Home NRXN1
|
(Human) GRCh37 - chr2:50145643..51259674 (1.11 Mb) View in Genome Browser
(Mouse) NCBIM37 - chr17:90432984..91492337 (16 Mb) View in Genome Browser
(Rat) RGSC3.4 - chr6:14050929..15354069 (1.30 Mb) View in Genome Browser
HaemAtlas Expression Table for NRXN1:|
Expression Legend
|
|
|
Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
| Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Expression Legend
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for NRXN1:The NRXN1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| NRXN1 | NXPH3 | HPRD | empirical | 9856994 |
| NRXN1 | NXPH2 | HPRD | empirical | 8699246 |
| NRXN1 | SYT2 | HPRD | empirical | 8901523 |
| NRXN1 | SYT9 | HPRD | empirical | 8901523 |
| NRXN1 | SYT6 | HPRD | empirical | 8901523 |
| NRXN1 | DLG4 | IntAct | empirical | 19455133 |
| NRXN1 | NLGN1 | HPRD, BioGRID | empirical | 8576240 14522992 |
| NRXN1 | RPH3A | HPRD | empirical | 8901523 |
| NRXN1 | MYO16 | HPRD, IntAct | empirical | 12421765 |
| NRXN1 | PDZD2 | HPRD, IntAct | empirical | 12421765 |
| NRXN1 | MACF1 | HPRD, IntAct | empirical | 12421765 |
| NRXN1 | SIPA1L1 | HPRD, IntAct | empirical | 12421765 |
| NRXN1 | SDCBP2 | HPRD | empirical | 11152476 |
| NRXN1 | GRID2 | IntAct | empirical | 20537373 |
| NRXN1 | NXPH1 | HPRD | empirical | 8699246 9856994 |
| NRXN1 | APBA1 | HPRD, MINT, BioGRID | empirical | 11036064 |
| NRXN1 | APBA2 | HPRD, BioGRID | empirical | 11036064 |
| NRXN1 | MLLT4 | MINT, BioGRID | empirical | 9707552 |
| NRXN1 | NLGN3 | HPRD, BioGRID | empirical | 8576240 9325340 |
| NRXN1 | SYTL2 | HPRD, IntAct | empirical | 11243866 |
| NRXN1 | NLGN2 | HPRD, BioGRID | empirical | 8576240 |
| NRXN1 | SYT13 | HPRD, BioGRID | empirical | 11171101 |
| NRXN1 | SYT1 | HPRD | empirical | 11243866 8901523 |
| NRXN1 | SYT4 | HPRD | empirical | 8901523 |
| NRXN1 | SYT5 | HPRD | empirical | 8901523 |
| NRXN1 | SYTL1 | HPRD, IntAct, BioGRID | empirical | 11243866 |
| NRXN1 | CASK | HPRD, MINT, IntAct, BioGRID | empirical | 8786425 11036064 18423203 |
| NRXN1 | CBLN1 | IntAct | empirical | 20537373 |
| NRXN1 | SYT7 | HPRD | empirical | 8901523 |
| NRXN1 | SYTL3 | HPRD, IntAct | empirical | 11243866 |
|
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
Type 1 Diabetes Publications: 1
-
Expression of neurexin, neuroligin and their cytoplasmic binding partners in the pancreatic {beta}-cells and the involvement of neuroligin in insulin secretion.
Suckow AT, Comoletti D, Waldrop MA, Mosedale M, Egodage S, Taylor P, Chessler SD
Endocrinology. 2008
PubMed ID: 18755801
Publications: 127
-
SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1.
Iijima T, Wu K, Witte H, Hanno-Iijima Y, Glatter T, Richard S, Scheiffele P
Cell. 2011
PubMed ID: 22196734
-
Compound heterozygous deletion of NRXN1 causing severe developmental delay with early onset epilepsy in two sisters.
Harrison V, Connell L, Hayesmoore J, McParland J, Pike MG, Blair E
Am J Med Genet A. 2011
PubMed ID: 21964664
-
The putative functional rs1045881 marker of neurexin-1 in schizophrenia and clozapine response.
Lett TA, Tiwari AK, Meltzer HY, Lieberman JA, Potkin SG, Voineskos AN, Kennedy JL, Müller DJ
Schizophr Res. 2011
PubMed ID: 21890328
-
Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia.
Gauthier J, Siddiqui TJ, Huashan P, Yokomaku D, Hamdan FF, Champagne N, Lapointe M, Spiegelman D, Noreau A, Lafrenière RG, Fathalli F, Joober R, Krebs MO, DeLisi LE, Mottron L, Fombonne E, Michaud JL, Drapeau P, Carbonetto S, Craig AM, Rouleau GA
Hum Genet. 2011
PubMed ID: 21424692
-
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
-
Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions.
Matsuda K, Yuzaki M
Eur J Neurosci. 2011
PubMed ID: 21410790
-
Resequencing and follow-up of neurexin 1 (NRXN1) in schizophrenia patients.
Mühleisen TW, Basmanav FB, Forstner AJ, Mattheisen M, Priebe L, Herms S, Breuer R, Moebus S, Nenadic I, Sauer H, Mössner R, Maier W, Rujescu D, Ludwig M, Rietschel M, Nöthen MM, Cichon S
Schizophr Res. 2011
PubMed ID: 21288692
-
Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons.
Joo JY, Lee SJ, Uemura T, Yoshida T, Yasumura M, Watanabe M, Mishina M
Biochem Biophys Res Commun. 2011
PubMed ID: 21356198
-
Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocytes in kidneys.
Saito A, Miyauchi N, Hashimoto T, Karasawa T, Han GD, Kayaba M, Sumi T, Tomita M, Ikezumi Y, Suzuki K, Koitabashi Y, Shimizu F, Kawachi H
Am J Physiol Regul Integr Comp Physiol. 2011
PubMed ID: 21048075
-
Expanding the clinical spectrum associated with defects in CNTNAP2 and NRXN1.
Gregor A, Albrecht B, Bader I, Bijlsma EK, Ekici AB, Engels H, Hackmann K, Horn D, Hoyer J, Klapecki J, Kohlhase J, Maystadt I, Nagl S, Prott E, Tinschert S, Ullmann R, Wohlleber E, Woods G, Reis A, Rauch A, Zweier C
BMC Med Genet. 2011
PubMed ID: 21827697
-
Neurexin-1 and frontal lobe white matter: an overlapping intermediate phenotype for schizophrenia and autism spectrum disorders.
Voineskos AN, Lett TA, Lerch JP, Tiwari AK, Ameis SH, Rajji TK, Müller DJ, Mulsant BH, Kennedy JL
PLoS One. 2011
PubMed ID: 21687627
-
Presenilin/γ-secretase regulates neurexin processing at synapses.
Saura CA, Servián-Morilla E, Scholl FG
PLoS One. 2011
PubMed ID: 21559374
-
A case-control association study of NRXN1 polymorphisms with schizophrenia in Chinese Han population.
Yue W, Yang Y, Zhang Y, Lu T, Hu X, Wang L, Ruan Y, Lv L, Zhang D
Behav Brain Funct. 2011
PubMed ID: 21477380
-
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
-
Differential dynamics and activity-dependent regulation of alpha- and beta-neurexins at developing GABAergic synapses.
Fu Y, Huang ZJ
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21149722
-
Differential expression of presynaptic genes in a rat model of postnatal hypoxia: relevance to schizophrenia.
Sommer JU, Schmitt A, Heck M, Schaeffer EL, Fendt M, Zink M, Nieselt K, Symons S, Petroianu G, Lex A, Herrera-Marschitz M, Spanagel R, Falkai P, Gebicke-Haerter PJ
Eur Arch Psychiatry Clin Neurosci. 2010
PubMed ID: 20945070
-
A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.
Verweij KJ, Zietsch BP, Medland SE, Gordon SD, Benyamin B, Nyholt DR, McEvoy BP, Sullivan PF, Heath AC, Madden PA, Henders AK, Montgomery GW, Martin NG, Wray NR
Biol Psychol. 2010
PubMed ID: 20691247
-
Neurexin-neuroligin cell adhesion complexes contribute to synaptotropic dendritogenesis via growth stabilization mechanisms in vivo.
Chen SX, Tari PK, She K, Haas K
Neuron. 2010
PubMed ID: 20869594
-
Influence of neurexin 1 (NRXN1) polymorphisms in clozapine response.
Souza RP, Meltzer HY, Lieberman JA, Le Foll B, Kennedy JL
Hum Psychopharmacol. 2010
PubMed ID: 20860064
-
Joint influence of small-effect genetic variants on human longevity.
Yashin AI, Wu D, Arbeev KG, Ukraintseva SV
Aging (Albany NY). 2010
PubMed ID: 20834067
-
Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions.
Leone P, Comoletti D, Ferracci G, Conrod S, Garcia SU, Taylor P, Bourne Y, Marchot P
EMBO J. 2010
PubMed ID: 20543817
-
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
-
Intragenic rearrangements in NRXN1 in three families with autism spectrum disorder, developmental delay, and speech delay.
Wiśniowiecka-Kowalnik B, Nesteruk M, Peters SU, Xia Z, Cooper ML, Savage S, Amato RS, Bader P, Browning MF, Haun CL, Duda AW, Cheung SW, Stankiewicz P
Am J Med Genet B Neuropsychiatr Genet. 2010
PubMed ID: 20162629
-
Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum.
Uemura T, Lee SJ, Yasumura M, Takeuchi T, Yoshida T, Ra M, Taguchi R, Sakimura K, Mishina M
Cell. 2010
PubMed ID: 20537373
-
Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders.
Ching MS, Shen Y, Tan WH, Jeste SS, Morrow EM, Chen X, Mukaddes NM, Yoo SY, Hanson E, Hundley R, Austin C, Becker RE, Berry GT, Driscoll K, Engle EC, Friedman S, Gusella JF, Hisama FM, Irons MB, Lafiosca T, LeClair E, Miller DT, Neessen M, Picker JD, Rappaport L, Rooney CM, Sarco DP, Stoler JM, Walsh CA, Wolff RR, Zhang T, Nasir RH, Wu BL, Children's Hospital Boston Genotype Phenotype Study Group
Am J Med Genet B Neuropsychiatr Genet. 2010
PubMed ID: 20468056
-
Association between neurexin 1 (NRXN1) polymorphisms and the smoking behavior of elderly Japanese.
Sato N, Kageyama S, Chen R, Suzuki M, Tanioka F, Kamo T, Shinmura K, Nozawa A, Sugimura H
Psychiatr Genet. 2010
PubMed ID: 20414139
-
Rare NRXN1 promoter variants in patients with schizophrenia.
Shah AK, Tioleco NM, Nolan K, Locker J, Groh K, Villa C, Stopkova P, Pedrosa E, Lachman HM
Neurosci Lett. 2010
PubMed ID: 20347009
-
TCF4, schizophrenia, and Pitt-Hopkins Syndrome.
Blake DJ, Forrest M, Chapman RM, Tinsley CL, O'Donovan MC, Owen MJ
Schizophr Bull. 2010
PubMed ID: 20421335
-
Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes.
Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL
Alcohol Clin Exp Res. 2010
PubMed ID: 20201926
-
Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility.
O'Dushlaine C, Kenny E, Heron E, Donohoe G, Gill M, Morris D, The International Schizophrenia Consortium, Corvin A
Mol Psychiatry. 2010
PubMed ID: 20157312
-
Three-way translocation involving MLL, MLLT1, and a novel third partner, NRXN1, in a patient with acute lymphoblastic leukemia and t(2;19;11) (p12;p13.3;q23).
Lee SG, Park TS, Won SC, Song J, Lee KA, Choi JR, Marschalek R, Meyer C
Cancer Genet Cytogenet. 2010
PubMed ID: 20113834
-
Copy number variation in schizophrenia in the Japanese population.
Ikeda M, Aleksic B, Kirov G, Kinoshita Y, Yamanouchi Y, Kitajima T, Kawashima K, Okochi T, Kishi T, Zaharieva I, Owen MJ, O'Donovan MC, Ozaki N, Iwata N
Biol Psychiatry. 2010
PubMed ID: 19880096
-
New copy number variations in schizophrenia.
Magri C, Sacchetti E, Traversa M, Valsecchi P, Gardella R, Bonvicini C, Minelli A, Gennarelli M, Barlati S
PLoS One. 2010
PubMed ID: 20967226
-
The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.
Bottos A, Destro E, Rissone A, Graziano S, Cordara G, Assenzio B, Cera MR, Mascia L, Bussolino F, Arese M
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19926856
-
CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila.
Zweier C, de Jong EK, Zweier M, Orrico A, Ousager LB, Collins AL, Bijlsma EK, Oortveld MA, Ekici AB, Reis A, Schenck A, Rauch A
Am J Hum Genet. 2009
PubMed ID: 19896112
-
Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments.
Etherton MR, Blaiss CA, Powell CM, Südhof TC
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19822762
-
A Genome-wide Study of Common SNPs and CNVs in Cognitive Performance in the CANTAB battery.
Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KL, Hunt P, Ge D, Heinzen EL, Maia JM, Shianna KV, Weale ME, Cherkas LF, Clement G, Spector TD, Gibson G, Goldstein DB
Hum Mol Genet. 2009
PubMed ID: 19734545
-
Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.
Guilmatre A, Dubourg C, Mosca AL, Legallic S, Goldenberg A, Drouin-Garraud V, Layet V, Rosier A, Briault S, Bonnet-Brilhault F, Laumonnier F, Odent S, Le Vacon G, Joly-Helas G, David V, Bendavid C, Pinoit JM, Henry C, Impallomeni C, Germano E, Tortorella G, Di Rosa G, Barthelemy C, Andres C, Faivre L, Frébourg T, Saugier Veber P, Campion D
Arch Gen Psychiatry. 2009
PubMed ID: 19736351
-
Neurexin 1 (NRXN1) deletions in schizophrenia.
Kirov G, Rujescu D, Ingason A, Collier DA, O'Donovan MC, Owen MJ
Schizophr Bull. 2009
PubMed ID: 19675094
-
Presynaptic targeting of alpha4beta 2 nicotinic acetylcholine receptors is regulated by neurexin-1beta.
Cheng SB, Amici SA, Ren XQ, McKay SB, Treuil MW, Lindstrom JM, Rao J, Anand R
J Biol Chem. 2009
PubMed ID: 19567877
-
Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: A preliminary study.
Novak G, Boukhadra J, Shaikh SA, Kennedy JL, Le Foll B
World J Biol Psychiatry. 2009
PubMed ID: 19658047
-
Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes.
Bucan M, Abrahams BS, Wang K, Glessner JT, Herman EI, Sonnenblick LI, Alvarez Retuerto AI, Imielinski M, Hadley D, Bradfield JP, Kim C, Gidaya NB, Lindquist I, Hutman T, Sigman M, Kustanovich V, Lajonchere CM, Singleton A, Kim J, Wassink TH, McMahon WM, Owley T, Sweeney JA, Coon H, Nurnberger JI, Li M, Cantor RM, Minshew NJ, Sutcliffe JS, Cook EH, Dawson G, Buxbaum JD, Grant SF, Schellenberg GD, Geschwind DH, Hakonarson H
PLoS Genet. 2009
PubMed ID: 19557195
-
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
-
A genome-wide investigation of SNPs and CNVs in schizophrenia.
Need AC, Ge D, Weale ME, Maia J, Feng S, Heinzen EL, Shianna KV, Yoon W, Kasperaviciūte D, Gennarelli M, Strittmatter WJ, Bonvicini C, Rossi G, Jayathilake K, Cola PA, McEvoy JP, Keefe RS, Fisher EM, St Jean PL, Giegling I, Hartmann AM, Möller HJ, Ruppert A, Fraser G, Crombie C, Middleton LT, St Clair D, Roses AD, Muglia P, Francks C, Rujescu D, Meltzer HY, Goldstein DB
PLoS Genet. 2009
PubMed ID: 19197363
-
Activity-independent and subunit-specific recruitment of functional AMPA receptors at neurexin/neuroligin contacts.
Heine M, Thoumine O, Mondin M, Tessier B, Giannone G, Choquet D
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19098102
-
Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A, The Psychiatric Genetics Network GroupComplete list of members appeared as Supplementary Note.
Am J Med Genet B Neuropsychiatr Genet. 2008
PubMed ID: 19086053
-
Polarized targeting of neurexins to synapses is regulated by their C-terminal sequences.
Fairless R, Masius H, Rohlmann A, Heupel K, Ahmad M, Reissner C, Dresbach T, Missler M
J Neurosci. 2008
PubMed ID: 19036990
-
Disruption of the neurexin 1 gene is associated with schizophrenia.
Rujescu D, Ingason A, Cichon S, Pietiläinen OP, Barnes MR, Toulopoulou T, Picchioni M, Vassos E, Ettinger U, Bramon E, Murray R, Ruggeri M, Tosato S, Bonetto C, Steinberg S, Sigurdsson E, Sigmundsson T, Petursson H, Gylfason A, Olason PI, Hardarsson G, Jonsdottir GA, Gustafsson O, Fossdal R, Giegling I, Möller HJ, Hartmann A, Hoffmann P, Crombie C, Fraser G, Walker N, Lonnqvist J, Suvisaari J, Tuulio-Henriksson A, Andreassen OA, Djurovic S, Hansen T, Werge T, Melle I, Kiemeney LA, Franke B, Buizer-Voskamp JE, Ophoff RA, GROUP Investigators, Rietschel M, Nöthen MM, Stefansson K, Peltonen L, St Clair D, Stefansson H, Collier DA
Hum Mol Genet. 2008
PubMed ID: 18945720
-
Recurrent CNVs disrupt three candidate genes in schizophrenia patients.
Vrijenhoek T, Buizer-Voskamp JE, van der Stelt I, Strengman E, Genetic Risk and Outcome in Psychosis (GROUP) Consortium, Sabatti C, Geurts van Kessel A, Brunner HG, Ophoff RA, Veltman JA
Am J Hum Genet. 2008
PubMed ID: 18940311
-
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
-
Neurexin 1alpha structural variants associated with autism.
Yan J, Noltner K, Feng J, Li W, Schroer R, Skinner C, Zeng W, Schwartz CE, Sommer SS
Neurosci Lett. 2008
PubMed ID: 18490107
-
Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers.
Nussbaum J, Xu Q, Payne TJ, Ma JZ, Huang W, Gelernter J, Li MD
Hum Mol Genet. 2008
PubMed ID: 18270208
-
A patient with vertebral, cognitive and behavioural abnormalities and a de novo deletion of NRXN1alpha.
Zahir FR, Baross A, Delaney AD, Eydoux P, Fernandes ND, Pugh T, Marra MA, Friedman JM
J Med Genet. 2008
PubMed ID: 18057082
-
Regulation of neurexin 1beta tertiary structure and ligand binding through alternative splicing.
Shen KC, Kuczynska DA, Wu IJ, Murray BH, Sheckler LR, Rudenko G
Structure. 2008
PubMed ID: 18334217
-
Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4.
Koehnke J, Jin X, Trbovic N, Katsamba PS, Brasch J, Ahlsen G, Scheiffele P, Honig B, Palmer AG, Shapiro L
Structure. 2008
PubMed ID: 18334216
-
Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia.
Kirov G, Gumus D, Chen W, Norton N, Georgieva L, Sari M, O'Donovan MC, Erdogan F, Owen MJ, Ropers HH, Ullmann R
Hum Mol Genet. 2008
PubMed ID: 17989066
-
Disruption of neurexin 1 associated with autism spectrum disorder.
Kim HG, Kishikawa S, Higgins AW, Seong IS, Donovan DJ, Shen Y, Lally E, Weiss LA, Najm J, Kutsche K, Descartes M, Holt L, Braddock S, Troxell R, Kaplan L, Volkmar F, Klin A, Tsatsanis K, Harris DJ, Noens I, Pauls DL, Daly MJ, MacDonald ME, Morton CC, Quade BJ, Gusella JF
Am J Hum Genet. 2008
PubMed ID: 18179900
-
Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions.
Chen X, Liu H, Shim AH, Focia PJ, He X
Nat Struct Mol Biol. 2008
PubMed ID: 18084303
-
Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions.
Araç D, Boucard AA, Ozkan E, Strop P, Newell E, Südhof TC, Brunger AT
Neuron. 2007
PubMed ID: 18093522
-
Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion.
Fabrichny IP, Leone P, Sulzenbacher G, Comoletti D, Miller MT, Taylor P, Bourne Y, Marchot P
Neuron. 2007
PubMed ID: 18093521
-
Neurexin Ibeta and neuroligin are localized on opposite membranes in mature central synapses.
Berninghausen O, Rahman MA, Silva JP, Davletov B, Hopkins C, Ushkaryov YA
J Neurochem. 2007
PubMed ID: 17868325
-
Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation.
Dudanova I, Tabuchi K, Rohlmann A, Südhof TC, Missler M
J Comp Neurol. 2007
PubMed ID: 17347997
-
Novel genes identified in a high-density genome wide association study for nicotine dependence.
Bierut LJ, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau OF, Swan GE, Rutter J, Bertelsen S, Fox L, Fugman D, Goate AM, Hinrichs AL, Konvicka K, Martin NG, Montgomery GW, Saccone NL, Saccone SF, Wang JC, Chase GA, Rice JP, Ballinger DG
Hum Mol Genet. 2007
PubMed ID: 17158188
-
High frequency of neurexin 1beta signal peptide structural variants in patients with autism.
Feng J, Schroer R, Yan J, Song W, Yang C, Bockholt A, Cook EH, Skinner C, Schwartz CE, Sommer SS
Neurosci Lett. 2006
PubMed ID: 17034946
-
Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins.
Comoletti D, Flynn RE, Boucard AA, Demeler B, Schirf V, Shi J, Jennings LL, Newlin HR, Südhof TC, Taylor P
Biochemistry. 2006
PubMed ID: 17042500
-
Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.
Dudanova I, Sedej S, Ahmad M, Masius H, Sargsyan V, Zhang W, Riedel D, Angenstein F, Schild D, Rupnik M, Missler M
J Neurosci. 2006
PubMed ID: 17035546
-
Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.
Bouwman J, Spijker S, Schut D, Wächtler B, Ylstra B, Smit AB, Verhage M
J Neurochem. 2006
PubMed ID: 16987237
-
A global genomic transcriptional code associated with CNS-expressed genes.
Bailey PJ, Klos JM, Andersson E, Karlén M, Källström M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J
Exp Cell Res. 2006
PubMed ID: 16919269
-
Structure function and splice site analysis of the synaptogenic activity of the neurexin-1 beta LNS domain.
Graf ER, Kang Y, Hauner AM, Craig AM
J Neurosci. 2006
PubMed ID: 16624946
-
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
-
alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction.
Sons MS, Busche N, Strenzke N, Moser T, Ernsberger U, Mooren FC, Zhang W, Ahmad M, Steffens H, Schomburg ED, Plomp JJ, Missler M
Neuroscience. 2006
PubMed ID: 16406382
-
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
-
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
-
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
-
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism.
Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC
J Biol Chem. 2005
PubMed ID: 15797875
-
Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity.
Levinson JN, Chéry N, Huang K, Wong TP, Gerrow K, Kang R, Prange O, Wang YT, El-Husseini A
J Biol Chem. 2005
PubMed ID: 15723836
-
Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels.
Zhang W, Rohlmann A, Sargsyan V, Aramuni G, Hammer RE, Südhof TC, Missler M
J Neurosci. 2005
PubMed ID: 15858059
-
Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr.
Zhou H, Xu Y, Yang Y, Huang A, Wu J, Shi Y
J Biol Chem. 2005
PubMed ID: 15684424
-
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
Nature. 2005
PubMed ID: 15815621
-
Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins.
Graf ER, Zhang X, Jin SX, Linhoff MW, Craig AM
Cell. 2004
PubMed ID: 15620359
-
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
-
The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing.
Comoletti D, De Jaco A, Jennings LL, Flynn RE, Gaietta G, Tsigelny I, Ellisman MH, Taylor P
J Neurosci. 2004
PubMed ID: 15152050
-
Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.
Kattenstroth G, Tantalaki E, Südhof TC, Gottmann K, Missler M
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14983056
-
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
-
Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta.
Comoletti D, Flynn R, Jennings LL, Chubykin A, Matsumura T, Hasegawa H, Südhof TC, Taylor P
J Biol Chem. 2003
PubMed ID: 14522992
-
Neurexin mediates the assembly of presynaptic terminals.
Dean C, Scholl FG, Choih J, DeMaria S, Berger J, Isacoff E, Scheiffele P
Nat Neurosci. 2003
PubMed ID: 12796785
-
Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.
Missler M, Zhang W, Rohlmann A, Kattenstroth G, Hammer RE, Gottmann K, Südhof TC
Nature. 2003
PubMed ID: 12827191
-
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
-
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
-
Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia.
Raghavendra Rao VL, Bowen KK, Dhodda VK, Song G, Franklin JL, Gavva NR, Dempsey RJ
J Neurochem. 2002
PubMed ID: 12437578
-
Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.
Nakayama M, Kikuno R, Ohara O
Genome Res. 2002
PubMed ID: 12421765
-
Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Okazaki N, Kikuno R, Ohara R, Inamoto S, Hara Y, Nagase T, Ohara O, Koga H
DNA Res. 2002
PubMed ID: 12465718
-
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T
DNA Res. 2002
PubMed ID: 12168954
-
CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein.
Tabuchi K, Biederer T, Butz S, Sudhof TC
J Neurosci. 2002
PubMed ID: 12040031
-
Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.
Tabuchi K, Südhof TC
Genomics. 2002
PubMed ID: 12036300
-
Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.
Rowen L, Young J, Birditt B, Kaur A, Madan A, Philipps DL, Qin S, Minx P, Wilson RK, Hood L, Graveley BR
Genomics. 2002
PubMed ID: 11944992
-
Genetic analysis of alpha-latrotoxin receptors reveals functional interdependence of CIRL/latrophilin 1 and neurexin 1 alpha.
Tobaben S, Südhof TC, Stahl B
J Biol Chem. 2002
PubMed ID: 11741895
-
A stoichiometric complex of neurexins and dystroglycan in brain.
Sugita S, Saito F, Tang J, Satz J, Campbell K, Südhof TC
J Cell Biol. 2001
PubMed ID: 11470830
-
The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity.
Koroll M, Rathjen FG, Volkmer H
J Biol Chem. 2001
PubMed ID: 11152476
-
Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins.
Fukuda M, Mikoshiba K
Biochem Biophys Res Commun. 2001
PubMed ID: 11243866
-
Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII).
Fukuda M, Mikoshiba K
Biochem J. 2001
PubMed ID: 11171101
-
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
-
Mints as adaptors. Direct binding to neurexins and recruitment of munc18.
Biederer T, Südhof TC
J Biol Chem. 2000
PubMed ID: 11036064
-
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
-
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
-
The structure of the ligand-binding domain of neurexin Ibeta: regulation of LNS domain function by alternative splicing.
Rudenko G, Nguyen T, Chelliah Y, Südhof TC, Deisenhofer J
Cell. 1999
PubMed ID: 10520997
-
Differential seizure-induced and developmental changes of neurexin expression.
Górecki DC, Szklarczyk A, Lukasiuk K, Kaczmarek L, Simons JP
Mol Cell Neurosci. 1999
PubMed ID: 10408888
-
Neurexins are functional alpha-latrotoxin receptors.
Sugita S, Khvochtev M, Südhof TC
Neuron. 1999
PubMed ID: 10197529
-
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
-
Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.
Missler M, Hammer RE, Südhof TC
J Biol Chem. 1998
PubMed ID: 9856994
-
CCG repeats in cDNAs from human brain.
Kleiderlein JJ, Nisson PE, Jessee J, Li WB, Becker KG, Derby ML, Ross CA, Margolis RL
Hum Genet. 1998
PubMed ID: 9921901
-
PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.
Hock B, Böhme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, Holland S, Pawson T, Rübsamen-Waigmann H, Strebhardt K
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9707552
-
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O
DNA Res. 1998
PubMed ID: 9628581
-
Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action.
Geppert M, Khvotchev M, Krasnoperov V, Goda Y, Missler M, Hammer RE, Ichtchenko K, Petrenko AG, Südhof TC
J Biol Chem. 1998
PubMed ID: 9430716
-
Neurexins: three genes and 1001 products.
Missler M, Südhof TC
Trends Genet. 1998
PubMed ID: 9448462
-
Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules.
Nguyen T, Südhof TC
J Biol Chem. 1997
PubMed ID: 9325340
-
Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration.
Andres C, Beeri R, Friedman A, Lev-Lehman E, Henis S, Timberg R, Shani M, Soreq H
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9223334
-
Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin.
Perin MS
Biochemistry. 1996
PubMed ID: 8901523
-
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
-
Structure and evolution of neurexophilin.
Petrenko AG, Ullrich B, Missler M, Krasnoperov V, Rosahl TW, Südhof TC
J Neurosci. 1996
PubMed ID: 8699246
-
CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.
Hata Y, Butz S, Südhof TC
J Neurosci. 1996
PubMed ID: 8786425
-
Structures, alternative splicing, and neurexin binding of multiple neuroligins.
Ichtchenko K, Nguyen T, Südhof TC
J Biol Chem. 1996
PubMed ID: 8576240
-
Neurexins are differentially expressed in the embryonic nervous system of mice.
Püschel AW, Betz H
J Neurosci. 1995
PubMed ID: 7722633
-
Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons.
Ullrich B, Ushkaryov YA, Südhof TC
Neuron. 1995
PubMed ID: 7695896
-
Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins.
Ushkaryov YA, Hata Y, Ichtchenko K, Moomaw C, Afendis S, Slaughter CA, Südhof TC
J Biol Chem. 1994
PubMed ID: 8163501
-
The COOH terminus of synaptotagmin mediates interaction with the neurexins.
Perin MS
J Biol Chem. 1994
PubMed ID: 8132583
-
Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin.
Ushkaryov YA, Petrenko AG, Geppert M, Südhof TC
Science. 1992
PubMed ID: 1621094
Model Organism Phenotype Links
|
Relevant resources: