CD40

Summary Top Help

Gene Description:

CD40 molecule, TNF receptor superfamily member 5; CD40 antigen

Synonyms:

TNFRSF5, TRAP, IMD3, AI326936, p50, CD40, IGM, Tnfrsf5, Bp50, CDW40, HIGM1, Cd40, T-BAM, GP39

Orthologs:

Human CD40 (protein-coding), Mouse Cd40 (protein-coding), Rat Cd40 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 1

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm13	Rat	chr3:131188558..163778754	32.59	406

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr20:44746906..44758502 (11.60 kb) View in Genome Browser

(Mouse) NCBIM37 - chr2:164881127..164898448 (17.32 kb) View in Genome Browser

(Rat) RGSC3.4 - chr3:156092602..156107427 (14.82 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CD40:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CD40:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 12

Biocarta: 6

Reactome: 1

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 34

Publications from PubMed Top Help

Type 1 Diabetes Publications: 19

Pancreatic islet derived stem cells can express co-stimulatory molecules of antigen-presenting cells.
Karaoz E, Okçu A, Saglam O, Genc ZS, Ayhan S, Kasap M
Transplant Proc. 2010
PubMed ID: 21094836
CD40 glycoforms and TNF-receptors 1 and 2 in the formation of CD40 receptor(s) in autoimmunity.
Vaitaitis GM, Wagner DH
Mol Immunol. 2010
PubMed ID: 20646763
CD40 expression and its association with low-grade inflammation in a Greek population of type 1 diabetic juveniles: evidence for differences in CD40 mRNA isoforms expressed by peripheral blood mononuclear cells.
Chatzigeorgiou AE, Lembessis PE, Mylona-Karagianni CF, Tsouvalas EA, Diamanti-Kandarakis E, Kamper EF
Exp Clin Endocrinol Diabetes. 2010
PubMed ID: 19834879
Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.
Fung EY, Smyth DJ, Howson JM, Cooper JD, Walker NM, Stevens H, Wicker LS, Todd JA
Genes Immun. 2009
PubMed ID: 19110536
CD40 on NOD CD4 T cells contributes to their activation and pathogenicity.
Baker RL, Wagner DH, Haskins K
J Autoimmun. 2008
PubMed ID: 18951762
N-acetylcysteine derivative inhibits CD40-dependent proinflammatory properties of human pancreatic duct cells.
Vosters O, Beuneu C, Goldman M, Verhasselt V
Pancreas. 2008
PubMed ID: 18437082
Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice.
Hamzah J, Nelson D, Moldenhauer G, Arnold B, Hämmerling GJ, Ganss R
J Clin Invest. 2008
PubMed ID: 18398504
CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity.
Calzascia T, Pellegrini M, Lin A, Garza KM, Elford AR, Shahinian A, Ohashi PS, Mak TW
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18287017
High distribution of CD40 and TRAF2 in Th40 T cell rafts leads to preferential survival of this auto-aggressive population in autoimmunity.
Vaitaitis GM, Wagner DH
PLoS ONE. 2008
PubMed ID: 18446238
Anti-CD40 conditioning enhances the T(CD8) response to a highly tolerogenic epitope and subsequent immunotherapy of simian virus 40 T antigen-induced pancreatic tumors.
Otahal P, Knowles BB, Tevethia SS, Schell TD
J Immunol. 2007
PubMed ID: 17982058
CD40 is required for development of islet inflammation in the RIP-CD154 transgenic mouse model of type 1 diabetes.
Haase C, Markholst H
Ann N Y Acad Sci. 2007
PubMed ID: 17804565
CD40-CD40 ligand interaction activates proinflammatory pathways in pancreatic islets.
Barbé-Tuana FM, Klein D, Ichii H, Berman DM, Coffey L, Kenyon NS, Ricordi C, Pastori RL
Diabetes. 2006
PubMed ID: 16936191
Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice.
Masaki H, Appel MC, Leahy L, Leif J, Paquin L, Shultz LD, Mordes JP, Greiner DL, Rossini AA
Xenotransplantation. 2006
PubMed ID: 16756565
A functional CD40 receptor is expressed in pancreatic beta cells.
Klein D, Barbé-Tuana F, Pugliese A, Ichii H, Garza D, Gonzalez M, Molano RD, Ricordi C, Pastori RL
Diabetologia. 2005
PubMed ID: 15690148
Role of CD40-CD154 pathway in the rejection of concordant and discordant xenogeneic islets.
Mai G, Bucher P, Morel P, Mei J, Bosco D, Andres A, Mathe Z, Wekerle T, Berney T, Bühler LH
Transplant Proc. 2005
PubMed ID: 15808676
CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells.
Serra P, Amrani A, Yamanouchi J, Han B, Thiessen S, Utsugi T, Verdaguer J, Santamaria P
Immunity. 2003
PubMed ID: 14670304
Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo.
Millar DG, Garza KM, Odermatt B, Elford AR, Ono N, Li Z, Ohashi PS
Nat Med. 2003
PubMed ID: 14625545
Cutting edge: CD40-induced expression of recombination activating gene (RAG) 1 and RAG2: a mechanism for the generation of autoaggressive T cells in the periphery.
Vaitaitis GM, Poulin M, Sanderson RJ, Haskins K, Wagner DH
J Immunol. 2003
PubMed ID: 12646605
Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity.
Hänninen A, Martinez NR, Davey GM, Heath WR, Harrison LC
J Clin Invest. 2002
PubMed ID: 11805138

Publications: 776

CD40 gene polymorphisms confer risk of Behcet's disease but not of Vogt-Koyanagi-Harada syndrome in a Han Chinese population.
Chen F, Hou S, Jiang Z, Chen Y, Kijlstra A, Rosenbaum JT, Yang P
Rheumatology (Oxford). 2012
PubMed ID: 22087016
Crucial role of CD40 signaling in vascular wall cells in neointimal formation and vascular remodeling after vascular interventions.
Song Z, Jin R, Yu S, Nanda A, Granger DN, Li G
Arterioscler Thromb Vasc Biol. 2012
PubMed ID: 21998133
Mechanisms of antigen presentation to T cells in murine graft-versus-host disease: cross-presentation and the appearance of cross-presentation.
Wang X, Li H, Matte-Martone C, Cui W, Li N, Tan HS, Roopenian D, Shlomchik WD
Blood. 2011
PubMed ID: 21963602
Intratumor OX40 stimulation inhibits IRF1 expression and IL-10 production by Treg cells while enhancing CD40L expression by effector memory T cells.
Burocchi A, Pittoni P, Gorzanelli A, Colombo MP, Piconese S
Eur J Immunol. 2011
PubMed ID: 22229156
A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis.
Vazgiourakis VM, Zervou MI, Choulaki C, Bertsias G, Melissourgaki M, Yilmaz N, Sidiropoulos P, Plant D, Trouw LA, Toes RE, Kardassis D, Yavuz S, Boumpas DT, Goulielmos GN
Ann Rheum Dis. 2011
PubMed ID: 21914625
Cutting edge: CD40-CD40 ligand pathway plays a critical CD8-intrinsic and -extrinsic role during rescue of exhausted CD8 T cells.
Bhadra R, Gigley JP, Khan IA
J Immunol. 2011
PubMed ID: 21949017
Hemolysin induces Toll-like receptor (TLR)-independent apoptosis and multiple TLR-associated parallel activation of macrophages.
Chakraborty DC, Mukherjee G, Banerjee P, Banerjee KK, Biswas T
J Biol Chem. 2011
PubMed ID: 21846723
In vivo therapeutic efficacy of intra-renal CD40 silencing in a model of humoral acute rejection.
Ripoll E, Pluvinet R, Torras J, Olivar R, Vidal A, Franquesa M, Cassis L, Cruzado JM, Bestard O, Grinyó JM, Aran JM, Herrero-Fresneda I
Gene Ther. 2011
PubMed ID: 21472009
Tyrosine nitration limits stretch-induced CD40 expression and disconnects CD40 signaling in human endothelial cells.
Wagner AH, Hildebrandt A, Baumgarten S, Jungmann A, Müller OJ, Sharov VS, Schöneich C, Hecker M
Blood. 2011
PubMed ID: 21832282
Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction.
Kastenmuller W, Gasteiger G, Subramanian N, Sparwasser T, Busch DH, Belkaid Y, Drexler I, Germain RN
J Immunol. 2011
PubMed ID: 21849683
Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation.
Ozcan E, Rauter I, Garibyan L, Dillon SR, Geha RS
J Allergy Clin Immunol. 2011
PubMed ID: 21741080
A CD40 and an NCOA5 gene polymorphism confer susceptibility to psoriasis in a Southern European population: a case-control study.
Zervou MI, Goulielmos GN, Castro-Giner F, Boumpas DT, Tosca AD, Krueger-Krasagakis S
Hum Immunol. 2011
PubMed ID: 21645569
Sensitization of SiHa cell to gemcitabine by CD40 activation and its overexpression in cervical carcinoma.
Huang Q, Qu QX, Xie F, Hu JM, Chen YG, Zhang XG
Med Oncol. 2011
PubMed ID: 20467921
Inhibitory Fcγ receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies.
Li F, Ravetch JV
Science. 2011
PubMed ID: 21852502
Complement regulates CD4 T-cell help to CD8 T cells required for murine allograft rejection.
Vieyra M, Leisman S, Raedler H, Kwan WH, Yang M, Strainic MG, Medof ME, Heeger PS
Am J Pathol. 2011
PubMed ID: 21704012
CD40 translocation to lipid rafts: signaling requirements and downstream biological events.
Nadiri A, Polyak MJ, Jundi M, Alturaihi H, Reyes-Moreno C, Hassan GS, Mourad W
Eur J Immunol. 2011
PubMed ID: 21567389
ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6.
Choi YS, Kageyama R, Eto D, Escobar TC, Johnston RJ, Monticelli L, Lao C, Crotty S
Immunity. 2011
PubMed ID: 21636296
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
CD40 stimulation sensitizes CLL cells to rituximab-induced cell death.
Jak M, van Bochove GG, van Lier RA, Eldering E, van Oers MH
Leukemia. 2011
PubMed ID: 21403646
CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection.
Srivastava N, Sudan R, Saha B
J Immunol. 2011
PubMed ID: 21471446
Prolonged antitumor NK cell reactivity elicited by CXCL10-expressing dendritic cells licensed by CD40L+ CD4+ memory T cells.
Shimizu K, Asakura M, Fujii S
J Immunol. 2011
PubMed ID: 21460206
Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk.
Liu X, Zhan Z, Li D, Xu L, Ma F, Zhang P, Yao H, Cao X
Nat Immunol. 2011
PubMed ID: 21441935
Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.
Mouri Y, Yano M, Shinzawa M, Shimo Y, Hirota F, Nishikawa Y, Nii T, Kiyonari H, Abe T, Uehara H, Izumi K, Tamada K, Chen L, Penninger JM, Inoue J, Akiyama T, Matsumoto M
J Immunol. 2011
PubMed ID: 21441458
Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow.
Simard N, Konforte D, Tran AH, Esufali J, Leonard WJ, Paige CJ
J Immunol. 2011
PubMed ID: 21430229
PPARγ expression is increased in systemic lupus erythematosus patients and represses CD40/CD40L signaling pathway.
Oxer DS, Godoy LC, Borba E, Lima-Salgado T, Passos LA, Laurindo I, Kubo S, Barbeiro DF, Fernandes D, Laurindo FR, Velasco IT, Curi R, Bonfa E, Souza HP
Lupus. 2011
PubMed ID: 21415255
Parenchymal expression of CD40 exacerbates adenovirus-induced hepatitis in mice.
Yan J, Jie Z, Hou L, Wanderley JL, Soong L, Gupta S, Qiu S, Chan T, Sun J
Hepatology. 2011
PubMed ID: 21360722
A composite MyD88/CD40 switch synergistically activates mouse and human dendritic cells for enhanced antitumor efficacy.
Narayanan P, Lapteva N, Seethammagari M, Levitt JM, Slawin KM, Spencer DM
J Clin Invest. 2011
PubMed ID: 21383499
Crystallographic and mutational analysis of the CD40-CD154 complex and its implications for receptor activation.
An HJ, Kim YJ, Song DH, Park BS, Kim HM, Lee JD, Paik SG, Lee JO, Lee H
J Biol Chem. 2011
PubMed ID: 21285457
CTSS activation coexists with CD40 activation in human atheroma: evidence from plasma mRNA analysis.
Cerne D, Stern I, Marc J, Cerne A, Zorman D, Krzisnik-Zorman S, Kranjec I
Clin Biochem. 2011
PubMed ID: 21223957
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans.
Beatty GL, Chiorean EG, Fishman MP, Saboury B, Teitelbaum UR, Sun W, Huhn RD, Song W, Li D, Sharp LL, Torigian DA, O'Dwyer PJ, Vonderheide RH
Science. 2011
PubMed ID: 21436454
Molecular mechanisms of TNFR-associated factor 6 (TRAF6) utilization by the oncogenic viral mimic of CD40, latent membrane protein 1 (LMP1).
Arcipowski KM, Stunz LL, Graham JP, Kraus ZJ, Vanden Bush TJ, Bishop GA
J Biol Chem. 2011
PubMed ID: 21262968
Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease.
Ferretti MT, Bruno MA, Ducatenzeiler A, Klein WL, Cuello AC
Neurobiol Aging. 2011
PubMed ID: 21414686
The CD40-CD154 interaction would correlate with proliferation and immune escape in pancreatic ductal adenocarcinoma.
Shoji Y, Miyamoto M, Ishikawa K, Yoshioka T, Mishra R, Ichinokawa K, Matsumura Y, Itoh T, Shinohara T, Hirano S, Kondo S
J Surg Oncol. 2011
PubMed ID: 21337550
Microvascular thrombosis and CD40/CD40L signaling.
Gavins FN, Li G, Russell J, Perretti M, Granger DN
J Thromb Haemost. 2011
PubMed ID: 21166993
The CD40 gene polymorphism rs1883832 is associated with risk of acute coronary syndrome in a Chinese case-control study.
Wang M, Li Y, Li W, Xia ZE, Wu Q
DNA Cell Biol. 2011
PubMed ID: 21091218
Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK.
Ha YJ, Seul HJ, Lee JR
Exp Mol Med. 2011
PubMed ID: 21200133
Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A.
Idoyaga J, Lubkin A, Fiorese C, Lahoud MH, Caminschi I, Huang Y, Rodriguez A, Clausen BE, Park CG, Trumpfheller C, Steinman RM
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21262813
The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas.
Knox PG, Davies CC, Ioannou M, Eliopoulos AG
J Cell Biol. 2011
PubMed ID: 21282461
Ileal immune dysregulation in necrotizing enterocolitis: role of CD40/CD40L in the pathogenesis of disease.
Xu J, Treem WR, Roman C, Anderson V, Rubenstein R, Schwarz SM
J Pediatr Gastroenterol Nutr. 2011
PubMed ID: 21240009
CD40 engagement on dendritic cells induces cyclooxygenase-2 and EP2 receptor via p38 and ERK MAPKs.
Harizi H, Limem I, Gualde N
Immunol Cell Biol. 2011
PubMed ID: 20697426
CD40-activated B cells contribute to mesothelioma tumor regression.
Jackaman C, Cornwall S, Graham PT, Nelson DJ
Immunol Cell Biol. 2011
PubMed ID: 20628372
CD40/CD40L interaction induces E-selectin dependent leukocyte adhesion to human endothelial cells and inhibits endothelial cell migration.
Urban D, Thanabalasingam U, Stibenz D, Kaufmann J, Meyborg H, Fleck E, Gräfe M, Stawowy P
Biochem Biophys Res Commun. 2011
PubMed ID: 21138731
CD40 polymorphisms in Han Chinese patients with Fuch uveitis syndrome.
Chen F, Hou S, Jiang Z, Li F, Chen Y, Kijlstra A, Yang P
Mol Vis. 2011
PubMed ID: 21976957
Association of CD40 gene polymorphisms with sporadic breast cancer in Chinese Han women of Northeast China.
Shuang C, Dalin L, Weiguang Y, Zhenkun F, Fengyan X, Da P, Li D
PLoS One. 2011
PubMed ID: 21912605
CD40 is essential in the upregulation of TRAF proteins and NF-kappaB-dependent proinflammatory gene expression after arterial injury.
Song Z, Jin R, Yu S, Rivet JJ, Smyth SS, Nanda A, Granger DN, Li G
PLoS One. 2011
PubMed ID: 21876738
HOIL-1L interacting protein (HOIP) is essential for CD40 signaling.
Hostager BS, Kashiwada M, Colgan JD, Rothman PB
PLoS One. 2011
PubMed ID: 21829693
Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice.
Poe JC, Smith SH, Haas KM, Yanaba K, Tsubata T, Matsushita T, Tedder TF
PLoS One. 2011
PubMed ID: 21799861
CD40 signaling synergizes with TLR-2 in the BCR independent activation of resting B cells.
Jain S, Chodisetti SB, Agrewala JN
PLoS One. 2011
PubMed ID: 21674065
Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L.
Kim DY, Hong GU, Ro JY
J Neuroinflammation. 2011
PubMed ID: 21410936
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells.
Li H, Matte-Martone C, Tan HS, Venkatesan S, McNiff J, Demetris AJ, Jain D, Lakkis F, Rothstein D, Shlomchik WD
J Immunol. 2011
PubMed ID: 21098219
Increased adipose tissue expression of proinflammatory CD40, MKK4 and JNK in patients with very severe chronic obstructive pulmonary disease.
Tkacova R, Ukropec J, Skyba P, Ukropcova B, Pobeha P, Kurdiova T, Joppa P, Klimes I, Tkac I, Gasperikova D
Respiration. 2011
PubMed ID: 20699612
Different molecular behavior of CD40 mutants causing hyper-IgM syndrome.
Lanzi G, Ferrari S, Vihinen M, Caraffi S, Kutukculer N, Schiaffonati L, Plebani A, Notarangelo LD, Fra AM, Giliani S
Blood. 2010
PubMed ID: 20702779
Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway.
Yacoub D, Hachem A, Théorêt JF, Gillis MA, Mourad W, Merhi Y
Arterioscler Thromb Vasc Biol. 2010
PubMed ID: 21071692
Differential TRAF3 utilization by a variant human CD40 receptor with enhanced signaling.
Peters AL, Bishop GA
J Immunol. 2010
PubMed ID: 21041727
Inhibition of terminal differentiation of B cells mediated by CD27 and CD40 involves signaling through JNK.
Satpathy S, Shenoy GN, Kaw S, Vaidya T, Bal V, Rath S, George A
J Immunol. 2010
PubMed ID: 20974987
Impact of residual renal function and HCV seropositivity on plasma CD40/CD40L system and oxidative status in haemodialysis patients.
Pawlak K, Mysliwiec M, Pawlak D
Clin Biochem. 2010
PubMed ID: 20846521
Association analysis of CD40 gene polymorphism with acute coronary syndrome.
Yan J, Wang C, Du R, Liu P, Chen G
Clin Exp Med. 2010
PubMed ID: 20127135
Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis.
Lievens D, Zernecke A, Seijkens T, Soehnlein O, Beckers L, Munnix IC, Wijnands E, Goossens P, van Kruchten R, Thevissen L, Boon L, Flavell RA, Noelle RJ, Gerdes N, Biessen EA, Daemen MJ, Heemskerk JW, Weber C, Lutgens E
Blood. 2010
PubMed ID: 20705757
Analysis of Immune Regulatory Genes' Copy Number Variants in Graves' Disease.
Huber AK, Concepcion ES, Gandhi A, Menconi F, Smith EP, Keddache M, Tomer Y
Thyroid. 2010
PubMed ID: 21054240
Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses.
Wiesel M, Joller N, Ehlert AK, Crouse J, Spörri R, Bachmann MF, Oxenius A
J Immunol. 2010
PubMed ID: 20881183
Dual roles of CD40 on microbial containment and the development of immunopathology in response to persistent fungal infection in the lung.
Chen GH, Osterholzer JJ, Choe MY, McDonald RA, Olszewski MA, Huffnagle GB, Toews GB
Am J Pathol. 2010
PubMed ID: 20864680
Lycorine sensitizes CD40 ligand-protected chronic lymphocytic leukemia cells to bezafibrate- and medroxyprogesterone acetate-induced apoptosis but dasatanib does not overcome reported CD40-mediated drug resistance.
Hayden RE, Pratt G, Drayson MT, Bunce CM
Haematologica. 2010
PubMed ID: 20634492
Blocking the CD40-CD40L interaction by CD40-Ig reduces disease progress in murine myocarditis induced by CVB3.
Bo H, Zhenhu L, Lijian Z
Cardiovasc Pathol. 2010
PubMed ID: 19914091
Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans.
Hughes LB, Reynolds RJ, Brown EE, Kelley JM, Thomson B, Conn DL, Jonas BL, Westfall AO, Padilla MA, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Plenge RM, Bridges SL
Arthritis Rheum. 2010
PubMed ID: 20973039
Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies.
Horton HM, Bernett MJ, Peipp M, Pong E, Karki S, Chu SY, Richards JO, Chen H, Repp R, Desjarlais JR, Zhukovsky EA
Blood. 2010
PubMed ID: 20616215
House dust mite regulate the lung inflammation of asthmatic mice through TLR4 pathway in airway epithelial cells.
Hongjia L, Qingling G, Meiying L, Weixuan W, Lihong Z, Yongsheng G, Yanli L, Jinxiang W, Liang D
Cell Biochem Funct. 2010
PubMed ID: 20941750
CD40 expression by human melanocytic lesions and melanoma cell lines and direct CD40 targeting with the therapeutic anti-CD40 antibody CP-870,893.
Kalbasi A, Fonsatti E, Natali PG, Altomonte M, Bertocci E, Cutaia O, Calabrò L, Chiou M, Tap W, Chmielowski B, Maio M, Ribas A
J Immunother. 2010
PubMed ID: 20842056
Latent membrane protein 1, the EBV-encoded oncogenic mimic of CD40, accelerates autoimmunity in B6.Sle1 mice.
Peters AL, Stunz LL, Meyerholz DK, Mohan C, Bishop GA
J Immunol. 2010
PubMed ID: 20810985
Influence of CD40 rs1883832 polymorphism in susceptibility to and clinical manifestations of biopsy-proven giant cell arteritis.
Rodríguez-Rodríguez L, Castañeda S, Vázquez-Rodríguez TR, Morado IC, Marí-Alfonso B, Gómez-Vaquero C, Miranda-Filloy JA, Narvaez J, Ortego-Centeno N, Blanco R, Fernández-Gutiérrez B, Martín J, González-Gay MA
J Rheumatol. 2010
PubMed ID: 20682661
Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans.
Lewis JP, Palmer ND, Ellington JB, Divers J, Ng MC, Lu L, Langefeld CD, Freedman BI, Bowden DW
Genomics. 2010
PubMed ID: 20650312
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Heligmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity.
Hang L, Setiawan T, Blum AM, Urban J, Stoyanoff K, Arihiro S, Reinecker HC, Weinstock JV
J Immunol. 2010
PubMed ID: 20702728
Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.
Chang JS, Wiemels JL, Chokkalingam AP, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Green J, May SL, Kiley VA, Wiencke JK, Buffler PA
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20716621
CD40 is a potential marker of favorable prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapy.
Rydström K, Linderoth J, Nyman H, Ehinger M, Joost P, Bendahl PO, Leppä S, Jerkeman M
Leuk Lymphoma. 2010
PubMed ID: 20593977
Genetic variants in the prediction of rheumatoid arthritis.
van der Helm-van Mil AH, Toes RE, Huizinga TW
Ann Rheum Dis. 2010
PubMed ID: 20439292
The expression of intercellular adhesion molecule-1 induced by CD40-CD40L ligand signaling in orbital fibroblasts in patients with Graves' ophthalmopathy.
Zhao LQ, Wei RL, Cheng JW, Cai JP, Li Y
Invest Ophthalmol Vis Sci. 2010
PubMed ID: 20107176
Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.
Deenick EK, Chan A, Ma CS, Gatto D, Schwartzberg PL, Brink R, Tangye SG
Immunity. 2010
PubMed ID: 20691615
Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1.
Sundqvist J, Falconer H, Seddighzadeh M, Vodolazkaia A, Fassbender A, Kyama C, Bokor A, Stephansson O, Padyukov L, Gemzell-Danielsson K, D'Hooghe TM
Fertil Steril. 2010
PubMed ID: 20797713
Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses.
Kurche JS, Burchill MA, Sanchez PJ, Haluszczak C, Kedl RM
J Immunol. 2010
PubMed ID: 20639485
Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
Lee KM, Baris D, Zhang Y, Hosgood HD, Menashe I, Yeager M, Zahm SH, Wang SS, Purdue MP, Chanock S, Zheng T, Rothman N, Lan Q
Am J Hematol. 2010
PubMed ID: 20568250
Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers.
Plant D, Flynn E, Mbarek H, Dieudé P, Cornelis F, Arlestig L, Dahlqvist SR, Goulielmos G, Boumpas DT, Sidiropoulos P, Johansen JS, Ørnbjerg LM, Hetland ML, Klareskog L, Filer A, Buckley CD, Raza K, Witte T, Schmidt RE, Worthington J
Ann Rheum Dis. 2010
PubMed ID: 20498205
Association between serum levels of soluble CD40/CD40 ligand and organ damage in hypertensive patients.
Yuan M, Ohishi M, Wang L, Raguki H, Wang H, Tao L, Ren J
Clin Exp Pharmacol Physiol. 2010
PubMed ID: 20456428
CD40 expression levels modulate regulatory T cells in Leishmania donovani infection.
Martin S, Agarwal R, Murugaiyan G, Saha B
J Immunol. 2010
PubMed ID: 20525887
Augmented antibody response with premature germinal center regression in CD40L transgenic mice.
Kishi Y, Aiba Y, Higuchi T, Furukawa K, Tokuhisa T, Takemori T, Tsubata T
J Immunol. 2010
PubMed ID: 20505144
Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas.
Bolduc A, Long E, Stapler D, Cascalho M, Tsubata T, Koni PA, Shimoda M
J Immunol. 2010
PubMed ID: 20505142
Gene-gene interaction between CD40 and CD40L reduces bone mineral density and increases osteoporosis risk in women.
Pineda B, Tarín JJ, Hermenegildo C, Laporta P, Cano A, García-Pérez MA
Osteoporos Int. 2010
PubMed ID: 20577873
The relationship between CD40 gene polymorphism and unstable coronary atherosclerotic plaques.
Wang C, Yan J, Yang P, Du R, Chen G
Clin Cardiol. 2010
PubMed ID: 20552594
The sequential expression of CD40 and Icam2 defines progressive steps in the formation of blood precursors from the mesoderm germ layer.
Pearson S, Lancrin C, Lacaud G, Kouskoff V
Stem Cells. 2010
PubMed ID: 20506544
CD40-1C>T polymorphism (rs1883832) is associated with brain vessel reocclusion after fibrinolysis in ischemic stroke.
del Río-Espínola A, Fernández-Cadenas I, Rubiera M, Quintana M, Domingues-Montanari S, Mendióroz M, Fernández-Morales J, Giralt D, Molina CA, Alvarez-Sabín J, Montaner J
Pharmacogenomics. 2010
PubMed ID: 20504251
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R
Pediatr Pulmonol. 2010
PubMed ID: 20503287
Loss of CD40 endogenous S-nitrosylation during inflammatory response in endotoxemic mice and patients with sepsis.
Godoy LC, Moretti AI, Jurado MC, Oxer D, Janiszewski M, Ckless K, Velasco IT, Laurindo FR, Souza HP
Shock. 2010
PubMed ID: 20473113
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FA, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Brouwer E, Burtt NP, Catanese JJ, Coblyn J, Coenen MJ, Costenbader KH, Criswell LA, Crusius JB, Cui J, de Bakker PI, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Lee AT, Liu X, Martin P, Morgan AW, Padyukov L, Posthumus MD, Radstake TR, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, van der Schoot CE, van Riel PL, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth BP, YEAR Consortium, Wijmenga C, Karlson EW, Toes RE, de Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM
Nat Genet. 2010
PubMed ID: 20453842
Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.
Tan RJ, Gibbons LJ, Potter C, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, BRAGGSS, Barton A
Ann Rheum Dis. 2010
PubMed ID: 20444755
Treatment of autoimmune arthritis using RNA interference-modulated dendritic cells.
Zheng X, Suzuki M, Ichim TE, Zhang X, Sun H, Zhu F, Shunnar A, Garcia B, Inman RD, Min W
J Immunol. 2010
PubMed ID: 20435931
CD40 -1C>T single nucleotide polymorphism and CD40 expression on breast tumors.
Dolen Y, Yilmaz G, Esendagli G, Guler NE, Guc D
Cytokine. 2010
PubMed ID: 20371189
The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis.
Gandhi KS, McKay FC, Cox M, Riveros C, Armstrong N, Heard RN, Vucic S, Williams DW, Stankovich J, Brown M, Danoy P, Stewart GJ, Broadley S, Moscato P, Lechner-Scott J, Scott RJ, Booth DR, ANZgene Multiple Sclerosis Genetics Consortium
Hum Mol Genet. 2010
PubMed ID: 20190274
Flow cytometric investigation of CD40-CD40 ligand system in preeclampsia and normal pregnancy.
Lukanov TH, Bojinova SI, Popova VS, Emin AL, Veleva GL, Gecheva SP, Konova EI
Clin Appl Thromb Hemost. 2010
PubMed ID: 19221099
CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells.
Nesbeth YC, Martinez DG, Toraya S, Scarlett UK, Cubillos-Ruiz JR, Rutkowski MR, Conejo-Garcia JR
J Immunol. 2010
PubMed ID: 20400704
CD40 signaling in CD8+CD40+ T cells turns on contra-T regulatory cell functions.
Martin S, Pahari S, Sudan R, Saha B
J Immunol. 2010
PubMed ID: 20400702
Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.
Hinks A, Eyre S, Ke X, Barton A, Martin P, Flynn E, Packham J, Childhood Arthritis Prospective Study (CAPS), UKRAG Consortium, BSPAR Study Group, Worthington J, Thomson W
Ann Rheum Dis. 2010
PubMed ID: 19674979
CD40 is a regulator for vascular endothelial growth factor in the tumor microenvironment of glioma.
Xie F, Shi Q, Wang Q, Ge Y, Chen Y, Zuo J, Gu Y, Deng H, Mao H, Hu Z, Zhou Y, Zhang X
J Neuroimmunol. 2010
PubMed ID: 20303602
Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study.
Orozco G, Eyre S, Hinks A, Ke X, Wellcome Trust Case Control consortium YEAR Consortium, Wilson AG, Bax DE, Morgan AW, Emery P, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Thomson W, Barton A, Worthington J
Ann Rheum Dis. 2010
PubMed ID: 19435719
A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis.
Nieters A, Bracci PM, de Sanjosé S, Becker N, Maynadié M, Benavente Y, Foretova L, Cocco P, Staines A, Holly EA, Boffetta P, Brennan P, Skibola CF
Int J Cancer. 2010
PubMed ID: 20473910
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
T cell-independent IgA class switch recombination is restricted to the GALT and occurs prior to manifest germinal center formation.
Bergqvist P, Stensson A, Lycke NY, Bemark M
J Immunol. 2010
PubMed ID: 20207993
The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease.
Borcherding F, Nitschke M, Hundorfean G, Rupp J, von Smolinski D, Bieber K, van Kooten C, Lehnert H, Fellermann K, Büning J
Am J Pathol. 2010
PubMed ID: 20133813
Differences in innate immune responses correlate with differences in murine susceptibility to Chlamydia muridarum pulmonary infection.
Jiang X, Shen C, Yu H, Karunakaran KP, Brunham RC
Immunology. 2010
PubMed ID: 20102413
A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis.
Wieczorek S, Holle JU, Müller S, Fricke H, Gross WL, Epplen JT
J Mol Med. 2010
PubMed ID: 20049410
MS80, a novel sulfated polysaccharide, inhibits CD40-NF-kappaB pathway via targeting RIP2.
Du X, Jiang S, Liu H, Xin X, Li J, Geng M, Jiang H
Mol Cell Biochem. 2010
PubMed ID: 19911254
Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.
Karlson EW, Chibnik LB, Kraft P, Cui J, Keenan BT, Ding B, Raychaudhuri S, Klareskog L, Alfredsson L, Plenge RM
Ann Rheum Dis. 2010
PubMed ID: 20233754
The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register.
Plant D, Thomson W, Lunt M, Flynn E, Martin P, Eyre S, Farragher T, Bunn D, Worthington J, Symmons D, Barton A
Rheumatology (Oxford). 2010
PubMed ID: 20219786
Dendritic cell targeted HIV gag protein vaccine provides help to a DNA vaccine including mobilization of protective CD8+ T cells.
Nchinda G, Amadu D, Trumpfheller C, Mizenina O, Uberla K, Steinman RM
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20160099
A novel allergen-specific therapy for allergy using CD40-silenced dendritic cells.
Suzuki M, Zheng X, Zhang X, Zhang ZX, Ichim TE, Sun H, Nakamura Y, Inagaki A, Beduhn M, Shunnar A, Garcia B, Min WP
J Allergy Clin Immunol. 2010
PubMed ID: 20226305
A common polymorphism in CD40 Kozak sequence (-1C/T) is associated with acute coronary syndrome.
Tian C, Qin W, Li L, Zheng W, Qiu F
Biomed Pharmacother. 2010
PubMed ID: 20137882
Pollen-induced oxidative stress influences both innate and adaptive immune responses via altering dendritic cell functions.
Csillag A, Boldogh I, Pazmandi K, Magyarics Z, Gogolak P, Sur S, Rajnavolgyi E, Bacsi A
J Immunol. 2010
PubMed ID: 20118277
CD70 expression by dendritic cells plays a critical role in the immunogenicity of CD40-independent, CD4+ T cell-dependent, licensed CD8+ T cell responses.
Van Deusen KE, Rajapakse R, Bullock TN
J Leukoc Biol. 2010
PubMed ID: 19952354
The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis.
Lee VW, Qin X, Wang Y, Zheng G, Wang Y, Wang Y, Ince J, Tan TK, Kairaitis LK, Alexander SI, Harris DC
Nephrol Dial Transplant. 2010
PubMed ID: 19889873
Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile.
Lutgens E, Lievens D, Beckers L, Wijnands E, Soehnlein O, Zernecke A, Seijkens T, Engel D, Cleutjens J, Keller AM, Naik SH, Boon L, Oufella HA, Mallat Z, Ahonen CL, Noelle RJ, de Winther MP, Daemen MJ, Biessen EA, Weber C
J Exp Med. 2010
PubMed ID: 20100871
Soluble CD40 ligand impairs the function of peripheral blood angiogenic outgrowth cells and increases neointimal formation after arterial injury.
Hristov M, Gümbel D, Lutgens E, Zernecke A, Weber C
Circulation. 2010
PubMed ID: 20048211
Tumor Necrosis Factor alpha (TNFalpha) regulates CD40 expression through SMAR1 phosphorylation.
Singh K, Sinha S, Malonia SK, Chattopadhyay S
Biochem Biophys Res Commun. 2010
PubMed ID: 20006573
The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels.
Portillo JA, Okenka G, Reed E, Subauste A, Van Grol J, Gentil K, Komatsu M, Tanaka K, Landreth G, Levine B, Subauste CS
PLoS One. 2010
PubMed ID: 21217818
Primary and malignant cholangiocytes undergo CD40 mediated Fas dependent apoptosis, but are insensitive to direct activation with exogenous Fas ligand.
Humphreys EH, Williams KT, Adams DH, Afford SC
PLoS One. 2010
PubMed ID: 21103345
Semi mature blood dendritic cells exist in patients with ductal pancreatic adenocarcinoma owing to inflammatory factors released from the tumor.
Tjomsland V, Spångeus A, Sandström P, Borch K, Messmer D, Larsson M
PLoS One. 2010
PubMed ID: 20976171
CD40: novel association with Crohn's disease and replication in multiple sclerosis susceptibility.
Blanco-Kelly F, Matesanz F, Alcina A, Teruel M, Díaz-Gallo LM, Gómez-García M, López-Nevot MA, Rodrigo L, Nieto A, Cardeña C, Alcain G, Díaz-Rubio M, de la Concha EG, Fernandez O, Arroyo R, Martín J, Urcelay E
PLoS One. 2010
PubMed ID: 20634952
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex.
Hostager BS, Fox DK, Whitten D, Wilkerson CG, Eipper BA, Francone VP, Rothman PB, Colgan JD
PLoS One. 2010
PubMed ID: 20614026
Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients.
Lehmann C, Lafferty M, Garzino-Demo A, Jung N, Hartmann P, Fätkenheuer G, Wolf JS, van Lunzen J, Romerio F
PLoS One. 2010
PubMed ID: 20559432
Pathogen-mediated inflammatory atherosclerosis is mediated in part via Toll-like receptor 2-induced inflammatory responses.
Hayashi C, Madrigal AG, Liu X, Ukai T, Goswami S, Gudino CV, Gibson FC, Genco CA
J Innate Immun. 2010
PubMed ID: 20505314
Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
Ban HJ, Heo JY, Oh KS, Park KJ
BMC Genet. 2010
PubMed ID: 20416077
Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients.
Jensen CJ, Stankovich J, Van der Walt A, Bahlo M, Taylor BV, van der Mei IA, Foote SJ, Kilpatrick TJ, Johnson LJ, Wilkins E, Field J, Danoy P, Brown MA, Australian and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), Rubio JP, Butzkueven H
PLoS One. 2010
PubMed ID: 20368992
RNAi-mediated CD40-CD154 interruption promotes tolerance in autoimmune arthritis.
Zheng X, Suzuki M, Zhang X, Ichim TE, Zhu F, Ling H, Shunnar A, Wang MH, Garcia B, Inman RD, Min WP
Arthritis Res Ther. 2010
PubMed ID: 20102615
CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD4(+) regulatory T cells.
Zheng J, Liu Y, Lau YL, Tu W
Cell Mol Immunol. 2010
PubMed ID: 20081875
Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer.
Pan PY, Ma G, Weber KJ, Ozao-Choy J, Wang G, Yin B, Divino CM, Chen SH
Cancer Res. 2010
PubMed ID: 19996287
CD40 signalling induces IL-10-producing, tolerogenic dendritic cells.
Tuettenberg A, Fondel S, Steinbrink K, Enk AH, Jonuleit H
Exp Dermatol. 2010
PubMed ID: 19889024
Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF
Circulation. 2009
PubMed ID: 19948975
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q
Occup Environ Med. 2009
PubMed ID: 19773279
Critical role of microglial CD40 in the maintenance of mechanical hypersensitivity in a murine model of neuropathic pain.
Cao L, Palmer CD, Malon JT, De Leo JA
Eur J Immunol. 2009
PubMed ID: 19750482
Identification, characterisation and regulation by CD40 activation of novel CD95 splice variants in CD95-apoptosis-resistant, human, B-cell non-Hodgkin's lymphoma.
Lajmanovich A, Ribeyron JB, Florin A, Fournier A, Pasquier MA, Duley S, Chauvet M, Plumas J, Bonnefoix T, Gressin R, Leroux D, Callanan MB
Exp Cell Res. 2009
PubMed ID: 19751723
Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells.
Carreño LJ, Pacheco R, Gutierrez MA, Jacobelli S, Kalergis AM
Immunology. 2009
PubMed ID: 20067533
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury.
Shen X, Wang Y, Gao F, Ren F, Busuttil RW, Kupiec-Weglinski JW, Zhai Y
Hepatology. 2009
PubMed ID: 19670423
TRAF5 is a critical mediator of in vitro signals and in vivo functions of LMP1, the viral oncogenic mimic of CD40.
Kraus ZJ, Nakano H, Bishop GA
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19805155
Regulatory T cells modulate postischemic neovascularization.
Zouggari Y, Ait-Oufella H, Waeckel L, Vilar J, Loinard C, Cochain C, Récalde A, Duriez M, Levy BI, Lutgens E, Lutgens E, Mallat Z, Silvestre JS
Circulation. 2009
PubMed ID: 19770391
Association of CD40 -1C/T polymorphism in the 5'-untranslated region and chronic obstructive pulmonary disease.
Liu Y, Liang WB, Gao LB, Wang YY, Zhang L
Clin Chim Acta. 2009
PubMed ID: 19622350
The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms.
Binstadt BA, Hebert JL, Ortiz-Lopez A, Bronson R, Benoist C, Mathis D
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19805369
Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses.
Bessa J, Jegerlehner A, Hinton HJ, Pumpens P, Saudan P, Schneider P, Bachmann MF
J Immunol. 2009
PubMed ID: 19710454
Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions.
Kim SH, Lee JE, Kim SH, Jee YK, Kim YK, Park HS, Min KU, Park HW, The Adverse Drug Reaction Research Group in Korea
Clin Exp Allergy. 2009
PubMed ID: 19735272
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
[Expression of CD40 in human gastric cancer tissue and its prognostic correlation]
Li R, Chen WC, Pang XQ, Zhang XG
Zhonghua Yi Xue Za Zhi. 2009
PubMed ID: 20058617
Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis.
van der Linden MP, Feitsma AL, le Cessie S, Kern M, Olsson LM, Raychaudhuri S, Begovich AB, Chang M, Catanese JJ, Kurreeman FA, van Nies J, van der Heijde DM, Gregersen PK, Huizinga TW, Toes RE, van der Helm-Van Mil AH
Arthritis Rheum. 2009
PubMed ID: 19644859
Fas apoptosis inhibitory molecule enhances CD40 signaling in B cells and augments the plasma cell compartment.
Kaku H, Rothstein TL
J Immunol. 2009
PubMed ID: 19592656
Common genetic variants in candidate genes and risk of familial lymphoid malignancies.
Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR
Br J Haematol. 2009
PubMed ID: 19573080
Involvement of CD40 targeting miR-224 and miR-486 on the progression of pancreatic ductal adenocarcinomas.
Mees ST, Mardin WA, Sielker S, Willscher E, Senninger N, Schleicher C, Colombo-Benkmann M, Haier J
Ann Surg Oncol. 2009
PubMed ID: 19475450
CD40/CD40L interaction induces Abeta production and increases gamma-secretase activity independently of tumor necrosis factor receptor associated factor (TRAF) signaling.
Volmar CH, Ait-Ghezala G, Frieling J, Weeks OI, Mullan MJ
Exp Cell Res. 2009
PubMed ID: 19422822
Angiotensin II upregulates Toll-like receptor 4 and enhances lipopolysaccharide-induced CD40 expression in rat peritoneal mesothelial cells.
Wu J, Yang X, Zhang YF, Zhou SF, Zhang R, Dong XQ, Fan JJ, Liu M, Yu XQ
Inflamm Res. 2009
PubMed ID: 19271152
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.
Guarda G, Dostert C, Staehli F, Cabalzar K, Castillo R, Tardivel A, Schneider P, Tschopp J
Nature. 2009
PubMed ID: 19494813
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene)
Nat Genet. 2009
PubMed ID: 19525955
Distinct roles of CD28- and CD40 ligand-mediated costimulation in the development of protective immunity and pathology during Chlamydia muridarum urogenital infection in mice.
Chen L, Cheng W, Shivshankar P, Lei L, Zhang X, Wu Y, Yeh IT, Zhong G
Infect Immun. 2009
PubMed ID: 19398542
CD40 and OX40 ligand are differentially regulated on asthmatic airway smooth muscle.
Krimmer DI, Loseli M, Hughes JM, Oliver BG, Moir LM, Hunt NH, Black JL, Burgess JK
Allergy. 2009
PubMed ID: 19220210
Interferon-beta therapy up-regulates BDNF secretion from PBMCs of MS patients through a CD40-dependent mechanism.
Azoulay D, Mausner-Fainberg K, Urshansky N, Fahoum F, Karni A
J Neuroimmunol. 2009
PubMed ID: 19419774
Up-regulation of the expression of costimulatory molecule CD40 in hepatocytes by hepatitis B virus X antigen.
Tang Y, Chen Y, Ni B, Yang D, Guo S, Wu Y
Biochem Biophys Res Commun. 2009
PubMed ID: 19336218
CD154-CD40 interactions are essential for thymus-dependent antibody production in zebrafish: insights into the origin of costimulatory pathway in helper T cell-regulated adaptive immunity in early vertebrates.
Gong YF, Xiang LX, Shao JZ
J Immunol. 2009
PubMed ID: 19494299
The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals.
Yanaba K, Bouaziz JD, Matsushita T, Tsubata T, Tedder TF
J Immunol. 2009
PubMed ID: 19494269
A novel mutation in CD40 and its functional characterization.
Qi CJ, Zheng L, Ma HB, Fei M, Qian KQ, Shen BR, Wu CP, Vihinen M, Zhang XG
Hum Mutat. 2009
PubMed ID: 19479954
CD40-independent engagement of mammalian hsp70 by antigen-presenting cells.
Binder RJ
J Immunol. 2009
PubMed ID: 19454680
Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia.
Wu QL, Buhtoiarov IN, Sondel PM, Rakhmilevich AL, Ranheim EA
J Immunol. 2009
PubMed ID: 19454672
Upregulation of the CD40-CD40 ligand system in pre-eclampsia.
Lukanov TH, Bojinova SI, Emin AL, Veleva GL, Popova VS, Konova EI
Int J Gynaecol Obstet. 2009
PubMed ID: 19272596
The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes.
Poggi M, Jager J, Paulmyer-Lacroix O, Peiretti F, Gremeaux T, Verdier M, Grino M, Stepanian A, Msika S, Burcelin R, de Prost D, Tanti JF, Alessi MC
Diabetologia. 2009
PubMed ID: 19183933
Individual and epistatic effects of genetic polymorphisms of B-cell co-stimulatory molecules on susceptibility to pemphigus foliaceus.
Malheiros D, Petzl-Erler ML
Genes Immun. 2009
PubMed ID: 19421221
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer.
Zhang M, Yao Z, Dubois S, Ju W, Müller JR, Waldmann TA
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19383782
[Expression of CD40 and CD40 ligand in peripheral blood mononuclear cells in children with bronchiolitis]
Zhu P, Zou LP
Zhongguo Dang Dai Er Ke Za Zhi. 2009
PubMed ID: 19470255
CD40 and B-cell receptor signalling induce MAPK family members that can either induce or repress Bcl-6 expression.
Batlle A, Papadopoulou V, Gomes AR, Willimott S, Melo JV, Naresh K, Lam EW, Wagner SD
Mol Immunol. 2009
PubMed ID: 19268365
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
Up-regulation of surfactant protein production in a mouse model of secondary pulmonary alveolar proteinosis.
Shibasaki M, Hashimoto K, Okamoto M, Hayashi Y, Imaizumi K, Hashimoto N, Ozaki N, Yokoi T, Takagi K, Hasegawa Y, Shimokata K, Kawabe T
Am J Respir Cell Mol Biol. 2009
PubMed ID: 18931325
Impaired maintenance of naturally acquired T-cell memory to the meningococcus in patients with B-cell immunodeficiency.
Morales-Aza B, Glennie SJ, Garcez TP, Davenport V, Johnston SL, Williams NA, Heyderman RS
Blood. 2009
PubMed ID: 19202131
Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60.
Ryu SJ, Jung KM, Yoo HS, Kim TW, Kim S, Chang J, Choi EY
Blood. 2009
PubMed ID: 19139082
Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting.
Longo NS, Lugar PL, Yavuz S, Zhang W, Krijger PH, Russ DE, Jima DD, Dave SS, Grammer AC, Lipsky PE
Blood. 2009
PubMed ID: 19023113
C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells.
Baruah P, Dumitriu IE, Malik TH, Cook HT, Dyson J, Scott D, Simpson E, Botto M
Blood. 2009
PubMed ID: 19171874
Recall responses by helpless memory CD8+ T cells are restricted by the up-regulation of PD-1.
Fuse S, Tsai CY, Molloy MJ, Allie SR, Zhang W, Yagita H, Usherwood EJ
J Immunol. 2009
PubMed ID: 19299723
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
Pediatr Infect Dis J. 2009
PubMed ID: 19258923
TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40.
Jabara HH, Weng Y, Sannikova T, Geha RS
Int Immunol. 2009
PubMed ID: 19228877
Marked induction of inducible nitric oxide synthase and tumor necrosis factor-alpha in rat CD40+ microglia by comparison to CD40- microglia.
Kawahara K, Yoshida A, Koga K, Yokoo S, Kuniyasu A, Gotoh T, Sawada M, Nakayama H
J Neuroimmunol. 2009
PubMed ID: 19211155
A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulation.
Zheng X, Vladau C, Zhang X, Suzuki M, Ichim TE, Zhang ZX, Li M, Carrier E, Garcia B, Jevnikar AM, Min WP
Blood. 2009
PubMed ID: 19164600
CD40 signaling activated by Epstein-Barr virus promotes cell survival and proliferation in gastric carcinoma-derived human epithelial cells.
Imadome K, Shimizu N, Yajima M, Watanabe K, Nakamura H, Takeuchi H, Fujiwara S
Microbes Infect. 2009
PubMed ID: 19397878
A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo.
Perona-Wright G, Jenkins SJ, O'Connor RA, Zienkiewicz D, McSorley HJ, Maizels RM, Anderton SM, MacDonald AS
J Immunol. 2009
PubMed ID: 19234175
Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function.
Rub A, Dey R, Jadhav M, Kamat R, Chakkaramakkil S, Majumdar S, Mukhopadhyaya R, Saha B
Nat Immunol. 2009
PubMed ID: 19198591
Inhibition of allergic responses by CD40 gene silencing.
Suzuki M, Zheng X, Zhang X, Ichim TE, Sun H, Kubo N, Beduhn M, Shunnar A, Garcia B, Min WP
Allergy. 2009
PubMed ID: 19175598
CD40/CD40L contributes to hypercholesterolemia-induced microvascular inflammation.
Stokes KY, Calahan L, Hamric CM, Russell JM, Granger DN
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19112095
Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 molecules.
Buhtoiarov IN, Rakhmilevich AL, Lanier LL, Ranheim EA, Sondel PM
J Immunol. 2009
PubMed ID: 19201847
WITHDRAWN: Association analysis of CD40 gene polymorphism with acute coronary syndrome.
Yan J, Wang C, Du R, Liu P, Chen G
Biomed Pharmacother. 2009
PubMed ID: 19246174
Mechanisms of LPS-induced CD40 expression in human peripheral blood monocytic cells.
Wu W, Alexis NE, Bromberg PA, Jaspers I, Peden DB
Biochem Biophys Res Commun. 2009
PubMed ID: 19118532
Genetic risk factors for rheumatoid arthritis differ in caucasian and Korean populations.
Lee HS, Korman BD, Le JM, Kastner DL, Remmers EF, Gregersen PK, Bae SC
Arthritis Rheum. 2009
PubMed ID: 19180477
CD40 regulates human dendritic cell-derived IL-7 production that, in turn, contributes to CD8(+) T-cell antigen-specific expansion.
Carreno BM, Becker-Hapak M, Linette GP
Immunol Cell Biol. 2009
PubMed ID: 19002156
Elevated plasma levels of soluble CD40 in incipient Alzheimer's disease.
Buchhave P, Janciauskiene S, Zetterberg H, Blennow K, Minthon L, Hansson O
Neurosci Lett. 2009
PubMed ID: 18996438
CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells.
Iezzi G, Sonderegger I, Ampenberger F, Schmitz N, Marsland BJ, Kopf M
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19136631
NKT-cell help to B lymphocytes can occur independently of cognate interaction.
Tonti E, Galli G, Malzone C, Abrignani S, Casorati G, Dellabona P
Blood. 2009
PubMed ID: 18832653
Impact of CD40 expression by flowcytometry on outcome of patients with non-Hodgkin's lymphoma.
Soliman MA, Fathy AA, Alkilani A, Abd El-Bary N, El-Bassal F
Egypt J Immunol. 2009
PubMed ID: 20726323
Impaired immune responses in the lungs of aged mice following influenza infection.
Toapanta FR, Ross TM
Respir Res. 2009
PubMed ID: 19922665
Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation.
Carpenter EL, Mick R, Rüter J, Vonderheide RH
J Transl Med. 2009
PubMed ID: 19906293
Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
Smith AJ, Karpova Y, D'Agostino R, Willingham M, Kulik G
PLoS One. 2009
PubMed ID: 19593445
Immune modulation through RNA interference-mediated silencing of CD40 in dendritic cells.
Karimi MH, Ebadi P, Pourfathollah AA, Soheili ZS, Samiee S, Ataee Z, Tabei SZ, Moazzeni SM
Cell Immunol. 2009
PubMed ID: 19589505
Inhibition of lung cancer cell proliferation by CD40 signaling through tumor necrosis factor I.
Lu XD, Zhu XL, Chen C, Zhang GB, Zhang XG, Huang JA
Chin J Cancer. 2009
PubMed ID: 19448410
TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses.
Kobayashi T, Kim TS, Jacob A, Walsh MC, Kadono Y, Fuentes-Pananá E, Yoshioka T, Yoshimura A, Yamamoto M, Kaisho T, Akira S, Monroe JG, Choi Y
PLoS One. 2009
PubMed ID: 19270748
Cationic liposome-mediated transfection of CD40 ligand gene inhibits hepatic tumor growth of hepatocellular carcinoma in mice.
Jiang YF, Ma J, He Y, Zhang YH, Xu Y, Gong GZ
J Zhejiang Univ Sci B. 2009
PubMed ID: 19198017
STAT2*C related genotypes and allele but not TLR4 and CD40 gene polymorphisms are associated with higher susceptibility for asthma.
Hsieh YY, Wan L, Chang CC, Tsai CH, Tsai FJ
Int J Biol Sci. 2009
PubMed ID: 19159017
The phagosomal proteome in interferon-gamma-activated macrophages.
Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P
Immunity. 2009
PubMed ID: 19144319
OX40 costimulation prevents allograft acceptance induced by CD40-CD40L blockade.
Burrell BE, Lu G, Li XC, Bishop DK
J Immunol. 2009
PubMed ID: 19109169
Dendritic cell activation by combined exposure to anti-CD40 plus interleukin (IL)-12 and IL-18 efficiently stimulates anti-tumor immunity.
Balkow S, Loser K, Krummen M, Higuchi T, Rothoeft T, Apelt J, Tuettenberg A, Weishaupt C, Beissert S, Grabbe S
Exp Dermatol. 2009
PubMed ID: 19054060
Anthocyanin attenuates CD40-mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation.
Xia M, Ling W, Zhu H, Ma J, Wang Q, Hou M, Tang Z, Guo H, Liu C, Ye Q
Atherosclerosis. 2009
PubMed ID: 18495129
Neutralizing interleukin-4 prevents transplant arteriosclerosis mediated by indirect pathway T cells under CD40-CD154 costimulation blockade.
Spriewald BM, Ensminger SM, Bushell A, Wood KJ
Transplantation. 2008
PubMed ID: 19077898
CD40 mediates retinal inflammation and neurovascular degeneration.
Portillo JA, Van Grol J, Zheng L, Okenka G, Gentil K, Garland A, Carlson EC, Kern TS, Subauste CS
J Immunol. 2008
PubMed ID: 19050292
c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches.
Hallaert DY, Jaspers A, van Noesel CJ, van Oers MH, Kater AP, Eldering E
Blood. 2008
PubMed ID: 18796631
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
De Santo C, Salio M, Masri SH, Lee LY, Dong T, Speak AO, Porubsky S, Booth S, Veerapen N, Besra GS, Gröne HJ, Platt FM, Zambon M, Cerundolo V
J Clin Invest. 2008
PubMed ID: 19033672
CD40-induced signaling in human endothelial cells results in mTORC2- and Akt-dependent expression of vascular endothelial growth factor in vitro and in vivo.
Dormond O, Contreras AG, Meijer E, Datta D, Flynn E, Pal S, Briscoe DM
J Immunol. 2008
PubMed ID: 19018001
Uncoupling of induced protein processing from maturation in dendritic cells exposed to a highly antigenic preparation from a helminth parasite.
Marshall FA, Pearce EJ
J Immunol. 2008
PubMed ID: 19017945
Characterization of natural human antagonistic soluble CD40 isoforms produced through alternative splicing.
Eshel D, Toporik A, Efrati T, Nakav S, Chen A, Douvdevani A
Mol Immunol. 2008
PubMed ID: 18849075
Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer's disease.
Ait-ghezala G, Abdullah L, Volmar CH, Paris D, Luis CA, Quadros A, Mouzon B, Mullan MA, Keegan AP, Parrish J, Crawford FC, Mathura VS, Mullan MJ
Cytokine. 2008
PubMed ID: 18835787
CD40 engagement on dendritic cells, but not on B or T cells, is required for long-term control of murine gammaherpesvirus 68.
Giannoni F, Shea A, Inglis C, Lee LN, Sarawar SR
J Virol. 2008
PubMed ID: 18768977
CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling.
Pluvinet R, Olivar R, Krupinski J, Herrero-Fresneda I, Luque A, Torras J, Cruzado JM, Grinyó JM, Sumoy L, Aran JM
Blood. 2008
PubMed ID: 18669876
CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming.
Martín-Fontecha A, Baumjohann D, Guarda G, Reboldi A, Hons M, Lanzavecchia A, Sallusto F
J Exp Med. 2008
PubMed ID: 18838544
Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects.
Derradji H, Bekaert S, De Meyer T, Jacquet P, Abou-El-Ardat K, Ghardi M, Arlette M, Baatout S
Dev Biol. 2008
PubMed ID: 18722365
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FA, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil AH, Neale BM, Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TW, Shadick NA, Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes RE, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ, Plenge RM
Nat Genet. 2008
PubMed ID: 18794853
CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1.
Moschonas A, Kouraki M, Knox PG, Thymiakou E, Kardassis D, Eliopoulos AG
Mol Cell Biol. 2008
PubMed ID: 18694960
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice.
Laporte V, Ait-Ghezala G, Volmar CH, Ganey C, Ganey N, Wood M, Mullan M
Brain Res. 2008
PubMed ID: 18606155
Potent tumor-specific protection ignited by adoptively transferred CD4+ T cells.
Liu Z, Noh HS, Chen J, Kim JH, Falo LD, You Z
J Immunol. 2008
PubMed ID: 18768895
A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virus.
Carragher DM, Kaminski DA, Moquin A, Hartson L, Randall TD
J Immunol. 2008
PubMed ID: 18768874
[A study of costimulatory molecules in allergic allergic rhinitis patients].
Zhu R, Liu G, Li W, Wang Z, Chen H, Zhang W
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008
PubMed ID: 19086656
Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.
Irla M, Hugues S, Gill J, Nitta T, Hikosaka Y, Williams IR, Hubert FX, Scott HS, Takahama Y, Holländer GA, Reith W
Immunity. 2008
PubMed ID: 18799151
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.
Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y
Immunity. 2008
PubMed ID: 18799150
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta T, Takahama Y, Inoue J
Immunity. 2008
PubMed ID: 18799149
OK432-activated human dendritic cells kill tumor cells via CD40/CD40 ligand interactions.
Hill KS, Errington F, Steele LP, Merrick A, Morgan R, Selby PJ, Georgopoulos NT, O'Donnell DM, Melcher AA
J Immunol. 2008
PubMed ID: 18713981
CD40 expression on antigen presenting cells and correlation with disease severity in atopic dermatitis.
Oflazoglu E, Simpson EL, Takiguchi R, Hanifin JM, Grewal IS, Gerber HP
Eur J Dermatol. 2008
PubMed ID: 18693155
Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation.
McPherson M, Wei B, Turovskaya O, Fujiwara D, Brewer S, Braun J
Am J Physiol Gastrointest Liver Physiol. 2008
PubMed ID: 18617557
A novel polymorphism of the human CD40 receptor with enhanced function.
Peters AL, Plenge RM, Graham RR, Altshuler DM, Moser KL, Gaffney PM, Bishop GA
Blood. 2008
PubMed ID: 18591382
Association of CD40 Gene and Thyroglobulin Gene with later-onset Graves disease in Taiwanese.
Hsiao JY, Hsieh MC, Hsiao CT, Weng HH, Ke DS
Eur J Endocrinol. 2008
PubMed ID: 18755875
High expression of CD40 on B-cell precursor acute lymphoblastic leukemia blasts is an independent risk factor associated with improved survival and enhanced capacity to up-regulate the death receptor CD95.
Troeger A, Glouchkova L, Ackermann B, Escherich G, Meisel R, Hanenberg H, den Boer ML, Pieters R, Janka-Schaub GE, Goebel U, Laws HJ, Dilloo D
Blood. 2008
PubMed ID: 18552209
Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy.
Lineberry NB, Su LL, Lin JT, Coffey GP, Seroogy CM, Fathman CG
J Immunol. 2008
PubMed ID: 18641297
Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.
Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M
Science. 2008
PubMed ID: 18635759
Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjögren's syndrome.
Qian Y, Giltiay N, Xiao J, Wang Y, Tian J, Han S, Scott M, Carter R, Jorgensen TN, Li X
Eur J Immunol. 2008
PubMed ID: 18624351
CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 production.
Wong KL, Lew FC, MacAry PA, Kemeny DM
Eur J Immunol. 2008
PubMed ID: 18600823
Up-regulation of CD40 with juxtacrine activity in human nonsmall lung cancer cells correlates with poor prognosis.
Ishikawa K, Miyamoto M, Yoshioka T, Kato T, Kaji M, Ohbuchi T, Hirano S, Itoh T, Dosaka-Akita H, Kondo S
Cancer. 2008
PubMed ID: 18548529
Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells.
Polo JM, Ci W, Licht JD, Melnick A
Blood. 2008
PubMed ID: 18487509
Interleukin-12 is necessary for the priming of CD4+ T cells required during the elicitation of HIV-1 gp120-specific cytotoxic T-lymphocyte function.
Gupta S, Boppana R, Mishra GC, Saha B, Mitra D
Immunology. 2008
PubMed ID: 18298551
A C >T polymorphism located at position -1 of the Kozak sequence of CD40 gene is associated with low bone mass in Spanish postmenopausal women.
Pineda B, Laporta P, Hermenegildo C, Cano A, García-Pérez MA
Osteoporos Int. 2008
PubMed ID: 18097708
CD40 ligand protects from TRAIL-induced apoptosis in follicular lymphomas through NF-kappaB activation and up-regulation of c-FLIP and Bcl-xL.
Travert M, Ame-Thomas P, Pangault C, Morizot A, Micheau O, Semana G, Lamy T, Fest T, Tarte K, Guillaudeux T
J Immunol. 2008
PubMed ID: 18606651
CD4 help regulates expression of crucial genes involved in CD8 T cell memory and sensitivity to regulatory elements.
Rapetti L, Meunier S, Pontoux C, Tanchot C
J Immunol. 2008
PubMed ID: 18566395
CTL-promoting effects of CD40 stimulation outweigh B cell-stimulatory effects resulting in B cell elimination and disease improvement in a murine model of lupus.
Puliaev R, Puliaeva I, Welniak LA, Ryan AE, Haas M, Murphy WJ, Via CS
J Immunol. 2008
PubMed ID: 18566369
Novel vaccination for allergy through gene silencing of CD40 using small interfering RNA.
Suzuki M, Zheng X, Zhang X, Li M, Vladau C, Ichim TE, Sun H, Min LR, Garcia B, Min WP
J Immunol. 2008
PubMed ID: 18523314
Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor.
Saunderson SC, Schuberth PC, Dunn AC, Miller L, Hock BD, MacKay PA, Koch N, Jack RW, McLellan AD
J Immunol. 2008
PubMed ID: 18523279
Full development of Th2 immunity requires both innate and adaptive sources of CD154.
Jenkins SJ, Perona-Wright G, MacDonald AS
J Immunol. 2008
PubMed ID: 18523272
Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis.
Hömig-Hölzel C, Hojer C, Rastelli J, Casola S, Strobl LJ, Müller W, Quintanilla-Martinez L, Gewies A, Ruland J, Rajewsky K, Zimber-Strobl U
J Exp Med. 2008
PubMed ID: 18490492
CD4+T cells in CIKs (CD4+ CIKs) reversed resistance to fas-mediated apoptosis through CD40/CD40L ligation rather than IFN-gamma stimulation.
Yu J, Zhang W, Jiang H, Li H, Cao S, Ren X
Cancer Biother Radiopharm. 2008
PubMed ID: 18593367
Modulation of neuronal differentiation by CD40 isoforms.
Hou H, Obregon D, Lou D, Ehrhart J, Fernandez F, Silver A, Tan J
Biochem Biophys Res Commun. 2008
PubMed ID: 18312851
Expression of CD40 in ovarian cancer and adenovirus-mediated CD40 ligand therapy on ovarian cancer in vitro.
Jiang E, He X, Chen X, Sun G, Wu H, Wei Y, Zhao X
Tumori. 2008
PubMed ID: 18705404
Expression of CD40 and growth-inhibitory activity of CD40 ligand in colon cancer ex vivo.
Wu Y, Wang L, He X, Xu H, Zhou L, Zhao F, Zhang Y
Cell Immunol. 2008
PubMed ID: 18603231
The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling.
Donners MM, Beckers L, Lievens D, Munnix I, Heemskerk J, Janssen BJ, Wijnands E, Cleutjens J, Zernecke A, Weber C, Ahonen CL, Benbow U, Newby AC, Noelle RJ, Daemen MJ, Lutgens E
Blood. 2008
PubMed ID: 18195092
A C/T Polymorphism in CD40 Gene is Not Associated with Susceptibility and Phenotype of Graves' Disease in Taiwanese.
Hsiao JY, Tien KJ, Hsiao CT, Hsieh MC
Endocr J. 2008
PubMed ID: 18446002
A functional TNFRSF5 gene variant is associated with risk of lymphoma.
Skibola CF, Nieters A, Bracci PM, Curry JD, Agana L, Skibola DR, Hubbard A, Becker N, Smith MT, Holly EA
Blood. 2008
PubMed ID: 18287517
Distinct effect of CD40 and TNF-signaling on the chemokine/chemokine receptor expression and function of the human monocyte-derived dendritic cells.
Xia Y, Dai J, Lu P, Huang Y, Zhu Y, Zhang X
Cell Mol Immunol. 2008
PubMed ID: 18445342
Invariant NKT cells promote CD8+ cytotoxic T cell responses by inducing CD70 expression on dendritic cells.
Taraban VY, Martin S, Attfield KE, Glennie MJ, Elliott T, Elewaut D, Van Calenbergh S, Linclau B, Al-Shamkhani A
J Immunol. 2008
PubMed ID: 18354184
CD40 on APCs is needed for optimal programming, maintenance, and recall of CD8+ T cell memory even in the absence of CD4+ T cell help.
Hernandez MG, Shen L, Rock KL
J Immunol. 2008
PubMed ID: 18354158
Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input.
White AJ, Withers DR, Parnell SM, Scott HS, Finke D, Lane PJ, Jenkinson EJ, Anderson G
Eur J Immunol. 2008
PubMed ID: 18350550
Simvastatin reduces platelet-endocardium adhesion in atrial fibrillation.
Chello M, Spadaccio C, Patti G, Lusini M, Barbato R, Goffredo C, Di Sciascio G, Covino E
Atherosclerosis. 2008
PubMed ID: 17904146
Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway.
Nakamura K, Miyazato A, Xiao G, Hatta M, Inden K, Aoyagi T, Shiratori K, Takeda K, Akira S, Saijo S, Iwakura Y, Adachi Y, Ohno N, Suzuki K, Fujita J, Kaku M, Kawakami K
J Immunol. 2008
PubMed ID: 18322216
Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production.
Douin-Echinard V, Laffont S, Seillet C, Delpy L, Krust A, Chambon P, Gourdy P, Arnal JF, Guéry JC
J Immunol. 2008
PubMed ID: 18322171
Costimulatory blockade of CD154-CD40 in combination with T-cell lymphodepletion results in prevention of allogeneic sensitization.
Xu H, Yan J, Huang Y, Chilton PM, Ding C, Schanie CL, Wang L, Ildstad ST
Blood. 2008
PubMed ID: 17827394
[Association between inflammatory cytokine CD40 gene polymorphism and risk of acute coronary syndrome]
Tian CX, Li Y, Wang M, Xia ZE, Li XY, Huang CX
Zhonghua Xin Xue Guan Bing Za Zhi. 2008
PubMed ID: 19099972
Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells.
Strainic MG, Liu J, Huang D, An F, Lalli PN, Muqim N, Shapiro VS, Dubyak GR, Heeger PS, Medof ME
Immunity. 2008
PubMed ID: 18328742
CD40 ligation decreases its protein half-life at the cell surface.
Tucker TA, Schwiebert LM
Eur J Immunol. 2008
PubMed ID: 18253927
ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction.
Vu F, Dianzani U, Ware CF, Mak T, Gommerman JL
J Immunol. 2008
PubMed ID: 18250437
LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1.
Rastelli J, Hömig-Hölzel C, Seagal J, Müller W, Hermann AC, Rajewsky K, Zimber-Strobl U
Blood. 2008
PubMed ID: 18006702
Coculture of human liver macrophages and cholangiocytes leads to CD40-dependent apoptosis and cytokine secretion.
Alabraba EB, Lai V, Boon L, Wigmore SJ, Adams DH, Afford SC
Hepatology. 2008
PubMed ID: 17999420
CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis.
Nolan A, Weiden M, Kelly A, Hoshino Y, Hoshino S, Mehta N, Gold JA
Am J Respir Crit Care Med. 2008
PubMed ID: 17989345
Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression.
Rezai-Zadeh K, Ehrhart J, Bai Y, Sanberg PR, Bickford P, Tan J, Shytle RD
J Neuroinflammation. 2008
PubMed ID: 18817573
Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.
Skibola CF, Bracci PM, Halperin E, Nieters A, Hubbard A, Paynter RA, Skibola DR, Agana L, Becker N, Tressler P, Forrest MS, Sankararaman S, Conde L, Holly EA, Smith MT
PLoS ONE. 2008
PubMed ID: 18636124
Neutrophil CD40 enhances platelet-mediated inflammation.
Vanichakarn P, Blair P, Wu C, Freedman JE, Chakrabarti S
Thromb Res. 2008
PubMed ID: 18289643
Relationship between the serum sCD40L level and aspirin-resistant platelet aggregation in patients with stable coronary artery disease.
Pamukcu B, Oflaz H, Onur I, Midilli K, Yilmaz G, Yilmaz E, Nisanci Y
Circ J. 2008
PubMed ID: 18159101
TRAF2 and p38 are involved in B cells CD40-mediated APE/Ref-1 nuclear translocation: a novel pathway in B cell activation.
Merluzzi S, D'Orlando O, Leonardi A, Vitale G, Pucillo C
Mol Immunol. 2008
PubMed ID: 17599408
Expression of RANTES and MCP-1 in epithelial cells is regulated via LMP1 and CD40.
Buettner M, Meyer B, Schreck S, Niedobitek G
Int J Cancer. 2007
PubMed ID: 17721998
Effect of exogenous ghrelin on cell differentiation antigen 40 expression in endothelial cells.
Zhang M, Yuan F, Chen H, Qiu X, Fang W
Acta Biochim Biophys Sin (Shanghai). 2007
PubMed ID: 18064390
Association between circulating level of CD40 ligand and angiographic morphologic features indicating high-burden thrombus formation in patients with acute myocardial infarction undergoing primary coronary intervention.
Youssef AA, Chang LT, Sheu JJ, Lee FY, Chua S, Yeh KH, Yang CH, Wu CJ, Yip HK
Circ J. 2007
PubMed ID: 18037736
Susceptible alleles of the CD40 and CTLA-4 genes are not associated with the relapse after antithyroid withdrawal in Graves' disease.
Kim KW, Park YJ, Kim TY, Park do J, Park KS, Cho BY
Thyroid. 2007
PubMed ID: 17949264
Monocytes are activated in patients with myelodysplastic syndromes and can contribute to bone marrow failure through CD40-CD40L interactions with T helper cells.
Meers S, Kasran A, Boon L, Lemmens J, Ravoet C, Boogaerts M, Verhoef G, Verfaillie C, Delforge M
Leukemia. 2007
PubMed ID: 17805323
Cyclic stretch controls the expression of CD40 in endothelial cells by changing their transforming growth factor-beta1 response.
Korff T, Aufgebauer K, Hecker M
Circulation. 2007
PubMed ID: 17967972
Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro.
Dopheide JF, Sester U, Schlitt A, Horstick G, Rupprecht HJ, Münzel T, Blankenberg S
Coron Artery Dis. 2007
PubMed ID: 17925605
High expression of CD40 on skin fibroblasts from patients with systemic sclerosis.
Jun JB, Kim TH, Na YI, Yoo DH
Rheumatol Int. 2007
PubMed ID: 17687557
A novel mechanism for TNFR-associated factor 6-dependent CD40 signaling.
Rowland SL, Tremblay MM, Ellison JM, Stunz LL, Bishop GA, Hostager BS
J Immunol. 2007
PubMed ID: 17878362
Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B.
Qiao G, Lei M, Li Z, Sun Y, Minto A, Fu YX, Ying H, Quigg RJ, Zhang J
J Immunol. 2007
PubMed ID: 17878343
Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation.
Castigli E, Wilson SA, Elkhal A, Ozcan E, Garibyan L, Geha RS
J Allergy Clin Immunol. 2007
PubMed ID: 17689597
Rapid elimination of Toxoplasma gondii by gamma interferon-primed mouse macrophages is independent of CD40 signaling.
Zhao Y, Wilson D, Matthews S, Yap GS
Infect Immun. 2007
PubMed ID: 17682046
Nonspecific CD4(+) T cells with uptake of antigen-specific dendritic cell-released exosomes stimulate antigen-specific CD8(+) CTL responses and long-term T cell memory.
Hao S, Yuan J, Xiang J
J Leukoc Biol. 2007
PubMed ID: 17626150
Lipid rafts regulate cellular CD40 receptor localization in vascular endothelial cells.
Xia M, Wang Q, Zhu H, Ma J, Hou M, Tang Z, Li J, Ling W
Biochem Biophys Res Commun. 2007
PubMed ID: 17678876
Leptin induces CD40 expression through the activation of Akt in murine dendritic cells.
Lam QL, Zheng BJ, Jin DY, Cao X, Lu L
J Biol Chem. 2007
PubMed ID: 17660512
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B
J Infect Dis. 2007
PubMed ID: 17703412
CD40-mediated death and cytokine secretion in colorectal cancer: a potential target for inflammatory tumour cell killing.
Georgopoulos NT, Merrick A, Scott N, Selby PJ, Melcher A, Trejdosiewicz LK
Int J Cancer. 2007
PubMed ID: 17534894
[Effect of prolactin on CD40/CD154 expression on peripheral blood mononuclear cells in patients with systemic lupus erythematosus]
Wang N, Peng XB, Zeng K
Nan Fang Yi Ke Da Xue Xue Bao. 2007
PubMed ID: 17884785
Association and linkage studies of the 20q11.2 region (GRD-2 locus) with Graves' disease in the Tunisian population.
Makni K, Hadj Kacem H, Rebaï A, Abid M, Ayadi H
Ann Hum Biol. 2007
PubMed ID: 17786592
CD40-CD40 ligand interactions promote trafficking of CD8+ T cells into the brain and protection against West Nile virus encephalitis.
Sitati E, McCandless EE, Klein RS, Diamond MS
J Virol. 2007
PubMed ID: 17626103
Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase.
Shi M, Ye Z, Umeshappa KS, Moyana T, Xiang J
Biochem Biophys Res Commun. 2007
PubMed ID: 17618911
Levels of CD40 expression on dendritic cells dictate tumour growth or regression.
Murugaiyan G, Martin S, Saha B
Clin Exp Immunol. 2007
PubMed ID: 17488293
Up-regulation of c-FLIPS+R upon CD40 stimulation is associated with inhibition of CD95-induced apoptosis in primary precursor B-ALL.
Troeger A, Schmitz I, Siepermann M, Glouchkova L, Gerdemann U, Janka-Schaub GE, Schulze-Osthoff K, Dilloo D
Blood. 2007
PubMed ID: 17376892
The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation.
Lu LF, Ahonen CL, Lind EF, Raman VS, Cook WJ, Lin LL, Noelle RJ
Blood. 2007
PubMed ID: 17360936
CD40-40L signaling in vascular inflammation.
Chakrabarti S, Blair P, Freedman JE
J Biol Chem. 2007
PubMed ID: 17459878
CD40 ligand-mediated activation of the de novo RelB NF-kappaB synthesis pathway in transformed B cells promotes rescue from apoptosis.
Mineva ND, Rothstein TL, Meyers JA, Lerner A, Sonenshein GE
J Biol Chem. 2007
PubMed ID: 17446175
Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation.
French RR, Taraban VY, Crowther GR, Rowley TF, Gray JC, Johnson PW, Tutt AL, Al-Shamkhani A, Glennie MJ
Blood. 2007
PubMed ID: 17311995
Expression of lymphotoxin-alphabeta on antigen-specific T cells is required for DC function.
Summers-DeLuca LE, McCarthy DD, Cosovic B, Ward LA, Lo CC, Scheu S, Pfeffer K, Gommerman JL
J Exp Med. 2007
PubMed ID: 17452522
Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model.
Khiong K, Murakami M, Kitabayashi C, Ueda N, Sawa S, Sakamoto A, Kotzin BL, Rozzo SJ, Ishihara K, Verella-Garcia M, Kappler J, Marrack P, Hirano T
J Clin Invest. 2007
PubMed ID: 17476359
B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo.
Li Y, Toraldo G, Li A, Yang X, Zhang H, Qian WP, Weitzmann MN
Blood. 2007
PubMed ID: 17202317
Association analysis of CD40 polymorphisms with asthma and the level of serum total IgE.
Park JH, Chang HS, Park CS, Jang AS, Park BL, Rhim TY, Uh ST, Kim YH, Chung IY, Shin HD
Am J Respir Crit Care Med. 2007
PubMed ID: 17255560
A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression.
Jacobson EM, Huber AK, Akeno N, Sivak M, Li CW, Concepcion E, Ho K, Tomer Y
Genes Immun. 2007
PubMed ID: 17344890
CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1.
Zirlik A, Maier C, Gerdes N, MacFarlane L, Soosairajah J, Bavendiek U, Ahrens I, Ernst S, Bassler N, Missiou A, Patko Z, Aikawa M, Schönbeck U, Bode C, Libby P, Peter K
Circulation. 2007
PubMed ID: 17372166
Cooperativity in the interaction of synthetic CD40L mimetics with CD40 and its implication in cell signaling.
Wieckowski S, Trouche N, Chaloin O, Guichard G, Fournel S, Hoebeke J
Biochemistry. 2007
PubMed ID: 17319699
[Correlation of CD40 gene polymorphisms with acute coronary syndrome, hypertension and diabetes]
Li Y, Tian CX, Wang M, Xia ZE
Zhonghua Yi Xue Za Zhi. 2007
PubMed ID: 17553307
CD40-CD40 ligand mediates the recruitment of leukocytes and platelets in the inflamed murine colon.
Vowinkel T, Anthoni C, Wood KC, Stokes KY, Russell J, Gray L, Bharwani S, Senninger N, Alexander JS, Krieglstein CF, Grisham MB, Granger DN
Gastroenterology. 2007
PubMed ID: 17324402
CD40-CD40 ligand interaction between dendritic cells and CD8+ T cells is needed to stimulate maximal T cell responses in the absence of CD4+ T cell help.
Hernandez MG, Shen L, Rock KL
J Immunol. 2007
PubMed ID: 17312128
Relationship between upregulation of CD40 system and restenosis in patients after percutaneous coronary intervention.
Yan JC, Ding S, Liang Y, Ma GS, Zhu J, Feng Y, Luo D
Acta Pharmacol Sin. 2007
PubMed ID: 17302995
B cells play a cooperative role via CD40L-CD40 interaction in T cell-mediated experimental autoimmune neuritis in Lewis rats.
Zhu W, Mix E, Jin T, Adem A, Zhu J
Neurobiol Dis. 2007
PubMed ID: 17188497
Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.
Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC
Atherosclerosis. 2007
PubMed ID: 16806233
Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN.
Hervas-Stubbs S, Rueda P, Lopez L, Leclerc C
J Immunol. 2007
PubMed ID: 17277142
TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses.
Heer AK, Shamshiev A, Donda A, Uematsu S, Akira S, Kopf M, Marsland BJ
J Immunol. 2007
PubMed ID: 17277123
Stimulation of cell surface CCR5 and CD40 molecules by their ligands or by HSP70 up-regulates APOBEC3G expression in CD4(+) T cells and dendritic cells.
Pido-Lopez J, Whittall T, Wang Y, Bergmeier LA, Babaahmady K, Singh M, Lehner T
J Immunol. 2007
PubMed ID: 17237417
Role of CD40-dependent down-regulation of CD154 in impaired induction of CD154 in CD4(+) T cells from HIV-1-infected patients.
Subauste CS, Subauste A, Wessendarp M
J Immunol. 2007
PubMed ID: 17237414
Combined TLR/CD40 stimulation mediates potent cellular immunity by regulating dendritic cell expression of CD70 in vivo.
Sanchez PJ, McWilliams JA, Haluszczak C, Yagita H, Kedl RM
J Immunol. 2007
PubMed ID: 17237405
Proinflammatory cytokine synthesis by mucosal fibroblasts from mouse colitis is enhanced by interferon-gamma-mediated up-regulation of CD40 signalling.
De L Karlson T, Whiting CV, Bland PW
Clin Exp Immunol. 2007
PubMed ID: 17223973
The CD40-induced protection against CD95-mediated apoptosis is associated with a rapid upregulation of anti-apoptotic c-FLIP.
Eeva J, Ropponen A, Nuutinen U, Eeva ST, Mättö M, Eray M, Pelkonen J
Mol Immunol. 2007
PubMed ID: 16901543
Guanosine inhibits CD40 receptor expression and function induced by cytokines and beta amyloid in mouse microglia cells.
D'Alimonte I, Flati V, D'Auro M, Toniato E, Martinotti S, Rathbone MP, Jiang S, Ballerini P, Di Iorio P, Caciagli F, Ciccarelli R
J Immunol. 2007
PubMed ID: 17202332
A costimulatory function for T cell CD40.
Munroe ME, Bishop GA
J Immunol. 2007
PubMed ID: 17202327
Soluble CD40 and its ligand CD154 in patients with Graves' ophthalmopathy during combined therapy with corticosteroids and teleradiotherapy.
Myśliwiec J, Waligórski D, Nikołajuk A, Górska M
Adv Med Sci. 2007
PubMed ID: 18217399
Limited costimulatory molecule expression on renal tubular epithelial cells impairs T cell activation.
Waeckerle-Men Y, Starke A, Wahl PR, Wüthrich RP
Kidney Blood Press Res. 2007
PubMed ID: 17975322
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
C4b binding protein binds to CD154 preventing CD40 mediated cholangiocyte apoptosis: a novel link between complement and epithelial cell survival.
Williams KT, Young SP, Negus A, Young LS, Adams DH, Afford SC
PLoS One. 2007
PubMed ID: 17225862
sCD40 ligand determined in maternal and umbilical cord blood in pregnancies complicated by pre-eclampsia with and without intrauterine growth retardation.
Laskowska M, Laskowska K, Leszczyńska-Gorzelak B, Oleszczuk J
Gynecol Obstet Invest. 2007
PubMed ID: 17199090
The net effect of costimulatory blockers is dependent on the subset and activation status of the autoreactive T cells.
Zhang P, Sun D, Ke Y, Kaplan HJ, Shao H
J Immunol. 2007
PubMed ID: 17182586
Dynamics and magnitude of virus-induced polyclonal B cell activation mediated by BCR-independent presentation of viral antigen.
Jellison ER, Guay HM, Szomolanyi-Tsuda E, Welsh RM
Eur J Immunol. 2007
PubMed ID: 17163452
TACI attenuates antibody production costimulated by BAFF-R and CD40.
Sakurai D, Kanno Y, Hase H, Kojima H, Okumura K, Kobata T
Eur J Immunol. 2007
PubMed ID: 17154264
CD40-CD154 expression in calcified and non-calcified coronary lesions of patients with chronic renal failure.
Campean V, Neureiter D, Nonnast-Daniel B, Garlichs C, Gross ML, Amann K
Atherosclerosis. 2007
PubMed ID: 16494885
Gut IgA class switch recombination in the absence of CD40 does not occur in the lamina propria and is independent of germinal centers.
Bergqvist P, Gärdby E, Stensson A, Bemark M, Lycke NY
J Immunol. 2006
PubMed ID: 17114448
Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals.
Boonstra A, Rajsbaum R, Holman M, Marques R, Asselin-Paturel C, Pereira JP, Bates EE, Akira S, Vieira P, Liu YJ, Trinchieri G, O'Garra A
J Immunol. 2006
PubMed ID: 17114424
Neutralizing IL-7 promotes long-term allograft survival induced by CD40/CD40L costimulatory blockade.
Wang Y, Dai H, Liu Z, Cheng X, Tellides G, Dai Z
Am J Transplant. 2006
PubMed ID: 17062001
Fucoidan prevents C epsilon germline transcription and NFkappaB p52 translocation for IgE production in B cells.
Oomizu S, Yanase Y, Suzuki H, Kameyoshi Y, Hide M
Biochem Biophys Res Commun. 2006
PubMed ID: 17027924
Functional dichotomy in CD40 reciprocally regulates effector T cell functions.
Murugaiyan G, Agrawal R, Mishra GC, Mitra D, Saha B
J Immunol. 2006
PubMed ID: 17082576
[Serum levels and clinical significance of soluble CD40 in liver disease]
Liu H, Qi CJ, Zhuang YM, Gan JH, Li HL, Yin CS, Zhang XG
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2006
PubMed ID: 17077013
Giving blood: a new role for CD40 in tumorigenesis.
Bergmann S, Pandolfi PP
J Exp Med. 2006
PubMed ID: 17043147
Triggering CD40 on endothelial cells contributes to tumor growth.
Chiodoni C, Iezzi M, Guiducci C, Sangaletti S, Alessandrini I, Ratti C, Tiboni F, Musiani P, Granger DN, Colombo MP
J Exp Med. 2006
PubMed ID: 17043144
Induced expression of murine gamma2a by CD40 ligation independently of IFN-gamma.
Collins JT, Shi J, Burrell BE, Bishop DK, Dunnick WA
J Immunol. 2006
PubMed ID: 17015727
IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling.
Hellings PW, Kasran A, Bullens D, Overbergh L, Mathieu C, Heremans H, Matthys P, Boon L, Jorissen M, Ceuppens JL
J Immunol. 2006
PubMed ID: 17015698
Analysis of the C/T(-1) single nucleotide polymorphism in the CD40 gene in multiple sclerosis.
Buck D, Kroner A, Rieckmann P, Mäurer M, Wiendl H
Tissue Antigens. 2006
PubMed ID: 17026470
Plasma-soluble CD40 is related to cholesterol metabolism in patients with moderate hypercholesterolemia.
Luomala M, Päivä H, Laaksonen R, Thelen K, Lütjohann D, Peltonen N, Lehtimäki T
Scand Cardiovasc J. 2006
PubMed ID: 17012138
CD40 expression in HCV-associated chronic liver diseases.
Shiraki K, Sugimoto K, Okano H, Wagayama H, Fujikawa K, Yamanaka T, Ito T, Ohmori S, Sakai T, Takase K, Nakano T
Int J Mol Med. 2006
PubMed ID: 16964404
A novel mechanism of CD40-induced apoptosis of carcinoma cells involving TRAF3 and JNK/AP-1 activation.
Georgopoulos NT, Steele LP, Thomson MJ, Selby PJ, Southgate J, Trejdosiewicz LK
Cell Death Differ. 2006
PubMed ID: 16429118
Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease.
Enzler T, Bonizzi G, Silverman GJ, Otero DC, Widhopf GF, Anzelon-Mills A, Rickert RC, Karin M
Immunity. 2006
PubMed ID: 16973390
CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes.
Andrade RM, Wessendarp M, Gubbels MJ, Striepen B, Subauste CS
J Clin Invest. 2006
PubMed ID: 16955139
CD40/CD154 interactions are required for the optimal maturation of skin-derived APCs and the induction of helminth-specific IFN-gamma but not IL-4.
Hewitson JP, Jenkins GR, Hamblin PA, Mountford AP
J Immunol. 2006
PubMed ID: 16920960
Distinct responses of lung and spleen dendritic cells to the TLR9 agonist CpG oligodeoxynucleotide.
Chen L, Arora M, Yarlagadda M, Oriss TB, Krishnamoorthy N, Ray A, Ray P
J Immunol. 2006
PubMed ID: 16887999
Inhibitory effects of B cells on antitumor immunity.
Inoue S, Leitner WW, Golding B, Scott D
Cancer Res. 2006
PubMed ID: 16885377
Intraperitoneal Echinococcus multilocularis infection in C57BL/6 mice affects CD40 and B7 costimulator expression on peritoneal macrophages and impairs peritoneal T cell activation.
Mejri N, Gottstein B
Parasite Immunol. 2006
PubMed ID: 16879309
Chylomicron remnants upregulate CD40 expression via the ERK pathway and a redox-sensitive mechanism in THP-1 cells.
Kamemura K, Fujioka Y, Takaishi H, Takahashi A, Taniguchi T, Ishikawa Y, Yokoyama M
Atherosclerosis. 2006
PubMed ID: 16356505
Nuclear localization in the biology of the CD40 receptor in normal and neoplastic human B lymphocytes.
Lin-Lee YC, Pham LV, Tamayo AT, Fu L, Zhou HJ, Yoshimura LC, Decker GL, Ford RJ
J Biol Chem. 2006
PubMed ID: 16644731
A role for IFNgamma in differential superantigen stimulation of conventional versus plasmacytoid DCs.
Muralimohan G, Vella AT
Cell Immunol. 2006
PubMed ID: 17045255
The generation of thymus-independent germinal centers depends on CD40 but not on CD154, the T cell-derived CD40-ligand.
Gaspal FM, McConnell FM, Kim MY, Gray D, Kosco-Vilbois MH, Raykundalia CR, Botto M, Lane PJ
Eur J Immunol. 2006
PubMed ID: 16783845
Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function.
Panchanathan V, Chaudhri G, Karupiah G
J Virol. 2006
PubMed ID: 16775321
Increased levels of the CD40:CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy.
Veber D, Mutti E, Galmozzi E, Cedrola S, Galbiati S, Morabito A, Tredici G, La Porta CA, Scalabrino G
J Neuroimmunol. 2006
PubMed ID: 16716410
Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation.
Kuwajima S, Sato T, Ishida K, Tada H, Tezuka H, Ohteki T
Nat Immunol. 2006
PubMed ID: 16715101
CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system.
Chen K, Huang J, Gong W, Zhang L, Yu P, Wang JM
Cell Mol Immunol. 2006
PubMed ID: 16893496
Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells.
Chen W, Wang J, Shao C, Liu S, Yu Y, Wang Q, Cao X
Eur J Immunol. 2006
PubMed ID: 16708399
In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN.
Greene JA, DeVecchio JL, Gould MP, Auletta JJ, Heinzel FP
J Immunol. 2006
PubMed ID: 16670308
Association of a C/T single-nucleotide polymorphism in the 5' untranslated region of the CD40 gene with Graves' disease in Japanese.
Ban Y, Tozaki T, Taniyama M, Tomita M, Ban Y
Thyroid. 2006
PubMed ID: 16756465
Differential requirements of T cell subsets for CD40 costimulation in immunity to Blastomyces dermatitidis.
Wüthrich M, Fisette PL, Filutowicz HI, Klein BS
J Immunol. 2006
PubMed ID: 16622023
Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling.
Xie P, Hostager BS, Munroe ME, Moore CR, Bishop GA
J Immunol. 2006
PubMed ID: 16622006
IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia.
Qin H, Wilson CA, Lee SJ, Benveniste EN
FASEB J. 2006
PubMed ID: 16571771
CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40.
MacLeod M, Kwakkenbos MJ, Crawford A, Brown S, Stockinger B, Schepers K, Schumacher T, Gray D
J Exp Med. 2006
PubMed ID: 16549596
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects.
Havelková H, Badalová J, Svobodová M, Vojtíková J, Kurey I, Vladimirov V, Demant P, Lipoldová M
Genes Immun. 2006
PubMed ID: 16511555
Inhibition of hepatocarcinogenesis by the deletion of the p50 subunit of NF-kappaB in mice administered the peroxisome proliferator Wy-14,643.
Glauert HP, Eyigor A, Tharappel JC, Cooper S, Lee EY, Spear BT
Toxicol Sci. 2006
PubMed ID: 16434500
CD40-activated B cells express full lymph node homing triad and induce T-cell chemotaxis: potential as cellular adjuvants.
von Bergwelt-Baildon M, Shimabukuro-Vornhagen A, Popov A, Klein-Gonzalez N, Fiore F, Debey S, Draube A, Maecker B, Menezes I, Nadler LM, Schultze JL
Blood. 2006
PubMed ID: 16357329
SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells.
Réthi B, Gogolák P, Szatmari I, Veres A, Erdôs E, Nagy L, Rajnavölgyi E, Terhorst C, Lányi A
Blood. 2006
PubMed ID: 16317102
Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells.
Crawford A, Macleod M, Schumacher T, Corlett L, Gray D
J Immunol. 2006
PubMed ID: 16517718
BANK negatively regulates Akt activation and subsequent B cell responses.
Aiba Y, Yamazaki T, Okada T, Gotoh K, Sanjo H, Ogata M, Kurosaki T
Immunity. 2006
PubMed ID: 16546095
Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS).
Burdon KP, Langefeld CD, Beck SR, Wagenknecht LE, Carr JJ, Rich SS, Freedman BI, Herrington D, Bowden DW
Am Heart J. 2006
PubMed ID: 16504636
Differential regulation of chromatin structure of the murine 3' IgH enhancer and IgG2b germline promoter in response to lipopolysaccharide and CD40 signaling.
Qin X, Tang H
Mol Immunol. 2006
PubMed ID: 16099047
CD40 expression by microglial cells is required for their completion of a two-step activation process during central nervous system autoimmune inflammation.
Ponomarev ED, Shriver LP, Dittel BN
J Immunol. 2006
PubMed ID: 16424167
Circumventing tolerance at the T cell or the antigen-presenting cell surface: antibodies that ligate CD40 and OX40 have different effects.
Hochweller K, Sweenie CH, Anderton SM
Eur J Immunol. 2006
PubMed ID: 16402409
Differential expression and regulation of murine CD40 in regional vascular beds.
Vowinkel T, Wood KC, Stokes KY, Russell J, Krieglstein CF, Granger DN
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16172156
B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation.
Fujimoto M, Kuwano Y, Watanabe R, Asashima N, Nakashima H, Yoshitake S, Okochi H, Tamaki K, Poe JC, Tedder TF, Sato S
J Immunol. 2006
PubMed ID: 16393971
Dynamics of MHC class II-activating signals in murine resting B cells.
Nashar TO, Drake JR
J Immunol. 2006
PubMed ID: 16393966
TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo.
Diaz-de-Durana Y, Mantchev GT, Bram RJ, Franco A
Blood. 2006
PubMed ID: 16195331
Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells (HK-2).
Zhang YJ, Yang X, Kong QY, Zhang YF, Chen WY, Dong XQ, Li XY, Yu XQ
Am J Nephrol. 2006
PubMed ID: 16864989
CD4+ T lymphocytes expressing CD40 ligand help the IgM antibody response to soluble pneumococcal polysaccharides via an intermediate cell type.
Jeurissen A, Billiau AD, Moens L, Shengqiao L, Landuyt W, Wuyts G, Boon L, Waer M, Ceuppens JL, Bossuyt X
J Immunol. 2006
PubMed ID: 16365447
Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects.
Buhtoiarov IN, Lum HD, Berke G, Sondel PM, Rakhmilevich AL
J Immunol. 2006
PubMed ID: 16365423
Circulating CD40 ligand is elevated only in patients with more advanced symptomatic peripheral arterial diseases.
Lee WJ, Sheu WH, Chen YT, Liu TJ, Liang KW, Ting CT, Lee WL
Thromb Res. 2006
PubMed ID: 16356539
Biotinylation of heat shock protein 70 induces RANTES production in HEK293 cells in a CD40-independent pathway.
Tao Y, Nishikawa S, Nomura M, Kitabatake N, Tani F
Biochem Biophys Res Commun. 2005
PubMed ID: 16246299
Transcriptome analysis of human gastric cancer.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS
Mamm Genome. 2005
PubMed ID: 16341674
Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth.
Baxendale AJ, Dawson CW, Stewart SE, Mudaliar V, Reynolds G, Gordon J, Murray PG, Young LS, Eliopoulos AG
Oncogene. 2005
PubMed ID: 16091748
Control of B-cell responses by Toll-like receptors.
Pasare C, Medzhitov R
Nature. 2005
PubMed ID: 16292312
Antibodies and CD8+ T cells are complementary and essential for natural resistance to a highly lethal cytopathic virus.
Fang M, Sigal LJ
J Immunol. 2005
PubMed ID: 16272340
TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells.
Davies CC, Mak TW, Young LS, Eliopoulos AG
Mol Cell Biol. 2005
PubMed ID: 16260598
TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha.
Andrade RM, Wessendarp M, Portillo JA, Yang JQ, Gomez FJ, Durbin JE, Bishop GA, Subauste CS
J Immunol. 2005
PubMed ID: 16237096
CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection.
Lee BO, Rangel-Moreno J, Moyron-Quiroz JE, Hartson L, Makris M, Sprague F, Lund FE, Randall TD
J Immunol. 2005
PubMed ID: 16237075
Activation of mesangial cells by platelets in systemic lupus erythematosus via a CD154-dependent induction of CD40.
Delmas Y, Viallard JF, Solanilla A, Villeneuve J, Pasquet JM, Belloc F, Dubus I, Déchanet-Merville J, Merville P, Blanco P, Pellegrin JL, Nurden AT, Combe C, Ripoche J
Kidney Int. 2005
PubMed ID: 16221206
LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia.
Qin H, Wilson CA, Lee SJ, Zhao X, Benveniste EN
Blood. 2005
PubMed ID: 16020513
Differential effect of agonistic anti-CD40 on human mature and immature dendritic cells: the Janus face of anti-CD40.
de Goër de Herve MG, Durali D, Tran TA, Maigné G, Simonetta F, Leclerc P, Delfraissy JF, Taoufik Y
Blood. 2005
PubMed ID: 15994291
Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease.
Kurylowicz A, Kula D, Ploski R, Skorka A, Jurecka-Lubieniecka B, Zebracka J, Steinhof-Radwanska K, Hasse-Lazar K, Hiromatsu Y, Jarzab B, Bednarczuk T
Thyroid. 2005
PubMed ID: 16279844
Reduced radiosensitivity and increased CD40 expression in cyclophosphamide-resistant subclones established from human cervical squamous cell carcinoma cells.
Tanaka T, Bai T, Yukawa K, Utsunomiya T, Umesaki N
Oncol Rep. 2005
PubMed ID: 16142355
Differential regulation of CD40-mediated TNF receptor-associated factor degradation in B lymphocytes.
Moore CR, Bishop GA
J Immunol. 2005
PubMed ID: 16148124
Persistence of high CD40 and CD40L expression after restorative proctocolectomy for ulcerative colitis.
Polese L, Angriman I, Giuseppe DF, Cecchetto A, Sturniolo GC, Renata D, Scarpa M, Ruffolo C, Norberto L, Frego M, D'Amico DF
World J Gastroenterol. 2005
PubMed ID: 16149136
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
LNFPIII/LeX-stimulated macrophages activate natural killer cells via CD40-CD40L interaction.
Atochina O, Harn D
Clin Diagn Lab Immunol. 2005
PubMed ID: 16148169
Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1.
Shi S, Blumenthal A, Hickey CM, Gandotra S, Levy D, Ehrt S
J Immunol. 2005
PubMed ID: 16116224
CD40: a mediator of pro- and anti-inflammatory signals in renal tubular epithelial cells.
Laxmanan S, Datta D, Geehan C, Briscoe DM, Pal S
J Am Soc Nephrol. 2005
PubMed ID: 16033859
PSGL-1 is not required for development of experimental autoimmune encephalomyelitis.
Osmers I, Bullard DC, Barnum SR
J Neuroimmunol. 2005
PubMed ID: 16005524
The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.
Akiba H, Takeda K, Kojima Y, Usui Y, Harada N, Yamazaki T, Ma J, Tezuka K, Yagita H, Okumura K
J Immunol. 2005
PubMed ID: 16081804
A C/T polymorphism in the 5' untranslated region of the CD40 gene is associated with later onset of Graves' disease in Japanese.
Mukai T, Hiromatsu Y, Fukutani T, Ichimura M, Kaku H, Miyake I, Yamada K
Endocr J. 2005
PubMed ID: 16127217
DNFB activates MAPKs and upregulates CD40 in skin-derived dendritic cells.
Matos TJ, Duarte CB, Gonçalo M, Lopes MC
J Dermatol Sci. 2005
PubMed ID: 15896946
CD40-CD40L interactions promote neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism.
Ke ZJ, Calingasan NY, DeGiorgio LA, Volpe BT, Gibson GE
Neurochem Int. 2005
PubMed ID: 15885854
Critical role of host gammadelta T cells in experimental acute graft-versus-host disease.
Maeda Y, Reddy P, Lowler KP, Liu C, Bishop DK, Ferrara JL
Blood. 2005
PubMed ID: 15797996
Nicotinic receptors regulate B lymphocyte activation and immune response.
Skok M, Grailhe R, Changeux JP
Eur J Pharmacol. 2005
PubMed ID: 15963492
T cells from paroxysmal nocturnal haemoglobinuria (PNH) patients show an altered CD40-dependent pathway.
Terrazzano G, Sica M, Becchimanzi C, Costantini S, Rotoli B, Zappacosta S, Alfinito F, Ruggiero G
J Leukoc Biol. 2005
PubMed ID: 15817705
Constitutive expression of functional CD40 on mouse renal cancer cells: induction of Fas and Fas-mediated killing by CD40L.
Lee JK, Seki N, Sayers TJ, Subleski J, Gruys EM, Murphy WJ, Wiltrout RH
Cell Immunol. 2005
PubMed ID: 16213477
Abortive versus productive viral infection of dendritic cells with a paramyxovirus results in differential upregulation of select costimulatory molecules.
Pejawar SS, Parks GD, Alexander-Miller MA
J Virol. 2005
PubMed ID: 15919909
A Graves' disease-associated Kozak sequence single-nucleotide polymorphism enhances the efficiency of CD40 gene translation: a case for translational pathophysiology.
Jacobson EM, Concepcion E, Oashi T, Tomer Y
Endocrinology. 2005
PubMed ID: 15731360
The CD154-CD40 T-cell co-stimulation pathway in liver ischemia and reperfusion inflammatory responses.
Ke B, Shen XD, Gao F, Tsuchihashi S, Farmer DG, Briscoe D, Busuttil RW, Kupiec-Weglinski JW
Transplantation. 2005
PubMed ID: 15880047
B cell receptor (BCR) cross-talk: CD40 engagement creates an alternate pathway for BCR signaling that activates I kappa B kinase/I kappa B alpha/NF-kappa B without the need for PI3K and phospholipase C gamma.
Mizuno T, Rothstein TL
J Immunol. 2005
PubMed ID: 15879100
CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates.
Andrade RM, Portillo JA, Wessendarp M, Subauste CS
Infect Immun. 2005
PubMed ID: 15845519
Fas-ligand (CD178) and TRAIL synergistically induce apoptosis of CD40-activated chronic lymphocytic leukemia B cells.
Dicker F, Kater AP, Fukuda T, Kipps TJ
Blood. 2005
PubMed ID: 15339846
CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusion.
Ishikawa M, Vowinkel T, Stokes KY, Arumugam TV, Yilmaz G, Nanda A, Granger DN
Circulation. 2005
PubMed ID: 15795333
CD40 engagement prevents peroxisome proliferator-activated receptor gamma agonist-induced apoptosis of B lymphocytes and B lymphoma cells by an NF-kappaB-dependent mechanism.
Ray DM, Akbiyik F, Bernstein SH, Phipps RP
J Immunol. 2005
PubMed ID: 15778364
B cells can prime naive CD4+ T cells in vivo in the absence of other professional antigen-presenting cells in a CD154-CD40-dependent manner.
Rodríguez-Pinto D, Moreno J
Eur J Immunol. 2005
PubMed ID: 15756646
Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways.
Chen W, Tang Z, Fortina P, Patel P, Addya S, Surrey S, Acheampong EA, Mukhtar M, Pomerantz RJ
Virology. 2005
PubMed ID: 15749123
B cell receptor (BCR) cross-talk: CD40 engagement enhances BCR-induced ERK activation.
Mizuno T, Rothstein TL
J Immunol. 2005
PubMed ID: 15749869
TRAF-dependent association of protein kinase Tpl2/COT1 (MAP3K8) with CD40.
Chan H, Reed JC
Biochem Biophys Res Commun. 2005
PubMed ID: 15670770
Retinoic acid inhibits CD40 plus IL-4 mediated IgE production through alterations of sCD23, sCD54 and IL-6 production.
Scheffel F, Heine G, Henz BM, Worm M
Inflamm Res. 2005
PubMed ID: 15883744
Establishment and maintenance of long-term murine gammaherpesvirus 68 latency in B cells in the absence of CD40.
Willer DO, Speck SH
J Virol. 2005
PubMed ID: 15709008
Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway.
Harhaj EW, Harhaj NS, Grant C, Mostoller K, Alefantis T, Sun SC, Wigdahl B
Virology. 2005
PubMed ID: 15708600
Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ.
Anderson BE, McNiff JM, Jain D, Blazar BR, Shlomchik WD, Shlomchik MJ
Blood. 2005
PubMed ID: 15522961
Thyroid cancers express CD-40 and CD-40 ligand: cancers that express CD-40 ligand may have a greater risk of recurrence in young patients.
Costello A, Rey-Hipolito C, Patel A, Oakley K, Vasco V, Calabria C, Tuttle RM, Francis GL
Thyroid. 2005
PubMed ID: 15753667
CD40/CD40L interaction regulates CD4+CD25+ T reg homeostasis through dendritic cell-produced IL-2.
Guiducci C, Valzasina B, Dislich H, Colombo MP
Eur J Immunol. 2005
PubMed ID: 15682445
HIV-1 Vpr inhibits the maturation and activation of macrophages and dendritic cells in vitro.
Muthumani K, Hwang DS, Choo AY, Mayilvahanan S, Dayes NS, Thieu KP, Weiner DB
Int Immunol. 2005
PubMed ID: 15611322
TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages.
Mukundan L, Bishop GA, Head KZ, Zhang L, Wahl LM, Suttles J
J Immunol. 2005
PubMed ID: 15634933
TACI and BAFF-R mediate isotype switching in B cells.
Castigli E, Wilson SA, Scott S, Dedeoglu F, Xu S, Lam KP, Bram RJ, Jabara H, Geha RS
J Exp Med. 2005
PubMed ID: 15630136
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Dendritic cells activated with products released by schistosome larvae drive Th2-type immune responses, which can be inhibited by manipulation of CD40 costimulation.
Jenkins SJ, Mountford AP
Infect Immun. 2005
PubMed ID: 15618177
CD40 antisense oligonucleotide inhibition of trinitrobenzene sulphonic acid induced rat colitis.
Gao D, Wagner AH, Fankhaenel S, Stojanovic T, Schweyer S, Panzner S, Hecker M
Gut. 2005
PubMed ID: 15591506
Role of tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) in distinct and overlapping CD40 and TNF receptor 2/CD120b-mediated B lymphocyte activation.
Munroe ME, Bishop GA
J Biol Chem. 2004
PubMed ID: 15485859
Tracking CD40 signaling during germinal center development.
Basso K, Klein U, Niu H, Stolovitzky GA, Tu Y, Califano A, Cattoretti G, Dalla-Favera R
Blood. 2004
PubMed ID: 15331443
Prolactin gene expression in mouse spleen helper T cells.
Horiguchi K, Yagi S, Ono K, Nishiura Y, Tanaka M, Ishida M, Harigaya T
J Endocrinol. 2004
PubMed ID: 15590989
Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation.
Jain A, Ma CA, Lopez-Granados E, Means G, Brady W, Orange JS, Liu S, Holland S, Derry JM
J Clin Invest. 2004
PubMed ID: 15578091
Cd40 but not CD154 knockout mice have reduced inflammatory response in polymicrobial sepsis: a potential role for Escherichia coli heat shock protein 70 in CD40-mediated inflammation in vivo.
Nolan A, Weiden MD, Hoshino Y, Gold JA
Shock. 2004
PubMed ID: 15545825
CD40 ligand gene and Kawasaki disease.
Onouchi Y, Onoue S, Tamari M, Wakui K, Fukushima Y, Yashiro M, Nakamura Y, Yanagawa H, Kishi F, Ouchi K, Terai M, Hamamoto K, Kudo F, Aotsuka H, Sato Y, Nariai A, Kaburagi Y, Miura M, Saji T, Kawasaki T, Nakamura Y, Hata A
Eur J Hum Genet. 2004
PubMed ID: 15367912
Induction of endothelin-1 production in endothelial cells via co-operative action between CD40 and lectin-like oxidized LDL receptor (LOX-1).
Sakurai K, Cominacini L, Garbin U, Fratta Pasini A, Sasaki N, Takuwa Y, Masaki T, Sawamura T
J Cardiovasc Pharmacol. 2004
PubMed ID: 15838273
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Act1, a negative regulator in CD40- and BAFF-mediated B cell survival.
Qian Y, Qin J, Cui G, Naramura M, Snow EC, Ware CF, Fairchild RL, Omori SA, Rickert RC, Scott M, Kotzin BL, Li X
Immunity. 2004
PubMed ID: 15485634
Induction of cyclooxygenase-2 in reactive glial cells by the CD40 pathway: relevance to amyotrophic lateral sclerosis.
Okuno T, Nakatsuji Y, Kumanogoh A, Koguchi K, Moriya M, Fujimura H, Kikutani H, Sakoda S
J Neurochem. 2004
PubMed ID: 15447673
CD40 expression in prostate cancer: a potential diagnostic and therapeutic molecule.
Palmer DH, Hussain SA, Ganesan R, Cooke PW, Wallace DM, Young LS, James ND
Oncol Rep. 2004
PubMed ID: 15375484
Signal peptide prediction based on analysis of experimentally verified cleavage sites.
Zhang Z, Henzel WJ
Protein Sci. 2004
PubMed ID: 15340161
The development of functional CD8 T cell memory after Listeria monocytogenes infection is not dependent on CD40.
Montfort MJ, Bouwer HG, Wagner CR, Hinrichs DJ
J Immunol. 2004
PubMed ID: 15356158
Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites.
Boisvert J, Edmondson S, Krummel MF
J Immunol. 2004
PubMed ID: 15356109
CD40-CD154 interactions between macrophages and natural killer cells during sepsis are critical for macrophage activation and are not interferon gamma dependent.
Scott MJ, Hoth JJ, Stagner MK, Gardner SA, Peyton JC, Cheadle WG
Clin Exp Immunol. 2004
PubMed ID: 15320895
Cutting edge: distinct roles for T help and CD40/CD40 ligand in regulating differentiation of proliferation-competent memory CD8+ T cells.
Bachmann MF, Schwarz K, Wolint P, Meijerink E, Martin S, Manolova V, Oxenius A
J Immunol. 2004
PubMed ID: 15294930
Tuning the volume of the immune response: strength and persistence of stimulation determine migration and cytokine secretion of dendritic cells.
Luft T, Maraskovsky E, Schnurr M, Knebel K, Kirsch M, Görner M, Skoda R, Ho AD, Nawroth P, Bierhaus A
Blood. 2004
PubMed ID: 15113760
Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture.
Stunz LL, Busch LK, Munroe ME, Sigmund CD, Tygrett LT, Waldschmidt TJ, Bishop GA
Immunity. 2004
PubMed ID: 15308105
Increased CD40 expression on articular chondrocytes from patients with rheumatoid arthritis: contribution to production of cytokines and matrix metalloproteinases.
Gotoh H, Kawaguchi Y, Harigai M, Hara M, Saito S, Yamaguchi T, Shimada K, Kawamoto M, Tomatsu T, Kamatani N
J Rheumatol. 2004
PubMed ID: 15290728
A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians.
Heward JM, Simmonds MJ, Carr-Smith J, Foxall H, Franklyn JA, Gough SC
Clin Endocrinol (Oxf). 2004
PubMed ID: 15272925
CD40 activation of BCP-ALL cells generates IL-10-producing, IL-12-defective APCs that induce allogeneic T-cell anergy.
D'Amico G, Vulcano M, Bugarin C, Bianchi G, Pirovano G, Bonamino M, Marin V, Allavena P, Biagi E, Biondi A
Blood. 2004
PubMed ID: 15001471
CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development.
McKee AS, Pearce EJ
J Immunol. 2004
PubMed ID: 15240714
Role of the CD40 locus in Graves' disease.
Houston FA, Wilson V, Jennings CE, Owen CJ, Donaldson P, Perros P, Pearce SH
Thyroid. 2004
PubMed ID: 15307939
Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population.
Cho SM, Kim J, Ryu HJ, Kim JJ, Kim HH, Park JH, Kim HT, Kim KH, Cho HY, Oh B, Park C, Kimm K, Jo I, Lee JE, Shin HD, Lee JK
Hum Immunol. 2004
PubMed ID: 15301860
Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system.
Erlebacher A, Zhang D, Parlow AF, Glimcher LH
J Clin Invest. 2004
PubMed ID: 15232610
An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity.
Ruth AJ, Kitching AR, Li M, Semple TJ, Timoshanko JR, Tipping PG, Holdsworth SR
J Immunol. 2004
PubMed ID: 15210767
The role of CD40-CD154 interaction in cell immunoregulation.
Xu Y, Song G
J Biomed Sci. 2004
PubMed ID: 15153777
The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase.
Flaxenburg JA, Melter M, Lapchak PH, Briscoe DM, Pal S
J Immunol. 2004
PubMed ID: 15187129
CD40 plays a crucial role in lipopolysaccharide-induced acute lung injury.
Hashimoto N, Kawabe T, Imaizumi K, Hara T, Okamoto M, Kojima K, Shimokata K, Hasegawa Y
Am J Respir Cell Mol Biol. 2004
PubMed ID: 14693668
Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways.
Zarnegar B, He JQ, Oganesyan G, Hoffmann A, Baltimore D, Cheng G
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15148378
Ectopic CD40 ligand expression on B cells triggers intestinal inflammation.
Kawamura T, Kanai T, Dohi T, Uraushihara K, Totsuka T, Iiyama R, Taneda C, Yamazaki M, Nakamura T, Higuchi T, Aiba Y, Tsubata T, Watanabe M
J Immunol. 2004
PubMed ID: 15128830
Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses.
Mathur RK, Awasthi A, Wadhone P, Ramanamurthy B, Saha B
Nat Med. 2004
PubMed ID: 15107845
Human immunodeficiency virus (HIV) type 1 Vpu induces the expression of CD40 in endothelial cells and regulates HIV-induced adhesion of B-lymphoma cells.
Henderson WW, Ruhl R, Lewis P, Bentley M, Nelson JA, Moses AV
J Virol. 2004
PubMed ID: 15078922
Regulatory roles of N-glycosylation of immunoglobulin M in CD40-CD40L-mediated cell survival of human diffuse large B cell lymphoma.
Suzuki O, Nozawa Y, Abe M
Oncol Rep. 2004
PubMed ID: 15069543
Prognostic value of CD40 in adult soft tissue sarcomas.
Ottaiano A, De Chiara A, Perrone F, Botti G, Fazioli F, De Rosa V, Mozzillo N, Ravo V, Morrica B, Gallo C, Pisano C, Napolitano M, Ascierto PA, Iaffaioli RV, Apice G
Clin Cancer Res. 2004
PubMed ID: 15102691
Differential requirement for the CD40-CD154 costimulatory pathway during Th cell priming by CD8 alpha+ and CD8 alpha- murine dendritic cell subsets.
Yasumi T, Katamura K, Yoshioka T, Meguro TA, Nishikomori R, Heike T, Inobe M, Kon S, Uede T, Nakahata T
J Immunol. 2004
PubMed ID: 15067060
CD40 ligation in vivo induces bystander proliferation of memory phenotype CD8 T cells.
Koschella M, Voehringer D, Pircher H
J Immunol. 2004
PubMed ID: 15067057
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Systemic administration of antigen-loaded CD40-deficient dendritic cells mimics soluble antigen administration.
Hochweller K, Anderton SM
Eur J Immunol. 2004
PubMed ID: 15048709
CD154/CD40-mediated expression of CD154 in endothelial cells: consequences for endothelial cell-monocyte interaction.
Wagner AH, Güldenzoph B, Lienenlüke B, Hecker M
Arterioscler Thromb Vasc Biol. 2004
PubMed ID: 14976003
Functional caveolae are a prerequisite for CD40 signaling in human renal proximal tubule cells.
Li H, Nord EP
Am J Physiol Renal Physiol. 2004
PubMed ID: 14665433
Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells.
Sun JC, Bevan MJ
J Immunol. 2004
PubMed ID: 15004136
CD40 is necessary for activation of naïve T cells by a dendritic cell line in vivo but not in vitro.
Haase C, Michelsen BK, Jørgensen TN
Scand J Immunol. 2004
PubMed ID: 15030573
CD40 is required for the optimal induction of protective immunity to Mycobacterium avium.
Flórido M, Gonçalves AS, Gomes MS, Appelberg R
Immunology. 2004
PubMed ID: 15009433
The human antibody response to pneumococcal capsular polysaccharides is dependent on the CD40-CD40 ligand interaction.
Jeurissen A, Wuyts G, Kasran A, Ramdien-Murli S, Blanckaert N, Boon L, Ceuppens JL, Bossuyt X
Eur J Immunol. 2004
PubMed ID: 14991615
Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes.
Xie P, Hostager BS, Bishop GA
J Exp Med. 2004
PubMed ID: 14981114
Cutting edge: T cells trigger CD40-dependent platelet activation and granular RANTES release: a novel pathway for immune response amplification.
Danese S, de la Motte C, Reyes BM, Sans M, Levine AD, Fiocchi C
J Immunol. 2004
PubMed ID: 14764664
Nuclear factor kappa B-dependent activation of the antiapoptotic bfl-1 gene by the Epstein-Barr virus latent membrane protein 1 and activated CD40 receptor.
D'Souza BN, Edelstein LC, Pegman PM, Smith SM, Loughran ST, Clarke A, Mehl A, Rowe M, Gélinas C, Walls D
J Virol. 2004
PubMed ID: 14747545
Effect of beta2-adrenergic receptor agonists on intercellular adhesion molecule (ICAM)-1, B7, and CD40 expression in mixed lymphocyte reaction.
Tamura R, Takahashi HK, Iwagaki H, Yagi T, Mori S, Yoshino T, Nishibori M, Tanaka N
Transplantation. 2004
PubMed ID: 14742996
CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism.
Merluzzi S, Moretti M, Altamura S, Zwollo P, Sigvardsson M, Vitale G, Pucillo C
J Biol Chem. 2004
PubMed ID: 14594818
Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation.
Fotin-Mleczek M, Henkler F, Hausser A, Glauner H, Samel D, Graness A, Scheurich P, Mauri D, Wajant H
J Biol Chem. 2004
PubMed ID: 14557256
[Immune dysfuntion of uremic patients: potential role for the soluble form of CD40]
Contin C, Couzi L, Moreau JF, Déchanet-Merville J, Merville P
Nephrologie. 2004
PubMed ID: 15291139
CD40-mediated immune-nonimmune cell interactions induce mucosal fibroblast chemokines leading to T-cell transmigration.
Vogel JD, West GA, Danese S, De La Motte C, Phillips MH, Strong SA, Willis J, Fiocchi C
Gastroenterology. 2004
PubMed ID: 14699489
Variants in TNFRSF5 locus and association analysis with Hepatitis B virus (HBV) infection.
Zhou G, Zhai Y, Dong X, Li Y, Zhang X, Zhang R, Li S, Li X, He F, Wei H, Chen X, Yao Z, Shen Y, Qiang B, He F
Hum Mutat. 2004
PubMed ID: 14695541
Role of TNF receptor-associated factor 3 in the CD40 signaling by production of reactive oxygen species through association with p40phox, a cytosolic subunit of nicotinamide adenine dinucleotide phosphate oxidase.
Ha YJ, Lee JR
J Immunol. 2004
PubMed ID: 14688330
Upregulation of CD40--CD40 ligand system in patients with diabetes mellitus.
Jinchuan Y, Zonggui W, Jinming C, Li L, Xiantao K
Clin Chim Acta. 2004
PubMed ID: 14687897
Molecular regulation of CD40 gene expression in macrophages and microglia.
Benveniste EN, Nguyen VT, Wesemann DR
Brain Behav Immun. 2004
PubMed ID: 14651941
Signaling and protein associations of a cell permeable CD40 complex in B cells.
Zoog SJ, Papov VV, Pullen SS, Jakes S, Kehry MR
Mol Immunol. 2004
PubMed ID: 14644094
CD40-induced aggregation of MHC class II and CD80 on the cell surface leads to an early enhancement in antigen presentation.
Clatza A, Bonifaz LC, Vignali DA, Moreno J
J Immunol. 2003
PubMed ID: 14662847
Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling.
Li C, Norris PS, Ni CZ, Havert ML, Chiong EM, Tran BR, Cabezas E, Reed JC, Satterthwait AC, Ware CF, Ely KR
J Biol Chem. 2003
PubMed ID: 14517219
CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection.
Lazarevic V, Myers AJ, Scanga CA, Flynn JL
Immunity. 2003
PubMed ID: 14670300
CD40-deficient, influenza-specific CD8 memory T cells develop and function normally in a CD40-sufficient environment.
Lee BO, Hartson L, Randall TD
J Exp Med. 2003
PubMed ID: 14657225
CD40, but not CD154, expression on B cells is necessary for optimal primary B cell responses.
Lee BO, Moyron-Quiroz J, Rangel-Moreno J, Kusser KL, Hartson L, Sprague F, Lund FE, Randall TD
J Immunol. 2003
PubMed ID: 14634078
Major involvement of CD40 in the regulation of chemokine secretion from human peritoneal mesothelial cells.
Man L, Lewis E, Einbinder T, Rogachev B, Chaimovitz C, Douvdevani A
Kidney Int. 2003
PubMed ID: 14633128
Stimulation of CD40 inhibits Fas- or chemotherapy-mediated apoptosis and increases cell motility in human gastric carcinoma cells.
Yamaguchi H, Tanaka F, Sadanaga N, Ohta M, Inoue H, Mori M
Int J Oncol. 2003
PubMed ID: 14612943
Functional defects of dendritic cells in patients with CD40 deficiency.
Fontana S, Moratto D, Mangal S, De Francesco M, Vermi W, Ferrari S, Facchetti F, Kutukculer N, Fiorini C, Duse M, Das PK, Notarangelo LD, Plebani A, Badolato R
Blood. 2003
PubMed ID: 12893749
Impaired germinal center maturation in adenosine deaminase deficiency.
Aldrich MB, Chen W, Blackburn MR, Martinez-Valdez H, Datta SK, Kellems RE
J Immunol. 2003
PubMed ID: 14607964
CD40 signaling through a newly identified tumor necrosis factor receptor-associated factor 2 (TRAF2) binding site.
Lu LF, Cook WJ, Lin LL, Noelle RJ
J Biol Chem. 2003
PubMed ID: 12960157
Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling.
Hostager BS, Haxhinasto SA, Rowland SL, Bishop GA
J Biol Chem. 2003
PubMed ID: 12958312
Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions.
Grammer AC, Slota R, Fischer R, Gur H, Girschick H, Yarboro C, Illei GG, Lipsky PE
J Clin Invest. 2003
PubMed ID: 14617752
CD40 stimulation of human peripheral B lymphocytes: distinct response from naive and memory cells.
Fecteau JF, Néron S
J Immunol. 2003
PubMed ID: 14568936
Role of nod2 in the response of macrophages to toll-like receptor agonists.
Pauleau AL, Murray PJ
Mol Cell Biol. 2003
PubMed ID: 14560001
Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis.
Zazzeroni F, Papa S, Algeciras-Schimnich A, Alvarez K, Melis T, Bubici C, Majewski N, Hay N, De Smaele E, Peter ME, Franzoso G
Blood. 2003
PubMed ID: 12855571
A C/T polymorphism in the 5'-untranslated region of the CD40 gene is associated with Graves' disease in Koreans.
Kim TY, Park YJ, Hwang JK, Song JY, Park KS, Cho BY, Park DJ
Thyroid. 2003
PubMed ID: 14611700
Kinetics and signaling requirements of CD40-mediated protection from B cell receptor-induced apoptosis.
Eeva J, Postila V, Mättö M, Nuutinen U, Ropponen A, Eray M, Pelkonen J
Eur J Immunol. 2003
PubMed ID: 14515262
Blockade of CD40-CD40 ligand protects against renal injury in chronic proteinuric renal disease.
Kairaitis L, Wang Y, Zheng L, Tay YC, Wang Y, Harris DC
Kidney Int. 2003
PubMed ID: 12969144
Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40-mediated interleukin-12 synthesis in human endothelial cells.
Cattaruzza M, Słodowski W, Stojakovic M, Krzesz R, Hecker M
J Biol Chem. 2003
PubMed ID: 12857749
A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis.
Longo CR, Arvelo MB, Patel VI, Daniel S, Mahiou J, Grey ST, Ferran C
Circulation. 2003
PubMed ID: 12885753
Functional plasticity of dendritic cell subsets as mediated by CD40 versus B7 activation.
Grohmann U, Bianchi R, Orabona C, Fallarino F, Vacca C, Micheletti A, Fioretti MC, Puccetti P
J Immunol. 2003
PubMed ID: 12928409
Membrane-anchored CD40 is processed by the tumor necrosis factor-alpha-converting enzyme. Implications for CD40 signaling.
Contin C, Pitard V, Itai T, Nagata S, Moreau JF, Déchanet-Merville J
J Biol Chem. 2003
PubMed ID: 12810728
Inhibitory coreceptors activated by antigens but not by anti-Ig heavy chain antibodies install requirement of costimulation through CD40 for survival and proliferation of B cells.
Hokazono Y, Adachi T, Wabl M, Tada N, Amagasa T, Tsubata T
J Immunol. 2003
PubMed ID: 12902484
Dendritic cell uptake of human apoptotic and necrotic neutrophils inhibits CD40, CD80, and CD86 expression and reduces allogeneic T cell responses: relevance to systemic vasculitis.
Clayton AR, Prue RL, Harper L, Drayson MT, Savage CO
Arthritis Rheum. 2003
PubMed ID: 12905492
T-bet regulates T-independent IgG2a class switching.
Gerth AJ, Lin L, Peng SL
Int Immunol. 2003
PubMed ID: 12882831
Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.
Eliopoulos AG, Wang CC, Dumitru CD, Tsichlis PN
EMBO J. 2003
PubMed ID: 12881420
Proangiogenic function of CD40 ligand-CD40 interactions.
Reinders ME, Sho M, Robertson SW, Geehan CS, Briscoe DM
J Immunol. 2003
PubMed ID: 12874247
Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo.
Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, Mohrs M, Locksley RM, Kronenberg M
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12829795
Increased susceptibility to airway responses in CD40-deficient mice.
Takahashi H, Ebihara S, Kanda A, Kamanaka M, Sato T, Habu S, Kikutani H, Sasaki H
Clin Exp Immunol. 2003
PubMed ID: 12823274
Recent advances on the role of CD40 and dendritic cells in immunity and tolerance.
O'Sullivan B, Thomas R
Curr Opin Hematol. 2003
PubMed ID: 12799532
Cross-species costimulation: relative contributions of CD80, CD86, and CD40.
Rogers NJ, Jackson IM, Jordan WJ, Hawadle MA, Dorling A, Lechler RI
Transplantation. 2003
PubMed ID: 12829914
CD40-dependent and -independent activation of human tonsil B cells by CpG oligodeoxynucleotides.
Gantner F, Hermann P, Nakashima K, Matsukawa S, Sakai K, Bacon KB
Eur J Immunol. 2003
PubMed ID: 12778475
Upregulation of CD40-CD40 ligand (CD154) in patients with acute cerebral ischemia.
Garlichs CD, Kozina S, Fateh-Moghadam S, Handschu R, Tomandl B, Stumpf C, Eskafi S, Raaz D, Schmeisser A, Yilmaz A, Ludwig J, Neundörfer B, Daniel WG
Stroke. 2003
PubMed ID: 12764232
A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
Buhlmann JE, Elkin SK, Sharpe AH
J Immunol. 2003
PubMed ID: 12759417
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S
Oncogene. 2003
PubMed ID: 12761501
CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation.
Inwald DP, McDowall A, Peters MJ, Callard RE, Klein NJ
Circ Res. 2003
PubMed ID: 12676820
CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis.
Deregibus MC, Buttiglieri S, Russo S, Bussolati B, Camussi G
J Biol Chem. 2003
PubMed ID: 12637493
CD40 signaling is impaired in L. major-infected macrophages and is rescued by a p38MAPK activator establishing a host-protective memory T cell response.
Awasthi A, Mathur R, Khan A, Joshi BN, Jain N, Sawant S, Boppana R, Mitra D, Saha B
J Exp Med. 2003
PubMed ID: 12695487
The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation.
Brown SA, Richards CM, Hanscom HN, Feng SL, Winkles JA
Biochem J. 2003
PubMed ID: 12529173
Differential induction of nuclear factor-kappaB and activator protein-1 activity after CD40 ligation is associated with primary human hepatocyte apoptosis or intrahepatic endothelial cell proliferation.
Ahmed-Choudhury J, Russell CL, Randhawa S, Young LS, Adams DH, Afford SC, Choudhury JA
Mol Biol Cell. 2003
PubMed ID: 12686591
CD40 can costimulate human memory T cells and favors IL-10 secretion.
Rogers NJ, Jackson IM, Jordan WJ, Lombardi G, Delikouras A, Lechler RI
Eur J Immunol. 2003
PubMed ID: 12672076
CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling.
Tai YT, Podar K, Mitsiades N, Lin B, Mitsiades C, Gupta D, Akiyama M, Catley L, Hideshima T, Munshi NC, Treon SP, Anderson KC
Blood. 2003
PubMed ID: 12433678
CD40 ligand trimer enhances the response of CD8+ T cells to Mycobacterium tuberculosis.
Samten B, Wizel B, Shams H, Weis SE, Klucar P, Wu S, Vankayalapati R, Thomas EK, Okada S, Krensky AM, Barnes PF
J Immunol. 2003
PubMed ID: 12626576
Cutting edge: CD40 engagement eliminates the need for Bruton's tyrosine kinase in B cell receptor signaling for NF-kappa B.
Mizuno T, Rothstein TL
J Immunol. 2003
PubMed ID: 12626529
Strong expression of CD40, CD54 and HLA-DR antigen and lack of evidence for direct cellular cytotoxicity are unique immunohistopathological features in alopecia areata.
Sato-Kawamura M, Aiba S, Tagami H
Arch Dermatol Res. 2003
PubMed ID: 12624779
Distinct contributions of different CD40 TRAF binding sites to CD154-induced dendritic cell maturation and IL-12 secretion.
Mackey MF, Wang Z, Eichelberg K, Germain RN
Eur J Immunol. 2003
PubMed ID: 12616498
CD40 triggering enhances fludarabine-induced apoptosis of chronic lymphocytic leukemia B-cells through autocrine release of tumor necrosis factor-alpha and interferon-gama and tumor necrosis factor receptor-I-II upregulation.
de Totero D, Tazzari PL, Capaia M, Montera MP, Clavio M, Balleari E, Foa R, Gobbi M
Haematologica. 2003
PubMed ID: 12604404
Disseminated cryptosporidium infection in an infant with hyper-IgM syndrome caused by CD40 deficiency.
Kutukculer N, Moratto D, Aydinok Y, Lougaris V, Aksoylar S, Plebani A, Genel F, Notarangelo LD
J Pediatr. 2003
PubMed ID: 12584544
Immunohistochemical expression of CD23 and CD40 may identify prognostically favorable subgroups of diffuse large B-cell lymphoma: a Nordic Lymphoma Group Study.
Linderoth J, Jerkeman M, Cavallin-Ståhl E, Kvaløy S, Torlakovic E, Nordic Lymphoma Group Study
Clin Cancer Res. 2003
PubMed ID: 12576441
CD40 is expressed on ovarian cancer cells and can be utilized for targeting adenoviruses.
Hakkarainen T, Hemminki A, Pereboev AV, Barker SD, Asiedu CK, Strong TV, Kanerva A, Wahlfors J, Curiel DT
Clin Cancer Res. 2003
PubMed ID: 12576427
T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation.
Fillatreau S, Gray D
J Exp Med. 2003
PubMed ID: 12538659
Differential requirements for expression of CD80/86 and CD40 on B cells for T-dependent antibody responses in vivo.
Lumsden JM, Williams JA, Hodes RJ
J Immunol. 2003
PubMed ID: 12517941
Mouse endothelial CD40 expression does not play a role during the development of transplant arteriosclerosis.
Ensminger SM, Spriewald BM, Fischlein T, Weyand M, Morris PJ, Wood KJ
Endothelium. 2003
PubMed ID: 12791519
Differential regulation of cell survival by CD40.
Dallman C, Johnson PW, Packham G
Apoptosis. 2003
PubMed ID: 12510151
CD40 expressed by human brain endothelial cells regulates CD4+ T cell adhesion to endothelium.
Omari KM, Dorovini-Zis K
J Neuroimmunol. 2003
PubMed ID: 12507785
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
CD27 and CD40 inhibit p53-independent mitochondrial pathways in apoptosis of B cells induced by B cell receptor ligation.
Hase H, Kanno Y, Kojima H, Morimoto C, Okumura K, Kobata T
J Biol Chem. 2002
PubMed ID: 12324477
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
A C/T single-nucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease.
Tomer Y, Concepcion E, Greenberg DA
Thyroid. 2002
PubMed ID: 12593727
CD40 ligation and phagocytosis differently affect the differentiation of monocytes into dendritic cells.
Rosenzwajg M, Jourquin F, Tailleux L, Gluckman JC
J Leukoc Biol. 2002
PubMed ID: 12488500
Involvement of CD40-CD40L signaling in postischemic lung injury.
Moore TM, Shirah WB, Khimenko PL, Paisley P, Lausch RN, Taylor AE
Am J Physiol Lung Cell Mol Physiol. 2002
PubMed ID: 12388354
Significance of chemokines and soluble CD40 ligand in patients with autoimmune thrombocytopenic purpura.
Nagahama M, Nomura S, Kanazawa S, Ozaki Y, Kagawa H, Fukuhara S
Eur J Haematol. 2002
PubMed ID: 12460235
CD40-mediated apoptosis in murine B-lymphoma lines containing mutated p53.
Hollmann AC, Gong Q, Owens T
Exp Cell Res. 2002
PubMed ID: 12413886
CD40 regulates the processing of NF-kappaB2 p100 to p52.
Coope HJ, Atkinson PG, Huhse B, Belich M, Janzen J, Holman MJ, Klaus GG, Johnston LH, Ley SC
EMBO J. 2002
PubMed ID: 12374738
CD40-mediated activation of NF-kappa B in airway epithelial cells.
Propst SM, Estell K, Schwiebert LM
J Biol Chem. 2002
PubMed ID: 12122011
Bruton's tyrosine kinase is activated upon CD40 stimulation in human B lymphocytes.
Brunner C, Avots A, Kreth HW, Serfling E, Schuster V
Immunobiology. 2002
PubMed ID: 12437073
CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes.
Becker T, Hartl FU, Wieland F
J Cell Biol. 2002
PubMed ID: 12356871
A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory.
Bourgeois C, Rocha B, Tanchot C
Science. 2002
PubMed ID: 12242444
Impact of both donor and recipient strains on cardiac allograft survival after blockade of the CD40-CD154 costimulatory pathway.
van Maurik A, Wood KJ, Jones ND
Transplantation. 2002
PubMed ID: 12352896
CD40-mediated tumor necrosis factor receptor-associated factor 3 signaling upregulates IL-4-induced germline Cepsilon transcription in a human B cell line.
Basaki Y, Ikizawa K, Kajiwara K, Yanagihara Y
Arch Biochem Biophys. 2002
PubMed ID: 12220533
Cutting edge: the relative distribution of T cells responding to chemically dominant or minor epitopes of lysozyme is not affected by CD40-CD40 ligand and B7-CD28-CTLA-4 costimulatory pathways.
DiPaolo RJ, Unanue ER
J Immunol. 2002
PubMed ID: 12218093
The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and janus kinase (JAK)/STAT signaling pathways.
Burysek L, Syrovets T, Simmet T
J Biol Chem. 2002
PubMed ID: 12093796
The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: reciprocal regulation by interleukin (IL)-4 and IL-12.
Lee BO, Haynes L, Eaton SM, Swain SL, Randall TD
J Exp Med. 2002
PubMed ID: 12208883
The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching.
Jabara H, Laouini D, Tsitsikov E, Mizoguchi E, Bhan A, Castigli E, Dedeoglu F, Pivniouk V, Brodeur S, Geha R
Immunity. 2002
PubMed ID: 12354380
Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production.
Nemoto E, Tada H, Shimauchi H
J Leukoc Biol. 2002
PubMed ID: 12223522
Inhibition of CD40 expression and CD40-mediated dendritic cell function by tumor-derived IL-10.
Shurin MR, Yurkovetsky ZR, Tourkova IL, Balkir L, Shurin GV
Int J Cancer. 2002
PubMed ID: 12209589
CD40 engagement enhances eosinophil survival through induction of cellular inhibitor of apoptosis protein 2 expression: Possible involvement in allergic inflammation.
Bureau F, Seumois G, Jaspar F, Vanderplasschen A, Detry B, Pastoret PP, Louis R, Lekeux P
J Allergy Clin Immunol. 2002
PubMed ID: 12209092
CD40-mediated p38 mitogen-activated protein kinase activation is required for immunoglobulin class switch recombination to IgE.
Zhang K, Zhang L, Zhu D, Bae D, Nel A, Saxon A
J Allergy Clin Immunol. 2002
PubMed ID: 12209089
Human lung myofibroblasts as effectors of the inflammatory process: the common receptor gamma chain is induced by Th2 cytokines, and CD40 ligand is induced by lipopolysaccharide, thrombin and TNF-alpha.
Doucet C, Giron-Michel J, Canonica GW, Azzarone B
Eur J Immunol. 2002
PubMed ID: 12207328
Activation of APCs through CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune disease.
Ichikawa HT, Williams LP, Segal BM
J Immunol. 2002
PubMed ID: 12193753
Clustering of CD40 ligand is required to form a functional contact with CD40.
Grassmé H, Bock J, Kun J, Gulbins E
J Biol Chem. 2002
PubMed ID: 12011072
CD154-CD40 T-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection.
Shen XD, Ke B, Zhai Y, Amersi F, Gao F, Anselmo DM, Busuttil RW, Kupiec-Weglinski JW
Transplantation. 2002
PubMed ID: 12177608
Efficient generation of antigen-specific cytotoxic T cells using retrovirally transduced CD40-activated B cells.
Kondo E, Topp MS, Kiem HP, Obata Y, Morishima Y, Kuzushima K, Tanimoto M, Harada M, Takahashi T, Akatsuka Y
J Immunol. 2002
PubMed ID: 12165546
4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8 T cells in a CD40-dependent manner.
Miller RE, Jones J, Le T, Whitmore J, Boiani N, Gliniak B, Lynch DH
J Immunol. 2002
PubMed ID: 12165501
Differential involvement of CD40, CD80, and major histocompatibility complex class I molecules in cytotoxicity induction and interferon-gamma production by human natural killer effectors.
Terrazzano G, Zanzi D, Palomba C, Carbone E, Grimaldi S, Pisanti S, Fontana S, Zappacosta S, Ruggiero G
J Leukoc Biol. 2002
PubMed ID: 12149421
MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses.
VanLith ML, Kohlgraf KG, Sivinski CL, Tempero RM, Hollingsworth MA
Int Immunol. 2002
PubMed ID: 12147624
Distinct molecular mechanism for initiating TRAF6 signalling.
Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H
Nature. 2002
PubMed ID: 12140561
Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells.
Qian Y, Zhao Z, Jiang Z, Li X
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12089335
Activation-induced cell death of aggressive histology lymphomas by CD40 stimulation: induction of bax.
Szocinski JL, Khaled AR, Hixon J, Halverson D, Funakoshi S, Fanslow WC, Boyd A, Taub DD, Durum SK, Siegall CB, Longo DL, Murphy WJ
Blood. 2002
PubMed ID: 12070030
Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell.
Taylor PA, Friedman TM, Korngold R, Noelle RJ, Blazar BR
Blood. 2002
PubMed ID: 12036894
CD40 ligation-induced cytokine production in human skin explants is partly mediated via IL-1.
Companjen AR, van der Wel LI, Boon L, Prens EP, Laman JD
Int Immunol. 2002
PubMed ID: 12039918
CD40 ligation stimulates MCP-1 and IL-8 production, TRAF6 recruitment, and MAPK activation in proximal tubule cells.
Li H, Nord EP
Am J Physiol Renal Physiol. 2002
PubMed ID: 11997318
CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1.
Mann J, Oakley F, Johnson PW, Mann DA
J Biol Chem. 2002
PubMed ID: 11886848
CD40/CD40 ligand interactions in the host defense against disseminated Candida albicans infection: the role of macrophage-derived nitric oxide.
Netea MG, Meer JW, Verschueren I, Kullberg BJ
Eur J Immunol. 2002
PubMed ID: 11981834
Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction.
MacDonald AS, Patton EA, La Flamme AC, Araujo MI, Huxtable CR, Bauman B, Pearce EJ
J Immunol. 2002
PubMed ID: 11971013
The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells.
Ahonen C, Manning E, Erickson LD, O'Connor B, Lind EF, Pullen SS, Kehry MR, Noelle RJ
Nat Immunol. 2002
PubMed ID: 11967542
Critical role of tumor necrosis factor-alpha and NF-kappa B in interferon-gamma -induced CD40 expression in microglia/macrophages.
Nguyen VT, Benveniste EN
J Biol Chem. 2002
PubMed ID: 11830590
CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity.
van Mierlo GJ, den Boer AT, Medema JP, van der Voort EI, Fransen MF, Offringa R, Melief CJ, Toes RE
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11929985
Role of TNF receptor-associated factor 2 in the activation of IgM secretion by CD40 and CD120b.
Hostager BS, Bishop GA
J Immunol. 2002
PubMed ID: 11907088
Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia.
Chu P, Deforce D, Pedersen IM, Kim Y, Kitada S, Reed JC, Kipps TJ
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11891278
Involvement of receptor-interacting protein 2 in innate and adaptive immune responses.
Chin AI, Dempsey PW, Bruhn K, Miller JF, Xu Y, Cheng G
Nature. 2002
PubMed ID: 11894097
Downstream regulator TANK binds to the CD40 recognition site on TRAF3.
Li C, Ni CZ, Havert ML, Cabezas E, He J, Kaiser D, Reed JC, Satterthwait AC, Cheng G, Ely KR
Structure. 2002
PubMed ID: 12005438
CD40/CD40L interaction is essential for the induction of EAE in the absence of CD28-mediated co-stimulation.
Girvin AM, Dal Canto MC, Miller SD
J Autoimmun. 2002
PubMed ID: 11908941
Short-circuiting long-lived humoral immunity by the heightened engagement of CD40.
Erickson LD, Durell BG, Vogel LA, O'Connor BP, Cascalho M, Yasui T, Kikutani H, Noelle RJ
J Clin Invest. 2002
PubMed ID: 11877469
CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism.
André P, Prasad KS, Denis CV, He M, Papalia JM, Hynes RO, Phillips DR, Wagner DD
Nat Med. 2002
PubMed ID: 11875495
CD40/CD154 ligation is required for the development of acute ileitis following oral infection with an intracellular pathogen in mice.
Li W, Buzoni-Gatel D, Debbabi H, Hu MS, Mennechet FJ, Durell BG, Noelle RJ, Kasper LH
Gastroenterology. 2002
PubMed ID: 11875009
The selective triggering of CD40 on keratinocytes in vivo enhances cell-mediated immunity.
Fuller BW, Nishimura T, Noelle RJ
Eur J Immunol. 2002
PubMed ID: 11870634
Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals.
Yasui T, Muraoka M, Takaoka-Shichijo Y, Ishida I, Takegahara N, Uchida J, Kumanogoh A, Suematsu S, Suzuki M, Kikutani H
Int Immunol. 2002
PubMed ID: 11867568
CD40 is expressed and functional on neuronal cells.
Tan J, Town T, Mori T, Obregon D, Wu Y, DelleDonne A, Rojiani A, Crawford F, Flavell RA, Mullan M
EMBO J. 2002
PubMed ID: 11847112
CD40 activation induces p53-dependent vascular endothelial growth factor secretion in human multiple myeloma cells.
Tai YT, Podar K, Gupta D, Lin B, Young G, Akiyama M, Anderson KC
Blood. 2002
PubMed ID: 11830495
CD40 on salivary gland epithelial cells: high constitutive expression by cultured cells from Sjögren's syndrome patients indicating their intrinsic activation.
Dimitriou ID, Kapsogeorgou EK, Moutsopoulos HM, Manoussakis MN
Clin Exp Immunol. 2002
PubMed ID: 11876766
Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease.
Tamada K, Tamura H, Flies D, Fu YX, Celis E, Pease LR, Blazar BR, Chen L
J Clin Invest. 2002
PubMed ID: 11854328
Does CD40 ligation induce B cell negative selection?
Martínez-Barnetche J, Madrid-Marina V, Flavell RA, Moreno J
J Immunol. 2002
PubMed ID: 11801637
Cutting edge: Th2 response induction by dendritic cells: a role for CD40.
MacDonald AS, Straw AD, Dalton NM, Pearce EJ
J Immunol. 2002
PubMed ID: 11777943
CD40 signaling and autoimmunity.
Cheng G, Schoenberger SP
Curr Dir Autoimmun. 2002
PubMed ID: 11826760
CD40-CD40 ligand disruption does not prevent hyperoxia-induced injury.
Barazzone Argiroffo C, Donati YR, Boccard J, Rochat AF, Vesin C, Kan CD, Piguet PF
Am J Pathol. 2002
PubMed ID: 11786400
Ceramide-rich membrane rafts mediate CD40 clustering.
Grassmé H, Jendrossek V, Bock J, Riehle A, Gulbins E
J Immunol. 2002
PubMed ID: 11751974
Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses.
Fanales-Belasio E, Moretti S, Nappi F, Barillari G, Micheletti F, Cafaro A, Ensoli B
J Immunol. 2002
PubMed ID: 11751963
Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease.
Higuchi T, Aiba Y, Nomura T, Matsuda J, Mochida K, Suzuki M, Kikutani H, Honjo T, Nishioka K, Tsubata T
J Immunol. 2002
PubMed ID: 11751940
The DNA sequence and comparative analysis of human chromosome 20.
Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J
Nature. 2001
PubMed ID: 11780052
Characterization of a CD40-dominant inhibitory receptor mutant.
Mehl AM, Jones M, Rowe M, Brennan P
J Immunol. 2001
PubMed ID: 11714804
Human B cell activation by autologous NK cells is regulated by CD40-CD40 ligand interaction: role of memory B cells and CD5+ B cells.
Blanca IR, Bere EW, Young HA, Ortaldo JR
J Immunol. 2001
PubMed ID: 11714772
CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways.
Foey AD, Feldmann M, Brennan FM
Cytokine. 2001
PubMed ID: 11792123
Molecular characterization of CD40 signaling intermediates.
Werneburg BG, Zoog SJ, Dang TT, Kehry MR, Crute JJ
J Biol Chem. 2001
PubMed ID: 11562359
Homeostatic expansion occurs independently of costimulatory signals.
Prlic M, Blazar BR, Khoruts A, Zell T, Jameson SC
J Immunol. 2001
PubMed ID: 11698438
Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells.
Khandekar SS, Silverman C, Wells-Marani J, Bacon AM, Birrell H, Brigham-Burke M, DeMarini DJ, Jonak ZL, Camilleri P, Fishman-Lobell J
Protein Expr Purif. 2001
PubMed ID: 11676606
Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM.
Ferrari S, Giliani S, Insalaco A, Al-Ghonaium A, Soresina AR, Loubser M, Avanzini MA, Marconi M, Badolato R, Ugazio AG, Levy Y, Catalan N, Durandy A, Tbakhi A, Notarangelo LD, Plebani A
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11675497
Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis.
Ndhlovu LC, Ishii N, Murata K, Sato T, Sugamura K
J Immunol. 2001
PubMed ID: 11509650
Role of CD40-CVD40L in mouse severe malaria.
Piguet PF, Kan CD, Vesin C, Rochat A, Donati Y, Barazzone C
Am J Pathol. 2001
PubMed ID: 11485931
Critical role for IL-4 in the development of transplant arteriosclerosis in the absence of CD40-CD154 costimulation.
Ensminger SM, Spriewald BM, Sorensen HV, Witzke O, Flashman EG, Bushell A, Morris PJ, Rose ML, Rahemtulla A, Wood KJ
J Immunol. 2001
PubMed ID: 11418692
Stimulation via CD40 can substitute for CD4 T cell function in preventing reactivation of a latent herpesvirus.
Sarawar SR, Lee BJ, Reiter SK, Schoenberger SP
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11353832
Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways.
Hayakawa Y, Takeda K, Yagita H, Van Kaer L, Saiki I, Okumura K
J Immunol. 2001
PubMed ID: 11342617
Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA.
Siddiqa A, Sims-Mourtada JC, Guzman-Rojas L, Rangel R, Guret C, Madrid-Marina V, Sun Y, Martinez-Valdez H
Nature. 2001
PubMed ID: 11268217
Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection.
Pope C, Kim SK, Marzo A, Masopust D, Williams K, Jiang J, Shen H, Lefrançois L
J Immunol. 2001
PubMed ID: 11207297
The TNF and TNF receptor superfamilies: integrating mammalian biology.
Locksley RM, Killeen N, Lenardo MJ
Cell. 2001
PubMed ID: 11239407
Signals that initiate somatic hypermutation of B cells in vitro.
Bergthorsdottir S, Gallagher A, Jainandunsing S, Cockayne D, Sutton J, Leanderson T, Gray D
J Immunol. 2001
PubMed ID: 11160276
Regulation of CD40 function by its isoforms generated through alternative splicing.
Tone M, Tone Y, Fairchild PJ, Wykes M, Waldmann H
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11172023
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis.
Woodward AL, Spergel JM, Alenius H, Mizoguchi E, Bhan AK, Castigli E, Brodeur SR, Oettgen HC, Geha RS
J Allergy Clin Immunol. 2001
PubMed ID: 11174205
The Common vaccine adjuvant aluminum hydroxide up-regulates accessory properties of human monocytes via an interleukin-4-dependent mechanism.
Ulanova M, Tarkowski A, Hahn-Zoric M, Hanson LA
Infect Immun. 2001
PubMed ID: 11160013
CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes.
Bhushan A, Covey LR
Immunol Res. 2001
PubMed ID: 11817328
Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development.
Kumanogoh A, Wang X, Lee I, Watanabe C, Kamanaka M, Shi W, Yoshida K, Sato T, Habu S, Itoh M, Sakaguchi N, Sakaguchi S, Kikutani H
J Immunol. 2001
PubMed ID: 11123312
Interleukin-12 counterbalances the deleterious effect of human immunodeficiency virus type 1 envelope glycoprotein gp120 on the immune response to Cryptococcus neoformans.
Pietrella D, Kozel TR, Monari C, Bistoni F, Vecchiarelli A
J Infect Dis. 2001
PubMed ID: 11087201
Identification of mature and immature human thymic dendritic cells that differentially express HLA-DR and interleukin-3 receptor in vivo.
Schmitt C, Fohrer H, Beaudet S, Palmer P, Alpha MJ, Canque B, Gluckman JC, Dalloul AH
J Leukoc Biol. 2000
PubMed ID: 11129651
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5.
Sexl V, Piekorz R, Moriggl R, Rohrer J, Brown MP, Bunting KD, Rothammer K, Roussel MF, Ihle JN
Blood. 2000
PubMed ID: 10979977
Molecular basis for CD40 signaling mediated by TRAF3.
Ni CZ, Welsh K, Leo E, Chiou CK, Wu H, Reed JC, Ely KR
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10984535
Involvement of STAT-1 and ets family members in interferon-gamma induction of CD40 transcription in microglia/macrophages.
Nguyen VT, Benveniste EN
J Biol Chem. 2000
PubMed ID: 10823830
The antigen dose determines T helper subset development by regulation of CD40 ligand.
Ruedl C, Bachmann MF, Kopf M
Eur J Immunol. 2000
PubMed ID: 10940895
TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.
Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE
J Biol Chem. 2000
PubMed ID: 10764746
CD40-CD40 ligand interactions in vivo regulate migration of antigen-bearing dendritic cells from the skin to draining lymph nodes.
Moodycliffe AM, Shreedhar V, Ullrich SE, Walterscheid J, Bucana C, Kripke ML, Flores-Romo L
J Exp Med. 2000
PubMed ID: 10839815
Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2.
Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW
Mol Endocrinol. 2000
PubMed ID: 10847592
Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction.
Lode HN, Xiang R, Pertl U, Förster E, Schoenberger SP, Gillies SD, Reisfeld RA
J Clin Invest. 2000
PubMed ID: 10841521
Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling.
Hostager BS, Catlett IM, Bishop GA
J Biol Chem. 2000
PubMed ID: 10748139
CD40 ligand in CLL pathogenesis and therapy.
Schattner EJ
Leuk Lymphoma. 2000
PubMed ID: 11042507
Dendritic cell-B-cell interaction: dendritic cells provide B cells with CD40-independent proliferation signals and CD40-dependent survival signals.
Wykes M, MacPherson G
Immunology. 2000
PubMed ID: 10809952
Regulatory role of mature B cells in a murine model of inflammatory bowel disease.
Mizoguchi E, Mizoguchi A, Preffer FI, Bhan AK
Int Immunol. 2000
PubMed ID: 10784605
Eradication of Cryptosporidium parvum infection by mice with ovalbumin-specific T cells.
Lukin K, Cosyns M, Mitchell T, Saffry M, Hayward A
Infect Immun. 2000
PubMed ID: 10768958
Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRgamma-deficient mice.
Wakayama H, Hasegawa Y, Kawabe T, Hara T, Matsuo S, Mizuno M, Takai T, Kikutani H, Shimokata K
Eur J Immunol. 2000
PubMed ID: 10760808
Chemokines and CD40 expression in human fibroblasts.
Brouty-Boyé D, Pottin-Clémenceau C, Doucet C, Jasmin C, Azzarone B
Eur J Immunol. 2000
PubMed ID: 10741409
CD40-independent pathways of T cell help for priming of CD8(+) cytotoxic T lymphocytes.
Lu Z, Yuan L, Zhou X, Sotomayor E, Levitsky HI, Pardoll DM
J Exp Med. 2000
PubMed ID: 10662799
Resting B lymphocytes as APC for naive T lymphocytes: dependence on CD40 ligand/CD40.
Evans DE, Munks MW, Purkerson JM, Parker DC
J Immunol. 2000
PubMed ID: 10623811
CD40-CD40 ligand.
van Kooten C, Banchereau J
J Leukoc Biol. 2000
PubMed ID: 10647992
Th2-dependent B cell responses in the absence of CD40-CD40 ligand interactions.
Chirmule N, Tazelaar J, Wilson JM
J Immunol. 2000
PubMed ID: 10605018
CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway.
Ségui B, Andrieu-Abadie N, Adam-Klages S, Meilhac O, Kreder D, Garcia V, Bruno AP, Jaffrézou JP, Salvayre R, Krönke M, Levade T
J Biol Chem. 1999
PubMed ID: 10601289
Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation.
Tan J, Town T, Paris D, Mori T, Suo Z, Crawford F, Mattson MP, Flavell RA, Mullan M
Science. 1999
PubMed ID: 10600748
CD4+ T cell responses to CD40-deficient APCs: defects in proliferation and negative selection apply only with B cells as APCs.
Ozaki ME, Coren BA, Huynh TN, Redondo DJ, Kikutani H, Webb SR
J Immunol. 1999
PubMed ID: 10553046
Identification of a common site of provirus integration in radiation leukemia virus-induced T-cell lymphomas in mice.
Lambert J, Bergeron D, Kozak CA, Rassart E
Virology. 1999
PubMed ID: 10544143
Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: a feedback regulation of Th1 development.
Skok J, Poudrier J, Gray D
J Immunol. 1999
PubMed ID: 10510367
Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb.
Morio T, Hanissian SH, Bacharier LB, Teraoka H, Nonoyama S, Seki M, Kondo J, Nakano H, Lee SK, Geha RS, Yata J
Immunity. 1999
PubMed ID: 10514012
Disruption of CD154:CD40 blocks generation of allograft immunity without affecting APC activation.
Shepherd DM, Kerkvliet NI
J Immunol. 1999
PubMed ID: 10452982
Identification and genetic mapping of differentially expressed genes in mice differing at the If1 interferon regulatory locus.
Kozak CA, Su Y, Raj NB, Pitha PM
Mamm Genome. 1999
PubMed ID: 10441734
Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation.
Nakano H, Sakon S, Koseki H, Takemori T, Tada K, Matsumoto M, Munechika E, Sakai T, Shirasawa T, Akiba H, Kobata T, Santee SM, Ware CF, Rennert PD, Taniguchi M, Yagita H, Okumura K
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10449775
Crystallographic analysis of CD40 recognition and signaling by human TRAF2.
McWhirter SM, Pullen SS, Holton JM, Crute JJ, Kehry MR, Alber T
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10411888
Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells.
Revy P, Hivroz C, Andreu G, Graber P, Martinache C, Fischer A, Durandy A
J Immunol. 1999
PubMed ID: 10395671
A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system.
Tomura M, Yu WG, Ahn HJ, Yamashita M, Yang YF, Ono S, Hamaoka T, Kawano T, Taniguchi M, Koezuka Y, Fujiwara H
J Immunol. 1999
PubMed ID: 10384104
Cytokine-inducible CD40 gene expression in vascular smooth muscle cells is mediated by nuclear factor kappaB and signal transducer and activation of transcription-1.
Krzesz R, Wagner AH, Cattaruzza M, Hecker M
FEBS Lett. 1999
PubMed ID: 10403401
Cutting edge: contrasting roles of TNF receptor-associated factor 2 (TRAF2) and TRAF3 in CD40-activated B lymphocyte differentiation.
Hostager BS, Bishop GA
J Immunol. 1999
PubMed ID: 10352240
Functional and phenotypic analysis of thymic B cells: role in the induction of T cell negative selection.
Ferrero I, Anjuère F, Martín P, Martínez del Hoyo G, Fraga ML, Wright N, Varona R, Márquez G, Ardavín C
Eur J Immunol. 1999
PubMed ID: 10359114
NF-kappaB is activated and promotes cell death in focal cerebral ischemia.
Schneider A, Martin-Villalba A, Weih F, Vogel J, Wirth T, Schwaninger M
Nat Med. 1999
PubMed ID: 10229233
TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation.
Bachmann MF, Wong BR, Josien R, Steinman RM, Oxenius A, Choi Y
J Exp Med. 1999
PubMed ID: 10190893
Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif.
Darnay BG, Ni J, Moore PA, Aggarwal BB
J Biol Chem. 1999
PubMed ID: 10075662
Differential effects of CD40 ligand/trimer stimulation on the ability of dendritic cells to replicate and transmit HIV infection: evidence for CC-chemokine-dependent and -independent mechanisms.
McDyer JF, Dybul M, Goletz TJ, Kinter AL, Thomas EK, Berzofsky JA, Fauci AS, Seder RA
J Immunol. 1999
PubMed ID: 10092834
Bone marrow-derived cells are required for the induction of a pulmonary inflammatory response mediated by CD40 ligation.
Wiley JA, Harmsen AG
Am J Pathol. 1999
PubMed ID: 10079270
Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40.
Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J
Proc Natl Acad Sci U S A. 1999
PubMed ID: 9990007
Timing and casting for actors of thymic negative selection.
Dautigny N, Le Campion A, Lucas B
J Immunol. 1999
PubMed ID: 9973382
On costimulatory signals and T cell tolerance: relevance for transplantation immunity.
Holländer GA, Zuklys S, Förster E, Krenger W
Transplant Proc. 1999
PubMed ID: 10078224
The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification.
Caffrey JJ, Hidaka K, Matsuda M, Hirata M, Shears SB
FEBS Lett. 1999
PubMed ID: 9923613
CD20 is physically and functionally coupled to MHC class II and CD40 on human B cell lines.
Léveillé C, AL-Daccak R, Mourad W
Eur J Immunol. 1999
PubMed ID: 9933087
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
The role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivo.
Niimi M, Pearson TC, Larsen CP, Alexander DZ, Hollenbaugh D, Aruffo A, Linsley PS, Thomas E, Campbell K, Fanslow WC, Geha RS, Morris PJ, Wood KJ
J Immunol. 1998
PubMed ID: 9820506
Dendritic cells require maturation via CD40 to generate protective antitumor immunity.
Mackey MF, Gunn JR, Maliszewsky C, Kikutani H, Noelle RJ, Barth RJ
J Immunol. 1998
PubMed ID: 9725199
CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.
Pullen SS, Miller HG, Everdeen DS, Dang TT, Crute JJ, Kehry MR
Biochemistry. 1998
PubMed ID: 9718306
Reduction of atherosclerosis in mice by inhibition of CD40 signalling.
Mach F, Schönbeck U, Sukhova GK, Atkinson E, Libby P
Nature. 1998
PubMed ID: 9671306
RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.
McCarthy JV, Ni J, Dixit VM
J Biol Chem. 1998
PubMed ID: 9642260
Help for cytotoxic-T-cell responses is mediated by CD40 signalling.
Bennett SR, Carbone FR, Karamalis F, Flavell RA, Miller JF, Heath WR
Nature. 1998
PubMed ID: 9624004
Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.
Mehrabian M, Wen PZ, Fisler J, Davis RC, Lusis AJ
J Clin Invest. 1998
PubMed ID: 9616220
The role of polar interactions in the molecular recognition of CD40L with its receptor CD40.
Singh J, Garber E, Van Vlijmen H, Karpusas M, Hsu YM, Zheng Z, Naismith JH, Thomas D
Protein Sci. 1998
PubMed ID: 9605317
Cellular apoptosis susceptibility gene capts maps to mouse chromosome 2.
de Miguel M, Centanni JM, Gopalan G, Gilbert DJ, Copeland NG, Jenkins NA, Donovan PJ
Mamm Genome. 1998
PubMed ID: 9545506
cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.
Shindo M, Nakano H, Kuroyanagi H, Shirasawa T, Mihara M, Gilbert DJ, Jenkins NA, Copeland NG, Yagita H, Okumura K
Biochem Biophys Res Commun. 1998
PubMed ID: 9514916
CD40 ligand is not essential for the development of cell-mediated immunity and resistance to Mycobacterium tuberculosis.
Campos-Neto A, Ovendale P, Bement T, Koppi TA, Fanslow WC, Rossi MA, Alderson MR
J Immunol. 1998
PubMed ID: 9498737
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells.
Henn V, Slupsky JR, Gräfe M, Anagnostopoulos I, Förster R, Müller-Berghaus G, Kroczek RA
Nature. 1998
PubMed ID: 9468137
Genetic mapping of the mouse ferritin light chain gene and 11 pseudogenes on 11 mouse chromosomes.
Filie JD, Buckler CE, Kozak CA
Mamm Genome. 1998
PubMed ID: 9457670
Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).
Mizushima S, Fujita M, Ishida T, Azuma S, Kato K, Hirai M, Otsuka M, Yamamoto T, Inoue J
Gene. 1998
PubMed ID: 9511754
Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway.
Kashiwada M, Shirakata Y, Inoue JI, Nakano H, Okazaki K, Okumura K, Yamamoto T, Nagaoka H, Takemori T
J Exp Med. 1998
PubMed ID: 9432981
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases.
Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC
EMBO J. 1997
PubMed ID: 9384571
Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
Gene. 1997
PubMed ID: 9373149
Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system.
Kim JG, Armstrong RC, v Agoston D, Robinsky A, Wiese C, Nagle J, Hudson LD
J Neurosci Res. 1997
PubMed ID: 9373037
Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways.
Daikh DI, Finck BK, Linsley PS, Hollenbaugh D, Wofsy D
J Immunol. 1997
PubMed ID: 9317105
Genetic mapping of the gene encoding cysteine string protein.
Chin H, Lyu MS, Kwon OJ, Kozak CA
Mamm Genome. 1997
PubMed ID: 9257949
CD40-CD40L interactions in atherosclerosis.
Laman JD, de Smet BJ, Schoneveld A, van Meurs M
Immunol Today. 1997
PubMed ID: 9190112
CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts.
Sempowski GD, Chess PR, Phipps RP
J Immunol. 1997
PubMed ID: 9144479
Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells.
Hanissian SH, Geha RS
Immunity. 1997
PubMed ID: 9133417
Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis.
Mach F, Schönbeck U, Sukhova GK, Bourcier T, Bonnefoy JY, Pober JS, Libby P
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9050882
Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40.
Khan WN, Nilsson A, Mizoguchi E, Castigli E, Forsell J, Bhan AK, Geha R, Sideras P, Alt FW
Int Immunol. 1997
PubMed ID: 9088978
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.
Malinin NL, Boldin MP, Kovalenko AV, Wallach D
Nature. 1997
PubMed ID: 9020361
Matrix metalloproteinase-9 maps to the distal end of chromosome 2 in the mouse.
Leco KJ, Harvey MB, Hogan A, Copeland NG, Gilbert DJ, Jenkins NA, Edwards DR, Schultz GA
Dev Genet. 1997
PubMed ID: 9291580
Construction and analysis of a detailed three-dimensional model of the ligand binding domain of the human B cell receptor CD40.
Bajorath J, Aruffo A
Proteins. 1997
PubMed ID: 9037712
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig.
Schrader CE, Stavnezer J, Kikutani H, Parker DC
J Immunol. 1997
PubMed ID: 8977186
A T cell controlled molecular pathway regulating the IgH locus: CD40-mediated activation of the IgH 3' enhancer.
Grant PA, Andersson T, Neurath MF, Arulampalam V, Bauch A, Müller R, Reth M, Pettersson S
EMBO J. 1996
PubMed ID: 8978695
Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region.
Ishida T, Mizushima S, Azuma S, Kobayashi N, Tojo T, Suzuki K, Aizawa S, Watanabe T, Mosialos G, Kieff E, Yamamoto T, Inoue J
J Biol Chem. 1996
PubMed ID: 8910514
Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.
Okura T, Gong L, Kamitani T, Wada T, Okura I, Wei CF, Chang HM, Yeh ET
J Immunol. 1996
PubMed ID: 8906799
Profound reduction of mature B cell numbers, reactivities and serum Ig levels in mice which simultaneously carry the XID and CD40 deficiency genes.
Oka Y, Rolink AG, Andersson J, Kamanaka M, Uchida J, Yasui T, Kishimoto T, Kikutani H, Melchers F
Int Immunol. 1996
PubMed ID: 8943562
Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes.
Chappel MS, Hough MR, Mittel A, Takei F, Kay R, Humphries RK
J Exp Med. 1996
PubMed ID: 8920854
The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.
Rolink A, Melchers F, Andersson J
Immunity. 1996
PubMed ID: 8885865
TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling.
Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8790348
Accessory signaling by CD40 for T cell activation: induction of Th1 and Th2 cytokines and synergy with interleukin-12 for interferon-gamma production.
Peng X, Kasran A, Warmerdam PA, de Boer M, Ceuppens JL
Eur J Immunol. 1996
PubMed ID: 8766570
Genetic mapping of the human and mouse phospholipase C genes.
Lyu MS, Park DJ, Rhee SG, Kozak CA
Mamm Genome. 1996
PubMed ID: 8672127
TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor.
Nakano H, Oshima H, Chung W, Williams-Abbott L, Ware CF, Yagita H, Okumura K
J Biol Chem. 1996
PubMed ID: 8663299
Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice.
Holländer GA, Castigli E, Kulbacki R, Su M, Burakoff SJ, Gutierrez-Ramos JC, Geha RS
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8643517
CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation.
Byth KF, Conroy LA, Howlett S, Smith AJ, May J, Alexander DR, Holmes N
J Exp Med. 1996
PubMed ID: 8666928
Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection.
Soong L, Xu JC, Grewal IS, Kima P, Sun J, Longley, BJ, Ruddle NH, McMahon-Pratt D, Flavell RA
Immunity. 1996
PubMed ID: 8624816
Cleavage of membrane-bound CD40 ligand is not required for inducing B cell proliferation and differentiation.
Pietravalle F, Lecoanet-Henchoz S, Aubry JP, Elson G, Bonnefoy JY, Gauchat JF
Eur J Immunol. 1996
PubMed ID: 8605945
Recent advances in tumor necrosis factor and CD40 signaling.
Tewari M, Dixit VM
Curr Opin Genet Dev. 1996
PubMed ID: 8791485
The human CD40 gene lies within chromosome 20q deletions associated with myeloid malignancies.
Asimakopoulos FA, White NJ, Nacheva EP, Green AR
Br J Haematol. 1996
PubMed ID: 8562382
Differential requirements of CD45 for lymphocyte development and function.
Kong YY, Kishihara K, Sumichika H, Nakamura T, Kaneko M, Nomoto K
Eur J Immunol. 1995
PubMed ID: 8566034
CD40-CD40 ligand interactions stimulate B cell antigen processing.
Faassen AE, Dalke DP, Berton MT, Warren WD, Pierce SK
Eur J Immunol. 1995
PubMed ID: 8566008
TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40.
Rothe M, Sarma V, Dixit VM, Goeddel DV
Science. 1995
PubMed ID: 7544915
Analysis of gp39/CD40 interactions using molecular models and site-directed mutagenesis.
Bajorath J, Marken JS, Chalupny NJ, Spoon TL, Siadak AW, Gordon M, Noelle RJ, Hollenbaugh D, Aruffo A
Biochemistry. 1995
PubMed ID: 7543281
Inhibition of the CD40-CD40ligand pathway prevents murine membranous glomerulonephritis.
Biancone L, Andres G, Ahn H, DeMartino C, Stamenkovic I
Kidney Int. 1995
PubMed ID: 7564113
HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71).
Chirmule N, McCloskey TW, Hu R, Kalyanaraman VS, Pahwa S
J Immunol. 1995
PubMed ID: 7541827
Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTV.
Chervonsky AV, Xu J, Barlow AK, Khery M, Flavell RA, Janeway CA
Immunity. 1995
PubMed ID: 7542547
CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression.
Karmann K, Hughes CC, Schechner J, Fanslow WC, Pober JS
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7538666
Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1, Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal imprinting region of mouse chromosome 2 are not monoallelically expressed.
Williamson CM, Dutton ER, Abbott CM, Beechey CV, Ball ST, Peters J
Genet Res. 1995
PubMed ID: 7781998
Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein.
Birkeland ML, Copeland NG, Gilbert DJ, Jenkins NA, Barclay AN
Eur J Immunol. 1995
PubMed ID: 7737295
Involvement of CRAF1, a relative of TRAF, in CD40 signaling.
Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D
Science. 1995
PubMed ID: 7533327
Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis.
Mohan C, Shi Y, Laman JD, Datta SK
J Immunol. 1995
PubMed ID: 7529804
A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40.
Sato T, Irie S, Reed JC
FEBS Lett. 1995
PubMed ID: 7530216
CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.
Castigli E, Alt FW, Davidson L, Bottaro A, Mizoguchi E, Bhan AK, Geha RS
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7527552
A novel RING finger protein interacts with the cytoplasmic domain of CD40.
Hu HM, O'Rourke K, Boguski MS, Dixit VM
J Biol Chem. 1994
PubMed ID: 7527023
Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development.
Chang SC, Hoang B, Thomas JT, Vukicevic S, Luyten FP, Ryba NJ, Kozak CA, Reddi AH, Moos M
J Biol Chem. 1994
PubMed ID: 7961761
Expression of CD28 and CD40 in human myeloma cells: a comparative study with normal plasma cells.
Pellat-Deceunynck C, Bataille R, Robillard N, Harousseau JL, Rapp MJ, Juge-Morineau N, Wijdenes J, Amiot M
Blood. 1994
PubMed ID: 7522634
Monoclonal antibodies to murine CD40 define two distinct functional epitopes.
Heath AW, Wu WW, Howard MC
Eur J Immunol. 1994
PubMed ID: 7519997
Localization of the human CD40 gene to chromosome 20, bands q12-q13.2.
Lafage-Pochitaloff M, Herman P, Birg F, Galizzi JP, Simonetti J, Mannoni P, Banchereau J
Leukemia. 1994
PubMed ID: 7518550
Antibodies to murine CD40 protect normal and malignant B cells from induced growth arrest.
Santos-Argumedo L, Gordon J, Heath AW, Howard M
Cell Immunol. 1994
PubMed ID: 7517793
gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.
Foy TM, Laman JD, Ledbetter JA, Aruffo A, Claassen E, Noelle RJ
J Exp Med. 1994
PubMed ID: 7516405
Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family.
Chen Y, Fan Y, Liu J, Mestek A, Tian M, Kozak CA, Yu L
FEBS Lett. 1994
PubMed ID: 8034018
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation.
Kawabe T, Naka T, Yoshida K, Tanaka T, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T, Kikutani H
Immunity. 1994
PubMed ID: 7534202
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
PubMed ID: 8125298
B cells from CBA/N mice do not proliferate following ligation of CD40.
Hasbold J, Klaus GG
Eur J Immunol. 1994
PubMed ID: 7517360
The CD40 antigen and its ligand.
Banchereau J, Bazan F, Blanchard D, Brière F, Galizzi JP, van Kooten C, Liu YJ, Rousset F, Saeland S
Annu Rev Immunol. 1994
PubMed ID: 7516669
Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions.
Calderhead DM, Buhlmann JE, van den Eertwegh AJ, Claassen E, Noelle RJ, Fell HP
J Immunol. 1993
PubMed ID: 8228223
Chromosomal localization of the gene for human B-cell antigen CD40.
Ramesh N, Ramesh V, Gusella JF, Geha R
Somat Cell Mol Genet. 1993
PubMed ID: 7687385
Genomic structure and chromosomal mapping of the murine CD40 gene.
Grimaldi JC, Torres R, Kozak CA, Chang R, Clark EA, Howard M, Cockayne DA
J Immunol. 1992
PubMed ID: 1281194
Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells.
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J Immunol. 1992
PubMed ID: 1431091
Differential increase of an alternatively polyadenylated mRNA species of murine CD40 upon B lymphocyte activation.
Torres RM, Clark EA
J Immunol. 1992
PubMed ID: 1370315
CD40: a cytokine receptor in search of a ligand.
Clark EA
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Biochemical characteristics and partial amino acid sequence of the receptor-like human B cell and carcinoma antigen CDw40.
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Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.
Clark EA, Ledbetter JA
Proc Natl Acad Sci U S A. 1986
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A p50 surface antigen restricted to human urinary bladder carcinomas and B lymphocytes.
Paulie S, Ehlin-Henriksson B, Mellstedt H, Koho H, Ben-Aissa H, Perlmann P
Cancer Immunol Immunother. 1985
PubMed ID: 2998589

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	958	21939	171369
EnsEMBL Gene(s)	ENSG00000101017 LRG_40	ENSMUSG00000017652	ENSRNOG00000018488
Unigene	Hs.472860	Mm.271833	Rn.25180
Homologene	CD40	Cd40	Cd40
OMIM	109535	N/A	N/A
GeneCards	CD40	N/A	N/A
Beta Cell Genomics	DT.100791759 DT.451574 DT.86853137 DT.95170181	DT.101194552 DT.110729823 DT.91339881 DT.99863551 DT.99863552 DT.99863553	N/A
Reactome	P25942	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	958	21939	171369

External resources from NIDDK Consortium Interconnectivity Network Top Help

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Interactor	Interactor	Sources	Classification	Pubmed IDs
CD40	TRAF3IP2	BioGRID	empirical	12089335
CD40	KATNA1	IntAct	empirical	17353931
CD40	MAP3K8	HPRD	empirical	15670770
CD40	SLC30A7	IntAct, BioGRID	empirical	17353931
CD40	DDX3X	BioGRID	empirical	17353931
CD40	FBL	IntAct, BioGRID	empirical	17353931
CD40	NCOA6	BioGRID	empirical	10847592
CD40	ERP44	IntAct, BioGRID	empirical	17353931
CD40	XRCC6	HPRD, BioGRID	empirical	10514012
CD40	MYCBP	IntAct	empirical	17353931
CD40	BIRC2	HPRD	empirical	11562359
CD40	BIRC3	HPRD	empirical	11562359
CD40	HSPA4	HPRD, BioGRID	empirical	12356871
CD40	HSPA8	HPRD	empirical	12356871
CD40	IL4R	HPRD	empirical	12207328
CD40	JAK3	HPRD	empirical	9133417 10395671
CD40	PCMT1	IntAct	empirical	17353931
CD40	TDP2	HPRD, BioGRID	empirical	10764746
CD40	PIK3R1	HPRD	empirical	12637493
CD40	POLR2H	IntAct, BioGRID	empirical	17353931
CD40	UGGT1	IntAct, BioGRID	empirical	17353931
CD40	PSMD1	IntAct	empirical	17353931
CD40	RFC5	IntAct, BioGRID	empirical	17353931
CD40	SGK1	IntAct, BioGRID	empirical	17353931
CD40	BTK	IntAct	empirical	21441935
CD40	TRAF1	HPRD	empirical	10411888 7527023
CD40	TRAF2	HPRD, MINT, IntAct	empirical	10411888 16260598 17919601 17353931 20676093
CD40	TRAF3	HPRD, IntAct, BioGRID	empirical	7533327 7527023 10984535 7530216 16260598 9990007 9384571
CD40	TRAF5	HPRD, IntAct, BioGRID	empirical	9990007 8790348 20676093
CD40	TRAF6	HPRD, IntAct, BioGRID	empirical	10411888 10075662 16260598 12140561 20676093 8910514 9990007 9384571
CD40	TXN	IntAct, BioGRID	empirical	17353931
CD40	XRCC5	HPRD, BioGRID	empirical	10514012
CD40	SLC39A7	IntAct, BioGRID	empirical	17353931
CD40	RNF219	BioGRID	empirical	17353931
CD40	CALR	IntAct, BioGRID	empirical	17353931
CD40	NSMAF	HPRD	empirical	10601289
CD40	OGT	IntAct	empirical	17353931
CD40	CAV1	HPRD	empirical	14665433
CD40	CBL	HPRD	empirical	12637493
CD40	RIPK2	HPRD	empirical	9642260
CD40	MS4A1	HPRD	empirical	9933087
CD40	CD40LG	HPRD, Reactome	empirical	10647992 7516405 7543281 16893496
CD40	USP15	IntAct, BioGRID	empirical	17353931