MTA2

Summary Top Help

Gene Description:

metastasis-associated gene family, member 2; metastasis associated 1 family, member 2

Synonyms:

PID, mmta2, MTA2, MTA1L1, Mta2, Mta1l1, AW550797, Mata1l1

Orthologs:

Human MTA2 (protein-coding), Mouse Mta2 (protein-coding), Rat Mta2 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 1

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm25	Rat	chr1:193831373..230411453	36.58	585

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:62360675..62369312 (8.64 kb) View in Genome Browser

(Mouse) NCBIM37 - chr19:9016365..9026793 (10.43 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:211618426..211627147 (8.72 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for MTA2:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for MTA2:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 17

Publications from PubMed Top Help

Publications: 98

A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
Greco TM, Yu F, Guise AJ, Cristea IM
Mol Cell Proteomics. 2011
PubMed ID: 21081666
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity.
Hesse E, Saito H, Kiviranta R, Correa D, Yamana K, Neff L, Toben D, Duda G, Atfi A, Geoffroy V, Horne WC, Baron R
J Cell Biol. 2010
PubMed ID: 21173110
Metastasis Tumor Antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development.
Ma P, Lin S, Bartolomei MS, Schultz RM
Biol Reprod. 2010
PubMed ID: 20720167
GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2.
Hwang SS, Lee S, Lee W, Lee GR
Immunology. 2010
PubMed ID: 20636338
[Expression and significance of MTA2 in non-small cell lung cancer].
Wang S, Qi Y, Zhang J, Zhang Q, Li H, Qiu X
Zhongguo Fei Ai Za Zhi. 2010
PubMed ID: 20704817
Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
Xu G, Paige JS, Jaffrey SR
Nat Biotechnol. 2010
PubMed ID: 20639865
Network organization of the human autophagy system.
Behrends C, Sowa ME, Gygi SP, Harper JW
Nature. 2010
PubMed ID: 20562859
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Dev Cell. 2010
PubMed ID: 20412781
An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.
Pardo M, Lang B, Yu L, Prosser H, Bradley A, Babu MM, Choudhary J
Cell Stem Cell. 2010
PubMed ID: 20362542
An Oct4-centered protein interaction network in embryonic stem cells.
van den Berg DL, Snoek T, Mullin NP, Yates A, Bezstarosti K, Demmers J, Chambers I, Poot RA
Cell Stem Cell. 2010
PubMed ID: 20362541
Increased interaction between DJ-1 and the Mi-2/ nucleosome remodelling and deacetylase complex during cellular stress.
Opsahl JA, Hjørnevik LV, Bull VH, Fismen L, Frøyset AK, Gromyko D, Solstad T, Fladmark KE
Proteomics. 2010
PubMed ID: 20127688
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA.
Terhune SS, Moorman NJ, Cristea IM, Savaryn JP, Cuevas-Bennett C, Rout MP, Chait BT, Shenk T
PLoS Pathog. 2010
PubMed ID: 20585571
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex.
Banach-Orlowska M, Pilecka I, Torun A, Pyrzynska B, Miaczynska M
Biochem J. 2009
PubMed ID: 19686092
Translational isoforms of FOG1 regulate GATA1-interacting complexes.
Snow JW, Orkin SH
J Biol Chem. 2009
PubMed ID: 19654328
ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis.
Li R, Zhang H, Yu W, Chen Y, Gui B, Liang J, Wang Y, Sun L, Yang X, Zhang Y, Shi L, Li Y, Shang Y
EMBO J. 2009
PubMed ID: 19644445
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer.
Wang Y, Zhang H, Chen Y, Sun Y, Yang F, Yu W, Liang J, Sun L, Yang X, Shi L, Li R, Li Y, Zhang Y, Li Q, Yi X, Shang Y
Cell. 2009
PubMed ID: 19703393
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Overexpression of metastasis-associated protein 2 is associated with hepatocellular carcinoma size and differentiation.
Lee H, Ryu SH, Hong SS, Seo DD, Min HJ, Jang MK, Kwon HJ, Yu E, Chung YH, Kim KW
J Gastroenterol Hepatol. 2009
PubMed ID: 19702911
TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77.
Rambaud J, Desroches J, Balsalobre A, Drouin J
J Biol Chem. 2009
PubMed ID: 19321449
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.
Ouyang J, Shi Y, Valin A, Xuan Y, Gill G
Mol Cell. 2009
PubMed ID: 19394292
Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners.
Montes de Oca R, Shoemaker CJ, Gucek M, Cole RN, Wilson KL
PLoS One. 2009
PubMed ID: 19759913
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
In vitro nuclear interactome of the HIV-1 Tat protein.
Gautier VW, Gu L, O'Donoghue N, Pennington S, Sheehy N, Hall WW
Retrovirology. 2009
PubMed ID: 19454010
Members of the NuRD chromatin remodeling complex interact with AUF1 in developing cortical neurons.
Lee C, Gyorgy A, Maric D, Sadri N, Schneider RJ, Barker JL, Lawson M, Agoston DV
Cereb Cortex. 2008
PubMed ID: 18413351
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells.
Liang J, Wan M, Zhang Y, Gu P, Xin H, Jung SY, Qin J, Wong J, Cooney AJ, Liu D, Songyang Z
Nat Cell Biol. 2008
PubMed ID: 18454139
Switching of chromatin-remodelling complexes for oestrogen receptor-alpha.
Okada M, Takezawa S, Mezaki Y, Yamaoka I, Takada I, Kitagawa H, Kato S
EMBO Rep. 2008
PubMed ID: 18451880
Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice.
Lu X, Kovalev GI, Chang H, Kallin E, Knudsen G, Xia L, Mishra N, Ruiz P, Li E, Su L, Zhang Y
J Biol Chem. 2008
PubMed ID: 18353770
Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex.
Verstappen G, van Grunsven LA, Michiels C, Van de Putte T, Souopgui J, Van Damme J, Bellefroid E, Vandekerckhove J, Huylebroeck D
Hum Mol Genet. 2008
PubMed ID: 18182442
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR
J Proteome Res. 2008
PubMed ID: 18220336
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
SATB2 interacts with chromatin-remodeling molecules in differentiating cortical neurons.
Gyorgy AB, Szemes M, de Juan Romero C, Tarabykin V, Agoston DV
Eur J Neurosci. 2008
PubMed ID: 18333962
The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex.
Roche AE, Bassett BJ, Samant SA, Hong W, Blobel GA, Svensson EC
J Mol Cell Cardiol. 2008
PubMed ID: 18067919
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD
J Proteome Res. 2007
PubMed ID: 17924679
Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.
Sillibourne JE, Delaval B, Redick S, Sinha M, Doxsey SJ
Mol Biol Cell. 2007
PubMed ID: 17626165
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.
Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B
Mol Cell. 2007
PubMed ID: 17643375
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells.
Cui Y, Niu A, Pestell R, Kumar R, Curran EM, Liu Y, Fuqua SA
Mol Endocrinol. 2006
PubMed ID: 16645043
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
Nature. 2006
PubMed ID: 16554811
The NuRD component Mbd3 is required for pluripotency of embryonic stem cells.
Kaji K, Caballero IM, MacLeod R, Nichols J, Wilson VA, Hendrich B
Nat Cell Biol. 2006
PubMed ID: 16462733
Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.
McCracken S, Longman D, Marcon E, Moens P, Downey M, Nickerson JA, Jessberger R, Wilde A, Caceres JF, Emili A, Blencowe BJ
J Biol Chem. 2005
PubMed ID: 16159877
BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter.
Cismasiu VB, Adamo K, Gecewicz J, Duque J, Lin Q, Avram D
Oncogene. 2005
PubMed ID: 16091750
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
GATA-1 forms distinct activating and repressive complexes in erythroid cells.
Rodriguez P, Bonte E, Krijgsveld J, Kolodziej KE, Guyot B, Heck AJ, Vyas P, de Boer E, Grosveld F, Strouboulis J
EMBO J. 2005
PubMed ID: 15920471
MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.
Jin SG, Jiang CL, Rauch T, Li H, Pfeifer GP
J Biol Chem. 2005
PubMed ID: 15701600
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex.
Jiang CL, Jin SG, Pfeifer GP
J Biol Chem. 2004
PubMed ID: 15456747
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Genomic analysis of mouse retinal development.
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
PLoS Biol. 2004
PubMed ID: 15226823
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.
Miaczynska M, Christoforidis S, Giner A, Shevchenko A, Uttenweiler-Joseph S, Habermann B, Wilm M, Parton RG, Zerial M
Cell. 2004
PubMed ID: 15016378
Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis.
Zoltewicz JS, Stewart NJ, Leung R, Peterson AS
Development. 2004
PubMed ID: 14645126
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.
Yao YL, Yang WM
J Biol Chem. 2003
PubMed ID: 12920132
MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer.
Fujita N, Jaye DL, Kajita M, Geigerman C, Moreno CS, Wade PA
Cell. 2003
PubMed ID: 12705869
A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.
Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R
J Biol Chem. 2003
PubMed ID: 12493763
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase.
Sakai H, Urano T, Ookata K, Kim MH, Hirai Y, Saito M, Nojima Y, Ishikawa F
J Biol Chem. 2002
PubMed ID: 12354758
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
SATB1 targets chromatin remodelling to regulate genes over long distances.
Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T
Nature. 2002
PubMed ID: 12374985
The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.
Saito M, Ishikawa F
J Biol Chem. 2002
PubMed ID: 12124384
Murine Sall1 represses transcription by recruiting a histone deacetylase complex.
Kiefer SM, McDill BW, Yang J, Rauchman M
J Biol Chem. 2002
PubMed ID: 11836251
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.
Nishioka K, Chuikov S, Sarma K, Erdjument-Bromage H, Allis CD, Tempst P, Reinberg D
Genes Dev. 2002
PubMed ID: 11850410
Identification and functional characterization of the p66/p68 components of the MeCP1 complex.
Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y
Mol Cell Biol. 2002
PubMed ID: 11756549
Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation.
Pflum MK, Tong JK, Lane WS, Schreiber SL
J Biol Chem. 2001
PubMed ID: 11602581
Characterization of mouse metastasis-associated gene 2: genomic structure, nuclear localization signal, and alternative potentials as transcriptional activator and repressor.
Matsusue K, Takiguchi S, Toh Y, Kono A
DNA Cell Biol. 2001
PubMed ID: 11749719
Sp1 and ETS family transcription factors regulate the mouse Mta2 gene expression.
Xia L, Zhang Y
Gene. 2001
PubMed ID: 11368903
Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.
Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM
Genes Dev. 2001
PubMed ID: 11331609
The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes.
Feng Q, Zhang Y
Genes Dev. 2001
PubMed ID: 11297506
Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.
Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH
J Biol Chem. 2001
PubMed ID: 11102443
CoREST is an integral component of the CoREST- human histone deacetylase complex.
You A, Tong JK, Grozinger CM, Schreiber SL
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11171972
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Assignment of the metastasis-associated gene (Mta1) to mouse chromosome band 12F and the metastasis-associated gene 2 (Mta2) to mouse chromosome band 19B by fluorescence in situ hybridization.
Cui Q, Matsusue K, Toh Y, Kono A, Takiguchi S
Cytogenet Cell Genet. 2001
PubMed ID: 11856890
Deacetylation of p53 modulates its effect on cell growth and apoptosis.
Luo J, Su F, Chen D, Shiloh A, Gu W
Nature. 2000
PubMed ID: 11099047
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Histone deacetylase interacts directly with DNA topoisomerase II.
Tsai SC, Valkov N, Yang WM, Gump J, Sullivan D, Seto E
Nat Genet. 2000
PubMed ID: 11062478
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Identification of a nuclear domain with deacetylase activity.
Downes M, Ordentlich P, Kao HY, Alvarez JG, Evans RM
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10984530
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.
Schmidt DR, Schreiber SL
Biochemistry. 1999
PubMed ID: 10545197
Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation.
Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP
Nat Genet. 1999
PubMed ID: 10471500
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D
Genes Dev. 1999
PubMed ID: 10444591
Molecular cloning, mapping, and characterization of a novel human gene, MTA1-L1, showing homology to a metastasis-associated gene, MTA1.
Futamura M, Nishimori H, Shiratsuchi T, Saji S, Nakamura Y, Tokino T
J Hum Genet. 1999
PubMed ID: 9929979
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.
Xue Y, Wong J, Moreno GT, Young MK, Côté J, Wang W
Mol Cell. 1998
PubMed ID: 9885572
Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.
Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL
Nature. 1998
PubMed ID: 9804427
The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.
Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D
Cell. 1998
PubMed ID: 9790534

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	9219	23942	361724
EnsEMBL Gene(s)	ENSG00000149480	ENSMUSG00000071646	ENSRNOG00000019913
Unigene	Hs.173043	Mm.25339	Rn.137719
Homologene	MTA2	Mta2	Mta2
OMIM	603947	N/A	N/A
GeneCards	MTA2	N/A	N/A
Beta Cell Genomics	DT.100023584 DT.40120984 DT.97861405	DT.484725 DT.494217	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	ENSP00000278823	N/A	N/A
WikiGenes	9219	23942	361724

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
MTA2	HDAC5	BioGRID	empirical	21081666
MTA2	CHD3	IntAct, BioGRID	empirical	19703393 10444591 11297506
MTA2	CHD4	BioGRID	empirical	12920132 20362541 15920471 9790534 19703393
MTA2	PARK7	IntAct, BioGRID	empirical	20127688
MTA2	MBD3L2	BioGRID	empirical	15701600
MTA2	ZFPM1	BioGRID	empirical	19654328
MTA2	TSC22D3	IntAct	empirical	21988832
MTA2	ESR1	MINT, BioGRID	empirical	18451880 16645043
MTA2	ESR2	IntAct	empirical	21182203
MTA2	ESRRB	BioGRID	empirical	20362541
MTA2	FKBP3	BioGRID	empirical	12920132
MTA2	SPEN	HPRD	empirical	11331609
MTA2	KDM1A	IntAct, BioGRID	empirical	19703393
MTA2	SATB2	BioGRID	empirical	18333962
MTA2	ZFPM2	BioGRID	empirical	18067919
MTA2	SRRM2	BioGRID	empirical	16159877
MTA2	ZNF521	BioGRID	empirical	21173110
MTA2	SIN3A	BioGRID	empirical	12920132 11602581
MTA2	APPL1	HPRD, IntAct, BioGRID	empirical	15016378 19686092
MTA2	GATA1	BioGRID	empirical	15920471
MTA2	GBAS	IntAct, BioGRID	empirical	20562859
MTA2	GTF2E2	BioGRID	empirical	17643375
MTA2	TFCP2L1	BioGRID	empirical	20362541
MTA2	HDAC1	IntAct, BioGRID	empirical	19703393 20127688 21258344 14645126 12920132 11171972 10444591 12374985 19686092 16645043 15920471 11602581 11297506 11102443 9790534 20585571
MTA2	HDAC2	IntAct, BioGRID	empirical	19703393 21258344 12920132 12493763 10444591 19686092 18454139 15920471 11297506 11102443
MTA2	NR4A1	BioGRID	empirical	19321449
MTA2	HNRNPD	BioGRID	empirical	18413351
MTA2	PCNT	BioGRID	empirical	17626165
MTA2	BCL11A	BioGRID	empirical	16091750
MTA2	MBD3	HPRD, IntAct, BioGRID	empirical	12124384 18500823 19703393 12354758 10444591 20362541 18454139 15920471 11297506
MTA2	ATR	BioGRID	empirical	10545197
MTA2	POU5F1	IntAct, BioGRID	empirical	20362542 20362541 18454139
MTA2	APPL2	HPRD, IntAct, BioGRID	empirical	15016378
MTA2	CHD7	BioGRID	empirical	21532573
MTA2	SMARCAD1	BioGRID	empirical	21549307
MTA2	SALL4	BioGRID	empirical	20362541
MTA2	GATAD2B	BioGRID	empirical	11756549
MTA2	MTA3	IntAct	empirical	21258344
MTA2	RBBP4	HPRD, IntAct, BioGRID	empirical	14645126 19703393 12920132 10444591 19686092 15920471 11602581 11297506
MTA2	RBBP7	HPRD, IntAct, BioGRID	empirical	14645126 19703393 12920132 10444591 18454139 15920471 11297506
MTA2	SATB1	HPRD, BioGRID	empirical	12374985
MTA2	SOX2	BioGRID	empirical	21532573
MTA2	BRCA1	BioGRID	empirical	19703393
MTA2	BRCA2	IntAct	empirical	19703393
MTA2	TOP2B	BioGRID	empirical	11062478
MTA2	TP53	HPRD, BioGRID	empirical	11099047 12920132
MTA2	UBC	BioGRID	empirical	20639865 18781797 21139048 21890473 21906983
MTA2	YY1	BioGRID	empirical	12920132
MTA2	NANOG	BioGRID	empirical	18454139
MTA2	HIST1H3A	BioGRID	empirical	11850410
MTA2	MBD3L1	BioGRID	empirical	15456747
MTA2	SAP30	BioGRID	empirical	10444591
MTA2	MBD2	BioGRID	empirical	10444591 15920471 11297506 11102443
MTA2	MED30	BioGRID	empirical	20211142
MTA2	MTA1	BioGRID	empirical	12920132 20362541 18454139
MTA2	MTA2	BioGRID	empirical	12920132 18454139 15920471
MTA2	UBE3C	IntAct	empirical	21988832
MTA2	ULK2	IntAct	empirical	20562859
MTA2	ZEB2	BioGRID	empirical	18182442