Home CD80
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Regions Overlapping this Feature:
Rat: 1
Linkage Regions: 1 Available
Linkage Regions: 1 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes | Linkage and Congenic Studies |
|---|---|---|---|---|---|
| Iddm17 | Rat | chr11:19445919..87759784 | 68.31 | 594 |
(Human) GRCh37 - chr3:119243140..119278481 (35.34 kb) View in Genome Browser
(Mouse) NCBIM37 - chr16:38455641..38495821 (40.18 kb) View in Genome Browser
(Rat) RGSC3.4 - chr11:64045341..64070083 (24.74 kb) View in Genome Browser
HaemAtlas Expression Table for CD80:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
| Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for CD80:The CD80 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| CD80 | CTLA4 | HPRD, IntAct | empirical | 7545666 11279502 21982860 |
| CD80 | CD274 | IntAct | empirical | 21982860 21884581 |
| CD80 | NGFR | IntAct | empirical | 21982860 |
| CD80 | CD28 | HPRD, IntAct, BioGRID | empirical | 7545666 21982860 |
| CD80 | CD80 | HPRD, IntAct, BioGRID | empirical | 11279502 21884581 |
| CD80 | CD86 | HPRD | empirical | 12606712 |
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Type 1 Diabetes Publications: 20
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The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo.
Paterson AM, Brown KE, Keir ME, Vanguri VK, Riella LV, Chandraker A, Sayegh MH, Blazar BR, Freeman GJ, Sharpe AH
J Immunol. 2011
PubMed ID: 21697456
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Clinical significance of b7-h1 and b7-1 expressions in pancreatic carcinoma.
Wang L, Ma Q, Chen X, Guo K, Li J, Zhang M
World J Surg. 2010
PubMed ID: 20145927
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CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice.
Pang S, Zhang L, Wang H, Yi Z, Li L, Gao L, Zhao J, Tisch R, Katz JD, Wang B
Eur J Immunol. 2009
PubMed ID: 19658094
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B7-1 and B7-2 differentially control peripheral homeostasis of CD4(+)CD25(+)Foxp3(+) regulatory T cells.
Zeng M, Guinet E, Nouri-Shirazi M
Transpl Immunol. 2009
PubMed ID: 18848987
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Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation.
Perez N, Karumuthil-Melethil S, Li R, Prabhakar BS, Holterman MJ, Vasu C
J Immunol. 2008
PubMed ID: 18453575
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GAD-IgG-inducing CD4+Foxp3+Treg cells suppressing diabetes are involved in the increasing ratio of CD80+:CD86+ CELLS in NOD mice.
Wang R, Han G, Wang J, Song L, Chen G, Xu R, Zhang C, Yu M, Qian J, Shen B, Li Y
Arch Med Res. 2008
PubMed ID: 18279702
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Cytotoxic T cell-mediated diabetes in RIP-CD80 transgenic mice: autoantigen peptide sensitivity and fine specificity.
Pechhold K, Chakrabarty S, Harlan DM
Ann N Y Acad Sci. 2007
PubMed ID: 17376836
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B7-1 mediated costimulation regulates pancreatic autoimmunity.
Yadav D, Fine C, Azuma M, Sarvetnick N
Mol Immunol. 2007
PubMed ID: 17289146
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Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA
J Clin Invest. 2006
PubMed ID: 16886063
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The influence of the major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice.
Wong FS, Du W, Thomas IJ, Wen L
Diabetes. 2005
PubMed ID: 15983204
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Dysregulated B7-1 and B7-2 expression on nonobese diabetic mouse B cells is associated with increased T cell costimulation and the development of insulitis.
Hussain S, Delovitch TL
J Immunol. 2005
PubMed ID: 15634886
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Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7.1 mice.
Karges W, Pechhold K, Al Dahouk S, Riegger I, Rief M, Wissmann A, Schirmbeck R, Barth C, Boehm BO
Diabetes. 2002
PubMed ID: 12401715
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Role of the B7-CD28/CTLA-4 pathway in autoimmune disease.
Chang TT, Kuchroo VK, Sharpe AH
Curr Dir Autoimmun. 2002
PubMed ID: 11826754
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Low dose streptozotocin-induced diabetes in rat insulin promoter-mCD80-transgenic mice is T cell autoantigen-specific and CD28 dependent.
Pechhold K, Patterson NB, Blum C, Fleischacker CL, Boehm BO, Harlan DM
J Immunol. 2001
PubMed ID: 11160314
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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA
Immunity. 2000
PubMed ID: 10795741
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Low CD86 expression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-4 up-regulation.
Dahlén E, Hedlund G, Dawe K
J Immunol. 2000
PubMed ID: 10679081
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A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade.
Girvin AM, Dal Canto MC, Rhee L, Salomon B, Sharpe A, Bluestone JA, Miller SD
J Immunol. 2000
PubMed ID: 10605004
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The role of donor and recipient B7-1 (CD80) in allograft rejection.
Zheng XX, Sayegh MH, Zheng XG, Li Y, Linsley PS, Peach R, Borriello F, Strom TB, Sharpe AH, Turka LA
J Immunol. 1997
PubMed ID: 9233610
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Pancreatic expression of B7 co-stimulatory molecules in the non-obese diabetic mouse.
Stephens LA, Kay TW
Int Immunol. 1995
PubMed ID: 8746558
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Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse.
Wong S, Guerder S, Visintin I, Reich EP, Swenson KE, Flavell RA, Janeway CA
Diabetes. 1995
PubMed ID: 7533734
Publications: 408
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Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation.
O'Sullivan BJ, Pai S, Street S, An X, MacDonald KP, Wong M, Strutton G, Gerondakis S, Steptoe RJ, de St Groth BF, Hill GR, Thomas R
J Immunol. 2011
PubMed ID: 21900177
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Estrogen promotes B cell activation in vitro through down-regulating CD80 molecule expression.
Fu Y, Li L, Liu X, Ma C, Zhang J, Jiao Y, You L, Chen ZJ, Zhao Y
Gynecol Endocrinol. 2011
PubMed ID: 21726119
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The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo.
Yang J, Riella LV, Chock S, Liu T, Zhao X, Yuan X, Paterson AM, Watanabe T, Vanguri V, Yagita H, Azuma M, Blazar BR, Freeman GJ, Rodig SJ, Sharpe AH, Chandraker A, Sayegh MH
J Immunol. 2011
PubMed ID: 21697455
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Sustained antibody responses depend on CD28 function in bone marrow-resident plasma cells.
Rozanski CH, Arens R, Carlson LM, Nair J, Boise LH, Chanan-Khan AA, Schoenberger SP, Lee KP
J Exp Med. 2011
PubMed ID: 21690252
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Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection.
Seung E, Cho JL, Sparwasser T, Medoff BD, Luster AD
J Immunol. 2011
PubMed ID: 21555535
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Tumor cell programmed death ligand 1-mediated T cell suppression is overcome by coexpression of CD80.
Haile ST, Bosch JJ, Agu NI, Zeender AM, Somasundaram P, Srivastava MK, Britting S, Wolf JB, Ksander BR, Ostrand-Rosenberg S
J Immunol. 2011
PubMed ID: 21555531
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Expression and distribution of S-100, CD83, and costimulatory molecules (CD80 and CD86) in tissues of thyroid papillary carcinoma.
Xu WC, Li ZB, Chen YR, Li XT, Huang JX, Li YG, Chen SR
Cancer Invest. 2011
PubMed ID: 21469977
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B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus.
Salek-Ardakani S, Choi YS, Rafii-El-Idrissi Benhnia M, Flynn R, Arens R, Shoenberger S, Crotty S, Croft M, Salek-Ardakani S
J Immunol. 2011
PubMed ID: 21441451
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The effect of gluten-free diet on Th1-Th2-Th3-associated intestinal immune responses in celiac disease.
Lahdenperä A, Ludvigsson J, Fälth-Magnusson K, Högberg L, Vaarala O
Scand J Gastroenterol. 2011
PubMed ID: 21288140
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Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, Baker J, Jeffery LE, Kaur S, Briggs Z, Hou TZ, Futter CE, Anderson G, Walker LS, Sansom DM
Science. 2011
PubMed ID: 21474713
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Clonorchis sinensis-derived total protein attenuates airway inflammation in murine asthma model by inducing regulatory T cells and modulating dendritic cell functions.
Jeong YI, Kim SH, Ju JW, Cho SH, Lee WJ, Park JW, Park YM, Lee SE
Biochem Biophys Res Commun. 2011
PubMed ID: 21440530
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Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo.
Dolfi DV, Duttagupta PA, Boesteanu AC, Mueller YM, Oliai CH, Borowski AB, Katsikis PD
J Immunol. 2011
PubMed ID: 21389258
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Differential B7-CD28 costimulatory requirements for stable and inflationary mouse cytomegalovirus-specific memory CD8 T cell populations.
Arens R, Loewendorf A, Redeker A, Sierro S, Boon L, Klenerman P, Benedict CA, Schoenberger SP
J Immunol. 2011
PubMed ID: 21357256
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Triple expression of B7-1, B7-2 and 4-1BBL enhanced antitumor immune response against mouse H22 hepatocellular carcinoma.
Li G, Wu X, Zhang F, Li X, Sun B, Yu Y, Yin A, Deng L, Yin J, Wang X
J Cancer Res Clin Oncol. 2011
PubMed ID: 20563597
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Host APCs augment in vivo expansion of donor natural regulatory T cells via B7H1/B7.1 in allogeneic recipients.
Yi T, Li X, Yao S, Wang L, Chen Y, Zhao D, Johnston HF, Young JS, Liu H, Todorov I, Forman SJ, Chen L, Zeng D
J Immunol. 2011
PubMed ID: 21263067
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Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells.
Kanada S, Nishiyama C, Nakano N, Suzuki R, Maeda K, Hara M, Kitamura N, Ogawa H, Okumura K
Blood. 2011
PubMed ID: 21119111
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Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation.
Bar-On L, Birnberg T, Kim KW, Jung S
Eur J Immunol. 2011
PubMed ID: 21267999
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Stromal cells' B7-1 is a key stimulatory molecule for interleukin-10 production by HOZOT, a multifunctional regulatory T-cell line.
Otani T, Tsuji-Takayama K, Okochi A, Yamamoto M, Takeuchi M, Yamasaki F, Nakamura S, Kibata M
Immunol Cell Biol. 2011
PubMed ID: 20628373
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Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
Mells GF, Floyd JA, Morley KI, Cordell HJ, Franklin CS, Shin SY, Heneghan MA, Neuberger JM, Donaldson PT, Day DB, Ducker SJ, Muriithi AW, Wheater EF, Hammond CJ, Dawwas MF, UK PBC Consortium, Wellcome Trust Case Control Consortium 3, Jones DE, Peltonen L, Alexander GJ, Sandford RN, Anderson CA
Nat Genet. 2011
PubMed ID: 21399635
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Enhancement of suboptimal CD8 cytotoxic T cell effector function in vivo using antigen-specific CD80 defective T cells.
Puliaeva I, Soloviova K, Puliaiev M, Lang T, Puliaev R, Via CS
J Immunol. 2011
PubMed ID: 21115734
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Early immunological response to German cockroach frass exposure induces a Th2/Th17 environment.
Page K, Zhou P, Ledford JR, Day SB, Lutfi R, Dienger K, Lewkowich IP
J Innate Immun. 2011
PubMed ID: 21051864
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Differential requirements for CD80/86-CD28 costimulation in primary and memory CD4 T cell responses to vaccinia virus.
Fuse S, Tsai CY, Rommereim LM, Zhang W, Usherwood EJ
Cell Immunol. 2011
PubMed ID: 21040905
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B7-mediated costimulation of CD4 T cells constrains cytomegalovirus persistence.
Arens R, Loewendorf A, Her MJ, Schneider-Ohrum K, Shellam GR, Janssen E, Ware CF, Schoenberger SP, Benedict CA
J Virol. 2011
PubMed ID: 20980516
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Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension.
Vinh A, Chen W, Blinder Y, Weiss D, Taylor WR, Goronzy JJ, Weyand CM, Harrison DG, Guzik TJ
Circulation. 2010
PubMed ID: 21126972
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TIM-3: a novel regulatory molecule of alloimmune activation.
Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N
J Immunol. 2010
PubMed ID: 20956339
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Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
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A multiplex MALDI-TOF MS approach facilitates genotyping of DNA from formalin-fixed paraffin-embedded tumour specimens.
Horn H, Pott C, Kalla J, Dreyling M, Rosenwald A, Ott G, Schwab M, Schaeffeler E
Pharmacogenet Genomics. 2010
PubMed ID: 20802378
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Cutting edge: Hematopoietic-derived APCs select regulatory T cells in thymus.
Román E, Shino H, Qin FX, Liu YJ
J Immunol. 2010
PubMed ID: 20802149
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Alveolar macrophages stimulate enhanced cytokine production by pulmonary CD4+ T-lymphocytes in an exacerbation of murine chronic asthma.
Herbert C, Scott MM, Scruton KH, Keogh RP, Yuan KC, Hsu K, Siegle JS, Tedla N, Foster PS, Kumar RK
Am J Pathol. 2010
PubMed ID: 20724599
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Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.
Fukaya T, Takagi H, Sato Y, Sato K, Eizumi K, Taya H, Shin T, Chen L, Dong C, Azuma M, Yagita H, Malissen B, Sato K
Blood. 2010
PubMed ID: 20574047
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The Association between Polymorphisms of B7 Molecules (CD80 and CD86) and Graves' Ophthalmopathy in a Taiwanese Population.
Liao WL, Chen RH, Lin HJ, Liu YH, Chen WC, Tsai Y, Wan L, Tsai FJ
Ophthalmology. 2010
PubMed ID: 20884055
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Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.
Chang JS, Wiemels JL, Chokkalingam AP, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Green J, May SL, Kiley VA, Wiencke JK, Buffler PA
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20716621
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B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses.
Lin PY, Sun L, Thibodeaux SR, Ludwig SM, Vadlamudi RK, Hurez VJ, Bahar R, Kious MJ, Livi CB, Wall SR, Chen L, Zhang B, Shin T, Curiel TJ
J Immunol. 2010
PubMed ID: 20686128
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Peripheral blood gene expression of B7 and CD28 family members associated with tumor progression and microscopic lymphovascular invasion in colon cancer patients.
Lee H, Kim JH, Yang SY, Kong J, Oh M, Jeong DH, Chung JI, Bae KB, Shin JY, Hong KH, Choi I
J Cancer Res Clin Oncol. 2010
PubMed ID: 20140740
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B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance.
Park JJ, Omiya R, Matsumura Y, Sakoda Y, Kuramasu A, Augustine MM, Yao S, Tsushima F, Narazaki H, Anand S, Liu Y, Strome SE, Chen L, Tamada K
Blood. 2010
PubMed ID: 20472828
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[Expression and significance of CD80/CD86 in renal tissue of lupus nephritis].
Sui MS, Zhou J, Jia XB, Mu SH, Liu XG, Ji Y, Xie RJ
Zhonghua Nei Ke Za Zhi. 2010
PubMed ID: 20979791
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Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.
Ying H, Yang L, Qiao G, Li Z, Zhang L, Yin F, Xie D, Zhang J
J Immunol. 2010
PubMed ID: 20601598
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The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus.
Grujic M, Bartholdy C, Remy M, Pinschewer DD, Christensen JP, Thomsen AR
J Immunol. 2010
PubMed ID: 20601595
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Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R
Pediatr Pulmonol. 2010
PubMed ID: 20503287
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Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL, Thio CL
J Infect Dis. 2010
PubMed ID: 20331378
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New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
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Multiple common variants for celiac disease influencing immune gene expression.
Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Adány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek WH, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA
Nat Genet. 2010
PubMed ID: 20190752
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Lack of B7-1 and B7-2 costimulatory molecules modulates the severity of group B Streptococcus-induced arthritis.
Puliti M, Bistoni F, Tissi L
Microbes Infect. 2010
PubMed ID: 20114085
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Pollen-induced oxidative stress influences both innate and adaptive immune responses via altering dendritic cell functions.
Csillag A, Boldogh I, Pazmandi K, Magyarics Z, Gogolak P, Sur S, Rajnavolgyi E, Bacsi A
J Immunol. 2010
PubMed ID: 20118277
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Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation.
Bhatia S, Sun K, Almo SC, Nathenson SG, Hodes RJ
J Immunol. 2010
PubMed ID: 20065109
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PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis.
Ishizaki Y, Yukaya N, Kusuhara K, Kira R, Torisu H, Ihara K, Sakai Y, Sanefuji M, Pipo-Deveza JR, Silao CL, Sanchez BC, Lukban MB, Salonga AM, Hara T
Hum Genet. 2010
PubMed ID: 20066438
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CpG-ODN and MPLA prevent mortality in a murine model of post-hemorrhage-Staphyloccocus aureus pneumonia.
Roquilly A, Gautreau L, Segain JP, de Coppet P, Sebille V, Jacqueline C, Caillon J, Potel G, Lejus C, Josien R, Asehnoune K
PLoS One. 2010
PubMed ID: 20949109
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B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion.
Rau FC, Dieter J, Luo Z, Priest SO, Baumgarth N
J Immunol. 2009
PubMed ID: 19933871
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Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease.
Freeman CM, Martinez FJ, Han MK, Ames TM, Chensue SW, Todt JC, Arenberg DA, Meldrum CA, Getty C, McCloskey L, Curtis JL
Am J Respir Crit Care Med. 2009
PubMed ID: 19729666
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[Regulatory effect of thalidomide on the expression of costimulatory molecules in patients with multiple myeloma].
Yang Y, Zhang WG, He AL, Yang HY, Wang Y, Tian W
Nan Fang Yi Ke Da Xue Xue Bao. 2009
PubMed ID: 20034904
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CD80 blockade enhance glucocorticoid-induced leucine zipper expression and suppress experimental autoimmune encephalomyelitis.
Dudhgaonkar SP, Janardhanam SB, Kodumudi KN, Srinivasan M
J Immunol. 2009
PubMed ID: 19917693
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Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients.
Segat L, Milanese M, Pirulli D, Trevisiol C, Lupo F, Salizzoni M, Amoroso A, Crovella S
J Gastroenterol Hepatol. 2009
PubMed ID: 19817957
-
B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function.
Ruffner MA, Kim SH, Bianco NR, Francisco LM, Sharpe AH, Robbins PD
Eur J Immunol. 2009
PubMed ID: 19757438
-
Regulatory T cells modulate postischemic neovascularization.
Zouggari Y, Ait-Oufella H, Waeckel L, Vilar J, Loinard C, Cochain C, Récalde A, Duriez M, Levy BI, Lutgens E, Lutgens E, Mallat Z, Silvestre JS
Circulation. 2009
PubMed ID: 19770391
-
Types I and II interferons upregulate the costimulatory CD80 molecule in monocytes via interferon regulatory factor-1.
Bauvois B, Nguyen J, Tang R, Billard C, Kolb JP
Biochem Pharmacol. 2009
PubMed ID: 19433065
-
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
-
The mouse C2C12 myoblast cell surface N-linked glycoproteome: Identification, glycosite occupancy, and membrane orientation.
Gundry RL, Raginski K, Tarasova Y, Tchernyshyov I, Bausch-Fluck D, Elliott ST, Boheler KR, Van Eyk JE, Wollscheid B
Mol Cell Proteomics. 2009
PubMed ID: 19656770
-
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C
Gut. 2009
PubMed ID: 19240061
-
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
-
Distinct roles of CD28- and CD40 ligand-mediated costimulation in the development of protective immunity and pathology during Chlamydia muridarum urogenital infection in mice.
Chen L, Cheng W, Shivshankar P, Lei L, Zhang X, Wu Y, Yeh IT, Zhong G
Infect Immun. 2009
PubMed ID: 19398542
-
B-1 cell-derived monoclonal antibodies and costimulatory molecules.
Lee J, Suh J, Choi J
J Surg Res. 2009
PubMed ID: 19201420
-
Cutting edge: CD28 engagement releases antigen-activated invariant NKT cells from the inhibitory effects of PD-1.
Wang J, Cheng L, Wondimu Z, Swain M, Santamaria P, Yang Y
J Immunol. 2009
PubMed ID: 19454657
-
Lentiviral gene transfer of CTLA4 generates B cells with reduced costimulatory properties.
Vogt B, Warncke M, Micheel B, Sheriff A
Autoimmunity. 2009
PubMed ID: 19811307
-
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
-
CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.
Kurtz J, Raval F, Vallot C, Der J, Sykes M
Blood. 2009
PubMed ID: 19179471
-
CD28/B7-mediated co-stimulation is critical for early control of murine cytomegalovirus infection.
Cook CH, Chen L, Wen J, Zimmerman P, Zhang Y, Trgovcich J, Liu Y, Gao JX
Viral Immunol. 2009
PubMed ID: 19326996
-
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
Pediatr Infect Dis J. 2009
PubMed ID: 19258923
-
B7 costimulation is critical for host control of chronic Mycobacterium tuberculosis infection.
Bhatt K, Uzelac A, Mathur S, McBride A, Potian J, Salgame P
J Immunol. 2009
PubMed ID: 19265158
-
Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells.
Salek-Ardakani S, Arens R, Flynn R, Sette A, Schoenberger SP, Croft M
J Immunol. 2009
PubMed ID: 19234186
-
B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation.
Talay O, Shen CH, Chen L, Chen J
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19202065
-
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance.
Friedline RH, Brown DS, Nguyen H, Kornfeld H, Lee J, Zhang Y, Appleby M, Der SD, Kang J, Chambers CA
J Exp Med. 2009
PubMed ID: 19188497
-
Biological characteristics of dendritic cells derived from peripheral blood of patients with epithelial ovarian cancer.
Lan CY, Liu JH, Xia JC, Zheng LM
Chin J Cancer. 2009
PubMed ID: 19550123
-
Urinary CD80 excretion increases in idiopathic minimal-change disease.
Garin EH, Diaz LN, Mu W, Wasserfall C, Araya C, Segal M, Johnson RJ
J Am Soc Nephrol. 2009
PubMed ID: 19056875
-
Cross-linking of CD80 on CD4+ T cells activates a calcium-dependent signaling pathway.
Podojil JR, Miller SD
J Immunol. 2009
PubMed ID: 19124719
-
Impaired immune responses in the lungs of aged mice following influenza infection.
Toapanta FR, Ross TM
Respir Res. 2009
PubMed ID: 19922665
-
Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis.
Nolan A, Kobayashi H, Naveed B, Kelly A, Hoshino Y, Hoshino S, Karulf MR, Rom WN, Weiden MD, Gold JA
PLoS One. 2009
PubMed ID: 19672303
-
Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity.
Wong SC, Tan AH, Lam KP
Cell Immunol. 2009
PubMed ID: 19249753
-
B7-1 induces immunosuppression when expressed in cultured neonatal mice keratinocytes.
Nengwen K, Li F, Li X, Juan S, Jianjun L, Chuntao Z, Youping L
Immunobiology. 2009
PubMed ID: 19249124
-
Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer.
Wang SS, Bratti MC, Rodríguez AC, Herrero R, Burk RD, Porras C, González P, Sherman ME, Wacholder S, Lan ZE, Schiffman M, Chanock SJ, Hildesheim A
J Infect Dis. 2009
PubMed ID: 19012493
-
Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation.
Yokosuka T, Kobayashi W, Sakata-Sogawa K, Takamatsu M, Hashimoto-Tane A, Dustin ML, Tokunaga M, Saito T
Immunity. 2008
PubMed ID: 18848472
-
Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells.
Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL
J Immunol. 2008
PubMed ID: 18832694
-
Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation.
Kim G, Turovskaya O, Levin M, Byrne FR, Whoriskey JS, McCabe JG, Kronenberg M
J Immunol. 2008
PubMed ID: 18832683
-
Evaluation of CD86/CD28 and CD40/CD154 pathways in regulating monocyte-derived CD80 expression during their interaction with allogeneic endothelium.
Wang P, Liu Z, Wu C, Zhu B, Wang Y, Xu H
Transplant Proc. 2008
PubMed ID: 18929847
-
[Efficiency of GHA priming chemotherapy on patients with refractory acute myeloid leukemia and myelodysplastic syndrome and its relationship with expression of costimulatory molecule B7.1].
Chen YX, Ma XR, Zhang WG, Liu J, Cao XM, He AL
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008
PubMed ID: 18928583
-
T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta.
Tseng SY, Waite JC, Liu M, Vardhana S, Dustin ML
J Immunol. 2008
PubMed ID: 18802089
-
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
-
Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation.
McPherson M, Wei B, Turovskaya O, Fujiwara D, Brewer S, Braun J
Am J Physiol Gastrointest Liver Physiol. 2008
PubMed ID: 18617557
-
Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus.
Duan B, Niu H, Xu Z, Sharpe AH, Croker BP, Sobel ES, Morel L
Lab Invest. 2008
PubMed ID: 18607347
-
CD28 controls differentiation of regulatory T cells from naive CD4 T cells.
Guo F, Iclozan C, Suh WK, Anasetti C, Yu XZ
J Immunol. 2008
PubMed ID: 18684917
-
Interaction of human PD-L1 and B7-1.
Butte MJ, Peña-Cruz V, Kim MJ, Freeman GJ, Sharpe AH
Mol Immunol. 2008
PubMed ID: 18585785
-
Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway.
Williams JA, Lumsden JM, Yu X, Feigenbaum L, Zhang J, Steinberg SM, Hodes RJ
J Immunol. 2008
PubMed ID: 18606642
-
HLA-G-treated tolerogenic dendritic cells induce tolerogenic potential by increasing expression of B7-1 (CD80) molecules.
Smith M, Bittner JG, White S, Smith D, Horuzsko A
Transplant Proc. 2008
PubMed ID: 18589158
-
Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells.
Shi Z, Rifa'i M, Lee YH, Shiku H, Isobe K, Suzuki H
Immunology. 2008
PubMed ID: 18205792
-
Expression of co-stimulatory molecules B7.1 & B7.2 on macrophages infected with various strains of Mycobacterium tuberculosis & its influence on T-cell apoptosis.
Rajavelu P, Das SD
Indian J Med Res. 2008
PubMed ID: 18577795
-
Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells.
Strainic MG, Liu J, Huang D, An F, Lalli PN, Muqim N, Shapiro VS, Dubyak GR, Heeger PS, Medof ME
Immunity. 2008
PubMed ID: 18328742
-
A critical role of costimulation during intrathymic development of invariant NK T cells.
Chung Y, Nurieva R, Esashi E, Wang YH, Zhou D, Gapin L, Dong C
J Immunol. 2008
PubMed ID: 18250436
-
CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis.
Nolan A, Weiden M, Kelly A, Hoshino Y, Hoshino S, Mehta N, Gold JA
Am J Respir Crit Care Med. 2008
PubMed ID: 17989345
-
Control of memory CD8+ T cell differentiation by CD80/CD86-CD28 costimulation and restoration by IL-2 during the recall response.
Fuse S, Zhang W, Usherwood EJ
J Immunol. 2008
PubMed ID: 18178855
-
Modulation of NKT cell development by B7-CD28 interaction: an expanding horizon for costimulation.
Zheng X, Zhang H, Yin L, Wang CR, Liu Y, Zheng P
PLoS ONE. 2008
PubMed ID: 18628995
-
Inhibitory B7 family members in human ovarian carcinoma.
Wei S, Curiel T, Coukos G, Liu R, Zou W
Adv Exp Med Biol. 2008
PubMed ID: 18546634
-
Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors.
Yamazaki S, Bonito AJ, Spisek R, Dhodapkar M, Inaba K, Steinman RM
Blood. 2007
PubMed ID: 17699744
-
Gene transfer of antisense B7.1 attenuates acute rejection against splenic allografts in rats.
Liu C, Pan S, Jiang H, Sun X
Transplant Proc. 2007
PubMed ID: 18089391
-
T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection.
Stephan MT, Ponomarev V, Brentjens RJ, Chang AH, Dobrenkov KV, Heller G, Sadelain M
Nat Med. 2007
PubMed ID: 18026115
-
Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells.
Habib-Agahi M, Phan TT, Searle PF
Int Immunol. 2007
PubMed ID: 17977894
-
Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression.
Ganesan PL, Alexander SI, Watson D, Logan GJ, Zhang GY, Alexander IE
Cancer Immunol Immunother. 2007
PubMed ID: 17549473
-
Memory CD8+ T cells require CD28 costimulation.
Borowski AB, Boesteanu AC, Mueller YM, Carafides C, Topham DJ, Altman JD, Jennings SR, Katsikis PD
J Immunol. 2007
PubMed ID: 17982038
-
Human Soluble CD80 is generated by alternative splicing, and recombinant soluble CD80 binds to CD28 and CD152 influencing T-cell activation.
Kakoulidou M, Giscombe R, Zhao X, Lefvert AK, Wang X
Scand J Immunol. 2007
PubMed ID: 17953528
-
Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro.
Dopheide JF, Sester U, Schlitt A, Horstick G, Rupprecht HJ, Münzel T, Blankenberg S
Coron Artery Dis. 2007
PubMed ID: 17925605
-
Expression of CD80/86 on B cells is essential for autoreactive T cell activation and the development of arthritis.
O'Neill SK, Cao Y, Hamel KM, Doodes PD, Hutas G, Finnegan A
J Immunol. 2007
PubMed ID: 17911596
-
Nonspecific CD4(+) T cells with uptake of antigen-specific dendritic cell-released exosomes stimulate antigen-specific CD8(+) CTL responses and long-term T cell memory.
Hao S, Yuan J, Xiang J
J Leukoc Biol. 2007
PubMed ID: 17626150
-
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B
J Infect Dis. 2007
PubMed ID: 17703412
-
Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase.
Shi M, Ye Z, Umeshappa KS, Moyana T, Xiang J
Biochem Biophys Res Commun. 2007
PubMed ID: 17618911
-
Role of CD80 and CD86 in host immune responses to the recombinant hemagglutinin domain of Porphyromonas gingivalis gingipain and in the adjuvanticity of cholera toxin B and monophosphoryl lipid A.
Zhang P, Lewis JP, Michalek SM, Katz J
Vaccine. 2007
PubMed ID: 17629367
-
Early changes in gene expression that influence the course of primary glomerular disease.
Clement LC, Liu G, Perez-Torres I, Kanwar YS, Avila-Casado C, Chugh SS
Kidney Int. 2007
PubMed ID: 17457373
-
Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.
Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ
Immunity. 2007
PubMed ID: 17629517
-
Blockade of the 4-1BB (CD137)/4-1BBL and/or CD28/CD80/CD86 costimulatory pathways promotes corneal allograft survival in mice.
Asai T, Choi BK, Kwon PM, Kim WY, Kim JD, Vinay DS, Gebhardt BM, Kwon BS
Immunology. 2007
PubMed ID: 17376197
-
[Expression of co-stimulatory molecules and role of interleukin 18 in peripheral lymphocytes of patients with idiopathic thrombocytopenic purpura]
Pan JL, Guan XR, Ma XH, He X
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007
PubMed ID: 17605869
-
The CD28/CTLA-4-B7 signaling pathway is involved in both allergic sensitization and tolerance induction to orally administered peanut proteins.
van Wijk F, Nierkens S, de Jong W, Wehrens EJ, Boon L, van Kooten P, Knippels LM, Pieters R
J Immunol. 2007
PubMed ID: 17513738
-
Paradoxical effect of reduced costimulation in T cell-mediated colitis.
Kim G, Levin M, Schoenberger SP, Sharpe A, Kronenberg M
J Immunol. 2007
PubMed ID: 17442938
-
Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease.
Chikuma S, Bluestone JA
Eur J Immunol. 2007
PubMed ID: 17429849
-
Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats.
Lai KW, Wei CL, Tan LK, Tan PH, Chiang GS, Lee CG, Jordan SC, Yap HK
J Am Soc Nephrol. 2007
PubMed ID: 17429054
-
ICOS and B7 costimulatory molecule expression identifies activated cellular subsets in rheumatoid arthritis.
Ruth JH, Rottman JB, Kingsbury GA, Coyle AJ, Haines GK, Pope RM, Koch AE
Cytometry A. 2007
PubMed ID: 17323353
-
Anti-B7-1/B7-2 antibody elicits innate-effector responses in macrophages through NF-kappaB-dependent pathway.
Khan N, Ghousunnissa S, Jegadeeswaran SM, Thiagarajan D, Hasnain SE, Mukhopadhyay S
Int Immunol. 2007
PubMed ID: 17314080
-
A two-pronged mechanism for HIV-1 Nef-mediated endocytosis of immune costimulatory molecules CD80 and CD86.
Chaudhry A, Das SR, Jameel S, George A, Bal V, Mayor S, Rath S
Cell Host Microbe. 2007
PubMed ID: 18005680
-
Induction of immunological antitumor effects by adenovirus-mediated gene transfer of B7-1 in a murine squamous cell carcinoma cell line.
Hoshitani Y, Ishida H, Otsuki N, Shirakawa T, Gotoh A, Nibu K
Arch Otolaryngol Head Neck Surg. 2007
PubMed ID: 17372085
-
B7-1 and 4-1BB ligand expression on a myeloma cell line makes it possible to expand autologous tumor-specific cytotoxic T cells in vitro.
Lu ZY, Condomines M, Tarte K, Nadal L, Delteil MC, Rossi JF, Ferrand C, Klein B
Exp Hematol. 2007
PubMed ID: 17309825
-
B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells.
May KF, Chang X, Zhang H, Lute KD, Zhou P, Kocak E, Zheng P, Liu Y
J Immunol. 2007
PubMed ID: 17237403
-
Chondrogenic differentiation alters the immunosuppressive property of bone marrow-derived mesenchymal stem cells, and the effect is partially due to the upregulated expression of B7 molecules.
Chen X, McClurg A, Zhou GQ, McCaigue M, Armstrong MA, Li G
Stem Cells. 2007
PubMed ID: 17068184
-
Differential contributions of B7-1 and B7-2 to the development of murine experimental allergic conjunctivitis.
Sumi T, Fukushima A, Fukuda K, Kumagai N, Nishida T, Yagita H, Ueno H
Immunol Lett. 2007
PubMed ID: 17109973
-
Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma.
Chang CS, Chang JH, Hsu NC, Lin HY, Chung CY
BMC Cancer. 2007
PubMed ID: 17524139
-
The net effect of costimulatory blockers is dependent on the subset and activation status of the autoreactive T cells.
Zhang P, Sun D, Ke Y, Kaplan HJ, Shao H
J Immunol. 2007
PubMed ID: 17182586
-
Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1.
Mintern JD, Klemm EJ, Wagner M, Paquet ME, Napier MD, Kim YM, Koszinowski UH, Ploegh HL
J Immunol. 2006
PubMed ID: 17142739
-
Differential requirement for CD28 and CD80/86 pathways of costimulation in the long-term control of murine gammaherpesvirus-68.
Lyon AB, Sarawar SR
Virology. 2006
PubMed ID: 16934307
-
B7+ iris pigment epithelial cells convert T cells into CTLA-4+, B7-expressing CD8+ regulatory T cells.
Sugita S, Keino H, Futagami Y, Takase H, Mochizuki M, Stein-Streilein J, Streilein JW
Invest Ophthalmol Vis Sci. 2006
PubMed ID: 17122127
-
Structure and duration of contact between dendritic cells and T cells are controlled by T cell activation state.
Rothoeft T, Balkow S, Krummen M, Beissert S, Varga G, Loser K, Oberbanscheidt P, van den Boom F, Grabbe S
Eur J Immunol. 2006
PubMed ID: 17111349
-
CD4(+) T cells stimulate memory CD8(+) T cell expansion via acquired pMHC I complexes and costimulatory molecules, and IL-2 secretion.
Shi M, Hao S, Chan T, Xiang J
J Leukoc Biol. 2006
PubMed ID: 16980510
-
Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors.
Short JJ, Vasu C, Holterman MJ, Curiel DT, Pereboev A
Virus Res. 2006
PubMed ID: 16920215
-
A negative regulatory role in mouse cardiac transplantation for a splice variant of CD80.
Bugeon L, Wong KK, Rankin AM, Hargreaves RE, Dallman MJ
Transplantation. 2006
PubMed ID: 17130783
-
Endogenous expression of CD80 co-stimulatory molecule facilitates in vivo tumor regression of oral squamous carcinoma.
Thomas GR, Wen J
Anticancer Res. 2006
PubMed ID: 17201120
-
The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS.
Quaranta MG, Mattioli B, Giordani L, Viora M
FASEB J. 2006
PubMed ID: 17077296
-
The mechanism of exogenous B7.1-enhanced IL-12-mediated complete regression of tumors by a single electroporation delivery.
Liu J, Xia X, Torrero M, Barrett R, Shillitoe EJ, Li S
Int J Cancer. 2006
PubMed ID: 16823840
-
CD80 and CD86 control antiviral CD8+ T-cell function and immune surveillance of murine gammaherpesvirus 68.
Fuse S, Obar JJ, Bellfy S, Leung EK, Zhang W, Usherwood EJ
J Virol. 2006
PubMed ID: 16940527
-
CD8+ cytotoxic T-APC stimulate central memory CD8+ T cell responses via acquired peptide-MHC class I complexes and CD80 costimulation, and IL-2 secretion.
Xia D, Hao S, Xiang J
J Immunol. 2006
PubMed ID: 16920933
-
CD4+ T cell expressed CD80 regulates central nervous system effector function and survival during experimental autoimmune encephalomyelitis.
Podojil JR, Kohm AP, Miller SD
J Immunol. 2006
PubMed ID: 16920930
-
Tumor cells with B7.1 and transmembrane anchored staphylococcal enterotoxin A generate effective antitumor immunity.
Si SY, Hu PZ, Huang YY, Ye J, Huang Y, Li ZS, Ge W, Li X, Qu P, Zhang XM, Sui YF
Biochem Biophys Res Commun. 2006
PubMed ID: 16814254
-
Intraperitoneal Echinococcus multilocularis infection in C57BL/6 mice affects CD40 and B7 costimulator expression on peritoneal macrophages and impairs peritoneal T cell activation.
Mejri N, Gottstein B
Parasite Immunol. 2006
PubMed ID: 16879309
-
Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation.
Watanabe R, Harada Y, Takeda K, Takahashi J, Ohnuki K, Ogawa S, Ohgai D, Kaibara N, Koiwai O, Tanabe K, Toma H, Sugamura K, Abe R
J Immunol. 2006
PubMed ID: 16818765
-
CD80 in immune suppression by mouse ovarian carcinoma-associated Gr-1+CD11b+ myeloid cells.
Yang R, Cai Z, Zhang Y, Yutzy WH, Roby KF, Roden RB
Cancer Res. 2006
PubMed ID: 16818658
-
[Clone and expression of murine BTLA extracellular domain gene and its effect on the expression of B7 on dendritic cells]
Xu JF, Zhao K, Huang BJ, Xiong P, Fang M, Shen GX, Gong FL
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2006
PubMed ID: 16805995
-
Purified neonatal plasmacytoid dendritic cells overcome intrinsic maturation defect with TLR agonist stimulation.
Gold MC, Donnelly E, Cook MS, Leclair CM, Lewinsohn DA
Pediatr Res. 2006
PubMed ID: 16690948
-
B7-1-HSA (CD80-CD24), a recombinant hybrid costimulatory molecule retains ligand binding and costimulatory functions.
Wang YC, Sashidharamurthy R, Nagarajan S, Selvaraj P
Immunol Lett. 2006
PubMed ID: 16621031
-
T-cell tolerance or function is determined by combinatorial costimulatory signals.
Nurieva R, Thomas S, Nguyen T, Martin-Orozco N, Wang Y, Kaja MK, Yu XZ, Dong C
EMBO J. 2006
PubMed ID: 16724117
-
Mycophenolic acid upregulates B7-DC expression on dendritic cells, which is associated with impaired allostimulatory capacity of dendritic cells.
Geng L, Jiang G, Xie H, Fang Y, Dong S, Chen Y, Shen M, Zheng S
Transplant Proc. 2006
PubMed ID: 16797370
-
Sustained B7/CD28 interactions and resultant phosphatidylinositol 3-kinase activity maintain G1-->S phase transitions at an optimal rate.
Bonnevier JL, Yarke CA, Mueller DL
Eur J Immunol. 2006
PubMed ID: 16703564
-
The DNA sequence, annotation and analysis of human chromosome 3.
Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA
Nature. 2006
PubMed ID: 16641997
-
Influence of local and systemic CTLA4Ig gene transfer on corneal allograft survival.
Gong N, Pleyer U, Yang J, Vogt K, Hill M, Anegon I, Volk HD, Ritter T
J Gene Med. 2006
PubMed ID: 16475216
-
Peritoneal macrophages suppress T-cell activation by amino acid catabolism.
Matlack R, Yeh K, Rosini L, Gonzalez D, Taylor J, Silberman D, Pennello A, Riggs J
Immunology. 2006
PubMed ID: 16476058
-
TLR2 and TLR4 differentially regulate B7-1 resulting in distinct cytokine responses to the mycoplasma superantigen MAM as well as to disease induced by Mycoplasma arthritidis.
Mu HH, Humphreys J, Chan FV, Cole BC
Cell Microbiol. 2006
PubMed ID: 16469054
-
Role of CD80 in stimulating T lymphocyte activation.
Li DC, Zhu XG, Zhang Y, Fu JX
World J Gastroenterol. 2006
PubMed ID: 16521215
-
Natural regulatory T cells control the development of atherosclerosis in mice.
Ait-Oufella H, Salomon BL, Potteaux S, Robertson AK, Gourdy P, Zoll J, Merval R, Esposito B, Cohen JL, Fisson S, Flavell RA, Hansson GK, Klatzmann D, Tedgui A, Mallat Z
Nat Med. 2006
PubMed ID: 16462800
-
Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism.
Montagnoli C, Fallarino F, Gaziano R, Bozza S, Bellocchio S, Zelante T, Kurup WP, Pitzurra L, Puccetti P, Romani L
J Immunol. 2006
PubMed ID: 16424201
-
Modelling thymic HIV-1 Nef effects.
Stove V, Verhasselt B
Curr HIV Res. 2006
PubMed ID: 16454711
-
CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse.
Tseng SY, Liu M, Dustin ML
J Immunol. 2005
PubMed ID: 16339518
-
Bone marrow-derived dendritic cells reverse the anergic state of CD4+CD25+ T cells without reversing their suppressive function.
Brinster C, Shevach EM
J Immunol. 2005
PubMed ID: 16301639
-
Functional analysis of HIV type 1 Nef reveals a role for PAK2 as a regulator of cell phenotype and function in the murine dendritic cell line, DC2.4.
Mann J, Patrick CN, Cragg MS, Honeychurch J, Mann DA, Harris M
J Immunol. 2005
PubMed ID: 16272310
-
Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells.
Krupnick AS, Gelman AE, Barchet W, Richardson S, Kreisel FH, Turka LA, Colonna M, Patterson GA, Kreisel D
J Immunol. 2005
PubMed ID: 16272276
-
CD80/CD86 costimulation regulates acute vascular rejection.
Hosiawa KA, Wang H, DeVries ME, Garcia B, Liu W, Zhou D, Akram A, Jiang J, Sun H, Cameron MJ, Zhong R, Kelvin DJ
J Immunol. 2005
PubMed ID: 16237117
-
Regulation of B7.1 costimulatory molecule is mediated by the IFN regulatory factor-7 through the activation of JNK in lipopolysaccharide-stimulated human monocytic cells.
Lim W, Gee K, Mishra S, Kumar A
J Immunol. 2005
PubMed ID: 16237059
-
Cutting edge: cytotoxic granule polarization and cytolysis can occur without central supramolecular activation cluster formation in CD8+ effector T cells.
O'Keefe JP, Gajewski TF
J Immunol. 2005
PubMed ID: 16237042
-
Different cell surface oligomeric states of B7-1 and B7-2: implications for signaling.
Bhatia S, Edidin M, Almo SC, Nathenson SG
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16221763
-
The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs.
Chaudhry A, Das SR, Hussain A, Mayor S, George A, Bal V, Jameel S, Rath S
J Immunol. 2005
PubMed ID: 16177101
-
B7 molecule mRNA expression in colorectal carcinoma.
Xiao JX, Bai PS, Lai BC, Li L, Zhu J, Wang YL
World J Gastroenterol. 2005
PubMed ID: 16237760
-
Differential requirement for CD28/CTLA-4-CD80/CD86 interactions in drug-induced type 1 and type 2 immune responses to trinitrophenyl-ovalbumin.
Nierkens S, Aalbers M, Bol M, Bleumink R, van Kooten P, Boon L, Pieters R
J Immunol. 2005
PubMed ID: 16148116
-
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
-
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
-
Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells.
Feuillet V, Lucas B, Di Santo JP, Bismuth G, Trautmann A
Eur J Immunol. 2005
PubMed ID: 16078277
-
CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms.
Odobasic D, Kitching AR, Tipping PG, Holdsworth SR
Kidney Int. 2005
PubMed ID: 16014035
-
Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c.
Chen Y, Perry D, Boackle SA, Sobel ES, Molina H, Croker BP, Morel L
J Immunol. 2005
PubMed ID: 16002709
-
Hierarchical regulation of CTLA-4 dimer-based lattice formation and its biological relevance for T cell inactivation.
Darlington PJ, Kirchhof MG, Criado G, Sondhi J, Madrenas J
J Immunol. 2005
PubMed ID: 16002699
-
Mechanisms of gene therapy for tolerance: B7 signaling is required for peptide-IgG gene-transferred tolerance induction.
Litzinger MT, Su Y, Lei TC, Soukhareva N, Scott DW
J Immunol. 2005
PubMed ID: 16002674
-
Human immunodeficiency virus type 1 Vpr impairs dendritic cell maturation and T-cell activation: implications for viral immune escape.
Majumder B, Janket ML, Schafer EA, Schaubert K, Huang XL, Kan-Mitchell J, Rinaldo CR, Ayyavoo V
J Virol. 2005
PubMed ID: 15956545
-
Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis.
Odobasic D, Kitching AR, Semple TJ, Timoshanko JR, Tipping PG, Holdsworth SR
J Am Soc Nephrol. 2005
PubMed ID: 15944341
-
CTLA4-CD80/CD86 interactions on primary mouse CD4+ T cells integrate signal-strength information to modulate activation with Concanavalin A.
Mukherjee S, Ahmed A, Nandi D
J Leukoc Biol. 2005
PubMed ID: 15788440
-
Signaling through CD40 ligand decreases CD80 expression on murine Langerhans cells and enhances IL-12 p40 production.
Sugaya M, Nakamura K, Asahina A, Fujita H, Tada Y, Torii H, Tamaki K
Biochem Biophys Res Commun. 2005
PubMed ID: 15882983
-
Abortive versus productive viral infection of dendritic cells with a paramyxovirus results in differential upregulation of select costimulatory molecules.
Pejawar SS, Parks GD, Alexander-Miller MA
J Virol. 2005
PubMed ID: 15919909
-
Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo.
Ito T, Ueno T, Clarkson MR, Yuan X, Jurewicz MM, Yagita H, Azuma M, Sharpe AH, Auchincloss H, Sayegh MH, Najafian N
J Immunol. 2005
PubMed ID: 15905503
-
Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis.
Handa T, Nagai S, Ito I, Tabuena R, Shigematsu M, Hamada K, Kitaichi M, Izumi T, Aoyama T, Toguchida J, Mishima M
Respiration. 2005
PubMed ID: 15942292
-
An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice.
Loser K, Scherer A, Krummen MB, Varga G, Higuchi T, Schwarz T, Sharpe AH, Grabbe S, Bluestone JA, Beissert S
J Immunol. 2005
PubMed ID: 15843526
-
Critical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviation.
Tsukahara R, Takeuchi M, Akiba H, Kezuka T, Takeda K, Usui Y, Usui M, Yagita H, Okumura K
Int Immunol. 2005
PubMed ID: 15778288
-
CD80 binding polyproline helical peptide inhibits T cell activation.
Srinivasan M, Lu D, Eri R, Brand DD, Haque A, Blum JS
J Biol Chem. 2005
PubMed ID: 15598660
-
Regulatory T cell lineage specification by the forkhead transcription factor foxp3.
Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY
Immunity. 2005
PubMed ID: 15780990
-
Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ.
Anderson BE, McNiff JM, Jain D, Blazar BR, Shlomchik WD, Shlomchik MJ
Blood. 2005
PubMed ID: 15522961
-
A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection.
Vacchio MS, Williams JA, Hodes RJ
Eur J Immunol. 2005
PubMed ID: 15657954
-
HIV-1 Vpr inhibits the maturation and activation of macrophages and dendritic cells in vitro.
Muthumani K, Hwang DS, Choo AY, Mayilvahanan S, Dayes NS, Thieu KP, Weiner DB
Int Immunol. 2005
PubMed ID: 15611322
-
Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus.
Liang S, Alard P, Zhao Y, Parnell S, Clark SL, Kosiewicz MM
J Exp Med. 2005
PubMed ID: 15630140
-
CD80, but not CD86, express on cultured murine keratinocyte stem cells.
Lei J, Cheng J, Li Y, Li S, Zhang L
Transplant Proc. 2005
PubMed ID: 15808622
-
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
-
B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator.
Sedy JR, Gavrieli M, Potter KG, Hurchla MA, Lindsley RC, Hildner K, Scheu S, Pfeffer K, Ware CF, Murphy TL, Murphy KM
Nat Immunol. 2005
PubMed ID: 15568026
-
High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy.
Huxley P, Sutton DH, Debnam P, Matthews IR, Brewer JE, Rose J, Trickett M, Williams DD, Andersen TB, Classon BJ
Chem Biol. 2004
PubMed ID: 15610849
-
The role of costimulatory molecules CD80 and CD86 and IFNgamma in the pathogenesis of ulcerative colitis.
Scarpa M, Behboo R, Angriman I, Termini B, Barollo M, Ruffolo C, Polese L, D'Incà R, Sturniolo GC, D'Amico DF
Dig Dis Sci. 2004
PubMed ID: 15628695
-
Up-regulation of CD80-CD86 and IgA on mouse peritoneal B-1 cells by porin of Shigella dysenteriae is Toll-like receptors 2 and 6 dependent.
Ray A, Karmakar P, Biswas T
Mol Immunol. 2004
PubMed ID: 15482852
-
Role of B7 in T cell tolerance.
Lohr J, Knoechel B, Kahn EC, Abbas AK
J Immunol. 2004
PubMed ID: 15470046
-
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
-
Role of B7 costimulatory molecules in mediating systemic and mucosal antibody responses to attenuated Salmonella enterica serovar Typhimurium and its cloned antigen.
Garcia CA, Martin M, Michalek SM
Infect Immun. 2004
PubMed ID: 15385483
-
Decreased expression of B7 costimulatory molecules and major histocompatibility complex class-I in human hepatocellular carcinoma.
Fujiwara K, Higashi T, Nouso K, Nakatsukasa H, Kobayashi Y, Uemura M, Nakamura S, Sato S, Hanafusa T, Yumoto Y, Naito I, Shiratori Y
J Gastroenterol Hepatol. 2004
PubMed ID: 15377288
-
In a model of tumor dormancy, long-term persistent leukemic cells have increased B7-H1 and B7.1 expression and resist CTL-mediated lysis.
Saudemont A, Quesnel B
Blood. 2004
PubMed ID: 15191948
-
A role for CD28 in lymphopenia-induced proliferation of CD4 T cells.
Hagen KA, Moses CT, Drasler EF, Podetz-Pedersen KM, Jameson SC, Khoruts A
J Immunol. 2004
PubMed ID: 15356139
-
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S
Genome Res. 2004
PubMed ID: 15342556
-
CD24 controls expansion and persistence of autoreactive T cells in the central nervous system during experimental autoimmune encephalomyelitis.
Bai XF, Li O, Zhou Q, Zhang H, Joshi PS, Zheng X, Liu Y, Wang Y, Zheng P, Liu Y
J Exp Med. 2004
PubMed ID: 15314074
-
Role of caspase in CD80 expression of superantigen-stimulated monocytes.
Shinohara F, Sato K, Suzuki M, Takada H, Echigo S, Rikiishi H
Int J Mol Med. 2004
PubMed ID: 15254772
-
CD80 transfected human hepatocellular carcinoma cells activate cytotoxic T lymphocytes to target HCC cells with shared tumor antigens.
Chan RC, Xie Y
Oncol Rep. 2004
PubMed ID: 15254713
-
CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development.
McKee AS, Pearce EJ
J Immunol. 2004
PubMed ID: 15240714
-
Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease.
Paust S, Lu L, McCarty N, Cantor H
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15235129
-
Tumor necrosis factor-alpha and CD80 modulate CD28 expression through a similar mechanism of T-cell receptor-independent inhibition of transcription.
Lewis DE, Merched-Sauvage M, Goronzy JJ, Weyand CM, Vallejo AN
J Biol Chem. 2004
PubMed ID: 15128741
-
Suppression of peritoneal metastasis in human gastric carcinoma by enhanced immunogenicity of B7-1 transfection.
Sakate Y, Yashiro M, Tanaka H, Kosaka K, Ohira M, Hirakawa K
Oncol Rep. 2004
PubMed ID: 15201958
-
The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation.
Fujii S, Liu K, Smith C, Bonito AJ, Steinman RM
J Exp Med. 2004
PubMed ID: 15197224
-
Insertion of host-derived costimulatory molecules CD80 (B7.1) and CD86 (B7.2) into human immunodeficiency virus type 1 affects the virus life cycle.
Giguère JF, Bounou S, Paquette JS, Madrenas J, Tremblay MJ
J Virol. 2004
PubMed ID: 15163715
-
Induction of B7-1 in podocytes is associated with nephrotic syndrome.
Reiser J, von Gersdorff G, Loos M, Oh J, Asanuma K, Giardino L, Rastaldi MP, Calvaresi N, Watanabe H, Schwarz K, Faul C, Kretzler M, Davidson A, Sugimoto H, Kalluri R, Sharpe AH, Kreidberg JA, Mundel P
J Clin Invest. 2004
PubMed ID: 15146236
-
Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors.
Short JJ, Pereboev AV, Kawakami Y, Vasu C, Holterman MJ, Curiel DT
Virology. 2004
PubMed ID: 15110532
-
Cross-regulation of CD86 by CD80 differentially regulates T helper responses from Mycobacterium tuberculosis secretory antigen-activated dendritic cell subsets.
Balkhi MY, Latchumanan VK, Singh B, Sharma P, Natarajan K
J Leukoc Biol. 2004
PubMed ID: 14966193
-
Genetic variations in humans associated with differences in the course of hepatitis C.
Saito T, Ji G, Shinzawa H, Okumoto K, Hattori E, Adachi T, Takeda T, Sugahara K, Ito JI, Watanabe H, Saito K, Togashi H, Ishii K, Matsuura T, Inageda K, Muramatsu M, Kawata S
Biochem Biophys Res Commun. 2004
PubMed ID: 15063762
-
B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice.
Buono C, Pang H, Uchida Y, Libby P, Sharpe AH, Lichtman AH
Circulation. 2004
PubMed ID: 15096453
-
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
Genome Res. 2004
PubMed ID: 15060019
-
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
-
CTLA-4+CD8+ T cells that encounter B7-2+ iris pigment epithelial cells express their own B7-2 to achieve global suppression of T cell activation.
Sugita S, Ng TF, Schwartzkopff J, Streilein JW
J Immunol. 2004
PubMed ID: 15034031
-
Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells.
Munn DH, Sharma MD, Mellor AL
J Immunol. 2004
PubMed ID: 15034022
-
The role of B7 molecules in the cell contact-mediated suppression of T cell mitogenesis by immunosuppressive macrophages induced with mycobacterial infection.
Shimizu T, Sano C, Tomioka H
Clin Exp Immunol. 2004
PubMed ID: 15008968
-
CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells.
Zheng Y, Manzotti CN, Liu M, Burke F, Mead KI, Sansom DM
J Immunol. 2004
PubMed ID: 14978077
-
Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients.
Teutsch SM, Booth DR, Bennetts BH, Heard RN, Stewart GJ
J Neuroimmunol. 2004
PubMed ID: 14975605
-
Clinical significance of costimulatory molecules CD80/CD86 expression in IgA nephropathy.
Wu Q, Jinde K, Endoh M, Sakai H
Kidney Int. 2004
PubMed ID: 14871408
-
Role of B7 costimulatory molecules in immune responses and T-helper cell differentiation in response to recombinant HagB from Porphyromonas gingivalis.
Zhang P, Martin M, Yang QB, Michalek SM, Katz J
Infect Immun. 2004
PubMed ID: 14742503
-
The role of B7 ligands (CD80 and CD86) in CD152-mediated allograft tolerance: a crosscheck hypothesis.
Tsai MK, Ho HN, Chien HF, Ou-Yang P, Lee CJ, Lee PH
Transplantation. 2004
PubMed ID: 14724434
-
Detection of the impairment of CD80 expression on circulating monocytes in HIV-infected Thai children.
Ubol S, Aiamkitsumrit B, Nitayaphan S, Sirinavin S, Kitthawee S
Microbiol Immunol. 2004
PubMed ID: 15272203
-
B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections].
Taylor PA, Lees CJ, Fournier S, Allison JP, Sharpe AH, Blazar BR
J Immunol. 2004
PubMed ID: 14688306
-
Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells.
Gao JX, Liu X, Wen J, Caligiuri MA, Stroynowski I, Zheng P, Liu Y
Blood. 2003
PubMed ID: 12933569
-
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
-
Role of nod2 in the response of macrophages to toll-like receptor agonists.
Pauleau AL, Murray PJ
Mol Cell Biol. 2003
PubMed ID: 14560001
-
Costimulatory molecule immune enhancement in a plasmid vaccine model is regulated in part through the Ig constant-like domain of CD80/86.
Agadjanyan MG, Chattergoon MA, Holterman MJ, Monzavi-Karbassi B, Kim JJ, Dentchev T, Wilson D, Ayyavoo V, Montaner LJ, Kieber-Emmons T, Sekaly RP, Weiner DB
J Immunol. 2003
PubMed ID: 14530356
-
CD80, but not CD86 were up-regulated on the spleen-derived dendritic cells from OVA-sensitized and challenged BALB/c mice.
Cheng X, Wang C, Qian G, Zhu B
Immunol Lett. 2003
PubMed ID: 12946862
-
Dendritic cell uptake of human apoptotic and necrotic neutrophils inhibits CD40, CD80, and CD86 expression and reduces allogeneic T cell responses: relevance to systemic vasculitis.
Clayton AR, Prue RL, Harper L, Drayson MT, Savage CO
Arthritis Rheum. 2003
PubMed ID: 12905492
-
Augmentation of B7 expression by herpes simplex virus antigen.
Singh R, Kumar A, Diaz-Mitoma F
Hum Immunol. 2003
PubMed ID: 12878356
-
BCL6 controls the expression of the B7-1/CD80 costimulatory receptor in germinal center B cells.
Niu H, Cattoretti G, Dalla-Favera R
J Exp Med. 2003
PubMed ID: 12860928
-
Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor.
Shin T, Kennedy G, Gorski K, Tsuchiya H, Koseki H, Azuma M, Yagita H, Chen L, Powell J, Pardoll D, Housseau F
J Exp Med. 2003
PubMed ID: 12847135
-
Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4.
Sugita S, Streilein JW
J Exp Med. 2003
PubMed ID: 12835481
-
Effect of prostaglandin E2 on intercellular adhesion molecule-1 and B7 expression in mixed lymphocyte reaction.
Morichika T, Takahashi HK, Iwagaki H, Yagi T, Saito S, Kubo S, Yoshino T, Akagi T, Mori S, Nishibori M, Tanaka N
Transplantation. 2003
PubMed ID: 12829919
-
Cross-species costimulation: relative contributions of CD80, CD86, and CD40.
Rogers NJ, Jackson IM, Jordan WJ, Hawadle MA, Dorling A, Lechler RI
Transplantation. 2003
PubMed ID: 12829914
-
In situ expression and significance of B7 costimulatory molecules within tissues of human gastric carcinoma.
Chen XL, Cao XD, Kang AJ, Wang KM, Su BS, Wang YL
World J Gastroenterol. 2003
PubMed ID: 12800259
-
A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
Buhlmann JE, Elkin SK, Sharpe AH
J Immunol. 2003
PubMed ID: 12759417
-
B7-1 costimulatory molecule is critical for the development of experimental autoimmune myasthenia gravis.
Poussin MA, Tüzün E, Goluszko E, Scott BG, Yang H, Franco JU, Christadoss P
J Immunol. 2003
PubMed ID: 12682276
-
The role of PI3K in immune cells.
Koyasu S
Nat Immunol. 2003
PubMed ID: 12660731
-
Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling.
Zhang X, Schwartz JC, Almo SC, Nathenson SG
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12606712
-
A recombinant vector expressing transgenes for four T-cell costimulatory molecules (OX40L, B7-1, ICAM-1, LFA-3) induces sustained CD4+ and CD8+ T-cell activation, protection from apoptosis, and enhanced cytokine production.
Grosenbach DW, Schlom J, Gritz L, Gómez Yafal A, Hodge JW
Cell Immunol. 2003
PubMed ID: 12798307
-
Melphalan-induced up-regulation of B7-1 surface expression on normal splenic B cells.
Donepudi M, Jovasevic VM, Raychaudhuri P, Mokyr MB
Cancer Immunol Immunother. 2003
PubMed ID: 12649745
-
Upregulation of B7 molecules (CD80 and CD86) and exacerbated eosinophilic pulmonary inflammatory response in mice lacking the IFN-beta gene.
Matheu V, Treschow A, Navikas V, Issazadeh-Navikas S
J Allergy Clin Immunol. 2003
PubMed ID: 12642836
-
On the biological relevance of MHC class II and B7 expression by tumour cells in melanoma metastases.
Bernsen MR, Håkansson L, Gustafsson B, Krysander L, Rettrup B, Ruiter D, Håkansson A
Br J Cancer. 2003
PubMed ID: 12569387
-
Differential requirements for expression of CD80/86 and CD40 on B cells for T-dependent antibody responses in vivo.
Lumsden JM, Williams JA, Hodes RJ
J Immunol. 2003
PubMed ID: 12517941
-
CD80 and CD86 expression on LPS-stimulated monocytes and the effect of CD80 and CD86 blockade on IL-4 and IFN-gamma production in nonatopic bronchial asthma.
Rutkowski R, Moniuszko T, Stasiak-Barmuta A, Kosztyła-Hojna B, Alifier M, Rutkowski K, Tatarczuk-Krawiel A
Arch Immunol Ther Exp (Warsz). 2003
PubMed ID: 14692664
-
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
-
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
-
[The identical effects of B7-1 and B7-2 on regulation of human IL-2 gene transcription factors NF-kappa B and AP-1]
Ke XY, Gribben J, Wang J, Wang DB
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2002
PubMed ID: 12513711
-
B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans.
Montagnoli C, Bacci A, Bozza S, Gaziano R, Mosci P, Sharpe AH, Romani L
J Immunol. 2002
PubMed ID: 12444136
-
Acquisition of CD80 by human T cells at early stages of activation: functional involvement of CD80 acquisition in T cell to T cell interaction.
Tatari-Calderone Z, Semnani RT, Nutman TB, Schlom J, Sabzevari H
J Immunol. 2002
PubMed ID: 12444120
-
Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashion.
Kreisel D, Krupnick AS, Balsara KR, Riha M, Gelman AE, Popma SH, Szeto WY, Turka LA, Rosengard BR
J Immunol. 2002
PubMed ID: 12444119
-
Expression of B7 molecules in the eye during experimental autoimmune anterior uveitis (EAAU).
Shao H, Sun D, Sun SL, Cruze JM, Bora N, Kaplan HJ
Curr Eye Res. 2002
PubMed ID: 12658546
-
Role of CD80, CD86, and CTLA4 on mouse CD4(+) T lymphocytes in enhancing cell-cycle progression and survival after activation with PMA and ionomycin.
Mukherjee S, Maiti PK, Nandi D
J Leukoc Biol. 2002
PubMed ID: 12429713
-
Cutting edge: a crucial role for B7-CD28 in transmitting T help from APC to CTL.
Prilliman KR, Lemmens EE, Palioungas G, Wolfe TG, Allison JP, Sharpe AH, Schoenberger SP
J Immunol. 2002
PubMed ID: 12370335
-
Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells.
Manzotti CN, Tipping H, Perry LC, Mead KI, Blair PJ, Zheng Y, Sansom DM
Eur J Immunol. 2002
PubMed ID: 12355442
-
Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice.
Schneider H, Mandelbrot DA, Greenwald RJ, Ng F, Lechler R, Sharpe AH, Rudd CE
J Immunol. 2002
PubMed ID: 12244135
-
Mice deficient in perforin, CD4+ T cells, or CD28-mediated signaling maintain the typical immunodominance hierarchies of CD8+ T-cell responses to influenza virus.
Chen W, Bennink JR, Morton PA, Yewdell JW
J Virol. 2002
PubMed ID: 12239309
-
B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in mice.
Akiyama Y, Shirasugi N, Uchida N, Matsumoto K, Kitajima M, Bashuda H, Yagita H, Okumura K, Aramaki O, Niimi M
Transplantation. 2002
PubMed ID: 12352894
-
CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis.
Mencacci A, Montagnoli C, Bacci A, Cenci E, Pitzurra L, Spreca A, Kopf M, Sharpe AH, Romani L
J Immunol. 2002
PubMed ID: 12218136
-
Cutting edge: the relative distribution of T cells responding to chemically dominant or minor epitopes of lysozyme is not affected by CD40-CD40 ligand and B7-CD28-CTLA-4 costimulatory pathways.
DiPaolo RJ, Unanue ER
J Immunol. 2002
PubMed ID: 12218093
-
Antibodies to B7.1 define the GFCC'C" face of the N-terminal domain as critical for co-stimulatory interactions.
Wang S, Veldman GM, Stahl M, Xing Y, Tobin JF, Erbe DV
Immunol Lett. 2002
PubMed ID: 12067755
-
Genetic background determines the requirement for B7 costimulation in induction of autoimmunity.
Jabs C, Greve B, Chang TT, Sobel RA, Sharpe AH, Kuchroo VK
Eur J Immunol. 2002
PubMed ID: 12207354
-
Role of B7 costimulatory molecules in the adjuvant activity of the heat-labile enterotoxin of Escherichia coli.
Martin M, Sharpe A, Clements JD, Michalek SM
J Immunol. 2002
PubMed ID: 12165495
-
Differential involvement of CD40, CD80, and major histocompatibility complex class I molecules in cytotoxicity induction and interferon-gamma production by human natural killer effectors.
Terrazzano G, Zanzi D, Palomba C, Carbone E, Grimaldi S, Pisanti S, Fontana S, Zappacosta S, Ruggiero G
J Leukoc Biol. 2002
PubMed ID: 12149421
-
Human neutrophil-expressed CD28 interacts with macrophage B7 to induce phosphatidylinositol 3-kinase-dependent IFN-gamma secretion and restriction of Leishmania growth.
Venuprasad K, Banerjee PP, Chattopadhyay S, Sharma S, Pal S, Parab PB, Mitra D, Saha B
J Immunol. 2002
PubMed ID: 12097397
-
In vivo immunogenicity of osteosarcoma cells that express B7-1a, an alternatively spliced form of B7-1.
Nagamori M, Kawaguchi S, Murakami M, Wada T, Inobe M, Ishii S, Uede T
Anticancer Res. 2002
PubMed ID: 12174878
-
Expansion of CD5 - B cells in multiple sclerosis correlates with CD80 (B7-1) expression.
Sellebjerg F, Jensen J, Jensen CV, Wiik A
Scand J Immunol. 2002
PubMed ID: 12100477
-
Endotoxin-induced gamma interferon production: contributing cell types and key regulatory factors.
Varma TK, Lin CY, Toliver-Kinsky TE, Sherwood ER
Clin Diagn Lab Immunol. 2002
PubMed ID: 11986256
-
Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells.
Gao JX, Zhang H, Bai XF, Wen J, Zheng X, Liu J, Zheng P, Liu Y
J Exp Med. 2002
PubMed ID: 11956287
-
In vivo CD86 blockade inhibits CD4+ T cell activation, whereas CD80 blockade potentiates CD8+ T cell activation and CTL effector function.
Lang TJ, Nguyen P, Peach R, Gause WC, Via CS
J Immunol. 2002
PubMed ID: 11937530
-
B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo.
Bai XF, Liu J, May KF, Guo Y, Zheng P, Liu Y
Blood. 2002
PubMed ID: 11929778
-
CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes.
Williams JA, Sharrow SO, Adams AJ, Hodes RJ
J Immunol. 2002
PubMed ID: 11884443
-
Differential effect of CD28 versus B7 blockade on direct pathway of allorecognition and self-restricted responses.
Haspot F, Villemain F, Laflamme G, Coulon F, Olive D, Tiollier J, Soulillou JP, Vanhove B
Blood. 2002
PubMed ID: 11877302
-
Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1+, but not B7-2+, murine myelogenous leukemia.
LaBelle JL, Hanke CA, Blazar BR, Truitt RL
Blood. 2002
PubMed ID: 11877291
-
Distinct role of CD80 and CD86 in the regulation of the activation of B cell and B cell lymphoma.
Suvas S, Singh V, Sahdev S, Vohra H, Agrewala JN
J Biol Chem. 2002
PubMed ID: 11726649
-
CD80 (B7-1) and CD86 (B7-2) are functionally equivalent in the initiation and maintenance of CD4+ T-cell proliferation after activation with suboptimal doses of PHA.
Vasilevko V, Ghochikyan A, Holterman MJ, Agadjanyan MG
DNA Cell Biol. 2002
PubMed ID: 12015893
-
Different intrathyroid expression of intercellular adhesion molecule-1 (ICAM-1) in Hashimoto's thyroiditis and Graves' disease: analysis at mRNA level and association with B7.1 costimulatory molecule.
Pesce G, Fiorino N, Riccio AM, Montagna P, Torre G, Salmaso C, Altrinetti V, Bagnasco M
J Endocrinol Invest. 2002
PubMed ID: 11936473
-
Small molecule ligands define a binding site on the immune regulatory protein B7.1.
Erbe DV, Wang S, Xing Y, Tobin JF
J Biol Chem. 2002
PubMed ID: 11741888
-
Simultaneous expression of allogenic class II MHC and B7.1 (CD80) molecules in A20 B-lymphoma cell line enhances tumor immunogenicity.
Jang YJ, Nam SY, Kim MS, Seong RH, Park YS, Chung YH, Chung HY
Mol Cells. 2002
PubMed ID: 11911464
-
Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses.
Tzachanis D, Berezovskaya A, Nadler LM, Boussiotis VA
Blood. 2002
PubMed ID: 11830501
-
CTLA-4 regulates cell cycle progression during a primary immune response.
Greenwald RJ, Oosterwegel MA, van der Woude D, Kubal A, Mandelbrot DA, Boussiotis VA, Sharpe AH
Eur J Immunol. 2002
PubMed ID: 11807776
-
B7-1 (CD80) and B7-2 (CD 86) expression in human tubular epithelial cells in vivo and in vitro.
Niemann-Masanek U, Mueller A, Yard BA, Waldherr R, van der Woude FJ
Nephron. 2002
PubMed ID: 12372936
-
Differential effects of iron deficiency on the expression of CD80 and CD86 co-stimulatory receptors in mitogen-treated and untreated murine spleen cells.
Kuvibidila SR, Porretta C
J Cell Biochem. 2002
PubMed ID: 12210763
-
Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses.
Fanales-Belasio E, Moretti S, Nappi F, Barillari G, Micheletti F, Cafaro A, Ensoli B
J Immunol. 2002
PubMed ID: 11751963
-
B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.
Mandelbrot DA, Oosterwegel MA, Shimizu K, Yamada A, Freeman GJ, Mitchell RN, Sayegh MH, Sharpe AH
J Clin Invest. 2001
PubMed ID: 11285307
-
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.
Stamper CC, Zhang Y, Tobin JF, Erbe DV, Ikemizu S, Davis SJ, Stahl ML, Seehra J, Somers WS, Mosyak L
Nature. 2001
PubMed ID: 11279502
-
Acquisition of CD80 (B7-1) by T cells.
Sabzevari H, Kantor J, Jaigirdar A, Tagaya Y, Naramura M, Hodge J, Bernon J, Schlom J
J Immunol. 2001
PubMed ID: 11160311
-
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
-
HLA class I molecule expression is up-regulated during maturation of dendritic cells, protecting them from natural killer cell-mediated lysis.
Ferlazzo G, Semino C, Melioli G
Immunol Lett. 2001
PubMed ID: 11222911
-
Mast cells as initiators of immunity and host defense.
Henz BM, Maurer M, Lippert U, Worm M, Babina M
Exp Dermatol. 2001
PubMed ID: 11168574
-
Expression of HLA-DR, CAM and co-stimulatory molecules on cord blood monocytes.
Varis I, Deneys V, Mazzon A, De Bruyere M, Cornu G, Brichard B
Eur J Haematol. 2001
PubMed ID: 11168518
-
Expression and function of the costimulatory molecules B7-1 (CD80) and B7-2 (CD86) in an in vitro model of the human blood--brain barrier.
Omari KI, Dorovini-Zis K
J Neuroimmunol. 2001
PubMed ID: 11137584
-
Selective silencing of full-length CD80 but not IgV-CD80 leads to impaired clonal deletion of self-reactive T cells and altered regulation of immune responses.
Bugeon L, Hargreaves RE, Crompton T, Outram S, Rahemtulla A, Porter AC, Dallman MJ
Eur J Immunol. 2001
PubMed ID: 11169445
-
M cell pockets of human Peyer's patches are specialized extensions of germinal centers.
Yamanaka T, Straumfors A, Morton H, Fausa O, Brandtzaeg P, Farstad I
Eur J Immunol. 2001
PubMed ID: 11169444
-
Bi-directional activation between human airway smooth muscle cells and T lymphocytes: role in induction of altered airway responsiveness.
Hakonarson H, Kim C, Whelan R, Campbell D, Grunstein MM
J Immunol. 2001
PubMed ID: 11123305
-
Functional equivalency of B7-1 and B7-2 for costimulating plasmid DNA vaccine-elicited CTL responses.
Santra S, Barouch DH, Jackson SS, Kuroda MJ, Schmitz JE, Lifton MA, Sharpe AH, Letvin NL
J Immunol. 2000
PubMed ID: 11120800
-
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, Fitz LJ, Malenkovich N, Okazaki T, Byrne MC, Horton HF, Fouser L, Carter L, Ling V, Bowman MR, Carreno BM, Collins M, Wood CR, Honjo T
J Exp Med. 2000
PubMed ID: 11015443
-
New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus.
Matsushita M, Tsuchiya N, Oka T, Yamane A, Tokunaga K
Genes Immun. 2000
PubMed ID: 11196673
-
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
-
Molecular cloning of the cDNAs encoding the feline B-lymphocyte activation antigen B7-1 (CD80) and B7-2 (CD86) homologues which interact with human CTLA4-Ig.
Nishimura Y, Shimojima M, Miyazawa T, Sato E, Nakamura K, Izumiya Y, Ikeda Y, Mikami T, Takahashi E
Eur J Immunogenet. 2000
PubMed ID: 11029611
-
Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus.
Liang B, Kashgarian MJ, Sharpe AH, Mamula MJ
J Immunol. 2000
PubMed ID: 10975864
-
Costimulatory molecules expression and cytokine profiles of cord blood mononuclear cells in newborns with low and high risk of developing atopic diseases.
Yang YH, Chen MC, Tsai MJ, Lin YT, Chiang BL
J Microbiol Immunol Infect. 2000
PubMed ID: 11045378
-
Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Faslpr mice.
Kinoshita K, Tesch G, Schwarting A, Maron R, Sharpe AH, Kelley VR
J Immunol. 2000
PubMed ID: 10820290
-
Regulatory role of mature B cells in a murine model of inflammatory bowel disease.
Mizoguchi E, Mizoguchi A, Preffer FI, Bhan AK
Int Immunol. 2000
PubMed ID: 10784605
-
Widespread expression of tartrate-resistant acid phosphatase (Acp 5) in the mouse embryo.
Hayman AR, Bune AJ, Cox TM
J Anat. 2000
PubMed ID: 10853965
-
Local control of the immune response in the liver.
Knolle PA, Gerken G
Immunol Rev. 2000
PubMed ID: 10807504
-
The role of B7 costimulation in CD4/CD8 T cell homeostasis.
Yu X, Fournier S, Allison JP, Sharpe AH, Hodes RJ
J Immunol. 2000
PubMed ID: 10725709
-
B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness.
Mark DA, Donovan CE, De Sanctis GT, He HZ, Cernadas M, Kobzik L, Perkins DL, Sharpe A, Finn PW
Am J Respir Cell Mol Biol. 2000
PubMed ID: 10696062
-
Structure and dimerization of a soluble form of B7-1.
Ikemizu S, Gilbert RJ, Fennelly JA, Collins AV, Harlos K, Jones EY, Stuart DI, Davis SJ
Immunity. 2000
PubMed ID: 10661405
-
Differential requirement for CD80 and CD80/CD86-dependent costimulation in the lung immune response to an influenza virus infection.
Lumsden JM, Roberts JM, Harris NL, Peach RJ, Ronchese F
J Immunol. 2000
PubMed ID: 10604996
-
B7 costimulation is critical for antibody class switching and CD8(+) cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus.
McAdam AJ, Farkash EA, Gewurz BE, Sharpe AH
J Virol. 2000
PubMed ID: 10590107
-
New forms of dog CD80 and CD86 transcripts that encode secreted B7 molecules.
Yang S, Sim GK
Immunogenetics. 1999
PubMed ID: 10630300
-
Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts.
Mandelbrot DA, Furukawa Y, McAdam AJ, Alexander SI, Libby P, Mitchell RN, Sharpe AH
J Immunol. 1999
PubMed ID: 10490971
-
Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis.
Chang TT, Jabs C, Sobel RA, Kuchroo VK, Sharpe AH
J Exp Med. 1999
PubMed ID: 10477557
-
Structure and chromosomal location of mouse and human CD52 genes.
Tone M, Nolan KF, Walsh LA, Tone Y, Thompson SA, Waldmann H
Biochim Biophys Acta. 1999
PubMed ID: 10524207
-
The role of CTLA-4 in regulating Th2 differentiation.
Oosterwegel MA, Mandelbrot DA, Boyd SD, Lorsbach RB, Jarrett DY, Abbas AK, Sharpe AH
J Immunol. 1999
PubMed ID: 10453003
-
B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies.
Liang B, Gee RJ, Kashgarian MJ, Sharpe AH, Mamula MJ
J Immunol. 1999
PubMed ID: 10438978
-
Ectopic expression of B7-1 (CD80) on T lymphocytes in autoimmune lpr and gld mice.
Weintraub JP, Cohen PL
Clin Immunol. 1999
PubMed ID: 10370375
-
Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: reversal of elicited T cell cytokine profile and partial inhibition of egg granuloma formation.
Hernandez HJ, Sharpe AH, Stadecker MJ
J Immunol. 1999
PubMed ID: 10072537
-
CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28.
Slavik JM, Hutchcroft JE, Bierer BE
J Biol Chem. 1999
PubMed ID: 9915850
-
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
-
Regression of intracerebral rat glioma isografts by therapeutic subcutaneous immunization with interferon-gamma, interleukin-7, or B7-1-transfected tumor cells.
Visse E, Siesjö P, Widegren B, Sjögren HO
Cancer Gene Ther. 1999
PubMed ID: 10078962
-
Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production.
Schweitzer AN, Sharpe AH
J Immunol. 1998
PubMed ID: 9743334
-
Gamma-ray irradiation induces B7.1 costimulatory molecule neoexpression in various murine tumor cells.
Morel A, Fernandez N, de La Coste A, Haddada H, Viguier M, Polla BS, Antoine B, Kahn A
Cancer Immunol Immunother. 1998
PubMed ID: 9690456
-
Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice.
Detmar M, Brown LF, Schön MP, Elicker BM, Velasco P, Richard L, Fukumura D, Monsky W, Claffey KP, Jain RK
J Invest Dermatol. 1998
PubMed ID: 9665379
-
Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice.
Gärdby E, Lane P, Lycke NY
J Immunol. 1998
PubMed ID: 9647206
-
B7-CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge.
Zheng P, Wu Y, Guo Y, Lee C, Liu Y
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9600957
-
Characterization of the altered cutaneous reactivity of transgenic mice whose keratinocytes overexpress B7-1.
Gaspari AA, Burns RP, Kondo S, Nasir A, Kurup A, Mlodynia D, Sauder D, Barth RK
Clin Immunol Immunopathol. 1998
PubMed ID: 9557159
-
Gene immunotherapy in murine acute myeloid leukemia: granulocyte-macrophage colony-stimulating factor tumor cell vaccines elicit more potent antitumor immunity compared with B7 family and other cytokine vaccines.
Dunussi-Joannopoulos K, Dranoff G, Weinstein HJ, Ferrara JL, Bierer BE, Croop JM
Blood. 1998
PubMed ID: 9414288
-
Interleukin-12-activated natural killer cells recognize B7 costimulatory molecules on tumor cells and autologous dendritic cells.
Geldhof AB, Moser M, Lespagnard L, Thielemans K, De Baetselier P
Blood. 1998
PubMed ID: 9414285
-
Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice.
Van Parijs L, Sethna MP, Schweitzer AN, Borriello F, Sharpe AH, Abbas AK
J Immunol. 1997
PubMed ID: 9548473
-
Regulation of self-tolerance by CD80/CD86 interactions.
Lu P, Wang YL, Linsley PS
Curr Opin Immunol. 1997
PubMed ID: 9492990
-
Cultured human decidual stromal cells express B7-1 (CD80) and B7-2 (CD86) and stimulate allogeneic T cells.
Olivares EG, Montes MJ, Oliver C, Galindo JA, Ruiz C
Biol Reprod. 1997
PubMed ID: 9282998
-
Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2.
Weiskirchen R, Erdel M, Utermann G, Bister K
Genomics. 1997
PubMed ID: 9286703
-
The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3.
Reeves RH, Patch D, Sharpe AH, Borriello F, Freeman GJ, Edelhoff S, Disteche C
Mamm Genome. 1997
PubMed ID: 9250865
-
High-resolution recombinational map of mouse chromosome 16.
Reeves RH, Rue EE, Citron MP, Cabin DE
Genomics. 1997
PubMed ID: 9244437
-
Transfection of the gene for B7-1 but not B7-2 can induce immunity to murine malignant mesothelioma.
Leong CC, Marley JV, Loh S, Milech N, Robinson BW, Garlepp MJ
Int J Cancer. 1997
PubMed ID: 9139887
-
B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation.
Borriello F, Sethna MP, Boyd SD, Schweitzer AN, Tivol EA, Jacoby D, Strom TB, Simpson EM, Freeman GJ, Sharpe AH
Immunity. 1997
PubMed ID: 9075931
-
Lck regulates Vav activation of members of the Rho family of GTPases.
Han J, Das B, Wei W, Van Aelst L, Mosteller RD, Khosravi-Far R, Westwick JK, Der CJ, Broek D
Mol Cell Biol. 1997
PubMed ID: 9032261
-
Isolation and promoter mapping of the gene encoding murine co-stimulatory factor B7-1.
Zhang H, Haasch D, Idler KB, Okasinski GF
Gene. 1996
PubMed ID: 8996079
-
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection.
Hancock WW, Sayegh MH, Zheng XG, Peach R, Linsley PS, Turka LA
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8943044
-
Subepithelial B cells in the human palatine tonsil. II. Functional characterization.
Dono M, Zupo S, Augliera A, Burgio VL, Massara R, Melagrana A, Costa M, Grossi CE, Chiorazzi N, Ferrarini M
Eur J Immunol. 1996
PubMed ID: 8814244
-
Interleukin-1 but not tumour necrosis factor alpha synergistically upregulates the granulocyte-macrophage colony-stimulating factor-induced B7-1 expression of murine Langerhans cells.
Furue M, Chang CH, Tamaki K
Br J Dermatol. 1996
PubMed ID: 8881659
-
The role of the B7-1a molecule, an alternatively spliced form of murine B7-1 (CD80), on T cell activation.
Inobe M, Aoki N, Linsley PS, Ledbetter JA, Abe R, Murakami M, Uede T
J Immunol. 1996
PubMed ID: 8752905
-
Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function.
Kariv I, Truneh A, Sweet RW
J Immunol. 1996
PubMed ID: 8683128
-
Expression and function of B7-1 and B7-2 in hapten-induced contact sensitivity.
Reiser H, Schneeberger EE
Eur J Immunol. 1996
PubMed ID: 8625983
-
Interferon-gamma and interleukin-10 inhibit antigen presentation by Langerhans cells for T helper type 1 cells by suppressing their CD80 (B7-1) expression.
Ozawa H, Aiba S, Nakagawa, Tagami H
Eur J Immunol. 1996
PubMed ID: 8605933
-
Cloning and partial characterization of the mouse B7-1 promoter.
Antonia SJ, Finley C, Muñoz-Antonia T
Immunogenetics. 1996
PubMed ID: 8575824
-
Glycosylphosphatidylinositol-modified murine B7-1 and B7-2 retain costimulator function.
Brunschwig EB, Levine E, Trefzer U, Tykocinski ML
J Immunol. 1995
PubMed ID: 7499830
-
Differential requirements of CD45 for lymphocyte development and function.
Kong YY, Kishihara K, Sumichika H, Nakamura T, Kaneko M, Nomoto K
Eur J Immunol. 1995
PubMed ID: 8566034
-
The cysteine-rich protein family of highly related LIM domain proteins.
Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC
J Biol Chem. 1995
PubMed ID: 7499425
-
Ligation of either CD2 or CD28 rescues CD4+ T cells from HIV-gp120-induced apoptosis.
Tuosto L, Piazza C, Moretti S, Modesti A, Greenlaw R, Lechler R, Lombardi G, Piccolella E
Eur J Immunol. 1995
PubMed ID: 7589092
-
Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28.
Peach RJ, Bajorath J, Naemura J, Leytze G, Greene J, Aruffo A, Linsley PS
J Biol Chem. 1995
PubMed ID: 7545666
-
Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4.
Fargeas CA, Truneh A, Reddy M, Hurle M, Sweet R, Sékaly RP
J Exp Med. 1995
PubMed ID: 7544393
-
HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71).
Chirmule N, McCloskey TW, Hu R, Kalyanaraman VS, Pahwa S
J Immunol. 1995
PubMed ID: 7541827
-
Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.
Han S, Hathcock K, Zheng B, Kepler TB, Hodes R, Kelsoe G
J Immunol. 1995
PubMed ID: 7541819
-
Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro.
Gajewski TF, Renauld JC, Van Pel A, Boon T
J Immunol. 1995
PubMed ID: 7538528
-
Activation of murine T cells by bacterial superantigens requires B7-mediated costimulation.
Muraille E, De Smedt T, Thielemans K, Urbain J, Moser M, Leo O
Cell Immunol. 1995
PubMed ID: 7538050
-
Intensity of Schistosoma mansoni infection determines alterations in hepatic drug metabolism.
Naik YS, Hasler JA
J Egypt Soc Parasitol. 1995
PubMed ID: 7602158
-
Cloning the rat homolog of the CD28/CTLA-4-ligand B7-1: structural and functional analysis.
Judge TA, Liu M, Christensen PJ, Fak JJ, Turka LA
Int Immunol. 1995
PubMed ID: 7537533
-
B7-1 expression of Langerhans cells is up-regulated by proinflammatory cytokines, and is down-regulated by interferon-gamma or by interleukin-10.
Chang CH, Furue M, Tamaki K
Eur J Immunol. 1995
PubMed ID: 7533084
-
Cloning and sequencing of the rabbit gene encoding T-cell costimulatory molecules.
Isono T, Seto A
Immunogenetics. 1995
PubMed ID: 7642234
-
Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation.
Prabhu Das MR, Zamvil SS, Borriello F, Weiner HL, Sharpe AH, Kuchroo VK
Eur J Immunol. 1995
PubMed ID: 7531145
-
CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.
Lanier LL, O'Fallon S, Somoza C, Phillips JH, Linsley PS, Okumura K, Ito D, Azuma M
J Immunol. 1995
PubMed ID: 7527824
-
Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1.
Peach RJ, Bajorath J, Brady W, Leytze G, Greene J, Naemura J, Linsley PS
J Exp Med. 1994
PubMed ID: 7964482
-
Regulation of T helper cell responses in experimental murine schistosomiasis by IL-10. Effect on expression of B7 and B7-2 costimulatory molecules by macrophages.
Flores Villanueva PO, Reiser H, Stadecker MJ
J Immunol. 1994
PubMed ID: 7525726
-
Characterization of the murine B7-1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location of chromosome 16, band B5.
Borriello F, Freeman GJ, Edelhoff S, Disteche CM, Nadler LM, Sharpe AH
J Immunol. 1994
PubMed ID: 7525722
-
Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.
Lenschow DJ, Sperling AI, Cooke MP, Freeman G, Rhee L, Decker DC, Gray G, Nadler LM, Goodnow CC, Bluestone JA
J Immunol. 1994
PubMed ID: 7519638
-
Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.
Hathcock KS, Laszlo G, Pucillo C, Linsley P, Hodes RJ
J Exp Med. 1994
PubMed ID: 7519245
-
The B7 and CD28 receptor families.
June CH, Bluestone JA, Nadler LM, Thompson CB
Immunol Today. 1994
PubMed ID: 7522010
-
IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2.
Stack RM, Lenschow DJ, Gray GS, Bluestone JA, Fitch FW
J Immunol. 1994
PubMed ID: 7515912
-
In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice.
Blazar BR, Taylor PA, Linsley PS, Vallera DA
Blood. 1994
PubMed ID: 7515723
-
Nef protein of HIV-1 has B-cell stimulatory activity.
Chirmule N, Oyaizu N, Saxinger C, Pahwa S
AIDS. 1994
PubMed ID: 8086129
-
Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.
Larsen CP, Ritchie SC, Hendrix R, Linsley PS, Hathcock KS, Hodes RJ, Lowry RP, Pearson TC
J Immunol. 1994
PubMed ID: 7514631
-
Identification of an alternatively spliced form of the murine homologue of B7.
Inobe M, Linsley PS, Ledbetter JA, Nagai Y, Tamakoshi M, Uede T
Biochem Biophys Res Commun. 1994
PubMed ID: 7513163
-
The costimulatory molecule B7 is expressed in the medullary region of the murine thymus.
Reiser H, Schneeberger EE
Immunology. 1994
PubMed ID: 7518793
-
Expression and functional analysis of murine B7 delineated by a novel monoclonal antibody.
Powers GD, Faherty DA, Connaughton SE, Biondi DA, Godfrey DI, Gault A, Chen CY, Nabavi N
Cell Immunol. 1994
PubMed ID: 7509723
-
Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.
Freeman GJ, Borriello F, Hodes RJ, Reiser H, Gribben JG, Ng JW, Kim J, Goldberg JM, Hathcock K, Laszlo G
J Exp Med. 1993
PubMed ID: 7504059
-
Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice.
Freeman GJ, Borriello F, Hodes RJ, Reiser H, Hathcock KS, Laszlo G, McKnight AJ, Kim J, Du L, Lombard DB
Science. 1993
PubMed ID: 7694362
-
Suppression in transformed avian fibroblasts of a gene (crp) encoding a cysteine-rich protein containing LIM domains.
Weiskirchen R, Bister K
Oncogene. 1993
PubMed ID: 8361751
-
Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1.
Lane P, Gerhard W, Hubele S, Lanzavecchia A, McConnell F
Immunology. 1993
PubMed ID: 8244464
-
Genomic organization of the mouse B-lymphocyte activation antigen B7.
Selvakumar A, White PC, Dupont B
Immunogenetics. 1993
PubMed ID: 7686531
-
Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells.
Morse HC
J Immunol. 1992
PubMed ID: 1431091
-
Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen.
Liu Y, Jones B, Brady W, Janeway CA, Linsley PS, Linley PS
Eur J Immunol. 1992
PubMed ID: 1385153
-
Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.
Larsen CP, Ritchie SC, Pearson TC, Linsley PS, Lowry RP
J Exp Med. 1992
PubMed ID: 1328465
-
Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells.
Razi-Wolf Z, Freeman GJ, Galvin F, Benacerraf B, Nadler L, Reiser H
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1373896
-
The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21.
Freeman GJ, Disteche CM, Gribben JG, Adler DA, Freedman AS, Dougery J, Nadler LM
Blood. 1992
PubMed ID: 1370389
-
Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7.
Selvakumar A, Mohanraj BK, Eddy RL, Shows TB, White PC, Dupont B
Immunogenetics. 1992
PubMed ID: 1377173
-
Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.
Freeman GJ, Gray GS, Gimmi CD, Lombard DB, Zhou LJ, White M, Fingeroth JD, Gribben JG, Nadler LM
J Exp Med. 1991
PubMed ID: 1714935
-
The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells.
Koulova L, Clark EA, Shu G, Dupont B
J Exp Med. 1991
PubMed ID: 1847724
-
Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.
Linsley PS, Brady W, Grosmaire L, Aruffo A, Damle NK, Ledbetter JA
J Exp Med. 1991
PubMed ID: 1847722
-
Identification and gene cloning of a new phosphatidylinositol-linked antigen expressed on mature lymphocytes. Down-regulation by lymphocyte activation.
Kubota H, Okazaki H, Onuma M, Kano S, Hattori M, Minato N
J Immunol. 1990
PubMed ID: 2147207
-
T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.
Linsley PS, Clark EA, Ledbetter JA
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2164219
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B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells.
Freeman GJ, Freedman AS, Segil JM, Lee G, Whitman JF, Nadler LM
J Immunol. 1989
PubMed ID: 2794510
Model Organism Phenotype Links
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