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MDC1

Gene Description:   mediator of DNA-damage checkpoint 1; mediator of DNA damage checkpoint 1 Synonyms:   AA413496, Mdc1, Nfbd1, KIAA0170, NFBD1, DKFZp781A0122, MDC1, 6820401C03, mKIAA0170, MGC166888 Orthologs:   Human MDC1 (protein-coding), Mouse Mdc1 (protein-coding), Rat Mdc1 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, Inparanoid, OrthoMCL Human-Rat: Inparanoid, OrthoMCL Mouse-Rat: Inparanoid, OrthoMCL Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
MHC	Human	chr6:29910021..33498585	3.59	688

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd24	Mouse	chr17:35340111..41438922	6.10	184

(Human) GRCh37 - chr6:30667584..30685666 (188 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr17:35978443..35996615 (18.17 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr20:3042953..3057607 (14.65 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas           no data no data no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for MDC1: The MDC1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs MDC1   RAD50   IntAct, BioGRID  empirical  12607005  14519663  12607003  MDC1   CENPC1   BioGRID  empirical  14578343  MDC1   CHEK2   HPRD  empirical  12607004  12551934  MDC1   CREBBP   HPRD  empirical  16051665  MDC1   CSNK2A1   MINT  empirical  18583988  MDC1   EP300   HPRD  empirical  16051665  MDC1   FANCD2   IntAct  empirical  12607005  MDC1   GATA4   BioGRID  empirical  14578343  MDC1   H2AFX   HPRD, IntAct, BioGRID, Reactome  empirical  14519663  12607005  18001825  18001824  15201865  MDC1   BIRC5   BioGRID  empirical  20394854  MDC1   MDM2   BioGRID  empirical  14578343  MDC1   MRE11A   IntAct  empirical  12607005  MDC1   NBN   HPRD, MINT, IntAct, BioGRID  empirical  12607005  18583988  18001824  19804756  14519663  12607003  15201865  20460517  MDC1   ATM   HPRD, IntAct  empirical  12607005  MDC1   ANAPC5   BioGRID  empirical  17827148  MDC1   UIMC1   BioGRID  empirical  21857162  MDC1   POLR2A   BioGRID  empirical  14578343  MDC1   TERF2IP   IntAct  empirical  15383534  MDC1   HDAC8   BioGRID  empirical  14578343  MDC1   USP28   HPRD, BioGRID  empirical  16901786  MDC1   BARD1   HPRD  empirical  12611903  MDC1   RAD51   BioGRID  empirical  16186822  MDC1   ANAPC1   BioGRID  empirical  17827148  MDC1   BRCA1   HPRD, IntAct, BioGRID  empirical  12607005  17525332  MDC1   TP53   HPRD, BioGRID  empirical  14519663  MDC1   TP53BP1   HPRD, IntAct, BioGRID  empirical  12607005  18986980  17925396  MDC1   UBC   BioGRID  empirical  18757370  MDC1   WRN   BioGRID  empirical  14578343  MDC1   MCPH1   BioGRID  empirical  16872911  MDC1   SMC1A   HPRD, IntAct  empirical  12607005  MDC1   HDAC10   BioGRID  empirical  14578343  MDC1   CDC16   BioGRID  empirical  17827148  MDC1   RNF8   HPRD, IntAct, BioGRID  empirical  18001825  18001824  18006705  MDC1   MDC1   HPRD  empirical  14519663  12607005  MDC1   CDC27   BioGRID  empirical  17827148

View all

KEGG Network: None available   None available.

Biocarta: None available   None available.

Reactome: 7   ATM mediated phosphorylation of repair proteins REACT_1924 ATM mediated response to DNA double-strand break REACT_204 DNA Repair REACT_216 Double-Strand Break Repair REACT_2054 Homologous Recombination Repair REACT_1874 Homologous recombination repair of replication-independent double-strand breaks REACT_1587 Recruitment of repair and signaling proteins to double-strand breaks REACT_97

NCI-Nature Pathway Interaction Database: 1   ATM pathway

Gene Ontology: 13   Double-strand break repair via homologous recombination GO:0000724 Protein binding GO:0005515 Intracellular GO:0005622 Nucleus GO:0005634 Nucleoplasm GO:0005654 Nucleolus GO:0005730 Focal adhesion GO:0005925 DNA repair GO:0006281 Double-strand break repair GO:0006302 Cell cycle GO:0007049 Protein C-terminus binding GO:0008022 Intra-S DNA damage checkpoint GO:0031573 FHA domain binding GO:0070975

	KEGG Network: None available
	Biocarta: None available
	Reactome: 7 ATM mediated phosphorylation of repair proteins REACT_1924 ATM mediated response to DNA double-strand break REACT_204 DNA Repair REACT_216 Double-Strand Break Repair REACT_2054 Homologous Recombination Repair REACT_1874 Homologous recombination repair of replication-independent double-strand breaks REACT_1587 Recruitment of repair and signaling proteins to double-strand breaks REACT_97
	NCI-Nature Pathway Interaction Database: 1 ATM pathway
	Gene Ontology: 13 Double-strand break repair via homologous recombination GO:0000724 Protein binding GO:0005515 Intracellular GO:0005622 Nucleus GO:0005634 Nucleoplasm GO:0005654 Nucleolus GO:0005730 Focal adhesion GO:0005925 DNA repair GO:0006281 Double-strand break repair GO:0006302 Cell cycle GO:0007049 Protein C-terminus binding GO:0008022 Intra-S DNA damage checkpoint GO:0031573 FHA domain binding GO:0070975

Publications: 118

• MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells.
  Ichijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH
  Genes Dev. 2011
  PubMed ID: 21536735
   
  
• MDC1 collaborates with TopBP1 in DNA replication checkpoint control.
  Wang J, Gong Z, Chen J
  J Cell Biol. 2011
  PubMed ID: 21482717
   
  
• Mediator of DNA damage checkpoint protein 1 (MDC1) expression as a prognostic marker for nodal recurrence in early-stage breast cancer patients treated with breast-conserving surgery and radiation therapy.
  Patel AN, Goyal S, Wu H, Schiff D, Moran MS, Haffty BG
  Breast Cancer Res Treat. 2011
  PubMed ID: 20521098
   
  
• MDC1 cleavage by caspase-3: a novel mechanism for inactivating the DNA damage response during apoptosis.
  Solier S, Pommier Y
  Cancer Res. 2011
  PubMed ID: 21148072
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy cantonese.
  Shen GP, Pan QH, Hong MH, Qin HD, Xu YF, Chen LZ, Feng QS, Jorgensen TJ, Shugart YY, Zeng YX, Jia WH
  Int J Cancer. 2010
  PubMed ID: 21077165
   
  
• MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1.
  Li X, Corsa CA, Pan PW, Wu L, Ferguson D, Yu X, Min J, Dou Y
  Mol Cell Biol. 2010
  PubMed ID: 20837706
   
  
• The viral oncoprotein tax sequesters DNA damage response factors by tethering MDC1 to chromatin.
  Belgnaoui SM, Fryrear KA, Nyalwidhe JO, Guo X, Semmes OJ
  J Biol Chem. 2010
  PubMed ID: 20729195
   
  
• Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.
  Ucisik-Akkaya E, Davis CF, Do TN, Morrison BA, Stemmer SM, Amadio WJ, Tevfik Dorak M
  Mol Hum Reprod. 2010
  PubMed ID: 20587610
   
  
• Growth inhibition, morphology change, and cell cycle alterations in NFBD1-depleted human esophageal cancer cells.
  Yang Z, Bu Y, Wang C, Liu G, Song F
  Mol Cell Biochem. 2010
  PubMed ID: 20364298
   
  
• Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest.
  Shibata A, Barton O, Noon AT, Dahm K, Deckbar D, Goodarzi AA, Löbrich M, Jeggo PA
  Mol Cell Biol. 2010
  PubMed ID: 20421415
   
  
• NFBD1/MDC1 participates in the regulation of G2/M transition in mammalian cells.
  Bu Y, Suenaga Y, Okoshi R, Sang M, Kubo N, Song F, Nakagawara A, Ozaki T
  Biochem Biophys Res Commun. 2010
  PubMed ID: 20529673
   
  
• Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response.
  Cha H, Lowe JM, Li H, Lee JS, Belova GI, Bulavin DV, Fornace AJ
  Cancer Res. 2010
  PubMed ID: 20460517
   
  
• Radiation-induced survivin nuclear accumulation is linked to DNA damage repair.
  Capalbo G, Dittmann K, Weiss C, Reichert S, Hausmann E, Rödel C, Rödel F
  Int J Radiat Oncol Biol Phys. 2010
  PubMed ID: 20394854
   
  
• CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response.
  Becherel OJ, Jakob B, Cherry AL, Gueven N, Fusser M, Kijas AW, Peng C, Katyal S, McKinnon PJ, Chen J, Epe B, Smerdon SJ, Taucher-Scholz G, Lavin MF
  Nucleic Acids Res. 2010
  PubMed ID: 20008512
   
  
• Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1.
  Campbell SJ, Edwards RA, Glover JN
  Structure. 2010
  PubMed ID: 20159462
   
  
• 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.
  Noon AT, Shibata A, Rief N, Löbrich M, Stewart GS, Jeggo PA, Goodarzi AA
  Nat Cell Biol. 2010
  PubMed ID: 20081839
   
  
• Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression.
  Townsend K, Mason H, Blackford AN, Miller ES, Chapman JR, Sedgwick GG, Barone G, Turnell AS, Stewart GS
  J Biol Chem. 2009
  PubMed ID: 19826003
   
  
• A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage.
  Lloyd J, Chapman JR, Clapperton JA, Haire LF, Hartsuiker E, Li J, Carr AM, Jackson SP, Smerdon SJ
  Cell. 2009
  PubMed ID: 19804756
   
  
• High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
  Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA
  PLoS Genet. 2009
  PubMed ID: 19851445
   
  
• Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.
  Marteijn JA, Bekker-Jensen S, Mailand N, Lans H, Schwertman P, Gourdin AM, Dantuma NP, Lukas J, Vermeulen W
  J Cell Biol. 2009
  PubMed ID: 19797077
   
  
• Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.
  McWilliams RR, Bamlet WR, de Andrade M, Rider DN, Couch FJ, Cunningham JM, Matsumoto ME, Rabe KG, Hammer TJ, Petersen GM
  Cancer Epidemiol Biomarkers Prev. 2009
  PubMed ID: 19690177
   
  
• Lysine acetylation targets protein complexes and co-regulates major cellular functions.
  Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
  Science. 2009
  PubMed ID: 19608861
   
  
• Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients.
  Pugh TJ, Keyes M, Barclay L, Delaney A, Krzywinski M, Thomas D, Novik K, Yang C, Agranovich A, McKenzie M, Morris WJ, Olive PL, Marra MA, Moore RA
  Clin Cancer Res. 2009
  PubMed ID: 19638463
   
  
• Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.
  Savic V, Yin B, Maas NL, Bredemeyer AL, Carpenter AC, Helmink BA, Yang-Iott KS, Sleckman BP, Bassing CH
  Mol Cell. 2009
  PubMed ID: 19450528
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.
  Ouyang J, Shi Y, Valin A, Xuan Y, Gill G
  Mol Cell. 2009
  PubMed ID: 19394292
   
  
• The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage.
  Eliezer Y, Argaman L, Rhie A, Doherty AJ, Goldberg M
  J Biol Chem. 2009
  PubMed ID: 18986980
   
  
• Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners.
  Montes de Oca R, Shoemaker CJ, Gucek M, Cole RN, Wilson KL
  PLoS One. 2009
  PubMed ID: 19759913
   
  
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
  Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
  Sci Signal. 2009
  PubMed ID: 19690332
   
  
• Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
  Enjuanes A, Benavente Y, Bosch F, Martín-Guerrero I, Colomer D, Pérez-Alvarez S, Reina O, Ardanaz MT, Jares P, García-Orad A, Pujana MA, Montserrat E, de Sanjosé S, Campo E
  Cancer Res. 2008
  PubMed ID: 19074885
   
  
• Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.
  Wang B, Malik R, Nigg EA, Körner R
  Anal Chem. 2008
  PubMed ID: 19007248
   
  
• NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway.
  Wilson KA, Stern DF
  Cell Cycle. 2008
  PubMed ID: 19001859
   
  
• Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation.
  Shi W, Ma Z, Willers H, Akhtar K, Scott SP, Zhang J, Powell S, Zhang J
  J Biol Chem. 2008
  PubMed ID: 18757370
   
  
• Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1.
  Stiff T, Cerosaletti K, Concannon P, O'Driscoll M, Jeggo PA
  Hum Mol Genet. 2008
  PubMed ID: 18664457
   
  
• Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
  Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
  Genome Res. 2008
  PubMed ID: 18799693
   
  
• Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites.
  Xu C, Wu L, Cui G, Botuyan MV, Chen J, Mer G
  J Mol Biol. 2008
  PubMed ID: 18582474
   
  
• MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks.
  Wu L, Luo K, Lou Z, Chen J
  Proc Natl Acad Sci U S A. 2008
  PubMed ID: 18678890
   
  
• A quantitative atlas of mitotic phosphorylation.
  Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
  Proc Natl Acad Sci U S A. 2008
  PubMed ID: 18669648
   
  
• Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage.
  Chapman JR, Jackson SP
  EMBO Rep. 2008
  PubMed ID: 18583988
   
  
• Differential regulation of centrosome integrity by DNA damage response proteins.
  Rai R, Phadnis A, Haralkar S, Badwe RA, Dai H, Li K, Lin SY
  Cell Cycle. 2008
  PubMed ID: 18635967
   
  
• NFBD1/MDC1 stabilizes oncogenic MDM2 to contribute to cell fate determination in response to DNA damage.
  Inoue K, Nakanjishi M, Kikuchi H, Yamamoto H, Todo S, Nakagawara A, Ozaki T
  Biochem Biophys Res Commun. 2008
  PubMed ID: 18471438
   
  
• Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis.
  Minter-Dykhouse K, Ward I, Huen MS, Chen J, Lou Z
  J Cell Biol. 2008
  PubMed ID: 18504301
   
  
• Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.
  Spycher C, Miller ES, Townsend K, Pavic L, Morrice NA, Janscak P, Stewart GS, Stucki M
  J Cell Biol. 2008
  PubMed ID: 18411308
   
  
• Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin.
  Melander F, Bekker-Jensen S, Falck J, Bartek J, Mailand N, Lukas J
  J Cell Biol. 2008
  PubMed ID: 18411307
   
  
• Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.
  Sivasubramaniam S, Sun X, Pan YR, Wang S, Lee EY
  Genes Dev. 2008
  PubMed ID: 18283122
   
  
• Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
  Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR
  J Proteome Res. 2008
  PubMed ID: 18220336
   
  
• Toward a confocal subcellular atlas of the human proteome.
  Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
  Mol Cell Proteomics. 2008
  PubMed ID: 18029348
   
  
• Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.
  Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y
  Anal Sci. 2008
  PubMed ID: 18187866
   
  
• Sp1-mediated transcriptional regulation of NFBD1/MDC1 plays a critical role in DNA damage response pathway.
  Bu Y, Suenaga Y, Ono S, Koda T, Song F, Nakagawara A, Ozaki T
  Genes Cells. 2008
  PubMed ID: 18173747
   
  
• Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.
  Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R
  Mol Cell. 2007
  PubMed ID: 18158901
   
  
• Changes in protein expression due to deleterious mutations in the FA/BRCA pathway.
  Salles D, Cabral RE, Paixão JC, de Almeida CE, Seuánez HN, Cabral-Neto JB
  Biochem Biophys Res Commun. 2007
  PubMed ID: 17977515
   
  
• Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.
  Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D
  Science. 2007
  PubMed ID: 18006705
   
  
• RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.
  Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J
  Cell. 2007
  PubMed ID: 18001825
   
  
• RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.
  Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J
  Cell. 2007
  PubMed ID: 18001824
   
  
• MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.
  Wood JL, Singh N, Mer G, Chen J
  J Biol Chem. 2007
  PubMed ID: 17925396
   
  
• DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours.
  Bartkova J, Horejsí Z, Sehested M, Nesland JM, Rajpert-De Meyts E, Skakkebaek NE, Stucki M, Jackson S, Lukas J, Bartek J
  Oncogene. 2007
  PubMed ID: 17546051
   
  
• The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome.
  Coster G, Hayouka Z, Argaman L, Strauss C, Friedler A, Brandeis M, Goldberg M
  J Biol Chem. 2007
  PubMed ID: 17827148
   
  
• Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
  Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD
  J Proteome Res. 2007
  PubMed ID: 17924679
   
  
• Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.
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• Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1.
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• Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
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• Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control.
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• NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage.
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• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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