Home CD86
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Regions Overlapping this Feature:
Rat: 1
Linkage Regions: 1 Available
Linkage Regions: 1 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes | Linkage and Congenic Studies |
|---|---|---|---|---|---|
| Iddm17 | Rat | chr11:19445919..87759784 | 68.31 | 594 |
(Human) GRCh37 - chr3:121774209..121839990 (65.78 kb) View in Genome Browser
(Mouse) NCBIM37 - chr16:36603955..36666167 (62.21 kb) View in Genome Browser
(Rat) RGSC3.4 - chr11:66215233..66238882 (23.65 kb) View in Genome Browser
HaemAtlas Expression Table for CD86:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for CD86:The CD86 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| CD86 | PARP1 | IntAct | empirical | 21988832 |
| CD86 | CTLA4 | HPRD, IntAct | empirical | 11279501 11021528 12606712 12071705 12582153 7513726 7694153 11162656 21982860 |
| CD86 | MARCH8 | HPRD, BioGRID | empirical | 12582153 |
| CD86 | FYN | Reactome | predicted | 9973466 8946678 |
| CD86 | LCK | Reactome | predicted | 9973466 8946678 |
| CD86 | MARCH1 | BioGRID | empirical | 21896490 |
| CD86 | UBC | BioGRID | empirical | 12582153 11756476 21896490 |
| CD86 | CD28 | HPRD | empirical | 11021528 7513726 |
| CD86 | CD80 | HPRD | empirical | 12606712 |
| CD86 | CD86 | HPRD | empirical | 11279501 |
| CD86 | ECE2 | IntAct | empirical | 21988832 |
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Type 1 Diabetes Publications: 26
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B7-1 and B7-2 differentially control peripheral homeostasis of CD4(+)CD25(+)Foxp3(+) regulatory T cells.
Zeng M, Guinet E, Nouri-Shirazi M
Transpl Immunol. 2009
PubMed ID: 18848987
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Targeting of myelin protein zero in a spontaneous autoimmune polyneuropathy.
Kim HJ, Jung CG, Jensen MA, Dukala D, Soliven B
J Immunol. 2008
PubMed ID: 19050296
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Expression of CD86 on human islet endothelial cells facilitates T cell adhesion and migration.
Lozanoska-Ochser B, Klein NJ, Huang GC, Alvarez RA, Peakman M
J Immunol. 2008
PubMed ID: 18941200
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A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes.
Phillips B, Nylander K, Harnaha J, Machen J, Lakomy R, Styche A, Gillis K, Brown L, Lafreniere D, Gallo M, Knox J, Hogeland K, Trucco M, Giannoukakis N
Diabetes. 2008
PubMed ID: 18316361
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Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation.
Perez N, Karumuthil-Melethil S, Li R, Prabhakar BS, Holterman MJ, Vasu C
J Immunol. 2008
PubMed ID: 18453575
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GAD-IgG-inducing CD4+Foxp3+Treg cells suppressing diabetes are involved in the increasing ratio of CD80+:CD86+ CELLS in NOD mice.
Wang R, Han G, Wang J, Song L, Chen G, Xu R, Zhang C, Yu M, Qian J, Shen B, Li Y
Arch Med Res. 2008
PubMed ID: 18279702
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CD86 has sustained costimulatory effects on CD8 T cells.
Thomas IJ, Petrich de Marquesini LG, Ravanan R, Smith RM, Guerder S, Flavell RA, Wraith DC, Wen L, Wong FS
J Immunol. 2007
PubMed ID: 17947667
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B7-2 regulates survival, phenotype, and function of APCs.
Yadav D, Sarvetnick N
J Immunol. 2007
PubMed ID: 17475851
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Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA
J Clin Invest. 2006
PubMed ID: 16886063
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Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice.
Bour-Jordan H, Thompson HL, Bluestone JA
J Immunol. 2005
PubMed ID: 16237054
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Altered phenotype and function of dendritic cells in children with type 1 diabetes.
Angelini F, Del Duca E, Piccinini S, Pacciani V, Rossi P, Manca Bitti ML
Clin Exp Immunol. 2005
PubMed ID: 16232222
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Dysregulated B7-1 and B7-2 expression on nonobese diabetic mouse B cells is associated with increased T cell costimulation and the development of insulitis.
Hussain S, Delovitch TL
J Immunol. 2005
PubMed ID: 15634886
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Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.
Bour-Jordan H, Salomon BL, Thompson HL, Szot GL, Bernhard MR, Bluestone JA
J Clin Invest. 2004
PubMed ID: 15467837
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B7-2 (CD86) controls the priming of autoreactive CD4 T cell response against pancreatic islets.
Yadav D, Judkowski V, Flodstrom-Tullberg M, Sterling L, Redmond WL, Sherman L, Sarvetnick N
J Immunol. 2004
PubMed ID: 15356107
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Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells.
Spatz M, Eibl N, Hink S, Wolf HM, Fischer GF, Mayr WR, Schernthaner G, Eibl MM
Cell Immunol. 2003
PubMed ID: 12742378
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CD86 gene polymorphisms: no association with Type I diabetes among Finnish subjects.
Turpeinen H, Laine AP, Nejentsev S, Sjöroos M, Ilonen J, Simell O, Veijola R, Knip M, Akerblom HK, Knip M
Diabetologia. 2002
PubMed ID: 12187923
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Role of the B7-CD28/CTLA-4 pathway in autoimmune disease.
Chang TT, Kuchroo VK, Sharpe AH
Curr Dir Autoimmun. 2002
PubMed ID: 11826754
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Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice.
Salomon B, Rhee L, Bour-Jordan H, Hsin H, Montag A, Soliven B, Arcella J, Girvin AM, Padilla J, Miller SD, Bluestone JA
J Exp Med. 2001
PubMed ID: 11535635
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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA
Immunity. 2000
PubMed ID: 10795741
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Low CD86 expression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-4 up-regulation.
Dahlén E, Hedlund G, Dawe K
J Immunol. 2000
PubMed ID: 10679081
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A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade.
Girvin AM, Dal Canto MC, Rhee L, Salomon B, Sharpe A, Bluestone JA, Miller SD
J Immunol. 2000
PubMed ID: 10605004
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CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin.
Herold KC, Vezys V, Koons A, Lenschow D, Thompson C, Bluestone JA
J Immunol. 1997
PubMed ID: 8993020
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Appearance of cells expressing CD80 and CD86 costimulatory antigens in the pancreas of nonobese diabetic mice.
Sainio-Pöllänen S, Rulli M, Pöllänen P, Simell O
Pancreas. 1996
PubMed ID: 8899799
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Islet-infiltrating t lymphocytes in insulin-dependent diabetic patients express CD80 (B7-1) and CD86 (B7-2).
Imagawa A, Hanafusa T, Itoh N, Miyagawa J, Nakajima H, Namba M, Kuwajima M, Tamura S, Kawata S, Matsuzawa Y, Harlan DM
J Autoimmun. 1996
PubMed ID: 8816976
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Pancreatic expression of B7 co-stimulatory molecules in the non-obese diabetic mouse.
Stephens LA, Kay TW
Int Immunol. 1995
PubMed ID: 8746558
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cDNA sequence of neuroendocrine protein 7B2 expressed in beta cell tumors of transgenic mice.
Mbikay M, Grant SG, Sirois F, Tadros H, Skowronski J, Lazure C, Seidah NG, Hanahan D, Chrétien M
Int J Pept Protein Res. 1989
PubMed ID: 2542174
Publications: 403
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Yeast-derived beta-(1-3),(1-6)-D-glucan induces up-regulation of CD86 on dectin-1-positive human B-lymphoma cell lines.
Harnack U, Kellermann U, Pecher G
Anticancer Res. 2011
PubMed ID: 22199280
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Toxoplasma gondii induces B7-2 expression through activation of JNK signal transduction.
Morgado P, Ong YC, Boothroyd JC, Lodoen MB
Infect Immun. 2011
PubMed ID: 21911468
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CD86 + 1057G/A polymorphism and susceptibility to osteosarcoma.
Wang W, Song H, Liu J, Song B, Cao X
DNA Cell Biol. 2011
PubMed ID: 21563968
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Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1).
Corcoran K, Jabbour M, Bhagwandin C, Deymier MJ, Theisen DL, Lybarger L
J Biol Chem. 2011
PubMed ID: 21896490
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Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction.
Kastenmuller W, Gasteiger G, Subramanian N, Sparwasser T, Busch DH, Belkaid Y, Drexler I, Germain RN
J Immunol. 2011
PubMed ID: 21849683
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Ubiquitination of CD86 is a key mechanism in regulating antigen presentation by dendritic cells.
Baravalle G, Park H, McSweeney M, Ohmura-Hoshino M, Matsuki Y, Ishido S, Shin JS
J Immunol. 2011
PubMed ID: 21849678
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Physiologic control of IDO competence in splenic dendritic cells.
Baban B, Chandler PR, Johnson BA, Huang L, Li M, Sharpe ML, Francisco LM, Sharpe AH, Blazar BR, Munn DH, Mellor AL
J Immunol. 2011
PubMed ID: 21813777
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The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo.
Yang J, Riella LV, Chock S, Liu T, Zhao X, Yuan X, Paterson AM, Watanabe T, Vanguri V, Yagita H, Azuma M, Blazar BR, Freeman GJ, Rodig SJ, Sharpe AH, Chandraker A, Sayegh MH
J Immunol. 2011
PubMed ID: 21697455
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Sustained antibody responses depend on CD28 function in bone marrow-resident plasma cells.
Rozanski CH, Arens R, Carlson LM, Nair J, Boise LH, Chanan-Khan AA, Schoenberger SP, Lee KP
J Exp Med. 2011
PubMed ID: 21690252
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CD86 +1057G>A polymorphism and susceptibility to acute kidney allograft rejection.
Krichen H, Sfar I, Bardi R, Ben Abdallah T, Jendoubi-Ayed S, Ben Aleya W, Makhlouf M, Ben Rhomdhane T, Aouadi H, Abderrahim E, Ayed K, Gorgi Y
Iran J Kidney Dis. 2011
PubMed ID: 21525579
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Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection.
Seung E, Cho JL, Sparwasser T, Medoff BD, Luster AD
J Immunol. 2011
PubMed ID: 21555535
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The relationship between CD86 and CD54 protein expression and cytotoxicity following stimulation with contact allergen in THP-1 cells.
Nukada Y, Ito Y, Miyazawa M, Sakaguchi H, Nishiyama N
J Toxicol Sci. 2011
PubMed ID: 21628959
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HLA-DR and B7-2 (CD86) monocyte expressions after major cancer surgery: profile in sepsis.
Mokart D, Textoris J, Chow-Chine L, Brun JP, Sannini A, Turrini O, Blache JL, Arnoulet C, Sainty D, Leone M
Minerva Anestesiol. 2011
PubMed ID: 21540807
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Expression and distribution of S-100, CD83, and costimulatory molecules (CD80 and CD86) in tissues of thyroid papillary carcinoma.
Xu WC, Li ZB, Chen YR, Li XT, Huang JX, Li YG, Chen SR
Cancer Invest. 2011
PubMed ID: 21469977
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B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus.
Salek-Ardakani S, Choi YS, Rafii-El-Idrissi Benhnia M, Flynn R, Arens R, Shoenberger S, Crotty S, Croft M, Salek-Ardakani S
J Immunol. 2011
PubMed ID: 21441451
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Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference.
Sang W, Zhou C, Cheng N, Li Z, Zeng L, Xu K
Immunol Lett. 2011
PubMed ID: 21277900
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Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, Baker J, Jeffery LE, Kaur S, Briggs Z, Hou TZ, Futter CE, Anderson G, Walker LS, Sansom DM
Science. 2011
PubMed ID: 21474713
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Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo.
Dolfi DV, Duttagupta PA, Boesteanu AC, Mueller YM, Oliai CH, Borowski AB, Katsikis PD
J Immunol. 2011
PubMed ID: 21389258
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Differential B7-CD28 costimulatory requirements for stable and inflationary mouse cytomegalovirus-specific memory CD8 T cell populations.
Arens R, Loewendorf A, Redeker A, Sierro S, Boon L, Klenerman P, Benedict CA, Schoenberger SP
J Immunol. 2011
PubMed ID: 21357256
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Triple expression of B7-1, B7-2 and 4-1BBL enhanced antitumor immune response against mouse H22 hepatocellular carcinoma.
Li G, Wu X, Zhang F, Li X, Sun B, Yu Y, Yin A, Deng L, Yin J, Wang X
J Cancer Res Clin Oncol. 2011
PubMed ID: 20563597
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Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells.
Kanada S, Nishiyama C, Nakano N, Suzuki R, Maeda K, Hara M, Kitamura N, Ogawa H, Okumura K
Blood. 2011
PubMed ID: 21119111
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Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation.
Bar-On L, Birnberg T, Kim KW, Jung S
Eur J Immunol. 2011
PubMed ID: 21267999
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TSLP from RSV-stimulated rat airway epithelial cells activates myeloid dendritic cells.
Qiao J, Li A, Jin X
Immunol Cell Biol. 2011
PubMed ID: 20603637
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CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.
Tze LE, Horikawa K, Domaschenz H, Howard DR, Roots CM, Rigby RJ, Way DA, Ohmura-Hoshino M, Ishido S, Andoniou CE, Degli-Esposti MA, Goodnow CC
J Exp Med. 2011
PubMed ID: 21220452
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Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells.
Li H, Matte-Martone C, Tan HS, Venkatesan S, McNiff J, Demetris AJ, Jain D, Lakkis F, Rothstein D, Shlomchik WD
J Immunol. 2011
PubMed ID: 21098219
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Differential requirements for CD80/86-CD28 costimulation in primary and memory CD4 T cell responses to vaccinia virus.
Fuse S, Tsai CY, Rommereim LM, Zhang W, Usherwood EJ
Cell Immunol. 2011
PubMed ID: 21040905
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B7-mediated costimulation of CD4 T cells constrains cytomegalovirus persistence.
Arens R, Loewendorf A, Her MJ, Schneider-Ohrum K, Shellam GR, Janssen E, Ware CF, Schoenberger SP, Benedict CA
J Virol. 2011
PubMed ID: 20980516
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Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control.
Strickland DH, Judd S, Thomas JA, Larcombe AN, Sly PD, Holt PG
Mucosal Immunol. 2011
PubMed ID: 20668438
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Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension.
Vinh A, Chen W, Blinder Y, Weiss D, Taylor WR, Goronzy JJ, Weyand CM, Harrison DG, Guzik TJ
Circulation. 2010
PubMed ID: 21126972
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TIM-3: a novel regulatory molecule of alloimmune activation.
Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N
J Immunol. 2010
PubMed ID: 20956339
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Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
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CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease.
Liu Y, Liang WB, Gao LB, Pan XM, Chen TY, Wang YY, Xue H, Zhang LS, Zhang L
Hum Immunol. 2010
PubMed ID: 20732370
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Polymorphisms affecting micro-RNA regulation and associated with the risk of dietary-related cancers: A review from the literature and new evidence for a functional role of rs17281995 (CD86) and rs1051690 (INSR), previously associated with colorectal canc
Landi D, Moreno V, Guino E, Vodicka P, Pardini B, Naccarati A, Canzian F, Barale R, Gemignani F, Landi S
Mutat Res. 2010
PubMed ID: 20971123
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House dust mite regulate the lung inflammation of asthmatic mice through TLR4 pathway in airway epithelial cells.
Hongjia L, Qingling G, Meiying L, Weixuan W, Lihong Z, Yongsheng G, Yanli L, Jinxiang W, Liang D
Cell Biochem Funct. 2010
PubMed ID: 20941750
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A multiplex MALDI-TOF MS approach facilitates genotyping of DNA from formalin-fixed paraffin-embedded tumour specimens.
Horn H, Pott C, Kalla J, Dreyling M, Rosenwald A, Ott G, Schwab M, Schaeffeler E
Pharmacogenet Genomics. 2010
PubMed ID: 20802378
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Alveolar macrophages stimulate enhanced cytokine production by pulmonary CD4+ T-lymphocytes in an exacerbation of murine chronic asthma.
Herbert C, Scott MM, Scruton KH, Keogh RP, Yuan KC, Hsu K, Siegle JS, Tedla N, Foster PS, Kumar RK
Am J Pathol. 2010
PubMed ID: 20724599
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Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
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Mycobacterium tuberculosis impairs dendritic cell response by altering CD1b, DC-SIGN and MR profile.
Balboa L, Romero MM, Yokobori N, Schierloh P, Geffner L, Basile JI, Musella RM, Abbate E, de la Barrera S, Sasiain MC, Alemán M
Immunol Cell Biol. 2010
PubMed ID: 20212510
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Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.
Fukaya T, Takagi H, Sato Y, Sato K, Eizumi K, Taya H, Shin T, Chen L, Dong C, Azuma M, Yagita H, Malissen B, Sato K
Blood. 2010
PubMed ID: 20574047
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The Association between Polymorphisms of B7 Molecules (CD80 and CD86) and Graves' Ophthalmopathy in a Taiwanese Population.
Liao WL, Chen RH, Lin HJ, Liu YH, Chen WC, Tsai Y, Wan L, Tsai FJ
Ophthalmology. 2010
PubMed ID: 20884055
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Activation of macrophages by P2X7-induced microvesicles from myeloid cells is mediated by phospholipids and is partially dependent on TLR4.
Thomas LM, Salter RD
J Immunol. 2010
PubMed ID: 20709956
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[Expression and significance of CD80/CD86 in renal tissue of lupus nephritis].
Sui MS, Zhou J, Jia XB, Mu SH, Liu XG, Ji Y, Xie RJ
Zhonghua Nei Ke Za Zhi. 2010
PubMed ID: 20979791
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Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.
Ying H, Yang L, Qiao G, Li Z, Zhang L, Yin F, Xie D, Zhang J
J Immunol. 2010
PubMed ID: 20601598
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The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus.
Grujic M, Bartholdy C, Remy M, Pinschewer DD, Christensen JP, Thomsen AR
J Immunol. 2010
PubMed ID: 20601595
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Polymorphisms in the 2q33 and 3q21 chromosome regions including T-cell coreceptor and ligand genes may influence susceptibility to pemphigus foliaceus.
Dalla-Costa R, Pincerati MR, Beltrame MH, Malheiros D, Petzl-Erler ML
Hum Immunol. 2010
PubMed ID: 20433886
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A role for dendritic cells in bleomycin-induced pulmonary fibrosis in mice?
Bantsimba-Malanda C, Marchal-Sommé J, Goven D, Freynet O, Michel L, Crestani B, Soler P
Am J Respir Crit Care Med. 2010
PubMed ID: 20395561
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CD86 +1057 G/A polymorphism and the risk of colorectal cancer.
Pan XM, Gao LB, Liang WB, Liu Y, Zhu Y, Tang M, Li YB, Zhang L
DNA Cell Biol. 2010
PubMed ID: 20380573
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Association between high-mobility group box-1 protein release and immune function of dendritic cells in thermal injury.
Zhang LT, Yao YM, Yao FH, Huang LF, Dong N, Yu Y, Sheng ZY
J Interferon Cytokine Res. 2010
PubMed ID: 20233162
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Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R
Pediatr Pulmonol. 2010
PubMed ID: 20503287
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Activated microglial cells acquire an immature dendritic cell phenotype and may terminate the immune response in an acute model of EAE.
Almolda B, González B, Castellano B
J Neuroimmunol. 2010
PubMed ID: 20451260
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Donor antigen-loaded IKK2dn gene-modified dendritic cells prolong allograft survival.
Ouyang J, Fan C, Wen D, Hou J, Du Y, Wang Y, Shi G
Scand J Immunol. 2010
PubMed ID: 20500684
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Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL, Thio CL
J Infect Dis. 2010
PubMed ID: 20331378
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New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
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Lack of B7-1 and B7-2 costimulatory molecules modulates the severity of group B Streptococcus-induced arthritis.
Puliti M, Bistoni F, Tissi L
Microbes Infect. 2010
PubMed ID: 20114085
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Absence of Association between CD86 +1057G/A Polymorphism and Coronary Artery Disease.
Ma XN, Wang X, Yan YY, Yang L, Zhang DL, Sheng X, Liu XM, Huang H, Dai J, Zhong YJ, Liao LC
DNA Cell Biol. 2010
PubMed ID: 20230296
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Artificial dental pulp exposure injury up-regulates antigen-presenting cell-related molecules in rat central nervous system.
Kaneko T, Kaneko M, Chokechanachaisakul U, Kawamura J, Kaneko R, Sunakawa M, Okiji T, Suda H
J Endod. 2010
PubMed ID: 20171363
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Pollen-induced oxidative stress influences both innate and adaptive immune responses via altering dendritic cell functions.
Csillag A, Boldogh I, Pazmandi K, Magyarics Z, Gogolak P, Sur S, Rajnavolgyi E, Bacsi A
J Immunol. 2010
PubMed ID: 20118277
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Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling.
Radziewicz H, Ibegbu CC, Hon H, Bédard N, Bruneau J, Workowski KA, Knechtle SJ, Kirk AD, Larsen CP, Shoukry NH, Grakoui A
J Immunol. 2010
PubMed ID: 20100932
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Increased gene expression of Toll-like receptors and antigen-presenting cell-related molecules in the onset of experimentally induced furcation lesions of endodontic origin in rat molars.
Chokechanachaisakul U, Kaneko T, Okiji T, Kaneko R, Kaneko M, Kawamura J, Sunakawa M, Suda H
J Endod. 2010
PubMed ID: 20113783
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PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis.
Ishizaki Y, Yukaya N, Kusuhara K, Kira R, Torisu H, Ihara K, Sakai Y, Sanefuji M, Pipo-Deveza JR, Silao CL, Sanchez BC, Lukban MB, Salonga AM, Hara T
Hum Genet. 2010
PubMed ID: 20066438
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CpG-ODN and MPLA prevent mortality in a murine model of post-hemorrhage-Staphyloccocus aureus pneumonia.
Roquilly A, Gautreau L, Segain JP, de Coppet P, Sebille V, Jacqueline C, Caillon J, Potel G, Lejus C, Josien R, Asehnoune K
PLoS One. 2010
PubMed ID: 20949109
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[Expression of co-stimulators in ulcerative colitis and its pathologic significance].
Li F, Chen AJ, Du J, Zhang Y, Gong EC, Shi XY
Zhonghua Bing Li Xue Za Zhi. 2010
PubMed ID: 20388394
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Low expression of T-cell co-stimulatory molecules in bone marrow-derived dendritic cells in a mouse model of chronic respiratory infection with Pseudomonas aeruginosa.
Mukae H, Urabe K, Yanagihara K, Ishimoto H, Sakamoto N, Ishii H, Nakayama S, Ishimatsu Y, Abe K, Shirai R, Kohno S
Tohoku J Exp Med. 2010
PubMed ID: 20046053
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Cauterization of central cornea induces recruitment of major histocompatibility complex class II+ Langerhans cells from limbal basal epithelium.
Chen W, Lin H, Dong N, Sanae T, Liu Z, Yoshitomi T
Cornea. 2010
PubMed ID: 19907296
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[Expression of co-stimulatory molecule CD86 and its inducible co-stimulator in Crohn disease and their pathologic significance].
Chen AJ, Li F, DU J, Zhang Y, Gong EC, Shi XY
Beijing Da Xue Xue Bao. 2009
PubMed ID: 20019769
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B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion.
Rau FC, Dieter J, Luo Z, Priest SO, Baumgarth N
J Immunol. 2009
PubMed ID: 19933871
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Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease.
Freeman CM, Martinez FJ, Han MK, Ames TM, Chensue SW, Todt JC, Arenberg DA, Meldrum CA, Getty C, McCloskey L, Curtis JL
Am J Respir Crit Care Med. 2009
PubMed ID: 19729666
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Dendritic cells matured by inflammation induce CD86-dependent priming of naive CD8+ T cells in the absence of their cognate peptide antigen.
Maroof A, Beattie L, Kirby A, Coles M, Kaye PM
J Immunol. 2009
PubMed ID: 19917700
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Cutting edge: requirement of MARCH-I-mediated MHC II ubiquitination for the maintenance of conventional dendritic cells.
Ohmura-Hoshino M, Matsuki Y, Mito-Yoshida M, Goto E, Aoki-Kawasumi M, Nakayama M, Ohara O, Ishido S
J Immunol. 2009
PubMed ID: 19917682
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Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells.
Carreño LJ, Pacheco R, Gutierrez MA, Jacobelli S, Kalergis AM
Immunology. 2009
PubMed ID: 20067533
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Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
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Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions.
Onodera T, Jang MH, Guo Z, Yamasaki M, Hirata T, Bai Z, Tsuji NM, Nagakubo D, Yoshie O, Sakaguchi S, Takikawa O, Miyasaka M
J Immunol. 2009
PubMed ID: 19843945
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B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function.
Ruffner MA, Kim SH, Bianco NR, Francisco LM, Sharpe AH, Robbins PD
Eur J Immunol. 2009
PubMed ID: 19757438
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Impairment of monocyte-derived dendritic cells in idiopathic pulmonary arterial hypertension.
Wang W, Yan H, Zhu W, Cui Y, Chen J, Wang X, Li S, Zhu J
J Clin Immunol. 2009
PubMed ID: 19693657
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Regulatory T cells modulate postischemic neovascularization.
Zouggari Y, Ait-Oufella H, Waeckel L, Vilar J, Loinard C, Cochain C, Récalde A, Duriez M, Levy BI, Lutgens E, Lutgens E, Mallat Z, Silvestre JS
Circulation. 2009
PubMed ID: 19770391
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Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production.
Chang M, Jin W, Sun SC
Nat Immunol. 2009
PubMed ID: 19734906
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The effect of high mobility group box-1 protein on splenic dendritic cell maturation in rats.
Zhu XM, Yao YM, Liang HP, Xu S, Dong N, Yu Y, Sheng ZY
J Interferon Cytokine Res. 2009
PubMed ID: 19642897
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TLR3-stimulated dendritic cells up-regulate B7-H1 expression and influence the magnitude of CD8 T cell responses to tumor vaccination.
Pulko V, Liu X, Krco CJ, Harris KJ, Frigola X, Kwon ED, Dong H
J Immunol. 2009
PubMed ID: 19710456
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Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions.
Kim SH, Lee JE, Kim SH, Jee YK, Kim YK, Park HS, Min KU, Park HW, The Adverse Drug Reaction Research Group in Korea
Clin Exp Allergy. 2009
PubMed ID: 19735272
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Mature CD11c(+) cells are enhanced in hypersensitivity pneumonitis.
Girard M, Israël-Assayag E, Cormier Y
Eur Respir J. 2009
PubMed ID: 19282343
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Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
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An in vitro study of the effect of size and timing of administration of titanium dioxide particles on antigen presenting activity of alveolar macrophages and peripheral blood monocytes.
Munidasa DT, Koike E, Kobayashi T
Inhal Toxicol. 2009
PubMed ID: 19653805
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Differential activation of peritoneal cells by subcutaneous treatment of rats with cryptococcal antigens.
Baronetti JL, Chiapello LS, Garro AP, Masih DT
Clin Vaccine Immunol. 2009
PubMed ID: 19494083
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PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
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Distinct roles of CD28- and CD40 ligand-mediated costimulation in the development of protective immunity and pathology during Chlamydia muridarum urogenital infection in mice.
Chen L, Cheng W, Shivshankar P, Lei L, Zhang X, Wu Y, Yeh IT, Zhong G
Infect Immun. 2009
PubMed ID: 19398542
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B-1 cell-derived monoclonal antibodies and costimulatory molecules.
Lee J, Suh J, Choi J
J Surg Res. 2009
PubMed ID: 19201420
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Cutting edge: CD28 engagement releases antigen-activated invariant NKT cells from the inhibitory effects of PD-1.
Wang J, Cheng L, Wondimu Z, Swain M, Santamaria P, Yang Y
J Immunol. 2009
PubMed ID: 19454657
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Defective expression and modulation of B7-2/CD86 on B cells in B cell chronic lymphocytic leukemia.
Dai ZS, Chen QF, Lu HZ, Xie Y
Int J Hematol. 2009
PubMed ID: 19430862
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Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke.
Thored P, Heldmann U, Gomes-Leal W, Gisler R, Darsalia V, Taneera J, Nygren JM, Jacobsen SE, Ekdahl CT, Kokaia Z, Lindvall O
Glia. 2009
PubMed ID: 19053043
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
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CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.
Kurtz J, Raval F, Vallot C, Der J, Sykes M
Blood. 2009
PubMed ID: 19179471
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CD28/B7-mediated co-stimulation is critical for early control of murine cytomegalovirus infection.
Cook CH, Chen L, Wen J, Zimmerman P, Zhang Y, Trgovcich J, Liu Y, Gao JX
Viral Immunol. 2009
PubMed ID: 19326996
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The cyclic AMP response element modulator {alpha} suppresses CD86 expression and APC function.
Ahlmann M, Varga G, Sturm K, Lippe R, Benedyk K, Viemann D, Scholzen T, Ehrchen J, Müller FU, Seidl M, Matus M, Tsokos GC, Roth J, Tenbrock K
J Immunol. 2009
PubMed ID: 19299714
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Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
Pediatr Infect Dis J. 2009
PubMed ID: 19258923
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A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy.
Louvet C, Kabre BG, Davini DW, Martinier N, Su MA, DeVoss JJ, Rosenthal WL, Anderson MS, Bour-Jordan H, Bluestone JA
J Exp Med. 2009
PubMed ID: 19221395
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B7 costimulation is critical for host control of chronic Mycobacterium tuberculosis infection.
Bhatt K, Uzelac A, Mathur S, McBride A, Potian J, Salgame P
J Immunol. 2009
PubMed ID: 19265158
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[The biological characteristics of peripheral blood CD123+ myeloid dendritic cell]
Shi J, Wang M, Wan Y, Ikeda K
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009
PubMed ID: 19257981
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Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells.
Salek-Ardakani S, Arens R, Flynn R, Sette A, Schoenberger SP, Croft M
J Immunol. 2009
PubMed ID: 19234186
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Anti-tumor immunity in a model of acute myeloid leukemia.
Cheuk AT, Wells JW, Chan L, Westwood NB, Berger SA, Yagita H, Okumura K, Farzaneh F, Mufti GJ, Guinn BA
Leuk Lymphoma. 2009
PubMed ID: 19197726
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CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance.
Friedline RH, Brown DS, Nguyen H, Kornfeld H, Lee J, Zhang Y, Appleby M, Der SD, Kang J, Chambers CA
J Exp Med. 2009
PubMed ID: 19188497
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Biological characteristics of dendritic cells derived from peripheral blood of patients with epithelial ovarian cancer.
Lan CY, Liu JH, Xia JC, Zheng LM
Chin J Cancer. 2009
PubMed ID: 19550123
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Asthma and genes encoding components of the vitamin D pathway.
Bossé Y, Lemire M, Poon AH, Daley D, He JQ, Sandford A, White JH, James AL, Musk AW, Palmer LJ, Raby BA, Weiss ST, Kozyrskyj AL, Becker A, Hudson TJ, Laprise C
Respir Res. 2009
PubMed ID: 19852851
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Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis.
Nolan A, Kobayashi H, Naveed B, Kelly A, Hoshino Y, Hoshino S, Karulf MR, Rom WN, Weiden MD, Gold JA
PLoS One. 2009
PubMed ID: 19672303
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The phagosomal proteome in interferon-gamma-activated macrophages.
Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P
Immunity. 2009
PubMed ID: 19144319
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Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer.
Wang SS, Bratti MC, Rodríguez AC, Herrero R, Burk RD, Porras C, González P, Sherman ME, Wacholder S, Lan ZE, Schiffman M, Chanock SJ, Hildesheim A
J Infect Dis. 2009
PubMed ID: 19012493
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Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells.
Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL
J Immunol. 2008
PubMed ID: 18832694
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Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation.
Kim G, Turovskaya O, Levin M, Byrne FR, Whoriskey JS, McCabe JG, Kronenberg M
J Immunol. 2008
PubMed ID: 18832683
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T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta.
Tseng SY, Waite JC, Liu M, Vardhana S, Dustin ML
J Immunol. 2008
PubMed ID: 18802089
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Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
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Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
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[A study of costimulatory molecules in allergic allergic rhinitis patients].
Zhu R, Liu G, Li W, Wang Z, Chen H, Zhang W
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008
PubMed ID: 19086656
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Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation.
McPherson M, Wei B, Turovskaya O, Fujiwara D, Brewer S, Braun J
Am J Physiol Gastrointest Liver Physiol. 2008
PubMed ID: 18617557
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Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus.
Duan B, Niu H, Xu Z, Sharpe AH, Croker BP, Sobel ES, Morel L
Lab Invest. 2008
PubMed ID: 18607347
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CD28 controls differentiation of regulatory T cells from naive CD4 T cells.
Guo F, Iclozan C, Suh WK, Anasetti C, Yu XZ
J Immunol. 2008
PubMed ID: 18684917
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Rapamycin modulates the maturation of rat bone marrow-derived dendritic cells.
Ding Y, Cheng X, Tang T, Yao R, Chen Y, Xie J, Yu X, Liao Y
J Huazhong Univ Sci Technolog Med Sci. 2008
PubMed ID: 18704298
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Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway.
Williams JA, Lumsden JM, Yu X, Feigenbaum L, Zhang J, Steinberg SM, Hodes RJ
J Immunol. 2008
PubMed ID: 18606642
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The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis.
Neubert K, Meister S, Moser K, Weisel F, Maseda D, Amann K, Wiethe C, Winkler TH, Kalden JR, Manz RA, Voll RE
Nat Med. 2008
PubMed ID: 18542049
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Increased donor CD86+CD14+ cells in the bone marrow and peripheral blood of patients with chronic graft-versus-host disease.
Arpinati M, Chirumbolo G, Marzocchi G, Baccarani M, Rondelli D
Transplantation. 2008
PubMed ID: 18580477
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NK T cells provide lipid antigen-specific cognate help for B cells.
Leadbetter EA, Brigl M, Illarionov P, Cohen N, Luteran MC, Pillai S, Besra GS, Brenner MB
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18550809
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Arming parvoviruses with CpG motifs to improve their oncosuppressive capacity.
Raykov Z, Grekova S, Leuchs B, Aprahamian M, Rommelaere J
Int J Cancer. 2008
PubMed ID: 18360875
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HLA-G-treated tolerogenic dendritic cells induce tolerogenic potential by increasing expression of B7-1 (CD80) molecules.
Smith M, Bittner JG, White S, Smith D, Horuzsko A
Transplant Proc. 2008
PubMed ID: 18589158
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Expression profiling of macrophages from subjects with atherosclerosis to identify novel susceptibility genes.
Hägg DA, Jernås M, Wiklund O, Thelle DS, Fagerberg B, Eriksson P, Hamsten A, Olsson B, Carlsson B, Carlsson LM, Svensson PA
Int J Mol Med. 2008
PubMed ID: 18506362
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Functional and phenotypic characteristics of testicular macrophages in experimental autoimmune orchitis.
Rival C, Theas MS, Suescun MO, Jacobo P, Guazzone V, van Rooijen N, Lustig L
J Pathol. 2008
PubMed ID: 18381617
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Differential control of T regulatory cell proliferation and suppressive activity by mature plasmacytoid versus conventional spleen dendritic cells.
Ouabed A, Hubert FX, Chabannes D, Gautreau L, Heslan M, Josien R
J Immunol. 2008
PubMed ID: 18424705
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Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells.
Shi Z, Rifa'i M, Lee YH, Shiku H, Isobe K, Suzuki H
Immunology. 2008
PubMed ID: 18205792
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Expression of co-stimulatory molecules B7.1 & B7.2 on macrophages infected with various strains of Mycobacterium tuberculosis & its influence on T-cell apoptosis.
Rajavelu P, Das SD
Indian J Med Res. 2008
PubMed ID: 18577795
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GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
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A novel B7-2 (CD86) splice variant with a putative negative regulatory role.
Kapsogeorgou EK, Moutsopoulos HM, Manoussakis MN
J Immunol. 2008
PubMed ID: 18322188
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Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production.
Douin-Echinard V, Laffont S, Seillet C, Delpy L, Krust A, Chambon P, Gourdy P, Arnal JF, Guéry JC
J Immunol. 2008
PubMed ID: 18322171
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Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells.
Strainic MG, Liu J, Huang D, An F, Lalli PN, Muqim N, Shapiro VS, Dubyak GR, Heeger PS, Medof ME
Immunity. 2008
PubMed ID: 18328742
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Fc{gamma} Receptors Regulate Immune Activation and Susceptibility during Mycobacterium tuberculosis Infection.
Maglione PJ, Xu J, Casadevall A, Chan J
J Immunol. 2008
PubMed ID: 18292558
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High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplant tolerance.
Tokita D, Mazariegos GV, Zahorchak AF, Chien N, Abe M, Raimondi G, Thomson AW
Transplantation. 2008
PubMed ID: 18301333
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A critical role of costimulation during intrathymic development of invariant NK T cells.
Chung Y, Nurieva R, Esashi E, Wang YH, Zhou D, Gapin L, Dong C
J Immunol. 2008
PubMed ID: 18250436
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CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis.
Nolan A, Weiden M, Kelly A, Hoshino Y, Hoshino S, Mehta N, Gold JA
Am J Respir Crit Care Med. 2008
PubMed ID: 17989345
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Control of memory CD8+ T cell differentiation by CD80/CD86-CD28 costimulation and restoration by IL-2 during the recall response.
Fuse S, Zhang W, Usherwood EJ
J Immunol. 2008
PubMed ID: 18178855
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HSP60 as a target of anti-ergotypic regulatory T cells.
Quintana FJ, Mimran A, Carmi P, Mor F, Cohen IR
PLoS ONE. 2008
PubMed ID: 19107191
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Modulation of NKT cell development by B7-CD28 interaction: an expanding horizon for costimulation.
Zheng X, Zhang H, Yin L, Wang CR, Liu Y, Zheng P
PLoS ONE. 2008
PubMed ID: 18628995
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Macrophages driven to a novel state of activation have anti-inflammatory properties in mice.
Brem-Exner BG, Sattler C, Hutchinson JA, Koehl GE, Kronenberg K, Farkas S, Inoue S, Blank C, Knechtle SJ, Schlitt HJ, Fändrich F, Geissler EK
J Immunol. 2008
PubMed ID: 18097035
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Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors.
Yamazaki S, Bonito AJ, Spisek R, Dhodapkar M, Inaba K, Steinman RM
Blood. 2007
PubMed ID: 17699744
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Heterozygous nucleotide-binding oligomerization domain-2 mutations affect monocyte maturation in Crohn's disease.
Granzotto M, Fabbro E, Maschio M, Martelossi S, Quaglia S, Tommasini A, Presani G, Ventura A
World J Gastroenterol. 2007
PubMed ID: 18069758
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Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells.
Habib-Agahi M, Phan TT, Searle PF
Int Immunol. 2007
PubMed ID: 17977894
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Low expression of antigen-presenting and costimulatory molecules by lung cells from tuberculosis patients.
Flores-Batista VC, Boechat N, Lago PM, Lazzarini LC, Pessanha LR, Almeida AS, Mafort TT, Kritski AL, Ho JL, Lapa-e-Silva JR
Braz J Med Biol Res. 2007
PubMed ID: 17713660
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Memory CD8+ T cells require CD28 costimulation.
Borowski AB, Boesteanu AC, Mueller YM, Carafides C, Topham DJ, Altman JD, Jennings SR, Katsikis PD
J Immunol. 2007
PubMed ID: 17982038
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Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro.
Dopheide JF, Sester U, Schlitt A, Horstick G, Rupprecht HJ, Münzel T, Blankenberg S
Coron Artery Dis. 2007
PubMed ID: 17925605
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Recipient cytotoxic T lymphocyte antigen-4 +49 G/G genotype is associated with reduced incidence of hepatitis B virus recurrence after liver transplantation among Chinese patients.
Jiang Z, Feng X, Zhang W, Gao F, Ling Q, Zhou L, Xie H, Chen Q, Zheng S
Liver Int. 2007
PubMed ID: 17919231
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B7 costimulation molecules expressed from the herpes simplex virus 2 genome rescue immune induction in B7-deficient mice.
Thebeau LG, Vagvala SP, Wong YM, Morrison LA
J Virol. 2007
PubMed ID: 17804511
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Expression of CD80/86 on B cells is essential for autoreactive T cell activation and the development of arthritis.
O'Neill SK, Cao Y, Hamel KM, Doodes PD, Hutas G, Finnegan A
J Immunol. 2007
PubMed ID: 17911596
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Upregulated functional expression of Toll like receptor 4 in mesenchymal stem cells induced by lipopolysaccharide.
Shi L, Wang JS, Liu XM, Hu XY, Fang Q
Chin Med J (Engl). 2007
PubMed ID: 17935670
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[Expression of Toll-like receptor 3 on peripheral blood dendritic cells in HBeAg positive patients with chronic hepatitis B]
An BY, Xie Q, Lin LY, Shen HC, Jia NN, Wang H, Guo SM, Yu H, Guo Q
Zhonghua Gan Zang Bing Za Zhi. 2007
PubMed ID: 17963596
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The role of B cells in the development of CD4 effector T cells during a polarized Th2 immune response.
Liu Q, Liu Z, Rozo CT, Hamed HA, Alem F, Urban JF, Gause WC
J Immunol. 2007
PubMed ID: 17785819
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Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B
J Infect Dis. 2007
PubMed ID: 17703412
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Role of CD80 and CD86 in host immune responses to the recombinant hemagglutinin domain of Porphyromonas gingivalis gingipain and in the adjuvanticity of cholera toxin B and monophosphoryl lipid A.
Zhang P, Lewis JP, Michalek SM, Katz J
Vaccine. 2007
PubMed ID: 17629367
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CD86 regulates IgG1 production via a CD19-dependent mechanism.
Kin NW, Sanders VM
J Immunol. 2007
PubMed ID: 17641017
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Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis reveals drug-response markers.
Grossman I, Avidan N, Singer C, Goldstaub D, Hayardeny L, Eyal E, Ben-Asher E, Paperna T, Pe'er I, Lancet D, Beckmann JS, Miller A
Pharmacogenet Genomics. 2007
PubMed ID: 17622942
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A functional CD86 polymorphism associated with asthma and related allergic disorders.
Corydon TJ, Haagerup A, Jensen TG, Binderup HG, Petersen MS, Kaltoft K, Vestbo J, Kruse TA, Børglum AD
J Med Genet. 2007
PubMed ID: 17513529
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Blockade of the 4-1BB (CD137)/4-1BBL and/or CD28/CD80/CD86 costimulatory pathways promotes corneal allograft survival in mice.
Asai T, Choi BK, Kwon PM, Kim WY, Kim JD, Vinay DS, Gebhardt BM, Kwon BS
Immunology. 2007
PubMed ID: 17376197
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[Expression of co-stimulatory molecules and role of interleukin 18 in peripheral lymphocytes of patients with idiopathic thrombocytopenic purpura]
Pan JL, Guan XR, Ma XH, He X
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007
PubMed ID: 17605869
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The CD28/CTLA-4-B7 signaling pathway is involved in both allergic sensitization and tolerance induction to orally administered peanut proteins.
van Wijk F, Nierkens S, de Jong W, Wehrens EJ, Boon L, van Kooten P, Knippels LM, Pieters R
J Immunol. 2007
PubMed ID: 17513738
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Paradoxical effect of reduced costimulation in T cell-mediated colitis.
Kim G, Levin M, Schoenberger SP, Sharpe A, Kronenberg M
J Immunol. 2007
PubMed ID: 17442938
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Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease.
Chikuma S, Bluestone JA
Eur J Immunol. 2007
PubMed ID: 17429849
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Expression of the costimulatory molecule CD86, but not CD80, in keratinocytes of normal cervical epithelium and human papillomavirus-16 positive low squamous intraepithelial lesions.
Ortiz-Sánchez E, Chávez-Olmos P, Piña-Sánchez P, Salcedo M, Garrido E
Int J Gynecol Cancer. 2007
PubMed ID: 17386046
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Anti-B7-1/B7-2 antibody elicits innate-effector responses in macrophages through NF-kappaB-dependent pathway.
Khan N, Ghousunnissa S, Jegadeeswaran SM, Thiagarajan D, Hasnain SE, Mukhopadhyay S
Int Immunol. 2007
PubMed ID: 17314080
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A two-pronged mechanism for HIV-1 Nef-mediated endocytosis of immune costimulatory molecules CD80 and CD86.
Chaudhry A, Das SR, Jameel S, George A, Bal V, Mayor S, Rath S
Cell Host Microbe. 2007
PubMed ID: 18005680
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Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN.
Hervas-Stubbs S, Rueda P, Lopez L, Leclerc C
J Immunol. 2007
PubMed ID: 17277142
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Monovalent antibody scFv fragments selected to modulate T-cell activation by inhibition of CD86-CD28 interaction.
Kolly R, Thiel MA, Herrmann T, Plückthun A
Protein Eng Des Sel. 2007
PubMed ID: 17289805
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B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells.
May KF, Chang X, Zhang H, Lute KD, Zhou P, Kocak E, Zheng P, Liu Y
J Immunol. 2007
PubMed ID: 17237403
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Chondrogenic differentiation alters the immunosuppressive property of bone marrow-derived mesenchymal stem cells, and the effect is partially due to the upregulated expression of B7 molecules.
Chen X, McClurg A, Zhou GQ, McCaigue M, Armstrong MA, Li G
Stem Cells. 2007
PubMed ID: 17068184
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Differential contributions of B7-1 and B7-2 to the development of murine experimental allergic conjunctivitis.
Sumi T, Fukushima A, Fukuda K, Kumagai N, Nishida T, Yagita H, Ueno H
Immunol Lett. 2007
PubMed ID: 17109973
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Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma.
Chang CS, Chang JH, Hsu NC, Lin HY, Chung CY
BMC Cancer. 2007
PubMed ID: 17524139
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The net effect of costimulatory blockers is dependent on the subset and activation status of the autoreactive T cells.
Zhang P, Sun D, Ke Y, Kaplan HJ, Shao H
J Immunol. 2007
PubMed ID: 17182586
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Differential requirement for CD28 and CD80/86 pathways of costimulation in the long-term control of murine gammaherpesvirus-68.
Lyon AB, Sarawar SR
Virology. 2006
PubMed ID: 16934307
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B7+ iris pigment epithelial cells convert T cells into CTLA-4+, B7-expressing CD8+ regulatory T cells.
Sugita S, Keino H, Futagami Y, Takase H, Mochizuki M, Stein-Streilein J, Streilein JW
Invest Ophthalmol Vis Sci. 2006
PubMed ID: 17122127
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Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors.
Short JJ, Vasu C, Holterman MJ, Curiel DT, Pereboev A
Virus Res. 2006
PubMed ID: 16920215
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An essential role for dendritic cells in human and experimental allergic rhinitis.
KleinJan A, Willart M, van Rijt LS, Braunstahl GJ, Leman K, Jung S, Hoogsteden HC, Lambrecht BN
J Allergy Clin Immunol. 2006
PubMed ID: 17088138
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The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS.
Quaranta MG, Mattioli B, Giordani L, Viora M
FASEB J. 2006
PubMed ID: 17077296
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5HT4 agonists inhibit interferon-gamma-induced MHC class II and B7 costimulatory molecules expression on cultured astrocytes.
Zeinstra EM, Wilczak N, Wilschut JC, Glazenburg L, Chesik D, Kroese FG, De Keyser J
J Neuroimmunol. 2006
PubMed ID: 16839612
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CD80 and CD86 control antiviral CD8+ T-cell function and immune surveillance of murine gammaherpesvirus 68.
Fuse S, Obar JJ, Bellfy S, Leung EK, Zhang W, Usherwood EJ
J Virol. 2006
PubMed ID: 16940527
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Intraperitoneal Echinococcus multilocularis infection in C57BL/6 mice affects CD40 and B7 costimulator expression on peritoneal macrophages and impairs peritoneal T cell activation.
Mejri N, Gottstein B
Parasite Immunol. 2006
PubMed ID: 16879309
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Streptococcus pneumoniae Infection aggravates experimental autoimmune encephalomyelitis via Toll-like receptor 2.
Herrmann I, Kellert M, Schmidt H, Mildner A, Hanisch UK, Brück W, Prinz M, Nau R
Infect Immun. 2006
PubMed ID: 16861672
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Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation.
Watanabe R, Harada Y, Takeda K, Takahashi J, Ohnuki K, Ogawa S, Ohgai D, Kaibara N, Koiwai O, Tanabe K, Toma H, Sugamura K, Abe R
J Immunol. 2006
PubMed ID: 16818765
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[Clone and expression of murine BTLA extracellular domain gene and its effect on the expression of B7 on dendritic cells]
Xu JF, Zhao K, Huang BJ, Xiong P, Fang M, Shen GX, Gong FL
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2006
PubMed ID: 16805995
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In vivo role of dendritic cells in a murine model of pulmonary cryptococcosis.
Wozniak KL, Vyas JM, Levitz SM
Infect Immun. 2006
PubMed ID: 16790753
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Purified neonatal plasmacytoid dendritic cells overcome intrinsic maturation defect with TLR agonist stimulation.
Gold MC, Donnelly E, Cook MS, Leclair CM, Lewinsohn DA
Pediatr Res. 2006
PubMed ID: 16690948
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T-cell tolerance or function is determined by combinatorial costimulatory signals.
Nurieva R, Thomas S, Nguyen T, Martin-Orozco N, Wang Y, Kaja MK, Yu XZ, Dong C
EMBO J. 2006
PubMed ID: 16724117
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A polymorphism in the promoter region of the CD86 (B7.2) gene is associated with systemic sclerosis.
Abdallah AM, Renzoni EA, Anevlavis S, Lagan AL, Munkonge FM, Fonseca C, Black CM, Briggs D, Wells AU, Marshall SE, McHugh N, du Bois RM, Welsh KI
Int J Immunogenet. 2006
PubMed ID: 16712644
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CD86 stimulation on a B cell activates the phosphatidylinositol 3-kinase/Akt and phospholipase C gamma 2/protein kinase C alpha beta signaling pathways.
Kin NW, Sanders VM
J Immunol. 2006
PubMed ID: 16709832
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Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells.
Chen W, Wang J, Shao C, Liu S, Yu Y, Wang Q, Cao X
Eur J Immunol. 2006
PubMed ID: 16708399
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mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging.
Frank MG, Barrientos RM, Biedenkapp JC, Rudy JW, Watkins LR, Maier SF
Neurobiol Aging. 2006
PubMed ID: 15890435
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The DNA sequence, annotation and analysis of human chromosome 3.
Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA
Nature. 2006
PubMed ID: 16641997
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BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
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Peritoneal macrophages suppress T-cell activation by amino acid catabolism.
Matlack R, Yeh K, Rosini L, Gonzalez D, Taylor J, Silberman D, Pennello A, Riggs J
Immunology. 2006
PubMed ID: 16476058
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Induction of oral tolerization in CD86 deficient mice: a role for CD86 and B cells in the up-regulation of TGF-beta.
Gonnella PA, Chen YH, Waldner H, Weiner HL
J Autoimmun. 2006
PubMed ID: 16439314
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Natural regulatory T cells control the development of atherosclerosis in mice.
Ait-Oufella H, Salomon BL, Potteaux S, Robertson AK, Gourdy P, Zoll J, Merval R, Esposito B, Cohen JL, Fisson S, Flavell RA, Hansson GK, Klatzmann D, Tedgui A, Mallat Z
Nat Med. 2006
PubMed ID: 16462800
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Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism.
Montagnoli C, Fallarino F, Gaziano R, Bozza S, Bellocchio S, Zelante T, Kurup WP, Pitzurra L, Puccetti P, Romani L
J Immunol. 2006
PubMed ID: 16424201
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Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
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Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells.
Kovacs B, Parry RV, Ma Z, Fan E, Shivers DK, Freiberg BA, Thomas AK, Rutherford R, Rumbley CA, Riley JL, Finkel TH
J Immunol. 2005
PubMed ID: 16339520
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Bone marrow-derived dendritic cells reverse the anergic state of CD4+CD25+ T cells without reversing their suppressive function.
Brinster C, Shevach EM
J Immunol. 2005
PubMed ID: 16301639
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LIGHT regulates CD86 expression on dendritic cells through NF-kappaB, but not JNK/AP-1 signal transduction pathway.
Zou GM, Hu WY
J Cell Physiol. 2005
PubMed ID: 15895390
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Francisella tularensis induces aberrant activation of pulmonary dendritic cells.
Bosio CM, Dow SW
J Immunol. 2005
PubMed ID: 16272336
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Functional analysis of HIV type 1 Nef reveals a role for PAK2 as a regulator of cell phenotype and function in the murine dendritic cell line, DC2.4.
Mann J, Patrick CN, Cragg MS, Honeychurch J, Mann DA, Harris M
J Immunol. 2005
PubMed ID: 16272310
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Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells.
Krupnick AS, Gelman AE, Barchet W, Richardson S, Kreisel FH, Turka LA, Colonna M, Patterson GA, Kreisel D
J Immunol. 2005
PubMed ID: 16272276
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CD80/CD86 costimulation regulates acute vascular rejection.
Hosiawa KA, Wang H, DeVries ME, Garcia B, Liu W, Zhou D, Akram A, Jiang J, Sun H, Cameron MJ, Zhong R, Kelvin DJ
J Immunol. 2005
PubMed ID: 16237117
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.
Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C
Nat Immunol. 2005
PubMed ID: 16200068
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Different cell surface oligomeric states of B7-1 and B7-2: implications for signaling.
Bhatia S, Edidin M, Almo SC, Nathenson SG
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16221763
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Evaluation of CD86 gene polymorphism at +1057 position in liver transplant recipients.
Marín LA, Moya-Quiles MR, Miras M, Muro M, Minguela A, Bermejo J, Ramírez P, García-Alonso AM, Parrilla P, Alvarez-López MR
Transpl Immunol. 2005
PubMed ID: 16223675
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The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs.
Chaudhry A, Das SR, Hussain A, Mayor S, George A, Bal V, Jameel S, Rath S
J Immunol. 2005
PubMed ID: 16177101
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Differential requirement for CD28/CTLA-4-CD80/CD86 interactions in drug-induced type 1 and type 2 immune responses to trinitrophenyl-ovalbumin.
Nierkens S, Aalbers M, Bol M, Bleumink R, van Kooten P, Boon L, Pieters R
J Immunol. 2005
PubMed ID: 16148116
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells.
Feuillet V, Lucas B, Di Santo JP, Bismuth G, Trautmann A
Eur J Immunol. 2005
PubMed ID: 16078277
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Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia.
Tamura H, Dan K, Tamada K, Nakamura K, Shioi Y, Hyodo H, Wang SD, Dong H, Chen L, Ogata K
Clin Cancer Res. 2005
PubMed ID: 16115907
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Parenchymal expression of CD86/B7.2 contributes to hepatitis C virus-related liver injury.
Sun J, Tumurbaatar B, Jia J, Diao H, Bodola F, Lemon SM, Tang W, Bowen DG, McCaughan GW, Bertolino P, Chan TS
J Virol. 2005
PubMed ID: 16051865
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CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms.
Odobasic D, Kitching AR, Tipping PG, Holdsworth SR
Kidney Int. 2005
PubMed ID: 16014035
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Hierarchical regulation of CTLA-4 dimer-based lattice formation and its biological relevance for T cell inactivation.
Darlington PJ, Kirchhof MG, Criado G, Sondhi J, Madrenas J
J Immunol. 2005
PubMed ID: 16002699
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Mechanisms of gene therapy for tolerance: B7 signaling is required for peptide-IgG gene-transferred tolerance induction.
Litzinger MT, Su Y, Lei TC, Soukhareva N, Scott DW
J Immunol. 2005
PubMed ID: 16002674
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ICOS contributes to T cell expansion in CTLA-4 deficient mice.
van Berkel ME, Schrijver EH, Hofhuis FM, Sharpe AH, Coyle AJ, Broeren CP, Tesselaar K, Oosterwegel MA
J Immunol. 2005
PubMed ID: 15972646
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B7-independent inhibition of T cells by CTLA-4.
Chikuma S, Abbas AK, Bluestone JA
J Immunol. 2005
PubMed ID: 15972645
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Human immunodeficiency virus type 1 Vpr impairs dendritic cell maturation and T-cell activation: implications for viral immune escape.
Majumder B, Janket ML, Schafer EA, Schaubert K, Huang XL, Kan-Mitchell J, Rinaldo CR, Ayyavoo V
J Virol. 2005
PubMed ID: 15956545
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Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis.
Odobasic D, Kitching AR, Semple TJ, Timoshanko JR, Tipping PG, Holdsworth SR
J Am Soc Nephrol. 2005
PubMed ID: 15944341
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ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming.
Segura E, Nicco C, Lombard B, Véron P, Raposo G, Batteux F, Amigorena S, Théry C
Blood. 2005
PubMed ID: 15790784
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CTLA4-CD80/CD86 interactions on primary mouse CD4+ T cells integrate signal-strength information to modulate activation with Concanavalin A.
Mukherjee S, Ahmed A, Nandi D
J Leukoc Biol. 2005
PubMed ID: 15788440
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Abortive versus productive viral infection of dendritic cells with a paramyxovirus results in differential upregulation of select costimulatory molecules.
Pejawar SS, Parks GD, Alexander-Miller MA
J Virol. 2005
PubMed ID: 15919909
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Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo.
Ito T, Ueno T, Clarkson MR, Yuan X, Jurewicz MM, Yagita H, Azuma M, Sharpe AH, Auchincloss H, Sayegh MH, Najafian N
J Immunol. 2005
PubMed ID: 15905503
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Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis.
Handa T, Nagai S, Ito I, Tabuena R, Shigematsu M, Hamada K, Kitaichi M, Izumi T, Aoyama T, Toguchida J, Mishima M
Respiration. 2005
PubMed ID: 15942292
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An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice.
Loser K, Scherer A, Krummen MB, Varga G, Higuchi T, Schwarz T, Sharpe AH, Grabbe S, Bluestone JA, Beissert S
J Immunol. 2005
PubMed ID: 15843526
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Critical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviation.
Tsukahara R, Takeuchi M, Akiba H, Kezuka T, Takeda K, Usui Y, Usui M, Yagita H, Okumura K
Int Immunol. 2005
PubMed ID: 15778288
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Regulatory T cell lineage specification by the forkhead transcription factor foxp3.
Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY
Immunity. 2005
PubMed ID: 15780990
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Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ.
Anderson BE, McNiff JM, Jain D, Blazar BR, Shlomchik WD, Shlomchik MJ
Blood. 2005
PubMed ID: 15522961
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A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection.
Vacchio MS, Williams JA, Hodes RJ
Eur J Immunol. 2005
PubMed ID: 15657954
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Differential subcellular localization of CD86 in human PBMC-derived macrophages and DCs, and ultrastructural characterization by immuno-electron microscopy.
Smyth CM, Logan G, Boadle R, Rowe PB, Smythe JA, Alexander IE
Int Immunol. 2005
PubMed ID: 15623548
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HIV-1 Vpr inhibits the maturation and activation of macrophages and dendritic cells in vitro.
Muthumani K, Hwang DS, Choo AY, Mayilvahanan S, Dayes NS, Thieu KP, Weiner DB
Int Immunol. 2005
PubMed ID: 15611322
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Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus.
Liang S, Alard P, Zhao Y, Parnell S, Clark SL, Kosiewicz MM
J Exp Med. 2005
PubMed ID: 15630140
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CD80, but not CD86, express on cultured murine keratinocyte stem cells.
Lei J, Cheng J, Li Y, Li S, Zhang L
Transplant Proc. 2005
PubMed ID: 15808622
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A neurogenomics approach to gene expression analysis in the developing brain.
Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T
Brain Res Mol Brain Res. 2004
PubMed ID: 15582152
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Regulated recruitment of MHC class II and costimulatory molecules to lipid rafts in dendritic cells.
Meyer zum Bueschenfelde CO, Unternaehrer J, Mellman I, Bottomly K
J Immunol. 2004
PubMed ID: 15528348
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The role of costimulatory molecules CD80 and CD86 and IFNgamma in the pathogenesis of ulcerative colitis.
Scarpa M, Behboo R, Angriman I, Termini B, Barollo M, Ruffolo C, Polese L, D'Incà R, Sturniolo GC, D'Amico DF
Dig Dis Sci. 2004
PubMed ID: 15628695
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Up-regulation of CD80-CD86 and IgA on mouse peritoneal B-1 cells by porin of Shigella dysenteriae is Toll-like receptors 2 and 6 dependent.
Ray A, Karmakar P, Biswas T
Mol Immunol. 2004
PubMed ID: 15482852
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Role of B7 in T cell tolerance.
Lohr J, Knoechel B, Kahn EC, Abbas AK
J Immunol. 2004
PubMed ID: 15470046
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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Role of B7 costimulatory molecules in mediating systemic and mucosal antibody responses to attenuated Salmonella enterica serovar Typhimurium and its cloned antigen.
Garcia CA, Martin M, Michalek SM
Infect Immun. 2004
PubMed ID: 15385483
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A role for CD28 in lymphopenia-induced proliferation of CD4 T cells.
Hagen KA, Moses CT, Drasler EF, Podetz-Pedersen KM, Jameson SC, Khoruts A
J Immunol. 2004
PubMed ID: 15356139
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CD24 controls expansion and persistence of autoreactive T cells in the central nervous system during experimental autoimmune encephalomyelitis.
Bai XF, Li O, Zhou Q, Zhang H, Joshi PS, Zheng X, Liu Y, Wang Y, Zheng P, Liu Y
J Exp Med. 2004
PubMed ID: 15314074
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B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8- T cells in the thymus.
Zheng X, Gao JX, Chang X, Wang Y, Liu Y, Wen J, Zhang H, Zhang J, Liu Y, Zheng P
J Immunol. 2004
PubMed ID: 15294937
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Model for the interaction of gammaherpesvirus 68 RING-CH finger protein mK3 with major histocompatibility complex class I and the peptide-loading complex.
Wang X, Lybarger L, Connors R, Harris MR, Hansen TH
J Virol. 2004
PubMed ID: 15280476
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CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development.
McKee AS, Pearce EJ
J Immunol. 2004
PubMed ID: 15240714
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The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation.
Fujii S, Liu K, Smith C, Bonito AJ, Steinman RM
J Exp Med. 2004
PubMed ID: 15197224
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Insertion of host-derived costimulatory molecules CD80 (B7.1) and CD86 (B7.2) into human immunodeficiency virus type 1 affects the virus life cycle.
Giguère JF, Bounou S, Paquette JS, Madrenas J, Tremblay MJ
J Virol. 2004
PubMed ID: 15163715
-
Down-regulation of HLA class II and costimulatory CD86/B7-2 on circulating monocytes from melanoma patients.
Ugurel S, Uhlig D, Pföhler C, Tilgen W, Schadendorf D, Reinhold U
Cancer Immunol Immunother. 2004
PubMed ID: 14727087
-
IL-4 confers NK stimulatory capacity to murine dendritic cells: a signaling pathway involving KARAP/DAP12-triggering receptor expressed on myeloid cell 2 molecules.
Terme M, Tomasello E, Maruyama K, Crépineau F, Chaput N, Flament C, Marolleau JP, Angevin E, Wagner EF, Salomon B, Lemonnier FA, Wakasugi H, Colonna M, Vivier E, Zitvogel L
J Immunol. 2004
PubMed ID: 15128777
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Dominance of CD86, transforming growth factor- beta 1, and interleukin-10 in Mycobacterium tuberculosis secretory antigen-activated dendritic cells regulates T helper 1 responses to mycobacterial antigens.
Balkhi MY, Sinha A, Natarajan K
J Infect Dis. 2004
PubMed ID: 15116295
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Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors.
Short JJ, Pereboev AV, Kawakami Y, Vasu C, Holterman MJ, Curiel DT
Virology. 2004
PubMed ID: 15110532
-
Cross-regulation of CD86 by CD80 differentially regulates T helper responses from Mycobacterium tuberculosis secretory antigen-activated dendritic cell subsets.
Balkhi MY, Latchumanan VK, Singh B, Sharma P, Natarajan K
J Leukoc Biol. 2004
PubMed ID: 14966193
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B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice.
Buono C, Pang H, Uchida Y, Libby P, Sharpe AH, Lichtman AH
Circulation. 2004
PubMed ID: 15096453
-
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
-
CTLA-4 gene polymorphism in promoter and exon-1 regions is not associated with Chinese patients with rheumatoid arthritis.
Liu MF, Wang CR, Chen PC, Lin TL
Clin Rheumatol. 2004
PubMed ID: 15045639
-
CTLA-4+CD8+ T cells that encounter B7-2+ iris pigment epithelial cells express their own B7-2 to achieve global suppression of T cell activation.
Sugita S, Ng TF, Schwartzkopff J, Streilein JW
J Immunol. 2004
PubMed ID: 15034031
-
Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells.
Munn DH, Sharma MD, Mellor AL
J Immunol. 2004
PubMed ID: 15034022
-
CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells.
Zheng Y, Manzotti CN, Liu M, Burke F, Mead KI, Sansom DM
J Immunol. 2004
PubMed ID: 14978077
-
Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients.
Teutsch SM, Booth DR, Bennetts BH, Heard RN, Stewart GJ
J Neuroimmunol. 2004
PubMed ID: 14975605
-
Clinical significance of costimulatory molecules CD80/CD86 expression in IgA nephropathy.
Wu Q, Jinde K, Endoh M, Sakai H
Kidney Int. 2004
PubMed ID: 14871408
-
Schistosoma mansoni PIII antigen modulates in vitro granuloma formation by regulating CD28, CTLA-4, and CD86 expression in humans.
Zouain CS, Falcão PL, Goes TS, Leite MF, Goes AM
Immunol Lett. 2004
PubMed ID: 15019278
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[Expression of CD 86 on monocyte and B cell surface, the level of T(H)-derived cytokine and their correlation in children with asthma]
Zhu XP, Yang XQ, Fu Z, Yu HG, Lian GL, Li X
Zhonghua Er Ke Za Zhi. 2004
PubMed ID: 15059478
-
Role of B7 costimulatory molecules in immune responses and T-helper cell differentiation in response to recombinant HagB from Porphyromonas gingivalis.
Zhang P, Martin M, Yang QB, Michalek SM, Katz J
Infect Immun. 2004
PubMed ID: 14742503
-
The role of B7 ligands (CD80 and CD86) in CD152-mediated allograft tolerance: a crosscheck hypothesis.
Tsai MK, Ho HN, Chien HF, Ou-Yang P, Lee CJ, Lee PH
Transplantation. 2004
PubMed ID: 14724434
-
Presence of spinal B7.2 (CD86) but not B7.1 (CD80) co-stimulatory molecules following peripheral nerve injury: role of nondestructive immunity in neuropathic pain.
Rutkowski MD, Lambert F, Raghavendra V, DeLeo JA
J Neuroimmunol. 2004
PubMed ID: 14698851
-
B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections].
Taylor PA, Lees CJ, Fournier S, Allison JP, Sharpe AH, Blazar BR
J Immunol. 2004
PubMed ID: 14688306
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
-
Role of nod2 in the response of macrophages to toll-like receptor agonists.
Pauleau AL, Murray PJ
Mol Cell Biol. 2003
PubMed ID: 14560001
-
Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake.
Yada A, Ebihara S, Matsumura K, Endo S, Maeda T, Nakamura A, Akiyama K, Aiba S, Takai T
Cell Immunol. 2003
PubMed ID: 14643301
-
Dendritic cell uptake of human apoptotic and necrotic neutrophils inhibits CD40, CD80, and CD86 expression and reduces allogeneic T cell responses: relevance to systemic vasculitis.
Clayton AR, Prue RL, Harper L, Drayson MT, Savage CO
Arthritis Rheum. 2003
PubMed ID: 12905492
-
Augmentation of B7 expression by herpes simplex virus antigen.
Singh R, Kumar A, Diaz-Mitoma F
Hum Immunol. 2003
PubMed ID: 12878356
-
Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor.
Shin T, Kennedy G, Gorski K, Tsuchiya H, Koseki H, Azuma M, Yagita H, Chen L, Powell J, Pardoll D, Housseau F
J Exp Med. 2003
PubMed ID: 12847135
-
Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4.
Sugita S, Streilein JW
J Exp Med. 2003
PubMed ID: 12835481
-
Cross-species costimulation: relative contributions of CD80, CD86, and CD40.
Rogers NJ, Jackson IM, Jordan WJ, Hawadle MA, Dorling A, Lechler RI
Transplantation. 2003
PubMed ID: 12829914
-
A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
Buhlmann JE, Elkin SK, Sharpe AH
J Immunol. 2003
PubMed ID: 12759417
-
Selective regulation of mature IgG1 transcription by CD86 and beta 2-adrenergic receptor stimulation.
Podojil JR, Sanders VM
J Immunol. 2003
PubMed ID: 12734361
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c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity.
Goto E, Ishido S, Sato Y, Ohgimoto S, Ohgimoto K, Nagano-Fujii M, Hotta H
J Biol Chem. 2003
PubMed ID: 12582153
-
B7-1 costimulatory molecule is critical for the development of experimental autoimmune myasthenia gravis.
Poussin MA, Tüzün E, Goluszko E, Scott BG, Yang H, Franco JU, Christadoss P
J Immunol. 2003
PubMed ID: 12682276
-
The role of PI3K in immune cells.
Koyasu S
Nat Immunol. 2003
PubMed ID: 12660731
-
Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling.
Zhang X, Schwartz JC, Almo SC, Nathenson SG
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12606712
-
Upregulation of B7 molecules (CD80 and CD86) and exacerbated eosinophilic pulmonary inflammatory response in mice lacking the IFN-beta gene.
Matheu V, Treschow A, Navikas V, Issazadeh-Navikas S
J Allergy Clin Immunol. 2003
PubMed ID: 12642836
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Monocyte-derived IL12, CD86 (B7-2) and CD40L expression in relapsing and progressive multiple sclerosis.
Filion LG, Matusevicius D, Graziani-Bowering GM, Kumar A, Freedman MS
Clin Immunol. 2003
PubMed ID: 12672403
-
Differential requirements for expression of CD80/86 and CD40 on B cells for T-dependent antibody responses in vivo.
Lumsden JM, Williams JA, Hodes RJ
J Immunol. 2003
PubMed ID: 12517941
-
CD80 and CD86 expression on LPS-stimulated monocytes and the effect of CD80 and CD86 blockade on IL-4 and IFN-gamma production in nonatopic bronchial asthma.
Rutkowski R, Moniuszko T, Stasiak-Barmuta A, Kosztyła-Hojna B, Alifier M, Rutkowski K, Tatarczuk-Krawiel A
Arch Immunol Ther Exp (Warsz). 2003
PubMed ID: 14692664
-
Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody.
Yokota A, Oikawa A, Matsuda C, Shinohara N, Eshima K
Microbiol Immunol. 2003
PubMed ID: 12801066
-
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
-
Opsonization of apoptotic cells by autologous iC3b facilitates clearance by immature dendritic cells, down-regulates DR and CD86, and up-regulates CC chemokine receptor 7.
Verbovetski I, Bychkov H, Trahtemberg U, Shapira I, Hareuveni M, Ben-Tal O, Kutikov I, Gill O, Mevorach D
J Exp Med. 2002
PubMed ID: 12486098
-
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
-
Blockade of CD86 in BALB/c mice infected with Leishmania major does not prevent the expansion of low avidity T cells.
Moro M, Filippi C, Gallard A, Malherbe L, Foucras G, Akiba H, Yagita H, Guéry JC, Glaichenhaus N
Eur J Immunol. 2002
PubMed ID: 12516542
-
[The identical effects of B7-1 and B7-2 on regulation of human IL-2 gene transcription factors NF-kappa B and AP-1]
Ke XY, Gribben J, Wang J, Wang DB
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2002
PubMed ID: 12513711
-
B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans.
Montagnoli C, Bacci A, Bozza S, Gaziano R, Mosci P, Sharpe AH, Romani L
J Immunol. 2002
PubMed ID: 12444136
-
Expression of B7 molecules in the eye during experimental autoimmune anterior uveitis (EAAU).
Shao H, Sun D, Sun SL, Cruze JM, Bora N, Kaplan HJ
Curr Eye Res. 2002
PubMed ID: 12658546
-
Role of CD80, CD86, and CTLA4 on mouse CD4(+) T lymphocytes in enhancing cell-cycle progression and survival after activation with PMA and ionomycin.
Mukherjee S, Maiti PK, Nandi D
J Leukoc Biol. 2002
PubMed ID: 12429713
-
Cutting edge: a crucial role for B7-CD28 in transmitting T help from APC to CTL.
Prilliman KR, Lemmens EE, Palioungas G, Wolfe TG, Allison JP, Sharpe AH, Schoenberger SP
J Immunol. 2002
PubMed ID: 12370335
-
Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice.
Schneider H, Mandelbrot DA, Greenwald RJ, Ng F, Lechler R, Sharpe AH, Rudd CE
J Immunol. 2002
PubMed ID: 12244135
-
CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis.
Mencacci A, Montagnoli C, Bacci A, Cenci E, Pitzurra L, Spreca A, Kopf M, Sharpe AH, Romani L
J Immunol. 2002
PubMed ID: 12218136
-
Cutting edge: the relative distribution of T cells responding to chemically dominant or minor epitopes of lysozyme is not affected by CD40-CD40 ligand and B7-CD28-CTLA-4 costimulatory pathways.
DiPaolo RJ, Unanue ER
J Immunol. 2002
PubMed ID: 12218093
-
Intense expression of the b7-2 antigen presentation coactivator is an unfavorable prognostic indicator for differentiated thyroid carcinoma of children and adolescents.
Shah R, Banks K, Patel A, Dogra S, Terrell R, Powers PA, Fenton C, Dinauer CA, Tuttle RM, Francis GL
J Clin Endocrinol Metab. 2002
PubMed ID: 12213904
-
Genetic background determines the requirement for B7 costimulation in induction of autoimmunity.
Jabs C, Greve B, Chang TT, Sobel RA, Sharpe AH, Kuchroo VK
Eur J Immunol. 2002
PubMed ID: 12207354
-
Role of B7 costimulatory molecules in the adjuvant activity of the heat-labile enterotoxin of Escherichia coli.
Martin M, Sharpe A, Clements JD, Michalek SM
J Immunol. 2002
PubMed ID: 12165495
-
Human neutrophil-expressed CD28 interacts with macrophage B7 to induce phosphatidylinositol 3-kinase-dependent IFN-gamma secretion and restriction of Leishmania growth.
Venuprasad K, Banerjee PP, Chattopadhyay S, Sharma S, Pal S, Parab PB, Mitra D, Saha B
J Immunol. 2002
PubMed ID: 12097397
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Impaired up-regulation of CD70 and CD86 in naive (CD27-) B cells from patients with common variable immunodeficiency (CVID).
Groth C, Drager R, Warnatz K, Wolff-Vorbeck G, Schmidt S, Eibel H, Schlesier M, Peter HH
Clin Exp Immunol. 2002
PubMed ID: 12100033
-
Memory Th2 effector cells can develop in the absence of B7-1/B7-2, CD28 interactions, and effector Th cells after priming with an intestinal nematode parasite.
Ekkens MJ, Liu Z, Liu Q, Foster A, Whitmire J, Pesce J, Sharpe AH, Urban JF, Gause WC
J Immunol. 2002
PubMed ID: 12055251
-
B cell receptor- and beta 2-adrenergic receptor-induced regulation of B7-2 (CD86) expression in B cells.
Kohm AP, Mozaffarian A, Sanders VM
J Immunol. 2002
PubMed ID: 12055247
-
Expression, refolding, purification, molecular characterization, crystallization, and preliminary X-ray analysis of the receptor binding domain of human B7-2.
Zhang X, Schwartz JC, Almo SC, Nathenson SG
Protein Expr Purif. 2002
PubMed ID: 12071705
-
Human plasma contains a soluble form of CD86 which is present at elevated levels in some leukaemia patients.
Hock BD, Patton WN, Budhia S, Mannari D, Roberts P, McKenzie JL
Leukemia. 2002
PubMed ID: 11986949
-
Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells.
Gao JX, Zhang H, Bai XF, Wen J, Zheng X, Liu J, Zheng P, Liu Y
J Exp Med. 2002
PubMed ID: 11956287
-
In vivo CD86 blockade inhibits CD4+ T cell activation, whereas CD80 blockade potentiates CD8+ T cell activation and CTL effector function.
Lang TJ, Nguyen P, Peach R, Gause WC, Via CS
J Immunol. 2002
PubMed ID: 11937530
-
B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo.
Bai XF, Liu J, May KF, Guo Y, Zheng P, Liu Y
Blood. 2002
PubMed ID: 11929778
-
CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes.
Williams JA, Sharrow SO, Adams AJ, Hodes RJ
J Immunol. 2002
PubMed ID: 11884443
-
Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1+, but not B7-2+, murine myelogenous leukemia.
LaBelle JL, Hanke CA, Blazar BR, Truitt RL
Blood. 2002
PubMed ID: 11877291
-
Distinct role of CD80 and CD86 in the regulation of the activation of B cell and B cell lymphoma.
Suvas S, Singh V, Sahdev S, Vohra H, Agrewala JN
J Biol Chem. 2002
PubMed ID: 11726649
-
CD80 (B7-1) and CD86 (B7-2) are functionally equivalent in the initiation and maintenance of CD4+ T-cell proliferation after activation with suboptimal doses of PHA.
Vasilevko V, Ghochikyan A, Holterman MJ, Agadjanyan MG
DNA Cell Biol. 2002
PubMed ID: 12015893
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Expression of CD86 in acute myelogenous leukemia is a marker of dendritic/monocytic lineage.
Re F, Arpinati M, Testoni N, Ricci P, Terragna C, Preda P, Ruggeri D, Senese B, Chirumbolo G, Martelli V, Urbini B, Baccarani M, Tura S, Rondelli D
Exp Hematol. 2002
PubMed ID: 11823047
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CTLA-4 regulates cell cycle progression during a primary immune response.
Greenwald RJ, Oosterwegel MA, van der Woude D, Kubal A, Mandelbrot DA, Boussiotis VA, Sharpe AH
Eur J Immunol. 2002
PubMed ID: 11807776
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B7-1 (CD80) and B7-2 (CD 86) expression in human tubular epithelial cells in vivo and in vitro.
Niemann-Masanek U, Mueller A, Yard BA, Waldherr R, van der Woude FJ
Nephron. 2002
PubMed ID: 12372936
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Differential effects of iron deficiency on the expression of CD80 and CD86 co-stimulatory receptors in mitogen-treated and untreated murine spleen cells.
Kuvibidila SR, Porretta C
J Cell Biochem. 2002
PubMed ID: 12210763
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Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses.
Fanales-Belasio E, Moretti S, Nappi F, Barillari G, Micheletti F, Cafaro A, Ensoli B
J Immunol. 2002
PubMed ID: 11751963
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A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition.
Coscoy L, Sanchez DJ, Ganem D
J Cell Biol. 2001
PubMed ID: 11756476
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IL-3 induces B7.2 (CD86) expression and costimulatory activity in human eosinophils.
Celestin J, Rotschke O, Falk K, Ramesh N, Jabara H, Strominger J, Geha RS
J Immunol. 2001
PubMed ID: 11714768
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Langerhans' cells in vernal keratoconjunctivitis express the costimulatory molecule B7-2 (CD86), but not B7-1 (CD80).
Abu-El-Asrar AM, Al-Kharashi SA, Al-Mansouri S, Missotten L, Geboes K
Eye. 2001
PubMed ID: 11702979
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Costimulatory molecules in the developing human gastrointestinal tract: a pathway for fetal allergen priming.
Jones CA, Vance GH, Power LL, Pender SL, Macdonald TT, Warner JO
J Allergy Clin Immunol. 2001
PubMed ID: 11496240
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B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.
Mandelbrot DA, Oosterwegel MA, Shimizu K, Yamada A, Freeman GJ, Mitchell RN, Sayegh MH, Sharpe AH
J Clin Invest. 2001
PubMed ID: 11285307
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Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
Schwartz JC, Zhang X, Fedorov AA, Nathenson SG, Almo SC
Nature. 2001
PubMed ID: 11279501
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Human thymus contains 2 distinct dendritic cell populations.
Vandenabeele S, Hochrein H, Mavaddat N, Winkel K, Shortman K
Blood. 2001
PubMed ID: 11238115
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Functional expression of a costimulatory B7.2 (CD86) protein on human salivary gland epithelial cells that interacts with the CD28 receptor, but has reduced binding to CTLA4.
Kapsogeorgou EK, Moutsopoulos HM, Manoussakis MN
J Immunol. 2001
PubMed ID: 11207262
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Acquisition of CD80 (B7-1) by T cells.
Sabzevari H, Kantor J, Jaigirdar A, Tagaya Y, Naramura M, Hodge J, Bernon J, Schlom J
J Immunol. 2001
PubMed ID: 11160311
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Identification of an alternatively spliced variant of human CD86 mRNA.
Magistrelli G, Caron G, Gauchat JF, Jeannin P, Bonnefoy JY, Delneste Y
Biochem Biophys Res Commun. 2001
PubMed ID: 11162656
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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CD28-B7-2 but not CD28-B7-1 interaction is required for T cell costimulation in experimental obliterative bronchiolitis in the rat.
Tikkanen JM, Lemström KB, Koskinen PK
Transplant Proc. 2001
PubMed ID: 11266944
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M cell pockets of human Peyer's patches are specialized extensions of germinal centers.
Yamanaka T, Straumfors A, Morton H, Fausa O, Brandtzaeg P, Farstad I
Eur J Immunol. 2001
PubMed ID: 11169444
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Bi-directional activation between human airway smooth muscle cells and T lymphocytes: role in induction of altered airway responsiveness.
Hakonarson H, Kim C, Whelan R, Campbell D, Grunstein MM
J Immunol. 2001
PubMed ID: 11123305
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Functional equivalency of B7-1 and B7-2 for costimulating plasmid DNA vaccine-elicited CTL responses.
Santra S, Barouch DH, Jackson SS, Kuroda MJ, Schmitz JE, Lifton MA, Sharpe AH, Letvin NL
J Immunol. 2000
PubMed ID: 11120800
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, Fitz LJ, Malenkovich N, Okazaki T, Byrne MC, Horton HF, Fouser L, Carter L, Ling V, Bowman MR, Carreno BM, Collins M, Wood CR, Honjo T
J Exp Med. 2000
PubMed ID: 11015443
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New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus.
Matsushita M, Tsuchiya N, Oka T, Yamane A, Tokunaga K
Genes Immun. 2000
PubMed ID: 11196673
-
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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Molecular cloning of the cDNAs encoding the feline B-lymphocyte activation antigen B7-1 (CD80) and B7-2 (CD86) homologues which interact with human CTLA4-Ig.
Nishimura Y, Shimojima M, Miyazawa T, Sato E, Nakamura K, Izumiya Y, Ikeda Y, Mikami T, Takahashi E
Eur J Immunogenet. 2000
PubMed ID: 11029611
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Costimulation of T cells.
Bugeon L, Dallman MJ
Am J Respir Crit Care Med. 2000
PubMed ID: 11029388
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Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus.
Liang B, Kashgarian MJ, Sharpe AH, Mamula MJ
J Immunol. 2000
PubMed ID: 10975864
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Soluble CD86 is a costimulatory molecule for human T lymphocytes.
Jeannin P, Magistrelli G, Aubry JP, Caron G, Gauchat JF, Renno T, Herbault N, Goetsch L, Blaecke A, Dietrich PY, Bonnefoy JY, Delneste Y
Immunity. 2000
PubMed ID: 11021528
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Stimulation of the B cell receptor, CD86 (B7-2), and the beta 2-adrenergic receptor intrinsically modulates the level of IgG1 and IgE produced per B cell.
Kasprowicz DJ, Kohm AP, Berton MT, Chruscinski AJ, Sharpe A, Sanders VM
J Immunol. 2000
PubMed ID: 10878340
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Interleukin-15 up-regulates the expression of CD154 on synovial fluid T cells.
Möttönen M, Isomäki P, Luukkainen R, Toivanen P, Punnonen J, Lassila O
Immunology. 2000
PubMed ID: 10886401
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Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Faslpr mice.
Kinoshita K, Tesch G, Schwarting A, Maron R, Sharpe AH, Kelley VR
J Immunol. 2000
PubMed ID: 10820290
-
Regulatory role of mature B cells in a murine model of inflammatory bowel disease.
Mizoguchi E, Mizoguchi A, Preffer FI, Bhan AK
Int Immunol. 2000
PubMed ID: 10784605
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The role of B7 costimulation in CD4/CD8 T cell homeostasis.
Yu X, Fournier S, Allison JP, Sharpe AH, Hodes RJ
J Immunol. 2000
PubMed ID: 10725709
-
B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness.
Mark DA, Donovan CE, De Sanctis GT, He HZ, Cernadas M, Kobzik L, Perkins DL, Sharpe A, Finn PW
Am J Respir Cell Mol Biol. 2000
PubMed ID: 10696062
-
Resting B lymphocytes as APC for naive T lymphocytes: dependence on CD40 ligand/CD40.
Evans DE, Munks MW, Purkerson JM, Parker DC
J Immunol. 2000
PubMed ID: 10623811
-
B7 costimulation is critical for antibody class switching and CD8(+) cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus.
McAdam AJ, Farkash EA, Gewurz BE, Sharpe AH
J Virol. 2000
PubMed ID: 10590107
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New forms of dog CD80 and CD86 transcripts that encode secreted B7 molecules.
Yang S, Sim GK
Immunogenetics. 1999
PubMed ID: 10630300
-
Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts.
Mandelbrot DA, Furukawa Y, McAdam AJ, Alexander SI, Libby P, Mitchell RN, Sharpe AH
J Immunol. 1999
PubMed ID: 10490971
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Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis.
Chang TT, Jabs C, Sobel RA, Kuchroo VK, Sharpe AH
J Exp Med. 1999
PubMed ID: 10477557
-
Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa.
Nakazawa A, Watanabe M, Kanai T, Yajima T, Yamazaki M, Ogata H, Ishii H, Azuma M, Hibi T
Gastroenterology. 1999
PubMed ID: 10464129
-
The role of CTLA-4 in regulating Th2 differentiation.
Oosterwegel MA, Mandelbrot DA, Boyd SD, Lorsbach RB, Jarrett DY, Abbas AK, Sharpe AH
J Immunol. 1999
PubMed ID: 10453003
-
B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies.
Liang B, Gee RJ, Kashgarian MJ, Sharpe AH, Mamula MJ
J Immunol. 1999
PubMed ID: 10438978
-
B7-2 is required for the progression but not the initiation of the type 2 immune response to a gastrointestinal nematode parasite.
Greenwald RJ, Urban JF, Ekkens MJ, Chen S, Nguyen D, Fang H, Finkelman FD, Sharpe AH, Gause WC
J Immunol. 1999
PubMed ID: 10201938
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Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: reversal of elicited T cell cytokine profile and partial inhibition of egg granuloma formation.
Hernandez HJ, Sharpe AH, Stadecker MJ
J Immunol. 1999
PubMed ID: 10072537
-
CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28.
Slavik JM, Hutchcroft JE, Bierer BE
J Biol Chem. 1999
PubMed ID: 9915850
-
B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).
Mandelbrot DA, McAdam AJ, Sharpe AH
J Exp Med. 1999
PubMed ID: 9892625
-
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
-
Gamma-ray irradiation induces B7.1 costimulatory molecule neoexpression in various murine tumor cells.
Morel A, Fernandez N, de La Coste A, Haddada H, Viguier M, Polla BS, Antoine B, Kahn A
Cancer Immunol Immunother. 1998
PubMed ID: 9690456
-
Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice.
Detmar M, Brown LF, Schön MP, Elicker BM, Velasco P, Richard L, Fukumura D, Monsky W, Claffey KP, Jain RK
J Invest Dermatol. 1998
PubMed ID: 9665379
-
B7-CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge.
Zheng P, Wu Y, Guo Y, Lee C, Liu Y
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9600957
-
Expression of CD86 on human marrow CD34(+) cells identifies immunocompetent committed precursors of macrophages and dendritic cells.
Ryncarz RE, Anasetti C
Blood. 1998
PubMed ID: 9573027
-
Development of murine allergic asthma is dependent upon B7-2 costimulation.
Keane-Myers AM, Gause WC, Finkelman FD, Xhou XD, Wills-Karp M
J Immunol. 1998
PubMed ID: 9551945
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Upregulation of B7.2, but not B7.1, on B cells from patients with allergic asthma.
Hofer MF, Jirapongsananuruk O, Trumble AE, Leung DY
J Allergy Clin Immunol. 1998
PubMed ID: 9449507
-
Gene immunotherapy in murine acute myeloid leukemia: granulocyte-macrophage colony-stimulating factor tumor cell vaccines elicit more potent antitumor immunity compared with B7 family and other cytokine vaccines.
Dunussi-Joannopoulos K, Dranoff G, Weinstein HJ, Ferrara JL, Bierer BE, Croop JM
Blood. 1998
PubMed ID: 9414288
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Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice.
Van Parijs L, Sethna MP, Schweitzer AN, Borriello F, Sharpe AH, Abbas AK
J Immunol. 1997
PubMed ID: 9548473
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Regulation of self-tolerance by CD80/CD86 interactions.
Lu P, Wang YL, Linsley PS
Curr Opin Immunol. 1997
PubMed ID: 9492990
-
The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3.
Reeves RH, Patch D, Sharpe AH, Borriello F, Freeman GJ, Edelhoff S, Disteche C
Mamm Genome. 1997
PubMed ID: 9250865
-
High-resolution recombinational map of mouse chromosome 16.
Reeves RH, Rue EE, Citron MP, Cabin DE
Genomics. 1997
PubMed ID: 9244437
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Characterization of rat CD80 and CD86 by molecular cloning and mAb.
Maeda K, Sato T, Azuma M, Yagita H, Okumura K
Int Immunol. 1997
PubMed ID: 9237108
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Transfection of the gene for B7-1 but not B7-2 can induce immunity to murine malignant mesothelioma.
Leong CC, Marley JV, Loh S, Milech N, Robinson BW, Garlepp MJ
Int J Cancer. 1997
PubMed ID: 9139887
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B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation.
Borriello F, Sethna MP, Boyd SD, Schweitzer AN, Tivol EA, Jacoby D, Strom TB, Simpson EM, Freeman GJ, Sharpe AH
Immunity. 1997
PubMed ID: 9075931
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Lck regulates Vav activation of members of the Rho family of GTPases.
Han J, Das B, Wei W, Van Aelst L, Mosteller RD, Khosravi-Far R, Westwick JK, Der CJ, Broek D
Mol Cell Biol. 1997
PubMed ID: 9032261
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Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection.
Hancock WW, Sayegh MH, Zheng XG, Peach R, Linsley PS, Turka LA
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8943044
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In situ analysis of B7-2 costimulatory, major histocompatibility complex class II, and adhesion molecule expression in schistosomal egg granulomas.
Rathore A, Sacristán C, Ricklan DE, Flores Villanueva PO, Stadecker MJ
Am J Pathol. 1996
PubMed ID: 8686742
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Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function.
Kariv I, Truneh A, Sweet RW
J Immunol. 1996
PubMed ID: 8683128
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Expression and function of B7-1 and B7-2 in hapten-induced contact sensitivity.
Reiser H, Schneeberger EE
Eur J Immunol. 1996
PubMed ID: 8625983
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Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): analysis by site directed mutagenesis.
Truneh A, Reddy M, Ryan P, Lyn SD, Eichman C, Couez D, Hurle MR, Sekaly RP, Olive D, Sweet R
Mol Immunol. 1996
PubMed ID: 8649453
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Glycosylphosphatidylinositol-modified murine B7-1 and B7-2 retain costimulator function.
Brunschwig EB, Levine E, Trefzer U, Tykocinski ML
J Immunol. 1995
PubMed ID: 7499830
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Differential expression of alternate mB7-2 transcripts.
Borriello F, Oliveros J, Freeman GJ, Nadler LM, Sharpe AH
J Immunol. 1995
PubMed ID: 7499829
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Localization in situ of the co-stimulatory molecules B7.1, B7.2, CD40 and their ligands in normal human lymphoid tissue.
Vyth-Dreese FA, Dellemijn TA, Majoor D, de Jong D
Eur J Immunol. 1995
PubMed ID: 7489738
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CD86 (B70/B7-2) on endothelial cells co-stimulates allogeneic CD4+ T cells.
Seino K, Azuma M, Bashuda H, Fukao K, Yagita H, Okumura K
Int Immunol. 1995
PubMed ID: 7495740
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Activation of human peripheral blood dendritic cells induces the CD86 co-stimulatory molecule.
McLellan AD, Starling GC, Williams LA, Hock BD, Hart DN
Eur J Immunol. 1995
PubMed ID: 7542604
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Structure-function studies on the biosynthesis and bioactivity of the precursor convertase PC2 and the formation of the PC2/7B2 complex.
Benjannet S, Lusson J, Hamelin J, Savaria D, Chrétien M, Seidah NG
FEBS Lett. 1995
PubMed ID: 7720862
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Cloning and sequencing of the rabbit gene encoding T-cell costimulatory molecules.
Isono T, Seto A
Immunogenetics. 1995
PubMed ID: 7642234
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Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86).
Jellis CL, Wang SS, Rennert P, Borriello F, Sharpe AH, Green NR, Gray GS
Immunogenetics. 1995
PubMed ID: 7541777
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Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation.
Prabhu Das MR, Zamvil SS, Borriello F, Weiner HL, Sharpe AH, Kuchroo VK
Eur J Immunol. 1995
PubMed ID: 7531145
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CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.
Lanier LL, O'Fallon S, Somoza C, Phillips JH, Linsley PS, Okumura K, Ito D, Azuma M
J Immunol. 1995
PubMed ID: 7527824
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The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.
Inaba K, Witmer-Pack M, Inaba M, Hathcock KS, Sakuta H, Azuma M, Yagita H, Okumura K, Linsley PS, Ikehara S, Muramatsu S, Hodes RJ, Steinman RM
J Exp Med. 1994
PubMed ID: 7525841
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The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen.
Engel P, Gribben JG, Freeman GJ, Zhou LJ, Nozawa Y, Abe M, Nadler LM, Wakasa H, Tedder TF
Blood. 1994
PubMed ID: 7520767
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Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.
Lenschow DJ, Sperling AI, Cooke MP, Freeman G, Rhee L, Decker DC, Gray G, Nadler LM, Goodnow CC, Bluestone JA
J Immunol. 1994
PubMed ID: 7519638
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Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.
Hathcock KS, Laszlo G, Pucillo C, Linsley P, Hodes RJ
J Exp Med. 1994
PubMed ID: 7519245
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IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2.
Stack RM, Lenschow DJ, Gray GS, Bluestone JA, Fitch FW
J Immunol. 1994
PubMed ID: 7515912
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Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.
Larsen CP, Ritchie SC, Hendrix R, Linsley PS, Hathcock KS, Hodes RJ, Lowry RP, Pearson TC
J Immunol. 1994
PubMed ID: 7514631
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Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule.
Chen C, Gault A, Shen L, Nabavi N
J Immunol. 1994
PubMed ID: 7513726
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Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.
Freeman GJ, Borriello F, Hodes RJ, Reiser H, Gribben JG, Ng JW, Kim J, Goldberg JM, Hathcock K, Laszlo G
J Exp Med. 1993
PubMed ID: 7504059
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Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation.
Freeman GJ, Gribben JG, Boussiotis VA, Ng JW, Restivo VA, Lombard LA, Gray GS, Nadler LM
Science. 1993
PubMed ID: 7694363
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B70 antigen is a second ligand for CTLA-4 and CD28.
Azuma M, Ito D, Yagita H, Okumura K, Phillips JH, Lanier LL, Somoza C
Nature. 1993
PubMed ID: 7694153
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Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells.
Morse HC
J Immunol. 1992
PubMed ID: 1431091
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Recombination between kappa chain genetic markers and the Lyt-3 locus.
Gibson DM, Maclean SJ, Cherry M
Immunogenetics. 1983
PubMed ID: 6411613
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