CD8A

Summary Top Help

Gene Description:

CD8a molecule; CD8 antigen, alpha chain

Synonyms:

MAL, Lyt-2, Ly-B, Ly-35, Leu2, Cd8a, Ly-2, BB154331, p32, CD8A, CD8

Orthologs:

Human CD8A (protein-coding), Mouse Cd8a (protein-coding), Rat Cd8a (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 1

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm14	Rat	chr4:63276741..160891592	97.61	815

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr2:87011728..87035519 (23.79 kb) View in Genome Browser

(Mouse) NCBIM37 - chr6:71323421..71329165 (5.74 kb) View in Genome Browser

(Rat) RGSC3.4 - chr4:104589922..104594159 (4.24 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CD8A:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CD8A:

The CD8A interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
CD8A	SREK1	HPRD	empirical	14559993
CD8A	LAT	HPRD	empirical	10562325
CD8A	CACYBP	IntAct	empirical	21988832
CD8A	HLA-A	HPRD	empirical	10809759 9177355
CD8A	HLA-B	HPRD	empirical	9331948 10809759
CD8A	HLA-C	HPRD	empirical	10809759 12899833
CD8A	HLA-E	HPRD	empirical	10809759
CD8A	HLA-G	HPRD	empirical	1908512 10843658 10809759
CD8A	LCK	HPRD, IntAct	empirical	14500983 7664803
CD8A	LGALS1	HPRD	empirical	10490978
CD8A	B2M	HPRD	empirical	11914379
CD8A	PTPRC	HPRD	empirical	1834739
CD8A	PTPRCAP	IntAct	empirical	10318863
CD8A	SRSF1	HPRD	empirical	10022843
CD8A	CD3D	HPRD	empirical	12215456
CD8A	CD8A	HPRD	empirical	9177355
CD8A	CD8B	Reactome	predicted
CD8A	CDK1	IntAct	empirical	21988832

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 5

Biocarta: 3

Reactome: 1

NCI-Nature Pathway Interaction Database: 3

Gene Ontology: 20

Publications from PubMed Top Help

Type 1 Diabetes Publications: 9

Slc11a1 Enhances the Autoimmune Diabetogenic T-cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens.
Dai YD, Marrero IG, Gros P, Zaghouani H, Wicker LS, Sercarz EE
Diabetes. 2008
PubMed ID: 18984740
Mechanisms of PDL1-mediated regulation of autoimmune diabetes.
Guleria I, Gubbels Bupp M, Dada S, Fife B, Tang Q, Ansari MJ, Trikudanathan S, Vadivel N, Fiorina P, Yagita H, Azuma M, Atkinson M, Bluestone JA, Sayegh MH
Clin Immunol. 2007
PubMed ID: 17627890
NK cells promote islet allograft tolerance via a perforin-dependent mechanism.
Beilke JN, Kuhl NR, Van Kaer L, Gill RG
Nat Med. 2005
PubMed ID: 16155578
Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Pearson T, Markees TG, Serreze DV, Pierce MA, Marron MP, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL
J Immunol. 2003
PubMed ID: 12816997
Appropriate developmental expression of human CD8 beta in transgenic mice.
Kieffer LJ, Yan L, Hanke JH, Kavathas PB
J Immunol. 1997
PubMed ID: 9366416
A mechanism for the major histocompatibility complex-linked resistance to autoimmunity.
Schmidt D, Verdaguer J, Averill N, Santamaria P
J Exp Med. 1997
PubMed ID: 9314555
Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis.
Tada Y, Ho A, Koh DR, Mak TW
J Immunol. 1996
PubMed ID: 8666829
Autoimmune diabetes-prone NOD mice express the Lyt2 alpha (Lyt2.1) and Lyt3 alpha (Lyt3.1) alleles of CD8.
Johnson-Tardieu JM, Walworth EW, Cornelius JG, Ye X, Schuster SM, Peck AB
Immunogenetics. 1996
PubMed ID: 8537123
Expression of different CD8 isoforms on distinct human lymphocyte subpopulations.
Moebius U, Kober G, Griscelli AL, Hercend T, Meuer SC
Eur J Immunol. 1991
PubMed ID: 1831127

Publications: 507

Down-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins.
Heigele A, Schindler M, Gnanadurai CW, Leonard JA, Collins KL, Kirchhoff F
J Virol. 2012
PubMed ID: 22013062
Circulating CD8+CD56-perforin+ T cells are increased in multiple sclerosis patients.
Giovanni F, Domenico P, Alessandro M, Raffaele I, Viviana N, Katia PA, Paola BA
J Neuroimmunol. 2011
PubMed ID: 22001684
The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells.
Laugel B, Cole DK, Clement M, Wooldridge L, Price DA, Sewell AK
J Leukoc Biol. 2011
PubMed ID: 21954283
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L
Nature. 2011
PubMed ID: 22080947
An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells.
Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM
Immunity. 2011
PubMed ID: 22118527
Cd8 enhancer E8I and Runx factors regulate CD8α expression in activated CD8+ T cells.
Hassan H, Sakaguchi S, Tenno M, Kopf A, Boucheron N, Carpenter AC, Egawa T, Taniuchi I, Ellmeier W
Proc Natl Acad Sci U S A. 2011
PubMed ID: 22025728
Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence.
Nowell CS, Bredenkamp N, Tetélin S, Jin X, Tischner C, Vaidya H, Sheridan JM, Stenhouse FH, Heussen R, Smith AJ, Blackburn CC
PLoS Genet. 2011
PubMed ID: 22072979
Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8α and promote its ubiquitylation and endocytosis.
D'Agostino M, Tornillo G, Caporaso MG, Barone MV, Ghigo E, Bonatti S, Mottola G
J Cell Sci. 2011
PubMed ID: 22045731
Cutting edge: CD40-CD40 ligand pathway plays a critical CD8-intrinsic and -extrinsic role during rescue of exhausted CD8 T cells.
Bhadra R, Gigley JP, Khan IA
J Immunol. 2011
PubMed ID: 21949017
Cutting edge: expression of XCR1 defines mouse lymphoid-tissue resident and migratory dendritic cells of the CD8α+ type.
Crozat K, Tamoutounour S, Manh TP, Fossum E, Luche H, Ardouin L, Guilliams M, Azukizawa H, Bogen B, Malissen B, Henri S, Dalod M
J Immunol. 2011
PubMed ID: 21948982
CD8(+) T-cell reconstitution in recipients of umbilical cord blood transplantation and characteristics associated with leukemic relapse.
Merindol N, Champagne MA, Duval M, Soudeyns H
Blood. 2011
PubMed ID: 21813446
Plasticity of human CD8αα binding to peptide-HLA-A*2402.
Shi Y, Qi J, Iwamoto A, Gao GF
Mol Immunol. 2011
PubMed ID: 21645925
The earliest intrathymic precursors of CD8α(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells.
Luche H, Ardouin L, Teo P, See P, Henri S, Merad M, Ginhoux F, Malissen B
Eur J Immunol. 2011
PubMed ID: 21630253
Tumor necrosis factor alpha production from CD8+ T cells mediates oviduct pathological sequelae following primary genital Chlamydia muridarum infection.
Murthy AK, Li W, Chaganty BK, Kamalakaran S, Guentzel MN, Seshu J, Forsthuber TG, Zhong G, Arulanandam BP
Infect Immun. 2011
PubMed ID: 21536799
Inflammatory cytokines determine the susceptibility of human CD8 T cells to Fas-mediated activation-induced cell death through modulation of FasL and c-FLIP(S) expression.
von Rossum A, Krall R, Escalante NK, Choy JC
J Biol Chem. 2011
PubMed ID: 21518761
Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens.
Dragovic SM, Hill T, Christianson GJ, Kim S, Elliott T, Scott D, Roopenian DC, Van Kaer L, Joyce S
J Immunol. 2011
PubMed ID: 21572029
CDK6 kinase activity is required for thymocyte development.
Hu MG, Deshpande A, Schlichting N, Hinds EA, Mao C, Dose M, Hu GF, Van Etten RA, Gounari F, Hinds PW
Blood. 2011
PubMed ID: 21508411
NFIL3/E4BP4 is a key transcription factor for CD8α⁺ dendritic cell development.
Kashiwada M, Pham NL, Pewe LL, Harty JT, Rothman PB
Blood. 2011
PubMed ID: 21474667
A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity.
Fujimoto K, Karuppuchamy T, Takemura N, Shimohigoshi M, Machida T, Haseda Y, Aoshi T, Ishii KJ, Akira S, Uematsu S
J Immunol. 2011
PubMed ID: 21525388
Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development.
Harker N, Garefalaki A, Menzel U, Ktistaki E, Naito T, Georgopoulos K, Kioussis D
J Immunol. 2011
PubMed ID: 21515796
Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors.
Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ
Cancer Res. 2011
PubMed ID: 21430066
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.
Motomura Y, Kitamura H, Hijikata A, Matsunaga Y, Matsumoto K, Inoue H, Atarashi K, Hori S, Watarai H, Zhu J, Taniguchi M, Kubo M
Nat Immunol. 2011
PubMed ID: 21460847
Flt3L-mobilized dendritic cells bearing H2-Kbm1 apoptotic cells do not induce cross-tolerance to CD8+ T cells across a class I MHC mismatched barrier.
del Rio ML, Cote-Sierra J, Rodriguez-Barbosa JI
Transpl Int. 2011
PubMed ID: 21276089
Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells.
Benson HL, Mobashery S, Chang M, Kheradmand F, Hong JS, Smith GN, Shilling RA, Wilkes DS
Am J Respir Cell Mol Biol. 2011
PubMed ID: 20639459
Role of CD4 and CD8 T-lymphocytes, B-lymphocytes and Natural Killer cells in the prediction of radiation-induced late toxicity in cervical cancer patients.
Bordón E, Henríquez-Hernández LA, Lara PC, Pinar B, Rodríguez-Gallego C, Lloret M
Int J Radiat Biol. 2011
PubMed ID: 21142701
RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation.
Collins A, Hewitt SL, Chaumeil J, Sellars M, Micsinai M, Allinne J, Parisi F, Nora EP, Bolland DJ, Corcoran AE, Kluger Y, Bosselut R, Ellmeier W, Chong MM, Littman DR, Skok JA
Immunity. 2011
PubMed ID: 21435585
Intrinsic requirement for the vitamin D receptor in the development of CD8αα-expressing T cells.
Bruce D, Cantorna MT
J Immunol. 2011
PubMed ID: 21270396
CD4 and CD8 T cell immune activation during chronic HIV infection: roles of homeostasis, HIV, type I IFN, and IL-7.
Catalfamo M, Wilhelm C, Tcheung L, Proschan M, Friesen T, Park JH, Adelsberger J, Baseler M, Maldarelli F, Davey R, Roby G, Rehm C, Lane C
J Immunol. 2011
PubMed ID: 21257970
CpG promotes cross-presentation of dead cell-associated antigens by pre-CD8α+ dendritic dells.
de Brito C, Tomkowiak M, Ghittoni R, Caux C, Leverrier Y, Marvel J
J Immunol. 2011
PubMed ID: 21187449
Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins.
Atibalentja DF, Murphy KM, Unanue ER
J Immunol. 2011
PubMed ID: 21178002
Type I IFN substitutes for T cell help during viral infections.
Wiesel M, Kratky W, Oxenius A
J Immunol. 2011
PubMed ID: 21160039
Endogenous collagen peptide activation of CD1d-restricted NKT cells ameliorates tissue-specific inflammation in mice.
Liu Y, Teige A, Mondoc E, Ibrahim S, Holmdahl R, Issazadeh-Navikas S
J Clin Invest. 2011
PubMed ID: 21157037
SPARC, FOXP3, CD8 and CD45 correlation with disease recurrence and long-term disease-free survival in colorectal cancer.
Chew A, Salama P, Robbshaw A, Klopcic B, Zeps N, Platell C, Lawrance IC
PLoS One. 2011
PubMed ID: 21818290
Breakdown of the blood-brain barrier during tick-borne encephalitis in mice is not dependent on CD8+ T-cells.
Růžek D, Salát J, Singh SK, Kopecký J
PLoS One. 2011
PubMed ID: 21629771
Interplay between CD8α+ dendritic cells and monocytes in response to Listeria monocytogenes infection attenuates T cell responses.
Kapadia D, Sadikovic A, Vanloubbeeck Y, Brockstedt D, Fong L
PLoS One. 2011
PubMed ID: 21559416
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in mice.
Weber SE, Tian H, Pirofski LA
J Immunol. 2011
PubMed ID: 21135172
CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease.
Joetham A, Okamoto M, Takeda K, Schedel M, Ohnishi H, Dakhama A, Gelfand EW
J Immunol. 2011
PubMed ID: 21115736
TL and CD8αα: Enigmatic partners in mucosal immunity.
Olivares-Villagómez D, Van Kaer L
Immunol Lett. 2010
PubMed ID: 20850477
siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen-specific CD8+ T cells.
Hobo W, Maas F, Adisty N, de Witte T, Schaap N, van der Voort R, Dolstra H
Blood. 2010
PubMed ID: 20682852
TIM-3: a novel regulatory molecule of alloimmune activation.
Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N
J Immunol. 2010
PubMed ID: 20956339
Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets.
Hislop AD, Palendira U, Leese AM, Arkwright PD, Rohrlich PS, Tangye SG, Gaspar HB, Lankester AC, Moretta A, Rickinson AB
Blood. 2010
PubMed ID: 20644117
[Expression and significance of gp96 and immune-related gene CTLA-4, CD8 in lung cancer tissues].
Zheng H, Li Y, Wang X, Zhang X, Wang X
Zhongguo Fei Ai Za Zhi. 2010
PubMed ID: 20704820
CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells.
Bar-On L, Birnberg T, Lewis KL, Edelson BT, Bruder D, Hildner K, Buer J, Murphy KM, Reizis B, Jung S
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20679228
Hematopoietic progenitor cell regulation by CD4+CD25+ T cells.
Urbieta M, Barao I, Jones M, Jurecic R, Panoskaltsis-Mortari A, Blazar BR, Murphy WJ, Levy RB
Blood. 2010
PubMed ID: 20200356
CD8 locus nuclear dynamics during thymocyte development.
Ktistaki E, Garefalaki A, Williams A, Andrews SR, Bell DM, Foster KE, Spilianakis CG, Flavell RA, Kosyakova N, Trifonov V, Liehr T, Kioussis D
J Immunol. 2010
PubMed ID: 20404270
Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection.
Engel I, Hammond K, Sullivan BA, He X, Taniuchi I, Kappes D, Kronenberg M
J Exp Med. 2010
PubMed ID: 20404101
The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes.
Sakaguchi S, Hombauer M, Bilic I, Naoe Y, Schebesta A, Taniuchi I, Ellmeier W
Nat Immunol. 2010
PubMed ID: 20383150
Dendritic cells and Stat3 are essential for CD137-induced CD8 T cell activation-induced cell death.
Zhang B, Zhang Y, Niu L, Vella AT, Mittler RS
J Immunol. 2010
PubMed ID: 20351189
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs.
Semmling V, Lukacs-Kornek V, Thaiss CA, Quast T, Hochheiser K, Panzer U, Rossjohn J, Perlmutter P, Cao J, Godfrey DI, Savage PB, Knolle PA, Kolanus W, Förster I, Kurts C
Nat Immunol. 2010
PubMed ID: 20190758
Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice.
Barnes MJ, Aksoylar H, Krebs P, Bourdeau T, Arnold CN, Xia Y, Khovananth K, Engel I, Sovath S, Lampe K, Laws E, Saunders A, Butcher GW, Kronenberg M, Steinbrecher K, Hildeman D, Grimes HL, Beutler B, Hoebe K
J Immunol. 2010
PubMed ID: 20190135
An active CD8alpha/pMHCI interaction is required for CD8 single positive thymocyte differentiation.
Kang YJ, Wang X, Lin SJ, Hsu YM, Chang HC
Eur J Immunol. 2010
PubMed ID: 19950178
Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.
Chen JL, Morgan AJ, Stewart-Jones G, Shepherd D, Bossi G, Wooldridge L, Hutchinson SL, Sewell AK, Griffiths GM, van der Merwe PA, Jones EY, Galione A, Cerundolo V
J Immunol. 2010
PubMed ID: 20053942
Commensal microbiota and CD8+ T cells shape the formation of invariant NKT cells.
Wei B, Wingender G, Fujiwara D, Chen DY, McPherson M, Brewer S, Borneman J, Kronenberg M, Braun J
J Immunol. 2010
PubMed ID: 20048124
IL-6 positively regulates Foxp3+CD8+ T cells in vivo.
Nakagawa T, Tsuruoka M, Ogura H, Okuyama Y, Arima Y, Hirano T, Murakami M
Int Immunol. 2010
PubMed ID: 20042455
Immune effectors required for hepatitis B virus clearance.
Yang PL, Althage A, Chung J, Maier H, Wieland S, Isogawa M, Chisari FV
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20080755
Caspase-3 is transiently activated without cell death during early antigen driven expansion of CD8(+) T cells in vivo.
McComb S, Mulligan R, Sad S
PLoS One. 2010
PubMed ID: 21203525
Liposome-coupled antigens are internalized by antigen-presenting cells via pinocytosis and cross-presented to CD8 T cells.
Tanaka Y, Taneichi M, Kasai M, Kakiuchi T, Uchida T
PLoS One. 2010
PubMed ID: 21179411
GATA-3 is required for early T lineage progenitor development.
Hosoya T, Kuroha T, Moriguchi T, Cummings D, Maillard I, Lim KC, Engel JD
J Exp Med. 2009
PubMed ID: 19934022
IFN-gamma expressed by T cells regulates the persistence of antigen presentation by limiting the survival of dendritic cells.
Russell MS, Dudani R, Krishnan L, Sad S
J Immunol. 2009
PubMed ID: 19923462
Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens.
Farrand KJ, Dickgreber N, Stoitzner P, Ronchese F, Petersen TR, Hermans IF
J Immunol. 2009
PubMed ID: 19923446
Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms.
Chen ML, Yan BS, Kozoriz D, Weiner HL
Eur J Immunol. 2009
PubMed ID: 19768696
CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help.
Nakanishi Y, Lu B, Gerard C, Iwasaki A
Nature. 2009
PubMed ID: 19898495
The CD4(+)CD8(+) and CD4(+) subsets of FOXP3(+) thymocytes differ in their response to growth factor deprivation or stimulation.
Lehtoviita A, Rossi LH, Kekäläinen E, Sairanen H, Arstila TP
Scand J Immunol. 2009
PubMed ID: 19751272
Self-class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels.
Takada K, Jameson SC
J Exp Med. 2009
PubMed ID: 19752186
T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling.
Terauchi M, Li JY, Bedi B, Baek KH, Tawfeek H, Galley S, Gilbert L, Nanes MS, Zayzafoon M, Guldberg R, Lamar DL, Singer MA, Lane TF, Kronenberg HM, Weitzmann MN, Pacifici R
Cell Metab. 2009
PubMed ID: 19723499
Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury.
Venet F, Chung CS, Huang X, Lomas-Neira J, Chen Y, Ayala A
J Immunol. 2009
PubMed ID: 19641139
Differential effects of dendritic cell transfer on airway hyperresponsiveness and inflammation.
Koya T, Matsuda H, Matsubara S, Miyahara N, Dakhama A, Takeda K, Gelfand EW
Am J Respir Cell Mol Biol. 2009
PubMed ID: 19151321
Structural basis of the CD8 alpha beta/MHC class I interaction: focused recognition orients CD8 beta to a T cell proximal position.
Wang R, Natarajan K, Margulies DH
J Immunol. 2009
PubMed ID: 19625641
CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.
DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N, Coussens LM
Cancer Cell. 2009
PubMed ID: 19647220
Themis, a T cell-specific protein important for late thymocyte development.
Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE
Nat Immunol. 2009
PubMed ID: 19597498
Spondylarthritis in HLA-B27/human beta2-microglobulin-transgenic rats is not prevented by lack of CD8.
Taurog JD, Dorris ML, Satumtira N, Tran TM, Sharma R, Dressel R, van den Brandt J, Reichardt HM
Arthritis Rheum. 2009
PubMed ID: 19565478
CD11c+CD8alpha+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis.
Dunne PJ, Moran B, Cummins RC, Mills KH
J Immunol. 2009
PubMed ID: 19542451
Glycosyltransferase function in core 2-type protein O glycosylation.
Stone EL, Ismail MN, Lee SH, Luu Y, Ramirez K, Haslam SM, Ho SB, Dell A, Fukuda M, Marth JD
Mol Cell Biol. 2009
PubMed ID: 19349303
Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.
Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH, Sayegh MH
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19528638
A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transduction.
Clarke RL, Thiemann S, Refaeli Y, Werlen G, Potter TA
Eur J Immunol. 2009
PubMed ID: 19449311
CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis.
Stromberg PE, Woolsey CA, Clark AT, Clark JA, Turnbull IR, McConnell KW, Chang KC, Chung CS, Ayala A, Buchman TG, Hotchkiss RS, Coopersmith CM
FASEB J. 2009
PubMed ID: 19158156
Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii.
Schaeffer M, Han SJ, Chtanova T, van Dooren GG, Herzmark P, Chen Y, Roysam B, Striepen B, Robey EA
J Immunol. 2009
PubMed ID: 19414791
CD8 T cells producing IL-17 and IFN-gamma initiate the innate immune response required for responses to antigen skin challenge.
Kish DD, Li X, Fairchild RL
J Immunol. 2009
PubMed ID: 19414746
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis.
Zhang S, Bernard D, Khan WI, Kaplan MH, Bramson JL, Wan Y
Eur J Immunol. 2009
PubMed ID: 19338001
Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects against graft-versus-host disease.
Pillai AB, George TI, Dutt S, Strober S
Blood. 2009
PubMed ID: 19221040
Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity.
Fujii S, Goto A, Shimizu K
Blood. 2009
PubMed ID: 19164596
Peripheral blood flow cytometry based diagnosis in primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma: implications for more extensive use.
Benetatos L, Dova L, Baxevanos G, Kolaitis NI, Bourantas KL, Vartholomatos G
Cytometry B Clin Cytom. 2009
PubMed ID: 18956469
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance.
Friedline RH, Brown DS, Nguyen H, Kornfeld H, Lee J, Zhang Y, Appleby M, Der SD, Kang J, Chambers CA
J Exp Med. 2009
PubMed ID: 19188497
CD8beta knockout mice mount normal anti-viral CD8+ T cell responses--but why?
Angelov GS, Guillaume P, Luescher IF
Int Immunol. 2009
PubMed ID: 19088062
MyD88 intrinsically regulates CD4 T-cell responses.
Zhou S, Kurt-Jones EA, Cerny AM, Chan M, Bronson RT, Finberg RW
J Virol. 2009
PubMed ID: 19052080
Salmonella induces death of CD8alpha(+) dendritic cells but not CD11c(int)CD11b(+) inflammatory cells in vivo via MyD88 and TNFR1.
Sundquist M, Wick MJ
J Leukoc Biol. 2009
PubMed ID: 19004989
T cell-derived lymphotoxin regulates liver regeneration.
Tumanov AV, Koroleva EP, Christiansen PA, Khan MA, Ruddy MJ, Burnette B, Papa S, Franzoso G, Nedospasov SA, Fu YX, Anders RA
Gastroenterology. 2009
PubMed ID: 18952083
Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice.
Oakley MS, Majam V, Mahajan B, Gerald N, Anantharaman V, Ward JM, Faucette LJ, McCutchan TF, Zheng H, Terabe M, Berzofsky JA, Aravind L, Kumar S
PLoS One. 2009
PubMed ID: 19710907
Potential roles of a special CD8 alpha alpha+ cell population and CC chemokine thymus-expressed chemokine in ovulation related inflammation.
Zhou C, Wu J, Borillo J, Torres L, McMahon J, Lou YH
J Immunol. 2009
PubMed ID: 19109193
An essential role for the stalk region of CD8 beta in the coreceptor function of CD8.
Rettig L, McNeill L, Sarner N, Guillaume P, Luescher I, Tolaini M, Kioussis D, Zamoyska R
J Immunol. 2009
PubMed ID: 19109142
Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.
Brochard V, Combadière B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D, Callebert J, Launay JM, Duyckaerts C, Flavell RA, Hirsch EC, Hunot S
J Clin Invest. 2009
PubMed ID: 19104149
Lymph sacs are not required for the initiation of lymph node formation.
Vondenhoff MF, van de Pavert SA, Dillard ME, Greuter M, Goverse G, Oliver G, Mebius RE
Development. 2009
PubMed ID: 19060331
The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I.
Shore DA, Issafras H, Landais E, Teyton L, Wilson IA
J Mol Biol. 2008
PubMed ID: 18929574
Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice.
Yu S, Bruce D, Froicu M, Weaver V, Cantorna MT
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19095793
Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells.
Wei B, Su TT, Dalwadi H, Stephan RP, Fujiwara D, Huang TT, Brewer S, Chen L, Arditi M, Borneman J, Rawlings DJ, Braun J
Eur J Immunol. 2008
PubMed ID: 19009526
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.
Shiow LR, Roadcap DW, Paris K, Watson SR, Grigorova IL, Lebet T, An J, Xu Y, Jenne CN, Föger N, Sorensen RU, Goodnow CC, Bear JE, Puck JM, Cyster JG
Nat Immunol. 2008
PubMed ID: 18836449
Tumor antigen-specific T-cells are Present in the CD8alphaalpha+ T-cell effector-memory pool.
Magalhaes I, Vudattu NK, Jäger E, Maeurer MJ
J Immunother. 2008
PubMed ID: 18833003
Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells.
Wang L, Wildt KF, Zhu J, Zhang X, Feigenbaum L, Tessarollo L, Paul WE, Fowlkes BJ, Bosselut R
Nat Immunol. 2008
PubMed ID: 18776904
Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency.
Mott KR, Underhill D, Wechsler SL, Ghiasi H
J Virol. 2008
PubMed ID: 18667491
Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice.
Oakley MS, McCutchan TF, Anantharaman V, Ward JM, Faucette L, Erexson C, Mahajan B, Zheng H, Majam V, Aravind L, Kumar S
Infect Immun. 2008
PubMed ID: 18644885
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta T, Takahama Y, Inoue J
Immunity. 2008
PubMed ID: 18799149
Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection.
Das A, Hoare M, Davies N, Lopes AR, Dunn C, Kennedy PT, Alexander G, Finney H, Lawson A, Plunkett FJ, Bertoletti A, Akbar AN, Maini MK
J Exp Med. 2008
PubMed ID: 18695005
CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 production.
Wong KL, Lew FC, MacAry PA, Kemeny DM
Eur J Immunol. 2008
PubMed ID: 18600823
Natural killer cells recruited into lymph nodes inhibit alloreactive T-cell activation through perforin-mediated killing of donor allogeneic dendritic cells.
Laffont S, Seillet C, Ortaldo J, Coudert JD, Guéry JC
Blood. 2008
PubMed ID: 18505782
Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses.
Hashiguchi M, Kobori H, Ritprajak P, Kamimura Y, Kozono H, Azuma M
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18650384
Essential role for Nix in autophagic maturation of erythroid cells.
Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J
Nature. 2008
PubMed ID: 18454133
CD8+CD28-, suppressive T cells in systemic lupus erythematosus.
Tulunay A, Yavuz S, Direskeneli H, Eksioglu-Demiralp E
Lupus. 2008
PubMed ID: 18625635
The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation.
Mallaun M, Naeher D, Daniels MA, Yachi PP, Hausmann B, Luescher IF, Gascoigne NR, Palmer E
J Immunol. 2008
PubMed ID: 18523287
Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II.
Riddle DS, Miller PJ, Vincent BG, Kepler TB, Maile R, Frelinger JA, Collins EJ
Eur J Immunol. 2008
PubMed ID: 18465769
CD4+ T lymphocytes mediate hypercholesterolemia-induced endothelial dysfunction via a NAD(P)H oxidase-dependent mechanism.
Wolfort RM, Stokes KY, Granger DN
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 18408127
Antagonistic roles of CD4+ and CD8+ T-cells in 7,12-dimethylbenz(a)anthracene cutaneous carcinogenesis.
Yusuf N, Nasti TH, Katiyar SK, Jacobs MK, Seibert MD, Ginsburg AC, Timares L, Xu H, Elmets CA
Cancer Res. 2008
PubMed ID: 18483278
Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17.
Nam JS, Terabe M, Kang MJ, Chae H, Voong N, Yang YA, Laurence A, Michalowska A, Mamura M, Lonning S, Berzofsky JA, Wakefield LM
Cancer Res. 2008
PubMed ID: 18483277
Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation.
Okamoto M, Takeda K, Joetham A, Ohnishi H, Matsuda H, Swasey CH, Swanson BJ, Yasutomo K, Dakhama A, Gelfand EW
J Exp Med. 2008
PubMed ID: 18426985
Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection.
Sun K, Metzger DW
Nat Med. 2008
PubMed ID: 18438414
Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes.
Wang T, Chen L, Ahmed E, Ma L, Yin D, Zhou P, Shen J, Xu H, Wang CR, Alegre ML, Chong AS
J Immunol. 2008
PubMed ID: 18424719
Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection.
Lopes AR, Kellam P, Das A, Dunn C, Kwan A, Turner J, Peppa D, Gilson RJ, Gehring A, Bertoletti A, Maini MK
J Clin Invest. 2008
PubMed ID: 18398508
Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptors.
Andrews NP, Pack CD, Lukacher AE
J Virol. 2008
PubMed ID: 18337581
Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus.
Iannacone M, Sitia G, Isogawa M, Whitmire JK, Marchese P, Chisari FV, Ruggeri ZM, Guidotti LG
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18184798
Identification of CD4(-)CD8(-) double-negative natural killer T cell precursors in the thymus.
Dashtsoodol N, Watarai H, Sakata S, Taniguchi M
PLoS ONE. 2008
PubMed ID: 18997862
Alloreactivity of ex vivo-expanded T cells is correlated with expansion and CD4/CD8 ratio.
Mercier-Letondal P, Montcuquet N, Sauce D, Certoux JM, Jeanningros S, Ferrand C, Bonyhadi M, Tiberghien P, Robinet E
Cytotherapy. 2008
PubMed ID: 18418773
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.
Tzartos JS, Friese MA, Craner MJ, Palace J, Newcombe J, Esiri MM, Fugger L
Am J Pathol. 2008
PubMed ID: 18156204
Gly111Ser mutation in CD8A gene causing CD8 immunodeficiency is found in Spanish Gypsies.
Mancebo E, Moreno-Pelayo MA, Mencía A, de la Calle-Martín O, Allende LM, Sivadorai P, Kalaydjieva L, Bertranpetit J, Coto E, Calleja-Antolín S, Ruiz-Contreras J, Paz-Artal E
Mol Immunol. 2008
PubMed ID: 17658607
CD8+FOXP3+T cells from renal transplant recipients in quiescence induce immunoglobulin-like transcripts-3 and -4 on dendritic cells from their respective donors.
Zhou H, Wang ZD, Zhu X, You Y, Zou P
Transplant Proc. 2007
PubMed ID: 18089323
CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure.
Borchers MT, Wesselkamper SC, Harris NL, Deshmukh H, Beckman E, Vitucci M, Tichelaar JW, Leikauf GD
Exp Mol Pathol. 2007
PubMed ID: 17950725
Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.
Van Laethem F, Sarafova SD, Park JH, Tai X, Pobezinsky L, Guinter TI, Adoro S, Adams A, Sharrow SO, Feigenbaum L, Singer A
Immunity. 2007
PubMed ID: 18023370
Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells.
Klenovsek K, Weisel F, Schneider A, Appelt U, Jonjic S, Messerle M, Bradel-Tretheway B, Winkler TH, Mach M
Blood. 2007
PubMed ID: 17656648
The role of CD8+CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand.
Ben-David H, Sharabi A, Dayan M, Sela M, Mozes E
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17956982
Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia.
Grayson MH, Cheung D, Rohlfing MM, Kitchens R, Spiegel DE, Tucker J, Battaile JT, Alevy Y, Yan L, Agapov E, Kim EY, Holtzman MJ
J Exp Med. 2007
PubMed ID: 17954569
TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production.
Goldszmid RS, Bafica A, Jankovic D, Feng CG, Caspar P, Winkler-Pickett R, Trinchieri G, Sher A
J Exp Med. 2007
PubMed ID: 17923502
T regulatory cells control numbers of NK cells and CD8alpha+ immature dendritic cells in the lymph node paracortex.
Giroux M, Yurchenko E, St-Pierre J, Piccirillo CA, Perreault C
J Immunol. 2007
PubMed ID: 17878345
'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.
Park JH, Adoro S, Lucas PJ, Sarafova SD, Alag AS, Doan LL, Erman B, Liu X, Ellmeier W, Bosselut R, Feigenbaum L, Singer A
Nat Immunol. 2007
PubMed ID: 17873878
Minimal activation of memory CD8+ T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+ T cells.
Belz GT, Bedoui S, Kupresanin F, Carbone FR, Heath WR
Nat Immunol. 2007
PubMed ID: 17767161
T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection.
Bitsaktsis C, Nandi B, Racine R, MacNamara KC, Winslow G
Infect Immun. 2007
PubMed ID: 17664264
Activation of naturally occurring lung CD4(+)CD25(+) regulatory T cells requires CD8 and MHC I interaction.
Joetham A, Takeda K, Miyahara N, Matsubara S, Ohnishi H, Koya T, Dakhama A, Gelfand EW
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17855564
The Foxn1-dependent transcripts PCOLCE2 and mPPP1R16B are not required for normal thymopoiesis.
Heinzel K, Bleul CC
Eur J Immunol. 2007
PubMed ID: 17683113
An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.
Cho JH, Boyman O, Kim HO, Hahm B, Rubinstein MP, Ramsey C, Kim DM, Surh CD, Sprent J
J Exp Med. 2007
PubMed ID: 17664294
Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells.
Sapoznikov A, Fischer JA, Zaft T, Krauthgamer R, Dzionek A, Jung S
J Exp Med. 2007
PubMed ID: 17646404
CD8+ T cells promote inflammation and apoptosis in the liver after sepsis: role of Fas-FasL.
Wesche-Soldato DE, Chung CS, Gregory SH, Salazar-Mather TP, Ayala CA, Ayala A
Am J Pathol. 2007
PubMed ID: 17591956
CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice.
Maeno T, Houghton AM, Quintero PA, Grumelli S, Owen CA, Shapiro SD
J Immunol. 2007
PubMed ID: 17548647
CD8alpha/alpha homodimers fail to function as co-receptor for a CD8-dependent TCR.
McNicol AM, Bendle G, Holler A, Matjeka T, Dalton E, Rettig L, Zamoyska R, Uckert W, Xue SA, Stauss HJ
Eur J Immunol. 2007
PubMed ID: 17506031
Anti-TCR antibody treatment activates a novel population of nonintestinal CD8 alpha alpha+ TCR alpha beta+ regulatory T cells and prevents experimental autoimmune encephalomyelitis.
Tang X, Maricic I, Kumar V
J Immunol. 2007
PubMed ID: 17475828
Gamma interferon responses of CD4 and CD8 T-cell subsets are quantitatively different and independent of each other during pulmonary Mycobacterium bovis BCG infection.
Ngai P, McCormick S, Small C, Zhang X, Zganiacz A, Aoki N, Xing Z
Infect Immun. 2007
PubMed ID: 17307945
FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection.
Wilson TJ, Presti RM, Tassi I, Overton ET, Cella M, Colonna M
Blood. 2007
PubMed ID: 17213291
Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis.
Roberts SJ, Ng BY, Filler RB, Lewis J, Glusac EJ, Hayday AC, Tigelaar RE, Girardi M
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17412837
GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development.
Ling KW, van Hamburg JP, de Bruijn MJ, Kurek D, Dingjan GM, Hendriks RW
Eur J Immunol. 2007
PubMed ID: 17357106
Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice.
Mishra A, Schlotman J, Wang M, Rothenberg ME
J Leukoc Biol. 2007
PubMed ID: 17194734
JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response.
Tao J, Gao Y, Li MO, He W, Chen L, Harvev B, Davis RJ, Flavell RA, Yin Z
Eur J Immunol. 2007
PubMed ID: 17301952
Predominant immature CD8alpha+ dendritic cells prevent graft-vs.-host disease but do not increase the risk of leukemia recurrence.
Xu L, Duan L, Cao K, Yuan G, Peng Y, Huang X, Xiang P, Li S
Eur J Haematol. 2007
PubMed ID: 17253973
Mutating the anchor residues associated with MHC binding inhibits and deviates CD8+ T cell mediated protective immunity against malaria.
Dobaño C, McTague A, Sette A, Hoffman SL, Rogers WO, Doolan DL
Mol Immunol. 2007
PubMed ID: 17169429
Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN.
Hervas-Stubbs S, Rueda P, Lopez L, Leclerc C
J Immunol. 2007
PubMed ID: 17277142
Dendritic cell-T cell interactions: CD8 alpha alpha expressed on dendritic cells regulates T cell proliferation.
Hong L, Webb TJ, Wilkes DS
Immunol Lett. 2007
PubMed ID: 17224189
Exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies.
Burrer R, Buchmeier MJ, Wolfe T, Ting JP, Feuer R, Iglesias A, von Herrath MG
Am J Pathol. 2007
PubMed ID: 17255324
Differential antigen processing by dendritic cell subsets in vivo.
Dudziak D, Kamphorst AO, Heidkamp GF, Buchholz VR, Trumpfheller C, Yamazaki S, Cheong C, Liu K, Lee HW, Park CG, Steinman RM, Nussenzweig MC
Science. 2007
PubMed ID: 17204652
Loss of Bim results in abnormal accumulation of mature CD4-CD8-CD44-CD25- thymocytes.
Hutcheson J, Perlman H
Immunobiology. 2007
PubMed ID: 17869640
CD8 alpha is expressed by human monocytes and enhances Fc gamma R-dependent responses.
Gibbings DJ, Marcet-Palacios M, Sekar Y, Ng MC, Befus AD
BMC Immunol. 2007
PubMed ID: 17678538
Modulation of CD4+ T cell-dependent specific cytotoxic CD8+ T cells differentiation and proliferation by the timing of increase in the pathogen load.
Tzelepis F, Persechini PM, Rodrigues MM
PLoS ONE. 2007
PubMed ID: 17460760
Adoptive transfer of CD8alpha+ dendritic cells (DC) isolated from mice infected with Chlamydia muridarum are more potent in inducing protective immunity than CD8alpha- DC.
Bilenki L, Wang S, Yang J, Fan Y, Jiao L, Joyee AG, Han X, Yang X
J Immunol. 2006
PubMed ID: 17082623
GATA-3 regulates the development and function of invariant NKT cells.
Kim PJ, Pai SY, Brigl M, Besra GS, Gumperz J, Ho IC
J Immunol. 2006
PubMed ID: 17082577
Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.
Erman B, Alag AS, Dahle O, van Laethem F, Sarafova SD, Guinter TI, Sharrow SO, Grinberg A, Love PE, Singer A
J Immunol. 2006
PubMed ID: 17082573
A CD8/Lck transgene is able to drive thymocyte differentiation.
Fragoso RC, Pyarajan S, Irie HY, Burakoff SJ
J Immunol. 2006
PubMed ID: 17056525
During acute Trypanosoma cruzi infection highly susceptible mice deficient in natural killer cells are protected by a single alpha-galactosylceramide treatment.
Duthie MS, Kahn SJ
Immunology. 2006
PubMed ID: 16879622
Genetic determinants of acute inflammation regulate Salmonella infection and modulate Slc11a1 gene (formerly Nramp1) effects in selected mouse lines.
Borrego A, Peters LC, Jensen JR, Ribeiro OG, Koury Cabrera WH, Starobinas N, Seman M, Ibañez OM, De Franco M
Microbes Infect. 2006
PubMed ID: 17035062
Fatal recall responses mediated by CD8 T cells during intracellular bacterial challenge infection.
Bitsaktsis C, Winslow G
J Immunol. 2006
PubMed ID: 16982903
Mapping the binding site on CD8 beta for MHC class I reveals mutants with enhanced binding.
Devine L, Thakral D, Nag S, Dobbins J, Hodsdon ME, Kavathas PB
J Immunol. 2006
PubMed ID: 16951356
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
Marie JC, Liggitt D, Rudensky AY
Immunity. 2006
PubMed ID: 16973387
Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursors.
Ford MS, Zhang ZX, Chen W, Zhang L
J Immunol. 2006
PubMed ID: 16920915
Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes.
Ip CW, Kroner A, Bendszus M, Leder C, Kobsar I, Fischer S, Wiendl H, Nave KA, Martini R
J Neurosci. 2006
PubMed ID: 16885234
Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality.
Yachi PP, Ampudia J, Zal T, Gascoigne NR
Immunity. 2006
PubMed ID: 16872849
CD8 alpha alpha-mediated intraepithelial lymphocyte snatching of thymic leukemia MHC class Ib molecules in vitro and in vivo.
Pardigon N, Takeda K, Saunier B, Hornung F, Gibbs J, Weisberg A, Contractor N, Kelsall B, Bennink JR, Yewdell JW
J Immunol. 2006
PubMed ID: 16849467
Induction of alphadelta- and alphabeta-mediated T cell responses in healthy elderly subjects after influenza vaccination.
Re F, Donnini A, Provinciali M
Biogerontology. 2006
PubMed ID: 16821115
CD8 alpha coreceptor to improve TCR gene transfer to treat melanoma: down-regulation of tumor-specific production of IL-4, IL-5, and IL-10.
Willemsen RA, Sebestyén Z, Ronteltap C, Berrevoets C, Drexhage J, Debets R
J Immunol. 2006
PubMed ID: 16818755
Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells.
Sawa S, Kamimura D, Jin GH, Morikawa H, Kamon H, Nishihara M, Ishihara K, Murakami M, Hirano T
J Exp Med. 2006
PubMed ID: 16717113
Autoreactive T cells mediate NK cell degeneration in autoimmune disease.
Liu R, Van Kaer L, La Cava A, Price M, Campagnolo DI, Collins M, Young DA, Vollmer TL, Shi FD
J Immunol. 2006
PubMed ID: 16621990
Chlamydia infection induces ICOS ligand-expressing and IL-10-producing dendritic cells that can inhibit airway inflammation and mucus overproduction elicited by allergen challenge in BALB/c mice.
Han X, Wang S, Fan Y, Yang J, Jiao L, Qiu H, Yang X
J Immunol. 2006
PubMed ID: 16621988
Crystal structure of the TCR co-receptor CD8alphaalpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution.
Shore DA, Teyton L, Dwek RA, Rudd PM, Wilson IA
J Mol Biol. 2006
PubMed ID: 16530222
Evidence for a functional second thymus in mice.
Terszowski G, Müller SM, Bleul CC, Blum C, Schirmbeck R, Reimann J, Pasquier LD, Amagai T, Boehm T, Rodewald HR
Science. 2006
PubMed ID: 16513945
CD8+ T cells but not polymorphonuclear leukocytes are required to limit chronic oral carriage of Candida albicans in transgenic mice expressing human immunodeficiency virus type 1.
Marquis M, Lewandowski D, Dugas V, Aumont F, Sénéchal S, Jolicoeur P, Hanna Z, de Repentigny L
Infect Immun. 2006
PubMed ID: 16552068
Contribution of NK, NK T, gamma delta T, and alpha beta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi.
Sardinha LR, Elias RM, Mosca T, Bastos KR, Marinho CR, D'Império Lima MR, Alvarez JM
Infect Immun. 2006
PubMed ID: 16552032
Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.
Bilic I, Koesters C, Unger B, Sekimata M, Hertweck A, Maschek R, Wilson CB, Ellmeier W
Nat Immunol. 2006
PubMed ID: 16491076
The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness.
Taube C, Miyahara N, Ott V, Swanson B, Takeda K, Loader J, Shultz LD, Tager AM, Luster AD, Dakhama A, Gelfand EW
J Immunol. 2006
PubMed ID: 16493075
A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity.
Liu M, Chien CC, Burne-Taney M, Molls RR, Racusen LC, Colvin RB, Rabb H
J Am Soc Nephrol. 2006
PubMed ID: 16481417
Differential effect of imipenem treatment on wild-type and NK cell-deficient CD8 knockout mice during acute intra-abdominal injury.
Enoh VT, Fairchild CD, Lin CY, Varma TK, Sherwood ER
Am J Physiol Regul Integr Comp Physiol. 2006
PubMed ID: 16269570
CD8+ T lymphocytes regulate the arteriogenic response to ischemia by infiltrating the site of collateral vessel development and recruiting CD4+ mononuclear cells through the expression of interleukin-16.
Stabile E, Kinnaird T, la Sala A, Hanson SK, Watkins C, Campia U, Shou M, Zbinden S, Fuchs S, Kornfeld H, Epstein SE, Burnett MS
Circulation. 2006
PubMed ID: 16380545
Modelling thymic HIV-1 Nef effects.
Stove V, Verhasselt B
Curr HIV Res. 2006
PubMed ID: 16454711
Molecular, cellular, and antigen requirements for development of age-associated T cell clonal expansions in vivo.
Messaoudi I, Warner J, Nikolich-Zugich D, Fischer M, Nikolich-Zugich J
J Immunol. 2006
PubMed ID: 16365422
SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling.
Evel-Kabler K, Song XT, Aldrich M, Huang XF, Chen SY
J Clin Invest. 2006
PubMed ID: 16357940
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
CD8 T cell-mediated lung damage in response to the extracellular pathogen pneumocystis is dependent on MHC class I expression by radiation-resistant lung cells.
Meissner NN, Lund FE, Han S, Harmsen A
J Immunol. 2005
PubMed ID: 16339567
Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer.
Chang HC, Tan K, Ouyang J, Parisini E, Liu JH, Le Y, Wang X, Reinherz EL, Wang JH
Immunity. 2005
PubMed ID: 16356863
Cell- rather than antibody-mediated immunity leads to the development of profound thrombocytopenia during experimental Plasmodium berghei malaria.
Gramaglia I, Sahlin H, Nolan JP, Frangos JA, Intaglietta M, van der Heyde HC
J Immunol. 2005
PubMed ID: 16301680
H2-M3 major histocompatibility complex class Ib-restricted CD8 T cells induced by Salmonella enterica serovar Typhimurium infection recognize proteins released by Salmonella serovar Typhimurium.
Ugrinovic S, Brooks CG, Robson J, Blacklaws BA, Hormaeche CE, Robinson JH
Infect Immun. 2005
PubMed ID: 16299293
A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development.
Bultman SJ, Gebuhr TC, Magnuson T
Genes Dev. 2005
PubMed ID: 16287714
Antibodies and CD8+ T cells are complementary and essential for natural resistance to a highly lethal cytopathic virus.
Fang M, Sigal LJ
J Immunol. 2005
PubMed ID: 16272340
Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.
Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY
Cell Res. 2005
PubMed ID: 16354571
JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance.
Gao Y, Tao J, Li MO, Zhang D, Chi H, Henegariu O, Kaech SM, Davis RJ, Flavell RA, Yin Z
J Immunol. 2005
PubMed ID: 16237070
Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha.
Chandele A, Kaech SM
J Immunol. 2005
PubMed ID: 16237050
BMP signaling is required for normal thymus development.
Bleul CC, Boehm T
J Immunol. 2005
PubMed ID: 16210626
{gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells.
French JD, Roark CL, Born WK, O'brien RL
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16203967
Recall proliferation potential of memory CD8+ T cells and antiviral protection.
Bachmann MF, Wolint P, Schwarz K, Oxenius A
J Immunol. 2005
PubMed ID: 16177115
Cellular p32 recruits cytomegalovirus kinase pUL97 to redistribute the nuclear lamina.
Marschall M, Marzi A, aus dem Siepen P, Jochmann R, Kalmer M, Auerochs S, Lischka P, Leis M, Stamminger T
J Biol Chem. 2005
PubMed ID: 15975922
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Involvement of fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila.
Kikuchi T, Andarini S, Xin H, Gomi K, Tokue Y, Saijo Y, Honjo T, Watanabe A, Nukiwa T
Infect Immun. 2005
PubMed ID: 16113250
CD8+ T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infection.
Zelinskyy G, Robertson SJ, Schimmer S, Messer RJ, Hasenkrug KJ, Dittmer U
J Virol. 2005
PubMed ID: 16051854
Impaired virus control and severe CD8+ T-cell-mediated immunopathology in chimeric mice deficient in gamma interferon receptor expression on both parenchymal and hematopoietic cells.
Henrichsen P, Bartholdy C, Christensen JP, Thomsen AR
J Virol. 2005
PubMed ID: 16014969
Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse.
Yachi PP, Ampudia J, Gascoigne NR, Zal T
Nat Immunol. 2005
PubMed ID: 15980863
Regulation of follicular dendritic cell networks by activated T cells: the role of CD137 signaling.
Sun Y, Blink SE, Chen JH, Fu YX
J Immunol. 2005
PubMed ID: 16002686
Establishment and characterization of SRIK-NKL: a novel CD8+ natural killer/T cell line derived from a patient with leukemic phase of acute lymphoblastic lymphoma.
Srivastava BI, Srivastava MD
Leuk Res. 2005
PubMed ID: 15927673
CD8alpha-11b+ dendritic cells but not CD8alpha+ dendritic cells mediate cross-tolerance toward intestinal antigens.
Chung Y, Chang JH, Kweon MN, Rennert PD, Kang CY
Blood. 2005
PubMed ID: 15774618
Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression.
Myers L, Croft M, Kwon BS, Mittler RS, Vella AT
J Immunol. 2005
PubMed ID: 15944263
A new dynamic model of CD8+ T effector cell responses via CD4+ T helper-antigen-presenting cells.
Xiang J, Huang H, Liu Y
J Immunol. 2005
PubMed ID: 15944248
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent.
de Visser KE, Korets LV, Coussens LM
Cancer Cell. 2005
PubMed ID: 15894262
CD4+ T cells but Not CD8+ or gammadelta+ lymphocytes are required for host protection against Mycobacterium avium infection and dissemination through the intestinal route.
Petrofsky M, Bermudez LE
Infect Immun. 2005
PubMed ID: 15845464
Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells.
Xin H, Kikuchi T, Andarini S, Ohkouchi S, Suzuki T, Nukiwa T, Huqun, Hagiwara K, Honjo T, Saijo Y
Eur J Immunol. 2005
PubMed ID: 15789339
Leukotriene B4 receptor-1 is essential for allergen-mediated recruitment of CD8+ T cells and airway hyperresponsiveness.
Miyahara N, Takeda K, Miyahara S, Taube C, Joetham A, Koya T, Matsubara S, Dakhama A, Tager AM, Luster AD, Gelfand EW
J Immunol. 2005
PubMed ID: 15814727
Physiological relevance of antigen presentasome (APS), an acquired MHC/costimulatory complex, in the sustained activation of CD4+ T cells in the absence of APCs.
Zhou J, Tagaya Y, Tolouei-Semnani R, Schlom J, Sabzevari H
Blood. 2005
PubMed ID: 15637136
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
Nature. 2005
PubMed ID: 15815621
Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization.
Winkler IG, Hendy J, Coughlin P, Horvath A, Lévesque JP
J Exp Med. 2005
PubMed ID: 15795238
Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule.
Attinger A, Devine L, Wang-Zhu Y, Martin D, Wang JH, Reinherz EL, Kronenberg M, Cheroutre H, Kavathas P
J Immunol. 2005
PubMed ID: 15749886
CD4+CD25+ regulatory T cells control innate immune reactivity after injury.
Murphy TJ, Ni Choileain N, Zang Y, Mannick JA, Lederer JA
J Immunol. 2005
PubMed ID: 15728508
CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.
Antony PA, Piccirillo CA, Akpinarli A, Finkelstein SE, Speiss PJ, Surman DR, Palmer DC, Chan CC, Klebanoff CA, Overwijk WW, Rosenberg SA, Restifo NP
J Immunol. 2005
PubMed ID: 15728465
Immune mediators in a murine model for occupational asthma: studies with toluene diisocyanate.
Matheson JM, Johnson VJ, Luster MI
Toxicol Sci. 2005
PubMed ID: 15590890
The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.
He X, He X, Dave VP, Zhang Y, Hua X, Nicolas E, Xu W, Roe BA, Kappes DJ
Nature. 2005
PubMed ID: 15729333
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.
Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, von Boehmer H, Aifantis I
J Exp Med. 2005
PubMed ID: 15728238
Progressive differentiation and commitment of CD8+ T cells to a poorly cytolytic CD8low phenotype in the presence of IL-4.
Kienzle N, Olver S, Buttigieg K, Groves P, Janas ML, Baz A, Kelso A
J Immunol. 2005
PubMed ID: 15699131
Cross-linking of 4-1BB activates TCR-signaling pathways in CD8+ T lymphocytes.
Nam KO, Kang H, Shin SM, Cho KH, Kwon B, Kwon BS, Kim SJ, Lee HW
J Immunol. 2005
PubMed ID: 15699116
Defective proximal TCR signaling inhibits CD8+ tumor-infiltrating lymphocyte lytic function.
Koneru M, Schaer D, Monu N, Ayala A, Frey AB
J Immunol. 2005
PubMed ID: 15699109
Cutting edge: antibody production to pneumococcal polysaccharides requires CD1 molecules and CD8+ T cells.
Kobrynski LJ, Sousa AO, Nahmias AJ, Lee FK
J Immunol. 2005
PubMed ID: 15699104
Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development.
Feik N, Bilic I, Tinhofer J, Unger B, Littman DR, Ellmeier W
J Immunol. 2005
PubMed ID: 15661911
Peripheral "CD8 tuning" dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo.
Maile R, Siler CA, Kerry SE, Midkiff KE, Collins EJ, Frelinger JA
J Immunol. 2005
PubMed ID: 15634879
Memory CD8 T cells require CD8 coreceptor engagement for calcium mobilization and proliferation, but not cytokine production.
Kerry SE, Maile R, Collins EJ, Frelinger JA
Immunology. 2005
PubMed ID: 15606794
Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice.
Elhage R, Gourdy P, Brouchet L, Jawien J, Fouque MJ, Fiévet C, Huc X, Barreira Y, Couloumiers JC, Arnal JF, Bayard F
Am J Pathol. 2004
PubMed ID: 15579444
Mice depleted of CD8+ T and NK cells are resistant to injury caused by cecal ligation and puncture.
Sherwood ER, Enoh VT, Murphey ED, Lin CY
Lab Invest. 2004
PubMed ID: 15448711
Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient mice.
Bommireddy R, Engle SJ, Ormsby I, Boivin GP, Babcock GF, Doetschman T
Cell Immunol. 2004
PubMed ID: 15922720
Exclusion and inclusion of TCR alpha proteins during T cell development in TCR-transgenic and normal mice.
Lacorazza HD, Nikolich-Zugich J
J Immunol. 2004
PubMed ID: 15494509
Flt3-ligand, IL-4, GM-CSF, and adherence-mediated isolation of murine lung dendritic cells: assessment of isolation technique on phenotype and function.
Swanson KA, Zheng Y, Heidler KM, Zhang ZD, Webb TJ, Wilkes DS
J Immunol. 2004
PubMed ID: 15470028
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor.
Chiang EY, Stroynowski I
J Immunol. 2004
PubMed ID: 15383569
Presence of IFN-gamma does not indicate its necessity for induction of coronary arteritis in an animal model of Kawasaki disease.
Chan WC, Duong TT, Yeung RS
J Immunol. 2004
PubMed ID: 15322214
A novel mutation in CD83 results in the development of a unique population of CD4+ T cells.
García-Martínez LF, Appleby MW, Staehling-Hampton K, Andrews DM, Chen Y, McEuen M, Tang P, Rhinehart RL, Proll S, Paeper B, Brunkow ME, Grandea AG, Howard ED, Walker DE, Charmley P, Jonas M, Shaw S, Latham JA, Ramsdell F
J Immunol. 2004
PubMed ID: 15322158
Deliberate removal of T cell help improves virus-neutralizing antibody production.
Recher M, Lang KS, Hunziker L, Freigang S, Eschli B, Harris NL, Navarini A, Senn BM, Fink K, Lötscher M, Hangartner L, Zellweger R, Hersberger M, Theocharides A, Hengartner H, Zinkernagel RM
Nat Immunol. 2004
PubMed ID: 15300247
CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice.
Lin X, Ma X, Rodriguez M, Roos RP
Int Immunol. 2004
PubMed ID: 15262897
Functional characterization of MHC class II-restricted CD8+CD4- and CD8-CD4- T cell responses to infection in CD4-/- mice.
Pearce EL, Shedlock DJ, Shen H
J Immunol. 2004
PubMed ID: 15294964
CD40 engagement enhances antigen-presenting langerhans cell priming of IFN-gamma-producing CD4+ and CD8+ T cells independently of IL-12.
Gorbachev AV, Fairchild RL
J Immunol. 2004
PubMed ID: 15294958
STAT5 is required for thymopoiesis in a development stage-specific manner.
Kang J, DiBenedetto B, Narayan K, Zhao H, Der SD, Chambers CA
J Immunol. 2004
PubMed ID: 15294943
Role of CD8+ T cells in control of West Nile virus infection.
Shrestha B, Diamond MS
J Virol. 2004
PubMed ID: 15254203
CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development.
McKee AS, Pearce EJ
J Immunol. 2004
PubMed ID: 15240714
Different costimulatory and growth factor requirements for CD4+ and CD8+ T cell-mediated rejection.
Vu MD, Amanullah F, Li Y, Demirci G, Sayegh MH, Li XC
J Immunol. 2004
PubMed ID: 15210777
Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection.
Bitsaktsis C, Huntington J, Winslow G
J Immunol. 2004
PubMed ID: 15153508
Cellular and humoral immunity against vaccinia virus infection of mice.
Xu R, Johnson AJ, Liggitt D, Bevan MJ
J Immunol. 2004
PubMed ID: 15128815
Mechanisms of tolerance induced by transforming growth factor-beta-treated antigen-presenting cells: CD8 regulatory T cells inhibit the effector phase of the immune response in primed mice through a mechanism involving Fas ligand.
Kosiewicz MM, Alard P, Liang S, Clark SL
Int Immunol. 2004
PubMed ID: 15096489
T cell killing does not require the formation of a stable mature immunological synapse.
Purbhoo MA, Irvine DJ, Huppa JB, Davis MM
Nat Immunol. 2004
PubMed ID: 15048111
CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors.
Madakamutil LT, Christen U, Lena CJ, Wang-Zhu Y, Attinger A, Sundarrajan M, Ellmeier W, von Herrath MG, Jensen P, Littman DR, Cheroutre H
Science. 2004
PubMed ID: 15105501
TOX provides a link between calcineurin activation and CD8 lineage commitment.
Aliahmad P, O'Flaherty E, Han P, Goularte OD, Wilkinson B, Satake M, Molkentin JD, Kaye J
J Exp Med. 2004
PubMed ID: 15078895
Differential requirement for the CD40-CD154 costimulatory pathway during Th cell priming by CD8 alpha+ and CD8 alpha- murine dendritic cell subsets.
Yasumi T, Katamura K, Yoshioka T, Meguro TA, Nishikomori R, Heike T, Inobe M, Kon S, Uede T, Nakahata T
J Immunol. 2004
PubMed ID: 15067060
Enhanced tumor responses to dendritic cells in the absence of CD8-positive cells.
Ribas A, Wargo JA, Comin-Anduix B, Sanetti S, Schumacher LY, McLean C, Dissette VB, Glaspy JA, McBride WH, Butterfield LH, Economou JS
J Immunol. 2004
PubMed ID: 15067052
Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer.
Seaman MN
J Cell Biol. 2004
PubMed ID: 15078902
Mechanisms of tolerance induced by TGF beta-treated APC: CD4 regulatory T cells prevent the induction of the immune response possibly through a mechanism involving TGF beta.
Alard P, Clark SL, Kosiewicz MM
Eur J Immunol. 2004
PubMed ID: 15048712
Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T cell subsets may contribute differently to the pathogenesis.
Chen Z, Yu S, Concha HQ, Zhu Y, Mix E, Winblad B, Ljunggren HG, Zhu J
Brain Behav Immun. 2004
PubMed ID: 14759595
Contribution of antigen-primed CD8+ T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13.
Miyahara N, Takeda K, Kodama T, Joetham A, Taube C, Park JW, Miyahara S, Balhorn A, Dakhama A, Gelfand EW
J Immunol. 2004
PubMed ID: 14764728
Liver dendritic cells present bacterial antigens and produce cytokines upon Salmonella encounter.
Johansson C, Wick MJ
J Immunol. 2004
PubMed ID: 14764722
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen.
Bry L, Brenner MB
J Immunol. 2004
PubMed ID: 14688352
Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement.
Kerry SE, Buslepp J, Cramer LA, Maile R, Hensley LL, Nielsen AI, Kavathas P, Vilen BJ, Collins EJ, Frelinger JA
J Immunol. 2003
PubMed ID: 14568922
Regulation of alternative splicing by SRrp86 and its interacting proteins.
Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG
Mol Cell Biol. 2003
PubMed ID: 14559993
Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection.
Ehst BD, Ingulli E, Jenkins MK
Am J Transplant. 2003
PubMed ID: 14525595
Regulatory functions of CD8+CD28- T cells in an autoimmune disease model.
Najafian N, Chitnis T, Salama AD, Zhu B, Benou C, Yuan X, Clarkson MR, Sayegh MH, Khoury SJ
J Clin Invest. 2003
PubMed ID: 14523041
Morpholino antisense oligonucleotide-mediated gene knockdown during thymocyte development reveals role for Runx3 transcription factor in CD4 silencing during development of CD4-/CD8+ thymocytes.
Ehlers M, Laule-Kilian K, Petter M, Aldrian CJ, Grueter B, Würch A, Yoshida N, Watanabe T, Satake M, Steimle V
J Immunol. 2003
PubMed ID: 14500656
CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection.
Serpe CJ, Coers S, Sanders VM, Jones KJ
Brain Behav Immun. 2003
PubMed ID: 12946661
A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.
Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ
Science. 2003
PubMed ID: 14500983
Cutting Edge: Multiple autoimmune pathways in kd/kd mice.
Hancock WW, Tsai TL, Madaio MP, Gasser DL
J Immunol. 2003
PubMed ID: 12960297
Sequence variability analysis of human class I and class II MHC molecules: functional and structural correlates of amino acid polymorphisms.
Reche PA, Reinherz EL
J Mol Biol. 2003
PubMed ID: 12899833
Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo.
Matsuzaki J, Tsuji T, Chamoto K, Takeshima T, Sendo F, Nishimura T
Cell Immunol. 2003
PubMed ID: 14609575
Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells.
Bosselut R, Guinter TI, Sharrow SO, Singer A
J Exp Med. 2003
PubMed ID: 12810689
Beta 2 microglobulin knockout mice are resistant to lethal intraabdominal sepsis.
Sherwood ER, Lin CY, Tao W, Hartmann CA, Dujon JE, French AJ, Varma TK
Am J Respir Crit Care Med. 2003
PubMed ID: 12626348
Immune enhancement of skin carcinogenesis by CD4+ T cells.
Daniel D, Meyer-Morse N, Bergsland EK, Dehne K, Coussens LM, Hanahan D
J Exp Med. 2003
PubMed ID: 12695493
CD8+ T cells accumulate in the lungs of Mycobacterium tuberculosis-infected Kb-/-Db-/- mice, but provide minimal protection.
Urdahl KB, Liggitt D, Bevan MJ
J Immunol. 2003
PubMed ID: 12574368
ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro.
Tsujimura H, Tamura T, Gongora C, Aliberti J, Reis e Sousa C, Sher A, Ozato K
Blood. 2003
PubMed ID: 12393459
CD3 delta establishes a functional link between the T cell receptor and CD8.
Doucey MA, Goffin L, Naeher D, Michielin O, Baumgärtner P, Guillaume P, Palmer E, Luescher IF
J Biol Chem. 2003
PubMed ID: 12215456
Soluble HLA-A,-B,-C and -G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation.
Contini P, Ghio M, Poggi A, Filaci G, Indiveri F, Ferrone S, Puppo F
Eur J Immunol. 2003
PubMed ID: 12594841
Superantigenic activity is responsible for induction of coronary arteritis in mice: an animal model of Kawasaki disease.
Duong TT, Silverman ED, Bissessar MV, Yeung RS
Int Immunol. 2003
PubMed ID: 12502728
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
The CD8alpha gene locus is regulated by the Ikaros family of proteins.
Harker N, Naito T, Cortes M, Hostert A, Hirschberg S, Tolaini M, Roderick K, Georgopoulos K, Kioussis D
Mol Cell. 2002
PubMed ID: 12504015
Increased hepatic iron in mice lacking classical MHC class I molecules.
Cardoso EM, Macedo MG, Rohrlich P, Ribeiro E, Silva MT, Lemonnier FA, de Sousa M
Blood. 2002
PubMed ID: 12393413
A unique mechanism for innate cytokine promotion of T cell responses to viral infections.
Pien GC, Nguyen KB, Malmgaard L, Satoskar AR, Biron CA
J Immunol. 2002
PubMed ID: 12421964
Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity.
Cawthon AG, Alexander-Miller MA
J Immunol. 2002
PubMed ID: 12244138
The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.
Saito M, Ishikawa F
J Biol Chem. 2002
PubMed ID: 12124384
CD4 and CD8 T cells, but not B cells, are critical to the control of murine experimental autoimmune neuritis.
Zhu Y, Bao L, Zhu S, Chen Z, van der Meide P, Nennesmo I, Winblad B, Ljunggren HG, Zhu J
Exp Neurol. 2002
PubMed ID: 12429233
MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses.
VanLith ML, Kohlgraf KG, Sivinski CL, Tempero RM, Hollingsworth MA
Int Immunol. 2002
PubMed ID: 12147624
Identification of CD8alpha+CD11c- lineage phenotype-negative cells in the spleen as committed precursor of CD8alpha+ dendritic cells.
Wang Y, Zhang Y, Yoneyama H, Onai N, Sato T, Matsushima K
Blood. 2002
PubMed ID: 12091350
Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential.
Martín P, Del Hoyo GM, Anjuère F, Arias CF, Vargas HH, Fernández-L A, Parrillas V, Ardavín C
Blood. 2002
PubMed ID: 12091326
Novel CD8+ T cell antagonists based on beta 2-microglobulin.
Glick M, Price DA, Vuidepot AL, Andersen TB, Hutchinson SL, Laugel B, Sewell AK, Boulter JM, Dunbar PR, Cerundolo V, Oxenius A, Bell JI, Richards WG, Jakobsen BK
J Biol Chem. 2002
PubMed ID: 11914379
The variable, C(H)1, C(H)2 and C(H)3 domains of Ig heavy chain are dispensable for pre-BCR function in transgenic mice.
Muljo SA, Schlissel MS
Int Immunol. 2002
PubMed ID: 12039909
CD4 and CD8 T cells in susceptibility/protection to collagen-induced arthritis in HLA-DQ8-transgenic mice: implications for rheumatoid arthritis.
Taneja V, Taneja N, Paisansinsup T, Behrens M, Griffiths M, Luthra H, David CS
J Immunol. 2002
PubMed ID: 12023391
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD
Science. 2002
PubMed ID: 12040188
Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences.
Garefalaki A, Coles M, Hirschberg S, Mavria G, Norton T, Hostert A, Kioussis D
Immunity. 2002
PubMed ID: 12049716
Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression.
Ellmeier W, Sunshine MJ, Maschek R, Littman DR
Immunity. 2002
PubMed ID: 12049715
CD8 alpha-deficient mice are highly susceptible to 5-fluorouracil-induced lethality.
Itoh N, Nishimura H, Matsuguchi T, Yajima T, Mokuno Y, Hiromatsu T, Nimura Y, Yoshikai Y
Clin Diagn Lab Immunol. 2002
PubMed ID: 11986258
CD4(+) T cell-dependent airway mucus production occurs in response to IL-5 expression in lung.
Justice JP, Crosby J, Borchers MT, Tomkinson A, Lee JJ, Lee NA
Am J Physiol Lung Cell Mol Physiol. 2002
PubMed ID: 11943672
CD8(+) T cells are not necessary for 1 alpha,25-dihydroxyvitamin D(3) to suppress experimental autoimmune encephalomyelitis in mice.
Meehan TF, DeLuca HF
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11929984
CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major.
Belkaid Y, Von Stebut E, Mendez S, Lira R, Caler E, Bertholet S, Udey MC, Sacks D
J Immunol. 2002
PubMed ID: 11937556
Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3.
Kieffer LJ, Greally JM, Landres I, Nag S, Nakajima Y, Kohwi-Shigematsu T, Kavathas PB
J Immunol. 2002
PubMed ID: 11937547
The complementarity-determining region-like loops of CD8 alpha interact differently with beta 2-microglobulin of the class I molecules H-2Kb and thymic leukemia antigen, while similarly with their alpha 3 domains.
Devine L, Rogozinski L, Naidenko OV, Cheroutre H, Kavathas PB
J Immunol. 2002
PubMed ID: 11937542
Ectopic expression of IL-5 identifies an additional CD4(+) T cell mechanism of airway eosinophil recruitment.
Crosby JR, Shen HH, Borchers MT, Justice JP, Ansay T, Lee JJ, Lee NA
Am J Physiol Lung Cell Mol Physiol. 2002
PubMed ID: 11741821
CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation.
Daniels MA, Devine L, Miller JD, Moser JM, Lukacher AE, Altman JD, Kavathas P, Hogquist KA, Jameson SC
Immunity. 2001
PubMed ID: 11754824
T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL.
Leishman AJ, Naidenko OV, Attinger A, Koning F, Lena CJ, Xiong Y, Chang HC, Reinherz E, Kronenberg M, Cheroutre H
Science. 2001
PubMed ID: 11729321
Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding.
Moody AM, Chui D, Reche PA, Priatel JJ, Marth JD, Reinherz EL
Cell. 2001
PubMed ID: 11719190
Regulation of CD8 expression in mast cells by exogenous or endogenous nitric oxide.
Nohara O, Kulka M, Déry RE, Wills FL, Hirji NS, Gilchrist M, Befus AD
J Immunol. 2001
PubMed ID: 11698471
Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure.
Burne MJ, Daniels F, El Ghandour A, Mauiyyedi S, Colvin RB, O'Donnell MP, Rabb H
J Clin Invest. 2001
PubMed ID: 11696572
CD8 expression up to the double-positive CD3(low/intermediate) stage of thymic differentiation is sufficient for development of peripheral functional cytotoxic T lymphocytes.
Zhang XL, Zhao S, Borenstein SH, Liu Y, Jayabalasingham B, Chamberlain JW
J Exp Med. 2001
PubMed ID: 11535636
A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice.
Poltorak A, Merlin T, Nielsen PJ, Sandra O, Smirnova I, Schupp I, Boehm T, Galanos C, Freudenberg MA
J Immunol. 2001
PubMed ID: 11489994
The carboxyl-terminal valine is required for transport of glycoprotein CD8 alpha from the endoplasmic reticulum to the intermediate compartment.
Iodice L, Sarnataro S, Bonatti S
J Biol Chem. 2001
PubMed ID: 11384990
Identification of quantitative trait loci controlling activation of TRBV4 CD8+ T cells during murine gamma-herpesvirus-induced infectious mononucleosis.
Hardy CL, Lu L, Nguyen P, Woodland DL, Williams RW, Blackman MA
Immunogenetics. 2001
PubMed ID: 11486276
Influence of CD4 or CD8 deficiency on collagen-induced arthritis.
Ehinger M, Vestberg M, Johansson AC, Johannesson M, Svensson A, Holmdahl R
Immunology. 2001
PubMed ID: 11454058
Familial CD8 deficiency due to a mutation in the CD8 alpha gene.
de la Calle-Martin O, Hernandez M, Ordi J, Casamitjana N, Arostegui JI, Caragol I, Ferrando M, Labrador M, Rodriguez-Sanchez JL, Espanol T
J Clin Invest. 2001
PubMed ID: 11435463
Gamma delta T cell-deficient mice have a down-regulated CD8+ T cell immune response against Encephalitozoon cuniculi infection.
Moretto M, Durell B, Schwartzman JD, Khan IA
J Immunol. 2001
PubMed ID: 11390490
CD8alpha(-) and CD8alpha(+) subclasses of dendritic cells undergo phenotypic and functional maturation in vitro and in vivo.
De Smedt T, Butz E, Smith J, Maldonado-López R, Pajak B, Moser M, Maliszewski C
J Leukoc Biol. 2001
PubMed ID: 11404381
CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway.
Guo Z, Meng L, Kim O, Wang J, Hart J, He G, Alegre ML, Thistlethwaite JR, Pearson TC, Larsen CP, Newell KA
Transplantation. 2001
PubMed ID: 11403253
Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes.
Bosselut R, Feigenbaum L, Sharrow SO, Singer A
Immunity. 2001
PubMed ID: 11336693
Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.
Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH
J Biol Chem. 2001
PubMed ID: 11102443
Modulation of CD8 and CD3 by HIV or HIV antigens.
Jason J, Inge KL
Scand J Immunol. 2001
PubMed ID: 11251883
The sequence of the human genome.
Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigó R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X
Science. 2001
PubMed ID: 11181995
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Impairment of CD4(+) T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants.
Ciurea A, Hunziker L, Klenerman P, Hengartner H, Zinkernagel RM
J Exp Med. 2001
PubMed ID: 11157050
Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4, KO, and CD8 KO mice.
Bumgardner GL, Gao D, Li J, Baskin JH, Heininger M, Orosz CG
Transplantation. 2000
PubMed ID: 11152110
CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplants.
Fischbein MP, Ardehali A, Yun J, Schoenberger S, Laks H, Irie Y, Dempsey P, Cheng G, Fishbein MC, Bonavida B
J Immunol. 2000
PubMed ID: 11120867
IL-12-activated NK cells reduce lung eosinophilia to the attachment protein of respiratory syncytial virus but do not enhance the severity of illness in CD8 T cell-immunodeficient conditions.
Hussell T, Openshaw PJ
J Immunol. 2000
PubMed ID: 11120841
CD4+ Th1 and CD8+ type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity.
Wang B, Fujisawa H, Zhuang L, Freed I, Howell BG, Shahid S, Shivji GM, Mak TW, Sauder DN
J Immunol. 2000
PubMed ID: 11120799
A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.
Comings DE, Gade-Andavolu R, Gonzalez N, Wu S, Muhleman D, Blake H, Mann MB, Dietz G, Saucier G, MacMurray JP
Clin Genet. 2000
PubMed ID: 11140838
Calyculin A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells.
Allam A, Illges H
Immunobiology. 2000
PubMed ID: 11131152
CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling.
Hida S, Ogasawara K, Sato K, Abe M, Takayanagi H, Yokochi T, Sato T, Hirose S, Shirai T, Taki S, Taniguchi T
Immunity. 2000
PubMed ID: 11114377
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Dendritic cells prime in vivo alloreactive CD4 T lymphocytes toward type 2 cytokine- and TGF-beta-producing cells in the absence of CD8 T cell activation.
Foucras G, Coudert JD, Coureau C, Guéry JC
J Immunol. 2000
PubMed ID: 11046027
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
The role of cytotoxic T lymphocytes in corneal allograft rejection.
Hegde S, Niederkorn JY
Invest Ophthalmol Vis Sci. 2000
PubMed ID: 11006223
Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in mice.
Rabb H, Daniels F, O'Donnell M, Haq M, Saba SR, Keane W, Tang WW
Am J Physiol Renal Physiol. 2000
PubMed ID: 10966932
CD8+ T cells are necessary for recognition of allelic, but not locus-mismatched or xeno-, HLA class I transplantation antigens.
Borenstein SH, Graham J, Zhang XL, Chamberlain JW
J Immunol. 2000
PubMed ID: 10946256
Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera.
Wang CC, Biben C, Robb L, Nassir F, Barnett L, Davidson NO, Koentgen F, Tarlinton D, Harvey RP
Dev Biol. 2000
PubMed ID: 10926756
A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung.
D'Souza CD, Cooper AM, Frank AA, Ehlers S, Turner J, Bendelac A, Orme IM
Am J Respir Cell Mol Biol. 2000
PubMed ID: 10919985
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.
Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M
Cell. 2000
PubMed ID: 10943842
The role of CD8(+) T cells and major histocompatibility complex class I expression in the central nervous system of mice infected with neurovirulent Sindbis virus.
Kimura T, Griffin DE
J Virol. 2000
PubMed ID: 10846095
Cutting edge: soluble HLA-G1 triggers CD95/CD95 ligand-mediated apoptosis in activated CD8+ cells by interacting with CD8.
Fournel S, Aguerre-Girr M, Huc X, Lenfant F, Alam A, Toubert A, Bensussan A, Le Bouteiller P
J Immunol. 2000
PubMed ID: 10843658
Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha.
Gao GF, Willcox BE, Wyer JR, Boulter JM, O'Callaghan CA, Maenaka K, Stuart DI, Jones EY, Van Der Merwe PA, Bell JI, Jakobsen BK
J Biol Chem. 2000
PubMed ID: 10809759
Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus.
Bosselut R, Kubo S, Guinter T, Kopacz JL, Altman JD, Feigenbaum L, Singer A
Immunity. 2000
PubMed ID: 10795739
The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease.
Liu P, Aitken K, Kong YY, Opavsky MA, Martino T, Dawood F, Wen WH, Kozieradzki I, Bachmaier K, Straus D, Mak TW, Penninger JM
Nat Med. 2000
PubMed ID: 10742150
Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice.
Kennedy MK, Glaccum M, Brown SN, Butz EA, Viney JL, Embers M, Matsuki N, Charrier K, Sedger L, Willis CR, Brasel K, Morrissey PJ, Stocking K, Schuh JC, Joyce S, Peschon JJ
J Exp Med. 2000
PubMed ID: 10704459
Beta 2-microglobulin/CD8 -/- mice reveal significant role for CD8+ T cells in graft rejection responses in beta 2-microglobulin -/- mice.
Freland S, Ljunggren HG
Scand J Immunol. 2000
PubMed ID: 10736089
PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells.
Guerriero A, Langmuir PB, Spain LM, Scott EW
Blood. 2000
PubMed ID: 10648399
Human CD8 beta, but not mouse CD8 beta, can be expressed in the absence of CD8 alpha as a beta beta homodimer.
Devine L, Kieffer LJ, Aitken V, Kavathas PB
J Immunol. 2000
PubMed ID: 10623829
Differential gene expression in CD3epsilon- and RAG1-deficient thymuses: definition of a set of genes potentially involved in thymocyte maturation.
Carrier A, Nguyen C, Victorero G, Granjeaud S, Rocha D, Bernard K, Miazek A, Ferrier P, Malissen M, Naquet P, Malissen B, Jordan BR
Immunogenetics. 1999
PubMed ID: 10630289
Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction.
Bosselut R, Zhang W, Ashe JM, Kopacz JL, Samelson LE, Singer A
J Exp Med. 1999
PubMed ID: 10562325
The role of CD8 alpha' in the CD4 versus CD8 lineage choice.
Salmon P, Mong M, Kang XJ, Cado D, Robey E
J Immunol. 1999
PubMed ID: 10553054
Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1.
Pace KE, Lee C, Stewart PL, Baum LG
J Immunol. 1999
PubMed ID: 10490978
Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection.
Opavsky MA, Penninger J, Aitken K, Wen WH, Dawood F, Mak T, Liu P
Circ Res. 1999
PubMed ID: 10488058
Differential control of autoantibodies and lymphoproliferation by Fas ligand expression on CD4+ and CD8+ T cells in vivo.
Maldonado MA, MacDonald GC, Kakkanaiah VN, Fecho K, Dransfield M, Sekiguchi D, Cohen PL, Eisenberg RA
J Immunol. 1999
PubMed ID: 10477580
A quantitative genetic analysis of slow-wave sleep in influenza-infected CXB recombinant inbred mice.
Toth LA, Williams RW
Behav Genet. 1999
PubMed ID: 10765562
Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells.
Newell KA, He G, Guo Z, Kim O, Szot GL, Rulifson I, Zhou P, Hart J, Thistlethwaite JR, Bluestone JA
J Immunol. 1999
PubMed ID: 10452966
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D
Genes Dev. 1999
PubMed ID: 10444591
Differing MHC class I requirements for induction and propagation of experimental systemic lupus erythematosus.
Singer DS, Zinger H, Kohn LD, Mozes E
Eur J Immunol. 1999
PubMed ID: 10427989
An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals.
Tilloy F, Treiner E, Park SH, Garcia C, Lemonnier F, de la Salle H, Bendelac A, Bonneville M, Lantz O
J Exp Med. 1999
PubMed ID: 10377186
CD8+ CTLs are essential for protective immunity against Encephalitozoon cuniculi infection.
Khan IA, Schwartzman JD, Kasper LH, Moretto M
J Immunol. 1999
PubMed ID: 10229850
Mechanisms of nasal tolerance induction in experimental autoimmune myasthenia gravis: identification of regulatory cells.
Shi FD, Li H, Wang H, Bai X, van der Meide PH, Link H, Ljunggren HG
J Immunol. 1999
PubMed ID: 10229808
Corynebacterium parvum- and Mycobacterium bovis Bacillus Calmette and Guerin-induced granuloma formation in mice lacking CD4 and CD8.
Senaldi G, Shaklee CL, Mak TW, Ulich TR
Cell Immunol. 1999
PubMed ID: 10222057
Generation and function of bone marrow-derived dendritic cells from CD4/CD8(-/-) double-knockout mice.
Corsi MM, Sandberg JK, Wasserman K, Maes HH, Kiessling R
Immunol Lett. 1999
PubMed ID: 10369133
Generation of humanized mice susceptible to peptide-induced inflammatory heart disease.
Bachmaier K, Neu N, Yeung RS, Mak TW, Liu P, Penninger JM
Circulation. 1999
PubMed ID: 10199887
Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts.
Nakatsuji T
Tohoku J Exp Med. 1999
PubMed ID: 10458478
Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice.
Rottenberg ME, Gigliotti Rothfuchs AC, Gigliotti D, Svanholm C, Bandholtz L, Wigzell H
J Immunol. 1999
PubMed ID: 10072530
The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation.
Petersen-Mahrt SK, Estmer C, Ohrmalm C, Matthews DA, Russell WC, Akusjärvi G
EMBO J. 1999
PubMed ID: 10022843
The CD8beta ectodomain contributes to the augmented coreceptor function of CD8alphabeta heterodimers relative to CD8alphaalpha homodimers.
Witte T, Spoerl R, Chang HC
Cell Immunol. 1999
PubMed ID: 9973530
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells.
Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Deursen J, Sangster MY, Bunting KD, Grosveld GC, Ihle JN
Immunity. 1999
PubMed ID: 10072077
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
The central role of CD4(+) T cells in the antitumor immune response.
Hung K, Hayashi R, Lafond-Walker A, Lowenstein C, Pardoll D, Levitsky H
J Exp Med. 1998
PubMed ID: 9858522
Beta 2-microglobulin knockout mice are highly susceptible to polyoma virus tumorigenesis.
Drake DR, Lukacher AE
Virology. 1998
PubMed ID: 9875336
Zinc is essential for binding of p56(lck) to CD4 and CD8alpha.
Lin RS, Rodriguez C, Veillette A, Lodish HF
J Biol Chem. 1998
PubMed ID: 9830036
Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1.
Mulder GB, Manley N, Maggio-Price L
Teratology. 1998
PubMed ID: 9894676
Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.
Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL
Nature. 1998
PubMed ID: 9804427
The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.
Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D
Cell. 1998
PubMed ID: 9790534
Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb.
Kern PS, Teng MK, Smolyar A, Liu JH, Liu J, Hussey RE, Spoerl R, Chang HC, Reinherz EL, Wang JH
Immunity. 1998
PubMed ID: 9806638
Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells.
Hostert A, Garefalaki A, Mavria G, Tolaini M, Roderick K, Norton T, Mee PJ, Tybulewicz VL, Coles M, Kioussis D
Immunity. 1998
PubMed ID: 9806636
Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells.
Ellmeier W, Sunshine MJ, Losos K, Littman DR
Immunity. 1998
PubMed ID: 9806635
Thymic heterotypic cellular complexes in gene-targeted mice with defined blocks in T cell development and adhesion molecule expression.
Oliveira-dos-Santos AJ, Penninger JM, Rieker-Geley T, Matsumoto G, Mak TM, Wick G
Eur J Immunol. 1998
PubMed ID: 9754575
CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis.
Murray PD, Pavelko KD, Leibowitz J, Lin X, Rodriguez M
J Virol. 1998
PubMed ID: 9696828
Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice.
Huber M, Timms E, Mak TW, Röllinghoff M, Lohoff M
Infect Immun. 1998
PubMed ID: 9673288
Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production.
Kanakaraj P, Schafer PH, Cavender DE, Wu Y, Ngo K, Grealish PF, Wadsworth SA, Peterson PA, Siekierka JJ, Harris CA, Fung-Leung WP
J Exp Med. 1998
PubMed ID: 9625767
Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity.
Lin X, Pease LR, Murray PD, Rodriguez M
J Immunol. 1998
PubMed ID: 9605173
Requirement of the CD8+ or CD4+ T lymphocyte subsets for the rejection of lymphoma and fibrosarcoma grafts studied in gene knockout hosts.
Wen T, Trümper L, Fung-Leung W, Rahemtulla A, Klein E, Klein G, Mak TW
Immunol Lett. 1998
PubMed ID: 9657273
Lack of local suppression in orally tolerant CD8-deficient mice reveals a critical regulatory role of CD8+ T cells in the normal gut mucosa.
Grdic D, Hörnquist E, Kjerrulf M, Lycke NY
J Immunol. 1998
PubMed ID: 9551910
A crucial role for B cells in neuroinvasive scrapie.
Klein MA, Frigg R, Flechsig E, Raeber AJ, Kalinke U, Bluethmann H, Bootz F, Suter M, Zinkernagel RM, Aguzzi A
Nature. 1997
PubMed ID: 9414161
Comparison of the roles of CD8 alpha alpha and CD8 alpha beta in interaction with MHC class I.
Sun J, Kavathas PB
J Immunol. 1997
PubMed ID: 9550407
Interactions of HLA-B*4801 with peptide and CD8.
Martinez-Naves E, Barber LD, Madrigal JA, Vullo CM, Clayberger C, Lyu SC, Williams RC, Gorodezky C, Markow T, Petzl-Erler ML, Parham P
Tissue Antigens. 1997
PubMed ID: 9331948
The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes.
Penninger JM, Sirard C, Mittrücker HW, Chidgey A, Kozieradzki I, Nghiem M, Hakem A, Kimura T, Timms E, Boyd R, Taniguchi T, Matsuyama T, Mak TW
Immunity. 1997
PubMed ID: 9285409
Interaction of the nuclear matrix-associated region (MAR)-binding proteins, SATB1 and CDP/Cux, with a MAR element (L2a) in an upstream regulatory region of the mouse CD8a gene.
Banan M, Rojas IC, Lee WH, King HL, Harriss JV, Kobayashi R, Webb CF, Gottlieb PD
J Biol Chem. 1997
PubMed ID: 9218488
Differential requirements for survival and proliferation of CD8 naïve or memory T cells.
Tanchot C, Lemonnier FA, Pérarnau B, Freitas AA, Rocha B
Science. 1997
PubMed ID: 9197272
Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2.
Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI, Bell JI, Jones EY, Jakobsen BK
Nature. 1997
PubMed ID: 9177355
A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development.
Wiest DL, Ashe JM, Howcroft TK, Lee HM, Kemper DM, Negishi I, Singer DS, Singer A, Abe R
Immunity. 1997
PubMed ID: 9208839
A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice.
Hostert A, Tolaini M, Festenstein R, McNeill L, Malissen B, Williams O, Zamoyska R, Kioussis D
J Immunol. 1997
PubMed ID: 9126989
Impairment of T cell development in deltaEF1 mutant mice.
Higashi Y, Moribe H, Takagi T, Sekido R, Kawakami K, Kikutani H, Kondoh H
J Exp Med. 1997
PubMed ID: 9126927
Decreased tumor surveillance in perforin-deficient mice.
van den Broek ME, Kägi D, Ossendorp F, Toes R, Vamvakas S, Lutz WK, Melief CJ, Zinkernagel RM, Hengartner H
J Exp Med. 1996
PubMed ID: 8920866
The natural history of disease expression in CD4 and CD8 gene-deleted New Zealand black (NZB) mice.
Chen SY, Takeoka Y, Ansari AA, Boyd R, Klinman DM, Gershwin ME
J Immunol. 1996
PubMed ID: 8805673
Control of MHC restriction by TCR Valpha CDR1 and CDR2.
Sim BC, Zerva L, Greene MI, Gascoigne NR
Science. 1996
PubMed ID: 8688082
Both CD4+ and CD8+ T cells are essential to induce experimental autoimmune myasthenia gravis.
Zhang GX, Xiao BG, Bakhiet M, van der Meide P, Wigzell H, Link H, Olsson T
J Exp Med. 1996
PubMed ID: 8760788
Polyoma tumor development in neonatally polyoma-virus-infected CD4-/- and CD8-/- single knockout and CD4-/-8-/- double knockout mice.
Berke Z, Wen T, Klein G, Dalianis T
Int J Cancer. 1996
PubMed ID: 8707416
Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.
Bouvier G, Watrin F, Naspetti M, Verthuy C, Naquet P, Ferrier P
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8755570
Mapping new murine polymorphisms detected by random amplified polymorphic DNA (RAPD) PCR.
Cheah Y, Paigen B
Mamm Genome. 1996
PubMed ID: 8672138
Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes.
Li T, Ramirez K, Palacios R
Cell Growth Differ. 1996
PubMed ID: 8788039
Chromosomal localization of the genes encoding rat CD4, CD8alpha, and CD8beta.
Dissen E, Fossum S
Immunogenetics. 1996
PubMed ID: 8753864
Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.
Spur NK, Bashir R, Bushby K, Cox A, Cox S, Hilde Brandt F, Hill N, Kao FT, Krols L, Marzella R, Miller N, Nothwang HG, Rocchi M, Sarfarazi M, Stratakis CA, Wallgren-Petterson C, Naylor S
Cytogenet Cell Genet. 1996
PubMed ID: 8751373
CD4-negative cytotoxic T cells with a T cell receptor alpha/beta intermediate expression in CD8-deficient mice.
Dalloul AH, Ngo K, Fung-Leung WP
Eur J Immunol. 1996
PubMed ID: 8566069
The SMXA: a new set of recombinant inbred strain of mice consisting of 26 substrains and their genetic profile.
Nishimura M, Hirayama N, Serikawa T, Kanehira K, Matsushima Y, Katoh H, Wakana S, Kojima A, Hiai H
Mamm Genome. 1995
PubMed ID: 8747923
T cell development in CD8-/- mice. Thymic positive selection is biased toward the helper phenotype.
Bachmann MF, Oxenius A, Mak TW, Zinkernagel RM
J Immunol. 1995
PubMed ID: 7561076
An anchored molecular map of mouse chromosome 6 with an analysis of interference.
Davies PO, Melanitou E, Asano M, Avner PR, Montagutelli X
Mamm Genome. 1995
PubMed ID: 8563173
Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin-specific protective immunity despite normal gut mucosal IgA differentiation.
Hörnquist CE, Ekman L, Grdic KD, Schön K, Lycke NY
J Immunol. 1995
PubMed ID: 7673704
Polyomavirus persists in CD4/8 double-knockout, but not in CD4 or CD8 single-knockout mice.
Berke Z, Wen T, Jin S, Klein G, Dalianis T
Virology. 1995
PubMed ID: 7676644
Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis.
Simpson SJ, Mizoguchi E, Allen D, Bhan AK, Terhorst C
Eur J Immunol. 1995
PubMed ID: 7589135
Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells.
Koh DR, Ho A, Rahemtulla A, Fung-Leung WP, Griesser H, Mak TW
Eur J Immunol. 1995
PubMed ID: 7589126
Outcome of infection with different strains of Trypanosoma cruzi in mice lacking CD4 and/or CD8.
Rottenberg ME, Riarte A, Sporrong L, Altcheh J, Petray P, Ruiz AM, Wigzell H, Orn A
Immunol Lett. 1995
PubMed ID: 7622189
Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.
Fung-Leung WP, Kündig TM, Ngo K, Panakos J, De Sousa-Hitzler J, Wang E, Ohashi PS, Mak TW, Lau CY
J Exp Med. 1994
PubMed ID: 8064243
Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line.
Hara T, Harada N, Mitsui H, Miura T, Ishizaka T, Miyajima A
Blood. 1994
PubMed ID: 8018917
A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice.
Wallace VA, Kondo S, Kono T, Xing Z, Timms E, Furlonger C, Keystone E, Gauldie J, Sauder DN, Mak TW
Eur J Immunol. 1994
PubMed ID: 7911425
Endogenous nonecotropic proviruses mapped with oligonucleotide probes from the long terminal repeat region.
Frankel WN, Coffin JM
Mamm Genome. 1994
PubMed ID: 8075500
The role of charge and multiple faces of the CD8 alpha/alpha homodimer in binding to major histocompatibility complex class I molecules: support for a bivalent model.
Giblin PA, Leahy DJ, Mennone J, Kavathas PB
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8127870
Isolation of P1 bacteriophage clones containing large contiguous segments of the human and mouse loci for the T-cell coreceptor molecule CD8.
Zhang XL, Lee KL, Heng HH, Tsui LC, Parnes JR, Shepherd NS, Chamberlain JW
Genet Anal Tech Appl. 1994
PubMed ID: 7710778
Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei.
Rottenberg ME, Bakhiet M, Olsson T, Kristensson K, Mak T, Wigzell H, Orn A
Infect Immun. 1993
PubMed ID: 8225589
The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]
Penninger JM, Neu N, Timms E, Wallace VA, Koh DR, Kishihara K, Pummerer C, Mak TW
J Exp Med. 1993
PubMed ID: 8228830
The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes.
Fung-Leung WP, Louie MC, Limmer A, Ohashi PS, Ngo K, Chen L, Kawai K, Lacy E, Loh DY, Mak TW
Eur J Immunol. 1993
PubMed ID: 8223860
Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8.
Schilham MW, Fung-Leung WP, Rahemtulla A, Kuendig T, Zhang L, Potter J, Miller RG, Hengartner H, Mak TW
Eur J Immunol. 1993
PubMed ID: 8500525
Linkage of the murine transforming growth factor alpha gene with Igk, Ly-2, and Fabp1 on chromosome 6.
Fowler KJ, Mann GB, Dunn AR
Genomics. 1993
PubMed ID: 8100806
CD8 is critically involved in lymphocyte activation by a T. brucei brucei-released molecule.
Olsson T, Bakhiet M, Höjeberg B, Ljungdahl A, Edlund C, Andersson G, Ekre HP, Fung-Leung WP, Mak T, Wigzell H
Cell. 1993
PubMed ID: 8453666
Differential susceptibility of mouse Lyt-2 and Lyt-3 genes to negative regulation.
Hwang I, Gu JJ, Gottlieb PD
Immunogenetics. 1993
PubMed ID: 8423051
CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny.
Fung-Leung WP, Wallace VA, Gray D, Sha WC, Pircher H, Teh HS, Loh DY, Mak TW
Eur J Immunol. 1993
PubMed ID: 8419174
CD45RA and CD45RBhigh expression induced by thymic selection events.
Wallace VA, Fung-Leung WP, Timms E, Gray D, Kishihara K, Loh DY, Penninger J, Mak TW
J Exp Med. 1992
PubMed ID: 1460424
Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells.
Morse HC
J Immunol. 1992
PubMed ID: 1431091
The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the "b"domain of C9.
Ninomiya H, Sims PJ
J Biol Chem. 1992
PubMed ID: 1377690
Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice.
Koh DR, Fung-Leung WP, Ho A, Gray D, Acha-Orbea H, Mak TW
Science. 1992
PubMed ID: 1589800
Localization of the IL-5 receptor gene to the distal half of murine chromosome 6 using recombinant inbred strains of mice.
Gough NM, Rakar S
Genomics. 1992
PubMed ID: 1572667
Generation of mutant mice lacking surface expression of CD4 or CD8 by gene targeting.
Mak TW, Rahemtulla A, Schilham M, Koh DR, Fung-Leung WP
J Autoimmun. 1992
PubMed ID: 1503636
Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5.
Beyers AD, Spruyt LL, Williams AF
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1372996
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution.
Leahy DJ, Axel R, Hendrickson WA
Cell. 1992
PubMed ID: 1547508
Recent duplication of the two human CD8 beta-chain genes.
Nakayama K, Kawachi Y, Tokito S, Minami N, Yamamoto R, Imai T, Gachelin G, Nakauchi H
J Immunol. 1992
PubMed ID: 1541829
Rapid physical mapping of cloned DNA on banded mouse chromosomes by fluorescence in situ hybridization.
Boyle AL, Feltquite DM, Dracopoli NC, Housman DE, Ward DC
Genomics. 1992
PubMed ID: 1733847
Activation of Lyt-2 associated with distant upstream insertion of an SL3-3 provirus.
Anson DS, Clarkin K, Hyman R
Immunogenetics. 1992
PubMed ID: 1587551
Physical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells.
Mittler RS, Rankin BM, Kiener PA
J Immunol. 1991
PubMed ID: 1834739
Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts.
Sanders SK, Giblin PA, Kavathas P
J Exp Med. 1991
PubMed ID: 1908512
Glycosylation sites identified by detection of glycosylated amino acids released from Edman degradation: the identification of Xaa-Pro-Xaa-Xaa as a motif for Thr-O-glycosylation.
Gooley AA, Classon BJ, Marschalek R, Williams KL
Biochem Biophys Res Commun. 1991
PubMed ID: 1908233
CD8 is needed for development of cytotoxic T cells but not helper T cells.
Fung-Leung WP, Schilham MW, Rahemtulla A, Kündig TM, Vollenweider M, Potter J, van Ewijk W, Mak TW
Cell. 1991
PubMed ID: 1673361
Regional distribution and partial molecular characterization of CD4-related mRNA in human brain and peripheral tissues.
Erickson JD, Trojanowski JQ, Eiden LE
Brain Res Mol Brain Res. 1991
PubMed ID: 1676132
Genes encoding ligands for deletion of V beta 11 T cells cosegregate with mammary tumour virus genomes.
Dyson PJ, Knight AM, Fairchild S, Simpson E, Tomonari K
Nature. 1991
PubMed ID: 1846950
Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.
Mitchell PJ, Timmons PM, Hébert JM, Rigby PW, Tjian R
Genes Dev. 1991
PubMed ID: 1989904
The NXSM recombinant inbred strains of mice: genetic profile for 58 loci including the Mtv proviral loci.
Eicher EM, Lee BK
Genetics. 1990
PubMed ID: 2165966
Localization of the rhodopsin gene to the distal half of mouse chromosome 6.
Elliott RW, Sparkes RS, Mohandas T, Grant SG, McGinnis JF
Genomics. 1990
PubMed ID: 2341153
Prp (proline-rich protein) genes linked to markers Es-12 (esterase-12), Ea-10 (erythrocyte alloantigen), and loci on distal mouse chromosome 6.
Azen EA, Davisson MT, Cherry M, Taylor BA
Genomics. 1989
PubMed ID: 2613230
Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.
Aruffo A, Seed B
J Immunol. 1989
PubMed ID: 2701945
Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. Characterization of the human CD8 alpha gene.
Norment AM, Lonberg N, Lacy E, Littman DR
J Immunol. 1989
PubMed ID: 2496167
The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.
Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE
Proc Natl Acad Sci U S A. 1989
PubMed ID: 2470098
Isolation and characterization of the mouse CD8 beta-chain (Ly-3) genes. Absence of an intervening sequence between V- and J-like gene segments.
Nakayama K, Shinkai YI, Okumura K, Nakauchi H
J Immunol. 1989
PubMed ID: 2784466
Genetic control of resistance to 3-methylcholanthrene-induced T-cell lymphoma in mice.
Ishizaka ST, Lilly F
Cancer Res. 1989
PubMed ID: 2783886
A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing.
Giblin P, Ledbetter JA, Kavathas P
Proc Natl Acad Sci U S A. 1989
PubMed ID: 2536941
Structure and expression of the gene encoding CD8 alpha chain (Leu-2/T8).
Nakayama K, Tokito S, Okumura K, Nakauchi H
Immunogenetics. 1989
PubMed ID: 2509342
Molecular biology and function of CD4 and CD8.
Parnes JR
Adv Immunol. 1989
PubMed ID: 2493728
A second subunit of CD8 is expressed in human T cells.
Norment AM, Littman DR
EMBO J. 1988
PubMed ID: 3145195
Murine hematopoietic cell surface antigen expression.
Holmes KL, Morse HC
Immunol Today. 1988
PubMed ID: 3076405
The Ig kappa L chain allelic groups among the Ig kappa haplotypes and Ig kappa crossover populations suggest a gene order.
D'Hoostelaere LA, Huppi K, Mock B, Mallett C, Potter M
J Immunol. 1988
PubMed ID: 2898504
Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression.
Gorman SD, Sun YH, Zamoyska R, Parnes JR
J Immunol. 1988
PubMed ID: 3258885
Ly-36: a new mouse lymphocyte alloantigen defined by a Mus musculus molossinus-specific monoclonal antibody and controlled by a gene linked to Ly-2/3 region on chromosome 6.
Nakamura S, Dairiki K, Ikegami S, Kochiya M, Fujimori T, Tamaoki N, Tada N
Immunogenetics. 1988
PubMed ID: 3378837
A new mouse lymphocyte alloantigen (Ly-35) controlled by the Ly-2/3 region on chromosome 6.
Ikegami S, Nakamura S, Dairiki K, Watanabe Y, Fujimori T, Tamaoki N, Tada N
Immunogenetics. 1988
PubMed ID: 3346044
Nucleotide sequence analysis of the C.AKR Lyt-2a gene: structural polymorphism in alleles encoding the Lyt-2.1 T-cell surface alloantigen.
Youn HJ, Harriss JV, Gottlieb PD
Immunogenetics. 1988
PubMed ID: 3267233
The organization of the immunoglobulin kappa locus in mice.
D'Hoostelaere L, Huppi K, Mock B, Mallett C, Gibson D, Hilgers J, Potter M
Curr Top Microbiol Immunol. 1988
PubMed ID: 3138071
Mapping of Igk-V genes using backcrossed laboratory and wild mice.
Rueff-Juy D, Drapier AM, Cazenave PA
Immunogenetics. 1988
PubMed ID: 2843459
Relationship between mouse Ly-2 and the Mus musculus molossinus-specific Ly-35 alloantigenic determinants.
Ikegami S, Nakamura S, Dairiki K, Watanabe Y, Fujimori T, Tamaoki N, Tada N
Immunogenetics. 1988
PubMed ID: 2459057
The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships.
Sweetser DA, Birkenmeier EH, Klisak IJ, Zollman S, Sparkes RS, Mohandas T, Lusis AJ, Gordon JI
J Biol Chem. 1987
PubMed ID: 2824476
Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.
Rubin MR, King W, Toth LE, Sawczuk IS, Levine MS, D'Eustachio P, Nguyen-Huu MC
Mol Cell Biol. 1987
PubMed ID: 2891029
Isolation and characterization of the gene for the murine T cell differentiation antigen and immunoglobulin-related molecule, Lyt-2.
Nakauchi H, Tagawa M, Nolan GP, Herzenberg LA
Nucleic Acids Res. 1987
PubMed ID: 3495785
Genetic nomenclature for loci controlling mouse lymphocyte antigens.
Morse HC, Shen FW, Hämmerling U
Immunogenetics. 1987
PubMed ID: 3817907
Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7.
Bućan M, Yang-Feng T, Colberg-Poley AM, Wolgemuth DJ, Guenet JL, Francke U, Lehrach H
EMBO J. 1986
PubMed ID: 2878803
An RFLP associated with pcDLeu2-14, a human T-cell differentiation antigen CD8 (Leu2) cDNA mapped to 2p12.
Bowcock AM, Kavathas P, Margolskee RF, Herzenberg L, Cavalli-Sforza LL
Nucleic Acids Res. 1986
PubMed ID: 2877435
Structure, sequence, and polymorphism of the Lyt-2 T cell differentiation antigen gene.
Liaw CW, Zamoyska R, Parnes JR
J Immunol. 1986
PubMed ID: 3487583
Formal proof that different-size Lyt-2 polypeptides arise from differential splicing and post-transcriptional regulation.
Tagawa M, Nakauchi H, Herzenberg LA, Nolan GP
Proc Natl Acad Sci U S A. 1986
PubMed ID: 3085089
Structural polymorphism of V kappa 21 E and V kappa 21 D gene products in laboratory mice.
Primi D, Barbier E, Cazenave PA
Eur J Immunol. 1986
PubMed ID: 3082651
Genetic polymorphism at the mouse immunoglobulin J kappa locus (Igk-J) as demonstrated by Southern hybridization and nucleotide sequence analysis.
Boyd RT, Goldrick MM, Gottlieb PD
Immunogenetics. 1986
PubMed ID: 2875941
Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA.
Zamoyska R, Vollmer AC, Sizer KC, Liaw CW, Parnes JR
Cell. 1985
PubMed ID: 3935316
Purification, chain separation and sequence of the MRC OX-8 antigen, a marker of rat cytotoxic T lymphocytes.
Johnson P, Gagnon J, Barclay AN, Williams AF
EMBO J. 1985
PubMed ID: 3932064
The major histocompatibility complex-restricted antigen receptor on T cells: the genetics of expression of an allotype.
Roehm NW, Carbone A, Kushnir E, Taylor BA, Riblet RJ, Marrack P, Kappler JW
J Immunol. 1985
PubMed ID: 2410514
Structure of Leu-2/T8 as deduced from the sequence of a cDNA clone.
Parnes JR, Sizer KC, Sukhatme VP, Hunkapiller T
Behring Inst Mitt. 1985
PubMed ID: 3936473
Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions.
Nakauchi H, Nolan GP, Hsu C, Huang HS, Kavathas P, Herzenberg LA
Proc Natl Acad Sci U S A. 1985
PubMed ID: 3927298
The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions.
Sukhatme VP, Sizer KC, Vollmer AC, Hunkapiller T, Parnes JR
Cell. 1985
PubMed ID: 3918796
Gene for the human T cell differentiation antigen Leu-2/T8 is closely linked to the kappa light chain locus on chromosome 2.
Sukhatme VP, Vollmer AC, Erikson J, Isobe M, Croce C, Parnes JR
J Exp Med. 1985
PubMed ID: 3919142
The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes.
Littman DR, Thomas Y, Maddon PJ, Chess L, Axel R
Cell. 1985
PubMed ID: 3871356
Linkage of a 7S RNA sequence and kappa light chain genes in the mouse.
Taylor BA, Rowe L, Gibson DM, Riblet R, Yetter R, Gottlieb PD
Immunogenetics. 1985
PubMed ID: 2998983
Ly antigens associated with T cell recognition and effector function.
Walker ID, Hogarth PM, Murray BJ, Lovering KE, Classon BJ, Chambers GW, McKenzie IF
Immunol Rev. 1984
PubMed ID: 6442265
Isolation of the gene encoding the human T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and cDNA subtraction.
Kavathas P, Sukhatme VP, Herzenberg LA, Parnes JR
Proc Natl Acad Sci U S A. 1984
PubMed ID: 6440142
Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice.
Davidson WF, Roths JB, Holmes KL, Rudikoff E, Morse HC
J Immunol. 1984
PubMed ID: 6610701
Recombination between kappa chain genetic markers in the mouse.
Gibson DM, MacLean SJ, Anctil D, Mathieson BJ
Immunogenetics. 1984
PubMed ID: 6437974
The T8 antigen is a multimeric complex of two distinct subunits on human thymocytes but consists of homomultimeric forms on peripheral blood T lymphocytes.
Snow PM, Terhorst C
J Biol Chem. 1983
PubMed ID: 6605969
Location on chromosome 6 of the locus for a major liver protein (Lvp-1) of the house mouse.
Wilcox FH, Roderick TH
Genet Res. 1982
PubMed ID: 7152259
Genetic mapping of endogenous mouse mammary tumor viruses: locus characterization, segregation, and chromosomal distribution.
Traina VL, Taylor BA, Cohen JC
J Virol. 1981
PubMed ID: 6275115
gamma-Glutamyl cyclotransferase: a new genetic polymorphism in the mouse (Mus musculus) linked to Lyt-2.
Tulchin N, Taylor BA
Genetics. 1981
PubMed ID: 6122625
Antibody gene linkage studies in (NZB X C58) recombinant-inbred lines.
Riblet R, Claflin L, Gibson DM, Mathieson BJ, Weigert M
J Immunol. 1980
PubMed ID: 6766165
Evidence for close linkage of a mouse light chain marker with the Ly-2,3 locus.
Gibson DM, Taylor BA, Cherry M
J Immunol. 1978
PubMed ID: 100557
Genetic characterization of important mouse strains used in cancer research.
Krog HH, Wysocka M, Kisielow P, Radzikowski C
Hereditas. 1977
PubMed ID: 75870
Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen.
Gottlieb PD
J Exp Med. 1974
PubMed ID: 4547628
Variations among sublines of inbred AKR mice.
Acton RT, Balankenhorn EP, Douglas TC, Owen RD, Hilgers J, Hoffman HA, Boyse EA
Nat New Biol. 1973
PubMed ID: 4353891
Genetic linkage relationships of loci specifying differentiation alloantigens in the mouse.
Itakura K, Hutton JJ, Boyse EA, Old LJ
Transplantation. 1972
PubMed ID: 5021438
Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse.
Boyse EA, Miyazawa M, Aoki T, Old LJ
Proc R Soc Lond B Biol Sci. 1968
PubMed ID: 4385242

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	925	12525	24930
EnsEMBL Gene(s)	ENSG00000153563 LRG_44	ENSMUSG00000053977	ENSRNOG00000007178
Unigene	Hs.85258	Mm.1858	Rn.10306
Homologene	CD8A	Cd8a	Cd8a
OMIM	186910	N/A	N/A
GeneCards	CD8A	N/A	N/A
Beta Cell Genomics	DT.100743986 DT.102838864 DT.441450 DT.95325740	DT.101174492 DT.101721974 DT.101724847 DT.528549	N/A
Reactome	P01732	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	925	12525	24930

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