 mediate distinct stages of hepatitis C virus pseudoparticle entry.
Bertaux C, Dragic T
J Virol. 2006
PubMed ID: 16641285
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
Nature. 2006
PubMed ID: 16554811
Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane.
Booth AM, Fang Y, Fallon JK, Yang JM, Hildreth JE, Gould SJ
J Cell Biol. 2006
PubMed ID: 16533950
Reduced fertility of female mice lacking CD81.
Rubinstein E, Ziyyat A, Prenant M, Wrobel E, Wolf JP, Levy S, Le Naour F, Boucheix C
Dev Biol. 2006
PubMed ID: 16380109
Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments.
Shoham T, Rajapaksa R, Kuo CC, Haimovich J, Levy S
Mol Cell Biol. 2006
PubMed ID: 16449649
CD9 controls the formation of clusters that contain tetraspanins and the integrin alpha 6 beta 1, which are involved in human and mouse gamete fusion.
Ziyyat A, Rubinstein E, Monier-Gavelle F, Barraud V, Kulski O, Prenant M, Boucheix C, Bomsel M, Wolf JP
J Cell Sci. 2006
PubMed ID: 16418227
Complete predicted three-dimensional structure of the facilitator transmembrane protein and hepatitis C virus receptor CD81: conserved and variable structural domains in the tetraspanin superfamily.
Seigneuret M
Biophys J. 2006
PubMed ID: 16352525
Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders.
Rosa D, Saletti G, De Gregorio E, Zorat F, Comar C, D'Oro U, Nuti S, Houghton M, Barnaba V, Pozzato G, Abrignani S
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16339892
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk.
Higashiyama S, Nanba D
Biochim Biophys Acta. 2005
PubMed ID: 16054021
Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells.
Abramova N, Charniga C, Goderie SK, Temple S
Dev Biol. 2005
PubMed ID: 15890332
Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells.
Machida K, Cheng KT, Pavio N, Sung VM, Lai MM
J Virol. 2005
PubMed ID: 15956553
Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Taniwaki T, Haruna K, Nakamura H, Sekimoto T, Oike Y, Imaizumi T, Saito F, Muta M, Soejima Y, Utoh A, Nakagata N, Araki M, Yamamura K, Araki K
Dev Growth Differ. 2005
PubMed ID: 15840001
Tetraspanin CD81 provides a costimulatory signal resulting in increased human immunodeficiency virus type 1 gene expression in primary CD4+ T lymphocytes through NF-kappaB, NFAT, and AP-1 transduction pathways.
Tardif MR, Tremblay MJ
J Virol. 2005
PubMed ID: 15767432
Determinants of CD81 dimerization and interaction with hepatitis C virus glycoprotein E2.
Drummer HE, Wilson KA, Poumbourios P
Biochem Biophys Res Commun. 2005
PubMed ID: 15670777
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes.
Umlauf D, Goto Y, Cao R, Cerqueira F, Wagschal A, Zhang Y, Feil R
Nat Genet. 2004
PubMed ID: 15516932
Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation.
Lewis A, Mitsuya K, Umlauf D, Smith P, Dean W, Walter J, Higgins M, Feil R, Reik W
Nat Genet. 2004
PubMed ID: 15516931
Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells.
Morelli AE, Larregina AT, Shufesky WJ, Sullivan ML, Stolz DB, Papworth GD, Zahorchak AF, Logar AJ, Wang Z, Watkins SC, Falo LD, Thomson AW
Blood. 2004
PubMed ID: 15284116
Binding of HCV E2 to CD81 induces RANTES secretion and internalization of CC chemokine receptor 5.
Nattermann J, Nischalke HD, Feldmann G, Ahlenstiel G, Sauerbruch T, Spengler U
J Viral Hepat. 2004
PubMed ID: 15500552
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Genomic analysis of mouse retinal development.
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
PLoS Biol. 2004
PubMed ID: 15226823
Association of HCV-related mixed cryoglobulinemia with specific mutational pattern of the HCV E2 protein and CD81 expression on peripheral B lymphocytes.
Hofmann WP, Herrmann E, Kronenberger B, Merkwirth C, Welsch C, Lengauer T, Zeuzem S, Sarrazin C
Blood. 2004
PubMed ID: 15294858
Diverse hepatitis C virus glycoproteins mediate viral infection in a CD81-dependent manner.
McKeating JA, Zhang LQ, Logvinoff C, Flint M, Zhang J, Yu J, Butera D, Ho DD, Dustin LB, Rice CM, Balfe P
J Virol. 2004
PubMed ID: 15280458
Hepatitis C virus glycoprotein E2 contains a membrane-proximal heptad repeat sequence that is essential for E1E2 glycoprotein heterodimerization and viral entry.
Drummer HE, Poumbourios P
J Biol Chem. 2004
PubMed ID: 15136562
CD81 is an entry coreceptor for hepatitis C virus.
Cormier EG, Tsamis F, Kajumo F, Durso RJ, Gardner JP, Dragic T
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15123813
CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner.
Clark KL, Oelke A, Johnson ME, Eilert KD, Simpson PC, Todd SC
J Biol Chem. 2004
PubMed ID: 14966136
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells.
Carloni V, Mazzocca A, Ravichandran KS
Oncogene. 2004
PubMed ID: 14676841
CD81 is required for hepatitis C virus glycoprotein-mediated viral infection.
Zhang J, Randall G, Higginbottom A, Monk P, Rice CM, McKeating JA
J Virol. 2004
PubMed ID: 14722300
The tetraspanin CD81 is necessary for partitioning of coligated CD19/CD21-B cell antigen receptor complexes into signaling-active lipid rafts.
Cherukuri A, Shoham T, Sohn HW, Levy S, Brooks S, Carter R, Pierce SK
J Immunol. 2004
PubMed ID: 14688345
The CD81 tetraspanin facilitates instantaneous leukocyte VLA-4 adhesion strengthening to vascular cell adhesion molecule 1 (VCAM-1) under shear flow.
Feigelson SW, Grabovsky V, Shamri R, Levy S, Alon R
J Biol Chem. 2003
PubMed ID: 14532283
Phage display selection on whole cells yields a small peptide specific for HCV receptor human CD81.
Cao J, Zhao P, Miao XH, Zhao LJ, Xue LJ, Qi Zt Z
Cell Res. 2003
PubMed ID: 14728804
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Role of complement-binding CD21/CD19/CD81 in enhancing human B cell protection from Fas-mediated apoptosis.
Mongini PK, Jackson AE, Tolani S, Fattah RJ, Inman JK
J Immunol. 2003
PubMed ID: 14607925
Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor.
Bartosch B, Vitelli A, Granier C, Goujon C, Dubuisson J, Pascale S, Scarselli E, Cortese R, Nicosia A, Cosset FL
J Biol Chem. 2003
PubMed ID: 12913001
The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment.
Shoham T, Rajapaksa R, Boucheix C, Rubinstein E, Poe JC, Tedder TF, Levy S
J Immunol. 2003
PubMed ID: 14530327
CD81-dependent binding of hepatitis C virus E1E2 heterodimers.
Cocquerel L, Kuo CC, Dubuisson J, Levy S
J Virol. 2003
PubMed ID: 12970454
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes.
Takeda Y, Tachibana I, Miyado K, Kobayashi M, Miyazaki T, Funakoshi T, Kimura H, Yamane H, Saito Y, Goto H, Yoneda T, Yoshida M, Kumagai T, Osaki T, Hayashi S, Kawase I, Mekada E
J Cell Biol. 2003
PubMed ID: 12796480
Identification of a lactoferrin-derived peptide possessing binding activity to hepatitis C virus E2 envelope protein.
Nozaki A, Ikeda M, Naganuma A, Nakamura T, Inudoh M, Tanaka K, Kato N
J Biol Chem. 2003
PubMed ID: 12522210
Analysis of the subcellular localization of hepatitis C virus E2 glycoprotein in live cells using EGFP fusion proteins.
Kien F, Abraham JD, Schuster C, Kieny MP
J Gen Virol. 2003
PubMed ID: 12604806
Temporal regulation of CD81 following retinal injury in the rat.
Song BK, Geisert GR, Vázquez-Chona F, Geisert EE
Neurosci Lett. 2003
PubMed ID: 12565133
Human CD81 directly enhances Th1 and Th2 cell activation, but preferentially induces proliferation of Th2 cells upon long-term stimulation.
Maecker HT
BMC Immunol. 2003
PubMed ID: 12597781
T cell costimulation by the hepatitis C virus envelope protein E2 binding to CD81 is mediated by Lck.
Soldaini E, Wack A, D'Oro U, Nuti S, Ulivieri C, Baldari CT, Abrignani S
Eur J Immunol. 2003
PubMed ID: 12645944
Structural characterization of peptide fragments from hCD81-LEL.
Dhanasekaran M, Baures PW, VanCompernolle S, Todd S, Prakash O
J Pept Res. 2003
PubMed ID: 12492902
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
In vitro binding of hepatitis C virus to CD81-positive and -negative human cell lines.
Sasaki M, Yamauchi K, Nakanishi T, Kamogawa Y, Hayashi N
J Gastroenterol Hepatol. 2003
PubMed ID: 12519228
Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity.
Silvie O, Rubinstein E, Franetich JF, Prenant M, Belnoue E, Rénia L, Hannoun L, Eling W, Levy S, Boucheix C, Mazier D
Nat Med. 2003
PubMed ID: 12483205
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Expression of human CD81 in transgenic mice does not confer susceptibility to hepatitis C virus infection.
Masciopinto F, Freer G, Burgio VL, Levy S, Galli-Stampino L, Bendinelli M, Houghton M, Abrignani S, Uematsu Y
Virology. 2002
PubMed ID: 12504561
Cutting edge: dynamic redistribution of tetraspanin CD81 at the central zone of the immune synapse in both T lymphocytes and APC.
Mittelbrunn M, Yáñez-Mó M, Sancho D, Ursa A, Sánchez-Madrid F
J Immunol. 2002
PubMed ID: 12471100
Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH.
Mahy NL, Perry PE, Bickmore WA
J Cell Biol. 2002
PubMed ID: 12473685
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Release and intercellular transfer of cell surface CD81 via microparticles.
Fritzsching B, Schwer B, Kartenbeck J, Pedal A, Horejsi V, Ott M
J Immunol. 2002
PubMed ID: 12421929
Increased brain size and glial cell number in CD81-null mice.
Geisert EE, Williams RW, Geisert GR, Fan L, Asbury AM, Maecker HT, Deng J, Levy S
J Comp Neurol. 2002
PubMed ID: 12357429
Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1.
Fitzpatrick GV, Soloway PD, Higgins MJ
Nat Genet. 2002
PubMed ID: 12410230
Identification of the hepatitis C virus E2 glycoprotein binding site on the large extracellular loop of CD81.
Drummer HE, Wilson KA, Poumbourios P
J Virol. 2002
PubMed ID: 12368358
Variation of hepatitis C virus load, hypervariable region 1 quasispecies and CD81 hepatocyte expression in hepatocellular carcinoma and adjacent non-cancerous liver.
Young KC, Lin PW, Hsiao WC, Chang TT, Chang YC, Wu HL
J Med Virol. 2002
PubMed ID: 12210407
Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop.
Kitadokoro K, Ponassi M, Galli G, Petracca R, Falugi F, Grandi G, Bolognesi M
Biol Chem. 2002
PubMed ID: 12437138
Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infection.
Hennig BJ, Hellier S, Frodsham AJ, Zhang L, Klenerman P, Knapp S, Wright M, Thomas HC, Thursz M, Hill AV
Genes Immun. 2002
PubMed ID: 12209363
Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration.
Mazzocca A, Carloni V, Sciammetta S, Cordella C, Pantaleo P, Caldini A, Gentilini P, Pinzani M
J Hepatol. 2002
PubMed ID: 12175627
Infertility of CD9-deficient mouse eggs is reversed by mouse CD9, human CD9, or mouse CD81; polyadenylated mRNA injection developed for molecular analysis of sperm-egg fusion.
Kaji K, Oda S, Miyazaki S, Kudo A
Dev Biol. 2002
PubMed ID: 12086470
C-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors.
Anzai N, Lee Y, Youn BS, Fukuda S, Kim YJ, Mantel C, Akashi M, Broxmeyer HE
Blood. 2002
PubMed ID: 12036870
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD
Science. 2002
PubMed ID: 12040188
Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses.
Deng J, Dekruyff RH, Freeman GJ, Umetsu DT, Levy S
Int Immunol. 2002
PubMed ID: 11978781
Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions.
Tseng CT, Klimpel GR
J Exp Med. 2002
PubMed ID: 11781364
Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein.
Crotta S, Stilla A, Wack A, D'Andrea A, Nuti S, D'Oro U, Mosca M, Filliponi F, Brunetto RM, Bonino F, Abrignani S, Valiante NM
J Exp Med. 2002
PubMed ID: 11781363
Retinal pigment epithelium of the rat express CD81, the target of the anti-proliferative antibody (TAPA).
Geisert EE, Abel HJ, Fan L, Geisert GR
Invest Ophthalmol Vis Sci. 2002
PubMed ID: 11773042
Complexes of tetraspanins with integrins: more than meets the eye.
Berditchevski F
J Cell Sci. 2001
PubMed ID: 11739647
EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.
Stipp CS, Kolesnikova TV, Hemler ME
J Biol Chem. 2001
PubMed ID: 11504738
PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins.
Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC
J Immunol. 2001
PubMed ID: 11673522
Microarray expression profiling of tissues from mice with uniparental duplications of chromosomes 7 and 11 to identify imprinted genes.
Choi JD, Underkoffler LA, Collins JN, Marchegiani SM, Terry NA, Beechey CV, Oakey RJ
Mamm Genome. 2001
PubMed ID: 11668390
Altered sensitivity of CD81-deficient mice to neurobehavioral effects of cocaine.
Michna L, Brenz Verca MS, Widmer DA, Chen S, Lee J, Rogove J, Zhou R, Tsitsikov E, Miescher GC, Dreyer JL, Wagner GC
Brain Res Mol Brain Res. 2001
PubMed ID: 11376857
The major CD9 and CD81 molecular partner. Identification and characterization of the complexes.
Charrin S, Le Naour F, Oualid M, Billard M, Faure G, Hanash SM, Boucheix C, Rubinstein E
J Biol Chem. 2001
PubMed ID: 11278880
CD81 regulates neuron-induced astrocyte cell-cycle exit.
Kelić S, Levy S, Suarez C, Weinstein DE
Mol Cell Neurosci. 2001
PubMed ID: 11273649
FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein.
Stipp CS, Orlicky D, Hemler ME
J Biol Chem. 2001
PubMed ID: 11087758
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs.
Kitadokoro K, Bordo D, Galli G, Petracca R, Falugi F, Abrignani S, Grandi G, Bolognesi M
EMBO J. 2001
PubMed ID: 11226150
The zebrafish fth1, slc3a2, men1, pc, fgf3 and cycd1 genes define two regions of conserved synteny between linkage group 7 and human chromosome 11q13.
Yoder JA, Litman GW
Gene. 2000
PubMed ID: 11167010
Hepatitis C virus envelope protein E2 binds to CD81 of tamarins.
Allander T, Forns X, Emerson SU, Purcell RH, Bukh J
Virology. 2000
PubMed ID: 11080483
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain.
Onyango P, Miller W, Lehoczky J, Leung CT, Birren B, Wheelan S, Dewar K, Feinberg AP
Genome Res. 2000
PubMed ID: 11076855
Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting.
Engemann S, Strödicke M, Paulsen M, Franck O, Reinhardt R, Lane N, Reik W, Walter J
Hum Mol Genet. 2000
PubMed ID: 11063728
Allergen-induced airway hyperreactivity is diminished in CD81-deficient mice.
Deng J, Yeung VP, Tsitoura D, DeKruyff RH, Umetsu DT, Levy S
J Immunol. 2000
PubMed ID: 11046035
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse.
Paulsen M, El-Maarri O, Engemann S, Strödicke M, Franck O, Davies K, Reinhardt R, Reik W, Walter J
Hum Mol Genet. 2000
PubMed ID: 10915772
Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family.
Enklaar T, Esswein M, Oswald M, Hilbert K, Winterpacht A, Higgins M, Zabel B, Prawitt D
Genomics. 2000
PubMed ID: 10903843
Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infection.
Meola A, Sbardellati A, Bruni Ercole B, Cerretani M, Pezzanera M, Ceccacci A, Vitelli A, Levy S, Nicosia A, Traboni C, McKeating J, Scarselli E
J Virol. 2000
PubMed ID: 10846074
Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and huma
Yatsuki H, Watanabe H, Hattori M, Joh K, Soejima H, Komoda H, Xin Z, Zhu X, Higashimoto K, Nishimura M, Kuratomi S, Sasaki H, Sakaki Y, Mukai T
DNA Res. 2000
PubMed ID: 10907850
Identification of amino acid residues in CD81 critical for interaction with hepatitis C virus envelope glycoprotein E2.
Higginbottom A, Quinn ER, Kuo CC, Flint M, Wilson LH, Bianchi E, Nicosia A, Monk PN, McKeating JA, Levy S
J Virol. 2000
PubMed ID: 10729140
CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans.
Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E
Eur J Immunol. 2000
PubMed ID: 10741407
Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal imprinted region of mouse chromosome 7.
Kato R, Shirohzu H, Yokomine T, Mizuno S, Mukai T, Sasaki H
DNA Res. 1999
PubMed ID: 10691133
Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance.
Tachibana I, Hemler ME
J Cell Biol. 1999
PubMed ID: 10459022
Exchangeable gene trap using the Cre/mutated lox system.
Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki M, Miura K, Araki M, Yamamura K
Cell Mol Biol (Noisy-le-grand). 1999
PubMed ID: 10512203
Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.
Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E
Biochem J. 1999
PubMed ID: 10229664
The imprinted domain in mouse distal Chromosome 7: reagents for mutagenesis and sequencing.
Day CD, Smilinich NJ, Fitzpatrick GV, deJong PJ, Shows TB, Higgins MJ
Mamm Genome. 1999
PubMed ID: 9922400
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Mechanism of imprinting on mouse distal chromosome 7.
Ainscough JF, John RM, Surani MA
Genet Res. 1998
PubMed ID: 10036981
CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82.
Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E
J Biol Chem. 1998
PubMed ID: 9804823
Binding of hepatitis C virus to CD81.
Pileri P, Uematsu Y, Campagnoli S, Galli G, Falugi F, Petracca R, Weiner AJ, Houghton M, Rosa D, Grandi G, Abrignani S
Science. 1998
PubMed ID: 9794763
Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5.
Paulsen M, Davies KR, Bowden LM, Villar AJ, Franck O, Fuermann M, Dean WL, Moore TF, Rodrigues N, Davies KE, Hu RJ, Feinberg AP, Maher ER, Reik W, Walter J
Hum Mol Genet. 1998
PubMed ID: 9618174
Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster.
Caspary T, Cleary MA, Baker CC, Guan XJ, Tilghman SM
Mol Cell Biol. 1998
PubMed ID: 9584186
CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses.
Maecker HT, Do MS, Levy S
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9482907
A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes.
Hu RJ, Lee MP, Connors TD, Johnson LA, Burn TC, Su K, Landes GM, Feinberg AP
Genomics. 1997
PubMed ID: 9403053
NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins.
Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME
J Biol Chem. 1997
PubMed ID: 9360996
Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6.
Berditchevski F, Chang S, Bodorova J, Hemler ME
J Biol Chem. 1997
PubMed ID: 9360995
Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice.
Tsitsikov EN, Gutierrez-Ramos JC, Geha RS
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9380722
Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81.
Miyazaki T, Müller U, Campbell KS
EMBO J. 1997
PubMed ID: 9250665
Normal lymphocyte development but delayed humoral immune response in CD81-null mice.
Maecker HT, Levy S
J Exp Med. 1997
PubMed ID: 9126932
Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY.
Szöllósi J, Horejsí V, Bene L, Angelisová P, Damjanovich S
J Immunol. 1996
PubMed ID: 8816400
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Astrocyte growth, reactivity, and the target of the antiproliferative antibody, TAPA.
Geisert EE, Yang L, Irwin MH
J Neurosci. 1996
PubMed ID: 8757260
CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma.
Radford KJ, Thorne RF, Hersey P
Biochem Biophys Res Commun. 1996
PubMed ID: 8630057
Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82.
Imai T, Kakizaki M, Nishimura M, Yoshie O
J Immunol. 1995
PubMed ID: 7636191
Mapping of the genes for four members of the transmembrane 4 superfamily: mouse Cd9, Cd63, Cd81, and Cd82.
Seldin MF, Rochelle JM, Tomlinson MG, Wright MD
Immunogenetics. 1995
PubMed ID: 7590978
Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression.
Nagira M, Imai T, Ishikawa I, Uwabe KI, Yoshie O
Cell Immunol. 1994
PubMed ID: 8039242
Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins.
Virtaneva KI, Emi N, Marken JS, Aruffo A, Jones C, Spurr NK, Schröder JP
Immunogenetics. 1994
PubMed ID: 8168850
Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes.
Matsumoto AK, Martin DR, Carter RH, Klickstein LB, Ahearn JM, Fearon DT
J Exp Med. 1993
PubMed ID: 7690834
The upregulation of a glial cell surface antigen at the astrocytic scar in the rat.
Irwin MH, Geisert EE
Neurosci Lett. 1993
PubMed ID: 8361649
The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.
Bradbury LE, Kansas GS, Levy S, Evans RL, Tedder TF
J Immunol. 1992
PubMed ID: 1383329
Expression of TAPA-1 in preimplantation mouse embryos.
Andria ML, Barsh GS, Levy S
Biochem Biophys Res Commun. 1992
PubMed ID: 1380797
A novel cell adhesion molecule, G-CAM, found on cultured rat glia.
Geisert EE, Murphy TP, Irwin MH, Larjava H
Neurosci Lett. 1991
PubMed ID: 1816505
Structure and membrane topology of TAPA-1.
Levy S, Nguyen VQ, Andria ML, Takahashi S
J Biol Chem. 1991
PubMed ID: 1860863
Genomic organization and chromosomal localization of the TAPA-1 gene.
Andria ML, Hsieh CL, Oren R, Francke U, Levy S
J Immunol. 1991
PubMed ID: 1650385
TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen.
Takahashi S, Doss C, Levy S, Levy R
J Immunol. 1990
PubMed ID: 2398277
TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins.
Oren R, Takahashi S, Doss C, Levy R, Levy S
Mol Cell Biol. 1990
PubMed ID: 1695320
A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner.
Bastian H, Gruss P
EMBO J. 1990
PubMed ID: 1971786

Model Organism Phenotype Links from MGI Top Help

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	Human	Mouse	Rat
Entrez Gene	975	12520	25621
EnsEMBL Gene(s)	ENSG00000110651 LRG_142	ENSMUSG00000037706	ENSRNOG00000020451
Unigene	Hs.54457	Mm.806	Rn.1975
Homologene	CD81	Cd81	Cd81
OMIM	186845	N/A	N/A
GeneCards	CD81	N/A	N/A
Beta Cell Genomics	DT.100040647 DT.100885965 DT.100885968 DT.120734601 DT.451059 DT.91978911 DT.92453568 DT.97856641	DT.536922 DT.97397252	N/A
Reactome	P60033	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	975	12520	25621

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