Home CD28
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(Human) GRCh37 - chr2:204571198..204603636 (32.44 kb) View in Genome Browser
(Mouse) NCBIM37 - chr1:60773644..60830203 (56.56 kb) View in Genome Browser
(Rat) RGSC3.4 - chr9:59342273..59367743 (25.47 kb) View in Genome Browser
HaemAtlas Expression Table for CD28:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for CD28:The CD28 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| CD28 | LRRC23 | HPRD, BioGRID | empirical | 7523532 1313075 1847722 |
| CD28 | DUSP14 | HPRD, BioGRID | empirical | 11123293 |
| CD28 | AP2M1 | Reactome | predicted | 11285224 |
| CD28 | GRB2 | HPRD, BioGRID | empirical | 8576157 7737275 9694876 |
| CD28 | IL12A | HPRD | empirical | 7516408 |
| CD28 | ITK | HPRD | empirical | 10586033 8992971 15144186 |
| CD28 | LCK | HPRD | empirical | 10430626 |
| CD28 | NSF | HPRD | empirical | 11680900 |
| CD28 | PIK3CG | HPRD | empirical | 9915850 |
| CD28 | PIK3R1 | HPRD, BioGRID | empirical | 8621607 7737275 |
| CD28 | PIK3R2 | HPRD | empirical | 7509360 8080844 |
| CD28 | PLCG1 | HPRD | empirical | 8386518 |
| CD28 | PTPRC | HPRD | empirical | 1355979 |
| CD28 | CD247 | HPRD | empirical | 8760790 |
| CD28 | CD4 | HPRD | empirical | 7539755 |
| CD28 | GRAP2 | HPRD, BioGRID | empirical | 10820259 |
| CD28 | CD80 | HPRD, IntAct, BioGRID | empirical | 7545666 21982860 |
| CD28 | CD86 | HPRD | empirical | 11021528 7513726 |
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Type 1 Diabetes Publications: 23
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Targeting of a T cell agonist peptide to lysosomes by DNA vaccination induces tolerance in the nonobese diabetic mouse.
Rivas EI, Driver JP, Garabatos N, Presa M, Mora C, Rodriguez F, Serreze DV, Stratmann T
J Immunol. 2011
PubMed ID: 21346228
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Polymorphisms in the CD28/CTLA4/ICOS genes: role in malignant melanoma susceptibility and prognosis?
Bouwhuis MG, Gast A, Figl A, Eggermont AM, Hemminki K, Schadendorf D, Kumar R
Cancer Immunol Immunother. 2009
PubMed ID: 19672595
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Spontaneous Development of a Pancreatic Exocrine Disease in CD28-Deficient NOD Mice.
Meagher C, Tang Q, Fife BT, Bour-Jordan H, Wu J, Pardoux C, Bi M, Melli K, Bluestone JA
J Immunol. 2008
PubMed ID: 18523243
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CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity.
Calzascia T, Pellegrini M, Lin A, Garza KM, Elford AR, Shahinian A, Ohashi PS, Mak TW
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18287017
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Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse.
Bour-Jordan H, Salomon BL, Thompson HL, Santos R, Abbas AK, Bluestone JA
J Immunol. 2007
PubMed ID: 17617592
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Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.
Bour-Jordan H, Salomon BL, Thompson HL, Szot GL, Bernhard MR, Bluestone JA
J Clin Invest. 2004
PubMed ID: 15467837
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Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.
Wicker LS, Chamberlain G, Hunter K, Rainbow D, Howlett S, Tiffen P, Clark J, Gonzalez-Munoz A, Cumiskey AM, Rosa RL, Howson JM, Smink LJ, Kingsnorth A, Lyons PA, Gregory S, Rogers J, Todd JA, Peterson LB
J Immunol. 2004
PubMed ID: 15210771
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[Surface expression of costimulatory molecules CD28/CTLA-4 on peripheral blood T lymphocytes in the course of type 1 diabetes mellitus in children and adolescents]
Pawłowski P, Urban M, Stasiak-Barmuta A
Endokrynol Diabetol Chor Przemiany Materii Wieku R. 2004
PubMed ID: 15504310
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Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo.
Millar DG, Garza KM, Odermatt B, Elford AR, Ono N, Li Z, Ohashi PS
Nat Med. 2003
PubMed ID: 14625545
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Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanisms.
Demirci G, Strom TB, Li XC
J Immunol. 2003
PubMed ID: 14500690
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TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.
Belghith M, Bluestone JA, Barriot S, Mégret J, Bach JF, Chatenoud L
Nat Med. 2003
PubMed ID: 12937416
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Role of the B7-CD28/CTLA-4 pathway in autoimmune disease.
Chang TT, Kuchroo VK, Sharpe AH
Curr Dir Autoimmun. 2002
PubMed ID: 11826754
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Further mapping of the Idd5.1 locus for autoimmune diabetes in NOD mice.
Lamhamedi-Cherradi SE, Boulard O, Gonzalez C, Kassis N, Damotte D, Eloy L, Fluteau G, Lévi-Strauss M, Garchon HJ
Diabetes. 2001
PubMed ID: 11723074
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Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with type 1 diabetes in the Japanese population.
Ihara K, Ahmed S, Nakao F, Kinukawa N, Kuromaru R, Matsuura N, Iwata I, Nagafuchi S, Kohno H, Miyako K, Hara T
Immunogenetics. 2001
PubMed ID: 11685455
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CTLA-4-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice.
Bergman ML, Cilio CM, Penha-Gonçalves C, Lamhamedi-Cherradi SE, Löfgren A, Colucci F, Lejon K, Garchon HJ, Holmberg D
J Autoimmun. 2001
PubMed ID: 11247636
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Low dose streptozotocin-induced diabetes in rat insulin promoter-mCD80-transgenic mice is T cell autoantigen-specific and CD28 dependent.
Pechhold K, Patterson NB, Blum C, Fleischacker CL, Boehm BO, Harlan DM
J Immunol. 2001
PubMed ID: 11160314
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NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.
Hill NJ, Lyons PA, Armitage N, Todd JA, Wicker LS, Peterson LB
Diabetes. 2000
PubMed ID: 11016460
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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA
Immunity. 2000
PubMed ID: 10795741
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Low CD86 expression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-4 up-regulation.
Dahlén E, Hedlund G, Dawe K
J Immunol. 2000
PubMed ID: 10679081
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A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade.
Girvin AM, Dal Canto MC, Rhee L, Salomon B, Sharpe A, Bluestone JA, Miller SD
J Immunol. 2000
PubMed ID: 10605004
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Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism.
Arreaza GA, Cameron MJ, Jaramillo A, Gill BM, Hardy D, Laupland KB, Rapoport MJ, Zucker P, Chakrabarti S, Chensue SW, Qin HY, Singh B, Delovitch TL
J Clin Invest. 1997
PubMed ID: 9410902
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CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes.
Lenschow DJ, Herold KC, Rhee L, Patel B, Koons A, Qin HY, Fuchs E, Singh B, Thompson CB, Bluestone JA
Immunity. 1996
PubMed ID: 8808683
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Genetics of a multifactorial disease: autoimmune type 1 diabetes mellitus.
Cornall RJ
Clin Sci (Lond). 1993
PubMed ID: 8384947
Publications: 620
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Cutting edge: A role for inside-out signaling in TCR regulation of CD28 ligand binding.
Sanchez-Lockhart M, Kim M, Miller J
J Immunol. 2011
PubMed ID: 22068237
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T cell-signaling network analysis reveals distinct differences between CD28 and CD2 costimulation responses in various subsets and in the MAPK pathway between resting and activated regulatory T cells.
Kalland ME, Oberprieler NG, Vang T, Taskén K, Torgersen KM
J Immunol. 2011
PubMed ID: 22013130
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Blockade of Notch ligand δ1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation.
Riella LV, Ueno T, Batal I, De Serres SA, Bassil R, Elyaman W, Yagita H, Medina-Pestana JO, Chandraker A, Najafian N
J Immunol. 2011
PubMed ID: 21949024
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CTLA-4, CD28, and ICOS gene polymorphism associations with non-small-cell lung cancer.
Karabon L, Pawlak E, Tomkiewicz A, Jedynak A, Passowicz-Muszynska E, Zajda K, Jonkisz A, Jankowska R, Krzakowski M, Frydecka I
Hum Immunol. 2011
PubMed ID: 21669243
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CpG and non-CpG oligodeoxynucleotides directly costimulate mouse and human CD4+ T cells through a TLR9- and MyD88-independent mechanism.
Landrigan A, Wong MT, Utz PJ
J Immunol. 2011
PubMed ID: 21844387
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Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock.
Arad G, Levy R, Nasie I, Hillman D, Rotfogel Z, Barash U, Supper E, Shpilka T, Minis A, Kaempfer R
PLoS Biol. 2011
PubMed ID: 21931534
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CD28 expressed on malignant plasma cells induces a prosurvival and immunosuppressive microenvironment.
Nair JR, Carlson LM, Koorella C, Rozanski CH, Byrne GE, Bergsagel PL, Shaughnessy JP, Boise LH, Chanan-Khan A, Lee KP
J Immunol. 2011
PubMed ID: 21715687
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Sustained antibody responses depend on CD28 function in bone marrow-resident plasma cells.
Rozanski CH, Arens R, Carlson LM, Nair J, Boise LH, Chanan-Khan AA, Schoenberger SP, Lee KP
J Exp Med. 2011
PubMed ID: 21690252
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Roles of CD28, CTLA4, and inducible costimulator in acute graft-versus-host disease in mice.
Li J, Semple K, Suh WK, Liu C, Chen F, Blazar BR, Yu XZ
Biol Blood Marrow Transplant. 2011
PubMed ID: 21447398
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CD4+CD28 null T lymphocytes are expanded in young women with polycystic ovary syndrome.
Niccoli G, Apa R, Lanzone A, Liuzzo G, Spaziani C, Sagnella F, Cosentino N, Moro F, Martinez D, Morciano A, Bacà M, Pazzano V, Gangale MF, Tropea A, Crea F
Fertil Steril. 2011
PubMed ID: 21324454
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T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse.
Moran AE, Holzapfel KL, Xing Y, Cunningham NR, Maltzman JS, Punt J, Hogquist KA
J Exp Med. 2011
PubMed ID: 21606508
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B7-h2 is a costimulatory ligand for CD28 in human.
Yao S, Zhu Y, Zhu G, Augustine M, Zheng L, Goode DJ, Broadwater M, Ruff W, Flies S, Xu H, Flies D, Luo L, Wang S, Chen L
Immunity. 2011
PubMed ID: 21530327
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CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients.
Savoldo B, Ramos CA, Liu E, Mims MP, Keating MJ, Carrum G, Kamble RT, Bollard CM, Gee AP, Mei Z, Liu H, Grilley B, Rooney CM, Heslop HE, Brenner MK, Dotti G
J Clin Invest. 2011
PubMed ID: 21540550
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Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference.
Sang W, Zhou C, Cheng N, Li Z, Zeng L, Xu K
Immunol Lett. 2011
PubMed ID: 21277900
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A novel association between filamin A and NF-κB inducing kinase couples CD28 to inhibitor of NF-κB kinase α and NF-κB activation.
Muscolini M, Sajeva A, Caristi S, Tuosto L
Immunol Lett. 2011
PubMed ID: 21277899
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Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo.
Dolfi DV, Duttagupta PA, Boesteanu AC, Mueller YM, Oliai CH, Borowski AB, Katsikis PD
J Immunol. 2011
PubMed ID: 21389258
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Association of CTLA4, CD28 and ICOS gene polymorphisms with clinicopathologic characteristics of childhood IgA nephropathy in Korean population.
Kim HJ, Chung JH, Kang S, Kim SK, Cho BS, Kim SD, Hahn WH
J Genet. 2011
PubMed ID: 21677403
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Differential B7-CD28 costimulatory requirements for stable and inflationary mouse cytomegalovirus-specific memory CD8 T cell populations.
Arens R, Loewendorf A, Redeker A, Sierro S, Boon L, Klenerman P, Benedict CA, Schoenberger SP
J Immunol. 2011
PubMed ID: 21357256
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NF-κB family of transcription factors: biochemical players of CD28 co-stimulation.
Tuosto L
Immunol Lett. 2011
PubMed ID: 20863851
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Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling.
Semple K, Nguyen A, Yu Y, Wang H, Anasetti C, Yu XZ
Blood. 2011
PubMed ID: 21245484
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CD28 expression by peripheral blood lymphocytes as a potential predictor of the development of de novo malignancies in long-term survivors after liver transplantation.
Boleslawski E, Othman SB, Aoudjehane L, Chouzenoux S, Scatton O, Soubrane O, Calmus Y, Delhem N, Conti F
Liver Transpl. 2011
PubMed ID: 21384512
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Immunoregulatory gene polymorphisms in women with preeclampsia.
Pendeloski KP, Sass N, Torloni MR, Mattar R, Moron AF, Franchim CS, Daher S
Hypertens Res. 2011
PubMed ID: 21160481
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Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1).
Vaeth M, Gogishvili T, Bopp T, Klein M, Berberich-Siebelt F, Gattenloehner S, Avots A, Sparwasser T, Grebe N, Schmitt E, Hünig T, Serfling E, Bodor J
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21262800
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CD28 costimulation regulates FOXP3 in a RelA/NF-κB-dependent mechanism.
Soligo M, Camperio C, Caristi S, Scottà C, Del Porto P, Costanzo A, Mantel PY, Schmidt-Weber CB, Piccolella E
Eur J Immunol. 2011
PubMed ID: 21268019
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The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice.
Salek-Ardakani S, Flynn R, Arens R, Yagita H, Smith GL, Borst J, Schoenberger SP, Croft M
J Clin Invest. 2011
PubMed ID: 21183789
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Loss of surface antigens is a conserved feature of apoptotic lymphocytes from several mammalian species.
Diaz D, Chara L, Chevarria J, Ubeda M, Muñoz L, Barcenilla H, Sánchez MA, Moreno Z, Monserrat J, Albillos A, Prieto A, Alvarez-Mon M
Cell Immunol. 2011
PubMed ID: 21745657
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Association of CD28 IVS3 +17T/C polymorphism with soluble CD28 in rheumatoid arthritis.
Ledezma-Lozano IY, Padilla-Martínez JJ, Leyva-Torres SD, Parra-Rojas I, Ramírez-Dueñas MG, Pereira-Suárez AL, Rangel-Villalobos H, Ruiz-Quezada SL, Sánchez-Hernández PE, Muñoz-Valle JF
Dis Markers. 2011
PubMed ID: 21508506
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A superagonistic monoclonal antibody for CD28 ameliorates crescentic glomerulonephritis in wistar-kyoto rats.
Takabatake Y, Li XK, Mizui M, Miyasato K, Matsui I, Kawada N, Imai E, Hünig T, Takahara S, Wada T, Furuichi K, Rakugi H, Isaka Y
Mol Med. 2011
PubMed ID: 21487638
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Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4.
Botturi K, Lacoeuille Y, Cavaillès A, Vervloet D, Magnan A
Respir Res. 2011
PubMed ID: 21356099
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Differential requirements for CD80/86-CD28 costimulation in primary and memory CD4 T cell responses to vaccinia virus.
Fuse S, Tsai CY, Rommereim LM, Zhang W, Usherwood EJ
Cell Immunol. 2011
PubMed ID: 21040905
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TIM-3: a novel regulatory molecule of alloimmune activation.
Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N
J Immunol. 2010
PubMed ID: 20956339
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Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
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CD28 exerts protective and detrimental effects in a pulmonary model of paracoccidioidomycosis.
Felonato M, Pina A, Bernardino S, Loures FV, de Araujo EF, Calich VL
Infect Immun. 2010
PubMed ID: 20713624
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Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans.
Hughes LB, Reynolds RJ, Brown EE, Kelley JM, Thomson B, Conn DL, Jonas BL, Westfall AO, Padilla MA, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Plenge RM, Bridges SL
Arthritis Rheum. 2010
PubMed ID: 20973039
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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL. Immunity. 1995. 3: 87-98.
Boise LH, Minn AJ, Noel PJ, June CH, Accavitti MA, Lindsten T, Thompson CB
J Immunol. 2010
PubMed ID: 20858890
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Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation.
Yokosuka T, Kobayashi W, Takamatsu M, Sakata-Sogawa K, Zeng H, Hashimoto-Tane A, Yagita H, Tokunaga M, Saito T
Immunity. 2010
PubMed ID: 20870175
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Association of CD28 gene polymorphism with cervical cancer risk in a Chinese population.
Chen X, Li H, Qiao Y, Yu D, Guo H, Tan W, Lin D
Int J Immunogenet. 2010
PubMed ID: 20846283
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Association between HLA-DRB1, HLA-DRQB1 alleles, and CD4(+)CD28 (null) T cells in a Chinese population with coronary heart disease.
Sun W, Cui Y, Zhen L, Huang L
Mol Biol Rep. 2010
PubMed ID: 20842443
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In vitro propagation and dynamics of T cells from skin biopsies by methods using interleukins-2 and -4 or anti-CD3/CD28 antibody-coated microbeads.
Hashizume H, Hansen A, Poulsen LK, Thomsen AR, Takigawa M, Thestrup-Pedersen K
Acta Derm Venereol. 2010
PubMed ID: 20814620
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Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.
Chang JS, Wiemels JL, Chokkalingam AP, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Green J, May SL, Kiley VA, Wiencke JK, Buffler PA
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20716621
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Peripheral blood gene expression of B7 and CD28 family members associated with tumor progression and microscopic lymphovascular invasion in colon cancer patients.
Lee H, Kim JH, Yang SY, Kong J, Oh M, Jeong DH, Chung JI, Bae KB, Shin JY, Hong KH, Choi I
J Cancer Res Clin Oncol. 2010
PubMed ID: 20140740
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CD 28 gene polymorphism and plasma concentration of soluble CD 28 in Iranian patients with visceral leishmaniasis.
Hashemi SH, Hajilooi M, Fallah M, Naghili B
Trop Biomed. 2010
PubMed ID: 20962715
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Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.
Ying H, Yang L, Qiao G, Li Z, Zhang L, Yin F, Xie D, Zhang J
J Immunol. 2010
PubMed ID: 20601598
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The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus.
Grujic M, Bartholdy C, Remy M, Pinschewer DD, Christensen JP, Thomsen AR
J Immunol. 2010
PubMed ID: 20601595
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Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
Lee KM, Baris D, Zhang Y, Hosgood HD, Menashe I, Yeager M, Zahm SH, Wang SS, Purdue MP, Chanock S, Zheng T, Rothman N, Lan Q
Am J Hematol. 2010
PubMed ID: 20568250
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Genetic polymorphisms of the T-cell coreceptors CD28 and CTLA-4 in Afro- and Euro-Brazilians.
Pincerati MR, Dalla-Costa R, Pavoni DP, Petzl-Erler ML
Int J Immunogenet. 2010
PubMed ID: 20477885
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Polymorphisms in the 2q33 and 3q21 chromosome regions including T-cell coreceptor and ligand genes may influence susceptibility to pemphigus foliaceus.
Dalla-Costa R, Pincerati MR, Beltrame MH, Malheiros D, Petzl-Erler ML
Hum Immunol. 2010
PubMed ID: 20433886
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A role for dendritic cells in bleomycin-induced pulmonary fibrosis in mice?
Bantsimba-Malanda C, Marchal-Sommé J, Goven D, Freynet O, Michel L, Crestani B, Soler P
Am J Respir Crit Care Med. 2010
PubMed ID: 20395561
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The influence of CTLA-4 gene polymorphism on long-term kidney allograft function in Caucasian recipients.
Kusztal M, Kościelska-Kasprzak K, Drulis-Fajdasz D, Magott-Procelewska M, Patrzałek D, Janczak D, Chudoba P, Klinger M
Transpl Immunol. 2010
PubMed ID: 20470888
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Association of T-cell regulatory gene polymorphisms with oral squamous cell carcinoma.
Kämmerer PW, Toyoshima T, Schöder F, Kämmerer P, Kuhr K, Brieger J, Al-Nawas B
Oral Oncol. 2010
PubMed ID: 20435510
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Combinatorial signals from CD28 differentially regulate human immunodeficiency virus transcription in T cells.
Natarajan M, August A, Henderson AJ
J Biol Chem. 2010
PubMed ID: 20368329
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Investigation of CTLA-4 and CD28 gene polymorphisms in patients with diabetes mellitus type 2 using PCR-RFLP in a Turkish population.
Uzer E, Dilmec F, Akkafa F, Boduroglu O, van Kuilenburg AB
West Indian Med J. 2010
PubMed ID: 21291098
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Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R
Pediatr Pulmonol. 2010
PubMed ID: 20503287
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CD28 facilitates the generation of Foxp3(-) cytokine responsive regulatory T cell precursors.
Lio CW, Dodson LF, Deppong CM, Hsieh CS, Green JM
J Immunol. 2010
PubMed ID: 20421644
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Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development.
Ouyang W, Beckett O, Ma Q, Li MO
Immunity. 2010
PubMed ID: 20471291
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Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation.
Kleinschnitz C, Schwab N, Kraft P, Hagedorn I, Dreykluft A, Schwarz T, Austinat M, Nieswandt B, Wiendl H, Stoll G
Blood. 2010
PubMed ID: 20215643
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Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL, Thio CL
J Infect Dis. 2010
PubMed ID: 20331378
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T-cell activation profiles in different granulomatous interstitial lung diseases--a role for CD8+CD28(null) cells?
Heron M, Claessen AM, Grutters JC, van den Bosch JM
Clin Exp Immunol. 2010
PubMed ID: 20030671
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Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development.
Vang KB, Yang J, Pagán AJ, Li LX, Wang J, Green JM, Beg AA, Farrar MA
J Immunol. 2010
PubMed ID: 20228198
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New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
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Multiple common variants for celiac disease influencing immune gene expression.
Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Adány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek WH, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA
Nat Genet. 2010
PubMed ID: 20190752
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Association of the CD28/CTLA4/ICOS polymorphisms with susceptibility to rheumatoid arthritis.
Kim YO, Kim HJ, Kim SK, Chung JH, Hong SJ
Clin Chem Lab Med. 2010
PubMed ID: 20113255
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Reduced T cell expansion by a superantigen as a result of impaired B cell development in mice deficient for the p85alpha regulatory subunit of PI3K.
Arimura Y, Ezaki T, Koyanagi M, Uchiyama T, Koyasu S, Yagi J
J Leukoc Biol. 2010
PubMed ID: 20007249
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Interaction of immunological genes on chromosome 2q33 and IFNG in susceptibility to cervical cancer.
Ivansson EL, Juko-Pecirep I, Gyllensten UB
Gynecol Oncol. 2010
PubMed ID: 19959217
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T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis.
Cho JH, Kim HO, Surh CD, Sprent J
Immunity. 2010
PubMed ID: 20137986
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Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation.
Bhatia S, Sun K, Almo SC, Nathenson SG, Hodes RJ
J Immunol. 2010
PubMed ID: 20065109
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Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation.
Poirier N, Azimzadeh AM, Zhang T, Dilek N, Mary C, Nguyen B, Tillou X, Wu G, Reneaudin K, Hervouet J, Martinet B, Coulon F, Allain-Launay E, Karam G, Soulillou JP, Pierson RN, Blancho G, Vanhove B
Sci Transl Med. 2010
PubMed ID: 20371478
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Defective T-cell receptor-induced apoptosis of T cells and rejection of transplanted immunogenic tumors in p53(-/-) mice.
Singh N, Huang L, Qin H
Eur J Immunol. 2010
PubMed ID: 19950180
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Influence of CTLA-4/CD28/ICOS gene polymorphisms on the susceptibility to cervical squamous cell carcinoma and stage of differentiation in the Polish population.
Pawlak E, Karabon L, Wlodarska-Polinska I, Jedynak A, Jonkisz A, Tomkiewicz A, Kornafel J, Stepien M, Ignatowicz A, Lebioda A, Dobosz T, Frydecka I
Hum Immunol. 2010
PubMed ID: 19913589
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Altered CD28 and CD95 mRNA expression in peripheral blood mononuclear cells from elderly patients with primary non-small cell lung cancer.
Wang L, Pan XD, Xie Y, Zhang GB, Jiang M, Zheng L, Wang JH, Shi JF, Zhang XG
Chin Med J (Engl). 2010
PubMed ID: 20137575
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CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses.
Obar JJ, Molloy MJ, Jellison ER, Stoklasek TA, Zhang W, Usherwood EJ, Lefrançois L
Proc Natl Acad Sci U S A. 2010
PubMed ID: 19966302
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Functional dichotomy between NKG2D and CD28-mediated co-stimulation in human CD8+ T cells.
Rajasekaran K, Xiong V, Fong L, Gorski J, Malarkannan S
PLoS One. 2010
PubMed ID: 20844584
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CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosis.
Gilani SR, Vuga LJ, Lindell KO, Gibson KF, Xue J, Kaminski N, Valentine VG, Lindsay EK, George MP, Steele C, Duncan SR
PLoS One. 2010
PubMed ID: 20126467
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CD4(+)CD25(+) regulatory T cells resist a novel form of CD28- and Fas-dependent p53-induced T cell apoptosis.
Singh N, Yamamoto M, Takami M, Seki Y, Takezaki M, Mellor AL, Iwashima M
J Immunol. 2010
PubMed ID: 19949106
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Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW, Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P, YEAR Consortium, Altshuler D, Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA, Worthington J, Klareskog L, Gregersen PK, Daly MJ, Plenge RM
Nat Genet. 2009
PubMed ID: 19898481
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Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q
Occup Environ Med. 2009
PubMed ID: 19773279
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Superagonistic CD28 stimulation of allogeneic T cells protects from acute graft-versus-host disease.
Beyersdorf N, Ding X, Hünig T, Kerkau T
Blood. 2009
PubMed ID: 19721011
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Association and interaction analyses of eight genes under asthma linkage peaks.
Ferreira MA, Zhao ZZ, Thomsen SF, James M, Evans DM, Postmus PE, Kyvik KO, Backer V, Boomsma DI, Martin NG, Montgomery GW, Duffy DL
Allergy. 2009
PubMed ID: 19824886
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Simvastatin does not prevent acute cardiac allograft rejection in CD28-deficient mice.
Schramm R, Schmits R, Schäfers HJ, Menger MD
Inflamm Res. 2009
PubMed ID: 19418202
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Regulatory T cells modulate postischemic neovascularization.
Zouggari Y, Ait-Oufella H, Waeckel L, Vilar J, Loinard C, Cochain C, Récalde A, Duriez M, Levy BI, Lutgens E, Lutgens E, Mallat Z, Silvestre JS
Circulation. 2009
PubMed ID: 19770391
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Genetic polymorphisms of immunoregulatory proteins in acute renal allograft rejection.
Krichen H, Sfar I, Jendoubi-Ayed S, Makhlouf M, Ben Rhomdhane T, Bardi R, Aouadi H, Ben Abdallah T, Ayed K, Gorgi Y
Transplant Proc. 2009
PubMed ID: 19857736
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T cell infiltrates in the muscles of patients with dermatomyositis and polymyositis are dominated by CD28null T cells.
Fasth AE, Dastmalchi M, Rahbar A, Salomonsson S, Pandya JM, Lindroos E, Nennesmo I, Malmberg KJ, Söderberg-Nauclér C, Trollmo C, Lundberg IE, Malmström V
J Immunol. 2009
PubMed ID: 19752224
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Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions.
Kim SH, Lee JE, Kim SH, Jee YK, Kim YK, Park HS, Min KU, Park HW, The Adverse Drug Reaction Research Group in Korea
Clin Exp Allergy. 2009
PubMed ID: 19735272
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Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.
Mingueneau M, Roncagalli R, Grégoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B
Immunity. 2009
PubMed ID: 19682930
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Common genetic variants in candidate genes and risk of familial lymphoid malignancies.
Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR
Br J Haematol. 2009
PubMed ID: 19573080
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TGF-beta promotes Th17 cell development through inhibition of SOCS3.
Qin H, Wang L, Feng T, Elson CO, Niyongere SA, Lee SJ, Reynolds SL, Weaver CT, Roarty K, Serra R, Benveniste EN, Cong Y
J Immunol. 2009
PubMed ID: 19535626
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Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulation.
Dodson LF, Boomer JS, Deppong CM, Shah DD, Sim J, Bricker TL, Russell JH, Green JM
Mol Cell Biol. 2009
PubMed ID: 19398586
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Distinct roles of CD28- and CD40 ligand-mediated costimulation in the development of protective immunity and pathology during Chlamydia muridarum urogenital infection in mice.
Chen L, Cheng W, Shivshankar P, Lei L, Zhang X, Wu Y, Yeh IT, Zhong G
Infect Immun. 2009
PubMed ID: 19398542
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Cutting edge: CD28 engagement releases antigen-activated invariant NKT cells from the inhibitory effects of PD-1.
Wang J, Cheng L, Wondimu Z, Swain M, Santamaria P, Yang Y
J Immunol. 2009
PubMed ID: 19454657
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Surface CD152 (CTLA-4) expression and signaling dictates longevity of CD28null T cells.
Hoff H, Knieke K, Cabail Z, Hirseland H, Vratsanos G, Burmester GR, Jorch G, Nadler SG, Bröker B, Hebel K, Brunner-Weinzierl MC
J Immunol. 2009
PubMed ID: 19380781
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T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue.
David R, Ma L, Ivetic A, Takesono A, Ridley AJ, Chai JG, Tybulewicz VL, Marelli-Berg FM
Blood. 2009
PubMed ID: 19060239
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CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.
Kurtz J, Raval F, Vallot C, Der J, Sykes M
Blood. 2009
PubMed ID: 19179471
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p85beta phosphoinositide 3-kinase regulates CD28 coreceptor function.
Alcázar I, Cortés I, Zaballos A, Hernandez C, Fruman DA, Barber DF, Carrera AC
Blood. 2009
PubMed ID: 19190244
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A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia.
Chen X, Bai F, Sokol L, Zhou J, Ren A, Painter JS, Liu J, Sallman DA, Chen YA, Yoder JA, Djeu JY, Loughran TP, Epling-Burnette PK, Wei S
Blood. 2009
PubMed ID: 19075187
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Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
Wollscheid B, Bausch-Fluck D, Henderson C, O'Brien R, Bibel M, Schiess R, Aebersold R, Watts JD
Nat Biotechnol. 2009
PubMed ID: 19349973
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CD28/B7-mediated co-stimulation is critical for early control of murine cytomegalovirus infection.
Cook CH, Chen L, Wen J, Zimmerman P, Zhang Y, Trgovcich J, Liu Y, Gao JX
Viral Immunol. 2009
PubMed ID: 19326996
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Modulation of T lymphocyte replicative senescence via TNF-{alpha} inhibition: role of caspase-3.
Parish ST, Wu JE, Effros RB
J Immunol. 2009
PubMed ID: 19299722
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The association of CTLA-4 and CD28 gene polymorphisms with idiopathic ischemic stroke in the paediatric population.
Wang JJ, Jiang LQ, He B, Shi KL, Li JW, Zou LP
Int J Immunogenet. 2009
PubMed ID: 19284445
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Memory T cells need CD28 costimulation to remember.
Boesteanu AC, Katsikis PD
Semin Immunol. 2009
PubMed ID: 19268606
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Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
Pediatr Infect Dis J. 2009
PubMed ID: 19258923
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Microarray analysis reveals similarity between CD8+CD28- T cells from young and elderly persons, but not of CD8+CD28+ T cells.
Lazuardi L, Herndler-Brandstetter D, Brunner S, Laschober GT, Lepperdinger G, Grubeck-Loebenstein B
Biogerontology. 2009
PubMed ID: 18751903
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Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.
Carpenito C, Milone MC, Hassan R, Simonet JC, Lakhal M, Suhoski MM, Varela-Rohena A, Haines KM, Heitjan DF, Albelda SM, Carroll RG, Riley JL, Pastan I, June CH
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19211796
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Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells.
Salek-Ardakani S, Arens R, Flynn R, Sette A, Schoenberger SP, Croft M
J Immunol. 2009
PubMed ID: 19234186
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T cell senescence and contraction of T cell repertoire diversity in patients with chronic obstructive pulmonary disease.
Lambers C, Hacker S, Posch M, Hoetzenecker K, Pollreisz A, Lichtenauer M, Klepetko W, Ankersmit HJ
Clin Exp Immunol. 2009
PubMed ID: 19220836
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Gold- and silver-induced murine autoimmunity--requirement for cytokines and CD28 in murine heavy metal-induced autoimmunity.
Havarinasab S, Pollard KM, Hultman P
Clin Exp Immunol. 2009
PubMed ID: 19077085
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Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.
Linterman MA, Rigby RJ, Wong R, Silva D, Withers D, Anderson G, Verma NK, Brink R, Hutloff A, Goodnow CC, Vinuesa CG
Immunity. 2009
PubMed ID: 19217324
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CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance.
Friedline RH, Brown DS, Nguyen H, Kornfeld H, Lee J, Zhang Y, Appleby M, Der SD, Kang J, Chambers CA
J Exp Med. 2009
PubMed ID: 19188497
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Association of genetic variation in inducible costimulator gene with outcome of kidney transplantation.
Haimila K, Turpeinen H, Alakulppi NS, Kyllönen LE, Salmela KT, Partanen J
Transplantation. 2009
PubMed ID: 19202444
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The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells.
Park SG, Schulze-Luehrman J, Hayden MS, Hashimoto N, Ogawa W, Kasuga M, Ghosh S
Nat Immunol. 2009
PubMed ID: 19122654
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Blocking effect of an immuno-suppressive agent, cynarin, on CD28 of T-cell receptor.
Dong GC, Chuang PH, Chang KC, Jan PS, Hwang PI, Wu HB, Yi M, Zhou HX, Chen HM
Pharm Res. 2009
PubMed ID: 18989760
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Immunological aspects of chronic fatigue syndrome.
Lorusso L, Mikhaylova SV, Capelli E, Ferrari D, Ngonga GK, Ricevuti G
Autoimmun Rev. 2009
PubMed ID: 18801465
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Asthma and genes encoding components of the vitamin D pathway.
Bossé Y, Lemire M, Poon AH, Daley D, He JQ, Sandford A, White JH, James AL, Musk AW, Palmer LJ, Raby BA, Weiss ST, Kozyrskyj AL, Becker A, Hudson TJ, Laprise C
Respir Res. 2009
PubMed ID: 19852851
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In vivo proliferation of rat lamina propria T lymphocytes: general hyporesponsiveness but increased importance of the CD2 and CD28 pathways.
Hoffmann JC, Peters K, Pawlowski NN, Grollich K, Henschke S, Herrmann B, Zeitz M, Westermann J
Immunol Invest. 2009
PubMed ID: 19811406
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Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
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Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis.
Nolan A, Kobayashi H, Naveed B, Kelly A, Hoshino Y, Hoshino S, Karulf MR, Rom WN, Weiden MD, Gold JA
PLoS One. 2009
PubMed ID: 19672303
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CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo.
Shilling RA, Clay BS, Tesciuba AG, Berry EL, Lu T, Moore TV, Bandukwala HS, Tong J, Weinstock JV, Flavell RA, Horan T, Yoshinaga SK, Welcher AA, Cannon JL, Sperling AI
Cell Immunol. 2009
PubMed ID: 19646680
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Local network topology in human protein interaction data predicts functional association.
Li H, Liang S
PLoS One. 2009
PubMed ID: 19641626
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CD28 co-stimulation down regulates Th17 development.
Bouguermouh S, Fortin G, Baba N, Rubio M, Sarfati M
PLoS One. 2009
PubMed ID: 19333372
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Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity.
Wong SC, Tan AH, Lam KP
Cell Immunol. 2009
PubMed ID: 19249753
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4-1BBL costimulation retrieves CD28 expression in activated T cells.
Habib-Agahi M, Jaberipour M, Searle PF
Cell Immunol. 2009
PubMed ID: 19217084
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CD28 signaling in T regulatory precursors requires p56lck and rafts integrity to stabilize the Foxp3 message.
Nazarov-Stoica C, Surls J, Bona C, Casares S, Brumeanu TD
J Immunol. 2009
PubMed ID: 19109140
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Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody.
Freitas do Rosário AP, Muxel SM, Rodríguez-Málaga SM, Sardinha LR, Zago CA, Castillo-Méndez SI, Alvarez JM, D'Império Lima MR
J Immunol. 2008
PubMed ID: 19050251
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A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine.
Chen Q, Cannons JL, Paton JC, Akiba H, Schwartzberg PL, Snapper CM
J Immunol. 2008
PubMed ID: 19050242
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Persistent arthritis in Borrelia burgdorferi-infected HLA-DR4-positive CD28-negative mice post-antibiotic treatment.
Iliopoulou BP, Alroy J, Huber BT
Arthritis Rheum. 2008
PubMed ID: 19035513
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Signals and sequences that control CD28 localization to the central region of the immunological synapse.
Sanchez-Lockhart M, Graf B, Miller J
J Immunol. 2008
PubMed ID: 19017952
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CD28 stimulation triggers NF-kappaB activation through the CARMA1-PKCtheta-Grb2/Gads axis.
Takeda K, Harada Y, Watanabe R, Inutake Y, Ogawa S, Onuki K, Kagaya S, Tanabe K, Kishimoto H, Abe R
Int Immunol. 2008
PubMed ID: 18829987
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Protection from graft-versus-host disease with a novel B7 binding site-specific mouse anti-mouse CD28 monoclonal antibody.
Beyersdorf N, Ding X, Blank G, Dennehy KM, Kerkau T, Hünig T
Blood. 2008
PubMed ID: 18780833
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Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation.
Kim G, Turovskaya O, Levin M, Byrne FR, Whoriskey JS, McCabe JG, Kronenberg M
J Immunol. 2008
PubMed ID: 18832683
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The TSC-mTOR signaling pathway regulates the innate inflammatory response.
Weichhart T, Costantino G, Poglitsch M, Rosner M, Zeyda M, Stuhlmeier KM, Kolbe T, Stulnig TM, Hörl WH, Hengstschläger M, Müller M, Säemann MD
Immunity. 2008
PubMed ID: 18848473
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Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis.
Hao Z, Duncan GS, Seagal J, Su YW, Hong C, Haight J, Chen NJ, Elia A, Wakeham A, Li WY, Liepa J, Wood GA, Casola S, Rajewsky K, Mak TW
Immunity. 2008
PubMed ID: 18835195
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T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta.
Tseng SY, Waite JC, Liu M, Vardhana S, Dustin ML
J Immunol. 2008
PubMed ID: 18802089
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Superagonistic CD28 antibody induces donor-specific tolerance in rat renal allografts.
Azuma H, Isaka Y, Li X, Hünig T, Sakamoto T, Nohmi H, Takabatake Y, Mizui M, Kitazawa Y, Ichimaru N, Ibuki N, Ubai T, Inamoto T, Katsuoka Y, Takahara S
Am J Transplant. 2008
PubMed ID: 18727698
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CD28 down-regulation on CD4 T cells is a marker for graft dysfunction in lung transplant recipients.
Studer SM, George MP, Zhu X, Song Y, Valentine VG, Stoner MW, Sethi J, Steele C, Duncan SR
Am J Respir Crit Care Med. 2008
PubMed ID: 18617642
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[A study of costimulatory molecules in allergic allergic rhinitis patients].
Zhu R, Liu G, Li W, Wang Z, Chen H, Zhang W
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008
PubMed ID: 19086656
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Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3-kinase in primary peripheral T cells.
Gogishvili T, Elias F, Emery JL, McPherson K, Okkenhaug K, Hünig T, Dennehy KM
Eur J Immunol. 2008
PubMed ID: 18792405
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Expansion of CD4+CD28- T cells producing high levels of interferon-{gamma} in peripheral blood of patients with multiple sclerosis.
Miyazaki Y, Iwabuchi K, Kikuchi S, Fukazawa T, Niino M, Hirotani M, Sasaki H, Onoé K
Mult Scler. 2008
PubMed ID: 18573819
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CD28 costimulation is essential for human T regulatory expansion and function.
Golovina TN, Mikheeva T, Suhoski MM, Aqui NA, Tai VC, Shan X, Liu R, Balcarcel RR, Fisher N, Levine BL, Carroll RG, Warner N, Blazar BR, June CH, Riley JL
J Immunol. 2008
PubMed ID: 18684977
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CD28 controls differentiation of regulatory T cells from naive CD4 T cells.
Guo F, Iclozan C, Suh WK, Anasetti C, Yu XZ
J Immunol. 2008
PubMed ID: 18684917
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Investigation of CTLA-4 and CD28 gene polymorphisms in a group of Turkish patients with colorectal cancer.
Dilmec F, Ozgonul A, Uzunkoy A, Akkafa F
Int J Immunogenet. 2008
PubMed ID: 18680513
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CTLA4 expression is an indicator and regulator of steady-state CD4+ FoxP3+ T cell homeostasis.
Tang AL, Teijaro JR, Njau MN, Chandran SS, Azimzadeh A, Nadler SG, Rothstein DM, Farber DL
J Immunol. 2008
PubMed ID: 18641318
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Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3.
Zheng Y, Manzotti CN, Burke F, Dussably L, Qureshi O, Walker LS, Sansom DM
J Immunol. 2008
PubMed ID: 18641304
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Biphasic regulation of Il2 transcription in CD4+ T cells: roles for TNF-alpha receptor signaling and chromatin structure.
McKarns SC, Schwartz RH
J Immunol. 2008
PubMed ID: 18606681
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Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway.
Williams JA, Lumsden JM, Yu X, Feigenbaum L, Zhang J, Steinberg SM, Hodes RJ
J Immunol. 2008
PubMed ID: 18606642
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CD8+CD28-, suppressive T cells in systemic lupus erythematosus.
Tulunay A, Yavuz S, Direskeneli H, Eksioglu-Demiralp E
Lupus. 2008
PubMed ID: 18625635
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[Effects of Tongbi Mixture 2 on expressions of CD28 and CD152 and content of tumor necrosis factor-alpha in peripheral blood in rats with collagen-induced arthritis]
Liu H, Liu QP, Chen JF, Huang YM, Xu Q, Li SG
Zhong Xi Yi Jie He Xue Bao. 2008
PubMed ID: 18601859
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Fusions of dendritic cells with breast carcinoma stimulate the expansion of regulatory T cells while concomitant exposure to IL-12, CpG oligodeoxynucleotides, and anti-CD3/CD28 promotes the expansion of activated tumor reactive cells.
Vasir B, Wu Z, Crawford K, Rosenblatt J, Zarwan C, Bissonnette A, Kufe D, Avigan D
J Immunol. 2008
PubMed ID: 18566447
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Coligation of the hepatitis C virus receptor CD81 with CD28 primes naive T lymphocytes to acquire type 2 effector function.
Serra A, Nuti S, Tavarini S, Sammicheli C, Rosa D, Saletti G, Soldaini E, Abrignani S, Wack A
J Immunol. 2008
PubMed ID: 18566382
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New approach reveals CD28 and IFNG gene interaction in the susceptibility to cervical cancer.
Guzman VB, Yambartsev A, Goncalves-Primo A, Silva ID, Carvalho CR, Ribalta JC, Goulart LR, Shulzhenko N, Gerbase-Delima M, Morgun A
Hum Mol Genet. 2008
PubMed ID: 18337305
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CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription.
Schneider H, Rudd CE
Biochem Biophys Res Commun. 2008
PubMed ID: 18295596
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CD28 ligation in the absence of TCR promotes RelA/NF-kappaB recruitment and trans-activation of the HIV-1 LTR.
Annibaldi A, Sajeva A, Muscolini M, Ciccosanti F, Corazzari M, Piacentini M, Tuosto L
Eur J Immunol. 2008
PubMed ID: 18389481
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De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR.
Kang J, Huddleston SJ, Fraser JM, Khoruts A
J Leukoc Biol. 2008
PubMed ID: 18270248
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Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells.
Shi Z, Rifa'i M, Lee YH, Shiku H, Isobe K, Suzuki H
Immunology. 2008
PubMed ID: 18205792
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A blocking anti-CD28-specific antibody induces long-term heart allograft survival by suppression of the PKC theta-JNK signal pathway.
Jang MS, Pan F, Erickson LM, Fisniku O, Crews G, Wynn C, Hong IC, Tamura K, Kobayashi M, Jiang H
Transplantation. 2008
PubMed ID: 18408588
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ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival.
Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH
J Immunol. 2008
PubMed ID: 18390727
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Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling.
Alves NL, van Leeuwen EM, Derks IA, van Lier RA
J Immunol. 2008
PubMed ID: 18390701
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A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats.
Müller N, van den Brandt J, Odoardi F, Tischner D, Herath J, Flügel A, Reichardt HM
J Clin Invest. 2008
PubMed ID: 18357346
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Induction of antitumor immune response by homeostatic proliferation and CD28 signaling.
Suzuki T, Ogawa S, Tanabe K, Tahara H, Abe R, Kishimoto H
J Immunol. 2008
PubMed ID: 18354182
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Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.
Jacobs SR, Herman CE, Maciver NJ, Wofford JA, Wieman HL, Hammen JJ, Rathmell JC
J Immunol. 2008
PubMed ID: 18354169
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CD4+ICOS+ T lymphocytes inhibit T cell activation 'in vitro' and attenuate autoimmune encephalitis 'in vivo'.
Rojo JM, Pini E, Ojeda G, Bello R, Dong C, Flavell RA, Dianzani U, Portolés P
Int Immunol. 2008
PubMed ID: 18310064
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Regulation of CD28 expression on CD8+ T cells by CTLA-4.
Berg M, Zavazava N
J Leukoc Biol. 2008
PubMed ID: 18162511
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Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population.
Suwalska K, Pawlak E, Karabon L, Tomkiewicz A, Dobosz T, Urbaniak-Kujda D, Kuliczkowski K, Wolowiec D, Jedynak A, Frydecka I
Hum Immunol. 2008
PubMed ID: 18396212
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Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development.
Silvestri C, Narimatsu M, von Both I, Liu Y, Tan NB, Izzi L, McCaffery P, Wrana JL, Attisano L
Dev Cell. 2008
PubMed ID: 18331719
-
Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells.
Strainic MG, Liu J, Huang D, An F, Lalli PN, Muqim N, Shapiro VS, Dubyak GR, Heeger PS, Medof ME
Immunity. 2008
PubMed ID: 18328742
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T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice.
Jarmin SJ, David R, Ma L, Chai JG, Dewchand H, Takesono A, Ridley AJ, Okkenhaug K, Marelli-Berg FM
J Clin Invest. 2008
PubMed ID: 18259608
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Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking.
Barceló B, Pons J, Ferrer JM, Sauleda J, Fuster A, Agustí AG
Eur Respir J. 2008
PubMed ID: 18057064
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A critical role of costimulation during intrathymic development of invariant NK T cells.
Chung Y, Nurieva R, Esashi E, Wang YH, Zhou D, Gapin L, Dong C
J Immunol. 2008
PubMed ID: 18250436
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Homeostatic repopulation by CD28-CD8+ T cells in alemtuzumab-depleted kidney transplant recipients treated with reduced immunosuppression.
Trzonkowski P, Zilvetti M, Chapman S, Wieckiewicz J, Sutherland A, Friend P, Wood KJ
Am J Transplant. 2008
PubMed ID: 18211507
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Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.
Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T
Rheumatology (Oxford). 2008
PubMed ID: 18174230
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CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.
Garçon F, Patton DT, Emery JL, Hirsch E, Rottapel R, Sasaki T, Okkenhaug K
Blood. 2008
PubMed ID: 18006698
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CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis.
Nolan A, Weiden M, Kelly A, Hoshino Y, Hoshino S, Mehta N, Gold JA
Am J Respir Crit Care Med. 2008
PubMed ID: 17989345
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Control of memory CD8+ T cell differentiation by CD80/CD86-CD28 costimulation and restoration by IL-2 during the recall response.
Fuse S, Zhang W, Usherwood EJ
J Immunol. 2008
PubMed ID: 18178855
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Effect of moderate exercise training on T-helper cell subpopulations in elderly people.
Shimizu K, Kimura F, Akimoto T, Akama T, Tanabe K, Nishijima T, Kuno S, Kono I
Exerc Immunol Rev. 2008
PubMed ID: 19203082
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Modulation of NKT cell development by B7-CD28 interaction: an expanding horizon for costimulation.
Zheng X, Zhang H, Yin L, Wang CR, Liu Y, Zheng P
PLoS ONE. 2008
PubMed ID: 18628995
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Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation.
Pei Y, Zhu P, Dang Y, Wu J, Yang X, Wan B, Liu JO, Yi Q, Yu L
J Immunol. 2008
PubMed ID: 18097023
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Cutting edge: requirement for TRAF6 in the induction of T cell anergy.
King CG, Buckler JL, Kobayashi T, Hannah JR, Bassett G, Kim T, Pearce EL, Kim GG, Turka LA, Choi Y
J Immunol. 2008
PubMed ID: 18097000
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CD8+ T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections.
Heidema J, Lukens MV, van Maren WW, van Dijk ME, Otten HG, van Vught AJ, van der Werff DB, van Gestel SJ, Semple MG, Smyth RL, Kimpen JL, van Bleek GM
J Immunol. 2007
PubMed ID: 18056387
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CD28 deficiency exacerbates joint inflammation upon Borrelia burgdorferi infection, resulting in the development of chronic Lyme arthritis.
Iliopoulou BP, Alroy J, Huber BT
J Immunol. 2007
PubMed ID: 18056348
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The protective effect of CD8+CD28- T suppressor cells on the acute rejection responses in rat liver transplantation.
Liu Y, Chen N, Chen G, You P
Transplant Proc. 2007
PubMed ID: 18089392
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Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis.
Taleb S, Herbin O, Ait-Oufella H, Verreth W, Gourdy P, Barateau V, Merval R, Esposito B, Clément K, Holvoet P, Tedgui A, Mallat Z
Arterioscler Thromb Vasc Biol. 2007
PubMed ID: 17690315
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Memory CD8+ T cells require CD28 costimulation.
Borowski AB, Boesteanu AC, Mueller YM, Carafides C, Topham DJ, Altman JD, Jennings SR, Katsikis PD
J Immunol. 2007
PubMed ID: 17982038
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Requirements for selection of conventional and innate T lymphocyte lineages.
Horai R, Mueller KL, Handon RA, Cannons JL, Anderson SM, Kirby MR, Schwartzberg PL
Immunity. 2007
PubMed ID: 18031697
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Glucocorticoid-induced TNFR-related protein lowers the threshold of CD28 costimulation in CD8+ T cells.
Ronchetti S, Nocentini G, Bianchini R, Krausz LT, Migliorati G, Riccardi C
J Immunol. 2007
PubMed ID: 17947665
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Transforming growth factor beta-producing Foxp3(+)CD8(+)CD25(+) T cells induced by iris pigment epithelial cells display regulatory phenotype and acquire regulatory functions.
Sugita S, Futagami Y, Horie S, Mochizuki M
Exp Eye Res. 2007
PubMed ID: 17720157
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The role of CD8+CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand.
Ben-David H, Sharabi A, Dayan M, Sela M, Mozes E
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17956982
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Ras/PI3kinase/cofilin-independent activation of human CD45RA+ and CD45RO+ T cells by superagonistic CD28 stimulation.
Sester U, Wabnitz GH, Kirchgessner H, Samstag Y
Eur J Immunol. 2007
PubMed ID: 17899554
-
4-1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy.
Zhang H, Snyder KM, Suhoski MM, Maus MV, Kapoor V, June CH, Mackall CL
J Immunol. 2007
PubMed ID: 17878391
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CD8+ CD28- T regulatory lymphocytes inhibiting T cell proliferative and cytotoxic functions infiltrate human cancers.
Filaci G, Fenoglio D, Fravega M, Ansaldo G, Borgonovo G, Traverso P, Villaggio B, Ferrera A, Kunkl A, Rizzi M, Ferrera F, Balestra P, Ghio M, Contini P, Setti M, Olive D, Azzarone B, Carmignani G, Ravetti JL, Torre G, Indiveri F
J Immunol. 2007
PubMed ID: 17878327
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'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.
Park JH, Adoro S, Lucas PJ, Sarafova SD, Alag AS, Doan LL, Erman B, Liu X, Ellmeier W, Bosselut R, Feigenbaum L, Singer A
Nat Immunol. 2007
PubMed ID: 17873878
-
Genetic analyses of celiac disease in a Spanish population confirm association with CELIAC3 but not with CELIAC4.
Capilla A, Donat E, Planelles D, Espinós C, Ribes-Koninckx C, Palau F
Tissue Antigens. 2007
PubMed ID: 17767555
-
Impaired induction of CD27 and CD28 predicts naive CD4 T cell proliferation defects in HIV disease.
Luciano AA, Lederman MM, Valentin-Torres A, Bazdar DA, Sieg SF
J Immunol. 2007
PubMed ID: 17785788
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Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B
J Infect Dis. 2007
PubMed ID: 17703412
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[Role of CD28/CTLA-4 co-stimulators in immune pathophysiology of aplastic anemia]
He GS, Zhou L, Wu DP, Sun AN, Miao M, Wang XL, Chang WR, Zhu ZL, Jin ZM, Qiu HY, Tang XW, Fu ZZ, Han Y, Ma X, Chen SN, Wu XJ
Zhonghua Xue Ye Xue Za Zhi. 2007
PubMed ID: 18246813
-
Differential CD28 and inducible costimulatory molecule signaling requirements for protective CD4+ T-cell-mediated immunity against genital tract Chlamydia trachomatis infection.
Marks E, Verolin M, Stensson A, Lycke N
Infect Immun. 2007
PubMed ID: 17635872
-
Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase.
Shi M, Ye Z, Umeshappa KS, Moyana T, Xiang J
Biochem Biophys Res Commun. 2007
PubMed ID: 17618911
-
Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.
Tai X, Van Laethem F, Sharpe AH, Singer A
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17702861
-
Role of CD28 in fatal autoimmune disorder in scurfy mice.
Singh N, Chandler PR, Seki Y, Baban B, Takezaki M, Kahler DJ, Munn DH, Larsen CP, Mellor AL, Iwashima M
Blood. 2007
PubMed ID: 17463170
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Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells.
So T, Croft M
J Immunol. 2007
PubMed ID: 17641007
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A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes.
Nurieva RI, Chuvpilo S, Wieder ED, Elkon KB, Locksley R, Serfling E, Dong C
J Immunol. 2007
PubMed ID: 17617602
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Blockade of the 4-1BB (CD137)/4-1BBL and/or CD28/CD80/CD86 costimulatory pathways promotes corneal allograft survival in mice.
Asai T, Choi BK, Kwon PM, Kim WY, Kim JD, Vinay DS, Gebhardt BM, Kwon BS
Immunology. 2007
PubMed ID: 17376197
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OX40-mediated differentiation to effector function requires IL-2 receptor signaling but not CD28, CD40, IL-12Rbeta2, or T-bet.
Williams CA, Murray SE, Weinberg AD, Parker DC
J Immunol. 2007
PubMed ID: 17548606
-
Surface expression of fractalkine receptor (CX3CR1) on CD4+/CD28 T cells in RA patients and correlation with atherosclerotic damage.
Pingiotti E, Cipriani P, Marrelli A, Liakouli V, Fratini S, Penco M, Giacomelli R
Ann N Y Acad Sci. 2007
PubMed ID: 17804530
-
The CD28/CTLA-4-B7 signaling pathway is involved in both allergic sensitization and tolerance induction to orally administered peanut proteins.
van Wijk F, Nierkens S, de Jong W, Wehrens EJ, Boon L, van Kooten P, Knippels LM, Pieters R
J Immunol. 2007
PubMed ID: 17513738
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CD28-mediated regulation of multiple myeloma cell proliferation and survival.
Bahlis NJ, King AM, Kolonias D, Carlson LM, Liu HY, Hussein MA, Terebelo HR, Byrne GE, Levine BL, Boise LH, Lee KP
Blood. 2007
PubMed ID: 17311991
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Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras.
Komatsu N, Hori S
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17494743
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Pivotal advance: CTLA-4+ T cells exhibit normal antiviral functions during acute viral infection.
Raué HP, Slifka MK
J Leukoc Biol. 2007
PubMed ID: 17215523
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Enhanced NFATc1 nuclear occupancy causes T cell activation independent of CD28 costimulation.
Pan M, Winslow MM, Chen L, Kuo A, Felsher D, Crabtree GR
J Immunol. 2007
PubMed ID: 17371988
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Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28.
Mirenda V, Jarmin SJ, David R, Dyson J, Scott D, Gu Y, Lechler RI, Okkenhaug K, Marelli-Berg FM
Blood. 2007
PubMed ID: 17119120
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Capture of target cell membrane components via trogocytosis is triggered by a selected set of surface molecules on T or B cells.
Hudrisier D, Aucher A, Puaux AL, Bordier C, Joly E
J Immunol. 2007
PubMed ID: 17339461
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Human immunodeficiency virus (HIV) type 1 Vpr induces differential regulation of T cell costimulatory molecules: direct effect of Vpr on T cell activation and immune function.
Venkatachari NJ, Majumder B, Ayyavoo V
Virology. 2007
PubMed ID: 17023015
-
Analysis of CD28 and CTLA-4 gene polymorphisms in Turkish patients with Behcet's disease.
Gunesacar R, Erken E, Bozkurt B, Ozer HT, Dinkci S, Erken EG, Ozbalkan Z
Int J Immunogenet. 2007
PubMed ID: 17284227
-
Mitogenic CD28 signals require the exchange factor Vav1 to enhance TCR signaling at the SLP-76-Vav-Itk signalosome.
Dennehy KM, Elias F, Na SY, Fischer KD, Hünig T, Lühder F
J Immunol. 2007
PubMed ID: 17237383
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Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells.
Badour K, McGavin MK, Zhang J, Freeman S, Vieira C, Filipp D, Julius M, Mills GB, Siminovitch KA
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242350
-
Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes.
Butty V, Roy M, Sabeti P, Besse W, Benoist C, Mathis D
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17197413
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The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes.
Song J, Salek-Ardakani S, So T, Croft M
Nat Immunol. 2007
PubMed ID: 17128276
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4-1BB (CD137) signals depend upon CD28 signals in alloimmune responses.
Lee EA, Kim JE, Seo JH, Kwon BS, Nam SH, Kwon B, Cho HR
Exp Mol Med. 2006
PubMed ID: 17202836
-
Differential requirement for CD28 and CD80/86 pathways of costimulation in the long-term control of murine gammaherpesvirus-68.
Lyon AB, Sarawar SR
Virology. 2006
PubMed ID: 16934307
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The interchain disulfide linkage is not a prerequisite but enhances CD28 costimulatory function.
Lazar-Molnar E, Almo SC, Nathenson SG
Cell Immunol. 2006
PubMed ID: 17467674
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B7+ iris pigment epithelial cells convert T cells into CTLA-4+, B7-expressing CD8+ regulatory T cells.
Sugita S, Keino H, Futagami Y, Takase H, Mochizuki M, Stein-Streilein J, Streilein JW
Invest Ophthalmol Vis Sci. 2006
PubMed ID: 17122127
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Direct CD28 costimulation is required for CD8+ T cell-mediated resistance to an acute viral disease in a natural host.
Fang M, Sigal LJ
J Immunol. 2006
PubMed ID: 17114476
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Gut IgA class switch recombination in the absence of CD40 does not occur in the lamina propria and is independent of germinal centers.
Bergqvist P, Gärdby E, Stensson A, Bemark M, Lycke NY
J Immunol. 2006
PubMed ID: 17114448
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CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse.
Tavano R, Contento RL, Baranda SJ, Soligo M, Tuosto L, Manes S, Viola A
Nat Cell Biol. 2006
PubMed ID: 17060905
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CD28 ligation costimulates cell death but not maturation of double-positive thymocytes due to defective ERK MAPK signaling.
Graham DB, Bell MP, Huntoon CJ, Griffin MD, Tai X, Singer A, McKean DJ
J Immunol. 2006
PubMed ID: 17056536
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The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation.
Gelman AE, LaRosa DF, Zhang J, Walsh PT, Choi Y, Sunyer JO, Turka LA
Immunity. 2006
PubMed ID: 17055754
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The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells.
Okkenhaug K, Patton DT, Bilancio A, Garçon F, Rowan WC, Vanhaesebroeck B
J Immunol. 2006
PubMed ID: 17015696
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Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression.
Charvet C, Canonigo AJ, Bécart S, Maurer U, Miletic AV, Swat W, Deckert M, Altman A
J Immunol. 2006
PubMed ID: 17015685
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BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes.
Cismasiu VB, Ghanta S, Duque J, Albu DI, Chen HM, Kasturi R, Avram D
Blood. 2006
PubMed ID: 16809611
-
A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant.
Friend LD, Shah DD, Deppong C, Lin J, Bricker TL, Juehne TI, Rose CM, Green JM
J Exp Med. 2006
PubMed ID: 16908623
-
CD28 costimulation mediates transcription of SKP2 and CKS1, the substrate recognition components of SCFSkp2 ubiquitin ligase that leads p27kip1 to degradation.
Appleman LJ, Chernova I, Li L, Boussiotis VA
Cell Cycle. 2006
PubMed ID: 16969077
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CD80 and CD86 control antiviral CD8+ T-cell function and immune surveillance of murine gammaherpesvirus 68.
Fuse S, Obar JJ, Bellfy S, Leung EK, Zhang W, Usherwood EJ
J Virol. 2006
PubMed ID: 16940527
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Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation.
Watanabe R, Harada Y, Takeda K, Takahashi J, Ohnuki K, Ogawa S, Ohgai D, Kaibara N, Koiwai O, Tanabe K, Toma H, Sugamura K, Abe R
J Immunol. 2006
PubMed ID: 16818765
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CD28-stimulated ERK2 phosphorylation is required for polarization of the microtubule organizing center and granules in YTS NK cells.
Chen X, Allan DS, Krzewski K, Ge B, Kopcow H, Strominger JL
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16801532
-
Duration of CTL activation regulates IL-2 production required for autonomous clonal expansion.
Spierings DC, Lemmens EE, Grewal K, Schoenberger SP, Green DR
Eur J Immunol. 2006
PubMed ID: 16791878
-
Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells.
Yu XZ, Liang Y, Nurieva RI, Guo F, Anasetti C, Dong C
J Immunol. 2006
PubMed ID: 16751384
-
T-cell tolerance or function is determined by combinatorial costimulatory signals.
Nurieva R, Thomas S, Nguyen T, Martin-Orozco N, Wang Y, Kaja MK, Yu XZ, Dong C
EMBO J. 2006
PubMed ID: 16724117
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Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression.
Oderup C, Cederbom L, Makowska A, Cilio CM, Ivars F
Immunology. 2006
PubMed ID: 16771859
-
Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86.
Manzotti CN, Liu MK, Burke F, Dussably L, Zheng Y, Sansom DM
Eur J Immunol. 2006
PubMed ID: 16708397
-
No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis.
Wiencke K, Boberg KM, Donaldson P, Harbo H, Ling V, Schrumpf E, Spurkland A
Scand J Gastroenterol. 2006
PubMed ID: 16638702
-
Expression of CD28 and cytotoxic T lymphocyte antigen 4 at the maternal-fetal interface in women with unexplained pregnancy loss.
Wang X, Ma Z, Hong Y, Lu P, Lin Q
Int J Gynaecol Obstet. 2006
PubMed ID: 16564528
-
Engagement of CD28 outside of the immunological synapse results in up-regulation of IL-2 mRNA stability but not IL-2 transcription.
Sanchez-Lockhart M, Miller J
J Immunol. 2006
PubMed ID: 16585571
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Expression level of costimulatory receptor ICOS is critical for determining the polarization of helper T cell function.
Watanabe S, Ogawa S, Hara Y, Tanabe K, Toma H, Abe R
Transpl Immunol. 2006
PubMed ID: 16635747
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Cutting Edge: CD28 controls dominant regulatory T cell activity during active immunization.
Lyddane C, Gajewska BU, Santos E, King PD, Furtado GC, Sadelain M
J Immunol. 2006
PubMed ID: 16517696
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Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells.
Delogu A, Schebesta A, Sun Q, Aschenbrenner K, Perlot T, Busslinger M
Immunity. 2006
PubMed ID: 16546096
-
Role for the CD28 molecule in the control of Coxiella burnetii infection.
Honstettre A, Meghari S, Nunès JA, Lepidi H, Raoult D, Olive D, Mege JL
Infect Immun. 2006
PubMed ID: 16495554
-
Quantitative analysis of phosphotyrosine signaling networks triggered by CD3 and CD28 costimulation in Jurkat cells.
Kim JE, White FM
J Immunol. 2006
PubMed ID: 16493040
-
IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3.
Owaki T, Asakawa M, Kamiya S, Takeda K, Fukai F, Mizuguchi J, Yoshimoto T
J Immunol. 2006
PubMed ID: 16493033
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Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin.
Colombetti S, Basso V, Mueller DL, Mondino A
J Immunol. 2006
PubMed ID: 16493028
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Natural regulatory T cells control the development of atherosclerosis in mice.
Ait-Oufella H, Salomon BL, Potteaux S, Robertson AK, Gourdy P, Zoll J, Merval R, Esposito B, Cohen JL, Fisson S, Flavell RA, Hansson GK, Klatzmann D, Tedgui A, Mallat Z
Nat Med. 2006
PubMed ID: 16462800
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Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection.
Kemball CC, Lee ED, Szomolanyi-Tsuda E, Pearson TC, Larsen CP, Lukacher AE
J Immunol. 2006
PubMed ID: 16424212
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Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism.
Montagnoli C, Fallarino F, Gaziano R, Bozza S, Bellocchio S, Zelante T, Kurup WP, Pitzurra L, Puccetti P, Romani L
J Immunol. 2006
PubMed ID: 16424201
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Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo.
Wohlfert EA, Gorelik L, Mittler R, Flavell RA, Clark RB
J Immunol. 2006
PubMed ID: 16424156
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Ex vivo expanded umbilical cord blood T cells maintain naive phenotype and TCR diversity.
Parmar S, Robinson SN, Komanduri K, St John L, Decker W, Xing D, Yang H, McMannis J, Champlin R, de Lima M, Molldrem J, Rieber A, Bonyhadi M, Berenson R, Shpall EJ
Cytotherapy. 2006
PubMed ID: 16698688
-
Modelling thymic HIV-1 Nef effects.
Stove V, Verhasselt B
Curr HIV Res. 2006
PubMed ID: 16454711
-
CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium.
Bry L, Brigl M, Brenner MB
Infect Immun. 2006
PubMed ID: 16369024
-
B7+ iris pigment epithelium induce CD8+ T regulatory cells; both suppress CTLA-4+ T cells.
Sugita S, Ng TF, Lucas PJ, Gress RE, Streilein JW
J Immunol. 2006
PubMed ID: 16365402
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Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
-
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.
Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA
Nat Immunol. 2006
PubMed ID: 16311599
-
Haplotypes in the CTLA4 region are associated with coeliac disease in the Irish population.
Brophy K, Ryan AW, Thornton JM, Abuzakouk M, Fitzgerald AP, McLoughlin RM, O'morain C, Kennedy NP, Stevens FM, Feighery C, Kelleher D, McManus R
Genes Immun. 2006
PubMed ID: 16237465
-
Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells.
Kovacs B, Parry RV, Ma Z, Fan E, Shivers DK, Freiberg BA, Thomas AK, Rutherford R, Rumbley CA, Riley JL, Finkel TH
J Immunol. 2005
PubMed ID: 16339520
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CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4+ T cells in vivo.
Fukada K, Koyanagi M, Arimura Y, Ogiuchi H, Uchiyama T, Yagi J
Cell Immunol. 2005
PubMed ID: 16600196
-
Cooperation between 4-1BB and ICOS in the immune response to influenza virus revealed by studies of CD28/ICOS-deficient mice.
Vidric M, Suh WK, Dianzani U, Mak TW, Watts TH
J Immunol. 2005
PubMed ID: 16301634
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Early kinetic window of target T cell susceptibility to CD25+ regulatory T cell activity.
Sojka DK, Hughson A, Sukiennicki TL, Fowell DJ
J Immunol. 2005
PubMed ID: 16301632
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The carboxyl-terminal segment of the adaptor protein ALX directs its nuclear export during T cell activation.
Shapiro MJ, Chen YY, Shapiro VS
J Biol Chem. 2005
PubMed ID: 16169852
-
Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.
Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY
Cell Res. 2005
PubMed ID: 16354571
-
Differential cytokine production and Toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae.
van der Graaf CA, Netea MG, Verschueren I, van der Meer JW, Kullberg BJ
Infect Immun. 2005
PubMed ID: 16239547
-
CD28 is required for optimal induction, but not maintenance, of vaccine-induced immunity to Blastomyces dermatitidis.
Wüthrich M, Warner T, Klein BS
Infect Immun. 2005
PubMed ID: 16239544
-
Virus attachment and replication are promoted after acquisition of host CD28 and CD152 by HIV-1.
Giguere JF, Diou J, Madrenas J, Tremblay MJ
J Infect Dis. 2005
PubMed ID: 16136471
-
Differential requirement for CD28/CTLA-4-CD80/CD86 interactions in drug-induced type 1 and type 2 immune responses to trinitrophenyl-ovalbumin.
Nierkens S, Aalbers M, Bol M, Bleumink R, van Kooten P, Boon L, Pieters R
J Immunol. 2005
PubMed ID: 16148116
-
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
-
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
-
Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulation.
Markiewicz MA, Carayannopoulos LN, Naidenko OV, Matsui K, Burack WR, Wise EL, Fremont DH, Allen PM, Yokoyama WM, Colonna M, Shaw AS
J Immunol. 2005
PubMed ID: 16116168
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The role of suppressor of cytokine signaling 1 as a negative regulator for aberrant expansion of CD8alpha+ dendritic cell subset.
Tsukada J, Ozaki A, Hanada T, Chinen T, Abe R, Yoshimura A, Kubo M
Int Immunol. 2005
PubMed ID: 16091384
-
Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients.
Lorentzen AR, Celius EG, Ekstrøm PO, Wiencke K, Lie BA, Myhr KM, Ling V, Thorsby E, Vartdal F, Spurkland A, Harbo HF
J Neuroimmunol. 2005
PubMed ID: 16005527
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The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.
Akiba H, Takeda K, Kojima Y, Usui Y, Harada N, Yamazaki T, Ma J, Tezuka K, Yagita H, Okumura K
J Immunol. 2005
PubMed ID: 16081804
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Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.
Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, Watts JD, Hood L, Aebersold R
Nat Methods. 2005
PubMed ID: 16094384
-
Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis.
Beyersdorf N, Gaupp S, Balbach K, Schmidt J, Toyka KV, Lin CH, Hanke T, Hünig T, Kerkau T, Gold R
J Exp Med. 2005
PubMed ID: 16061730
-
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection.
Loke P, Zang X, Hsuan L, Waitz R, Locksley RM, Allen JE, Allison JP
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15994233
-
Characterization of CD28, CTLA4, and ICOS polymorphisms in three Brazilian ethnic groups.
Guzman VB, Morgun A, Shulzhenko N, Mine KL, Gonçalves-Primo A, Musatti CC, Gerbase-Delima M
Hum Immunol. 2005
PubMed ID: 16112024
-
Genetic analysis of the 2q33 region containing CD28-CTLA4-ICOS genes: association with non-Hodgkin's lymphoma.
Piras G, Monne M, Uras A, Palmas A, Murineddu M, Arru L, Bianchi A, Calvisi A, Curreli L, Gaviano E, Lai P, Murgia A, Latte GC, Noli A, Gabbas A
Br J Haematol. 2005
PubMed ID: 15953005
-
Signals from CD28 induce stable epigenetic modification of the IL-2 promoter.
Thomas RM, Gao L, Wells AD
J Immunol. 2005
PubMed ID: 15814687
-
Itk is not essential for CD28 signaling in naive T cells.
Li CR, Berg LJ
J Immunol. 2005
PubMed ID: 15814667
-
Immunosuppressive and autoimmune effects of thimerosal in mice.
Havarinasab S, Häggqvist B, Björn E, Pollard KM, Hultman P
Toxicol Appl Pharmacol. 2005
PubMed ID: 15808517
-
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
Nature. 2005
PubMed ID: 15815621
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Cutting edge: p27Kip1 deficiency reduces the requirement for CD28-mediated costimulation in naive CD8+ but not CD4+ T lymphocytes.
Wolfraim LA, Letterio JJ
J Immunol. 2005
PubMed ID: 15728451
-
Crystal structure of a soluble CD28-Fab complex.
Evans EJ, Esnouf RM, Manso-Sancho R, Gilbert RJ, James JR, Yu C, Fennelly JA, Vowles C, Hanke T, Walse B, Hünig T, Sørensen P, Stuart DI, Davis SJ
Nat Immunol. 2005
PubMed ID: 15696168
-
T cells modulate neutrophil-dependent acute renal failure during endotoxemia: critical role for CD28.
Singbartl K, Bockhorn SG, Zarbock A, Schmolke M, Van Aken H
J Am Soc Nephrol. 2005
PubMed ID: 15689402
-
T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells.
Purtic B, Pitcher LA, van Oers NS, Wülfing C
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15703298
-
ICOS costimulates invariant NKT cell activation.
Kaneda H, Takeda K, Ota T, Kaduka Y, Akiba H, Ikarashi Y, Wakasugi H, Kronenberg M, Kinoshita K, Yagita H, Okumura K
Biochem Biophys Res Commun. 2005
PubMed ID: 15629449
-
Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b.
Krawczyk CM, Jones RG, Atfield A, Bachmaier K, Arya S, Odermatt B, Ohashi PS, Penninger JM
J Immunol. 2005
PubMed ID: 15661906
-
CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo.
Yamada A, Salama AD, Sho M, Najafian N, Ito T, Forman JP, Kewalramani R, Sandner S, Harada H, Clarkson MR, Mandelbrot DA, Sharpe AH, Oshima H, Yagita H, Chalasani G, Lakkis FG, Auchincloss H, Sayegh MH
J Immunol. 2005
PubMed ID: 15661893
-
A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection.
Vacchio MS, Williams JA, Hodes RJ
Eur J Immunol. 2005
PubMed ID: 15657954
-
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.
Tai X, Cowan M, Feigenbaum L, Singer A
Nat Immunol. 2005
PubMed ID: 15640801
-
Requirement for CD28 may not be absolute for collagen-induced arthritis: study with HLA-DQ8 transgenic mice.
Taneja V, Taneja N, Behrens M, Griffiths MM, Luthra HS, David CS
J Immunol. 2005
PubMed ID: 15634938
-
Role of CD28 in polyclonal and specific T and B cell responses required for protection against blood stage malaria.
Elias RM, Sardinha LR, Bastos KR, Zago CA, da Silva AP, Alvarez JM, Lima MR
J Immunol. 2005
PubMed ID: 15634900
-
Role for protein kinase Ctheta (PKCtheta) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-kappaB activation.
Li Y, Sedwick CE, Hu J, Altman A
J Biol Chem. 2005
PubMed ID: 15536066
-
Expression of CD28 and CTLA4 on T cells in bone morrow of immune-mediated aplastic anemia mice.
Liu Z, Sun H, Liu W, Luo X, He L, Xu H
J Huazhong Univ Sci Technolog Med Sci. 2005
PubMed ID: 16463658
-
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
-
CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway.
Wu LX, La Rose J, Chen L, Neale C, Mak T, Okkenhaug K, Wange R, Rottapel R
J Immunol. 2005
PubMed ID: 15611240
-
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ
Nat Biotechnol. 2005
PubMed ID: 15592455
-
Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.
Li D, Gál I, Vermes C, Alegre ML, Chong AS, Chen L, Shao Q, Adarichev V, Xu X, Koreny T, Mikecz K, Finnegan A, Glant TT, Zhang J
J Immunol. 2004
PubMed ID: 15585834
-
Cutting edge: CD28-mediated transcriptional and posttranscriptional regulation of IL-2 expression are controlled through different signaling pathways.
Sanchez-Lockhart M, Marin E, Graf B, Abe R, Harada Y, Sedwick CE, Miller J
J Immunol. 2004
PubMed ID: 15585831
-
High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy.
Huxley P, Sutton DH, Debnam P, Matthews IR, Brewer JE, Rose J, Trickett M, Williams DD, Andersen TB, Classon BJ
Chem Biol. 2004
PubMed ID: 15610849
-
Characterization of Lck-binding elements in the herpesviral regulatory Tip protein.
Bauer F, Hofinger E, Hoffmann S, Rösch P, Schweimer K, Sticht H
Biochemistry. 2004
PubMed ID: 15554700
-
Toll-dependent control mechanisms of CD4 T cell activation.
Pasare C, Medzhitov R
Immunity. 2004
PubMed ID: 15539158
-
Costimulation requirements of induced murine systemic autoimmune disease.
Pollard KM, Arnush M, Hultman P, Kono DH
J Immunol. 2004
PubMed ID: 15494542
-
CD28 and lipid rafts coordinate recruitment of Lck to the immunological synapse of human T lymphocytes.
Tavano R, Gri G, Molon B, Marinari B, Rudd CE, Tuosto L, Viola A
J Immunol. 2004
PubMed ID: 15494485
-
CD28 is required for T cell activation and IFN-gamma production by CD4+ and CD8+ T cells in response to Trypanosoma cruzi infection.
Martins GA, Campanelli AP, Silva RB, Tadokoro CE, Russo M, Cunha FQ, Rizzo LV, Silva JS
Microbes Infect. 2004
PubMed ID: 15488732
-
Effects of double blockade of CD28 and inducible-costimulator signaling on anti-glomerular basement membrane glomerulonephritis.
Okano K, Nitta K, Ogawa S, Horita S, Habiro K, Nihei H, Abe R
J Lab Clin Med. 2004
PubMed ID: 15514586
-
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
-
CD28 costimulation is required for the expression of T-cell-dependent cell-mediated immunity against blood-stage Plasmodium chabaudi malaria parasites.
Rummel T, Batchelder J, Flaherty P, LaFleur G, Nanavati P, Burns JM, Weidanz WP
Infect Immun. 2004
PubMed ID: 15385476
-
A new role for CD28 in the survival of autoreactive T cells in the periphery after chronic exposure to autoantigen.
Gao JX, Chang X, Zheng X, Wen J, Yin L, Du P, Zheng P, Liu Y
Int Immunol. 2004
PubMed ID: 15314039
-
CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1.
Ohnuma K, Yamochi T, Uchiyama M, Nishibashi K, Yoshikawa N, Shimizu N, Iwata S, Tanaka H, Dang NH, Morimoto C
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15353589
-
The ALX Src homology 2 domain is both necessary and sufficient to inhibit T cell receptor/CD28-mediated up-regulation of RE/AP.
Shapiro MJ, Powell P, Ndubuizu A, Nzerem C, Shapiro VS
J Biol Chem. 2004
PubMed ID: 15284240
-
A role for CD28 in lymphopenia-induced proliferation of CD4 T cells.
Hagen KA, Moses CT, Drasler EF, Podetz-Pedersen KM, Jameson SC, Khoruts A
J Immunol. 2004
PubMed ID: 15356139
-
CD28 activation does not down-regulate Cbl-b expression in aged rat T-lymphocytes.
Xu Z, George C, Jolly CA
Mech Ageing Dev. 2004
PubMed ID: 15491677
-
B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse.
Pentcheva-Hoang T, Egen JG, Wojnoonski K, Allison JP
Immunity. 2004
PubMed ID: 15357951
-
B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8- T cells in the thymus.
Zheng X, Gao JX, Chang X, Wang Y, Liu Y, Wen J, Zhang H, Zhang J, Liu Y, Zheng P
J Immunol. 2004
PubMed ID: 15294937
-
Translocation of CD28 to lipid rafts and costimulation of IL-2.
Sadra A, Cinek T, Imboden JB
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15280538
-
B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells.
Ng LG, Sutherland AP, Newton R, Qian F, Cachero TG, Scott ML, Thompson JS, Wheway J, Chtanova T, Groom J, Sutton IJ, Xin C, Tangye SG, Kalled SL, Mackay F, Mackay CR
J Immunol. 2004
PubMed ID: 15240667
-
Tumor necrosis factor-alpha and CD80 modulate CD28 expression through a similar mechanism of T-cell receptor-independent inhibition of transcription.
Lewis DE, Merched-Sauvage M, Goronzy JJ, Weyand CM, Vallejo AN
J Biol Chem. 2004
PubMed ID: 15128741
-
The SH3 domain of Tec kinase is essential for its targeting to activated CD28 costimulatory molecule.
Garçon F, Ghiotto M, Gérard A, Yang WC, Olive D, Nunès JA
Eur J Immunol. 2004
PubMed ID: 15214045
-
Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease.
Liu Q, Arseculeratne C, Liu Z, Whitmire J, Grusby MJ, Finkelman FD, Darling TN, Cheever AW, Swearengen J, Urban JF, Gause WC
Infect Immun. 2004
PubMed ID: 15213110
-
Requirement for CD28 in the effector phase of allergic airway inflammation.
Kimzey SL, Liu P, Green JM
J Immunol. 2004
PubMed ID: 15210826
-
Different costimulatory and growth factor requirements for CD4+ and CD8+ T cell-mediated rejection.
Vu MD, Amanullah F, Li Y, Demirci G, Sayegh MH, Li XC
J Immunol. 2004
PubMed ID: 15210777
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Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors.
Kirchhoff F, Schindler M, Bailer N, Renkema GH, Saksela K, Knoop V, Müller-Trutwin MC, Santiago ML, Bibollet-Ruche F, Dittmar MT, Heeney JL, Hahn BH, Münch J
J Virol. 2004
PubMed ID: 15194762
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CD27 is acquired by primed B cells at the centroblast stage and promotes germinal center formation.
Xiao Y, Hendriks J, Langerak P, Jacobs H, Borst J
J Immunol. 2004
PubMed ID: 15187121
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CD28 disruption exacerbates inflammation in Tgf-beta1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-beta1.
Mamura M, Lee W, Sullivan TJ, Felici A, Sowers AL, Allison JP, Letterio JJ
Blood. 2004
PubMed ID: 15016653
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CD28 costimulation controls histone hyperacetylation of the interleukin 5 gene locus in developing th2 cells.
Inami M, Yamashita M, Tenda Y, Hasegawa A, Kimura M, Hashimoto K, Seki N, Taniguchi M, Nakayama T
J Biol Chem. 2004
PubMed ID: 15039422
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Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC
Anal Chem. 2004
PubMed ID: 15144186
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The inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of CD28.
Suh WK, Tafuri A, Berg-Brown NN, Shahinian A, Plyte S, Duncan GS, Okada H, Wakeham A, Odermatt B, Ohashi PS, Mak TW
J Immunol. 2004
PubMed ID: 15128772
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CD28 signals in the immature immunological synapse.
Andres PG, Howland KC, Dresnek D, Edmondson S, Abbas AK, Krummel MF
J Immunol. 2004
PubMed ID: 15128767
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Regulation of postsurgical fibrosis by the programmed death-1 inhibitory pathway.
Holsti MA, Chitnis T, Panzo RJ, Bronson RT, Yagita H, Sayegh MH, Tzianabos AO
J Immunol. 2004
PubMed ID: 15100324
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CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-kappaB subunits on IL-8 and Bcl-xL gene promoters.
Marinari B, Costanzo A, Marzano V, Piccolella E, Tuosto L
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15079071
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The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells.
Mikolajczak SA, Ma BY, Yoshida T, Yoshida R, Kelvin DJ, Ochi A
J Exp Med. 2004
PubMed ID: 15067037
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HIV accessory proteins and surviving the host cell.
Anderson JL, Hope TJ
Curr HIV/AIDS Rep. 2004
PubMed ID: 16091223
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HIV/SIV escape from immune surveillance: focus on Nef.
Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M
Curr HIV Res. 2004
PubMed ID: 15078178
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High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
Genome Res. 2004
PubMed ID: 15060019
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
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CTLA-4+CD8+ T cells that encounter B7-2+ iris pigment epithelial cells express their own B7-2 to achieve global suppression of T cell activation.
Sugita S, Ng TF, Schwartzkopff J, Streilein JW
J Immunol. 2004
PubMed ID: 15034031
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Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation.
Andres PG, Howland KC, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A, Abbas AK
Nat Immunol. 2004
PubMed ID: 15004555
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PKCtheta signals activation versus tolerance in vivo.
Berg-Brown NN, Gronski MA, Jones RG, Elford AR, Deenick EK, Odermatt B, Littman DR, Ohashi PS
J Exp Med. 2004
PubMed ID: 15024044
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Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients.
Teutsch SM, Booth DR, Bennetts BH, Heard RN, Stewart GJ
J Neuroimmunol. 2004
PubMed ID: 14975605
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Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins.
Heissmeyer V, Macián F, Im SH, Varma R, Feske S, Venuprasad K, Gu H, Liu YC, Dustin ML, Rao A
Nat Immunol. 2004
PubMed ID: 14973438
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Resistance of single-positive thymocytes to glucocorticoid-induced apoptosis is mediated by CD28 signaling.
van den Brandt J, Wang D, Reichardt HM
Mol Endocrinol. 2004
PubMed ID: 14701943
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Schistosoma mansoni PIII antigen modulates in vitro granuloma formation by regulating CD28, CTLA-4, and CD86 expression in humans.
Zouain CS, Falcão PL, Goes TS, Leite MF, Goes AM
Immunol Lett. 2004
PubMed ID: 15019278
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High avidity CD8+ T cells generated from CD28-deficient or wildtype mice exhibit a differential dependence on lipid raft integrity for activation.
Cawthon AG, Kroger CJ, Alexander-Miller MA
Cell Immunol. 2004
PubMed ID: 15135297
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Lack of CD28 expression on HIV-specific cytotoxic T lymphocytes is associated with disease progression.
Gamberg J, Pardoe I, Bowmer MI, Howley C, Grant M
Immunol Cell Biol. 2004
PubMed ID: 14984593
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Critical role of OX40 in CD28 and CD154-independent rejection.
Demirci G, Amanullah F, Kewalaramani R, Yagita H, Strom TB, Sayegh MH, Li XC
J Immunol. 2004
PubMed ID: 14734751
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A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo.
Bertram EM, Dawicki W, Sedgmen B, Bramson JL, Lynch DH, Watts TH
J Immunol. 2004
PubMed ID: 14707071
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CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis.
Sempowski GD, Cross SJ, Heinly CS, Scearce RM, Haynes BF
J Immunol. 2004
PubMed ID: 14707048
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
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Identification of a murine CD28 dileucine motif that suppresses single-chain chimeric T-cell receptor expression and function.
Nguyen P, Moisini I, Geiger TL
Blood. 2003
PubMed ID: 12946999
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The expansion of CD4+CD28- T cells in patients with chronic kidney graft rejection.
Pawlik A, Florczak M, Masiuk M, Dutkiewicz G, Machalinski B, Rozanski J, Domanski L, Gawrońska-Szklarz B
Transplant Proc. 2003
PubMed ID: 14697933
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Differential regulation of peripheral CD4+ T cell tolerance induced by deletion and TCR revision.
Ali M, Weinreich M, Balcaitis S, Cooper CJ, Fink PJ
J Immunol. 2003
PubMed ID: 14634147
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Cloning and characterization of ALX, an adaptor downstream of CD28.
Greene TA, Powell P, Nzerem C, Shapiro MJ, Shapiro VS
J Biol Chem. 2003
PubMed ID: 12960172
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CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool.
Hendriks J, Xiao Y, Borst J
J Exp Med. 2003
PubMed ID: 14581610
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PI3-kinase and MAP-kinase signaling cascades in AILIM/ICOS- and CD28-costimulated T-cells have distinct functions between cell proliferation and IL-10 production.
Okamoto N, Tezuka K, Kato M, Abe R, Tsuji T
Biochem Biophys Res Commun. 2003
PubMed ID: 14550257
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Regulatory functions of CD8+CD28- T cells in an autoimmune disease model.
Najafian N, Chitnis T, Salama AD, Zhu B, Benou C, Yuan X, Clarkson MR, Sayegh MH, Khoury SJ
J Clin Invest. 2003
PubMed ID: 14523041
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Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells.
Tang Q, Henriksen KJ, Boden EK, Tooley AJ, Ye J, Subudhi SK, Zheng XX, Strom TB, Bluestone JA
J Immunol. 2003
PubMed ID: 14500627
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Constitutive expression of a costimulatory ligand on antigen-presenting cells in the nervous system drives demyelinating disease.
Zehntner SP, Brisebois M, Tran E, Owens T, Fournier S
FASEB J. 2003
PubMed ID: 12923072
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Mechanism of allorecognition and skin graft rejection in CD28 and CD40 ligand double-deficient mice.
Habiro K, Kotani M, Omoto K, Kobayashi S, Tanabe K, Shimmura H, Suzuki K, Hayashi T, Toma H, Abe R
Transplantation. 2003
PubMed ID: 14501867
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Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production.
Topp MS, Riddell SR, Akatsuka Y, Jensen MC, Blattman JN, Greenberg PD
J Exp Med. 2003
PubMed ID: 12963692
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Cutting Edge: Multiple autoimmune pathways in kd/kd mice.
Hancock WW, Tsai TL, Madaio MP, Gasser DL
J Immunol. 2003
PubMed ID: 12960297
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CD28-dependent HIV-1 transcription is associated with Vav, Rac, and NF-kappa B activation.
Cook JA, Albacker L, August A, Henderson AJ
J Biol Chem. 2003
PubMed ID: 12842899
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CD28 costimulation independence of target organ versus circulating memory antigen-specific CD4+ T cells.
Fontenot AP, Gharavi L, Bennett SR, Canavera SJ, Newman LS, Kotzin BL
J Clin Invest. 2003
PubMed ID: 12952926
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CD28 engagement promotes actin polymerization through the activation of the small Rho GTPase Cdc42 in human T cells.
Salazar-Fontana LI, Barr V, Samelson LE, Bierer BE
J Immunol. 2003
PubMed ID: 12928366
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The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses.
Suh WK, Gajewska BU, Okada H, Gronski MA, Bertram EM, Dawicki W, Duncan GS, Bukczynski J, Plyte S, Elia A, Wakeham A, Itie A, Chung S, Da Costa J, Arya S, Horan T, Campbell P, Gaida K, Ohashi PS, Watts TH, Yoshinaga SK, Bray MR, Jordana M, Mak TW
Nat Immunol. 2003
PubMed ID: 12925852
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Rapid recovery from T lymphopenia by CD28 superagonist therapy.
Elflein K, Rodriguez-Palmero M, Kerkau T, Hünig T
Blood. 2003
PubMed ID: 12750179
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T cell costimulatory molecule function determines susceptibility to infection with Pneumocystis carinii in mice.
Beck JM, Blackmon MB, Rose CM, Kimzey SL, Preston AM, Green JM
J Immunol. 2003
PubMed ID: 12902500
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Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23.
Fourie AM, Coles F, Moreno V, Karlsson L
J Biol Chem. 2003
PubMed ID: 12777399
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Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways.
Butler JJ, Mader JS, Watson CL, Zhang H, Blay J, Hoskin DW
J Cell Biochem. 2003
PubMed ID: 12874832
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Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation.
Egawa T, Albrecht B, Favier B, Sunshine MJ, Mirchandani K, O'Brien W, Thome M, Littman DR
Curr Biol. 2003
PubMed ID: 12867038
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Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo.
Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, Mohrs M, Locksley RM, Kronenberg M
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12829795
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Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4.
Sugita S, Streilein JW
J Exp Med. 2003
PubMed ID: 12835481
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CTLA-4 and CD28 gene polymorphisms in susceptibility, clinical course and progression of multiple sclerosis.
van Veen T, Crusius JB, van Winsen L, Xia B, Barkhof F, Salvador Peña A, Polman CH, Uitdehaag BM
J Neuroimmunol. 2003
PubMed ID: 12864988
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Treatment and prevention of experimental autoimmune neuritis with superagonistic CD28-specific monoclonal antibodies.
Schmidt J, Elflein K, Stienekemeier M, Rodriguez-Palmero M, Schneider C, Toyka KV, Gold R, Hünig T
J Neuroimmunol. 2003
PubMed ID: 12864982
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Resistance of CD28-deficient mice to autologous phase of anti-glomerular basement membrane glomerulonephritis.
Nitta K, Horita S, Ogawa S, Matsumoto M, Hara Y, Okano K, Hayashi T, Abe R, Nihei H
Clin Exp Nephrol. 2003
PubMed ID: 14586728
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A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
Buhlmann JE, Elkin SK, Sharpe AH
J Immunol. 2003
PubMed ID: 12759417
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Immunity in the absence of CD28 and CD137 (4-1BB) molecules.
Vinay DS, Wolisi GO, Yu KY, Choi BK, Kwon BS
Immunol Cell Biol. 2003
PubMed ID: 12752681
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CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation.
Warrington KJ, Vallejo AN, Weyand CM, Goronzy JJ
Blood. 2003
PubMed ID: 12506015
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Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists.
Lühder F, Huang Y, Dennehy KM, Guntermann C, Müller I, Winkler E, Kerkau T, Ikemizu S, Davis SJ, Hanke T, Hünig T
J Exp Med. 2003
PubMed ID: 12707299
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HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.
Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M
J Biosci. 2003
PubMed ID: 12734410
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The role of PI3K in immune cells.
Koyasu S
Nat Immunol. 2003
PubMed ID: 12660731
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CD28 signal enhances apoptosis of CD8 T cells after strong TCR ligation.
Yu XZ, Martin PJ, Anasetti C
J Immunol. 2003
PubMed ID: 12626553
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Vav-1 and the IKK alpha subunit of I kappa B kinase functionally associate to induce NF-kappa B activation in response to CD28 engagement.
Piccolella E, Spadaro F, Ramoni C, Marinari B, Costanzo A, Levrero M, Thomson L, Abraham RT, Tuosto L
J Immunol. 2003
PubMed ID: 12626540
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Sex-specific quantitative trait loci govern susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination.
Butterfield RJ, Roper RJ, Rhein DM, Melvold RW, Haynes L, Ma RZ, Doerge RW, Teuscher C
Genetics. 2003
PubMed ID: 12663542
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A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production.
Matsumoto A, Seki Y, Watanabe R, Hayashi K, Johnston JA, Harada Y, Abe R, Yoshimura A, Kubo M
J Exp Med. 2003
PubMed ID: 12591901
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Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection.
Shedlock DJ, Whitmire JK, Tan J, MacDonald AS, Ahmed R, Shen H
J Immunol. 2003
PubMed ID: 12574376
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CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism.
Chung DR, Kasper DL, Panzo RJ, Chitnis T, Grusby MJ, Sayegh MH, Tzianabos AO, Chtinis T
J Immunol. 2003
PubMed ID: 12574364
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CD28 costimulation is critical for experimental allergic asthma in HLA-DQ8 transgenic mice.
Chapoval SP, David CS
Clin Immunol. 2003
PubMed ID: 12672399
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CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo.
Tang Q, Smith JA, Szot GL, Zhou P, Alegre ML, Henriksen KJ, Thompson CB, Bluestone JA
J Immunol. 2003
PubMed ID: 12538715
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A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS).
Harada Y, Ohgai D, Watanabe R, Okano K, Koiwai O, Tanabe K, Toma H, Altman A, Abe R
J Exp Med. 2003
PubMed ID: 12538664
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CD28 costimulation is required for in vivo induction of peripheral tolerance in CD8 T cells.
Vacchio MS, Hodes RJ
J Exp Med. 2003
PubMed ID: 12515810
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FasL-induced downregulation of CD28 expression on jurkat cells in vitro is associated with activation of caspases.
Ma S, Ochi H, Cui L, He W
Cell Biol Int. 2003
PubMed ID: 14642527
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[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]
Bénichou S, Benmerah A
Med Sci (Paris). 2003
PubMed ID: 12836198
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Anti-CD28 has a potent adjuvant effect on the antibody response to soluble antigens mediated through CTLA-4 by-pass.
Carlring J, Barr TA, Buckle AM, Heath AW
Eur J Immunol. 2003
PubMed ID: 12594842
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Short cytoplasmic SDYMNM segment of CD28 is sufficient to convert CTLA-4 to a positive signaling receptor.
Yin L, Schneider H, Rudd CE
J Leukoc Biol. 2003
PubMed ID: 12525576
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Strong differential regulation of serum and mucosal IgA responses as revealed in CD28-deficient mice using cholera toxin adjuvant.
Gärdby E, Wrammert J, Schön K, Ekman L, Leanderson T, Lycke N
J Immunol. 2003
PubMed ID: 12496383
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Differential chemokine expression profiles in human peripheral blood T lymphocytes: dependence on T-cell coreceptor and calcineurin signaling.
Cristillo AD, Macri MJ, Bierer BE
Blood. 2003
PubMed ID: 12393716
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Cutting edge: B7/CD28 interactions regulate cell cycle progression independent of the strength of TCR signaling.
Bonnevier JL, Mueller DL
J Immunol. 2002
PubMed ID: 12471093
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Molecular basis for the loss of CD28 expression in senescent T cells.
Vallejo AN, Bryl E, Klarskov K, Naylor S, Weyand CM, Goronzy JJ
J Biol Chem. 2002
PubMed ID: 12324461
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans.
Montagnoli C, Bacci A, Bozza S, Gaziano R, Mosci P, Sharpe AH, Romani L
J Immunol. 2002
PubMed ID: 12444136
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Role of ICOS versus CD28 in antiviral immunity.
Bertram EM, Tafuri A, Shahinian A, Chan VS, Hunziker L, Recher M, Ohashi PS, Mak TW, Watts TH
Eur J Immunol. 2002
PubMed ID: 12432568
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Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus.
Valenzuela HF, Effros RB
Clin Immunol. 2002
PubMed ID: 12482386
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CD28, TNF receptor, and IL-12 are critical for CD4-independent cross-priming of therapeutic antitumor CD8+ T cells.
Hu HM, Winter H, Ma J, Croft M, Urba WJ, Fox BA
J Immunol. 2002
PubMed ID: 12391201
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Chimeric co-stimulatory molecules that selectively act through CD28 or CTLA-4 on human T cells.
Lazetic S, Leong SR, Chang JC, Ong R, Dawes G, Punnonen J
J Biol Chem. 2002
PubMed ID: 12167647
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Human eosinophils express and release IL-13 following CD28-dependent activation.
Woerly G, Lacy P, Younes AB, Roger N, Loiseau S, Moqbel R, Capron M
J Leukoc Biol. 2002
PubMed ID: 12377947
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Mice deficient in perforin, CD4+ T cells, or CD28-mediated signaling maintain the typical immunodominance hierarchies of CD8+ T-cell responses to influenza virus.
Chen W, Bennink JR, Morton PA, Yewdell JW
J Virol. 2002
PubMed ID: 12239309
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CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis.
Mencacci A, Montagnoli C, Bacci A, Cenci E, Pitzurra L, Spreca A, Kopf M, Sharpe AH, Romani L
J Immunol. 2002
PubMed ID: 12218136
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Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors.
Riley JL, Mao M, Kobayashi S, Biery M, Burchard J, Cavet G, Gregson BP, June CH, Linsley PS
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12195015
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Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation.
Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12195013
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ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells.
Witsch EJ, Peiser M, Hutloff A, Büchner K, Dorner BG, Jonuleit H, Mages HW, Kroczek RA
Eur J Immunol. 2002
PubMed ID: 12207353
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The Th2-response in mercuric chloride-induced autoimmunity requires continuing costimulation via CD28.
Macphee IA, Turner DR, Yagita H, Oliveira DB
Clin Exp Immunol. 2002
PubMed ID: 12197880
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Expression of CD28 by bone marrow stromal cells and its involvement in B lymphopoiesis.
Gray Parkin K, Stephan RP, Apilado RG, Lill-Elghanian DA, Lee KP, Saha B, Witte PL
J Immunol. 2002
PubMed ID: 12193694
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Cutting edge: regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination.
Zhang J, Bárdos T, Li D, Gál I, Vermes C, Xu J, Mikecz K, Finnegan A, Lipkowitz S, Glant TT
J Immunol. 2002
PubMed ID: 12193687
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MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses.
VanLith ML, Kohlgraf KG, Sivinski CL, Tempero RM, Hollingsworth MA
Int Immunol. 2002
PubMed ID: 12147624
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A role for inducible costimulator protein in the CD28- independent mechanism of resistance to Toxoplasma gondii.
Villegas EN, Lieberman LA, Mason N, Blass SL, Zediak VP, Peach R, Horan T, Yoshinaga S, Hunter CA
J Immunol. 2002
PubMed ID: 12097399
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Human neutrophil-expressed CD28 interacts with macrophage B7 to induce phosphatidylinositol 3-kinase-dependent IFN-gamma secretion and restriction of Leishmania growth.
Venuprasad K, Banerjee PP, Chattopadhyay S, Sharma S, Pal S, Parab PB, Mitra D, Saha B
J Immunol. 2002
PubMed ID: 12097397
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CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse.
Huang J, Lo PF, Zal T, Gascoigne NR, Smith BA, Levin SD, Grey HM
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12077322
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APC-dependent impairment of T cell proliferation in aging: role of CD28- and IL-12/IL-15-mediated signaling.
Tortorella C, Pisconti A, Piazzolla G, Antonaci S
Mech Ageing Dev. 2002
PubMed ID: 12297341
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Therapeutic effects of tumor reactive CD4+ cells generated from tumor-primed lymph nodes using anti-CD3/anti-CD28 monoclonal antibodies.
Li Q, Yu B, Grover AC, Zeng X, Chang AE
J Immunother. 2002
PubMed ID: 12142553
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Role of CD28 co-stimulation in generation and maintenance of virus-specific T cells.
Christensen JE, Christensen JP, Kristensen NN, Hansen NJ, Stryhn A, Thomsen AR
Int Immunol. 2002
PubMed ID: 12096029
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Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.
Cook JA, August A, Henderson AJ
J Immunol. 2002
PubMed ID: 12077252
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Expansion of a CD28-intermediate subset among CD8 T cells in patients with infectious mononucleosis.
Uda H, Mima T, Yamaguchi N, Katada Y, Fukuda M, Fujii N, Nakamura K, Saiki O
J Virol. 2002
PubMed ID: 12050373
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Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis.
Scheu S, Alferink J, Pötzel T, Barchet W, Kalinke U, Pfeffer K
J Exp Med. 2002
PubMed ID: 12070288
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Memory Th2 effector cells can develop in the absence of B7-1/B7-2, CD28 interactions, and effector Th cells after priming with an intestinal nematode parasite.
Ekkens MJ, Liu Z, Liu Q, Foster A, Whitmire J, Pesce J, Sharpe AH, Urban JF, Gause WC
J Immunol. 2002
PubMed ID: 12055251
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Effect of rapamycin on the cyclosporin A-resistant CD28-mediated costimulatory pathway.
Ghosh P, Buchholz MA, Yano S, Taub D, Longo DL
Blood. 2002
PubMed ID: 12036883
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The CD28 signaling pathway regulates glucose metabolism.
Frauwirth KA, Riley JL, Harris MH, Parry RV, Rathmell JC, Plas DR, Elstrom RL, June CH, Thompson CB
Immunity. 2002
PubMed ID: 12121659
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Impaired germinal centre formation and humoral immune response in the absence of CD28 and interleukin-4.
Reiter R, Pfeffer K
Immunology. 2002
PubMed ID: 12047751
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A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD
Science. 2002
PubMed ID: 12040188
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The regulation of protein synthesis and translation factors by CD3 and CD28 in human primary T lymphocytes.
Kleijn M, Proud CG
BMC Biochem. 2002
PubMed ID: 12028592
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Mutational analysis of CD28 in coeliac disease.
Popat S, Hearle N, Bevan S, Hogberg L, Stenhammar L, Houlston RS
Scand J Gastroenterol. 2002
PubMed ID: 12059054
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Activated T lymphocytes disappear from circulation during endotoxemia in humans.
Krabbe KS, Bruunsgaard H, Qvist J, Fonsmark L, Møller K, Hansen CM, Skinhøj P, Pedersen BK
Clin Diagn Lab Immunol. 2002
PubMed ID: 11986289
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CD28 costimulation induces delta opioid receptor expression during anti-CD3 activation of T cells.
Nguyen K, Miller BC
J Immunol. 2002
PubMed ID: 11970987
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Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11.
Hsu HC, Mountz JD, Williams RW, Shelton BJ, Yang PA, Matsuki Y, Xu X, Dodd CH, Li L, Geiger H, Zhang HG, Van Zant G
Mech Ageing Dev. 2002
PubMed ID: 12044964
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Antibody-mediated control of persistent gamma-herpesvirus infection.
Kim IJ, Flaño E, Woodland DL, Blackman MA
J Immunol. 2002
PubMed ID: 11937552
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Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation.
Zhou XY, Yashiro-Ohtani Y, Nakahira M, Park WR, Abe R, Hamaoka T, Naramura M, Gu H, Fujiwara H
J Immunol. 2002
PubMed ID: 11937538
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Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection.
Bertram EM, Lau P, Watts TH
J Immunol. 2002
PubMed ID: 11937529
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B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo.
Bai XF, Liu J, May KF, Guo Y, Zheng P, Liu Y
Blood. 2002
PubMed ID: 11929778
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The phosphatidylinositol phosphatase PTEN is under control of costimulation and regulates proliferation in human T cells.
Schmidt-Weber CB, Wohlfahrt JG, Akdis CA, Blaser K
Eur J Immunol. 2002
PubMed ID: 11932928
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CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes.
Williams JA, Sharrow SO, Adams AJ, Hodes RJ
J Immunol. 2002
PubMed ID: 11884443
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CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells.
Appleman LJ, van Puijenbroek AA, Shu KM, Nadler LM, Boussiotis VA
J Immunol. 2002
PubMed ID: 11884439
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Differential effect of CD28 versus B7 blockade on direct pathway of allorecognition and self-restricted responses.
Haspot F, Villemain F, Laflamme G, Coulon F, Olive D, Tiollier J, Soulillou JP, Vanhove B
Blood. 2002
PubMed ID: 11877302
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A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28.
Hanawa H, Ma Y, Mikolajczak SA, Charles ML, Yoshida T, Yoshida R, Strathdee CA, Litchfield DW, Ochi A
Blood. 2002
PubMed ID: 11877290
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CD40/CD40L interaction is essential for the induction of EAE in the absence of CD28-mediated co-stimulation.
Girvin AM, Dal Canto MC, Miller SD
J Autoimmun. 2002
PubMed ID: 11908941
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CD28(-/-) mice show defects in cellular and humoral immunity but are able to control infection with murine gammaherpesvirus 68.
Lee BJ, Reiter SK, Anderson M, Sarawar SR
J Virol. 2002
PubMed ID: 11861872
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Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses.
Tzachanis D, Berezovskaya A, Nadler LM, Boussiotis VA
Blood. 2002
PubMed ID: 11830501
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CD28 costimulation and parasite dose combine to influence the susceptibility of BALB/c mice to infection with Leishmania major.
Compton HL, Farrell JP
J Immunol. 2002
PubMed ID: 11801669
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CD25+ immunoregulatory T-cells of donor origin suppress alloreactivity after BMT.
Johnson BD, Konkol MC, Truitt RL
Biol Blood Marrow Transplant. 2002
PubMed ID: 12434947
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CD28 function: a balance of costimulatory and regulatory signals.
Bour-Jordan H, Blueston JA
J Clin Immunol. 2002
PubMed ID: 11958588
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A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytes.
Deshpande M, Venuprasad K, Parab PB, Saha B, Mitra D
Hum Immunol. 2002
PubMed ID: 11916166
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Interleukin-2-deficient mice develop colitis in the absence of CD28 costimulation.
Boone DL, Dassopoulos T, Lodolce JP, Chai S, Chien M, Ma A
Inflamm Bowel Dis. 2002
PubMed ID: 11837936
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CTLA-4/CD28 gene region is associated with genetic susceptibility to coeliac disease in UK families.
King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM, Ellis HJ, Ciclitira PJ
J Med Genet. 2002
PubMed ID: 11826026
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Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches.
Ling V, Wu PW, Finnerty HF, Agostino MJ, Graham JR, Chen S, Jussiff JM, Fisk GJ, Miller CP, Collins M
Genomics. 2001
PubMed ID: 11735222
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Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule.
Hombach A, Wieczarkowiecz A, Marquardt T, Heuser C, Usai L, Pohl C, Seliger B, Abken H
J Immunol. 2001
PubMed ID: 11714771
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The immunological synapse and CD28-CD80 interactions.
Bromley SK, Iaboni A, Davis SJ, Whitty A, Green JM, Shaw AS, Weiss A, Dustin ML
Nat Immunol. 2001
PubMed ID: 11713465
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A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice.
Farmer MA, Sundberg JP, Bristol IJ, Churchill GA, Li R, Elson CO, Leiter EH
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11707574
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The development of a Th1-type response and resistance to Leishmania major infection in the absence of CD40-CD40L costimulation.
Padigel UM, Perrin PJ, Farrell JP
J Immunol. 2001
PubMed ID: 11698463
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Homeostatic expansion occurs independently of costimulatory signals.
Prlic M, Blazar BR, Khoruts A, Zell T, Jameson SC
J Immunol. 2001
PubMed ID: 11698438
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Role of CD28 for the generation and expansion of antigen-specific CD8(+) T lymphocytes during infection with Listeria monocytogenes.
Mittrücker HW, Kursar M, Köhler A, Hurwitz R, Kaufmann SH
J Immunol. 2001
PubMed ID: 11698433
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Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory.
Suresh M, Whitmire JK, Harrington LE, Larsen CP, Pearson TC, Altman JD, Ahmed R
J Immunol. 2001
PubMed ID: 11698427
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Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure.
Burne MJ, Daniels F, El Ghandour A, Mauiyyedi S, Colvin RB, O'Donnell MP, Rabb H
J Clin Invest. 2001
PubMed ID: 11696572
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CD28 is not required for c-Jun N-terminal kinase activation in T cells.
Rivas FV, O'Herrin S, Gajewski TF
J Immunol. 2001
PubMed ID: 11544297
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OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells.
Rogers PR, Song J, Gramaglia I, Killeen N, Croft M
Immunity. 2001
PubMed ID: 11567634
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Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.
Fang D, Liu YC
Nat Immunol. 2001
PubMed ID: 11526404
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Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis.
Ndhlovu LC, Ishii N, Murata K, Sato T, Sugamura K
J Immunol. 2001
PubMed ID: 11509650
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Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice.
Okazaki T, Nakao A, Nakano H, Takahashi F, Takahashi K, Shimozato O, Takeda K, Yagita H, Okumura K
J Immunol. 2001
PubMed ID: 11489978
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CD28 co-stimulates TCR/CD3-induced phosphoinositide turnover in human T lymphocytes.
Zaru R, Berrie CP, Iurisci C, Corda D, Valitutti S
Eur J Immunol. 2001
PubMed ID: 11500828
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The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.
Kirchgessner H, Dietrich J, Scherer J, Isomäki P, Korinek V, Hilgert I, Bruyns E, Leo A, Cope AP, Schraven B
J Exp Med. 2001
PubMed ID: 11390434
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Requirement for a complex array of costimulators in the negative selection of autoreactive thymocytes in vivo.
Li R, Page DM
J Immunol. 2001
PubMed ID: 11342622
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Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways.
Hayakawa Y, Takeda K, Yagita H, Van Kaer L, Saiki I, Okumura K
J Immunol. 2001
PubMed ID: 11342617
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CD28 and CTLA4 coordinately regulate airway inflammatory cell recruitment and T-helper cell differentiation after inhaled allergen.
Burr JS, Kimzey SL, Randolph DR, Green JM
Am J Respir Cell Mol Biol. 2001
PubMed ID: 11350825
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Inhibition of natural killer cells results in acceptance of cardiac allografts in CD28-/- mice.
Maier S, Tertilt C, Chambron N, Gerauer K, Hüser N, Heidecke CD, Pfeffer K
Nat Med. 2001
PubMed ID: 11329056
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Mechanism for down-regulation of CD28 by Nef.
Swigut T, Shohdy N, Skowronski J
EMBO J. 2001
PubMed ID: 11285224
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B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.
Mandelbrot DA, Oosterwegel MA, Shimizu K, Yamada A, Freeman GJ, Mitchell RN, Sayegh MH, Sharpe AH
J Clin Invest. 2001
PubMed ID: 11285307
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A point mutation in CD28 distinguishes proliferative signals from survival signals.
Okkenhaug K, Wu L, Garza KM, La Rose J, Khoo W, Odermatt B, Mak TW, Ohashi PS, Rottapel R
Nat Immunol. 2001
PubMed ID: 11276203
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Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo.
Harada Y, Tokushima M, Matsumoto Y, Ogawa S, Otsuka M, Hayashi K, Weiss BD, June CH, Abe R
J Immunol. 2001
PubMed ID: 11238622
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CD28-independent induction of experimental autoimmune encephalomyelitis.
Chitnis T, Najafian N, Abdallah KA, Dong V, Yagita H, Sayegh MH, Khoury SJ
J Clin Invest. 2001
PubMed ID: 11238558
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Acquisition of CD80 (B7-1) by T cells.
Sabzevari H, Kantor J, Jaigirdar A, Tagaya Y, Naramura M, Hodge J, Bernon J, Schlom J
J Immunol. 2001
PubMed ID: 11160311
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice.
Heinly CS, Sempowski GD, Lee DM, Patel DD, McDermott PM, Scearce RM, Thompson CB, Haynes BF
Int Immunol. 2001
PubMed ID: 11157849
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B7/CD28 costimulation is critical in susceptibility to Pseudomonas aeruginosa corneal infection: a comparative study using monoclonal antibody blockade and CD28-deficient mice.
Hazlett LD, McClellan S, Barrett R, Rudner X
J Immunol. 2001
PubMed ID: 11145712
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CD28 stimulation regulates its association with N-ethylmaleimide-sensitive fusion protein and other proteins involved in vesicle sorting.
Heller M, Watts JD, Aebersold R
Proteomics. 2001
PubMed ID: 11680900
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Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6.
Marti F, Krause A, Post NH, Lyddane C, Dupont B, Sadelain M, King PD
J Immunol. 2001
PubMed ID: 11123293
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Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis.
Ishikawa T, Tamai Y, Zorn AM, Yoshida H, Seldin MF, Nishikawa S, Taketo MM
Development. 2001
PubMed ID: 11092808
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CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplants.
Fischbein MP, Ardehali A, Yun J, Schoenberger S, Laks H, Irie Y, Dempsey P, Cheng G, Fishbein MC, Bonavida B
J Immunol. 2000
PubMed ID: 11120867
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B7 requirements for primary and secondary protein- and polysaccharide-specific Ig isotype responses to Streptococcus pneumoniae.
Wu ZQ, Khan AQ, Shen Y, Schartman J, Peach R, Lees A, Mond JJ, Gause WC, Snapper CM
J Immunol. 2000
PubMed ID: 11120807
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Role of TNF receptor-associated factor 2 and p38 mitogen-activated protein kinase activation during 4-1BB-dependent immune response.
Cannons JL, Choi Y, Watts TH
J Immunol. 2000
PubMed ID: 11086053
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
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Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions.
Blazar BR, Lees CJ, Martin PJ, Noelle RJ, Kwon B, Murphy W, Taylor PA
J Immunol. 2000
PubMed ID: 11046015
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Structure of murine CTLA-4 and its role in modulating T cell responsiveness.
Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG
Science. 2000
PubMed ID: 11052947
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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Soluble CD86 is a costimulatory molecule for human T lymphocytes.
Jeannin P, Magistrelli G, Aubry JP, Caron G, Gauchat JF, Renno T, Herbault N, Goetsch L, Blaecke A, Dietrich PY, Bonnefoy JY, Delneste Y
Immunity. 2000
PubMed ID: 11021528
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Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation.
Lambrecht BN, De Veerman M, Coyle AJ, Gutierrez-Ramos JC, Thielemans K, Pauwels RA
J Clin Invest. 2000
PubMed ID: 10953030
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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.
Takahashi T, Tagami T, Yamazaki S, Uede T, Shimizu J, Sakaguchi N, Mak TW, Sakaguchi S
J Exp Med. 2000
PubMed ID: 10899917
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Latent murine gamma-herpesvirus infection is established in activated B cells, dendritic cells, and macrophages.
Flaño E, Husain SM, Sample JT, Woodland DL, Blackman MA
J Immunol. 2000
PubMed ID: 10878386
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Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection.
Kopf M, Coyle AJ, Schmitz N, Barner M, Oxenius A, Gallimore A, Gutierrez-Ramos JC, Bachmann MF
J Exp Med. 2000
PubMed ID: 10880526
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The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo.
Kishimoto K, Dong VM, Issazadeh S, Fedoseyeva EV, Waaga AM, Yamada A, Sho M, Benichou G, Auchincloss H, Grusby MJ, Khoury SJ, Sayegh MH
J Clin Invest. 2000
PubMed ID: 10880049
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GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28.
Ellis JH, Ashman C, Burden MN, Kilpatrick KE, Morse MA, Hamblin PA
J Immunol. 2000
PubMed ID: 10820259
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The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis.
Bai XF, Liu JQ, Liu X, Guo Y, Cox K, Wen J, Zheng P, Liu Y
J Clin Invest. 2000
PubMed ID: 10791997
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The roles of CD28 and CD40 ligand in T cell activation and tolerance.
Howland KC, Ausubel LJ, London CA, Abbas AK
J Immunol. 2000
PubMed ID: 10779746
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Engagement of CD28 modulates CXC chemokine receptor 4 surface expression in both resting and CD3-stimulated CD4+ T cells.
Secchiero P, Zella D, Curreli S, Mirandola P, Capitani S, Gallo RC, Zauli G
J Immunol. 2000
PubMed ID: 10754293
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T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells.
Hwang I, Huang JF, Kishimoto H, Brunmark A, Peterson PA, Jackson MR, Surh CD, Cai Z, Sprent J
J Exp Med. 2000
PubMed ID: 10748232
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The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease.
Liu P, Aitken K, Kong YY, Opavsky MA, Martino T, Dawood F, Wen WH, Kozieradzki I, Bachmaier K, Straus D, Mak TW, Penninger JM
Nat Med. 2000
PubMed ID: 10742150
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Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses.
Andreasen SO, Christensen JE, Marker O, Thomsen AR
J Immunol. 2000
PubMed ID: 10725727
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Coordinate regulation of T cell activation by CD2 and CD28.
Green JM, Karpitskiy V, Kimzey SL, Shaw AS
J Immunol. 2000
PubMed ID: 10725714
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The role of B7 costimulation in CD4/CD8 T cell homeostasis.
Yu X, Fournier S, Allison JP, Sharpe AH, Hodes RJ
J Immunol. 2000
PubMed ID: 10725709
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Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice.
Haywood ME, Hogarth MB, Slingsby JH, Rose SJ, Allen PJ, Thompson EM, Maibaum MA, Chandler P, Davies KA, Simpson E, Walport MJ, Morley BJ
Arthritis Rheum. 2000
PubMed ID: 10693874
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The Nef protein of HIV-1 associates with rafts and primes T cells for activation.
Wang JK, Kiyokawa E, Verdin E, Trono D
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10618429
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Immune modulation in pemphigus vulgaris: role of CD28 and IL-10.
Toto P, Feliciani C, Amerio P, Suzuki H, Wang B, Shivji GM, Woodley D, Sauder DN
J Immunol. 2000
PubMed ID: 10605050
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Critical role of CD28 in protective immunity against Salmonella typhimurium.
Mittrücker HW, Köhler A, Mak TW, Kaufmann SH
J Immunol. 1999
PubMed ID: 10586076
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Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes.
Perez-Villar JJ, Kanner SB
J Immunol. 1999
PubMed ID: 10586033
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Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus.
DeBenedette MA, Wen T, Bachmann MF, Ohashi PS, Barber BH, Stocking KL, Peschon JJ, Watts TH
J Immunol. 1999
PubMed ID: 10528184
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Ligation of CD28 in vivo induces CD40 ligand expression and promotes B cell survival.
Yin D, Zhang L, Wang R, Radvanyi L, Haudenschild C, Fang Q, Kehry MR, Shi Y
J Immunol. 1999
PubMed ID: 10510372
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CD28 interactions with either CD80 or CD86 are sufficient to induce allergic airway inflammation in mice.
Mathur M, Herrmann K, Qin Y, Gulmen F, Li X, Krimins R, Weinstock J, Elliott D, Bluestone JA, Padrid P
Am J Respir Cell Mol Biol. 1999
PubMed ID: 10502560
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The CD28/B7 interaction is not required for resistance to Toxoplasma gondii in the brain but contributes to the development of immunopathology.
Reichmann G, Villegas EN, Craig L, Peach R, Hunter CA
J Immunol. 1999
PubMed ID: 10477605
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Role of CD28 in the generation of effector and memory responses required for resistance to Toxoplasma gondii.
Villegas EN, Elloso MM, Reichmann G, Peach R, Hunter CA
J Immunol. 1999
PubMed ID: 10477604
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Role of the costimulatory molecule CD28 in the development of lupus in MRL/lpr mice.
Tada Y, Nagasawa K, Ho A, Morito F, Koarada S, Ushiyama O, Suzuki N, Ohta A, Mak TW
J Immunol. 1999
PubMed ID: 10477582
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Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis.
Chang TT, Jabs C, Sobel RA, Kuchroo VK, Sharpe AH
J Exp Med. 1999
PubMed ID: 10477557
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Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation.
Holdorf AD, Green JM, Levin SD, Denny MF, Straus DB, Link V, Changelian PS, Allen PM, Shaw AS
J Exp Med. 1999
PubMed ID: 10430626
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CD28, IL-2-independent costimulatory pathways for CD8 T lymphocyte activation.
Sepulveda H, Cerwenka A, Morgan T, Dutton RW
J Immunol. 1999
PubMed ID: 10415007
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Several different cell surface molecules control negative selection of medullary thymocytes.
Kishimoto H, Sprent J
J Exp Med. 1999
PubMed ID: 10429671
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Triggering of murine NK cells by CD40 and CD86 (B7-2).
Martín-Fontecha A, Assarsson E, Carbone E, Kärre K, Ljunggren HG
J Immunol. 1999
PubMed ID: 10229827
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CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis.
Oliveira-dos-Santos AJ, Ho A, Tada Y, Lafaille JJ, Tonegawa S, Mak TW, Penninger JM
J Immunol. 1999
PubMed ID: 10201986
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Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts.
Nakatsuji T
Tohoku J Exp Med. 1999
PubMed ID: 10458478
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Timing and casting for actors of thymic negative selection.
Dautigny N, Le Campion A, Lucas B
J Immunol. 1999
PubMed ID: 9973382
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On costimulatory signals and T cell tolerance: relevance for transplantation immunity.
Holländer GA, Zuklys S, Förster E, Krenger W
Transplant Proc. 1999
PubMed ID: 10078224
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CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28.
Slavik JM, Hutchcroft JE, Bierer BE
J Biol Chem. 1999
PubMed ID: 9915850
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CD28-deficient mice are highly resistant to collagen-induced arthritis.
Tada Y, Nagasawa K, Ho A, Morito F, Ushiyama O, Suzuki N, Ohta H, Mak TW
J Immunol. 1999
PubMed ID: 9886387
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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Expression and function of CTLA-4 in Th1 and Th2 cells.
Alegre ML, Shiels H, Thompson CB, Gajewski TF
J Immunol. 1998
PubMed ID: 9759851
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Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction.
Okkenhaug K, Rottapel R
J Biol Chem. 1998
PubMed ID: 9694876
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Impaired negative selection in CD28-deficient mice.
Noel PJ, Alegre ML, Reiner SL, Thompson CB
Cell Immunol. 1998
PubMed ID: 9732701
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B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.
Fallarino F, Fields PE, Gajewski TF
J Exp Med. 1998
PubMed ID: 9653097
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Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.
Lin H, Rathmell JC, Gray GS, Thompson CB, Leiden JM, Alegre ML
J Exp Med. 1998
PubMed ID: 9653096
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Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice.
Gärdby E, Lane P, Lycke NY
J Immunol. 1998
PubMed ID: 9647206
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CD28-independent induction of T helper cells and immunoglobulin class switches requires costimulation by the heat-stable antigen.
Wu Y, Zhou Q, Zheng P, Liu Y
J Exp Med. 1998
PubMed ID: 9529332
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Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-kappaB factors.
Ott M, Lovett JL, Mueller L, Verdin E
J Immunol. 1998
PubMed ID: 9510190
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Ceramide-independent CD28 and TCR signaling but reduced IL-2 secretion in T cells of acid sphingomyelinase-deficient mice.
Stoffel B, Bauer P, Nix M, Deres K, Stoffel W
Eur J Immunol. 1998
PubMed ID: 9541582
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IL-4 enhances long-term survival of CD28-deficient T cells.
Stack RM, Thompson CB, Fitch FW
J Immunol. 1998
PubMed ID: 9498765
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CD28/B7 costimulation: a review.
Greenfield EA, Nguyen KA, Kuchroo VK
Crit Rev Immunol. 1998
PubMed ID: 9784967
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Interleukin-12-activated natural killer cells recognize B7 costimulatory molecules on tumor cells and autologous dendritic cells.
Geldhof AB, Moser M, Lespagnard L, Thielemans K, De Baetselier P
Blood. 1998
PubMed ID: 9414285
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Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation.
Herold KC, Lu J, Rulifson I, Vezys V, Taub D, Grusby MJ, Bluestone JA
J Immunol. 1997
PubMed ID: 9379007
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Homotypic interaction of the heat-stable antigen is not responsible for its co-stimulatory activity for T cell clonal expansion.
Zhou Q, Wu Y, Nielsen PJ, Liu Y
Eur J Immunol. 1997
PubMed ID: 9368605
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Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways.
Daikh DI, Finck BK, Linsley PS, Hollenbaugh D, Wofsy D
J Immunol. 1997
PubMed ID: 9317105
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Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.
Nishina H, Bachmann M, Oliveira-dos-Santos AJ, Kozieradzki I, Fischer KD, Odermatt B, Wakeham A, Shahinian A, Takimoto H, Bernstein A, Mak TW, Woodgett JR, Ohashi PS, Penninger JM
J Exp Med. 1997
PubMed ID: 9294148
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CD28 costimulation and T lymphocyte proliferative responses in HIV-1 infection.
Carlesimo M, Pontesilli O, Varani AR, Bernardi ML, Mazzone AM, Rosso R, Guerra EC, Cassone A, Paganelli R, Aiuti F
Clin Exp Immunol. 1997
PubMed ID: 9328113
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CD28 is not required for rejection of unmanipulated syngeneic and autologous tumors.
Wen T, Kono K, Shahinian A, Kiessling R, Mak TW, Klein G
Eur J Immunol. 1997
PubMed ID: 9295036
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Synergy between CD28 and CD9 costimulation for naive T-cell activation.
Toyo-oka K, Tai XG, Yashiro Y, Ahn HJ, Abe R, Hamaoka T, Kobayashi M, Neben S, Fujiwara H
Immunol Lett. 1997
PubMed ID: 9436464
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A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development.
Wiest DL, Ashe JM, Howcroft TK, Lee HM, Kemper DM, Negishi I, Singer DS, Singer A, Abe R
Immunity. 1997
PubMed ID: 9208839
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Murine lymphotactin: gene structure, post-translational modification and inhibition of expression by CD28 costimulation.
Hautamaa D, Merica R, Chen Z, Jenkins MK
Cytokine. 1997
PubMed ID: 9199871
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CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo.
Vella AT, Mitchell T, Groth B, Linsley PS, Green JM, Thompson CB, Kappler JW, Marrack P
J Immunol. 1997
PubMed ID: 9144484
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CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response.
Gause WC, Chen SJ, Greenwald RJ, Halvorson MJ, Lu P, Zhou XD, Morris SC, Lee KP, June CH, Finkelman FD, Urban JF, Abe R
J Immunol. 1997
PubMed ID: 9126966
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Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway.
Ott M, Emiliani S, Van Lint C, Herbein G, Lovett J, Chirmule N, McCloskey T, Pahwa S, Verdin E
Science. 1997
PubMed ID: 9045614
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T cell-mediated elimination of B7.2 transgenic B cells.
Fournier S, Rathmell JC, Goodnow CC, Allison JP
Immunity. 1997
PubMed ID: 9075933
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Lck regulates Vav activation of members of the Rho family of GTPases.
Han J, Das B, Wei W, Van Aelst L, Mosteller RD, Khosravi-Far R, Westwick JK, Der CJ, Broek D
Mol Cell Biol. 1997
PubMed ID: 9032261
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CD28 costimulation promotes the production of Th2 cytokines.
Rulifson IC, Sperling AI, Fields PE, Fitch FW, Bluestone JA
J Immunol. 1997
PubMed ID: 8992981
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Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK.
King PD, Sadra A, Teng JM, Xiao-Rong L, Han A, Selvakumar A, August A, Dupont B
J Immunol. 1997
PubMed ID: 8992971
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Contribution of the CD28 molecule to allergic and irritant-induced skin reactions in CD28 -/- mice.
Kondo S, Kooshesh F, Wang B, Fujisawa H, Sauder DN
J Immunol. 1996
PubMed ID: 8943384
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High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters.
Himes SR, Coles LS, Reeves R, Shannon MF
Immunity. 1996
PubMed ID: 8934574
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CD28-deficient mice generate an impaired Th2 response to Schistosoma mansoni infection.
King CL, Xianli J, June CH, Abe R, Lee KP
Eur J Immunol. 1996
PubMed ID: 8898959
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Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.
Boussiotis VA, Barber DL, Lee BJ, Gribben JG, Freeman GJ, Nadler LM
J Exp Med. 1996
PubMed ID: 8760790
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Reversal of the inhibitory effects of HIV-gp120 on CD4+ T cells by stimulation through the CD28 pathway.
Faith A, Yssel H, O'Hehir RE, Lamb JR
Clin Exp Immunol. 1996
PubMed ID: 8706326
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CD28 costimulation prevents cell death during primary T cell activation.
Noel PJ, Boise LH, Green JM, Thompson CB
J Immunol. 1996
PubMed ID: 8752911
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Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function.
Kariv I, Truneh A, Sweet RW
J Immunol. 1996
PubMed ID: 8683128
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CD28 is required for germinal center formation.
Ferguson SE, Han S, Kelsoe G, Thompson CB
J Immunol. 1996
PubMed ID: 8648099
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Protection against lethal toxic shock by targeted disruption of the CD28 gene.
Saha B, Harlan DM, Lee KP, June CH, Abe R
J Exp Med. 1996
PubMed ID: 8676089
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Induction of unresponsiveness and impaired T cell expansion by staphylococcal enterotoxin B in CD28-deficient mice.
Mittrücker HW, Shahinian A, Bouchard D, Kündig TM, Mak TW
J Exp Med. 1996
PubMed ID: 8676068
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Two distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase association.
Pagès F, Ragueneau M, Klasen S, Battifora M, Couez D, Sweet R, Truneh A, Ward SG, Olive D
J Biol Chem. 1996
PubMed ID: 8621607
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Skin allograft rejection in CD28-deficient mice.
Kawai K, Shahinian A, Mak TW, Ohashi PS
Transplantation. 1996
PubMed ID: 8610339
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Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): analysis by site directed mutagenesis.
Truneh A, Reddy M, Ryan P, Lyn SD, Eichman C, Couez D, Hurle MR, Sekaly RP, Olive D, Sweet R
Mol Immunol. 1996
PubMed ID: 8649453
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Signal transduction by CD28 costimulatory receptor on T cells. B7-1 and B7-2 regulation of tyrosine kinase adaptor molecules.
Nunès JA, Truneh A, Olive D, Cantrell DA
J Biol Chem. 1996
PubMed ID: 8576157
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Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.
Spur NK, Bashir R, Bushby K, Cox A, Cox S, Hilde Brandt F, Hill N, Kao FT, Krols L, Marzella R, Miller N, Nothwang HG, Rocchi M, Sarfarazi M, Stratakis CA, Wallgren-Petterson C, Naylor S
Cytogenet Cell Genet. 1996
PubMed ID: 8751373
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CD28/B7 system of T cell costimulation.
Lenschow DJ, Walunas TL, Bluestone JA
Annu Rev Immunol. 1996
PubMed ID: 8717514
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Ligation of either CD2 or CD28 rescues CD4+ T cells from HIV-gp120-induced apoptosis.
Tuosto L, Piazza C, Moretti S, Modesti A, Greenlaw R, Lechler R, Lombardi G, Piccolella E
Eur J Immunol. 1995
PubMed ID: 7589092
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Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O
Nature. 1995
PubMed ID: 7566098
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Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28.
Peach RJ, Bajorath J, Naemura J, Leytze G, Greene J, Aruffo A, Linsley PS
J Biol Chem. 1995
PubMed ID: 7545666
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Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4.
Fargeas CA, Truneh A, Reddy M, Hurle M, Sweet R, Sékaly RP
J Exp Med. 1995
PubMed ID: 7544393
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Costimulation of CD4+ T cells via CD28 modulates human immunodeficiency virus type 1 infection and replication in vitro.
Smithgall MD, Wong JG, Linsley PS, Haffar OK
AIDS Res Hum Retroviruses. 1995
PubMed ID: 7492435
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HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71).
Chirmule N, McCloskey TW, Hu R, Kalyanaraman VS, Pahwa S
J Immunol. 1995
PubMed ID: 7541827
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CD43 is a murine T cell costimulatory receptor that functions independently of CD28.
Sperling AI, Green JM, Mosley RL, Smith PL, DiPaolo RJ, Klein JR, Bluestone JA, Thompson CB
J Exp Med. 1995
PubMed ID: 7790813
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Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response.
Lucas PJ, Negishi I, Nakayama K, Fields LE, Loh DY
J Immunol. 1995
PubMed ID: 7751626
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Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNAs are regulated with complex kinetics.
Umlauf SW, Beverly B, Lantz O, Schwartz RH
Mol Cell Biol. 1995
PubMed ID: 7539104
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Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester.
Tacke M, Clark GJ, Dallman MJ, Hünig T
J Immunol. 1995
PubMed ID: 7730618
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Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120.
Dianzani U, Bragardo M, Buonfiglio D, Redoglia V, Funaro A, Portoles P, Rojo J, Malavasi F, Pileri A
Eur J Immunol. 1995
PubMed ID: 7539755
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T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras.
Schneider H, Cai YC, Prasad KV, Shoelson SE, Rudd CE
Eur J Immunol. 1995
PubMed ID: 7737275
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Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation.
Abe R, Vandenberghe P, Craighead N, Smoot DS, Lee KP, June CH
J Immunol. 1995
PubMed ID: 7822814
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Cloning and sequencing of the rabbit gene encoding T-cell costimulatory molecules.
Isono T, Seto A
Immunogenetics. 1995
PubMed ID: 7642234
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Differential regulation of proto-oncogenes c-jun and c-fos in T lymphocytes activated through CD28.
Chatta GS, Spies AG, Chang S, Mize GJ, Linsley PS, Ledbetter JA, Morris DR
J Immunol. 1994
PubMed ID: 7989745
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Regulation of T helper cell responses in experimental murine schistosomiasis by IL-10. Effect on expression of B7 and B7-2 costimulatory molecules by macrophages.
Flores Villanueva PO, Reiser H, Stadecker MJ
J Immunol. 1994
PubMed ID: 7525726
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Expression of the B7/BB1 activation antigen and its ligand CD28 in T-cell-mediated skin diseases.
Simon JC, Dietrich A, Mielke V, Wuttig C, Vanscheidt W, Linsley PS, Schöpf E, Sterry W
J Invest Dermatol. 1994
PubMed ID: 7523532
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Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.
Kubin M, Kamoun M, Trinchieri G
J Exp Med. 1994
PubMed ID: 7516408
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In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice.
Blazar BR, Taylor PA, Linsley PS, Vallera DA
Blood. 1994
PubMed ID: 7515723
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Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule.
Chen C, Gault A, Shen L, Nabavi N
J Immunol. 1994
PubMed ID: 7513726
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CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase.
August A, Dupont B
Int Immunol. 1994
PubMed ID: 8080844
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Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function.
Hubbe M, Altevogt P
Eur J Immunol. 1994
PubMed ID: 8125140
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Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.
Truitt KE, Hicks CM, Imboden JB
J Exp Med. 1994
PubMed ID: 7509360
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Differential T cell costimulatory requirements in CD28-deficient mice.
Shahinian A, Pfeffer K, Lee KP, Kündig TM, Kishihara K, Wakeham A, Kawai K, Ohashi PS, Thompson CB, Mak TW
Science. 1993
PubMed ID: 7688139
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HIV-gp 160-induced T cell-dependent B cell differentiation. Role of T cell-B cell activation molecule and IL-6.
Chirmule N, Kalyanaraman VS, Lederman S, Oyaizu N, Yagura H, Yellin MJ, Chess L, Pahwa S
J Immunol. 1993
PubMed ID: 8450224
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The role of the CD28 receptor during T cell responses to antigen.
Linsley PS, Ledbetter JA
Annu Rev Immunol. 1993
PubMed ID: 8386518
-
CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.
Freeman GJ, Lombard DB, Gimmi CD, Brod SA, Lee K, Laning JC, Hafler DA, Dorf ME, Gray GS, Reiser H
J Immunol. 1992
PubMed ID: 1281186
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Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells.
Morse HC
J Immunol. 1992
PubMed ID: 1431091
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Identification and distribution of the costimulatory receptor CD28 in the mouse.
Gross JA, Callas E, Allison JP
J Immunol. 1992
PubMed ID: 1320641
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CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation.
Fraser JD, Newton ME, Weiss A
J Exp Med. 1992
PubMed ID: 1313075
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Signalling in human tumour infiltrating lymphocytes: the CD28 molecule is functional and is physically associated with the CD45R0 molecule.
Zocchi MR, Poggi A, Crosti F, Tongiani S, Rugarli C
Eur J Cancer. 1992
PubMed ID: 1355979
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Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16.
Colombo MP, Martinotti A, Howard TA, Schneider C, D'Eustachio P, Seldin MF
Mamm Genome. 1992
PubMed ID: 1347472
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Identification of a cDNA encoding the rat CD28 homologue.
Clark GJ, Dallman MJ
Immunogenetics. 1992
PubMed ID: 1309509
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A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx.
Ruegg CL, Strand M
Cell Immunol. 1991
PubMed ID: 1832084
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CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.
Harper K, Balzano C, Rouvier E, Mattéi MG, Luciani MF, Golstein P
J Immunol. 1991
PubMed ID: 1713603
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Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.
Linsley PS, Brady W, Grosmaire L, Aruffo A, Damle NK, Ledbetter JA
J Exp Med. 1991
PubMed ID: 1847722
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Cd28 and Ctla-4, two related members of the Ig supergene family, are tightly linked on proximal mouse chromosome 1.
Howard TA, Rochelle JM, Seldin MF
Immunogenetics. 1991
PubMed ID: 1671668
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The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity.
Lee KP, Taylor C, Petryniak B, Turka LA, June CH, Thompson CB
J Immunol. 1990
PubMed ID: 2162892
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The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression.
Gross JA, St John T, Allison JP
J Immunol. 1990
PubMed ID: 2157764
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Human CD28 and CTLA-4 Ig superfamily genes are located on chromosome 2 at bands q33-q34.
Lafage-Pochitaloff M, Costello R, Couez D, Simonetti J, Mannoni P, Mawas C, Olive D
Immunogenetics. 1990
PubMed ID: 2156778
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Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.
Aruffo A, Seed B
Proc Natl Acad Sci U S A. 1987
PubMed ID: 2825196
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Involvement of T44 molecules in an antigen-independent pathway of T cell activation. Analysis of the correlations to the T cell antigen-receptor complex.
Moretta A, Pantaleo G, Lopez-Botet M, Moretta L
J Exp Med. 1985
PubMed ID: 3875683
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Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen).
Hara T, Fu SM, Hansen JA
J Exp Med. 1985
PubMed ID: 3159820
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