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MAPKAPK2

Gene Description:   MAP kinase-activated protein kinase 2; mitogen-activated protein kinase-activated protein kinase 2 Synonyms:   Rps6kc1, MK2, AA960234, MAPKAPK2, Mapkapk2 Orthologs:   Human MAPKAPK2 (protein-coding), Mouse Mapkapk2 (protein-coding), Rat Mapkapk2 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid, KEGG Human-Rat: HomoloGene, MGD, RGD, Inparanoid, KEGG Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid, KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 3 Rat: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
1q32.1	Human	chr1:206802440..207049831	0.25	30	rs3024505

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd5.4	Mouse	chr1:77143053..147306684	70.16	608
Idd5.4a	Mouse	chr1:77143053..147306684	70.16	550

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 1q32.1 Orthologous Region	Mouse	chr1:132799083..133037227	0.24	5
Human 1q32.1 Orthologous Region	Rat	chr13:43856483..44092053	0.24	5

(Human) GRCh37 - chr1:206858289..206907628 (49.34 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr1:132950281..132994144 (43.86 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr13:43994943..44041587 (46.64 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for MAPKAPK2: The MAPKAPK2 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs MAPKAPK2   ARPC5   HPRD  empirical  12829704  MAPKAPK2   SMNDC1   IntAct  empirical  17353931  MAPKAPK2   HNRNPA0   HPRD  empirical  12456657  MAPKAPK2   CREB1   HPRD  empirical  8887554  MAPKAPK2   MAPK14   HPRD, IntAct, BioGRID, Reactome, Sanger Interaction Map  empirical  8846784  7592979  9768359  17255097  11042204  11551945  12171911  7535770  8622669  17395714  15287722  15345047  MAPKAPK2   PHC2   HPRD, BioGRID  empirical  15094067  MAPKAPK2   EGF   BioGRID  empirical  9687510  MAPKAPK2   AKT1   HPRD, BioGRID  empirical  11042204  MAPKAPK2   ESR1   IntAct  empirical  21182205  MAPKAPK2   ETV1   HPRD, BioGRID  empirical  11551945  MAPKAPK2   ISCU   Sanger Interaction Map  predicted  15345047  MAPKAPK2   ALOX5   HPRD  empirical  10779545  11844797  MAPKAPK2   EEF2K   HPRD  empirical  12171600  MAPKAPK2   HSF1   HPRD, IntAct  empirical  16278218  MAPKAPK2   HSPB1   HPRD, IntAct, BioGRID  empirical  7799959  1332886  11042204  21575178  MAPKAPK2   LIMK1   MINT  empirical  16456544  MAPKAPK2   LSP1   HPRD  empirical  8995217  MAPKAPK2   PINX1   IntAct  empirical  17353931  MAPKAPK2   LYAR   IntAct  empirical  17353931  MAPKAPK2   PRKCE   IntAct  empirical  11139474  MAPKAPK2   MAPK1   BioGRID  empirical  15094067  MAPKAPK2   MAPK11   Reactome  predicted  9768359  12171911  7535770  8622669  17395714  8846784  17255097  15287722  MAPKAPK2   SHC1   HPRD, BioGRID  empirical  15094067  MAPKAPK2   SRF   HPRD  empirical  10753652  8413226  10318869  12171911  MAPKAPK2   TCF3   HPRD  empirical  10781029  MAPKAPK2   TH   HPRD  empirical  6150037  11359875  7901013  MAPKAPK2   TSC2   HPRD, BioGRID  empirical  12582162  MAPKAPK2   YWHAZ   HPRD  empirical  12861023  MAPKAPK2   ZFP36   HPRD  empirical  14688255  MAPKAPK2   MAPKAPK2   HPRD  empirical  8846784  MAPKAPK2   BAG2   HPRD  empirical  15271996  MAPKAPK2   CDC25A   IntAct  empirical  17292828

View all

KEGG Network: 3   MAPK signaling pathway Human - 4010 Mouse - 4010 Rat - 4010 Neurotrophin signaling pathway Human - 4722 Mouse - 4722 Rat - 4722 VEGF signaling pathway Human - 4370 Mouse - 4370 Rat - 4370

Biocarta: 3   MAPKinase Signaling Pathway Human Mouse p38 MAPK Signaling Pathway Human Mouse Stress Induction of HSP Regulation Human Mouse

Reactome: 16   activated TAK1 mediates p38 MAPK activation REACT_21399 CREB phosphorylation REACT_12524 Hormone biosynthesis REACT_15314 Leukotriene synthesis REACT_15354 MAP kinases activation in TLR cascade REACT_21308 MAPK targets/ Nuclear events mediated by MAP kinases REACT_21328 Metabolism of lipids and lipoproteins REACT_22258 NGF signalling via TRKA from the plasma membrane REACT_12056 Nuclear Events (kinase and transcription factor activation) REACT_12433 p38MAPK events REACT_12065 Prostanoid metabolism REACT_15369 Signalling by NGF REACT_11061 Signalling to ERKs REACT_12058 Signalling to RAS REACT_12033 Toll Like Receptor 3 (TLR3) Cascade REACT_6783 TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade REACT_6782

NCI-Nature Pathway Interaction Database: 5   IL2-mediated signaling events Signaling events mediated by VEGFR1 and VEGFR2 Signaling mediated by p38-alpha and p38-beta Trk receptor signaling mediated by the MAPK pathway p38 signaling mediated by MAPKAP kinases

Gene Ontology: 32   MAPKKK cascade GO:0000165 Nucleotide binding GO:0000166 Activation of MAPK activity GO:0000187 Toll-like receptor signaling pathway GO:0002224 MyD88-dependent toll-like receptor signaling pathway GO:0002755 MyD88-independent toll-like receptor signaling pathway GO:0002756 Protein kinase activity GO:0004672 Protein serine/threonine kinase activity GO:0004674 Signal transducer activity GO:0004871 Protein binding GO:0005515 ATP binding GO:0005524 Nucleus GO:0005634 Nucleoplasm GO:0005654 Cytoplasm GO:0005737 Cytosol GO:0005829 Protein phosphorylation GO:0006468 Prostanoid metabolic process GO:0006692 Ras protein signal transduction GO:0007265 Toll signaling pathway GO:0008063 RNA metabolic process GO:0016070 MRNA metabolic process GO:0016071 Leukotriene biosynthetic process GO:0019370 Toll-like receptor 1 signaling pathway GO:0034130 Toll-like receptor 2 signaling pathway GO:0034134 Toll-like receptor 3 signaling pathway GO:0034138 Toll-like receptor 4 signaling pathway GO:0034142 Cellular response to vascular endothelial growth factor stimulus GO:0035924 Innate immune response GO:0045087 Vascular endothelial growth factor receptor signaling pathway GO:0048010 Nerve growth factor receptor signaling pathway GO:0048011 MRNA stabilization GO:0048255 Stress-activated MAPK cascade GO:0051403

	KEGG Network: 3 MAPK signaling pathway Human - 4010 Mouse - 4010 Rat - 4010 Neurotrophin signaling pathway Human - 4722 Mouse - 4722 Rat - 4722 VEGF signaling pathway Human - 4370 Mouse - 4370 Rat - 4370
	Biocarta: 3 MAPKinase Signaling Pathway Human Mouse p38 MAPK Signaling Pathway Human Mouse Stress Induction of HSP Regulation Human Mouse
	Reactome: 16 activated TAK1 mediates p38 MAPK activation REACT_21399 CREB phosphorylation REACT_12524 Hormone biosynthesis REACT_15314 Leukotriene synthesis REACT_15354 MAP kinases activation in TLR cascade REACT_21308 MAPK targets/ Nuclear events mediated by MAP kinases REACT_21328 Metabolism of lipids and lipoproteins REACT_22258 NGF signalling via TRKA from the plasma membrane REACT_12056 Nuclear Events (kinase and transcription factor activation) REACT_12433 p38MAPK events REACT_12065 Prostanoid metabolism REACT_15369 Signalling by NGF REACT_11061 Signalling to ERKs REACT_12058 Signalling to RAS REACT_12033 Toll Like Receptor 3 (TLR3) Cascade REACT_6783 TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade REACT_6782
	NCI-Nature Pathway Interaction Database: 5 IL2-mediated signaling events Signaling events mediated by VEGFR1 and VEGFR2 Signaling mediated by p38-alpha and p38-beta Trk receptor signaling mediated by the MAPK pathway p38 signaling mediated by MAPKAP kinases
	Gene Ontology: 32 MAPKKK cascade GO:0000165 Nucleotide binding GO:0000166 Activation of MAPK activity GO:0000187 Toll-like receptor signaling pathway GO:0002224 MyD88-dependent toll-like receptor signaling pathway GO:0002755 MyD88-independent toll-like receptor signaling pathway GO:0002756 Protein kinase activity GO:0004672 Protein serine/threonine kinase activity GO:0004674 Signal transducer activity GO:0004871 Protein binding GO:0005515 ATP binding GO:0005524 Nucleus GO:0005634 Nucleoplasm GO:0005654 Cytoplasm GO:0005737 Cytosol GO:0005829 Protein phosphorylation GO:0006468 Prostanoid metabolic process GO:0006692 Ras protein signal transduction GO:0007265 Toll signaling pathway GO:0008063 RNA metabolic process GO:0016070 MRNA metabolic process GO:0016071 Leukotriene biosynthetic process GO:0019370 Toll-like receptor 1 signaling pathway GO:0034130 Toll-like receptor 2 signaling pathway GO:0034134 Toll-like receptor 3 signaling pathway GO:0034138 Toll-like receptor 4 signaling pathway GO:0034142 Cellular response to vascular endothelial growth factor stimulus GO:0035924 Innate immune response GO:0045087 Vascular endothelial growth factor receptor signaling pathway GO:0048010 Nerve growth factor receptor signaling pathway GO:0048011 MRNA stabilization GO:0048255 Stress-activated MAPK cascade GO:0051403

Publications: 147

• Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory ef
  Ehlting C, Ronkina N, Böhmer O, Albrecht U, Bode KA, Lang KS, Kotlyarov A, Radzioch D, Gaestel M, Häussinger D, Bode JG
  J Biol Chem. 2011
  PubMed ID: 21586572
   
  
• Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation.
  MacKenzie KF, Wallace DA, Hill EV, Anthony DF, Henderson DJ, Houslay DM, Arthur JS, Baillie GS, Houslay MD
  Biochem J. 2011
  PubMed ID: 21323643
   
  
• Silencing mitogen-activated protein kinase-activated protein kinase-2 arrests inflammatory bone loss.
  Li Q, Yu H, Zinna R, Martin K, Herbert B, Liu A, Rossa C, Kirkwood KL
  J Pharmacol Exp Ther. 2011
  PubMed ID: 21139061
   
  
• MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation.
  Chang E, Heo KS, Woo CH, Lee H, Le NT, Thomas TN, Fujiwara K, Abe J
  Blood. 2011
  PubMed ID: 21131586
   
  
• Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: regulation of oxidative stress.
  Ebrahimian T, Li MW, Lemarié CA, Simeone SM, Pagano PJ, Gaestel M, Paradis P, Wassmann S, Schiffrin EL
  Hypertension. 2011
  PubMed ID: 21173344
   
  
• Initial characterization of the human central proteome.
  Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
  BMC Syst Biol. 2011
  PubMed ID: 21269460
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment.
  Clement SL, Scheckel C, Stoecklin G, Lykke-Andersen J
  Mol Cell Biol. 2011
  PubMed ID: 21078877
   
  
• p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins.
  Menon MB, Schwermann J, Singh AK, Franz-Wachtel M, Pabst O, Seidler U, Omary MB, Kotlyarov A, Gaestel M
  J Biol Chem. 2010
  PubMed ID: 20724476
   
  
• Mitogen-activated protein kinase-activated protein kinase 2 (MK2) contributes to secondary damage after spinal cord injury.
  Ghasemlou N, Lopez-Vales R, Lachance C, Thuraisingam T, Gaestel M, Radzioch D, David S
  J Neurosci. 2010
  PubMed ID: 20943915
   
  
• DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.
  Reinhardt HC, Hasskamp P, Schmedding I, Morandell S, van Vugt MA, Wang X, Linding R, Ong SE, Weaver D, Carr SA, Yaffe MB
  Mol Cell. 2010
  PubMed ID: 20932473
   
  
• MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment.
  Marchese FP, Aubareda A, Tudor C, Saklatvala J, Clark AR, Dean JL
  J Biol Chem. 2010
  PubMed ID: 20595389
   
  
• Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients.
  Coulthard LR, Taylor JC, Eyre S, Biologics in Rheumatoid Arthritis Genetics and Genomics, Robinson JI, Wilson AG, Isaacs JD, Hyrich K, Emery P, Barton A, Barrett JH, Morgan AW, McDermott MF
  Ann Rheum Dis. 2010
  PubMed ID: 20805296
   
  
• Mechanisms regulating the nuclear translocation of p38 MAP kinase.
  Gong X, Ming X, Deng P, Jiang Y
  J Cell Biochem. 2010
  PubMed ID: 20506250
   
  
• TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2.
  Gais P, Tiedje C, Altmayr F, Gaestel M, Weighardt H, Holzmann B
  J Immunol. 2010
  PubMed ID: 20375303
   
  
• MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.
  Streicher JM, Ren S, Herschman H, Wang Y
  Circ Res. 2010
  PubMed ID: 20339119
   
  
• The MAP kinase-activated protein kinase 2 (MK2) contributes to the Shiga toxin-induced inflammatory response.
  Saenz JB, Li J, Haslam DB
  Cell Microbiol. 2010
  PubMed ID: 19951368
   
  
• p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.
  Cannell IG, Kong YW, Johnston SJ, Chen ML, Collins HM, Dobbyn HC, Elia A, Kress TR, Dickens M, Clemens MJ, Heery DM, Gaestel M, Eilers M, Willis AE, Bushell M
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20212154
   
  
• Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation.
  Radtke S, Wüller S, Yang XP, Lippok BE, Mütze B, Mais C, de Leur HS, Bode JG, Gaestel M, Heinrich PC, Behrmann I, Schaper F, Hermanns HM
  J Cell Sci. 2010
  PubMed ID: 20200229
   
  
• MK2 signaling: lessons on tissue specificity in modulation of inflammation.
  Fyhrquist N, Matikainen S, Lauerma A
  J Invest Dermatol. 2010
  PubMed ID: 20081887
   
  
• The role of mitogen-activated protein kinase-activated protein kinase 2 in the p38/TNF-alpha pathway of systemic and cutaneous inflammation.
  Schottelius AJ, Zügel U, Döcke WD, Zollner TM, Röse L, Mengel A, Buchmann B, Becker A, Grütz G, Naundorf S, Friedrich A, Gaestel M, Asadullah K
  J Invest Dermatol. 2010
  PubMed ID: 19657354
   
  
• p38 mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity.
  Kumar B, Koul S, Petersen J, Khandrika L, Hwa JS, Meacham RB, Wilson S, Koul HK
  Cancer Res. 2010
  PubMed ID: 20068172
   
  
• MAPK-activated protein kinase 2 is required for mouse meiotic spindle assembly and kinetochore-microtubule attachment.
  Yuan J, Xu BZ, Qi ST, Tong JS, Wei L, Li M, Ouyang YC, Hou Y, Schatten H, Sun QY
  PLoS One. 2010
  PubMed ID: 20596525
   
  
• MAPKAPK-2 signaling is critical for cutaneous wound healing.
  Thuraisingam T, Xu YZ, Eadie K, Heravi M, Guiot MC, Greemberg R, Gaestel M, Radzioch D
  J Invest Dermatol. 2010
  PubMed ID: 19609314
   
  
• MK2 regulates the early stages of skin tumor promotion.
  Johansen C, Vestergaard C, Kragballe K, Kollias G, Gaestel M, Iversen L
  Carcinogenesis. 2009
  PubMed ID: 19808857
   
  
• Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib.
  Dumka D, Puri P, Carayol N, Lumby C, Balachandran H, Schuster K, Verma AK, Terada LS, Platanias LC, Parmar S
  Leuk Lymphoma. 2009
  PubMed ID: 19672773
   
  
• Regulation of HSP60 and the role of MK2 in a new model of severe experimental pancreatitis.
  Li YY, Ochs S, Gao ZR, Malo A, Chen CJ, Lv S, Gallmeier E, Göke B, Schäfer C
  Am J Physiol Gastrointest Liver Physiol. 2009
  PubMed ID: 20501446
   
  
• MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia.
  Gorog DA, Jabr RI, Tanno M, Sarafraz N, Clark JE, Fisher SG, Cao XB, Bellahcene M, Dighe K, Kabir AM, Quinlan RA, Kato K, Gaestel M, Marber MS, Heads RJ
  Cell Stress Chaperones. 2009
  PubMed ID: 19214782
   
  
• SAGE analysis highlights the importance of p53csv, ddx5, mapkapk2 and ranbp2 to multiple myeloma tumorigenesis.
  Felix RS, Colleoni GW, Caballero OL, Yamamoto M, Almeida MS, Andrade VC, Chauffaille Mde L, Silva WA, Begnami MD, Soares FA, Simpson AJ, Zago MA, Vettore AL
  Cancer Lett. 2009
  PubMed ID: 19171422
   
  
• MAPK-activated protein kinase 2 differentially regulates plasmodium falciparum glycosylphosphatidylinositol-induced production of tumor necrosis factor-{alpha} and interleukin-12 in macrophages.
  Zhu J, Wu X, Goel S, Gowda NM, Kumar S, Krishnegowda G, Mishra G, Weinberg R, Li G, Gaestel M, Muta T, Gowda DC
  J Biol Chem. 2009
  PubMed ID: 19359247
   
  
• MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells.
  Schwermann J, Rathinam C, Schubert M, Schumacher S, Noyan F, Koseki H, Kotlyarov A, Klein C, Gaestel M
  EMBO J. 2009
  PubMed ID: 19369945
   
  
• RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  J Biol Chem. 2009
  PubMed ID: 19224920
   
  
• Reduced oxazolone-induced skin inflammation in MAPKAP kinase 2 knockout mice.
  Funding AT, Johansen C, Gaestel M, Bibby BM, Lilleholt LL, Kragballe K, Iversen L
  J Invest Dermatol. 2009
  PubMed ID: 18987672
   
  
• Mdm2 affects genome stability independent of p53.
  Bouska A, Eischen CM
  Cancer Res. 2009
  PubMed ID: 19244108
   
  
• Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury.
  Damarla M, Hasan E, Boueiz A, Le A, Pae HH, Montouchet C, Kolb T, Simms T, Myers A, Kayyali US, Gaestel M, Peng X, Reddy SP, Damico R, Hassoun PM
  PLoS One. 2009
  PubMed ID: 19240800
   
  
• MAP-kinase-activated protein kinase 2 expression and activity is induced after neuronal depolarization.
  Thomas T, Hitti E, Kotlyarov A, Potschka H, Gaestel M
  Eur J Neurosci. 2008
  PubMed ID: 18702688
   
  
• Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase.
  Evans IM, Britton G, Zachary IC
  Cell Signal. 2008
  PubMed ID: 18440775
   
  
• MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation--relevance in a mouse model of Parkinson's disease.
  Thomas T, Timmer M, Cesnulevicius K, Hitti E, Kotlyarov A, Gaestel M
  J Neurochem. 2008
  PubMed ID: 18298661
   
  
• The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2.
  Maitra S, Chou CF, Luber CA, Lee KY, Mann M, Chen CY
  RNA. 2008
  PubMed ID: 18326031
   
  
• Systemic deficiency of the MAP kinase-activated protein kinase 2 reduces atherosclerosis in hypercholesterolemic mice.
  Jagavelu K, Tietge UJ, Gaestel M, Drexler H, Schieffer B, Bavendiek U
  Circ Res. 2007
  PubMed ID: 17885219
   
  
• Lack of MK2 inhibits myofibroblast formation and exacerbates pulmonary fibrosis.
  Liu T, Warburton RR, Guevara OE, Hill NS, Fanburg BL, Gaestel M, Kayyali US
  Am J Respir Cell Mol Biol. 2007
  PubMed ID: 17600313
   
  
• MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation.
  Gorska MM, Liang Q, Stafford SJ, Goplen N, Dharajiya N, Guo L, Sur S, Gaestel M, Alam R
  J Exp Med. 2007
  PubMed ID: 17576778
   
  
• Distinct role of MAPKAPK-2 in the regulation of TNF gene expression by Toll-like receptor 7 and 9 ligands.
  Thuraisingam T, Xu YZ, Moisan J, Lachance C, Garnon J, Di Marco S, Gaestel M, Radzioch D
  Mol Immunol. 2007
  PubMed ID: 17485113
   
  
• MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization.
  Wu Y, Zhan L, Ai Y, Hannigan M, Gaestel M, Huang CK, Madri JA
  Biochem Biophys Res Commun. 2007
  PubMed ID: 17481585
   
  
• Ischemic preconditioning involves dual cardio-protective axes with p38MAPK as upstream target.
  Nagy N, Shiroto K, Malik G, Huang CK, Gaestel M, Abdellatif M, Tosaki A, Maulik N, Das DK
  J Mol Cell Cardiol. 2007
  PubMed ID: 17397860
   
  
• Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer.
  ter Haar E, Prabhakar P, Prabakhar P, Liu X, Lepre C
  J Biol Chem. 2007
  PubMed ID: 17255097
   
  
• Patterns of somatic mutation in human cancer genomes.
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• MAPKAPK2 and HSP27 are downstream effectors of p38 MAP kinase-mediated matrix metalloproteinase type 2 activation and cell invasion in human prostate cancer.
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• Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element.
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• Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2.
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• Co-induction of alphaB-crystallin and MAPKAPK-2 in astrocytes in the penumbra after transient focal cerebral ischemia.
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• MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.
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• Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
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• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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• Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells.
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• MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding.
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• Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
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• Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.
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• MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils.
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• Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis.
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• Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding.
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• Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme.
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• The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
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• 5-Lipoxygenase activation by MAPKAPK-2 and ERKs.
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