CD4

Summary Top Help

Gene Description:

CD4 antigen; Cd4 molecule; CD4 molecule

Synonyms:

CD4mut, L3T4, CD4, W3/25, Ly-4, Cd4, p55

Orthologs:

Human CD4 (protein-coding), Mouse Cd4 (protein-coding), Rat Cd4 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd19	Mouse	chr6:117439553..128469043	11.03	187	2 no lod score

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr12:6896024..6929976 (33.95 kb) View in Genome Browser

(Mouse) NCBIM37 - chr6:124814710..124838239 (23.53 kb) View in Genome Browser

(Rat) RGSC3.4 - chr4:160988512..161014038 (25.53 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CD4:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CD4:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 5

Biocarta: 13

Reactome: 8

NCI-Nature Pathway Interaction Database: 8

Gene Ontology: 44

Publications from PubMed Top Help

Type 1 Diabetes Publications: 17

Possible association of the CD4 gene polymorphism with vitiligo in an Iranian population.
Zamani M, Tabatabaiefar MA, Mosayyebi S, Mashaghi A, Mansouri P
Clin Exp Dermatol. 2009
PubMed ID: 19843086
Upregulating CD4+CD25+FOXP3+ regulatory T cells in pancreatic lymph nodes in diabetic NOD mice by adjuvant immunotherapy.
Tian B, Hao J, Zhang Y, Tian L, Yi H, O'Brien TD, Sutherland DE, Hering BJ, Guo Z
Transplantation. 2009
PubMed ID: 19155973
Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells.
Chen G, Han G, Feng J, Wang J, Wang R, Xu R, Shen B, Qian J, Li Y
PLoS One. 2009
PubMed ID: 19759824
Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis.
Cardoso CR, Garlet GP, Moreira AP, Júnior WM, Rossi MA, Silva JS
J Leukoc Biol. 2008
PubMed ID: 18451325
Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic mice.
Fukushima K, Abiru N, Nagayama Y, Kobayashi M, Satoh T, Nakahara M, Kawasaki E, Yamasaki H, Ueha S, Matsushima K, Liu E, Eguchi K
Biochem Biophys Res Commun. 2008
PubMed ID: 18194666
Mechanisms of PDL1-mediated regulation of autoimmune diabetes.
Guleria I, Gubbels Bupp M, Dada S, Fife B, Tang Q, Ansari MJ, Trikudanathan S, Vadivel N, Fiorina P, Yagita H, Azuma M, Atkinson M, Bluestone JA, Sayegh MH
Clin Immunol. 2007
PubMed ID: 17627890
Deficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4+CD25+ T-cell-mediated regulation and type 1 diabetes development in NOD mice.
Alard P, Manirarora JN, Parnell SA, Hudkins JL, Clark SL, Kosiewicz MM
Diabetes. 2006
PubMed ID: 16804081
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.
Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, Tree TI
Diabetes. 2005
PubMed ID: 15616015
Evidence for tissue-directed immune responses: analysis of CD4- and CD8-dependent alloimmunity.
Lunsford KE, Gao D, Eiring AM, Wang Y, Frankel WL, Bumgardner GL
Transplantation. 2004
PubMed ID: 15502708
In a transgenic model of spontaneous autoimmune diabetes, expression of a protective class II MHC molecule results in thymic deletion of diabetogenic CD8+ T cells.
Morgan DJ, Nugent CT, Raveney BJ, Sherman LA
J Immunol. 2004
PubMed ID: 14707073
Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci.
Furuya T, Salstrom JL, McCall-Vining S, Cannon GW, Joe B, Remmers EF, Griffiths MM, Wilder RL
Hum Mol Genet. 2000
PubMed ID: 11001927
Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions.
Graser RT, DiLorenzo TP, Wang F, Christianson GJ, Chapman HD, Roopenian DC, Nathenson SG, Serreze DV
J Immunol. 2000
PubMed ID: 10725754
Rapid commitment to negative selection of a thymocyte line independent of CD4 co-engagement.
Kovalik JP, Ansari B, Boothby M
J Immunol. 1996
PubMed ID: 8955175
Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis.
Tada Y, Ho A, Koh DR, Mak TW
J Immunol. 1996
PubMed ID: 8666829
Hyporesponsiveness in contact hypersensitivity and irritant contact dermatitis in CD4 gene targeted mouse.
Kondo S, Beissert S, Wang B, Fujisawa H, Kooshesh F, Stratigos A, Granstein RD, Mak TW, Sauder DN
J Invest Dermatol. 1996
PubMed ID: 8618064
Autoimmune diabetes-prone NOD mice express the Lyt2 alpha (Lyt2.1) and Lyt3 alpha (Lyt3.1) alleles of CD8.
Johnson-Tardieu JM, Walworth EW, Cornelius JG, Ye X, Schuster SM, Peck AB
Immunogenetics. 1996
PubMed ID: 8537123
Glucose transporter gene expression in early mouse embryos.
Hogan A, Heyner S, Charron MJ, Copeland NG, Gilbert DJ, Jenkins NA, Thorens B, Schultz GA
Development. 1991
PubMed ID: 1765007

Publications: 1585

Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
Magadán JG, Bonifacino JS
J Virol. 2012
PubMed ID: 22090097
Expansion of a restricted residual host T reg-cell repertoire is dependent on IL-2 following experimental autologous hematopoietic stem transplantation.
Bayer AL, Chirinos J, Cabello C, Yang J, Matsutani T, Malek TR, Levy RB
Eur J Immunol. 2011
PubMed ID: 21928285
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L
Nature. 2011
PubMed ID: 22080947
Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence.
Nowell CS, Bredenkamp N, Tetélin S, Jin X, Tischner C, Vaidya H, Sheridan JM, Stenhouse FH, Heussen R, Smith AJ, Blackburn CC
PLoS Genet. 2011
PubMed ID: 22072979
Host immunity and pathogen strain contribute to intestinal disaccharidase impairment following gut infection.
Solaymani-Mohammadi S, Singer SM
J Immunol. 2011
PubMed ID: 21873528
Pancreatic cancer alters human CD4+ T lymphocyte function: a piece in the immune evasion puzzle.
Fogar P, Basso D, Fadi E, Greco E, Pantano G, Padoan A, Bozzato D, Facco M, Sanzari MC, Teolato S, Zambon CF, Navaglia F, Semenzato G, Pedrazzoli S, Plebani M
Pancreas. 2011
PubMed ID: 21792088
Inhibitory molecules that regulate expansion and restoration of HCV-specific CD4+ T cells in patients with chronic infection.
Raziorrouh B, Ulsenheimer A, Schraut W, Heeg M, Kurktschiev P, Zachoval R, Jung MC, Thimme R, Neumann-Haefelin C, Horster S, Wächtler M, Spannagl M, Haas J, Diepolder HM, Grüner NH
Gastroenterology. 2011
PubMed ID: 21763239
Increased CD4(+) CD69(+) CD25(-) T cells in patients with hepatocellular carcinoma are associated with tumor progression.
Zhu J, Feng A, Sun J, Jiang Z, Zhang G, Wang K, Hu S, Qu X
J Gastroenterol Hepatol. 2011
PubMed ID: 21557772
Decreased CXCR3 expression in CD4+ T cells exposed to asbestos or derived from asbestos-exposed patients.
Maeda M, Nishimura Y, Hayashi H, Kumagai N, Chen Y, Murakami S, Miura Y, Hiratsuka J, Kishimoto T, Otsuki T
Am J Respir Cell Mol Biol. 2011
PubMed ID: 21357438
Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.
Wang XX, Li Y, Yin Y, Mo M, Wang Q, Gao W, Wang L, Mariuzza RA
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21900604
Design and characterization of stabilized derivatives of human CD4D12 and CD4D1.
Saha P, Barua B, Bhattacharyya S, Balamurali MM, Schief WR, Baker D, Varadarajan R
Biochemistry. 2011
PubMed ID: 21827143
Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene.
Egawa T, Littman DR
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21873191
Stimulation-dependent induction of CD154 on a subset of CD4+ FoxP3+ T-regulatory cells.
Li W, Carlson TL, Green WR
Int Immunopharmacol. 2011
PubMed ID: 21496498
Unsymmetrical cyclotriazadisulfonamide (CADA) compounds as human CD4 receptor down-modulating agents.
Demillo VG, Goulinet-Mateo F, Kim J, Schols D, Vermeire K, Bell TW
J Med Chem. 2011
PubMed ID: 21800875
Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients.
Vallotton L, Hadaya K, Venetz JP, Buehler LH, Ciuffreda D, Nseir G, Codarri L, Villard J, Pantaleo G, Pascual M
Clin J Am Soc Nephrol. 2011
PubMed ID: 21757642
M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells.
Heusinkveld M, de Vos van Steenwijk PJ, Goedemans R, Ramwadhdoebe TH, Gorter A, Welters MJ, van Hall T, van der Burg SH
J Immunol. 2011
PubMed ID: 21709158
Complement regulates CD4 T-cell help to CD8 T cells required for murine allograft rejection.
Vieyra M, Leisman S, Raedler H, Kwan WH, Yang M, Strainic MG, Medof ME, Heeger PS
Am J Pathol. 2011
PubMed ID: 21704012
T-cell help permits memory CD8(+) T-cell inflation during cytomegalovirus latency.
Walton SM, Torti N, Mandaric S, Oxenius A
Eur J Immunol. 2011
PubMed ID: 21590767
Activation of the receptor NKG2D leads to production of Th17 cytokines in CD4+ T cells of patients with Crohn's disease.
Pariente B, Mocan I, Camus M, Dutertre CA, Ettersperger J, Cattan P, Gornet JM, Dulphy N, Charron D, Lémann M, Toubert A, Allez M
Gastroenterology. 2011
PubMed ID: 21600899
Altered cytokine levels and increased CD4+CD57+ T cells in the peripheral blood of hepatitis C virus-related hepatocellular carcinoma patients.
Shiraki T, Takayama E, Magari H, Nakata T, Maekita T, Enomoto S, Mori Y, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Mizuno-Kamiya M, Yashiro K, Iguchi M, Tamai H, Kameyama Y, Kato J, Kondoh N, Ichinose M
Oncol Rep. 2011
PubMed ID: 21491089
CD4+CD28 null T lymphocytes are expanded in young women with polycystic ovary syndrome.
Niccoli G, Apa R, Lanzone A, Liuzzo G, Spaziani C, Sagnella F, Cosentino N, Moro F, Martinez D, Morciano A, Bacà M, Pazzano V, Gangale MF, Tropea A, Crea F
Fertil Steril. 2011
PubMed ID: 21324454
CDK6 kinase activity is required for thymocyte development.
Hu MG, Deshpande A, Schlichting N, Hinds EA, Mao C, Dose M, Hu GF, Van Etten RA, Gounari F, Hinds PW
Blood. 2011
PubMed ID: 21508411
CD4+CD25+Foxp3+ regulatory T cells are dispensable for controlling CD8+ T cell-mediated lung inflammation.
Tosiek MJ, Gruber AD, Bader SR, Mauel S, Hoymann HG, Prettin S, Tschernig T, Buer J, Gereke M, Bruder D
J Immunol. 2011
PubMed ID: 21518973
Small intestine CD11c+ CD8+ T cells suppress CD4+ T cell-induced immune colitis.
Fujiwara D, Chen L, Wei B, Braun J
Am J Physiol Gastrointest Liver Physiol. 2011
PubMed ID: 21436315
High mobility group box-1 protein regulate immunosuppression of regulatory T cells through toll-like receptor 4.
Zhu XM, Yao YM, Liang HP, Xu CT, Dong N, Yu Y, Sheng ZY
Cytokine. 2011
PubMed ID: 21419643
Human colonic myofibroblasts promote expansion of CD4+ CD25high Foxp3+ regulatory T cells.
Pinchuk IV, Beswick EJ, Saada JI, Boya G, Schmitt D, Raju GS, Brenmoehl J, Rogler G, Reyes VE, Powell DW
Gastroenterology. 2011
PubMed ID: 21376048
CD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input.
Kumamoto Y, Mattei LM, Sellers S, Payne GW, Iwasaki A
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21555577
The integrins Mac-1 and alpha4beta1 perform crucial roles in neutrophil and T cell recruitment to lungs during Streptococcus pneumoniae infection.
Kadioglu A, De Filippo K, Bangert M, Fernandes VE, Richards L, Jones K, Andrew PW, Hogg N
J Immunol. 2011
PubMed ID: 21460207
Prolonged antitumor NK cell reactivity elicited by CXCL10-expressing dendritic cells licensed by CD40L+ CD4+ memory T cells.
Shimizu K, Asakura M, Fujii S
J Immunol. 2011
PubMed ID: 21460206
Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors.
Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ
Cancer Res. 2011
PubMed ID: 21430066
Stromal down-regulation of macrophage CD4/CCR5 expression and NF-κB activation mediates HIV-1 non-permissiveness in intestinal macrophages.
Shen R, Meng G, Ochsenbauer C, Clapham PR, Grams J, Novak L, Kappes JC, Smythies LE, Smith PD
PLoS Pathog. 2011
PubMed ID: 21637819
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.
Motomura Y, Kitamura H, Hijikata A, Matsunaga Y, Matsumoto K, Inoue H, Atarashi K, Hori S, Watarai H, Zhu J, Taniguchi M, Kubo M
Nat Immunol. 2011
PubMed ID: 21460847
CD4+T-bet+, CD4+pSTAT3+ and CD8+T-bet+ T cells accumulate in peripheral blood during NZB treatment.
Frisullo G, Iorio R, Plantone D, Marti A, Nociti V, Patanella AK, Batocchi AP
Mult Scler. 2011
PubMed ID: 21177324
Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells.
Benson HL, Mobashery S, Chang M, Kheradmand F, Hong JS, Smith GN, Shilling RA, Wilkes DS
Am J Respir Cell Mol Biol. 2011
PubMed ID: 20639459
Conformational and structural features of HIV-1 gp120 underlying the dual receptor antagonism by cross-reactive neutralizing antibody m18.
Gift SK, Zentner IJ, Schön A, McFadden K, Umashankara M, Rajagopal S, Contarino M, Duffy C, Courter JR, Zhang MY, Gershoni JM, Cocklin S, Dimitrov DS, Smith AB, Freire E, Chaiken IM
Biochemistry. 2011
PubMed ID: 21351734
Impaired in vivo CD4+ T cell expansion and differentiation in aged mice is not solely due to T cell defects: decreased stimulation by aged dendritic cells.
Pereira LF, de Souza AP, Borges TJ, Bonorino C
Mech Ageing Dev. 2011
PubMed ID: 21453718
Role of CD4 and CD8 T-lymphocytes, B-lymphocytes and Natural Killer cells in the prediction of radiation-induced late toxicity in cervical cancer patients.
Bordón E, Henríquez-Hernández LA, Lara PC, Pinar B, Rodríguez-Gallego C, Lloret M
Int J Radiat Biol. 2011
PubMed ID: 21142701
RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation.
Collins A, Hewitt SL, Chaumeil J, Sellars M, Micsinai M, Allinne J, Parisi F, Nora EP, Bolland DJ, Corcoran AE, Kluger Y, Bosselut R, Ellmeier W, Chong MM, Littman DR, Skok JA
Immunity. 2011
PubMed ID: 21435585
CD4 and CD8 T cell immune activation during chronic HIV infection: roles of homeostasis, HIV, type I IFN, and IL-7.
Catalfamo M, Wilhelm C, Tcheung L, Proschan M, Friesen T, Park JH, Adelsberger J, Baseler M, Maldarelli F, Davey R, Roby G, Rehm C, Lane C
J Immunol. 2011
PubMed ID: 21257970
Development of cytomegalovirus and adenovirus-specific memory CD4 T-cell functions from birth to adulthood.
Pédron B, Guérin V, Cordeiro DJ, Masmoudi S, Dalle JH, Sterkers G
Pediatr Res. 2011
PubMed ID: 21057376
Type I IFN substitutes for T cell help during viral infections.
Wiesel M, Kratky W, Oxenius A
J Immunol. 2011
PubMed ID: 21160039
The effect of CD4 receptor downregulation and its downstream signaling molecules on HIV-1 latency.
Kim KC, Kim HG, Roh TY, Park J, Jung KM, Lee JS, Choi SY, Kim SS, Choi BS
Biochem Biophys Res Commun. 2011
PubMed ID: 21146497
Endogenous collagen peptide activation of CD1d-restricted NKT cells ameliorates tissue-specific inflammation in mice.
Liu Y, Teige A, Mondoc E, Ibrahim S, Holmdahl R, Issazadeh-Navikas S
J Clin Invest. 2011
PubMed ID: 21157037
High frequency of CD4+ CXCR5+ TFH cells in patients with immune-active chronic hepatitis B.
Feng J, Lu L, Hua C, Qin L, Zhao P, Wang J, Wang Y, Li W, Shi X, Jiang Y
PLoS One. 2011
PubMed ID: 21750724
Loss of surface antigens is a conserved feature of apoptotic lymphocytes from several mammalian species.
Diaz D, Chara L, Chevarria J, Ubeda M, Muñoz L, Barcenilla H, Sánchez MA, Moreno Z, Monserrat J, Albillos A, Prieto A, Alvarez-Mon M
Cell Immunol. 2011
PubMed ID: 21745657
CD4+CD25+ and CD4+CD2+high regulatory T cells in disseminated and localized forms of allergic contact dermatitis: relation to specific cytokines.
Reduta T, Stasiak-Barmuta A, Laudańska H
Folia Histochem Cytobiol. 2011
PubMed ID: 21744325
Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPD.
Roos-Engstrand E, Pourazar J, Behndig AF, Bucht A, Blomberg A
Respir Res. 2011
PubMed ID: 21651772
CD8+CD122+ regulatory T cells (Tregs) and CD4+ Tregs cooperatively prevent and cure CD4+ cell-induced colitis.
Endharti AT, Okuno Y, Shi Z, Misawa N, Toyokuni S, Ito M, Isobe K, Suzuki H
J Immunol. 2011
PubMed ID: 21098236
CD4 co-receptor dependent signaling promotes competency for re-stimulation induced cell death of effector T cells.
Tinsley KW, Herzog D, Leitenberg D
Cell Immunol. 2011
PubMed ID: 21071017
CD4(+) T-cells are important in regulating macrophage polarization in C57BL/6 wild-type mice.
Chan T, Pek EA, Huth K, Ashkar AA
Cell Immunol. 2011
PubMed ID: 21040907
CD4 Intragenic SNPs Associate With HIV-2 Plasma Viral Load and CD4 Count in a Community-Based Study From Guinea-Bissau, West Africa.
Hennig BJ, Velez-Edwards DR, Schim van der Loeff MF, Bisseye C, Edwards TL, Tacconelli A, Novelli G, Aaby P, Kaye S, Scott WK, Jaye A, Whittle HC, Williams SM, Hill AV, Sirugo G
J Acquir Immune Defic Syndr. 2011
PubMed ID: 20924289
CD4 downregulation by the human immunodeficiency virus type 1 Nef protein is dispensable for optimal output and functionality of viral particles in primary T cells.
Neri F, Giolo G, Potestà M, Petrini S, Doria M
J Gen Virol. 2011
PubMed ID: 20881088
Transcriptional characteristics of CD4+ T cells in multiple sclerosis: relative lack of suppressive populations in blood.
Edström M, Mellergård J, Mjösberg J, Jenmalm M, Vrethem M, Press R, Dahle C, Ernerudh J
Mult Scler. 2011
PubMed ID: 20847001
Reduced monomeric CD4 is the preferred receptor for HIV.
Matthias LJ, Azimi I, Tabrett CA, Hogg PJ
J Biol Chem. 2010
PubMed ID: 20974843
Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody.
Freeman MM, Seaman MS, Rits-Volloch S, Hong X, Kao CY, Ho DD, Chen B
Structure. 2010
PubMed ID: 21134642
CD4+CD25+Foxp3+ regulatory T cells protect the proinflammatory activation of human umbilical vein endothelial cells.
He S, Li M, Ma X, Lin J, Li D
Arterioscler Thromb Vasc Biol. 2010
PubMed ID: 20930173
MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X
Carcinogenesis. 2010
PubMed ID: 20819778
CD4+CD25+ regulatory T cells attenuate cisplatin-induced nephrotoxicity in mice.
Lee H, Nho D, Chung HS, Lee H, Shin MK, Kim SH, Bae H
Kidney Int. 2010
PubMed ID: 20463654
The role of CD4-dependent signaling in interleukin-16 induced c-Fos expression and facilitation of neurite outgrowth in cerebellar granule neurons.
Fenster CP, Chisnell HK, Fry CR, Fenster SD
Neurosci Lett. 2010
PubMed ID: 20849916
TIM-3: a novel regulatory molecule of alloimmune activation.
Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N
J Immunol. 2010
PubMed ID: 20956339
Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
Astragalus membranaceus injection delayed allograft survival related with CD4+ CD25+ regulatory T cells.
Qu LL, Su YL, Li CX, Hou GH
Transplant Proc. 2010
PubMed ID: 21094858
Quality control for unfolded proteins at the plasma membrane.
Apaja PM, Xu H, Lukacs GL
J Cell Biol. 2010
PubMed ID: 20974815
Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses.
Wiesel M, Joller N, Ehlert AK, Crouse J, Spörri R, Bachmann MF, Oxenius A
J Immunol. 2010
PubMed ID: 20881183
CD4+ CD25+ but not CD4+ Foxp3+ T cells as a regulatory subset in primary biliary cirrhosis.
Wang D, Zhang H, Liang J, Gu Z, Zhou Q, Fan X, Hou Y, Sun L
Cell Mol Immunol. 2010
PubMed ID: 20729906
Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells.
Swaims AY, Khani F, Zhang Y, Roberts AI, Devadas S, Shi Y, Rabson AB
Blood. 2010
PubMed ID: 20634377
The number of cytomegalovirus-specific CD4+ T cells is markedly expanded in patients with B-cell chronic lymphocytic leukemia and determines the total CD4+ T-cell repertoire.
Pourgheysari B, Bruton R, Parry H, Billingham L, Fegan C, Murray J, Moss P
Blood. 2010
PubMed ID: 20562332
IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.
Yi JS, Ingram JT, Zajac AJ
J Immunol. 2010
PubMed ID: 20844201
HIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanisms.
Andrew A, Strebel K
Mol Aspects Med. 2010
PubMed ID: 20858517
HIV-1 Nef disrupts maturation of CD4+ T cells through CD4/Lck modulation.
Chrobak P, Simard MC, Bouchard N, Ndolo TM, Guertin J, Hanna Z, Dave V, Jolicoeur P
J Immunol. 2010
PubMed ID: 20826747
CD4 dimerization requires two cysteines in the cytoplasmic domain of the molecule and occurs in microdomains distinct from lipid rafts.
Fournier M, Peyrou M, Bourgoin L, Maeder C, Tchou I, Foti M
Mol Immunol. 2010
PubMed ID: 20739067
The associations of circulating CD4+CD25high regulatory T cells and TGF-β with disease activity and clinical course in patients with adult-onset Still's disease.
Chen DY, Chen YM, Chen HH, Hsieh CW, Lin CC, Lan JL
Connect Tissue Res. 2010
PubMed ID: 20388015
Homeostatic turnover of virus-specific memory CD8 T cells occurs stochastically and is independent of CD4 T cell help.
Choo DK, Murali-Krishna K, Anita R, Ahmed R
J Immunol. 2010
PubMed ID: 20733203
Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levels.
Mackerness KJ, Cox MA, Lilly LM, Weaver CT, Harrington LE, Zajac AJ
J Immunol. 2010
PubMed ID: 20720198
Pillars article: the CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. 1988.
Rudd CE, Trevillyan JM, Dasgupta JD, Wong LL, Schlossman SF
J Immunol. 2010
PubMed ID: 20724730
The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells.
Wang L, Carr T, Xiong Y, Wildt KF, Zhu J, Feigenbaum L, Bendelac A, Bosselut R
Eur J Immunol. 2010
PubMed ID: 20706986
The lung is an important site for priming CD4 T-cell-mediated protective immunity against gastrointestinal helminth parasites.
Harvie M, Camberis M, Tang SC, Delahunt B, Paul W, Le Gros G
Infect Immun. 2010
PubMed ID: 20605978
CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice.
Sun X, Wu Y, Gao W, Enjyoji K, Csizmadia E, Müller CE, Murakami T, Robson SC
Gastroenterology. 2010
PubMed ID: 20546740
Circulating CD4+CD25hiCD127lo regulatory T-Cell levels do not reflect the extent or severity of carotid and coronary atherosclerosis.
Ammirati E, Cianflone D, Banfi M, Vecchio V, Palini A, De Metrio M, Marenzi G, Panciroli C, Tumminello G, Anzuini A, Palloshi A, Grigore L, Garlaschelli K, Tramontana S, Tavano D, Airoldi F, Manfredi AA, Catapano AL, Norata GD
Arterioscler Thromb Vasc Biol. 2010
PubMed ID: 20539016
Association between anti-beta2 glycoprotein I antibodies and renal glomerular C4d deposition in lupus nephritis patients with glomerular microthrombosis: a prospective study of 155 cases.
Shen Y, Chen XW, Sun CY, Dai M, Yan YC, Yang CD
Lupus. 2010
PubMed ID: 20504833
Deficient CD4+CD25+ T regulatory cell function in patients with abdominal aortic aneurysms.
Yin M, Zhang J, Wang Y, Wang S, Böckler D, Duan Z, Xin S
Arterioscler Thromb Vasc Biol. 2010
PubMed ID: 20448211
Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK.
Gasser A, Cheng X, Gilmore ES, Tyrrell L, Waxman SG, Dib-Hajj SD
J Biol Chem. 2010
PubMed ID: 20530479
Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells.
Schenkel JM, Zloza A, Li W, Narasipura SD, Al-Harthi L
J Immunol. 2010
PubMed ID: 20631314
Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
Lee KM, Baris D, Zhang Y, Hosgood HD, Menashe I, Yeager M, Zahm SH, Wang SS, Purdue MP, Chanock S, Zheng T, Rothman N, Lan Q
Am J Hematol. 2010
PubMed ID: 20568250
Yersinia enterocolitica promotes robust mucosal inflammatory T-cell immunity in murine neonates.
Echeverry A, Saijo S, Schesser K, Adkins B
Infect Immun. 2010
PubMed ID: 20515925
Allergen-specific IL-10-secreting type I T regulatory cells, but not CD4(+)CD25(+)Foxp3(+) T cells, are decreased in peripheral blood of patients with persistent allergic rhinitis.
Han D, Wang C, Lou W, Gu Y, Wang Y, Zhang L
Clin Immunol. 2010
PubMed ID: 20403730
Epitope mapping of ibalizumab, a humanized anti-CD4 monoclonal antibody with anti-HIV-1 activity in infected patients.
Song R, Franco D, Kao CY, Yu F, Huang Y, Ho DD
J Virol. 2010
PubMed ID: 20463063
B cells require "nurturing" by CD4 T cells during development in order to respond in chronic graft-versus-host model of systemic lupus erythematosus.
Choudhury A, Cohen PL, Eisenberg RA
Clin Immunol. 2010
PubMed ID: 20381429
Differential subcellular localization of the regulatory T-cell protein LAG-3 and the coreceptor CD4.
Woo SR, Li N, Bruno TC, Forbes K, Brown S, Workman C, Drake CG, Vignali DA
Eur J Immunol. 2010
PubMed ID: 20391435
Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition.
Choi RY, Farquhar C, Juno J, Mbori-Ngacha D, Lohman-Payne B, Vouriot F, Wayne S, Tuff J, Bosire R, John-Stewart G, Fowke K
Clin Exp Immunol. 2010
PubMed ID: 20132229
Molecular analysis of tumor-promoting CD8+ T cells in two-stage cutaneous chemical carcinogenesis.
Kwong BY, Roberts SJ, Silberzahn T, Filler RB, Neustadter JH, Galan A, Reddy S, Lin WM, Ellis PD, Langford CF, Hayday AC, Girardi M
J Invest Dermatol. 2010
PubMed ID: 19924136
Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation.
Nishikawa Y, Hirota F, Yano M, Kitajima H, Miyazaki J, Kawamoto H, Mouri Y, Matsumoto M
J Exp Med. 2010
PubMed ID: 20404099
Histone acetylation at the single-cell level: a marker of memory CD8+ T cell differentiation and functionality.
Dispirito JR, Shen H
J Immunol. 2010
PubMed ID: 20308634
Impact of immunosuppressants on the therapeutic efficacy of in vitro-expanded CD4+CD25+Foxp3+ regulatory T cells in allotransplantation.
Lim DG, Koo SK, Park YH, Kim Y, Kim HM, Park CS, Kim SC, Han DJ
Transplantation. 2010
PubMed ID: 20305583
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma.
Yagi R, Junttila IS, Wei G, Urban JF, Zhao K, Paul WE, Zhu J
Immunity. 2010
PubMed ID: 20399120
Ontogeny of stromal organizer cells during lymph node development.
Bénézech C, White A, Mader E, Serre K, Parnell S, Pfeffer K, Ware CF, Anderson G, Caamaño JH
J Immunol. 2010
PubMed ID: 20237296
Mouse models for breast cancer metastasis.
Kim IS, Baek SH
Biochem Biophys Res Commun. 2010
PubMed ID: 20230796
Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps.
Magadán JG, Pérez-Victoria FJ, Sougrat R, Ye Y, Strebel K, Bonifacino JS
PLoS Pathog. 2010
PubMed ID: 20442859
Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells.
Chong MM, Simpson N, Ciofani M, Chen G, Collins A, Littman DR
Genes Dev. 2010
PubMed ID: 20360383
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase.
Reijmers RM, Vondenhoff MF, Roozendaal R, Kuil A, Li JP, Spaargaren M, Pals ST, Mebius RE
J Immunol. 2010
PubMed ID: 20208005
Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions.
Finzi A, Xiang SH, Pacheco B, Wang L, Haight J, Kassa A, Danek B, Pancera M, Kwong PD, Sodroski J
Mol Cell. 2010
PubMed ID: 20227370
Recombinant human erythropoietin treatment of chronic renal failure patients normalizes altered phenotype and proliferation of CD4-positive T lymphocytes.
Lisowska KA, Debska-Slizien A, Radzka M, Witkowski JM, Rutkowski B, Bryl E
Artif Organs. 2010
PubMed ID: 20447038
Decreased CD4+CD25+ cells and increased dimeric IgA-producing cells in tonsils in IgA nephropathy.
Huang H, Peng Y, Liu H, Yang X, Liu F
J Nephrol. 2010
PubMed ID: 20213609
Flt3-L increases CD4+CD25+Foxp3+ICOS+ cells in the lungs of cockroach-sensitized and -challenged mice.
McGee HS, Edwan JH, Agrawal DK
Am J Respir Cell Mol Biol. 2010
PubMed ID: 19448155
Interleukin-15 and its receptor augment dendritic cell vaccination against the neu oncogene through the induction of antibodies partially independent of CD4 help.
Steel JC, Ramlogan CA, Yu P, Sakai Y, Forni G, Waldmann TA, Morris JC
Cancer Res. 2010
PubMed ID: 20086176
Immune effectors required for hepatitis B virus clearance.
Yang PL, Althage A, Chung J, Maier H, Wieland S, Isogawa M, Chisari FV
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20080755
Increased bone marrow interleukin-7 (IL-7)/IL-7R levels but reduced IL-7 responsiveness in HIV-positive patients lacking CD4+ gain on antiviral therapy.
Bellistrì GM, Casabianca A, Merlini E, Orlandi C, Ferrario G, Meroni L, Galli M, Magnani M, Monforte A, Marchetti G
PLoS One. 2010
PubMed ID: 21209878
Selective induction of DNA repair pathways in human B cells activated by CD4+ T cells.
Wu X, Tschumper RC, Gutierrez A, Mihalcik SA, Nowakowski GS, Jelinek DF
PLoS One. 2010
PubMed ID: 21179576
Characterization of protective human CD4CD25 FOXP3 regulatory T cells generated with IL-2, TGF-β and retinoic acid.
Lu L, Zhou X, Wang J, Zheng SG, Horwitz DA
PLoS One. 2010
PubMed ID: 21179414
Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4+CD25+ regulatory T cells.
Borges TJ, Porto BN, Teixeira CA, Rodrigues M, Machado FD, Ornaghi AP, de Souza AP, Maito F, Pavanelli WR, Silva JS, Bonorino C
PLoS One. 2010
PubMed ID: 21170379
NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigenspecific CD4+ T cell polarization.
Hodgkins SR, Ather JL, Paveglio SA, Allard JL, LeClair LA, Suratt BT, Boyson JE, Poynter ME
Respir Res. 2010
PubMed ID: 20659336
Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites.
Bueno LL, Morais CG, Araújo FF, Gomes JA, Corrêa-Oliveira R, Soares IS, Lacerda MV, Fujiwara RT, Braga EM
PLoS One. 2010
PubMed ID: 20224778
A flow cytometry-based FRET assay to identify and analyse protein-protein interactions in living cells.
Banning C, Votteler J, Hoffmann D, Koppensteiner H, Warmer M, Reimer R, Kirchhoff F, Schubert U, Hauber J, Schindler M
PLoS One. 2010
PubMed ID: 20179761
Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue.
Schindler M, Rajan D, Banning C, Wimmer P, Koppensteiner H, Iwanski A, Specht A, Sauter D, Dobner T, Kirchhoff F
Retrovirology. 2010
PubMed ID: 20078884
GATA-3 is required for early T lineage progenitor development.
Hosoya T, Kuroha T, Moriguchi T, Cummings D, Maillard I, Lim KC, Engel JD
J Exp Med. 2009
PubMed ID: 19934022
IFN-gamma expressed by T cells regulates the persistence of antigen presentation by limiting the survival of dendritic cells.
Russell MS, Dudani R, Krishnan L, Sad S
J Immunol. 2009
PubMed ID: 19923462
Cutting edge: inhibitory effects of CD4 and CD8 on T cell activation induced by high-affinity noncognate ligands.
Chervin AS, Stone JD, Bowerman NA, Kranz DM
J Immunol. 2009
PubMed ID: 19923452
The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.
Cicala C, Martinelli E, McNally JP, Goode DJ, Gopaul R, Hiatt J, Jelicic K, Kottilil S, Macleod K, O'Shea A, Patel N, Van Ryk D, Wei D, Pascuccio M, Yi L, McKinnon L, Izulla P, Kimani J, Kaul R, Fauci AS, Arthos J
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19933330
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q
Occup Environ Med. 2009
PubMed ID: 19773279
Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
van de Pavert SA, Olivier BJ, Goverse G, Vondenhoff MF, Greuter M, Beke P, Kusser K, Höpken UE, Lipp M, Niederreither K, Blomhoff R, Sitnik K, Agace WW, Randall TD, de Jonge WJ, Mebius RE
Nat Immunol. 2009
PubMed ID: 19783990
A quantitative affinity-profiling system that reveals distinct CD4/CCR5 usage patterns among human immunodeficiency virus type 1 and simian immunodeficiency virus strains.
Johnston SH, Lobritz MA, Nguyen S, Lassen K, Delair S, Posta F, Bryson YJ, Arts EJ, Chou T, Lee B
J Virol. 2009
PubMed ID: 19692480
Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4.
Agrawal-Gamse C, Lee FH, Haggarty B, Jordan AP, Yi Y, Lee B, Collman RG, Hoxie JA, Doms RW, Laakso MM
J Virol. 2009
PubMed ID: 19692476
CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury.
D'Alessio FR, Tsushima K, Aggarwal NR, West EE, Willett MH, Britos MF, Pipeling MR, Brower RG, Tuder RM, McDyer JF, King LS
J Clin Invest. 2009
PubMed ID: 19770521
Cutting edge: CD4-independent development of functional FoxP3+ regulatory t cells.
Blache C, Adriouch S, Calbo S, Drouot L, Dulauroy S, Arnoult C, Le Corre S, Six A, Seman M, Boyer O
J Immunol. 2009
PubMed ID: 19767568
The CD4(+)CD8(+) and CD4(+) subsets of FOXP3(+) thymocytes differ in their response to growth factor deprivation or stimulation.
Lehtoviita A, Rossi LH, Kekäläinen E, Sairanen H, Arstila TP
Scand J Immunol. 2009
PubMed ID: 19751272
Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells.
Channappanavar R, Twardy BS, Krishna P, Suvas S
Mech Ageing Dev. 2009
PubMed ID: 19715717
Selective expression of human immunodeficiency virus Nef in specific immune cell populations of transgenic mice is associated with distinct AIDS-like phenotypes.
Hanna Z, Priceputu E, Chrobak P, Hu C, Dugas V, Goupil M, Marquis M, de Repentigny L, Jolicoeur P
J Virol. 2009
PubMed ID: 19605470
FOXP3 expression in hepatitis C virus-specific CD4+ T cells during acute hepatitis C.
Heeg MH, Ulsenheimer A, Grüner NH, Zachoval R, Jung MC, Gerlach JT, Raziorrouh B, Schraut W, Horster S, Kauke T, Spannagl M, Diepolder HM
Gastroenterology. 2009
PubMed ID: 19596013
Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.
Sarafova SD, Van Laethem F, Adoro S, Guinter T, Sharrow SO, Feigenbaum L, Singer A
Immunity. 2009
PubMed ID: 19747858
Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells.
Cao Z, Wara AK, Icli B, Sun X, Packard RR, Esen F, Stapleton CJ, Subramaniam M, Kretschmer K, Apostolou I, von Boehmer H, Hansson GK, Spelsberg TC, Libby P, Feinberg MW
J Biol Chem. 2009
PubMed ID: 19602726
T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling.
Terauchi M, Li JY, Bedi B, Baek KH, Tawfeek H, Galley S, Gilbert L, Nanes MS, Zayzafoon M, Guldberg R, Lamar DL, Singer MA, Lane TF, Kronenberg HM, Weitzmann MN, Pacifici R
Cell Metab. 2009
PubMed ID: 19723499
Tolerogenic semimature dendritic cells induce effector T-cell hyporesponsiveness by the activation of antigen-specific CD4+ CD25+ T-regulatory cells.
Fu BM, He XS, Yu S, Hu AB, Ma Y, Wu LW, Tam NL, Huang JF
Exp Clin Transplant. 2009
PubMed ID: 19715524
CD4-CD8 lineage differentiation: Thpok-ing into the nucleus.
Wang L, Bosselut R
J Immunol. 2009
PubMed ID: 19696430
Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury.
Venet F, Chung CS, Huang X, Lomas-Neira J, Chen Y, Ayala A
J Immunol. 2009
PubMed ID: 19641139
Differential effects of dendritic cell transfer on airway hyperresponsiveness and inflammation.
Koya T, Matsuda H, Matsubara S, Miyahara N, Dakhama A, Takeda K, Gelfand EW
Am J Respir Cell Mol Biol. 2009
PubMed ID: 19151321
Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon.
Greenwell-Wild T, Vázquez N, Jin W, Rangel Z, Munson PJ, Wahl SM
Blood. 2009
PubMed ID: 19556424
CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2.
Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, Yamamoto K
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19666526
Increased interleukin-10 production without expansion of CD4+CD25+ T-regulatory cells in early stable renal transplant patients on calcineurin inhibitors.
Mittal SK, Sharma RK, Gupta A, Naik S
Transplantation. 2009
PubMed ID: 19667950
Extracorporeal photophoresis augments function of CD4+CD25+FoxP3+ regulatory T cells by triggering adenosine production.
Schmitt S, Johnson TS, Karakhanova S, Näher H, Mahnke K, Enk AH
Transplantation. 2009
PubMed ID: 19667946
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.
DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N, Coussens LM
Cancer Cell. 2009
PubMed ID: 19647220
[Altered frequency of CD4+CD25-Foxp3+ T cells in patients with systemic lupus erythematosus]
Yan B, Liu Y, Xie QB, Liu G
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009
PubMed ID: 19664391
Common genetic variants in candidate genes and risk of familial lymphoid malignancies.
Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR
Br J Haematol. 2009
PubMed ID: 19573080
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.
Guarda G, Dostert C, Staehli F, Cabalzar K, Castillo R, Tardivel A, Schneider P, Tschopp J
Nature. 2009
PubMed ID: 19494813
Nef-induced CD4 endocytosis in human immunodeficiency virus type 1 host cells: role of p56lck kinase.
Laguette N, Brégnard C, Bouchet J, Benmerah A, Benichou S, Basmaciogullari S
J Virol. 2009
PubMed ID: 19439470
Glycosyltransferase function in core 2-type protein O glycosylation.
Stone EL, Ismail MN, Lee SH, Luu Y, Ramirez K, Haslam SM, Ho SB, Dell A, Fukuda M, Marth JD
Mol Cell Biol. 2009
PubMed ID: 19349303
Local effector failure in mesothelioma is not mediated by CD4+ CD25+ T-regulator cells.
Jackaman C, Cornwall S, Lew AM, Zhan Y, Robinson BW, Nelson DJ
Eur Respir J. 2009
PubMed ID: 19251786
Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.
Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH, Sayegh MH
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19528638
A vital role for interleukin-21 in the control of a chronic viral infection.
Yi JS, Du M, Zajac AJ
Science. 2009
PubMed ID: 19443735
Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii.
Schaeffer M, Han SJ, Chtanova T, van Dooren GG, Herzmark P, Chen Y, Roysam B, Striepen B, Robey EA
J Immunol. 2009
PubMed ID: 19414791
CD8 T cells producing IL-17 and IFN-gamma initiate the innate immune response required for responses to antigen skin challenge.
Kish DD, Li X, Fairchild RL
J Immunol. 2009
PubMed ID: 19414746
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen.
Vondenhoff MF, Greuter M, Goverse G, Elewaut D, Dewint P, Ware CF, Hoorweg K, Kraal G, Mebius RE
J Immunol. 2009
PubMed ID: 19380791
A common CD4 gene variant is associated with an increased risk of HIV-1 infection in Kenyan female commercial sex workers.
Oyugi JO, Vouriot FC, Alimonti J, Wayne S, Luo M, Land AM, Ao Z, Yao X, Sekaly RP, Elliott LJ, Simonsen JN, Ball TB, Jaoko W, Kimani J, Plummer FA, Fowke KR
J Infect Dis. 2009
PubMed ID: 19301975
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
CD4 microglial expression correlates with spontaneous clinical improvement in the acute Lewis rat EAE model.
Almolda B, Costa M, Montoya M, González B, Castellano B
J Neuroimmunol. 2009
PubMed ID: 19246105
Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus.
Dai Z, Turtle CJ, Booth GC, Riddell SR, Gooley TA, Stevens AM, Spies T, Groh V
J Exp Med. 2009
PubMed ID: 19289577
Reciprocal modulation of circulating CD4+CD25+bright T cells induced by extracorporeal photochemotherapy in cutaneous T-cell lymphoma and chronic graft-versus-host-disease patients.
Quaglino P, Comessatti A, Ponti R, Peroni A, Mola F, Fierro MT, Savoia P, Novelli M, Bernengo MG
Int J Immunopathol Pharmacol. 2009
PubMed ID: 19505389
Analysis of different staining techniques for c4d detection in renal allograft biopsies.
Ludovico-Martins H, Silva C, Teodoro WR, Martini Filho D, Noronha IL
Transplant Proc. 2009
PubMed ID: 19376373
Focal C4d+ in renal allografts is associated with the presence of donor-specific antibodies and decreased allograft survival.
Kedainis RL, Koch MJ, Brennan DC, Liapis H
Am J Transplant. 2009
PubMed ID: 19344468
Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development.
Sultana DA, Tomita S, Hamada M, Iwanaga Y, Kitahama Y, Khang NV, Hirai S, Ohigashi I, Nitta S, Amagai T, Takahashi S, Takahama Y
Blood. 2009
PubMed ID: 19164599
HIV-1 binding to CD4 on CD4+CD25+ regulatory T cells enhances their suppressive function and induces them to home to, and accumulate in, peripheral and mucosal lymphoid tissues: an additional mechanism of immunosuppression.
Ji J, Cloyd MW
Int Immunol. 2009
PubMed ID: 19208751
Frequency of Foxp3+CD4CD25+ T cells is associated with the phenotypes of allergic asthma.
Matsumoto K, Inoue H, Fukuyama S, Kan-O K, Eguchi-Tsuda M, Matsumoto T, Moriwaki A, Nakano T, Nakanishi Y
Respirology. 2009
PubMed ID: 19192224
A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex.
Chaudhuri R, Mattera R, Lindwasser OW, Robinson MS, Bonifacino JS
J Virol. 2009
PubMed ID: 19129443
CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface.
Achour L, Scott MG, Shirvani H, Thuret A, Bismuth G, Labbé-Jullié C, Marullo S
Blood. 2009
PubMed ID: 19064722
Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5.
Madan V, Madan B, Brykczynska U, Zilbermann F, Hogeveen K, Döhner K, Döhner H, Weber O, Blum C, Rodewald HR, Sassone-Corsi P, Peters AH, Fehling HJ
Blood. 2009
PubMed ID: 18952892
Molecular basis of CD4 repression by the Swi/Snf-like BAF chromatin remodeling complex.
Wan M, Zhang J, Lai D, Jani A, Prestone-Hurlburt P, Zhao L, Ramachandran A, Schnitzler GR, Chi T
Eur J Immunol. 2009
PubMed ID: 19180471
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H
J Proteome Res. 2009
PubMed ID: 19159218
Combinational Polymorphisms of Seven CXCL12-Related Genes Are Protective against Breast Cancer in Taiwan.
Lin GT, Tseng HF, Yang CH, Hou MF, Chuang LY, Tai HT, Tai MH, Cheng YH, Wen CH, Liu CS, Huang CJ, Wang CL, Chang HW
OMICS. 2009
PubMed ID: 19196101
Tumor-shed PGE(2) impairs IL2Rgammac-signaling to inhibit CD4 T cell survival: regulation by theaflavins.
Chattopadhyay S, Bhattacharyya S, Saha B, Chakraborty J, Mohanty S, Sakib Hossain DM, Banerjee S, Das K, Sa G, Das T
PLoS One. 2009
PubMed ID: 19812686
Non-redundant role for IL-12 and IL-27 in modulating Th2 polarization of carcinoembryonic antigen specific CD4 T cells from pancreatic cancer patients.
Tassi E, Braga M, Longhi R, Gavazzi F, Parmiani G, Di Carlo V, Protti MP
PLoS One. 2009
PubMed ID: 19798410
miR-155 inhibition sensitizes CD4+ Th cells for TREG mediated suppression.
Stahl HF, Fauti T, Ullrich N, Bopp T, Kubach J, Rust W, Labhart P, Alexiadis V, Becker C, Hafner M, Weith A, Lenter MC, Jonuleit H, Schmitt E, Mennerich D
PLoS One. 2009
PubMed ID: 19777054
Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking.
Kim JK, Klinger M, Benjamin J, Xiao Y, Erle DJ, Littman DR, Killeen N
PLoS One. 2009
PubMed ID: 19668367
Helicobacter pylori increases expression of proapoptotic markers Fas and FasL on CD4 lymphocytes in children.
Kotłowska-Kmieć A, Bakowska A, Szarszewski A, Kamińska B, Łuczak G, Radys W, Landowski P, Brodzicki J, Korzon M, Liberek A
Acta Biochim Pol. 2009
PubMed ID: 19572057
Differential role of autophagy in CD4 T cells and macrophages during X4 and R5 HIV-1 infection.
Espert L, Varbanov M, Robert-Hebmann V, Sagnier S, Robbins I, Sanchez F, Lafont V, Biard-Piechaczyk M
PLoS One. 2009
PubMed ID: 19492063
The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane.
Py B, Basmaciogullari S, Bouchet J, Zarka M, Moura IC, Benhamou M, Monteiro RC, Hocini H, Madrid R, Benichou S
PLoS One. 2009
PubMed ID: 19333378
Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.
Brochard V, Combadière B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D, Callebert J, Launay JM, Duyckaerts C, Flavell RA, Hirsch EC, Hunot S
J Clin Invest. 2009
PubMed ID: 19104149
Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes.
Barrero-Villar M, Cabrero JR, Gordón-Alonso M, Barroso-González J, Alvarez-Losada S, Muñoz-Fernández MA, Sánchez-Madrid F, Valenzuela-Fernández A
J Cell Sci. 2009
PubMed ID: 19066282
Lymph sacs are not required for the initiation of lymph node formation.
Vondenhoff MF, van de Pavert SA, Dillard ME, Greuter M, Goverse G, Oliver G, Mebius RE
Development. 2009
PubMed ID: 19060331
Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice.
Yu S, Bruce D, Froicu M, Weaver V, Cantorna MT
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19095793
Hepatic stellate cells preferentially expand allogeneic CD4+ CD25+ FoxP3+ regulatory T cells in an IL-2-dependent manner.
Jiang G, Yang HR, Wang L, Wildey GM, Fung J, Qian S, Lu L
Transplantation. 2008
PubMed ID: 19077880
Regulated movement of CD4 in and out of the immunological synapse.
Kao H, Lin J, Littman DR, Shaw AS, Allen PM
J Immunol. 2008
PubMed ID: 19050241
T cell-independent spontaneous loss of tolerance by anti-double-stranded DNA B cells in C57BL/6 mice.
Tsao PY, Jiao J, Ji MQ, Cohen PL, Eisenberg RA
J Immunol. 2008
PubMed ID: 19017966
Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus.
Abe J, Ueha S, Suzuki J, Tokano Y, Matsushima K, Ishikawa S
Am J Pathol. 2008
PubMed ID: 19008373
A novel genetic strategy reveals unexpected roles of the Swi-Snf-like chromatin-remodeling BAF complex in thymocyte development.
Jani A, Wan M, Zhang J, Cui K, Wu J, Preston-Hurlburt P, Khatri R, Zhao K, Chi T
J Exp Med. 2008
PubMed ID: 18955569
Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic.
Adoro S, Erman B, Sarafova SD, Van Laethem F, Park JH, Feigenbaum L, Singer A
J Immunol. 2008
PubMed ID: 18981117
Association of CD4 enhancer gene polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Taiwan.
Lo SF, Wan L, Lin HC, Huang CM, Tsai FJ
J Rheumatol. 2008
PubMed ID: 19004052
The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo.
Vukmanovic-Stejic M, Agius E, Booth N, Dunne PJ, Lacy KE, Reed JR, Sobande TO, Kissane S, Salmon M, Rustin MH, Akbar AN
J Clin Invest. 2008
PubMed ID: 18924611
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.
Shiow LR, Roadcap DW, Paris K, Watson SR, Grigorova IL, Lebet T, An J, Xu Y, Jenne CN, Föger N, Sorensen RU, Goodnow CC, Bear JE, Puck JM, Cyster JG
Nat Immunol. 2008
PubMed ID: 18836449
Depletion of CD4(+)CD25(+) regulatory T cells can promote local immunity to suppress tumor growth in benzo[a]pyrene-induced forestomach carcinoma.
Chen YL, Fang JH, Lai MD, Shan YS
World J Gastroenterol. 2008
PubMed ID: 18855977
Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate.
Muroi S, Naoe Y, Miyamoto C, Akiyama K, Ikawa T, Masuda K, Kawamoto H, Taniuchi I
Nat Immunol. 2008
PubMed ID: 18776907
Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells.
Wang L, Wildt KF, Zhu J, Zhang X, Feigenbaum L, Tessarollo L, Paul WE, Fowlkes BJ, Bosselut R
Nat Immunol. 2008
PubMed ID: 18776904
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency.
Mott KR, Underhill D, Wechsler SL, Ghiasi H
J Virol. 2008
PubMed ID: 18667491
SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation.
Kamperschroer C, Roberts DM, Zhang Y, Weng NP, Swain SL
J Immunol. 2008
PubMed ID: 18768854
siRNA stabilization prolongs gene knockdown in primary T lymphocytes.
Mantei A, Rutz S, Janke M, Kirchhoff D, Jung U, Patzel V, Vogel U, Rudel T, Andreou I, Weber M, Scheffold A
Eur J Immunol. 2008
PubMed ID: 18792414
Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development.
Lavine KJ, Long F, Choi K, Smith C, Ornitz DM
Development. 2008
PubMed ID: 18725519
CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner.
Andersson J, Tran DQ, Pesu M, Davidson TS, Ramsey H, O'Shea JJ, Shevach EM
J Exp Med. 2008
PubMed ID: 18710931
SCART scavenger receptors identify a novel subset of adult gammadelta T cells.
Kisielow J, Kopf M, Karjalainen K
J Immunol. 2008
PubMed ID: 18641307
C4d deposition and cellular infiltrates as markers of acute rejection in rat models of orthotopic lung transplantation.
Murata K, Iwata T, Nakashima S, Fox-Talbot K, Qian Z, Wilkes DS, Baldwin WM
Transplantation. 2008
PubMed ID: 18622289
CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis.
Mills JH, Thompson LF, Mueller C, Waickman AT, Jalkanen S, Niemela J, Airas L, Bynoe MS
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18591671
Separation of splenic red and white pulp occurs before birth in a LTalphabeta-independent manner.
Vondenhoff MF, Desanti GE, Cupedo T, Bertrand JY, Cumano A, Kraal G, Mebius RE, Golub R
J Leukoc Biol. 2008
PubMed ID: 18403646
Impaired function of CD4+/CD25+ T regulatory lymphocytes characterizes the self-limited hepatitis A virus infection.
Perrella A, Vitiello L, Atripaldi L, Sbreglia C, Grattacaso S, Bellopede P, Patarino T, Morelli G, Altamura S, Racioppi L, Perrella O
J Gastroenterol Hepatol. 2008
PubMed ID: 17645467
Anti-CD4-mediated selection of Treg in vitro - in vitro suppression does not predict in vivo capacity to prevent graft rejection.
Oliveira V, Sawitzki B, Chapman S, Appelt C, Gebuhr I, Wieckiewicz J, Long E, Wood KJ
Eur J Immunol. 2008
PubMed ID: 18465768
CD4+ T lymphocytes mediate hypercholesterolemia-induced endothelial dysfunction via a NAD(P)H oxidase-dependent mechanism.
Wolfort RM, Stokes KY, Granger DN
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 18408127
An alteration of human immunodeficiency virus gp41 leads to reduced CCR5 dependence and CD4 independence.
Taylor BM, Foulke JS, Flinko R, Heredia A, DeVico A, Reitz M
J Virol. 2008
PubMed ID: 18353949
Antagonistic roles of CD4+ and CD8+ T-cells in 7,12-dimethylbenz(a)anthracene cutaneous carcinogenesis.
Yusuf N, Nasti TH, Katiyar SK, Jacobs MK, Seibert MD, Ginsburg AC, Timares L, Xu H, Elmets CA
Cancer Res. 2008
PubMed ID: 18483278
Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection.
Sun K, Metzger DW
Nat Med. 2008
PubMed ID: 18438414
Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes.
Wang T, Chen L, Ahmed E, Ma L, Yin D, Zhou P, Shen J, Xu H, Wang CR, Alegre ML, Chong AS
J Immunol. 2008
PubMed ID: 18424719
Aerobic training increases the stimulated percentage of CD4+CD25+ in older men but not older women.
Broadbent S, Gass G
Eur J Appl Physiol. 2008
PubMed ID: 18204854
CD4-expressing cells are early mediators of the innate immune system during sepsis.
Martignoni A, Tschöp J, Goetzman HS, Choi LG, Reid MD, Johannigman JA, Lentsch AB, Caldwell CC
Shock. 2008
PubMed ID: 17885647
Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation.
Kathrein KL, Chari S, Winandy S
J Biol Chem. 2008
PubMed ID: 18287091
CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H.
Bloom DD, Chang Z, Fechner JH, Dar W, Polster SP, Pascual J, Turka LA, Knechtle SJ
Am J Transplant. 2008
PubMed ID: 18261176
Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development.
Yu M, Wan M, Zhang J, Wu J, Khatri R, Chi T
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18322012
Circulating naïve and CD4+CD25high regulatory T cells in patients with autoimmune pancreatitis.
Miyoshi H, Uchida K, Taniguchi T, Yazumi S, Matsushita M, Takaoka M, Okazaki K
Pancreas. 2008
PubMed ID: 18376303
CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus.
He X, Park K, Wang H, He X, Zhang Y, Hua X, Li Y, Kappes DJ
Immunity. 2008
PubMed ID: 18342007
Toward an atomistic understanding of the immune synapse: large-scale molecular dynamics simulation of a membrane-embedded TCR-pMHC-CD4 complex.
Wan S, Flower DR, Coveney PV
Mol Immunol. 2008
PubMed ID: 17980430
Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients.
Yang H, Qiu L, Chen G, Ye Z, Lü C, Lin Q
Fertil Steril. 2008
PubMed ID: 17543960
CD4+CD25+ regulatory T cells selectively diminish systemic autoreactivity in arthritic K/BxN mice.
Kang SM, Jang E, Paik DJ, Jang YJ, Youn J
Mol Cells. 2008
PubMed ID: 18319615
CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain.
Cao L, DeLeo JA
Eur J Immunol. 2008
PubMed ID: 18196515
Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis.
Strid J, Roberts SJ, Filler RB, Lewis JM, Kwong BY, Schpero W, Kaplan DH, Hayday AC, Girardi M
Nat Immunol. 2008
PubMed ID: 18176566
Structural basis for the interaction between focal adhesion kinase and CD4.
Garron ML, Arthos J, Guichou JF, McNally J, Cicala C, Arold ST
J Mol Biol. 2008
PubMed ID: 18078954
Conformational rearrangement within the soluble domains of the CD4 receptor is ligand-specific.
Ashish, Juncadella IJ, Garg R, Boone CD, Anguita J, Krueger JK
J Biol Chem. 2008
PubMed ID: 18045872
Differential chromatin looping regulates CD4 expression in immature thymocytes.
Jiang H, Peterlin BM
Mol Cell Biol. 2008
PubMed ID: 18039856
Hepatitis B vaccine-specific CD4(+) T cells can be detected and characterised at the single cell level: limited usefulness of dendritic cells as signal enhancers.
Litjens NH, Huisman M, Baan CC, van Druningen CJ, Betjes MG
J Immunol Methods. 2008
PubMed ID: 18061610
A new T-cell receptor transgenic model of the CD4+ direct pathway: level of priming determines acute versus chronic rejection.
Brennan TV, Hoang V, Garrod KR, Liu FC, Hayden T, Kim J, Kang SM
Transplantation. 2008
PubMed ID: 18212630
Identification of CD4(-)CD8(-) double-negative natural killer T cell precursors in the thymus.
Dashtsoodol N, Watarai H, Sakata S, Taniguchi M
PLoS ONE. 2008
PubMed ID: 18997862
Correlation between CD4 counts of HIV patients and enteric protozoan in different seasons - an experience of a tertiary care hospital in Varanasi (India).
Tuli L, Gulati AK, Sundar S, Mohapatra TM
BMC Gastroenterol. 2008
PubMed ID: 18713475
Alloreactivity of ex vivo-expanded T cells is correlated with expansion and CD4/CD8 ratio.
Mercier-Letondal P, Montcuquet N, Sauce D, Certoux JM, Jeanningros S, Ferrand C, Bonyhadi M, Tiberghien P, Robinet E
Cytotherapy. 2008
PubMed ID: 18418773
HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4.
Puigdomènech I, Massanella M, Izquierdo-Useros N, Ruiz-Hernandez R, Curriu M, Bofill M, Martinez-Picado J, Juan M, Clotet B, Blanco J
Retrovirology. 2008
PubMed ID: 18377648
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.
Tzartos JS, Friese MA, Craner MJ, Palace J, Newcombe J, Esiri MM, Fugger L
Am J Pathol. 2008
PubMed ID: 18156204
Restricted lateral mobility of plasma membrane CD4 impairs HIV-1 envelope glycoprotein mediated fusion.
Rawat SS, Zimmerman C, Johnson BT, Cho E, Lockett SJ, Blumenthal R, Puri A
Mol Membr Biol. 2008
PubMed ID: 18097956
Decreased CD4+CD25+bright T cells in peripheral blood of patients with primary Sjogren's syndrome.
Liu MF, Lin LH, Weng CT, Weng MY
Lupus. 2008
PubMed ID: 18089681
Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes.
Joffre O, Santolaria T, Calise D, Al Saati T, Hudrisier D, Romagnoli P, van Meerwijk JP
Nat Med. 2008
PubMed ID: 18066074
In vivo imaging of mucosal CD4+ T cells using single photon emission computed tomography in a murine model of colitis.
Kanwar B, Gao DW, Hwang AB, Grenert JP, Williams SP, Franc B, McCune JM
J Immunol Methods. 2008
PubMed ID: 17964595
Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier.
Sevilla LM, Nachat R, Groot KR, Klement JF, Uitto J, Djian P, Määttä A, Watt FM
J Cell Biol. 2007
PubMed ID: 18166659
CD4 T cells are required for CD8 T cell survival during both primary and memory recall responses.
Novy P, Quigley M, Huang X, Yang Y
J Immunol. 2007
PubMed ID: 18056368
Structural characterization of the transmembrane and cytoplasmic domains of human CD4.
Wittlich M, Koenig BW, Hoffmann S, Willbold D
Biochim Biophys Acta. 2007
PubMed ID: 18035040
CD4 T cells activated in the mesenteric lymph node mediate gastrointestinal food allergy in mice.
Knight AK, Blázquez AB, Zhang S, Mayer L, Sampson HA, Berin MC
Am J Physiol Gastrointest Liver Physiol. 2007
PubMed ID: 17916645
Modulation of CD1d-restricted NKT cell responses by CD4.
Chen X, Wang X, Besra GS, Gumperz JE
J Leukoc Biol. 2007
PubMed ID: 17726154
Human bullous pemphigoid antigen 2 transgenic skin elicits specific IgG in wild-type mice.
Olasz EB, Roh J, Yee CL, Arita K, Akiyama M, Shimizu H, Vogel JC, Yancey KB
J Invest Dermatol. 2007
PubMed ID: 17657247
CD4 interacts constitutively with multiple CCR5 at the plasma membrane of living cells. A fluorescence recovery after photobleaching at variable radii approach.
Baker AM, Saulière A, Gaibelet G, Lagane B, Mazères S, Fourage M, Bachelerie F, Salomé L, Lopez A, Dumas F
J Biol Chem. 2007
PubMed ID: 17855336
Profiling of the CD4 receptor complex proteins.
Krotov GI, Krutikova MP, Zgoda VG, Filatov AV
Biochemistry (Mosc). 2007
PubMed ID: 18205604
Sequence variation occurs in CD4 epitopes during early HIV infection.
Rychert J, Saindon S, Placek S, Daskalakis D, Rosenberg E
J Acquir Immune Defic Syndr. 2007
PubMed ID: 18167642
Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.
Van Laethem F, Sarafova SD, Park JH, Tai X, Pobezinsky L, Guinter TI, Adoro S, Adams A, Sharrow SO, Feigenbaum L, Singer A
Immunity. 2007
PubMed ID: 18023370
Extralymphatic virus sanctuaries as a consequence of potent T-cell activation.
Recher M, Lang KS, Navarini A, Hunziker L, Lang PA, Fink K, Freigang S, Georgiev P, Hangartner L, Zellweger R, Bergthaler A, Hegazy AN, Eschli B, Theocharides A, Jeker LT, Merkler D, Odermatt B, Hersberger M, Hengartner H, Zinkernagel RM
Nat Med. 2007
PubMed ID: 17982463
Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression.
Naito T, Gómez-Del Arco P, Williams CJ, Georgopoulos K
Immunity. 2007
PubMed ID: 17980631
The frequency and suppressor function of CD4+CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neck.
Strauss L, Bergmann C, Gooding W, Johnson JT, Whiteside TL
Clin Cancer Res. 2007
PubMed ID: 17975141
Internalization and intracellular retention of CD4 are two separate functions of the human immunodeficiency virus type 1 Nef protein.
Giolo G, Neri F, Casartelli N, Potestà M, Belleudi F, Torrisi MR, Doria M
J Gen Virol. 2007
PubMed ID: 17947540
Antibodies to CD4-induced sites in HIV gp120 correlate with the control of SHIV challenge in macaques vaccinated with subunit immunogens.
DeVico A, Fouts T, Lewis GK, Gallo RC, Godfrey K, Charurat M, Harris I, Galmin L, Pal R
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17956985
Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia.
Grayson MH, Cheung D, Rohlfing MM, Kitchens R, Spiegel DE, Tucker J, Battaile JT, Alevy Y, Yan L, Agapov E, Kim EY, Holtzman MJ
J Exp Med. 2007
PubMed ID: 17954569
Defective alloreactive CD8 T cell function and memory response in allograft recipients in the absence of CD4 help.
Zhai Y, Wang Y, Wu Z, Kupiec-Weglinski JW
J Immunol. 2007
PubMed ID: 17878349
The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer.
Wildt KF, Sun G, Grueter B, Fischer M, Zamisch M, Ehlers M, Bosselut R
J Immunol. 2007
PubMed ID: 17878336
'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.
Park JH, Adoro S, Lucas PJ, Sarafova SD, Alag AS, Doan LL, Erman B, Liu X, Ellmeier W, Bosselut R, Feigenbaum L, Singer A
Nat Immunol. 2007
PubMed ID: 17873878
T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection.
Bitsaktsis C, Nandi B, Racine R, MacNamara KC, Winslow G
Infect Immun. 2007
PubMed ID: 17664264
The Siva protein is a novel intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells.
Py B, Bouchet J, Jacquot G, Sol-Foulon N, Basmaciogullari S, Schwartz O, Biard-Piechaczyk M, Benichou S
Apoptosis. 2007
PubMed ID: 17653867
Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells.
Intlekofer AM, Takemoto N, Kao C, Banerjee A, Schambach F, Northrop JK, Shen H, Wherry EJ, Reiner SL
J Exp Med. 2007
PubMed ID: 17698591
The Foxn1-dependent transcripts PCOLCE2 and mPPP1R16B are not required for normal thymopoiesis.
Heinzel K, Bleul CC
Eur J Immunol. 2007
PubMed ID: 17683113
MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids.
Morokuma Y, Nakamura N, Kato A, Notoya M, Yamamoto Y, Sakai Y, Fukuda H, Yamashina S, Hirata Y, Hirose S
J Biol Chem. 2007
PubMed ID: 17604280
Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells.
Sapoznikov A, Fischer JA, Zaft T, Krauthgamer R, Dzionek A, Jung S
J Exp Med. 2007
PubMed ID: 17646404
Bidirectional membrane molecule transfer between dendritic and T cells.
He T, Tang C, Liu Y, Ye Z, Wu X, Wei Y, Moyana T, Xiang J
Biochem Biophys Res Commun. 2007
PubMed ID: 17540342
Keeping the (kinase) party going: SLP-76 and ITK dance to the beat.
Qi Q, August A
Sci STKE. 2007
PubMed ID: 17652306
Expansion and tissue infiltration of an allospecific CD4+CD25+CD45RO+IL-7Ralphahigh cell population in solid organ transplant recipients.
Codarri L, Vallotton L, Ciuffreda D, Venetz JP, Garcia M, Hadaya K, Buhler L, Rotman S, Pascual M, Pantaleo G
J Exp Med. 2007
PubMed ID: 17591854
CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells.
Thedrez A, de Lalla C, Allain S, Zaccagnino L, Sidobre S, Garavaglia C, Borsellino G, Dellabona P, Bonneville M, Scotet E, Casorati G
Blood. 2007
PubMed ID: 17363727
Critical role of Arg59 in the high-affinity gp120-binding region of CD4 for human immunodeficiency virus type 1 infection.
Fontenot D, Jones JK, Hossain MM, Nehete PN, Vela EM, Dwyer VA, Jagannadha Sastry K
Virology. 2007
PubMed ID: 17320923
CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice.
Maeno T, Houghton AM, Quintero PA, Grumelli S, Owen CA, Shapiro SD
J Immunol. 2007
PubMed ID: 17548647
Human CD4+CD25+ regulatory T cells inhibit the differentiation of osteoclasts from peripheral blood mononuclear cells.
Kim YG, Lee CK, Nah SS, Mun SH, Yoo B, Moon HB
Biochem Biophys Res Commun. 2007
PubMed ID: 17462597
Killer cell Ig-like receptors CD158a and CD158b display a coactivatory function, involving the c-Jun NH2-terminal protein kinase signaling pathway, when expressed on malignant CD4+ T cells from a patient with Sezary syndrome.
Marie-Cardine A, Huet D, Ortonne N, Remtoula N, Le Gouvello S, Bagot M, Bensussan A
Blood. 2007
PubMed ID: 17522341
Mice lacking components of adaptive immunity show increased Brucella abortus virB mutant colonization.
Rolán HG, Tsolis RM
Infect Immun. 2007
PubMed ID: 17420243
Association of CD44 V3-containing isoforms with tumor cell growth, migration, matrix metalloproteinase expression, and lymph node metastasis in head and neck cancer.
Wang SJ, Wreesmann VB, Bourguignon LY
Head Neck. 2007
PubMed ID: 17252589
Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells.
Meier D, Bornmann C, Chappaz S, Schmutz S, Otten LA, Ceredig R, Acha-Orbea H, Finke D
Immunity. 2007
PubMed ID: 17521585
Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model.
Khiong K, Murakami M, Kitabayashi C, Ueda N, Sawa S, Sakamoto A, Kotzin BL, Rozzo SJ, Ishihara K, Verella-Garcia M, Kappler J, Marrack P, Hirano T
J Clin Invest. 2007
PubMed ID: 17476359
HIV envelope protein gp120-triggered CD4+ T-cell adhesion to vascular endothelium is regulated via CD4 and CXCR4 receptors.
Takano Y, Shimokado K, Hata Y, Yoshida M
Biochim Biophys Acta. 2007
PubMed ID: 17346946
CD4+ CD25+ regulatory T cells suppress CD4+ T-cell function and inhibit the development of Plasmodium berghei-specific TH1 responses involved in cerebral malaria pathogenesis.
Nie CQ, Bernard NJ, Schofield L, Hansen DS
Infect Immun. 2007
PubMed ID: 17325053
Gamma interferon responses of CD4 and CD8 T-cell subsets are quantitatively different and independent of each other during pulmonary Mycobacterium bovis BCG infection.
Ngai P, McCormick S, Small C, Zhang X, Zganiacz A, Aoki N, Xing Z
Infect Immun. 2007
PubMed ID: 17307945
Specific recruitment of CD4+CD25++ regulatory T cells into the allograft in heart transplant recipients.
Schmidt-Lucke C, Aicher A, Romagnani P, Gareis B, Romagnani S, Zeiher AM, Dimmeler S
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17237241
FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection.
Wilson TJ, Presti RM, Tassi I, Overton ET, Cella M, Colonna M
Blood. 2007
PubMed ID: 17213291
Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis.
Roberts SJ, Ng BY, Filler RB, Lewis J, Glusac EJ, Hayday AC, Tigelaar RE, Girardi M
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17412837
HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells.
Boasso A, Herbeuval JP, Hardy AW, Anderson SA, Dolan MJ, Fuchs D, Shearer GM
Blood. 2007
PubMed ID: 17158233
GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development.
Ling KW, van Hamburg JP, de Bruijn MJ, Kurek D, Dingjan GM, Hendriks RW
Eur J Immunol. 2007
PubMed ID: 17357106
Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.
Chaudhuri R, Lindwasser OW, Smith WJ, Hurley JH, Bonifacino JS
J Virol. 2007
PubMed ID: 17267500
Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice.
Mishra A, Schlotman J, Wang M, Rothenberg ME
J Leukoc Biol. 2007
PubMed ID: 17194734
Alpha-defensins block the early steps of HIV-1 infection: interference with the binding of gp120 to CD4.
Furci L, Sironi F, Tolazzi M, Vassena L, Lusso P
Blood. 2007
PubMed ID: 17132727
Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion.
Thomas ER, Dunfee RL, Stanton J, Bogdan D, Taylor J, Kunstman K, Bell JE, Wolinsky SM, Gabuzda D
Virology. 2007
PubMed ID: 17084877
Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis.
Veiga-Fernandes H, Coles MC, Foster KE, Patel A, Williams A, Natarajan D, Barlow A, Pachnis V, Kioussis D
Nature. 2007
PubMed ID: 17322904
Capture of target cell membrane components via trogocytosis is triggered by a selected set of surface molecules on T or B cells.
Hudrisier D, Aucher A, Puaux AL, Bordier C, Joly E
J Immunol. 2007
PubMed ID: 17339461
The contribution of CD4+ CD25+ T-regulatory-cells to immune suppression in sepsis.
Wisnoski N, Chung CS, Chen Y, Huang X, Ayala A
Shock. 2007
PubMed ID: 17304105
CD4 coexpression regulates DC-SIGN-mediated transmission of human immunodeficiency virus type 1.
Wang JH, Janas AM, Olson WJ, KewalRamani VN, Wu L
J Virol. 2007
PubMed ID: 17151103
A human mutant CD4 molecule resistant to HIV-1 binding restores helper T-lymphocyte functions in murine CD4-deficient mice.
Kim DK, Tahara-Hanaoka S, Satoko TH, Shinohara N, Shinohara N, Nakauchi H
Exp Mol Med. 2007
PubMed ID: 17334223
CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable.
Agopian K, Wei BL, Garcia JV, Gabuzda D
Virology. 2007
PubMed ID: 16979207
Exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies.
Burrer R, Buchmeier MJ, Wolfe T, Ting JP, Feuer R, Iglesias A, von Herrath MG
Am J Pathol. 2007
PubMed ID: 17255324
Silencing of both beta-TrCP1 and HOS (beta-TrCP2) is required to suppress human immunodeficiency virus type 1 Vpu-mediated CD4 down-modulation.
Butticaz C, Michielin O, Wyniger J, Telenti A, Rothenberger S
J Virol. 2007
PubMed ID: 17121803
Physiological levels of virion-associated human immunodeficiency virus type 1 envelope induce coreceptor-dependent calcium flux.
Melar M, Ott DE, Hope TJ
J Virol. 2007
PubMed ID: 17121788
Absence of perforin expression confers axonal protection despite demyelination.
Howe CL, Adelson JD, Rodriguez M
Neurobiol Dis. 2007
PubMed ID: 17112732
Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine.
Derrick SC, Evering TH, Sambandamurthy VK, Jalapathy KV, Hsu T, Chen B, Chen M, Russell RG, Junqueira-Kipnis AP, Orme IM, Porcelli SA, Jacobs WR, Morris SL
Immunology. 2007
PubMed ID: 17076705
SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase.
McCausland MM, Yusuf I, Tran H, Ono N, Yanagi Y, Crotty S
J Immunol. 2007
PubMed ID: 17202343
Requirements for the selective degradation of CD4 receptor molecules by the human immunodeficiency virus type 1 Vpu protein in the endoplasmic reticulum.
Binette J, Dubé M, Mercier J, Halawani D, Latterich M, Cohen EA
Retrovirology. 2007
PubMed ID: 17937819
Reduced number and function of CD4+CD25highFoxP3+ regulatory T cells in patients with systemic lupus erythematosus.
Lyssuk EY, Torgashina AV, Soloviev SK, Nassonov EL, Bykovskaia SN
Adv Exp Med Biol. 2007
PubMed ID: 17712998
Modulation of CD4+ T cell-dependent specific cytotoxic CD8+ T cells differentiation and proliferation by the timing of increase in the pathogen load.
Tzelepis F, Persechini PM, Rodrigues MM
PLoS ONE. 2007
PubMed ID: 17460760
Detection of the status of tumour-infiltrating CD4+ T-cell subpopulations in squamous cell carcinoma of the head and neck (HNSCC) using real-time RT-PCR detection of CD4 mRNA.
Smerkolj S, Volavek M, Glavac D
Cell Mol Biol Lett. 2007
PubMed ID: 17235436
Viral interactions in human lymphoid tissue: Human herpesvirus 7 suppresses the replication of CCR5-tropic human immunodeficiency virus type 1 via CD4 modulation.
Lisco A, Grivel JC, Biancotto A, Vanpouille C, Origgi F, Malnati MS, Schols D, Lusso P, Margolis LB
J Virol. 2007
PubMed ID: 17065205
CCR5 interactions with the variable 3 loop of gp120.
Napier KB, Wang ZX, Peiper SC, Trent JO
J Mol Model. 2007
PubMed ID: 16721558
CD4 and CCR5 constitutively interact at the plasma membrane of living cells: a confocal fluorescence resonance energy transfer-based approach.
Gaibelet G, Planchenault T, Mazères S, Dumas F, Arenzana-Seisdedos F, Lopez A, Lagane B, Bachelerie F
J Biol Chem. 2006
PubMed ID: 17035237
Adoptive cell therapy using in vitro generated human CD4+ CD25+ regulatory t cells with indirect allospecificity to promote donor-specific transplantation tolerance.
Jiang S, Tsang J, Lechler RI
Transplant Proc. 2006
PubMed ID: 17175221
Presence of functional mouse regulatory CD4+CD25+T cells in xenogeneic neonatal porcine thymus-grafted athymic mice.
Sun Z, Zhao L, Wang H, Sun L, Yi H, Zhao Y
Am J Transplant. 2006
PubMed ID: 17062002
CD4+ T-cell responses are required for clearance of West Nile virus from the central nervous system.
Sitati EM, Diamond MS
J Virol. 2006
PubMed ID: 17035323
Synergistic inhibition of HIV-1 envelope-mediated membrane fusion by inhibitors targeting the N and C-terminal heptad repeats of gp41.
Gustchina E, Louis JM, Bewley CA, Clore GM
J Mol Biol. 2006
PubMed ID: 17010381
Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference.
Li CJ
J Cell Physiol. 2006
PubMed ID: 17001685
HIV gp120-induced interaction between CD4 and CCR5 requires cholesterol-rich microenvironments revealed by live cell fluorescence resonance energy transfer imaging.
Yi L, Fang J, Isik N, Chim J, Jin T
J Biol Chem. 2006
PubMed ID: 16963439
GATA-3 regulates the development and function of invariant NKT cells.
Kim PJ, Pai SY, Brigl M, Besra GS, Gumperz J, Ho IC
J Immunol. 2006
PubMed ID: 17082577
Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.
Erman B, Alag AS, Dahle O, van Laethem F, Sarafova SD, Guinter TI, Sharrow SO, Grinberg A, Love PE, Singer A
J Immunol. 2006
PubMed ID: 17082573
Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15.
Garg R, Juncadella IJ, Ramamoorthi N, Ashish, Ananthanarayanan SK, Thomas V, Rincón M, Krueger JK, Fikrig E, Yengo CM, Anguita J
J Immunol. 2006
PubMed ID: 17082567
The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS.
Quaranta MG, Mattioli B, Giordani L, Viora M
FASEB J. 2006
PubMed ID: 17077296
Interleukin-10 determines viral clearance or persistence in vivo.
Brooks DG, Trifilo MJ, Edelmann KH, Teyton L, McGavern DB, Oldstone MB
Nat Med. 2006
PubMed ID: 17041596
Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations.
Lundmark F, Harbo HF, Celius EG, Saarela J, Datta P, Oturai A, Lindgren CM, Masterman T, Salter H, Hillert J
J Neuroimmunol. 2006
PubMed ID: 17020785
Resistance profile of a neutralizing anti-HIV monoclonal antibody, KD-247, that shows favourable synergism with anti-CCR5 inhibitors.
Yoshimura K, Shibata J, Kimura T, Honda A, Maeda Y, Koito A, Murakami T, Mitsuya H, Matsushita S
AIDS. 2006
PubMed ID: 17053352
Dysregulation of IL-15-mediated T-cell homeostasis in TGF-beta dominant-negative receptor transgenic mice.
Lucas PJ, Kim SJ, Mackall CL, Telford WG, Chu YW, Hakim FT, Gress RE
Blood. 2006
PubMed ID: 16788095
Association between Nef-specific CD8 T-cell responses and disease progression in HIV-1 subtype B infection.
Jiao Y, Li TS, Xie J, Han Y, Qiu ZF, Zuo LY, Mourez T, Wang AX
Chin Med J (Engl). 2006
PubMed ID: 17042973
Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4+ T cells.
Naarding MA, Dirac AM, Ludwig IS, Speijer D, Lindquist S, Vestman EL, Stax MJ, Geijtenbeek TB, Pollakis G, Hernell O, Paxton WA
Antimicrob Agents Chemother. 2006
PubMed ID: 17005819
Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis.
Fukuyama S, Nagatake T, Kim DY, Takamura K, Park EJ, Kaisho T, Tanaka N, Kurono Y, Kiyono H
J Immunol. 2006
PubMed ID: 16982861
Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7.
Peffault de Latour R, Dujardin HC, Mishellany F, Burlen-Defranoux O, Zuber J, Marques R, Di Santo J, Cumano A, Vieira P, Bandeira A
Blood. 2006
PubMed ID: 16763207
CD4 expression on activated NK cells: ligation of CD4 induces cytokine expression and cell migration.
Bernstein HB, Plasterer MC, Schiff SE, Kitchen CM, Kitchen S, Zack JA
J Immunol. 2006
PubMed ID: 16951326
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
Marie JC, Liggitt D, Rudensky AY
Immunity. 2006
PubMed ID: 16973387
Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo.
Vukmanovic-Stejic M, Zhang Y, Cook JE, Fletcher JM, McQuaid A, Masters JE, Rustin MH, Taams LS, Beverley PC, Macallan DC, Akbar AN
J Clin Invest. 2006
PubMed ID: 16955142
PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs.
Walsh PT, Buckler JL, Zhang J, Gelman AE, Dalton NM, Taylor DK, Bensinger SJ, Hancock WW, Turka LA
J Clin Invest. 2006
PubMed ID: 16917540
Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs.
Wang Z, Hong J, Sun W, Xu G, Li N, Chen X, Liu A, Xu L, Sun B, Zhang JZ
J Clin Invest. 2006
PubMed ID: 16906223
An anti-CCR5 monoclonal antibody and small molecule CCR5 antagonists synergize by inhibiting different stages of human immunodeficiency virus type 1 entry.
Safarian D, Carnec X, Tsamis F, Kajumo F, Dragic T
Virology. 2006
PubMed ID: 16777164
HIV co-receptor inhibitors as novel class of anti-HIV drugs.
Schols D
Antiviral Res. 2006
PubMed ID: 16753228
Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes.
Ip CW, Kroner A, Bendszus M, Leder C, Kobsar I, Fischer S, Wiendl H, Nave KA, Martini R
J Neurosci. 2006
PubMed ID: 16885234
Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4.
Espert L, Denizot M, Grimaldi M, Robert-Hebmann V, Gay B, Varbanov M, Codogno P, Biard-Piechaczyk M
J Clin Invest. 2006
PubMed ID: 16886061
HIV and CXCR4 in a kiss of autophagic death.
Levine B, Sodora DL
J Clin Invest. 2006
PubMed ID: 16886053
CD8 T cells mediate transient herpes stromal keratitis in CD4-deficient mice.
Lepisto AJ, Frank GM, Xu M, Stuart PM, Hendricks RL
Invest Ophthalmol Vis Sci. 2006
PubMed ID: 16877409
Contribution of Vpu, Env, and Nef to CD4 down-modulation and resistance of human immunodeficiency virus type 1-infected T cells to superinfection.
Wildum S, Schindler M, Münch J, Kirchhoff F
J Virol. 2006
PubMed ID: 16873261
Induction of alphadelta- and alphabeta-mediated T cell responses in healthy elderly subjects after influenza vaccination.
Re F, Donnini A, Provinciali M
Biogerontology. 2006
PubMed ID: 16821115
Functional characterization of HIV-1 Nef mutants in the context of viral infection.
Fackler OT, Moris A, Tibroni N, Giese SI, Glass B, Schwartz O, Kräusslich HG
Virology. 2006
PubMed ID: 16684552
FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis.
Fujii R, Kanai T, Nemoto Y, Makita S, Oshima S, Okamoto R, Tsuchiya K, Totsuka T, Watanabe M
Am J Physiol Gastrointest Liver Physiol. 2006
PubMed ID: 16574986
Dominant-negative effect of hetero-oligomerization on the function of the human immunodeficiency virus type 1 envelope glycoprotein complex.
Herrera C, Klasse PJ, Kibler CW, Michael E, Moore JP, Beddows S
Virology. 2006
PubMed ID: 16616288
Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells.
Northrop JK, Thomas RM, Wells AD, Shen H
J Immunol. 2006
PubMed ID: 16818762
Role of protein disulfide isomerase and other thiol-reactive proteins in HIV-1 envelope protein-mediated fusion.
Ou W, Silver J
Virology. 2006
PubMed ID: 16507315
Chemokines and chemokine receptors in HIV infection: role in pathogenesis and therapeutics.
Suresh P, Wanchu A
J Postgrad Med. 2006
PubMed ID: 16855325
Defective virus drives human immunodeficiency virus infection, persistence, and pathogenesis.
Finzi D, Plaeger SF, Dieffenbach CW
Clin Vaccine Immunol. 2006
PubMed ID: 16829607
Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis.
Peters PJ, Sullivan WM, Duenas-Decamp MJ, Bhattacharya J, Ankghuambom C, Brown R, Luzuriaga K, Bell J, Simmonds P, Ball J, Clapham PR
J Virol. 2006
PubMed ID: 16775320
Levels of circulating regulatory CD4+CD25+ T cells are decreased in breast cancer patients after vaccination with a HER2/neu peptide (E75) and GM-CSF vaccine.
Hueman MT, Stojadinovic A, Storrer CE, Foley RJ, Gurney JM, Shriver CD, Ponniah S, Peoples GE
Breast Cancer Res Treat. 2006
PubMed ID: 16758122
Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells.
Sawa S, Kamimura D, Jin GH, Morikawa H, Kamon H, Nishihara M, Ishihara K, Murakami M, Hirano T
J Exp Med. 2006
PubMed ID: 16717113
Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck).
Marracci GH, Marquardt WE, Strehlow A, McKeon GP, Gross J, Buck DC, Kozell LB, Bourdette DN
Biochem Biophys Res Commun. 2006
PubMed ID: 16631599
An immunoglobulin fusion protein based on the gp120-CD4 receptor complex potently inhibits human immunodeficiency virus type 1 in vitro.
Vu JR, Fouts T, Bobb K, Burns J, McDermott B, Israel DI, Godfrey K, DeVico A
AIDS Res Hum Retroviruses. 2006
PubMed ID: 16796521
Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis.
Leithäuser F, Meinhardt-Krajina T, Fink K, Wotschke B, Möller P, Reimann J
Am J Pathol. 2006
PubMed ID: 16723705
Evidence for a domain-swapped CD4 dimer as the coreceptor for binding to class II MHC.
Maekawa A, Schmidt B, Fazekas de St Groth B, Sanejouand YH, Hogg PJ
J Immunol. 2006
PubMed ID: 16709847
Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells.
Liu H, Komai-Koma M, Xu D, Liew FY
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16632602
Characterization of CD4+ T cell responses in mice infected with Schistosoma japonicum.
Ji MJ, Su C, Wang Y, Wu HW, Cai XP, Li GF, Zhu X, Wang XJ, Zhang ZS, Wu GL
Acta Biochim Biophys Sin (Shanghai). 2006
PubMed ID: 16680373
Dynamics of CD4+CD25+ T cells in spleens and mesenteric lymph nodes of mice infected with Schistosoma japonicum.
Cai XP, Zhang H, Zhang YC, Wang Y, Su C, Ji MJ, Wu HW, Zhu X, Zhang ZS, Wu GL
Acta Biochim Biophys Sin (Shanghai). 2006
PubMed ID: 16680369
Triggering of T cell activation via CD4 dimers.
Moldovan MC, Sabbagh L, Breton G, Sékaly RP, Krummel MF
J Immunol. 2006
PubMed ID: 16622011
Transcriptional regulation of CD4 gene expression by T cell factor-1/beta-catenin pathway.
Huang Z, Xie H, Ioannidis V, Held W, Clevers H, Sadim MS, Sun Z
J Immunol. 2006
PubMed ID: 16585583
Evidence for a functional second thymus in mice.
Terszowski G, Müller SM, Bleul CC, Blum C, Schirmbeck R, Reimann J, Pasquier LD, Amagai T, Boehm T, Rodewald HR
Science. 2006
PubMed ID: 16513945
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Contribution of NK, NK T, gamma delta T, and alpha beta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi.
Sardinha LR, Elias RM, Mosca T, Bastos KR, Marinho CR, D'Império Lima MR, Alvarez JM
Infect Immun. 2006
PubMed ID: 16552032
Structural mimicry of CD4 by a cross-reactive HIV-1 neutralizing antibody with CDR-H2 and H3 containing unique motifs.
Prabakaran P, Gan J, Wu YQ, Zhang MY, Dimitrov DS, Ji X
J Mol Biol. 2006
PubMed ID: 16426633
The finished DNA sequence of human chromosome 12.
Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA, Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
Nature. 2006
PubMed ID: 16541075
Natural IgE production in the absence of MHC Class II cognate help.
McCoy KD, Harris NL, Diener P, Hatak S, Odermatt B, Hangartner L, Senn BM, Marsland BJ, Geuking MB, Hengartner H, Macpherson AJ, Zinkernagel RM
Immunity. 2006
PubMed ID: 16546101
Molecular basis of oligoubiquitin-dependent internalization of membrane proteins in Mammalian cells.
Barriere H, Nemes C, Lechardeur D, Khan-Mohammad M, Fruh K, Lukacs GL
Traffic. 2006
PubMed ID: 16497223
A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity.
Liu M, Chien CC, Burne-Taney M, Molls RR, Racusen LC, Colvin RB, Rabb H
J Am Soc Nephrol. 2006
PubMed ID: 16481417
Role of myristoylation and N-terminal basic residues in membrane association of the human immunodeficiency virus type 1 Nef protein.
Bentham M, Mazaleyrat S, Harris M
J Gen Virol. 2006
PubMed ID: 16476977
Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1.
Keppler OT, Tibroni N, Venzke S, Rauch S, Fackler OT
J Leukoc Biol. 2006
PubMed ID: 16365153
HIV-1 Nef mutations abrogating downregulation of CD4 affect other Nef functions and show reduced pathogenicity in transgenic mice.
Hanna Z, Priceputu E, Hu C, Vincent P, Jolicoeur P
Virology. 2006
PubMed ID: 16310238
HIV-1 tropism for the central nervous system: Brain-derived envelope glycoproteins with lower CD4 dependence and reduced sensitivity to a fusion inhibitor.
Martín-García J, Cao W, Varela-Rohena A, Plassmeyer ML, González-Scarano F
Virology. 2006
PubMed ID: 16309726
Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response.
Ramirez-Carrozzi VR, Nazarian AA, Li CC, Gore SL, Sridharan R, Imbalzano AN, Smale ST
Genes Dev. 2006
PubMed ID: 16452502
Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motif.
Coleman SH, Madrid R, Van Damme N, Mitchell RS, Bouchet J, Servant C, Pillai S, Benichou S, Guatelli JC
J Virol. 2006
PubMed ID: 16439540
Experimental African trypanosomiasis: a subset of pathogenic, IFN-gamma-producing, MHC class II-restricted CD4+ T cells mediates early mortality in highly susceptible mice.
Shi M, Wei G, Pan W, Tabel H
J Immunol. 2006
PubMed ID: 16424202
HIV-1 GP120 V3 conformational and informational entropies.
Weltman JK, Skowron G, Loriot GB
J Mol Model. 2006
PubMed ID: 16315040
Real-time analysis of human immunodeficiency virus type 1 Env-mediated membrane fusion by fluorescence resonance energy transfer.
Furuta RA, Nishikawa M, Fujisawa J
Microbes Infect. 2006
PubMed ID: 16300985
The role of cholesterol and sphingolipids in chemokine receptor function and HIV-1 envelope glycoprotein-mediated fusion.
Ablan S, Rawat SS, Viard M, Wang JM, Puri A, Blumenthal R
Virol J. 2006
PubMed ID: 17187670
Kinetic studies of HIV-1 and HIV-2 envelope glycoprotein-mediated fusion.
Gallo SA, Reeves JD, Garg H, Foley B, Doms RW, Blumenthal R
Retrovirology. 2006
PubMed ID: 17144914
The cell biology of HIV-1 and other retroviruses.
Freed EO, Mouland AJ
Retrovirology. 2006
PubMed ID: 17083721
Mechanism for complement-mediated, antibody-dependent enhancement of human immunodeficiency virus type 1 infection in MT2 cells is enhanced entry through CD4, CD21, and CXCR4 chemokine receptors.
Robinson WE
Viral Immunol. 2006
PubMed ID: 16987062
Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120.
Binley JM, Ngo-Abdalla S, Moore P, Bobardt M, Chatterji U, Gallay P, Burton DR, Wilson IA, Elder JH, de Parseval A
Retrovirology. 2006
PubMed ID: 16817962
Association between disruption of CD4 receptor dimerization and increased human immunodeficiency virus type 1 entry.
Bourgeois R, Mercier J, Paquette-Brooks I, Cohen EA
Retrovirology. 2006
PubMed ID: 16762062
Are blockers of gp120/CD4 interaction effective inhibitors of HIV-1 immunopathogenesis?
Herbeuval JP, Shearer GM
AIDS Rev. 2006
PubMed ID: 16736946
Inhibitors of HIV infection via the cellular CD4 receptor.
Vermeire K, Schols D, Bell TW
Curr Med Chem. 2006
PubMed ID: 16611063
Advances in HIV-1 entry inhibitors: strategies to interfere with receptor and coreceptor engagement.
Markovic I
Curr Pharm Des. 2006
PubMed ID: 16515489
Modelling thymic HIV-1 Nef effects.
Stove V, Verhasselt B
Curr HIV Res. 2006
PubMed ID: 16454711
CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium.
Bry L, Brigl M, Brenner MB
Infect Immun. 2006
PubMed ID: 16369024
SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling.
Evel-Kabler K, Song XT, Aldrich M, Huang XF, Chen SY
J Clin Invest. 2006
PubMed ID: 16357940
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Targeting LFA-1 and cd154 suppresses the in vivo activation and development of cytolytic (cd4-Independent) CD8+ T cells.
Lunsford KE, Koester MA, Eiring AM, Horne PH, Gao D, Bumgardner GL
J Immunol. 2005
PubMed ID: 16339521
Protein minimization of the gp120 binding region of human CD4.
Sharma D, Balamurali MM, Chakraborty K, Kumaran S, Jeganathan S, Rashid U, Ingallinella P, Varadarajan R
Biochemistry. 2005
PubMed ID: 16331979
The C-terminal region of cis-retinol/androgen dehydrogenase 1 (CRAD1) confers ER localization and in vivo enzymatic function.
Lidén M, Tryggvason K, Eriksson U
Exp Cell Res. 2005
PubMed ID: 16223484
Runx1 binds positive transcription elongation factor b and represses transcriptional elongation by RNA polymerase II: possible mechanism of CD4 silencing.
Jiang H, Zhang F, Kurosu T, Peterlin BM
Mol Cell Biol. 2005
PubMed ID: 16314494
A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development.
Bultman SJ, Gebuhr TC, Magnuson T
Genes Dev. 2005
PubMed ID: 16287714
Single-molecule analysis of human immunodeficiency virus type 1 gp120-receptor interactions in living cells.
Chang MI, Panorchan P, Dobrowsky TM, Tseng Y, Wirtz D
J Virol. 2005
PubMed ID: 16282475
Cross talk between growth factors and viral and cellular factors alters neuronal signaling pathways: implication for HIV-associated dementia.
Peruzzi F, Bergonzini V, Aprea S, Reiss K, Sawaya BE, Rappaport J, Amini S, Khalili K
Brain Res Brain Res Rev. 2005
PubMed ID: 15936090
CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis.
Herbeuval JP, Grivel JC, Boasso A, Hardy AW, Chougnet C, Dolan MJ, Yagita H, Lifson JD, Shearer GM
Blood. 2005
PubMed ID: 16046522
Structure of a V3-containing HIV-1 gp120 core.
Huang CC, Tang M, Zhang MY, Majeed S, Montabana E, Stanfield RL, Dimitrov DS, Korber B, Sodroski J, Wilson IA, Wyatt R, Kwong PD
Science. 2005
PubMed ID: 16284180
Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.
Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY
Cell Res. 2005
PubMed ID: 16354571
Decreased CD4 expression by polarized T helper 2 cells contributes to suboptimal TCR-induced phosphorylation and reduced Ca2+ signaling.
Itoh Y, Wang Z, Ishida H, Eichelberg K, Fujimoto N, Makino J, Ogasawara K, Germain RN
Eur J Immunol. 2005
PubMed ID: 16276482
CD4-dependent signaling is required for a late checkpoint during Th2 development associated with resistance to activation-induced cell death.
Tatari-Calderone Z, Brogdon JL, Tinsley KW, Ramezani A, Leitenberg D
J Immunol. 2005
PubMed ID: 16237052
Complex determinants in human immunodeficiency virus type 1 envelope gp120 mediate CXCR4-dependent infection of macrophages.
Ghaffari G, Tuttle DL, Briggs D, Burkhardt BR, Bhatt D, Andiman WA, Sleasman JW, Goodenow MM
J Virol. 2005
PubMed ID: 16227248
Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection.
Valenzuela-Fernández A, Alvarez S, Gordon-Alonso M, Barrero M, Ursa A, Cabrero JR, Fernández G, Naranjo-Suárez S, Yáñez-Mo M, Serrador JM, Muñoz-Fernández MA, Sánchez-Madrid F
Mol Biol Cell. 2005
PubMed ID: 16148047
Divergent functions of CD4+ T lymphocytes in acute liver inflammation and injury after ischemia-reperfusion.
Caldwell CC, Okaya T, Martignoni A, Husted T, Schuster R, Lentsch AB
Am J Physiol Gastrointest Liver Physiol. 2005
PubMed ID: 16002566
Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease.
Zorn E, Kim HT, Lee SJ, Floyd BH, Litsa D, Arumugarajah S, Bellucci R, Alyea EP, Antin JH, Soiffer RJ, Ritz J
Blood. 2005
PubMed ID: 15972448
Distinct functional sites for human immunodeficiency virus type 1 and stromal cell-derived factor 1alpha on CXCR4 transmembrane helical domains.
Tian S, Choi WT, Liu D, Pesavento J, Wang Y, An J, Sodroski JG, Huang Z
J Virol. 2005
PubMed ID: 16188969
Anti-HIV agents targeting the interaction of gp120 with the cellular CD4 receptor.
Vermeire K, Schols D
Expert Opin Investig Drugs. 2005
PubMed ID: 16185162
Fusion of HIV-1 envelope-expressing cells to human glomerular endothelial cells through an CXCR4-mediated mechanism.
Ray PE, Soler-García AA, Xu L, Soderland C, Blumenthal R, Puri A
Pediatr Nephrol. 2005
PubMed ID: 16047221
Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cells.
Herbeuval JP, Hardy AW, Boasso A, Anderson SA, Dolan MJ, Dy M, Shearer GM
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16174727
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent.
Jin YJ, Cai CY, Zhang X, Zhang HT, Hirst JA, Burakoff SJ
J Immunol. 2005
PubMed ID: 16116206
Involvement of fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila.
Kikuchi T, Andarini S, Xin H, Gomi K, Tokue Y, Saijo Y, Honjo T, Watanabe A, Nukiwa T
Infect Immun. 2005
PubMed ID: 16113250
Characterization of antibodies that inhibit HIV gp120 antigen processing and presentation.
Tuen M, Visciano ML, Chien PC, Cohen S, Chen PD, Robinson J, He Y, Pinter A, Gorny MK, Hioe CE
Eur J Immunol. 2005
PubMed ID: 16106369
Ternary complex formation of human immunodeficiency virus type 1 Env, CD4, and chemokine receptor captured as an intermediate of membrane fusion.
Mkrtchyan SR, Markosyan RM, Eadon MT, Moore JP, Melikyan GB, Cohen FS
J Virol. 2005
PubMed ID: 16103167
Identification of N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4.
Zhao Q, Ma L, Jiang S, Lu H, Liu S, He Y, Strick N, Neamati N, Debnath AK
Virology. 2005
PubMed ID: 15996703
Isolation of TAK-779-resistant HIV-1 from an R5 HIV-1 GP120 V3 loop library.
Yusa K, Maeda Y, Fujioka A, Monde K, Harada S
J Biol Chem. 2005
PubMed ID: 15983047
IL-10-dependent infectious tolerance after the treatment of experimental allergic encephalomyelitis with redirected CD4+CD25+ T lymphocytes.
Mekala DJ, Alli RS, Geiger TL
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16087867
Scrambling of the amino acids within the transmembrane domain of Vpu results in a simian-human immunodeficiency virus (SHIVTM) that is less pathogenic for pig-tailed macaques.
Hout DR, Gomez ML, Pacyniak E, Gomez LM, Inbody SH, Mulcahy ER, Culley N, Pinson DM, Powers MF, Wong SW, Stephens EB
Virology. 2005
PubMed ID: 15975620
Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells.
Grueter B, Petter M, Egawa T, Laule-Kilian K, Aldrian CJ, Wuerch A, Ludwig Y, Fukuyama H, Wardemann H, Waldschuetz R, Möröy T, Taniuchi I, Steimle V, Littman DR, Ehlers M
J Immunol. 2005
PubMed ID: 16034110
Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA).
Polianova MT, Ruscetti FW, Pert CB, Ruff MR
Antiviral Res. 2005
PubMed ID: 16002156
Purification and partial characterization of R5, R5X4, and X4 HIV-1 subtype C envelope glycoproteins expressed in insect cells.
Nkosi SP, Huismans H, Papathanasopoulos MA
J Med Virol. 2005
PubMed ID: 15977243
Mechanisms of apoptosis induction by the HIV-1 envelope.
Perfettini JL, Castedo M, Roumier T, Andreau K, Nardacci R, Piacentini M, Kroemer G
Cell Death Differ. 2005
PubMed ID: 15719026
Acquired T-cell sensitivity to TRAIL mediated killing during HIV infection is regulated by CXCR4-gp120 interactions.
Lum JJ, Schnepple DJ, Badley AD
AIDS. 2005
PubMed ID: 15990565
Restricted variable residues in the C-terminal segment of HIV-1 V3 loop regulate the molecular anatomy of CCR5 utilization.
Hu Q, Napier KB, Trent JO, Wang Z, Taylor S, Griffin GE, Peiper SC, Shattock RJ
J Mol Biol. 2005
PubMed ID: 15964018
Regulation of follicular dendritic cell networks by activated T cells: the role of CD137 signaling.
Sun Y, Blink SE, Chen JH, Fu YX
J Immunol. 2005
PubMed ID: 16002686
Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.
Sarafova SD, Erman B, Yu Q, Van Laethem F, Guinter T, Sharrow SO, Feigenbaum L, Wildt KF, Ellmeier W, Singer A
Immunity. 2005
PubMed ID: 16039581
Detection of human immunodeficiency virus type 1 Nef and CD4 physical interaction in living human cells by using bioluminescence resonance energy transfer.
Cluet D, Bertsch C, Beyer C, Gloeckler L, Erhardt M, Gut JP, Galzi JL, Aubertin AM
J Virol. 2005
PubMed ID: 15956605
Virus isolates during acute and chronic human immunodeficiency virus type 1 infection show distinct patterns of sensitivity to entry inhibitors.
Rusert P, Kuster H, Joos B, Misselwitz B, Gujer C, Leemann C, Fischer M, Stiegler G, Katinger H, Olson WC, Weber R, Aceto L, Günthard HF, Trkola A
J Virol. 2005
PubMed ID: 15956589
Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation.
Elzey BD, Grant JF, Sinn HW, Nieswandt B, Waldschmidt TJ, Ratliff TL
J Leukoc Biol. 2005
PubMed ID: 15899982
Airway hyperresponsiveness in the absence of CD4+ T cells after primary but not secondary challenge.
Joetham A, Takeda K, Taube C, Miyahara N, Kanehiro A, Dakhama A, Gelfand EW
Am J Respir Cell Mol Biol. 2005
PubMed ID: 15845865
Accelerated chemically induced tumor development mediated by CD4+CD25+ regulatory T cells in wild-type hosts.
Nishikawa H, Kato T, Tawara I, Takemitsu T, Saito K, Wang L, Ikarashi Y, Wakasugi H, Nakayama T, Taniguchi M, Kuribayashi K, Old LJ, Shiku H
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15961541
B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88.
Yang R, Murillo FM, Delannoy MJ, Blosser RL, Yutzy WH, Uematsu S, Takeda K, Akira S, Viscidi RP, Roden RB
J Immunol. 2005
PubMed ID: 15944297
The role of host CD4 T cells in the pathogenesis of the chronic graft-versus-host model of systemic lupus erythematosus.
Choudhury A, Maldonado MA, Cohen PL, Eisenberg RA
J Immunol. 2005
PubMed ID: 15944260
A new dynamic model of CD8+ T effector cell responses via CD4+ T helper-antigen-presenting cells.
Xiang J, Huang H, Liu Y
J Immunol. 2005
PubMed ID: 15944248
Ontogeny of CD4+CD25+ regulatory/suppressor T cells in human fetuses.
Darrasse-Jèze G, Marodon G, Salomon BL, Catala M, Klatzmann D
Blood. 2005
PubMed ID: 15731180
Heparan sulfate targets the HIV-1 envelope glycoprotein gp120 coreceptor binding site.
Vivès RR, Imberty A, Sattentau QJ, Lortat-Jacob H
J Biol Chem. 2005
PubMed ID: 15797855
CD4+ T cells play a dominant role in protection against New World leishmaniasis induced by vaccination with the P-4 amastigote antigen.
Kar S, Metz C, McMahon-Pratt D
Infect Immun. 2005
PubMed ID: 15908422
Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene.
Zhang DJ, Wang Q, Wei J, Baimukanova G, Buchholz F, Stewart AF, Mao X, Killeen N
J Immunol. 2005
PubMed ID: 15905512
Cryptic nature of a conserved, CD4-inducible V3 loop neutralization epitope in the native envelope glycoprotein oligomer of CCR5-restricted, but not CXCR4-using, primary human immunodeficiency virus type 1 strains.
Lusso P, Earl PL, Sironi F, Santoro F, Ripamonti C, Scarlatti G, Longhi R, Berger EA, Burastero SE
J Virol. 2005
PubMed ID: 15890935
Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer.
Yang R, Wheeler CM, Chen X, Uematsu S, Takeda K, Akira S, Pastrana DV, Viscidi RP, Roden RB
J Virol. 2005
PubMed ID: 15890912
Interaction with CD4 and antibodies to CD4-induced epitopes of the envelope gp120 from a microglial cell-adapted human immunodeficiency virus type 1 isolate.
Martín-García J, Cocklin S, Chaiken IM, González-Scarano F
J Virol. 2005
PubMed ID: 15890908
Complementary role of CD4+CD25+ regulatory T cells and TGF-beta in oral tolerance.
Chung Y, Lee SH, Kim DH, Kang CY
J Leukoc Biol. 2005
PubMed ID: 15758078
Proteins that bind high-mannose sugars of the HIV envelope.
Botos I, Wlodawer A
Prog Biophys Mol Biol. 2005
PubMed ID: 15572157
Augmented Induction of CD4+CD25+ Treg using monoclonal antibodies to CD200R.
Gorczynski RM, Lee L, Boudakov I
Transplantation. 2005
PubMed ID: 15880066
Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms.
Min B, Yamane H, Hu-Li J, Paul WE
J Immunol. 2005
PubMed ID: 15879097
Identification of a region within the cytoplasmic domain of the subtype B Vpu protein of human immunodeficiency virus type 1 (HIV-1) that is responsible for retention in the golgi complex and its absence in the Vpu protein from a subtype C HIV-1.
Pacyniak E, Gomez ML, Gomez LM, Mulcahy ER, Jackson M, Hout DR, Wisdom BJ, Stephens EB
AIDS Res Hum Retroviruses. 2005
PubMed ID: 15929700
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent.
de Visser KE, Korets LV, Coussens LM
Cancer Cell. 2005
PubMed ID: 15894262
Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth.
Huang CC, Stricher F, Martin L, Decker JM, Majeed S, Barthe P, Hendrickson WA, Robinson J, Roumestand C, Sodroski J, Wyatt R, Shaw GM, Vita C, Kwong PD
Structure. 2005
PubMed ID: 15893666
Discovery of small-molecule human immunodeficiency virus type 1 entry inhibitors that target the gp120-binding domain of CD4.
Yang QE, Stephen AG, Adelsberger JW, Roberts PE, Zhu W, Currens MJ, Feng Y, Crise BJ, Gorelick RJ, Rein AR, Fisher RJ, Shoemaker RH, Sei S
J Virol. 2005
PubMed ID: 15857997
Functional mimicry of a human immunodeficiency virus type 1 coreceptor by a neutralizing monoclonal antibody.
Xiang SH, Farzan M, Si Z, Madani N, Wang L, Rosenberg E, Robinson J, Sodroski J
J Virol. 2005
PubMed ID: 15857992
CD4+ T cells but Not CD8+ or gammadelta+ lymphocytes are required for host protection against Mycobacterium avium infection and dissemination through the intestinal route.
Petrofsky M, Bermudez LE
Infect Immun. 2005
PubMed ID: 15845464
Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells.
Xin H, Kikuchi T, Andarini S, Ohkouchi S, Suzuki T, Nukiwa T, Huqun, Hagiwara K, Honjo T, Saijo Y
Eur J Immunol. 2005
PubMed ID: 15789339
The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4.
Michel N, Allespach I, Venzke S, Fackler OT, Keppler OT
Curr Biol. 2005
PubMed ID: 15854903
Vpu-mediated CD4 down-regulation and degradation is conserved among highly divergent SIV(cpz) strains.
Gomez LM, Pacyniak E, Flick M, Hout DR, Gomez ML, Nerrienet E, Ayouba A, Santiago ML, Hahn BH, Stephens EB
Virology. 2005
PubMed ID: 15823605
Physiological relevance of antigen presentasome (APS), an acquired MHC/costimulatory complex, in the sustained activation of CD4+ T cells in the absence of APCs.
Zhou J, Tagaya Y, Tolouei-Semnani R, Schlom J, Sabzevari H
Blood. 2005
PubMed ID: 15637136
Influence of membrane fluidity on human immunodeficiency virus type 1 entry.
Harada S, Yusa K, Monde K, Akaike T, Maeda Y
Biochem Biophys Res Commun. 2005
PubMed ID: 15737612
Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization.
Winkler IG, Hendy J, Coughlin P, Horvath A, Lévesque JP
J Exp Med. 2005
PubMed ID: 15795238
Differential effects of R5 and X4 human immunodeficiency virus type 1 infection on CD4+ cell proliferation and activation.
Locher CP, Witt SA, Kassel R, Dowell NL, Fujimura S, Levy JA
J Gen Virol. 2005
PubMed ID: 15784911
Galectin-1 acts as a soluble host factor that promotes HIV-1 infectivity through stabilization of virus attachment to host cells.
Ouellet M, Mercier S, Pelletier I, Bounou S, Roy J, Hirabayashi J, Sato S, Tremblay MJ
J Immunol. 2005
PubMed ID: 15778371
Variants of human immunodeficiency virus type 1 that efficiently use CCR5 lacking the tyrosine-sulfated amino terminus have adaptive mutations in gp120, including loss of a functional N-glycan.
Platt EJ, Shea DM, Rose PP, Kabat D
J Virol. 2005
PubMed ID: 15767436
Kinetic factors control efficiencies of cell entry, efficacies of entry inhibitors, and mechanisms of adaptation of human immunodeficiency virus.
Platt EJ, Durnin JP, Kabat D
J Virol. 2005
PubMed ID: 15767435
Dynamic reorganization of chemokine receptors, cholesterol, lipid rafts, and adhesion molecules to sites of CD4 engagement.
Nguyen DH, Giri B, Collins G, Taub DD
Exp Cell Res. 2005
PubMed ID: 15748900
Marked structural and functional heterogeneity in CXCR4: separation of HIV-1 and SDF-1alpha responses.
Sloane AJ, Raso V, Dimitrov DS, Xiao X, Deo S, Muljadi N, Restuccia D, Turville S, Kearney C, Broder CC, Zoellner H, Cunningham AL, Bendall L, Lynch GW
Immunol Cell Biol. 2005
PubMed ID: 15748209
Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer.
Schaefer C, Kim GG, Albers A, Hoermann K, Myers EN, Whiteside TL
Br J Cancer. 2005
PubMed ID: 15714205
Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp.
Mori T, O'Keefe BR, Sowder RC, Bringans S, Gardella R, Berg S, Cochran P, Turpin JA, Buckheit RW, McMahon JB, Boyd MR
J Biol Chem. 2005
PubMed ID: 15613479
Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period.
Bayer AL, Yu A, Adeegbe D, Malek TR
J Exp Med. 2005
PubMed ID: 15753210
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells.
Fahlén L, Read S, Gorelik L, Hurst SD, Coffman RL, Flavell RA, Powrie F
J Exp Med. 2005
PubMed ID: 15753207
Definition of target antigens for naturally occurring CD4(+) CD25(+) regulatory T cells.
Nishikawa H, Kato T, Tawara I, Saito K, Ikeda H, Kuribayashi K, Allen PM, Schreiber RD, Sakaguchi S, Old LJ, Shiku H
J Exp Med. 2005
PubMed ID: 15753203
Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis.
Zhou X, Robertson AK, Rudling M, Parini P, Hansson GK
Circ Res. 2005
PubMed ID: 15662027
CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms.
Rose JJ, Janvier K, Chandrasekhar S, Sekaly RP, Bonifacino JS, Venkatesan S
J Biol Chem. 2005
PubMed ID: 15611114
Lower CD4+ T lymphocyte nadirs may indicate limited immune reconstitution in HIV-1 infected individuals on potent antiretroviral therapy: analysis of immunophenotypic marker results of AACTG 5067.
D'Amico R, Yang Y, Mildvan D, Evans SR, Schnizlein-Bick CT, Hafner R, Webb N, Basar M, Zackin R, Jacobson MA
J Clin Immunol. 2005
PubMed ID: 15821887
Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes.
Sato T, Ohno S, Hayashi T, Sato C, Kohu K, Satake M, Habu S
Immunity. 2005
PubMed ID: 15780989
CD4+CD25+ regulatory T cells control innate immune reactivity after injury.
Murphy TJ, Ni Choileain N, Zang Y, Mannick JA, Lederer JA
J Immunol. 2005
PubMed ID: 15728508
Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage.
Kohu K, Sato T, Ohno S, Hayashi K, Uchino R, Abe N, Nakazato M, Yoshida N, Kikuchi T, Iwakura Y, Inoue Y, Watanabe T, Habu S, Satake M
J Immunol. 2005
PubMed ID: 15728469
CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.
Antony PA, Piccirillo CA, Akpinarli A, Finkelstein SE, Speiss PJ, Surman DR, Palmer DC, Chan CC, Klebanoff CA, Overwijk WW, Rosenberg SA, Restifo NP
J Immunol. 2005
PubMed ID: 15728465
Nef expressed from human immunodeficiency virus type 1 extrachromosomal DNA downregulates CD4 on primary CD4+ T lymphocytes: implications for integrase inhibitors.
Gillim-Ross L, Cara A, Klotman ME
J Gen Virol. 2005
PubMed ID: 15722538
Notch1 co-localizes with CD4 on activated T cells and Notch signaling is required for IL-10 production.
Benson RA, Adamson K, Corsin-Jimenez M, Marley JV, Wahl KA, Lamb JR, Howie SE
Eur J Immunol. 2005
PubMed ID: 15688350
Immune mediators in a murine model for occupational asthma: studies with toluene diisocyanate.
Matheson JM, Johnson VJ, Luster MI
Toxicol Sci. 2005
PubMed ID: 15590890
Structure of an unliganded simian immunodeficiency virus gp120 core.
Chen B, Vogan EM, Gong H, Skehel JJ, Wiley DC, Harrison SC
Nature. 2005
PubMed ID: 15729334
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.
Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, von Boehmer H, Aifantis I
J Exp Med. 2005
PubMed ID: 15728238
Cutting edge: antibody production to pneumococcal polysaccharides requires CD1 molecules and CD8+ T cells.
Kobrynski LJ, Sousa AO, Nahmias AJ, Lee FK
J Immunol. 2005
PubMed ID: 15699104
Down-regulation of myasthenogenic T cell responses by a dual altered peptide ligand via CD4+CD25+-regulated events leading to apoptosis.
Ben-David H, Sela M, Mozes E
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15677327
Linkage to peroxisome proliferator-activated receptor-gamma in SAMP1/YitFc mice and in human Crohn's disease.
Sugawara K, Olson TS, Moskaluk CA, Stevens BK, Hoang S, Kozaiwa K, Cominelli F, Ley KF, McDuffie M
Gastroenterology. 2005
PubMed ID: 15685547
Characterization of gp120 and its single-chain derivatives, gp120-CD4D12 and gp120-M9: implications for targeting the CD4i epitope in human immunodeficiency virus vaccine design.
Varadarajan R, Sharma D, Chakraborty K, Patel M, Citron M, Sinha P, Yadav R, Rashid U, Kennedy S, Eckert D, Geleziunas R, Bramhill D, Schleif W, Liang X, Shiver J
J Virol. 2005
PubMed ID: 15650196
Tolerizing effects of co-stimulation blockade rest on functional dominance of CD4+CD25+ regulatory T cells.
Coenen JJ, Koenen HJ, van Rijssen E, Hilbrands LB, Joosten I
Transplantation. 2005
PubMed ID: 15665762
Cutting edge: MHC class II-restricted killing in vivo during viral infection.
Jellison ER, Kim SK, Welsh RM
J Immunol. 2005
PubMed ID: 15634878
An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4.
Kao H, Allen PM
J Exp Med. 2005
PubMed ID: 15630142
Blockade of chemokine-induced signalling inhibits CCR5-dependent HIV infection in vitro without blocking gp120/CCR5 interaction.
Grainger DJ, Lever AM
Retrovirology. 2005
PubMed ID: 15807900
Immunogenicity of HIV type 1 gp120 CD4 binding site phage mimotopes.
Dorgham K, Dogan I, Bitton N, Parizot C, Cardona V, Debré P, Hartley O, Gorochov G
AIDS Res Hum Retroviruses. 2005
PubMed ID: 15665647
Nef: "necessary and enforcing factor" in HIV infection.
Joseph AM, Kumar M, Mitra D
Curr HIV Res. 2005
PubMed ID: 15638726
Peptide-specific intercellular transfer of MHC class II to CD4+ T cells directly from the immunological synapse upon cellular dissociation.
Wetzel SA, McKeithan TW, Parker DC
J Immunol. 2005
PubMed ID: 15611230
Entropy calculation of HIV-1 Env gp120, its receptor CD4, and their complex: an analysis of configurational entropy changes upon complexation.
Hsu ST, Peter C, van Gunsteren WF, Bonvin AM
Biophys J. 2005
PubMed ID: 15489307
CXCR4-tropic HIV-1 envelope glycoprotein functions as a viral chemokine in unstimulated primary CD4+ T lymphocytes.
Balabanian K, Harriague J, Décrion C, Lagane B, Shorte S, Baleux F, Virelizier JL, Arenzana-Seisdedos F, Chakrabarti LA
J Immunol. 2004
PubMed ID: 15585836
High level of coreceptor-independent HIV transfer induced by contacts between primary CD4 T cells.
Blanco J, Bosch B, Fernández-Figueras MT, Barretina J, Clotet B, Esté JA
J Biol Chem. 2004
PubMed ID: 15371410
Peyer's patch dendritic cells capturing oral antigen interact with antigen-specific T cells and induce gut-homing CD4(+)CD25(+) regulatory T cells in Peyer's patches.
Nagatani K, Sagawa K, Komagata Y, Yamamoto K
Ann N Y Acad Sci. 2004
PubMed ID: 15681783
Prolactin gene expression in mouse spleen helper T cells.
Horiguchi K, Yagi S, Ono K, Nishiura Y, Tanaka M, Ishida M, Harigaya T
J Endocrinol. 2004
PubMed ID: 15590989
Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice.
Elhage R, Gourdy P, Brouchet L, Jawien J, Fouque MJ, Fiévet C, Huc X, Barreira Y, Couloumiers JC, Arnal JF, Bayard F
Am J Pathol. 2004
PubMed ID: 15579444
Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies.
Binley JM, Wrin T, Korber B, Zwick MB, Wang M, Chappey C, Stiegler G, Kunert R, Zolla-Pazner S, Katinger H, Petropoulos CJ, Burton DR
J Virol. 2004
PubMed ID: 15542675
CADA, a novel CD4-targeted HIV inhibitor, is synergistic with various anti-HIV drugs in vitro.
Vermeire K, Princen K, Hatse S, De Clercq E, Dey K, Bell TW, Schols D
AIDS. 2004
PubMed ID: 15577644
Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient mice.
Bommireddy R, Engle SJ, Ormsby I, Boivin GP, Babcock GF, Doetschman T
Cell Immunol. 2004
PubMed ID: 15922720
Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4.
Wang J, Alvarez R, Roderiquez G, Guan E, Norcross MA
J Cell Biochem. 2004
PubMed ID: 15660419
CD4 phosphorylation partially reverses Nef down-regulation of CD4.
Jin YJ, Zhang X, Boursiquot JG, Burakoff SJ
J Immunol. 2004
PubMed ID: 15494497
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
Palacios EH, Weiss A
Oncogene. 2004
PubMed ID: 15489916
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor.
Chiang EY, Stroynowski I
J Immunol. 2004
PubMed ID: 15383569
BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses.
Ye Q, Wang L, Wells AD, Tao R, Han R, Davidson A, Scott ML, Hancock WW
Eur J Immunol. 2004
PubMed ID: 15368291
Signal peptide prediction based on analysis of experimentally verified cleavage sites.
Zhang Z, Henzel WJ
Protein Sci. 2004
PubMed ID: 15340161
Domain swapping of CD4 upon dimerization.
Sanejouand YH
Proteins. 2004
PubMed ID: 15326605
R5 HIV gp120-mediated cellular contacts induce the death of single CCR5-expressing CD4 T cells by a gp41-dependent mechanism.
Blanco J, Barretina J, Clotet B, Esté JA
J Leukoc Biol. 2004
PubMed ID: 15258189
Presence of IFN-gamma does not indicate its necessity for induction of coronary arteritis in an animal model of Kawasaki disease.
Chan WC, Duong TT, Yeung RS
J Immunol. 2004
PubMed ID: 15322214
A novel mutation in CD83 results in the development of a unique population of CD4+ T cells.
García-Martínez LF, Appleby MW, Staehling-Hampton K, Andrews DM, Chen Y, McEuen M, Tang P, Rhinehart RL, Proll S, Paeper B, Brunkow ME, Grandea AG, Howard ED, Walker DE, Charmley P, Jonas M, Shaw S, Latham JA, Ramsdell F
J Immunol. 2004
PubMed ID: 15322158
A novel assay to identify entry inhibitors that block binding of HIV-1 gp120 to CCR5.
Zhao Q, He Y, Alespeiti G, Debnath AK
Virology. 2004
PubMed ID: 15321703
Mobility of the human immunodeficiency virus (HIV) receptor CD4 and coreceptor CCR5 in living cells: implications for HIV fusion and entry events.
Steffens CM, Hope TJ
J Virol. 2004
PubMed ID: 15308751
Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody.
Zhang MY, Xiao X, Sidorov IA, Choudhry V, Cham F, Zhang PF, Bouma P, Zwick M, Choudhary A, Montefiori DC, Broder CC, Burton DR, Quinnan GV, Dimitrov DS
J Virol. 2004
PubMed ID: 15308718
CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice.
Lin X, Ma X, Rodriguez M, Roos RP
Int Immunol. 2004
PubMed ID: 15262897
Functional characterization of MHC class II-restricted CD8+CD4- and CD8-CD4- T cell responses to infection in CD4-/- mice.
Pearce EL, Shedlock DJ, Shen H
J Immunol. 2004
PubMed ID: 15294964
Regulated expression of the receptor-like tyrosine phosphatase CD148 on hemopoietic cells.
Lin J, Zhu JW, Baker JE, Weiss A
J Immunol. 2004
PubMed ID: 15294945
Monoallelic expression of mouse Cd4 gene.
Capparelli R, Costabile A, Viscardi M, Iannelli D
Mamm Genome. 2004
PubMed ID: 15457337
HIV-1 gp120 binding to dendritic cell receptors mobilize the virus to the lymph nodes, but the induced IL-4 synthesis by FcepsilonRI+ hematopoietic cells damages the adaptive immunity--a review, hypothesis, and implications.
Becker Y
Virus Genes. 2004
PubMed ID: 15215692
CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development.
McKee AS, Pearce EJ
J Immunol. 2004
PubMed ID: 15240714
Molecular genetic analysis of TPO and CD4 loci among two endogamous ethnic groups of Maharashtra in Western India.
Das B, Seshadri M
J Forensic Sci. 2004
PubMed ID: 15317218
Vpu: a multifunctional protein that enhances the pathogenesis of human immunodeficiency virus type 1.
Hout DR, Mulcahy ER, Pacyniak E, Gomez LM, Gomez ML, Stephens EB
Curr HIV Res. 2004
PubMed ID: 15279589
Glycosylation of the ENV spike of primate immunodeficiency viruses and antibody neutralization.
Pikora CA
Curr HIV Res. 2004
PubMed ID: 15279588
Different costimulatory and growth factor requirements for CD4+ and CD8+ T cell-mediated rejection.
Vu MD, Amanullah F, Li Y, Demirci G, Sayegh MH, Li XC
J Immunol. 2004
PubMed ID: 15210777
Differences in signaling molecule organization between naive and memory CD4+ T lymphocytes.
Watson AR, Lee WT
J Immunol. 2004
PubMed ID: 15210756
Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced
Peters PJ, Bhattacharya J, Hibbitts S, Dittmar MT, Simmons G, Bell J, Simmonds P, Clapham PR
J Virol. 2004
PubMed ID: 15194768
Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors.
Kirchhoff F, Schindler M, Bailer N, Renkema GH, Saksela K, Knoop V, Müller-Trutwin MC, Santiago ML, Bibollet-Ruche F, Dittmar MT, Heeney JL, Hahn BH, Münch J
J Virol. 2004
PubMed ID: 15194762
Regulation of CXCR4 receptor dimerization by the chemokine SDF-1alpha and the HIV-1 coat protein gp120: a fluorescence resonance energy transfer (FRET) study.
Toth PT, Ren D, Miller RJ
J Pharmacol Exp Ther. 2004
PubMed ID: 15014135
ARF1 regulates Nef-induced CD4 degradation.
Fauré J, Stalder R, Borel C, Sobo K, Piguet V, Demaurex N, Gruenberg J, Trono D
Curr Biol. 2004
PubMed ID: 15202998
HIV-1 acute infection env glycomutants designed from 3D model: effects on processing, antigenicity, and neutralization sensitivity.
Reynard F, Fatmi A, Verrier B, Bedin F
Virology. 2004
PubMed ID: 15183057
The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development.
Williams CJ, Naito T, Arco PG, Seavitt JR, Cashman SM, De Souza B, Qi X, Keables P, Von Andrian UH, Georgopoulos K
Immunity. 2004
PubMed ID: 15189737
Multiple human immunodeficiency virus type 1 Nef functions contribute to efficient replication in primary human macrophages.
Brown A, Moghaddam S, Kawano T, Cheng-Mayer C
J Gen Virol. 2004
PubMed ID: 15166429
Nef from a primary isolate of human immunodeficiency virus type 1 lacking the EE(155) region shows decreased ability to down-regulate CD4.
Na YS, Yoon K, Nam JG, Choi B, Lee JS, Kato I, Kim S
J Gen Virol. 2004
PubMed ID: 15166428
Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection.
Bitsaktsis C, Huntington J, Winslow G
J Immunol. 2004
PubMed ID: 15153508
Design, synthesis and evaluation of potential inhibitors of HIV gp120-CD4 interactions.
Boussard C, Klimkait T, Mahmood N, Pritchard M, Gilbert IH
Bioorg Med Chem Lett. 2004
PubMed ID: 15109676
Toll-like receptor ligands directly promote activated CD4+ T cell survival.
Gelman AE, Zhang J, Choi Y, Turka LA
J Immunol. 2004
PubMed ID: 15128790
CD4 raft association and signaling regulate molecular clustering at the immunological synapse site.
Balamuth F, Brogdon JL, Bottomly K
J Immunol. 2004
PubMed ID: 15128768
Impact of mutations in the coreceptor binding site on human immunodeficiency virus type 1 fusion, infection, and entry inhibitor sensitivity.
Reeves JD, Miamidian JL, Biscone MJ, Lee FH, Ahmad N, Pierson TC, Doms RW
J Virol. 2004
PubMed ID: 15113926
CD4-induced T-20 binding to human immunodeficiency virus type 1 gp120 blocks interaction with the CXCR4 coreceptor.
Yuan W, Craig S, Si Z, Farzan M, Sodroski J
J Virol. 2004
PubMed ID: 15113923
CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease.
Weng X, Priceputu E, Chrobak P, Poudrier J, Kay DG, Hanna Z, Mak TW, Jolicoeur P
J Virol. 2004
PubMed ID: 15113906
Migration of antigen-specific T cells away from CXCR4-binding human immunodeficiency virus type 1 gp120.
Brainard DM, Tharp WG, Granado E, Miller N, Trocha AK, Ren XH, Conrad B, Terwilliger EF, Wyatt R, Walker BD, Poznansky MC
J Virol. 2004
PubMed ID: 15113900
Essential role of MHC II-independent CD4+ T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse.
Takeshita K, Yamasaki T, Akira S, Gantner F, Bacon KB
Int Immunol. 2004
PubMed ID: 15096484
CD95/phosphorylated ezrin association underlies HIV-1 GP120/IL-2-induced susceptibility to CD95(APO-1/Fas)-mediated apoptosis of human resting CD4(+)T lymphocytes.
Luciani F, Matarrese P, Giammarioli AM, Lugini L, Lozupone F, Federici C, Iessi E, Malorni W, Fais S
Cell Death Differ. 2004
PubMed ID: 14739941
Genetic variations in humans associated with differences in the course of hepatitis C.
Saito T, Ji G, Shinzawa H, Okumoto K, Hattori E, Adachi T, Takeda T, Sugahara K, Ito JI, Watanabe H, Saito K, Togashi H, Ishii K, Matsuura T, Inageda K, Muramatsu M, Kawata S
Biochem Biophys Res Commun. 2004
PubMed ID: 15063762
Vpu-mediated degradation of CD4 reconstituted in yeast reveals mechanistic differences to cellular ER-associated protein degradation.
Meusser B, Sommer T
Mol Cell. 2004
PubMed ID: 15099523
Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins.
Si Z, Madani N, Cox JM, Chruma JJ, Klein JC, Schön A, Phan N, Wang L, Biorn AC, Cocklin S, Chaiken I, Freire E, Smith AB, Sodroski JG
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15051887
HIV accessory proteins and surviving the host cell.
Anderson JL, Hope TJ
Curr HIV/AIDS Rep. 2004
PubMed ID: 16091223
HIV/SIV escape from immune surveillance: focus on Nef.
Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M
Curr HIV Res. 2004
PubMed ID: 15078178
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
Genome Res. 2004
PubMed ID: 15060019
Analysis of proteins copurifying with the CD4/lck complex using one-dimensional polyacrylamide gel electrophoresis and mass spectrometry: comparison with affinity-tag based protein detection and evaluation of different solubilization methods.
Bernhard OK, Cunningham AL, Sheil MM
J Am Soc Mass Spectrom. 2004
PubMed ID: 15047060
Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections.
Fuller MJ, Khanolkar A, Tebo AE, Zajac AJ
J Immunol. 2004
PubMed ID: 15034033
Localized changes in the gp120 envelope glycoprotein confer resistance to human immunodeficiency virus entry inhibitors BMS-806 and #155.
Madani N, Perdigoto AL, Srinivasan K, Cox JM, Chruma JJ, LaLonde J, Head M, Smith AB, Sodroski JG
J Virol. 2004
PubMed ID: 15016894
N-linked glycosylation of the V3 loop and the immunologically silent face of gp120 protects human immunodeficiency virus type 1 SF162 from neutralization by anti-gp120 and anti-gp41 antibodies.
McCaffrey RA, Saunders C, Hensel M, Stamatatos L
J Virol. 2004
PubMed ID: 15016849
Assembly, structure, and antigenic properties of virus-like particles rich in HIV-1 envelope gp120.
Berkower I, Raymond M, Muller J, Spadaccini A, Aberdeen A
Virology. 2004
PubMed ID: 15033567
Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells.
Sun JC, Bevan MJ
J Immunol. 2004
PubMed ID: 15004136
Identification of a novel CD4i human monoclonal antibody Fab that neutralizes HIV-1 primary isolates from different clades.
Zhang MY, Shu Y, Sidorov I, Dimitrov DS
Antiviral Res. 2004
PubMed ID: 15168796
Phenotypic and genotypic comparisons of CCR5- and CXCR4-tropic human immunodeficiency virus type 1 biological clones isolated from subtype C-infected individuals.
Pollakis G, Abebe A, Kliphuis A, Chalaby MI, Bakker M, Mengistu Y, Brouwer M, Goudsmit J, Schuitemaker H, Paxton WA
J Virol. 2004
PubMed ID: 14990703
CD4 T cell-dependent CD8 T cell maturation.
Khanolkar A, Fuller MJ, Zajac AJ
J Immunol. 2004
PubMed ID: 14978084
Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T cell subsets may contribute differently to the pathogenesis.
Chen Z, Yu S, Concha HQ, Zhu Y, Mix E, Winblad B, Ljunggren HG, Zhu J
Brain Behav Immun. 2004
PubMed ID: 14759595
Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry.
Markovic I, Stantchev TS, Fields KH, Tiffany LJ, Tomiç M, Weiss CD, Broder CC, Strebel K, Clouse KA
Blood. 2004
PubMed ID: 14592831
Expression and characterisation of recombinant oligomeric envelope glycoproteins derived from primary isolates of HIV-1.
Jeffs SA, Goriup S, Kebble B, Crane D, Bolgiano B, Sattentau Q, Jones S, Holmes H
Vaccine. 2004
PubMed ID: 15161081
Mode of action for linear peptide inhibitors of HIV-1 gp120 interactions.
Biorn AC, Cocklin S, Madani N, Si Z, Ivanovic T, Samanen J, Van Ryk DI, Pantophlet R, Burton DR, Freire E, Sodroski J, Chaiken IM
Biochemistry. 2004
PubMed ID: 14967033
The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells.
Tyznik AJ, Sun JC, Bevan MJ
J Exp Med. 2004
PubMed ID: 14769854
Key roles of CD4+ T cells and IFN-gamma in the development of abdominal aortic aneurysms in a murine model.
Xiong W, Zhao Y, Prall A, Greiner TC, Baxter BT
J Immunol. 2004
PubMed ID: 14764734
CXCR4 engagement is required for HIV-1-induced L-selectin shedding.
Wang J, Marschner S, Finkel TH
Blood. 2004
PubMed ID: 14576059
Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.
Gorska MM, Stafford SJ, Cen O, Sur S, Alam R
J Exp Med. 2004
PubMed ID: 14757743
The N-terminal of the V3 loop in HIV type 1 gp120 is responsible for its conformation-dependent interaction with cell surface molecules.
Ling H, Usami O, Xiao P, Gu HX, Hattori T
AIDS Res Hum Retroviruses. 2004
PubMed ID: 15018709
Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.
Leavitt SA, SchOn A, Klein JC, Manjappara U, Chaiken IM, Freire E
Curr Protein Pept Sci. 2004
PubMed ID: 14965316
Human immunodeficiency virus type 1 Nef associates with lipid rafts to downmodulate cell surface CD4 and class I major histocompatibility complex expression and to increase viral infectivity.
Alexander M, Bor YC, Ravichandran KS, Hammarskjöld ML, Rekosh D
J Virol. 2004
PubMed ID: 14747534
Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases.
Fujimoto M, Tsutsui H, Xinshou O, Tokumoto M, Watanabe D, Shima Y, Yoshimoto T, Hirakata H, Kawase I, Nakanishi K, Kishimoto T, Naka T
Int Immunol. 2004
PubMed ID: 14734616
Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins.
Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Früh K
J Virol. 2004
PubMed ID: 14722266
Lateral membrane protein associations of CD4 in lymphoid cells detected by cross-linking and mass spectrometry.
Bernhard OK, Sheil MM, Cunningham AL
Biochemistry. 2004
PubMed ID: 14705953
Detection of IgA inhibiting the interaction between gp120 and soluble CD4 receptor in serum and saliva of HIV-1-infected patients.
Vincent N, Malvoisin E, Pozzetto B, Lucht F, Genin C
AIDS. 2004
PubMed ID: 15090827
The functional consequences of delivery of HIV-1 Nef to dendritic cells using an adenoviral vector.
Maccormac LP, Jacque JM, Chain B
Vaccine. 2004
PubMed ID: 14670336
CD4 receptor localized to non-raft membrane microdomains supports HIV-1 entry. Identification of a novel raft localization marker in CD4.
Popik W, Alce TM
J Biol Chem. 2004
PubMed ID: 14570906
HIV-1 Vpu sequesters beta-transducin repeat-containing protein (betaTrCP) in the cytoplasm and provokes the accumulation of beta-catenin and other SCFbetaTrCP substrates.
Besnard-Guerin C, Belaïdouni N, Lassot I, Segeral E, Jobart A, Marchal C, Benarous R
J Biol Chem. 2004
PubMed ID: 14561767
CD4 down-modulating compounds with potent anti-HIV activity.
Vermeire K, Schols D, Bell TW
Curr Pharm Des. 2004
PubMed ID: 15180541
A novel class of HIV-1 inhibitors that targets the viral envelope and inhibits CD4 receptor binding.
Wang HG, Williams RE, Lin PF
Curr Pharm Des. 2004
PubMed ID: 15180540
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells.
Eberl G, Marmon S, Sunshine MJ, Rennert PD, Choi Y, Littman DR
Nat Immunol. 2004
PubMed ID: 14691482
Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen.
Bry L, Brenner MB
J Immunol. 2004
PubMed ID: 14688352
Delayed clearance of Ehrlichia chaffeensis infection in CD4+ T-cell knockout mice.
Ganta RR, Cheng C, Wilkerson MJ, Chapes SK
Infect Immun. 2004
PubMed ID: 14688093
Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4).
Suzuki M, Hirao A, Mizuno A
J Biol Chem. 2003
PubMed ID: 14517216
Role of the fusion peptide and membrane-proximal domain in HIV-1 envelope glycoprotein-mediated membrane fusion.
Dimitrov AS, Rawat SS, Jiang S, Blumenthal R
Biochemistry. 2003
PubMed ID: 14640682
Mitochondrial apoptosis induced by the HIV-1 envelope.
Castedo M, Perfettini JL, Andreau K, Roumier T, Piacentini M, Kroemer G
Ann N Y Acad Sci. 2003
PubMed ID: 15033690
The expansion of CD4+CD28- T cells in patients with chronic kidney graft rejection.
Pawlik A, Florczak M, Masiuk M, Dutkiewicz G, Machalinski B, Rozanski J, Domanski L, Gawrońska-Szklarz B
Transplant Proc. 2003
PubMed ID: 14697933
Broadly cross-reactive HIV neutralizing human monoclonal antibody Fab selected by sequential antigen panning of a phage display library.
Zhang MY, Shu Y, Phogat S, Xiao X, Cham F, Bouma P, Choudhary A, Feng YR, Sanz I, Rybak S, Broder CC, Quinnan GV, Evans T, Dimitrov DS
J Immunol Methods. 2003
PubMed ID: 14659896
Differential regulation of peripheral CD4+ T cell tolerance induced by deletion and TCR revision.
Ali M, Weinreich M, Balcaitis S, Cooper CJ, Fink PJ
J Immunol. 2003
PubMed ID: 14634147
Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells.
Burchill MA, Goetz CA, Prlic M, O'Neil JJ, Harmon IR, Bensinger SJ, Turka LA, Brennan P, Jameson SC, Farrar MA
J Immunol. 2003
PubMed ID: 14634095
Requirements for T cell-polarized tubulation of class II+ compartments in dendritic cells.
Bertho N, Cerny J, Kim YM, Fiebiger E, Ploegh H, Boes M
J Immunol. 2003
PubMed ID: 14634076
Deletion of beta-catenin impairs T cell development.
Xu Y, Banerjee D, Huelsken J, Birchmeier W, Sen JM
Nat Immunol. 2003
PubMed ID: 14608382
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Human genital epithelial cells capture cell-free human immunodeficiency virus type 1 and transmit the virus to CD4+ Cells: implications for mechanisms of sexual transmission.
Wu Z, Chen Z, Phillips DM
J Infect Dis. 2003
PubMed ID: 14624372
Cutting edge: IL-16/CD4 preferentially induces Th1 cell migration: requirement of CCR5.
Lynch EA, Heijens CA, Horst NF, Center DM, Cruikshank WW
J Immunol. 2003
PubMed ID: 14607889
CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression.
Casartelli N, Di Matteo G, Potestà M, Rossi P, Doria M
J Virol. 2003
PubMed ID: 14557639
Polyclonal immunoglobulin G from patients neutralizes human immunodeficiency virus type 1 primary isolates by binding free virions, but without interfering with an initial CD4-independent attachment of the virus to primary blood mononuclear cells.
Burrer R, Haessig-Einius S, Aubertin AM, Moog C
J Virol. 2003
PubMed ID: 14557624
Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.
Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG
J Leukoc Biol. 2003
PubMed ID: 12960231
Epitope mapping and characterization of a novel CD4-induced human monoclonal antibody capable of neutralizing primary HIV-1 strains.
Xiang SH, Wang L, Abreu M, Huang CC, Kwong PD, Rosenberg E, Robinson JE, Sodroski J
Virology. 2003
PubMed ID: 14592765
The theta-defensin, retrocyclin, inhibits HIV-1 entry.
Münk C, Wei G, Yang OO, Waring AJ, Wang W, Hong T, Lehrer RI, Landau NR, Cole AM
AIDS Res Hum Retroviruses. 2003
PubMed ID: 14585219
Structural and functional characterization of the human CCR5 receptor in complex with HIV gp120 envelope glycoprotein and CD4 receptor by molecular modeling studies.
Liu S, Fan S, Sun Z
J Mol Model. 2003
PubMed ID: 14517611
Purification, characterization, and immunogenicity of a soluble trimeric envelope protein containing a partial deletion of the V2 loop derived from SF162, an R5-tropic human immunodeficiency virus type 1 isolate.
Srivastava IK, Stamatatos L, Kan E, Vajdy M, Lian Y, Hilt S, Martin L, Vita C, Zhu P, Roux KH, Vojtech L, C Montefiori D, Donnelly J, Ulmer JB, Barnett SW
J Virol. 2003
PubMed ID: 14512572
Analysis of the immunogenic properties of a single-chain polypeptide analogue of the HIV-1 gp120-CD4 complex in transgenic mice that produce human immunoglobulins.
He Y, D'Agostino P, Pinter A
Vaccine. 2003
PubMed ID: 14505925
Purified complexes of HIV-1 envelope glycoproteins with CD4 and CCR5(CXCR4): production, characterization and immunogenicity.
Xiao X, Phogat S, Shu Y, Phogat A, Chow YH, Wei OL, Goldstein H, Broder CC, Dimitrov DS
Vaccine. 2003
PubMed ID: 14505910
The di-leucine motif in the cytoplasmic tail of CD4 is not required for binding to human immunodeficiency virus type 1 Nef, but is critical for CD4 down-modulation.
Bentham M, Mazaleyrat S, Harris M
J Gen Virol. 2003
PubMed ID: 13679604
Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions.
Guo Q, Ho HT, Dicker I, Fan L, Zhou N, Friborg J, Wang T, McAuliffe BV, Wang HG, Rose RE, Fang H, Scarnati HT, Langley DR, Meanwell NA, Abraham R, Colonno RJ, Lin PF
J Virol. 2003
PubMed ID: 12970437
CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection.
Serpe CJ, Coers S, Sanders VM, Jones KJ
Brain Behav Immun. 2003
PubMed ID: 12946661
A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.
Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ
Science. 2003
PubMed ID: 14500983
Blocking the docking of HIV-1.
McKnight A, Weiss RA
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12963807
A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding.
Lin PF, Blair W, Wang T, Spicer T, Guo Q, Zhou N, Gong YF, Wang HG, Rose R, Yamanaka G, Robinson B, Li CB, Fridell R, Deminie C, Demers G, Yang Z, Zadjura L, Meanwell N, Colonno R
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12930892
Cutting Edge: Multiple autoimmune pathways in kd/kd mice.
Hancock WW, Tsai TL, Madaio MP, Gasser DL
J Immunol. 2003
PubMed ID: 12960297
Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum.
Furman MH, Loureiro J, Ploegh HL, Tortorella D
J Biol Chem. 2003
PubMed ID: 12832421
Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication.
Argañaraz ER, Schindler M, Kirchhoff F, Cortes MJ, Lama J
J Biol Chem. 2003
PubMed ID: 12816953
Binding and neutralization activity of human IgG1 and IgG3 from serum of HIV-infected individuals.
Cavacini LA, Kuhrt D, Duval M, Mayer K, Posner MR
AIDS Res Hum Retroviruses. 2003
PubMed ID: 14585209
The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4(+) T cell loss caused by the simian-human immunodeficiency virus SHIV(KU-lbMC33) in pig-tailed macaques.
Singh DK, Griffin DM, Pacyniak E, Jackson M, Werle MJ, Wisdom B, Sun F, Hout DR, Pinson DM, Gunderson RS, Powers MF, Wong SW, Stephens EB
Virology. 2003
PubMed ID: 12954211
Schwann cell chemokine receptors mediate HIV-1 gp120 toxicity to sensory neurons.
Keswani SC, Polley M, Pardo CA, Griffin JW, McArthur JC, Hoke A
Ann Neurol. 2003
PubMed ID: 12953261
Characterization of new monoclonal antibodies that discriminate between soluble and membrane CD4 and compete with human anti-CD4 autoimmune sera.
Denisova G, Lideman L, Spectorman E, Abulafia-Lapid R, Burke M, Yust I, Gershoni JM
Mol Immunol. 2003
PubMed ID: 12943795
CD25+, interleukin-10-producing CD4+ T cells are required for suppressor cell production and immune privilege in the anterior chamber of the eye.
Skelsey ME, Mayhew E, Niederkorn JY
Immunology. 2003
PubMed ID: 12941137
Virus entry as a target for anti-HIV intervention.
Esté JA
Curr Med Chem. 2003
PubMed ID: 12871111
Sequence variability analysis of human class I and class II MHC molecules: functional and structural correlates of amino acid polymorphisms.
Reche PA, Reinherz EL
J Mol Biol. 2003
PubMed ID: 12899833
Is the V3 loop involved in HIV binding to CD4?
Dettin M, Ferranti P, Scarinci C, Picariello G, Di Bello C
Biochemistry. 2003
PubMed ID: 12885233
Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo.
Matsuzaki J, Tsuji T, Chamoto K, Takeshima T, Sendo F, Nishimura T
Cell Immunol. 2003
PubMed ID: 14609575
A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels.
Gu C, Jan YN, Jan LY
Science. 2003
PubMed ID: 12893943
Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120.
Choe H, Li W, Wright PL, Vasilieva N, Venturi M, Huang CC, Grundner C, Dorfman T, Zwick MB, Wang L, Rosenberg ES, Kwong PD, Burton DR, Robinson JE, Sodroski JG, Farzan M
Cell. 2003
PubMed ID: 12887918
Vpu exerts a positive effect on HIV-1 infectivity by down-modulating CD4 receptor molecules at the surface of HIV-1-producing cells.
Levesque K, Zhao YS, Cohen EA
J Biol Chem. 2003
PubMed ID: 12746459
Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein.
Fujii S, Shimizu K, Smith C, Bonifaz L, Steinman RM
J Exp Med. 2003
PubMed ID: 12874260
Impaired arteriogenic response to acute hindlimb ischemia in CD4-knockout mice.
Stabile E, Burnett MS, Watkins C, Kinnaird T, Bachis A, la Sala A, Miller JM, Shou M, Epstein SE, Fuchs S
Circulation. 2003
PubMed ID: 12821542
HIV coreceptors: role of structure, posttranslational modifications, and internalization in viral-cell fusion and as targets for entry inhibitors.
Zaitseva M, Peden K, Golding H
Biochim Biophys Acta. 2003
PubMed ID: 12873765
Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry.
Hatse S, Princen K, Vermeire K, Gerlach LO, Rosenkilde MM, Schwartz TW, Bridger G, De Clercq E, Schols D
FEBS Lett. 2003
PubMed ID: 12832058
Downregulation of CD4 is required for maintenance of viral infectivity of HIV-1.
Tanaka M, Ueno T, Nakahara T, Sasaki K, Ishimoto A, Sakai H
Virology. 2003
PubMed ID: 12842621
CD4 dependence of gp120IIIB-CXCR4 interaction is cell-type specific.
Bodner A, Toth PT, Oh SB, Lu M, Tran PB, Chin RK, Ren D, Miller RJ
J Neuroimmunol. 2003
PubMed ID: 12864967
The fusion of IGF I with stromal cell-derived factor I or alpha1 proteinase inhibitor alters their mitogenic or chemotactic activities while keeping their ability to inhibit HIV-1-gp120 binding.
Sandoval C, Stojanova A, DiFalco MR, Congote LF
Biochem Pharmacol. 2003
PubMed ID: 12787886
A novel human antibody against human immunodeficiency virus type 1 gp120 is V1, V2, and V3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin G1 b12.
Zwick MB, Kelleher R, Jensen R, Labrijn AF, Wang M, Quinnan GV, Parren PW, Burton DR
J Virol. 2003
PubMed ID: 12768015
Cytolysis by CCR5-using human immunodeficiency virus type 1 envelope glycoproteins is dependent on membrane fusion and can be inhibited by high levels of CD4 expression.
LaBonte JA, Madani N, Sodroski J
J Virol. 2003
PubMed ID: 12767984
Expression of CD4 on human peripheral blood neutrophils.
Biswas P, Mantelli B, Sica A, Malnati M, Panzeri C, Saccani A, Hasson H, Vecchi A, Saniabadi A, Lusso P, Lazzarin A, Beretta A
Blood. 2003
PubMed ID: 12531788
Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120.
Zwick MB, Parren PW, Saphire EO, Church S, Wang M, Scott JK, Dawson PE, Wilson IA, Burton DR
J Virol. 2003
PubMed ID: 12719580
Redox-triggered infection by disulfide-shackled human immunodeficiency virus type 1 pseudovirions.
Binley JM, Cayanan CS, Wiley C, Schülke N, Olson WC, Burton DR
J Virol. 2003
PubMed ID: 12719560
Retrocyclin, an antiretroviral theta-defensin, is a lectin.
Wang W, Cole AM, Hong T, Waring AJ, Lehrer RI
J Immunol. 2003
PubMed ID: 12707350
Involvement of CD4 D3-D4 membrane proximal extracellular domain for the inhibitory effect of oxidative stress on activation-induced CD4 down-regulation and its possible role for T cell activation.
Nakamura K, Yube K, Miyatake A, Cambier JC, Hirashima M
Mol Immunol. 2003
PubMed ID: 12695117
Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry.
Tsamis F, Gavrilov S, Kajumo F, Seibert C, Kuhmann S, Ketas T, Trkola A, Palani A, Clader JW, Tagat JR, McCombie S, Baroudy B, Moore JP, Sakmar TP, Dragic T
J Virol. 2003
PubMed ID: 12692222
Immune enhancement of skin carcinogenesis by CD4+ T cells.
Daniel D, Meyer-Morse N, Bergsland EK, Dehne K, Coussens LM, Hanahan D
J Exp Med. 2003
PubMed ID: 12695493
HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.
Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M
J Biosci. 2003
PubMed ID: 12734410
The CCR5 and CXCR4 coreceptors are both used by human immunodeficiency virus type 1 primary isolates from subtype C.
Cilliers T, Nhlapo J, Coetzer M, Orlovic D, Ketas T, Olson WC, Moore JP, Trkola A, Morris L
J Virol. 2003
PubMed ID: 12634405
Conformational changes in env oligomer induced by an antibody dependent on the V3 loop base.
Cavacini L, Duval M, Song L, Sangster R, Xiang SH, Sodroski J, Posner M
AIDS. 2003
PubMed ID: 12646791
Evidence for CD4-enchanced signaling through the chemokine receptor CCR5.
Staudinger R, Phogat SK, Xiao X, Wang X, Dimitrov DS, Zolla-Pazner S
J Biol Chem. 2003
PubMed ID: 12531905
Antibody neutralization and escape by HIV-1.
Wei X, Decker JM, Wang S, Hui H, Kappes JC, Wu X, Salazar-Gonzalez JF, Salazar MG, Kilby JM, Saag MS, Komarova NL, Nowak MA, Hahn BH, Kwong PD, Shaw GM
Nature. 2003
PubMed ID: 12646921
Human immunodeficiency virus type 1 (HIV-1) induces activation of multiple STATs in CD4+ cells of lymphocyte or monocyte/macrophage lineages.
Kohler JJ, Tuttle DL, Coberley CR, Sleasman JW, Goodenow MM
J Leukoc Biol. 2003
PubMed ID: 12629155
The Tat antagonist neomycin B hexa-arginine conjugate inhibits gp-120-induced death of human neuroblastoma cells.
Catani MV, Corasaniti MT, Ranalli M, Amantea D, Litovchick A, Lapidot A, Melino G
J Neurochem. 2003
PubMed ID: 12614324
Effect of amino acid substitution of the V3 and bridging sheet residues in human immunodeficiency virus type 1 subtype C gp120 on CCR5 utilization.
Suphaphiphat P, Thitithanyanont A, Paca-Uccaralertkun S, Essex M, Lee TH
J Virol. 2003
PubMed ID: 12610158
Neutralization of human immunodeficiency virus type 1 by sCD4-17b, a single-chain chimeric protein, based on sequential interaction of gp120 with CD4 and coreceptor.
Dey B, Del Castillo CS, Berger EA
J Virol. 2003
PubMed ID: 12584309
Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection.
Shedlock DJ, Whitmire JK, Tan J, MacDonald AS, Ahmed R, Shen H
J Immunol. 2003
PubMed ID: 12574376
Reduced fitness of HIV-1 resistant to CXCR4 antagonists.
Armand-Ugón M, Quiñones-Mateu ME, Gutiérez A, Barretina J, Blanco J, Schols D, De Clercq E, Clotet B, Esté JA
Antivir Ther. 2003
PubMed ID: 12713058
Surface CD4 expression modulated by a cellular factor induced by HIV type 1 infection.
Sheeter D, Du P, Rought S, Richman D, Corbeil J
AIDS Res Hum Retroviruses. 2003
PubMed ID: 12639247
Hierarchical interactions control CD4 gene expression during thymocyte development.
Adlam M, Siu G
Immunity. 2003
PubMed ID: 12594945
A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes.
Shen H, Whitmire JK, Fan X, Shedlock DJ, Kaech SM, Ahmed R
J Immunol. 2003
PubMed ID: 12538706
Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis.
Stoddart CA, Geleziunas R, Ferrell S, Linquist-Stepps V, Moreno ME, Bare C, Xu W, Yonemoto W, Bresnahan PA, McCune JM, Greene WC
J Virol. 2003
PubMed ID: 12525647
Peptides trap the human immunodeficiency virus type 1 envelope glycoprotein fusion intermediate at two sites.
He Y, Vassell R, Zaitseva M, Nguyen N, Yang Z, Weng Y, Weiss CD
J Virol. 2003
PubMed ID: 12525600
Protein-disulfide isomerase-mediated reduction of two disulfide bonds of HIV envelope glycoprotein 120 occurs post-CXCR4 binding and is required for fusion.
Barbouche R, Miquelis R, Jones IM, Fenouillet E
J Biol Chem. 2003
PubMed ID: 12218052
Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling.
Fragoso R, Ren D, Zhang X, Su MW, Burakoff SJ, Jin YJ
J Immunol. 2003
PubMed ID: 12517957
HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages.
Freedman BD, Liu QH, Del Corno M, Collman RG
Immunol Res. 2003
PubMed ID: 12857973
HIV-1 Env-chemokine receptor interactions in primary human macrophages: entry and beyond.
Collman RG
Res Initiat Treat Action. 2003
PubMed ID: 12845769
[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]
Bénichou S, Benmerah A
Med Sci (Paris). 2003
PubMed ID: 12836198
Potential drug targets on the HIV-1 envelope glycoproteins, gp120 and gp41.
Huang L, Zhang L, Chen CH
Curr Pharm Des. 2003
PubMed ID: 12769725
Quantitative competitive reverse transcription polymerase chain reaction is not a useful method for quantification of CD4 and CD8 cell status during HIV infection.
Jaspan HB, Richard Gaumer H, Garry RF
J Negat Results Biomed. 2003
PubMed ID: 12702212
[Interaction of human apolipoprotein AI and HIV-1 envelope proteins with the native and recombinant CD4 receptors]
Panin LE, Kostina NE
Vopr Virusol. 2003
PubMed ID: 12608057
Nonneutralizing antibodies to the CD4-binding site on the gp120 subunit of human immunodeficiency virus type 1 do not interfere with the activity of a neutralizing antibody against the same site.
Herrera C, Spenlehauer C, Fung MS, Burton DR, Beddows S, Moore JP
J Virol. 2003
PubMed ID: 12502824
Identification of gp120 binding sites on CXCR4 by using CD4-independent human immunodeficiency virus type 2 Env proteins.
Lin G, Baribaud F, Romano J, Doms RW, Hoxie JA
J Virol. 2003
PubMed ID: 12502809
Superantigenic activity is responsible for induction of coronary arteritis in mice: an animal model of Kawasaki disease.
Duong TT, Silverman ED, Bissessar MV, Yeung RS
Int Immunol. 2003
PubMed ID: 12502728
Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120.
Pantophlet R, Ollmann Saphire E, Poignard P, Parren PW, Wilson IA, Burton DR
J Virol. 2003
PubMed ID: 12477867
Heterogeneity of envelope molecules expressed on primary human immunodeficiency virus type 1 particles as probed by the binding of neutralizing and nonneutralizing antibodies.
Poignard P, Moulard M, Golez E, Vivona V, Franti M, Venturini S, Wang M, Parren PW, Burton DR
J Virol. 2003
PubMed ID: 12477840
Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry.
Gallina A, Hanley TM, Mandel R, Trahey M, Broder CC, Viglianti GA, Ryser HJ
J Biol Chem. 2002
PubMed ID: 12218051
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.
Kontoyiannis D, Boulougouris G, Manoloukos M, Armaka M, Apostolaki M, Pizarro T, Kotlyarov A, Forster I, Flavell R, Gaestel M, Tsichlis P, Cominelli F, Kollias G
J Exp Med. 2002
PubMed ID: 12486099
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
A new possible mechanism of human immunodeficiency virus type 1 infection of neural cells.
Alvarez Losada S, Cantó-Nogués C, Muñoz-Fernández MA
Neurobiol Dis. 2002
PubMed ID: 12586555
CD4 dimers constitute the functional component required for T cell activation.
Moldovan MC, Yachou A, Lévesque K, Wu H, Hendrickson WA, Cohen EA, Sékaly RP
J Immunol. 2002
PubMed ID: 12444132
Human immunodeficiency virus envelope (gp120) binding to DC-SIGN and primary dendritic cells is carbohydrate dependent but does not involve 2G12 or cyanovirin binding sites: implications for structural analyses of gp120-DC-SIGN binding.
Hong PW, Flummerfelt KB, de Parseval A, Gurney K, Elder JH, Lee B
J Virol. 2002
PubMed ID: 12438611
A post-CD4-binding step involving interaction of the V3 region of viral gp120 with host cell surface glycosphingolipids is common to entry and infection by diverse HIV-1 strains.
Nehete PN, Vela EM, Hossain MM, Sarkar AK, Yahi N, Fantini J, Sastry KJ
Antiviral Res. 2002
PubMed ID: 12406507
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.
Taniuchi I, Osato M, Egawa T, Sunshine MJ, Bae SC, Komori T, Ito Y, Littman DR
Cell. 2002
PubMed ID: 12464175
Low levels of co-receptor CCR5 are sufficient to permit HIV envelope-mediated fusion with resting CD4 T cells.
Chanel C, Staropoli I, Baleux F, Amara A, Valenzuela-Fernandez A, Virelizier JL, Arenzana-Seisdedos F, Altmeyer R
AIDS. 2002
PubMed ID: 12441808
A unique mechanism for innate cytokine promotion of T cell responses to viral infections.
Pien GC, Nguyen KB, Malmgaard L, Satoskar AR, Biron CA
J Immunol. 2002
PubMed ID: 12421964
HLA-DQ determines the response to exogenous wheat proteins: a model of gluten sensitivity in transgenic knockout mice.
Black KE, Murray JA, David CS
J Immunol. 2002
PubMed ID: 12421937
Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3.
Workman CJ, Dugger KJ, Vignali DA
J Immunol. 2002
PubMed ID: 12421911
Characterization of CD4-induced epitopes on the HIV type 1 gp120 envelope glycoprotein recognized by neutralizing human monoclonal antibodies.
Xiang SH, Doka N, Choudhary RK, Sodroski J, Robinson JE
AIDS Res Hum Retroviruses. 2002
PubMed ID: 12487827
Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation.
Taniuchi I, Sunshine MJ, Festenstein R, Littman DR
Mol Cell. 2002
PubMed ID: 12453416
Multiple determinants are involved in HIV coreceptor use as demonstrated by CCR4/CCL22 interaction in peripheral blood mononuclear cells (PBMCs).
Agrawal L, Vanhorn-Ali Z, Alkhatib G
J Leukoc Biol. 2002
PubMed ID: 12429730
Restricted replication of primary HIV-1 isolates using both CCR5 and CXCR4 in Th2 but not in Th1 CD4(+) T cells.
Vicenzi E, Panina-Bodignon P, Vallanti G, Di Lucia P, Poli G
J Leukoc Biol. 2002
PubMed ID: 12429712
Functional reconstitution of the HIV receptors CCR5 and CD4 in liposomes.
Devesa F, Chams V, Dinadayala P, Stella A, Ragas A, Auboiroux H, Stegmann T, Poquet Y
Eur J Biochem. 2002
PubMed ID: 12392548
Identification of conserved and variable structures in the human immunodeficiency virus gp120 glycoprotein of importance for CXCR4 binding.
Basmaciogullari S, Babcock GJ, Van Ryk D, Wojtowicz W, Sodroski J
J Virol. 2002
PubMed ID: 12368322
Engineered CD4- and CXCR4-using simian immunodeficiency virus from African green monkeys is neutralization sensitive and replicates in nonstimulated lymphocytes.
König RR, Flory E, Steidl S, Neumann J, Coulibaly C, Holznagel E, Holzammer S, Norley S, Cichutek K
J Virol. 2002
PubMed ID: 12368305
Human CD4 expression at the late single-positive stage of thymic development supports T cell maturation and peripheral export in CD4-deficient mice.
Boyer O, Marodon G, Cohen JL, Lejeune L, Irinopoulou T, Liblau R, Bruneval P, Klatzmann D
J Immunol. 2002
PubMed ID: 12370367
Functional CXCR4 receptor development parallels sensitivity to HIV-1 gp120 in cultured rat astroglial cells but not in cultured rat cortical neurons.
Köller H, Schaal H, Rosenbaum C, Czardybon M, Von Giesen HJ, Müller HW, Arendt G
J Neurovirol. 2002
PubMed ID: 12402167
The chicken CD4 gene has remained conserved in evolution.
Koskinen R, Salomonsen J, Tregaskes CA, Young JR, Goodchild M, Bumstead N, Vainio O
Immunogenetics. 2002
PubMed ID: 12389100
Mice deficient in perforin, CD4+ T cells, or CD28-mediated signaling maintain the typical immunodominance hierarchies of CD8+ T-cell responses to influenza virus.
Chen W, Bennink JR, Morton PA, Yewdell JW
J Virol. 2002
PubMed ID: 12239309
Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein.
Xiang SH, Kwong PD, Gupta R, Rizzuto CD, Casper DJ, Wyatt R, Wang L, Hendrickson WA, Doyle ML, Sodroski J
J Virol. 2002
PubMed ID: 12208966
Anti-human CD4 induces peripheral tolerance in a human CD4+, murine CD4-, HLA-DR+ advanced transgenic mouse model.
Laub R, Brecht R, Dorsch M, Valey U, Wenk K, Emmrich F
J Immunol. 2002
PubMed ID: 12218108
CD4 is active as a signaling molecule on the human monocytic cell line Thp-1.
Graziani-Bowering G, Filion LG, Thibault P, Kozlowski M
Exp Cell Res. 2002
PubMed ID: 12213222
CD4 and CD8 T cells, but not B cells, are critical to the control of murine experimental autoimmune neuritis.
Zhu Y, Bao L, Zhu S, Chen Z, van der Meide P, Nennesmo I, Winblad B, Ljunggren HG, Zhu J
Exp Neurol. 2002
PubMed ID: 12429233
Editing autoreactive TCR enables efficient positive selection.
Santori FR, Arsov I, Lilić M, Vukmanović S, Lili M
J Immunol. 2002
PubMed ID: 12165493
Blocking of HIV-1 infection by targeting CD4 to nonraft membrane domains.
Del Real G, Jiménez-Baranda S, Lacalle RA, Mira E, Lucas P, Gómez-Moutón C, Carrera AC, Martínez-A C, Mañes S
J Exp Med. 2002
PubMed ID: 12163558
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2.
Malek TR, Yu A, Vincek V, Scibelli P, Kong L
Immunity. 2002
PubMed ID: 12196288
Expression of the human CD4 receptor is sufficient for the transduction of murine T-cells with MLV/HIV pseudotyped vectors.
Mitnacht-Kraus R, Schnierle B
Virus Res. 2002
PubMed ID: 12191776
MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses.
VanLith ML, Kohlgraf KG, Sivinski CL, Tempero RM, Hollingsworth MA
Int Immunol. 2002
PubMed ID: 12147624
Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope.
Castedo M, Roumier T, Blanco J, Ferri KF, Barretina J, Tintignac LA, Andreau K, Perfettini JL, Amendola A, Nardacci R, Leduc P, Ingber DE, Druillennec S, Roques B, Leibovitch SA, Vilella-Bach M, Chen J, Este JA, Modjtahedi N, Piacentini M, Kroemer G
EMBO J. 2002
PubMed ID: 12145207
High levels of antibodies to the CD4 binding domain of human immunodeficiency virus type 1 glycoprotein 120 are associated with faster disease progression.
Chien PC, Cohen S, Kleeberger C, Giorgi J, Phair J, Zolla-Pazner S, Hioe CE
J Infect Dis. 2002
PubMed ID: 12134256
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.
Chi TH, Wan M, Zhao K, Taniuchi I, Chen L, Littman DR, Crabtree GR
Nature. 2002
PubMed ID: 12110891
The role of structural and functional homology between human apolipoprotein A-I and envelope proteins of human immunodeficiency virus type 1 in CD4 receptor binding.
Panin LE, Kostina NE, Lukashev VA
Dokl Biochem Biophys. 2002
PubMed ID: 12462973
Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy.
Greene WC, Peterlin BM
Nat Med. 2002
PubMed ID: 12091904
The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.
Sanders RW, Venturi M, Schiffner L, Kalyanaraman R, Katinger H, Lloyd KO, Kwong PD, Moore JP
J Virol. 2002
PubMed ID: 12072528
CD4-Lck through TCR and in the absence of Vav exchange factor induces Bax increase and mitochondrial damage.
Tuosto L, Marinari B, Piccolella E
J Immunol. 2002
PubMed ID: 12055221
Beta-turn Phe in HIV-1 Env binding site of CD4 and CD4 mimetic miniprotein enhances Env binding affinity but is not required for activation of co-receptor/17b site.
Dowd CS, Leavitt S, Babcock G, Godillot AP, Van Ryk D, Canziani GA, Sodroski J, Freire E, Chaiken IM
Biochemistry. 2002
PubMed ID: 12033937
Ligation of human CD4 interferes with antigen-induced activation of primary T cells.
Marschner S, Hünig T, Cambier JC, Finkel TH
Immunol Lett. 2002
PubMed ID: 12008044
Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo.
Trcka J, Moroi Y, Clynes RA, Goldberg SM, Bergtold A, Perales MA, Ma M, Ferrone CR, Carroll MC, Ravetch JV, Houghton AN
Immunity. 2002
PubMed ID: 12121667
CD4 and CD8 T cells in susceptibility/protection to collagen-induced arthritis in HLA-DQ8-transgenic mice: implications for rheumatoid arthritis.
Taneja V, Taneja N, Paisansinsup T, Behrens M, Griffiths M, Luthra H, David CS
J Immunol. 2002
PubMed ID: 12023391
Involvement of integrin alphavbeta3 in the pathogenesis of human immunodeficiency virus type 1 infection in monocytes.
Lafrenie RM, Lee SF, Hewlett IK, Yamada KM, Dhawan S
Virology. 2002
PubMed ID: 12083833
CXCR4/CCR5 down-modulation and chemotaxis are regulated by the proteasome pathway.
Fernandis AZ, Cherla RP, Chernock RD, Ganju RK
J Biol Chem. 2002
PubMed ID: 11877445
Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis.
Habasque C, Aubry F, Jégou B, Samson M
Mol Hum Reprod. 2002
PubMed ID: 11994538
Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptors for productive entry into CD4(+) T cells.
Popik W, Alce TM, Au WC
J Virol. 2002
PubMed ID: 11967288
CD4(+) T cell-dependent airway mucus production occurs in response to IL-5 expression in lung.
Justice JP, Crosby J, Borchers MT, Tomkinson A, Lee JJ, Lee NA
Am J Physiol Lung Cell Mol Physiol. 2002
PubMed ID: 11943672
Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes.
Lundquist CA, Tobiume M, Zhou J, Unutmaz D, Aiken C
J Virol. 2002
PubMed ID: 11932428
NF-kappaB activation upon interaction of HIV-1 envelope glycoproteins with cell surface CD4 involves IkappaB kinases.
Bossis G, Salinas S, Cartier C, Devaux C, Briant L
FEBS Lett. 2002
PubMed ID: 11959143
Presence of a helix in human CD4 cytoplasmic domain promotes binding to HIV-1 Nef protein.
Preusser A, Briese L, Willbold D
Biochem Biophys Res Commun. 2002
PubMed ID: 11922627
The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling.
Hawash IY, Hu XE, Adal A, Cassady JM, Geahlen RL, Harrison ML
Biochim Biophys Acta. 2002
PubMed ID: 12007789
HIV receptors and cellular tropism.
Weiss RA
IUBMB Life. 2002
PubMed ID: 12120995
Expression of lineage markers by CD34+ hematopoietic stem cells of adult mice.
Ishida A, Zeng H, Ogawa M
Exp Hematol. 2002
PubMed ID: 11937272
Killing of naive T cells by CD95L-transfected dendritic cells (DC): in vivo study using killer DC-DC hybrids and CD4(+) T cells from DO11.10 mice.
Kusuhara M, Matsue K, Edelbaum D, Loftus J, Takashima A, Matsue H
Eur J Immunol. 2002
PubMed ID: 11920570
Regulation of CC chemokine receptor 5 and CD4 expression and human immunodeficiency virus type 1 replication in human macrophages and microglia by T helper type 2 cytokines.
Wang J, Crawford K, Yuan M, Wang H, Gorry PR, Gabuzda D
J Infect Dis. 2002
PubMed ID: 11920312
A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Delta32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4.
Naif HM, Cunningham AL, Alali M, Li S, Nasr N, Buhler MM, Schols D, de Clercq E, Stewart G
J Virol. 2002
PubMed ID: 11884536
Role of CD4 hinge region in GP120 utilization by immunoglobulin domain 1.
Murray JL, Hu QX, Navenot JM, Peiper SC
Biochem Biophys Res Commun. 2002
PubMed ID: 11906183
Kappa-opioid receptor agonist inhibition of HIV-1 envelope glycoprotein-mediated membrane fusion and CXCR4 expression on CD4(+) lymphocytes.
Lokensgard JR, Gekker G, Peterson PK
Biochem Pharmacol. 2002
PubMed ID: 11931835
HIV-1 encoded virus protein U (Vpu) solution structure of the 41-62 hydrophilic region containing the phosphorylated sites Ser52 and Ser56.
Coadou G, Evrard-Todeschi N, Gharbi-Benarous J, Benarous R, Girault JP
Int J Biol Macromol. 2002
PubMed ID: 11893391
CD4 is required for the development of a protective granulomatous response to pulmonary tuberculosis.
Saunders BM, Frank AA, Orme IM, Cooper AM
Cell Immunol. 2002
PubMed ID: 12381351
An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis.
Edling AE, Choksi S, Huang Z, Korngold R
J Autoimmun. 2002
PubMed ID: 11908949
CCR5 and CXCR4 usage by non-clade B human immunodeficiency virus type 1 primary isolates.
Thompson DA, Cormier EG, Dragic T
J Virol. 2002
PubMed ID: 11861874
Truncation of the cytoplasmic domain induces exposure of conserved regions in the ectodomain of human immunodeficiency virus type 1 envelope protein.
Edwards TG, Wyss S, Reeves JD, Zolla-Pazner S, Hoxie JA, Doms RW, Baribaud F
J Virol. 2002
PubMed ID: 11861835
p56Lck anchors CD4 to distinct microdomains on microvilli.
Foti M, Phelouzat MA, Holm A, Rasmusson BJ, Carpentier JL
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11854499
Characterization of the tertiary structure of soluble CD4 bound to glycosylated full-length HIVgp120 by chemical modification of arginine residues and mass spectrometric analysis.
Hager-Braun C, Tomer KB
Biochemistry. 2002
PubMed ID: 11827520
Expression and functional activity of CXCR-4 and CCR-5 chemokine receptors in human thymocytes.
Zamarchi R, Allavena P, Borsetti A, Stievano L, Tosello V, Marcato N, Esposito G, Roni V, Paganin C, Bianchi G, Titti F, Verani P, Gerosa G, Amadori A
Clin Exp Immunol. 2002
PubMed ID: 11876757
Adapters in lymphocyte signaling.
Leo A, Wienands J, Baier G, Horejsi V, Schraven B
J Clin Invest. 2002
PubMed ID: 11827988
Segregation of CD4 and CXCR4 into distinct lipid microdomains in T lymphocytes suggests a mechanism for membrane destabilization by human immunodeficiency virus.
Kozak SL, Heard JM, Kabat D
J Virol. 2002
PubMed ID: 11799176
Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells.
Cortés MJ, Wong-Staal F, Lama J
J Biol Chem. 2002
PubMed ID: 11704677
Allergic inflammatory response to short ragweed allergenic extract in HLA-DQ transgenic mice lacking CD4 gene.
Chapoval SP, Iijima K, Marietta EV, Smart MK, Chapoval AI, Andrews AG, David CS
J Immunol. 2002
PubMed ID: 11777987
The role of the CD4 receptor versus HIV coreceptors in envelope-mediated apoptosis in peripheral blood mononuclear cells.
Arthos J, Cicala C, Selig SM, White AA, Ravindranath HM, Van Ryk D, Steenbeke TD, Machado E, Khazanie P, Hanback MS, Hanback DB, Rabin RL, Fauci AS
Virology. 2002
PubMed ID: 11878912
Human immunodeficiency virus type 1 neutralization by a single molecule of V3-targeted antibody.
Harada S
Microbiol Immunol. 2002
PubMed ID: 12597360
Preferential attachment of HIV particles to activated and CD45RO+CD4+ T cells.
Blanco J, Barretina J, Gutiérrez A, Armand-Ugón M, Cabrera C, Clotet B, Esté JA
AIDS Res Hum Retroviruses. 2002
PubMed ID: 11804554
Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor.
Kitchen SG, LaForge S, Patel VP, Kitchen CM, Miceli MC, Zack JA
Blood. 2002
PubMed ID: 11756173
The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step.
Papandréou MJ, Barbouche R, Guieu R, Kieny MP, Fenouillet E
Mol Pharmacol. 2002
PubMed ID: 11752220
Ectopic expression of IL-5 identifies an additional CD4(+) T cell mechanism of airway eosinophil recruitment.
Crosby JR, Shen HH, Borchers MT, Justice JP, Ansay T, Lee JJ, Lee NA
Am J Physiol Lung Cell Mol Physiol. 2002
PubMed ID: 11741821
The role of the third beta strand in gp120 conformation and neutralization sensitivity of the HIV-1 primary isolate DH012.
Zhu CB, Zhu L, Holz-Smith S, Matthews TJ, Chen CH
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11734627
Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 gene.
Wang Q, Strong J, Killeen N
J Exp Med. 2001
PubMed ID: 11748274
CD4(+) T cells are required for the development of cytotoxic CD8(+) T cells during Mycobacterium tuberculosis infection.
Serbina NV, Lazarevic V, Flynn JL
J Immunol. 2001
PubMed ID: 11739519
Lineage fate alteration of thymocytes developing in an MHC environment containing MHC/peptide ligands with antagonist properties.
Barthlott T, Stockinger B
Eur J Immunol. 2001
PubMed ID: 11745379
cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor.
Lee B, Leslie G, Soilleux E, O'Doherty U, Baik S, Levroney E, Flummerfelt K, Swiggard W, Coleman N, Malim M, Doms RW
J Virol. 2001
PubMed ID: 11711593
Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment.
Leung RK, Thomson K, Gallimore A, Jones E, Van den Broek M, Sierro S, Alsheikhly AR, McMichael A, Rahemtulla A
Nat Immunol. 2001
PubMed ID: 11694883
Role for T cell-independent B cell activity in the resolution of primary rotavirus infection in mice.
VanCott JL, McNeal MM, Flint J, Bailey SA, Choi AH, Ward RL
Eur J Immunol. 2001
PubMed ID: 11745356
Abundance of unconventional CD8(+) natural killer T cells in the large intestine.
Bannai M, Kawamura T, Naito T, Kameyama H, Abe T, Kawamura H, Tsukada C, Watanabe H, Hatakeyama K, Hamada H, Nishiyama Y, Ishikawa H, Takeda K, Okumura K, Taniguchi M, Abo T
Eur J Immunol. 2001
PubMed ID: 11745354
Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure.
Burne MJ, Daniels F, El Ghandour A, Mauiyyedi S, Colvin RB, O'Donnell MP, Rabb H
J Clin Invest. 2001
PubMed ID: 11696572
Requirements for allergen-induced airway inflammation and hyperreactivity in CD4-deficient and CD4-sufficient HLA-DQ transgenic mice.
Chapoval SP, Marietta EV, Smart MK, David CS
J Allergy Clin Immunol. 2001
PubMed ID: 11692102
Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage.
Zou YR, Sunshine MJ, Taniuchi I, Hatam F, Killeen N, Littman DR
Nat Genet. 2001
PubMed ID: 11687799
Genetic and functional analysis of the human immunodeficiency virus (HIV) type 1-inhibiting F12-HIVnef allele.
D'Aloja P, Santarcangelo AC, Arold S, Baur A, Federico M
J Gen Virol. 2001
PubMed ID: 11602785
CD4(+) T cells induced by a DNA vaccine: immunological consequences of epitope-specific lysosomal targeting.
Rodriguez F, Harkins S, Redwine JM, de Pereda JM, Whitton JL
J Virol. 2001
PubMed ID: 11581410
CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo.
Glushakova S, Münch J, Carl S, Greenough TC, Sullivan JL, Margolis L, Kirchhoff F
J Virol. 2001
PubMed ID: 11581379
Ligand binding characteristics of CXCR4 incorporated into paramagnetic proteoliposomes.
Babcock GJ, Mirzabekov T, Wojtowicz W, Sodroski J
J Biol Chem. 2001
PubMed ID: 11489906
Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation.
Castedo M, Ferri KF, Blanco J, Roumier T, Larochette N, Barretina J, Amendola A, Nardacci R, Métivier D, Este JA, Piacentini M, Kroemer G
J Exp Med. 2001
PubMed ID: 11602639
Cockroach allergen-induced eosinophilic airway inflammation in HLA-DQ/human CD4(+) transgenic mice.
Papouchado BG, Chapoval SP, Marietta EV, Weiler CR, David CS
J Immunol. 2001
PubMed ID: 11591792
CD4 promotes breadth in the TCR repertoire.
Wang Q, Malherbe L, Zhang D, Zingler K, Glaichenhaus N, Killeen N
J Immunol. 2001
PubMed ID: 11591754
Deletion of N-terminal myristoylation site of HIV Nef abrogates both MHC-1 and CD4 down-regulation.
Peng B, Robert-Guroff M
Immunol Lett. 2001
PubMed ID: 11578695
Distinct regulatory elements are required for faithful expression of human CD4 in T cells, macrophages, and dendritic cells of transgenic mice.
Hanna Z, Rebai N, Poudrier J, Jolicoeur P
Blood. 2001
PubMed ID: 11568018
Additive effects characterize the interaction of antibodies involved in neutralization of the primary dualtropic human immunodeficiency virus type 1 isolate 89.6.
Verrier F, Nádas A, Gorny MK, Zolla-Pazner S
J Virol. 2001
PubMed ID: 11533181
Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule.
Wang JH, Meijers R, Xiong Y, Liu JH, Sakihama T, Zhang R, Joachimiak A, Reinherz EL
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11535811
Intrinsic AHR in IL-5 transgenic mice is dependent on CD4(+) cells and CD49d-mediated signaling.
Borchers MT, Crosby J, Justice P, Farmer S, Hines E, Lee JJ, Lee NA
Am J Physiol Lung Cell Mol Physiol. 2001
PubMed ID: 11504693
HIV Nef-mediated cellular phenotypes are differentially expressed as a function of intracellular Nef concentrations.
Liu X, Schrager JA, Lange GD, Marsh JW
J Biol Chem. 2001
PubMed ID: 11438519
HIV envelope gp120 activates human arterial smooth muscle cells.
Schecter AD, Berman AB, Yi L, Mosoian A, McManus CM, Berman JW, Klotman ME, Taubman MB
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11504923
Early intermediates in HIV-1 envelope glycoprotein-mediated fusion triggered by CD4 and co-receptor complexes.
Dimitrov AS, Xiao X, Dimitrov DS, Blumenthal R
J Biol Chem. 2001
PubMed ID: 11397808
Formation of HIV-1 envelope-hepatitis B core antigen hybrids with high affinity for CD4.
Patterson LJ, Aberdeen A, Kone J, Haben M, Raymond M, Berkower I
Biochem Biophys Res Commun. 2001
PubMed ID: 11453640
Structure--function relationships in HIV-1 Nef.
Geyer M, Fackler OT, Peterlin BM
EMBO Rep. 2001
PubMed ID: 11463741
Influence of CD4 or CD8 deficiency on collagen-induced arthritis.
Ehinger M, Vestberg M, Johansson AC, Johannesson M, Svensson A, Holmdahl R
Immunology. 2001
PubMed ID: 11454058
Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus.
Patterson S, Rae A, Hockey N, Gilmour J, Gotch F
J Virol. 2001
PubMed ID: 11413340
Identification and characterization of a peptide that specifically binds the human, broadly neutralizing anti-human immunodeficiency virus type 1 antibody b12.
Zwick MB, Bonnycastle LL, Menendez A, Irving MB, Barbas CF, Parren PW, Burton DR, Scott JK
J Virol. 2001
PubMed ID: 11413337
Structural flexibility and functional valence of CD4-IgG2 (PRO 542): potential for cross-linking human immunodeficiency virus type 1 envelope spikes.
Zhu P, Olson WC, Roux KH
J Virol. 2001
PubMed ID: 11413335
Target cell populations of human immunodeficiency virus type 1 in peripheral blood lymphocytes with different chemokine receptors at various stages of disease progression.
Auewarakul P, Sangsiriwut K, Suwanagool S, Wasi C
J Virol. 2001
PubMed ID: 11413305
HIV envelope proteins differentially utilize CXCR4 and CCR5 coreceptors for induction of apoptosis.
Yao Q, Compans RW, Chen C
Virology. 2001
PubMed ID: 11414813
Differential effects of primary human immunodeficiency virus type 1 nef sequences on downregulation of CD4 and MHC class I.
Yoon K, Jeong JG, Yoon H, Lee JS, Kim S
Biochem Biophys Res Commun. 2001
PubMed ID: 11396948
The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.
Kirchgessner H, Dietrich J, Scherer J, Isomäki P, Korinek V, Hilgert I, Bruyns E, Leo A, Cope AP, Schraven B
J Exp Med. 2001
PubMed ID: 11390434
Antigenic variation within the CD4 binding site of human immunodeficiency virus type 1 gp120: effects on chemokine receptor utilization.
Hammond AL, Lewis J, May J, Albert J, Balfe P, McKeating JA
J Virol. 2001
PubMed ID: 11356967
Mapping the determinants of the CCR5 amino-terminal sulfopeptide interaction with soluble human immunodeficiency virus type 1 gp120-CD4 complexes.
Cormier EG, Tran DN, Yukhayeva L, Olson WC, Dragic T
J Virol. 2001
PubMed ID: 11356961
Identification of two sequences in the cytoplasmic tail of the human immunodeficiency virus type 1 envelope glycoprotein that inhibit cell surface expression.
Bültmann A, Muranyi W, Seed B, Haas J
J Virol. 2001
PubMed ID: 11333908
Relationships between CD4 independence, neutralization sensitivity, and exposure of a CD4-induced epitope in a human immunodeficiency virus type 1 envelope protein.
Edwards TG, Hoffman TL, Baribaud F, Wyss S, LaBranche CC, Romano J, Adkinson J, Sharron M, Hoxie JA, Doms RW
J Virol. 2001
PubMed ID: 11333905
T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia.
Huber SA, Sakkinen P, David C, Newell MK, Tracy RP
Circulation. 2001
PubMed ID: 11382732
Neuraminidase from a bacterial source enhances both HIV-1-mediated syncytium formation and the virus binding/entry process.
Sun J, Barbeau B, Sato S, Tremblay MJ
Virology. 2001
PubMed ID: 11352665
CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway.
Guo Z, Meng L, Kim O, Wang J, Hart J, He G, Alegre ML, Thistlethwaite JR, Pearson TC, Larsen CP, Newell KA
Transplantation. 2001
PubMed ID: 11403253
B cell immunodeficiency fails to develop in CD4-deficient mice infected with BM5: murine AIDS as a multistep disease.
Harris DP, Koch S, Mullen LM, Swain SL
J Immunol. 2001
PubMed ID: 11342621
Replacement of the V3 region of gp120 with SDF-1 preserves the infectivity of T-cell line-tropic human immunodeficiency virus type 1.
Yonezawa A, Hori T, Takaori-Kondo A, Morita R, Uchiyama T
J Virol. 2001
PubMed ID: 11287575
Short peptides with induced beta-turn inhibit the interaction between HIV-1 gp120 and CD4.
Choi YH, Rho WS, Kim ND, Park SJ, Shin DH, Kim JW, Im SH, Won HS, Lee CW, Chae CB, Sung YC
J Med Chem. 2001
PubMed ID: 11311058
Human immunodeficiency virus type 1 clade A and D neurotropism: molecular evolution, recombination, and coreceptor use.
Zhang K, Hawken M, Rana F, Welte FJ, Gartner S, Goldsmith MA, Power C
Virology. 2001
PubMed ID: 11312658
A CCR5-dependent novel mechanism for type 1 HIV gp120 induced loss of macrophage cell surface CD4.
Hewson TJ, Logie JJ, Simmonds P, Howie SE
J Immunol. 2001
PubMed ID: 11290759
Use of human CD4 transgenic mice for studying immunogenicity of HIV-1 envelope protein gp120.
Seagal J, Spectorman E, Gershoni JM, Denisova GF
Transgenic Res. 2001
PubMed ID: 11305358
Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP.
Janvier K, Craig H, Le Gall S, Benarous R, Guatelli J, Schwartz O, Benichou S
J Virol. 2001
PubMed ID: 11264386
Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain.
Preusser A, Briese L, Baur AS, Willbold D
J Virol. 2001
PubMed ID: 11264384
CCR5, CXCR4, and CD4 are clustered and closely apposed on microvilli of human macrophages and T cells.
Singer II, Scott S, Kawka DW, Chin J, Daugherty BL, DeMartino JA, DiSalvo J, Gould SL, Lineberger JE, Malkowitz L, Miller MD, Mitnaul L, Siciliano SJ, Staruch MJ, Williams HR, Zweerink HJ, Springer MS
J Virol. 2001
PubMed ID: 11264367
Loss of a single N-linked glycan allows CD4-independent human immunodeficiency virus type 1 infection by altering the position of the gp120 V1/V2 variable loops.
Kolchinsky P, Kiprilov E, Bartley P, Rubinstein R, Sodroski J
J Virol. 2001
PubMed ID: 11238869
Cloning of ACP33 as a novel intracellular ligand of CD4.
Zeitlmann L, Sirim P, Kremmer E, Kolanus W
J Biol Chem. 2001
PubMed ID: 11113139
Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis.
Honda K, Nakano H, Yoshida H, Nishikawa S, Rennert P, Ikuta K, Tamechika M, Yamaguchi K, Fukumoto T, Chiba T, Nishikawa SI
J Exp Med. 2001
PubMed ID: 11238592
The roles of MHC class II, CD40, and B7 costimulation in CTL induction by plasmid DNA.
Chan K, Lee DJ, Schubert A, Tang CM, Crain B, Schoenberger SP, Corr M
J Immunol. 2001
PubMed ID: 11207256
Impaired survival of T helper cells in the absence of CD4.
Strong J, Wang Q, Killeen N
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11226279
T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.
Xiong Y, Kern P, Chang H, Reinherz E
J Biol Chem. 2001
PubMed ID: 11106664
CD4+ and CD8+ T cell priming for contact hypersensitivity occurs independently of CD40-CD154 interactions.
Gorbachev AV, Heeger PS, Fairchild RL
J Immunol. 2001
PubMed ID: 11160289
Antibody 17b binding at the coreceptor site weakens the kinetics of the interaction of envelope glycoprotein gp120 with CD4.
Zhang W, Godillot AP, Wyatt R, Sodroski J, Chaiken I
Biochemistry. 2001
PubMed ID: 11327825
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Activation of Valpha14(+) natural killer T cells by alpha-galactosylceramide results in development of Th1 response and local host resistance in mice infected with Cryptococcus neoformans.
Kawakami K, Kinjo Y, Yara S, Koguchi Y, Uezu K, Nakayama T, Taniguchi M, Saito A
Infect Immun. 2001
PubMed ID: 11119508
Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4, KO, and CD8 KO mice.
Bumgardner GL, Gao D, Li J, Baskin JH, Heininger M, Orosz CG
Transplantation. 2000
PubMed ID: 11152110
Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates.
Kwong PD, Wyatt R, Majeed S, Robinson J, Sweet RW, Sodroski J, Hendrickson WA
Structure. 2000
PubMed ID: 11188697
CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplants.
Fischbein MP, Ardehali A, Yun J, Schoenberger S, Laks H, Irie Y, Dempsey P, Cheng G, Fishbein MC, Bonavida B
J Immunol. 2000
PubMed ID: 11120867
Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells.
Hayashi K, Natsume W, Watanabe T, Abe N, Iwai N, Okada H, Ito Y, Asano M, Iwakura Y, Habu S, Takahama Y, Satake M
J Immunol. 2000
PubMed ID: 11120804
CD4+ Th1 and CD8+ type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity.
Wang B, Fujisawa H, Zhuang L, Freed I, Howell BG, Shahid S, Shivji GM, Mak TW, Sauder DN
J Immunol. 2000
PubMed ID: 11120799
A multiple transgenic mouse model with a partially humanized activation pathway for helper T cell responses.
Laub R, Dorsch M, Meyer D, Ermann J, Hedrich HJ, Emmrich F
J Immunol Methods. 2000
PubMed ID: 11121545
Desensitization of CXC chemokine receptor 4, mediated by IL-16/CD4, is independent of p56lck enzymatic activity.
Van Drenth C, Jenkins A, Ledwich L, Ryan TC, Mashikian MV, Brazer W, Center DM, Cruikshank WW
J Immunol. 2000
PubMed ID: 11086073
The N-terminal V3 loop glycan modulates the interaction of clade A and B human immunodeficiency virus type 1 envelopes with CD4 and chemokine receptors.
Malenbaum SE, Yang D, Cavacini L, Posner M, Robinson J, Cheng-Mayer C
J Virol. 2000
PubMed ID: 11069996
Molecular function of the CD4 D1 domain in coreceptor-mediated entry by HIV type 1.
Esser U, Speck RF, Deen KC, Atchison RE, Sweet R, Goldsmith MA
AIDS Res Hum Retroviruses. 2000
PubMed ID: 11118070
A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.
Comings DE, Gade-Andavolu R, Gonzalez N, Wu S, Muhleman D, Blake H, Mann MB, Dietz G, Saucier G, MacMurray JP
Clin Genet. 2000
PubMed ID: 11140838
CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling.
Hida S, Ogasawara K, Sato K, Abe M, Takayanagi H, Yokochi T, Sato T, Hirose S, Shirai T, Taki S, Taniguchi T
Immunity. 2000
PubMed ID: 11114377
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions.
Blazar BR, Lees CJ, Martin PJ, Noelle RJ, Kwon B, Murphy W, Taylor PA
J Immunol. 2000
PubMed ID: 11046015
Heterogeneous spectrum of coreceptor usage among variants within a dualtropic human immunodeficiency virus type 1 primary-isolate quasispecies.
Singh A, Collman RG
J Virol. 2000
PubMed ID: 11024154
Impairment of human immunodeficiency virus type 1 (HIV-1) entry into Jurkat T cells by constitutive expression of the HIV-1 vpr protein: role of CD4 down-modulation.
Conti L, Varano B, Gauzzi MC, Matarrese P, Federico M, Malorni W, Belardelli F, Gessani S
J Virol. 2000
PubMed ID: 11024150
Membrane interactions and alignment of structures within the HIV-1 Vpu cytoplasmic domain: effect of phosphorylation of serines 52 and 56.
Henklein P, Kinder R, Schubert U, Bechinger B
FEBS Lett. 2000
PubMed ID: 11024464
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
The mechanism of phospholipase C-gamma1 regulation.
Kim MJ, Kim E, Ryu SH, Suh PG
Exp Mol Med. 2000
PubMed ID: 11048639
The CD4-mediated immune response is critical in determining the outcome of infection using Theiler's viruses with VP1 capsid protein point mutations.
Rodriguez M, Roos RP, McGavern D, Zoecklein L, Pavelko K, Sang H, Lin X
Virology. 2000
PubMed ID: 11017783
CD4(+) v(alpha)14 NKT cells play a crucial role in an early stage of protective immunity against infection with Leishmania major.
Ishikawa H, Hisaeda H, Taniguchi M, Nakayama T, Sakai T, Maekawa Y, Nakano Y, Zhang M, Zhang T, Nishitani M, Takashima M, Himeno K
Int Immunol. 2000
PubMed ID: 10967021
Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in mice.
Rabb H, Daniels F, O'Donnell M, Haq M, Saba SR, Keane W, Tang WW
Am J Physiol Renal Physiol. 2000
PubMed ID: 10966932
CD8+ T cells are necessary for recognition of allelic, but not locus-mismatched or xeno-, HLA class I transplantation antigens.
Borenstein SH, Graham J, Zhang XL, Chamberlain JW
J Immunol. 2000
PubMed ID: 10946256
Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera.
Wang CC, Biben C, Robb L, Nassir F, Barnett L, Davidson NO, Koentgen F, Tarlinton D, Harvey RP
Dev Biol. 2000
PubMed ID: 10926756
Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection.
Mañes S, del Real G, Lacalle RA, Lucas P, Gómez-Moutón C, Sánchez-Palomino S, Delgado R, Alcamí J, Mira E, Martínez-A C
EMBO Rep. 2000
PubMed ID: 11265761
Energetics of the HIV gp120-CD4 binding reaction.
Myszka DG, Sweet RW, Hensley P, Brigham-Burke M, Kwong PD, Hendrickson WA, Wyatt R, Sodroski J, Doyle ML
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922058
V2 loop glycosylation of the human immunodeficiency virus type 1 SF162 envelope facilitates interaction of this protein with CD4 and CCR5 receptors and protects the virus from neutralization by anti-V3 loop and anti-CD4 binding site antibodies.
Ly A, Stamatatos L
J Virol. 2000
PubMed ID: 10888615
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.
Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M
Cell. 2000
PubMed ID: 10943842
Prolonged allograft survival in anti-CD4 antibody transgenic mice: lack of residual helper T cells compared with other CD4-deficient mice.
Han WR, Zhan Y, Murray-Segal LJ, Brady JL, Lew AM, Mottram PL
Transplantation. 2000
PubMed ID: 10919596
Coreceptor function of mutant human CD4 molecules without affinity to gp120 of human immunodeficiency virus.
Tachibana M, Siddiqi MA, Ikegami Y, Eshima K, Shirota-Someya Y, Tahara-Hanaoka S, Koito A, Iizuka M, Shinohara N
J Biol Chem. 2000
PubMed ID: 10779509
The HIV-1 Env protein signal sequence retards its cleavage and down-regulates the glycoprotein folding.
Li Y, Luo L, Thomas DY, Kang CY
Virology. 2000
PubMed ID: 10873786
Impaired delayed-type hypersensitivity response in mutant mice secreting soluble CD4 without expression of membrane-bound CD4.
Wang CR, Hino A, Yoshimoto T, Nagase H, Kato T, Hirokawa K, Matsuzawa A, Nariuchi H
Immunology. 2000
PubMed ID: 10929052
Evidence for a unique expression of CD4 on murine vaginal CD4+ cells.
Wormley FL, Scott M, Luo W, Baker M, Chaiban J, Fidel PL
Immunology. 2000
PubMed ID: 10929051
Requirement for RORgamma in thymocyte survival and lymphoid organ development.
Sun Z, Unutmaz D, Zou YR, Sunshine MJ, Pierani A, Brenner-Morton S, Mebius RE, Littman DR
Science. 2000
PubMed ID: 10875923
Critical role of enhanced CD4 affinity in laboratory adaptation of human immunodeficiency virus type 1.
Platt EJ, Kozak SL, Kabat D
AIDS Res Hum Retroviruses. 2000
PubMed ID: 10875613
Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells.
Xiao X, Kinter A, Broder CC, Dimitrov DS
Exp Mol Pathol. 2000
PubMed ID: 10816381
Induction of CD4(+) T-cell-independent immunoglobulin responses by inactivated influenza virus.
Sha Z, Compans RW
J Virol. 2000
PubMed ID: 10799573
Mapping the CD4 binding domain of gp17, a glycoprotein secreted from seminal vesicles and breast carcinomas.
Basmaciogullari S, Autiero M, Culerrier R, Mani JC, Gaubin M, Mishal Z, Guardiola J, Granier C, Piatier-Tonneau D
Biochemistry. 2000
PubMed ID: 10820003
Induction of acute pleural inflammation by Staphylococcus aureus. I. CD4+ T cells play a critical role in experimental empyema.
Mohammed KA, Nasreen N, Ward MJ, Antony VB
J Infect Dis. 2000
PubMed ID: 10823770
HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation.
Liu QH, Williams DA, McManus C, Baribaud F, Doms RW, Schols D, De Clercq E, Kotlikoff MI, Collman RG, Freedman BD
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10758170
The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease.
Liu P, Aitken K, Kong YY, Opavsky MA, Martino T, Dawood F, Wen WH, Kozieradzki I, Bachmaier K, Straus D, Mak TW, Penninger JM
Nat Med. 2000
PubMed ID: 10742150
Altered aging-related thymic involution in T cell receptor transgenic, MHC-deficient, and CD4-deficient mice.
Lau LL, Spain LM
Mech Ageing Dev. 2000
PubMed ID: 10799708
Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice.
Kennedy MK, Glaccum M, Brown SN, Butz EA, Viney JL, Embers M, Matsuki N, Charrier K, Sedger L, Willis CR, Brasel K, Morrissey PJ, Stocking K, Schuh JC, Joyce S, Peschon JJ
J Exp Med. 2000
PubMed ID: 10704459
Role of glycosphingolipid microdomains in CD4-dependent HIV-1 fusion.
Fantini J, Hammache D, Piéroni G, Yahi N
Glycoconj J. 2000
PubMed ID: 11201791
Beta 2-microglobulin/CD8 -/- mice reveal significant role for CD8+ T cells in graft rejection responses in beta 2-microglobulin -/- mice.
Freland S, Ljunggren HG
Scand J Immunol. 2000
PubMed ID: 10736089
Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation.
Akari H, Arold S, Fukumori T, Okazaki T, Strebel K, Adachi A
J Virol. 2000
PubMed ID: 10684310
Modulation of CD4, CXCR-4, and CCR-5 makes human hematopoietic progenitor cell lines infected with human herpesvirus-6 susceptible to human immunodeficiency virus type 1.
Vignoli M, Furlini G, Re MC, Ramazzotti E, La Placa M
J Hematother Stem Cell Res. 2000
PubMed ID: 10738970
Involvement of both the V2 and V3 regions of the CCR5-tropic human immunodeficiency virus type 1 envelope in reduced sensitivity to macrophage inflammatory protein 1alpha.
Maeda Y, Foda M, Matsushita S, Harada S
J Virol. 2000
PubMed ID: 10644351
Oxidation of aglycone of glycosphingolipids: serine and ceramide acid precursors for soluble glycoconjugates.
Mylvaganam M, Lingwood CA
Methods Enzymol. 2000
PubMed ID: 11070895
Differential level in co-down-modulation of CD4 and CXCR4 primed by HIV-1 gp120 in response to phorbol ester, PMA, among HIV-1 isolates.
Tahara-Hanaoka S, Ushijima Y, Tarui H, Wada M, Hara T, Imanishi S, Yamaguchi T, Hattori T, Nakauchi H, Koito A
Microbiol Immunol. 2000
PubMed ID: 10941932
HIV-1 gp41: role in HIV entry and prevention.
Chen YH, Xiao Y, Dierich MP
Immunobiology. 2000
PubMed ID: 10776787
A human milk factor susceptible to cathepsin D inhibitors enhances human immunodeficiency virus type 1 infectivity and allows virus entry into a mammary epithelial cell line.
El Messaoudi K, Thiry LF, Liesnard C, Van Tieghem N, Bollen A, Moguilevsky N
J Virol. 2000
PubMed ID: 10623764
Determinants of syncytium formation in microglia by human immunodeficiency virus type 1: role of the V1/V2 domains.
Shieh JT, Martín J, Baltuch G, Malim MH, González-Scarano F
J Virol. 2000
PubMed ID: 10623731
Sequential CD4-coreceptor interactions in human immunodeficiency virus type 1 Env function: soluble CD4 activates Env for coreceptor-dependent fusion and reveals blocking activities of antibodies against cryptic conserved epitopes on gp120.
Salzwedel K, Smith ED, Dey B, Berger EA
J Virol. 2000
PubMed ID: 10590121
Glycans and proteoglycans are involved in the interactions of human immunodeficiency virus type 1 envelope glycoprotein and of SDF-1alpha with membrane ligands of CD4(+) CXCR4(+) cells.
Mbemba E, Benjouad A, Saffar L, Gattegno L
Virology. 1999
PubMed ID: 10600606
Negative regulation of CD4 lineage development and responses by CD5.
Peña-Rossi C, Zuckerman LA, Strong J, Kwan J, Ferris W, Chan S, Tarakhovsky A, Beyers AD, Killeen N
J Immunol. 1999
PubMed ID: 10586041
New reporter cell lines to study macrophage-tropic HIV envelope protein-mediated cell-cell fusion.
Hong YL, Wu LH, Cui M, McMaster G, Hunt SW, Chung FZ
AIDS Res Hum Retroviruses. 1999
PubMed ID: 10606089
Effects of the human CD38 glycoprotein on the early stages of the HIV-1 replication cycle.
Savarino A, Bottarel F, Calosso L, Feito MJ, Bensi T, Bragardo M, Rojo JM, Pugliese A, Abbate I, Capobianchi MR, Dianzani F, Malavasi F, Dianzani U
FASEB J. 1999
PubMed ID: 10593874
Glial and neuronal cells express functional chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor 1.
Bajetto A, Bonavia R, Barbero S, Piccioli P, Costa A, Florio T, Schettini G
J Neurochem. 1999
PubMed ID: 10582593
Host cyclophilin A mediates HIV-1 attachment to target cells via heparans.
Saphire AC, Bobardt MD, Gallay PA
EMBO J. 1999
PubMed ID: 10581250
Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity.
LaBranche CC, Hoffman TL, Romano J, Haggarty BS, Edwards TG, Matthews TJ, Doms RW, Hoxie JA
J Virol. 1999
PubMed ID: 10559349
Cell surface CD4 inhibits HIV-1 particle release by interfering with Vpu activity.
Bour S, Perrin C, Strebel K
J Biol Chem. 1999
PubMed ID: 10559275
Binding of soluble recombinant HIV envelope glycoprotein, rgp120, induces conformational changes in the cellular membrane-anchored CD4 molecule.
Yachou A, Sékaly RP
Biochem Biophys Res Commun. 1999
PubMed ID: 10558884
Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction.
Bosselut R, Zhang W, Ashe JM, Kopacz JL, Samelson LE, Singer A
J Exp Med. 1999
PubMed ID: 10562325
Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein.
Vita C, Drakopoulou E, Vizzavona J, Rochette S, Martin L, Ménez A, Roumestand C, Yang YS, Ylisastigui L, Benjouad A, Gluckman JC
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10557278
Coreceptor usage and RANTES sensitivity of non-syncytium-inducing HIV-1 isolates obtained from patients with AIDS.
Jansson M, Backström E, Björndal A, Holmberg V, Rossi P, Fenyö EM, Popovic M, Albert J, Wigzell H
J Hum Virol. 1999
PubMed ID: 10774549
The effect on immunoglobulin glycosylation of altering in vivo production of immunoglobulin G.
Jeddi P, Keusch J, Lydyard PM, Bodman-Smith KB, Chesnutt MS, Wofsy D, Hirota H, Taga T, Delves PJ
Immunology. 1999
PubMed ID: 10583610
A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages.
Matsumoto M, Tanaka T, Kaisho T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Akira S
J Immunol. 1999
PubMed ID: 10528209
Negative regulation of CD4 expression in T cells by the transcriptional repressor ZEB.
Brabletz T, Jung A, Hlubek F, Löhberg C, Meiler J, Suchy U, Kirchner T
Int Immunol. 1999
PubMed ID: 10508188
Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1.
Pace KE, Lee C, Stewart PL, Baum LG
J Immunol. 1999
PubMed ID: 10490978
Lymphotropic virions affect chemokine receptor-mediated neural signaling and apoptosis: implications for human immunodeficiency virus type 1-associated dementia.
Zheng J, Ghorpade A, Niemann D, Cotter RL, Thylin MR, Epstein L, Swartz JM, Shepard RB, Liu X, Nukuna A, Gendelman HE
J Virol. 1999
PubMed ID: 10482576
The cell death-inducing ability of glycoprotein 120 from different HIV strains correlates with their ability to induce CD4 lateral association with CD95 on CD4+ T cells.
Bottarel F, Feito MJ, Bragardo M, Bonissoni S, Buonfiglio D, DeFranco S, Malavasi F, Bensi T, Ramenghi U, Dianzani U
AIDS Res Hum Retroviruses. 1999
PubMed ID: 10505674
Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection.
Opavsky MA, Penninger J, Aitken K, Wen WH, Dawood F, Mak T, Liu P
Circ Res. 1999
PubMed ID: 10488058
Requirement for CD4+ T cells in V beta 4+CD8+ T cell activation associated with latent murine gammaherpesvirus infection.
Flaño E, Woodland DL, Blackman MA
J Immunol. 1999
PubMed ID: 10477611
Differential control of autoantibodies and lymphoproliferation by Fas ligand expression on CD4+ and CD8+ T cells in vivo.
Maldonado MA, MacDonald GC, Kakkanaiah VN, Fecho K, Dransfield M, Sekiguchi D, Cohen PL, Eisenberg RA
J Immunol. 1999
PubMed ID: 10477580
Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells.
Newell KA, He G, Guo Z, Kim O, Szot GL, Rulifson I, Zhou P, Hart J, Thistlethwaite JR, Bluestone JA
J Immunol. 1999
PubMed ID: 10452966
Effects of the exogenous Nef protein on HIV-1 target cells.
Pugliese A, Cantamessa C, Saini A, Piragino A, Gennero L, Martini C, Torre D
Cell Biochem Funct. 1999
PubMed ID: 10451539
VIP and D-ala-peptide T-amide release chemokines which prevent HIV-1 GP120-induced neuronal death.
Brenneman DE, Hauser J, Spong CY, Phillips TM, Pert CB, Ruff M
Brain Res. 1999
PubMed ID: 10446313
Roles of CD4 and coreceptors in binding, endocytosis, and proteolysis of gp120 envelope glycoproteins derived from human immunodeficiency virus type 1.
Kozak SL, Kuhmann SE, Platt EJ, Kabat D
J Biol Chem. 1999
PubMed ID: 10438529
Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia.
Zheng J, Thylin MR, Ghorpade A, Xiong H, Persidsky Y, Cotter R, Niemann D, Che M, Zeng YC, Gelbard HA, Shepard RB, Swartz JM, Gendelman HE
J Neuroimmunol. 1999
PubMed ID: 10430052
Role of glycosphingolipids in HIV-1 entry: requirement of globotriosylceramide (Gb3) in CD4/CXCR4-dependent fusion.
Puri A, Hug P, Jernigan K, Rose P, Blumenthal R
Biosci Rep. 1999
PubMed ID: 10589997
Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic.
Zhang W, Canziani G, Plugariu C, Wyatt R, Sodroski J, Sweet R, Kwong P, Hendrickson W, Chaiken I
Biochemistry. 1999
PubMed ID: 10413516
Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis.
Kaul M, Lipton SA
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10393974
A mechanism of resistance to HIV-1 entry: inefficient interactions of CXCR4 with CD4 and gp120 in macrophages.
Dimitrov DS, Norwood D, Stantchev TS, Feng Y, Xiao X, Broder CC
Virology. 1999
PubMed ID: 10364484
Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner.
Lama J, Mangasarian A, Trono D
Curr Biol. 1999
PubMed ID: 10375528
Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein.
Ross TM, Oran AE, Cullen BR
Curr Biol. 1999
PubMed ID: 10375525
Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4+ T cells.
Su SB, Gong W, Grimm M, Utsunomiya I, Sargeant R, Oppenheim JJ, Ming Wang J
J Immunol. 1999
PubMed ID: 10358157
Human erythrocyte glycosphingolipids as alternative cofactors for human immunodeficiency virus type 1 (HIV-1) entry: evidence for CD4-induced interactions between HIV-1 gp120 and reconstituted membrane microdomains of glycosphingolipids (Gb3 and GM3).
Hammache D, Yahi N, Maresca M, Piéroni G, Fantini J
J Virol. 1999
PubMed ID: 10233996
The implication of the chemokine receptor CXCR4 in HIV-1 envelope protein-induced apoptosis is independent of the G protein-mediated signalling.
Blanco J, Jacotot E, Cabrera C, Cardona A, Clotet B, De Clercq E, Esté JA
AIDS. 1999
PubMed ID: 10371171
CD8+ CTLs are essential for protective immunity against Encephalitozoon cuniculi infection.
Khan IA, Schwartzman JD, Kasper LH, Moretto M
J Immunol. 1999
PubMed ID: 10229850
Mechanisms of nasal tolerance induction in experimental autoimmune myasthenia gravis: identification of regulatory cells.
Shi FD, Li H, Wang H, Bai X, van der Meide PH, Link H, Ljunggren HG
J Immunol. 1999
PubMed ID: 10229808
Identification of determinants of interaction between CXCR4 and gp120 of a dual-tropic HIV-1DH12 isolate.
Lee MK, Heaton J, Cho MW
Virology. 1999
PubMed ID: 10329539
Corynebacterium parvum- and Mycobacterium bovis Bacillus Calmette and Guerin-induced granuloma formation in mice lacking CD4 and CD8.
Senaldi G, Shaklee CL, Mak TW, Ulich TR
Cell Immunol. 1999
PubMed ID: 10222057
HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.
Kim YH, Chang SH, Kwon JH, Rhee SS
Virology. 1999
PubMed ID: 10208934
Generation and function of bone marrow-derived dendritic cells from CD4/CD8(-/-) double-knockout mice.
Corsi MM, Sandberg JK, Wasserman K, Maes HH, Kiessling R
Immunol Lett. 1999
PubMed ID: 10369133
Generation of humanized mice susceptible to peptide-induced inflammatory heart disease.
Bachmaier K, Neu N, Yeung RS, Mak TW, Liu P, Penninger JM
Circulation. 1999
PubMed ID: 10199887
Apoptosis induced by crosslinking of CD4 on activated human B cells.
Cutrona G, Leanza N, Ulivi M, Majolini MB, Taborelli G, Zupo S, Baldari CT, Roncella S, Ferrarini M
Cell Immunol. 1999
PubMed ID: 10202115
Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes.
Piguet V, Gu F, Foti M, Demaurex N, Gruenberg J, Carpentier JL, Trono D
Cell. 1999
PubMed ID: 10199403
A novel mouse model of HIV-1 disease.
Jolicoeur P, Kay DG, Cool M, Jothy S, Rebai N, Hanna Z
Leukemia. 1999
PubMed ID: 10232371
Identification of CXCR4 domains that support coreceptor and chemokine receptor functions.
Doranz BJ, Orsini MJ, Turner JD, Hoffman TL, Berson JF, Hoxie JA, Peiper SC, Brass LF, Doms RW
J Virol. 1999
PubMed ID: 10074122
Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry.
Farzan M, Mirzabekov T, Kolchinsky P, Wyatt R, Cayabyab M, Gerard NP, Gerard C, Sodroski J, Choe H
Cell. 1999
PubMed ID: 10089882
Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice.
McIndoe RA, Bohlman B, Chi E, Schuster E, Lindhardt M, Hood L
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10051620
Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts.
Nakatsuji T
Tohoku J Exp Med. 1999
PubMed ID: 10458478
A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice.
Kassiotis G, Bauer J, Akassoglou K, Lassmann H, Kollias G, Probert L
Eur J Immunol. 1999
PubMed ID: 10092095
Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice.
Rottenberg ME, Gigliotti Rothfuchs AC, Gigliotti D, Svanholm C, Bandholtz L, Wigzell H
J Immunol. 1999
PubMed ID: 10072530
Timing and casting for actors of thymic negative selection.
Dautigny N, Le Campion A, Lucas B
J Immunol. 1999
PubMed ID: 9973382
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells.
Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Deursen J, Sangster MY, Bunting KD, Grosveld GC, Ihle JN
Immunity. 1999
PubMed ID: 10072077
HIV-1 gp160 decreases the K+ voltage-gated current from Jurkat E6.1 T cells by up-phosphorylation.
Dellis O, Bouteau F, Guenounou M, Rona JP
FEBS Lett. 1999
PubMed ID: 9989602
Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression.
Fukushi M, Dixon J, Kimura T, Tsurutani N, Dixon MJ, Yamamoto N
FEBS Lett. 1999
PubMed ID: 9923610
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Altered thymic positive selection and intracellular signals in Cbl-deficient mice.
Naramura M, Kole HK, Hu RJ, Gu H
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9861006
The central role of CD4(+) T cells in the antitumor immune response.
Hung K, Hayashi R, Lafond-Walker A, Lowenstein C, Pardoll D, Levitsky H
J Exp Med. 1998
PubMed ID: 9858522
Visualization of CD4/CD8 T cell commitment.
Chan S, Correia-Neves M, Dierich A, Benoist C, Mathis D
J Exp Med. 1998
PubMed ID: 9858518
Interaction of human immunodeficiency virus type 1 envelope glycoprotein V3 loop with CCR5 and CD4 at the membrane of human primary macrophages.
Rabehi L, Seddiki N, Benjouad A, Gluckman JC, Gattegno L
AIDS Res Hum Retroviruses. 1998
PubMed ID: 9870313
Structural basis of the gp120 superantigen-binding site on human immunoglobulins.
Karray S, Juompan L, Maroun RC, Isenberg D, Silverman GJ, Zouali M
J Immunol. 1998
PubMed ID: 9862697
Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1.
Mulder GB, Manley N, Maggio-Price L
Teratology. 1998
PubMed ID: 9894676
Mice lacking the transcription factor CIITA--a second look.
Williams GS, Malin M, Vremec D, Chang CH, Boyd R, Benoist C, Mathis D
Int Immunol. 1998
PubMed ID: 9885917
Glycolipids as potential binding sites for HIV: topology in the sperm plasma membrane in relation to the regulation of membrane fusion.
Gadella BM, Hammache D, Piéroni G, Colenbrander B, van Golde LM, Fantini J
J Reprod Immunol. 1998
PubMed ID: 10213313
New insights into the interaction between the gp120 and the HIV receptor in human sperm (human.sperm/gp120/galactoglycerolipid/antigalactosylceramide/seminolip id/spermatogonia).
Brogi A, Presentini R, Moretti E, Strazza M, Piomboni P, Costantino-Ceccarini E
J Reprod Immunol. 1998
PubMed ID: 10213312
A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4.
Greenberg M, DeTulleo L, Rapoport I, Skowronski J, Kirchhausen T
Curr Biol. 1998
PubMed ID: 9811611
A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor.
Bresnahan PA, Yonemoto W, Ferrell S, Williams-Herman D, Geleziunas R, Greene WC
Curr Biol. 1998
PubMed ID: 9811606
BID, a proapoptotic BCL-2 family member, is localized to mouse chromosome 6 and human chromosome 22q11.
Wang K, Yin XM, Copeland NG, Gilbert DJ, Jenkins NA, Keck CL, Zimonjic DB, Popescu NC, Korsmeyer SJ
Genomics. 1998
PubMed ID: 9790773
HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation.
Wang JM, Ueda H, Howard OM, Grimm MC, Chertov O, Gong X, Gong W, Resau JH, Broder CC, Evans G, Arthur LO, Ruscetti FW, Oppenheim JJ
J Immunol. 1998
PubMed ID: 9780207
Normal thymic selection of TCR transgenic CD4 T cells, but impaired survival in the periphery despite the presence of selecting MHC molecules.
Barthlott T, Wright RJ, Stockinger B
J Immunol. 1998
PubMed ID: 9780168
CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4(+) T cells.
Berndt C, Möpps B, Angermüller S, Gierschik P, Krammer PH
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9770524
Differential antibody reactivity and CD4 binding of the mammary tumor marker protein GCDFP-15 from breast cyst and its counterparts from exocrine epithelia.
Caputo E, Autiero M, Mani JC, Basmociogullari S, Piatier-Tonneau D, Guardiola J
Int J Cancer. 1998
PubMed ID: 9724097
Thymic heterotypic cellular complexes in gene-targeted mice with defined blocks in T cell development and adhesion molecule expression.
Oliveira-dos-Santos AJ, Penninger JM, Rieker-Geley T, Matsumoto G, Mak TM, Wick G
Eur J Immunol. 1998
PubMed ID: 9754575
Interactions among HIV gp120, CD4, and CXCR4: dependence on CD4 expression level, gp120 viral origin, conservation of the gp120 COOH- and NH2-termini and V1/V2 and V3 loops, and sensitivity to neutralizing antibodies.
Mondor I, Moulard M, Ugolini S, Klasse PJ, Hoxie J, Amara A, Delaunay T, Wyatt R, Sodroski J, Sattentau QJ
Virology. 1998
PubMed ID: 9721247
CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis.
Murray PD, Pavelko KD, Leibowitz J, Lin X, Rodriguez M
J Virol. 1998
PubMed ID: 9696828
Dissociation of the CD4 and CXCR4 binding properties of human immunodeficiency virus type 1 gp120 by deletion of the first putative alpha-helical conserved structure.
Missé D, Cerutti M, Schmidt I, Jansen A, Devauchelle G, Jansen F, Veas F
J Virol. 1998
PubMed ID: 9696823
HIV gp120: double lock strategy foils host defences.
Sattentau QJ
Structure. 1998
PubMed ID: 9739096
CD4 regulation of TCR signaling and T cell differentiation following stimulation with peptides of different affinities for the TCR.
Leitenberg D, Boutin Y, Constant S, Bottomly K
J Immunol. 1998
PubMed ID: 9686579
Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway.
Popik W, Hesselgesser JE, Pitha PM
J Virol. 1998
PubMed ID: 9658081
Determinants of human immunodeficiency virus type 1 envelope glycoprotein activation by soluble CD4 and monoclonal antibodies.
Sullivan N, Sun Y, Binley J, Lee J, Barbas CF, Parren PW, Burton DR, Sodroski J
J Virol. 1998
PubMed ID: 9658072
A Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck.
Huse M, Eck MJ, Harrison SC
J Biol Chem. 1998
PubMed ID: 9668045
Cloning of a novel C-type lectin expressed by murine macrophages.
Balch SG, McKnight AJ, Seldin MF, Gordon S
J Biol Chem. 1998
PubMed ID: 9660840
CD4+ T cells migrate into inflamed skin only if they express ligands for E- and P-selectin.
Tietz W, Allemand Y, Borges E, von Laer D, Hallmann R, Vestweber D, Hamann A
J Immunol. 1998
PubMed ID: 9670976
The protein tyrosine kinase p56lck is required for triggering NF-kappaB activation upon interaction of human immunodeficiency virus type 1 envelope glycoprotein gp120 with cell surface CD4.
Briant L, Robert-Hebmann V, Acquaviva C, Pelchen-Matthews A, Marsh M, Devaux C
J Virol. 1998
PubMed ID: 9621091
Spontaneous and ligand-induced trafficking of CXC-chemokine receptor 4.
Tarasova NI, Stauber RH, Michejda CJ
J Biol Chem. 1998
PubMed ID: 9632631
A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding.
Rizzuto CD, Wyatt R, Hernández-Ramos N, Sun Y, Kwong PD, Hendrickson WA, Sodroski J
Science. 1998
PubMed ID: 9632396
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.
Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA
Nature. 1998
PubMed ID: 9641677
Cutting edge: JAK3 activation and rescue of T cells from HIV gp120-induced unresponsiveness.
Selliah N, Finkel TH
J Immunol. 1998
PubMed ID: 9637477
CXCR4 sequences involved in coreceptor determination of human immunodeficiency virus type-1 tropism. Unmasking of activity with M-tropic Env glycoproteins.
Wang ZX, Berson JF, Zhang TY, Cen YH, Sun Y, Sharron M, Lu ZH, Peiper SC
J Biol Chem. 1998
PubMed ID: 9614108
Solution structure of the cytoplasmic domain of the human CD4 glycoprotein by CD and 1H NMR spectroscopy: implications for biological functions.
Wray V, Mertins D, Kiess M, Henklein P, Trowitzsch-Kienast W, Schubert U
Biochemistry. 1998
PubMed ID: 9622505
Structural interactions between chemokine receptors, gp120 Env and CD4.
Choe H, Martin KA, Farzan M, Sodroski J, Gerard NP, Gerard C
Semin Immunol. 1998
PubMed ID: 9653051
Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity.
Lin X, Pease LR, Murray PD, Rodriguez M
J Immunol. 1998
PubMed ID: 9605173
CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralization.
Sullivan N, Sun Y, Sattentau Q, Thali M, Wu D, Denisova G, Gershoni J, Robinson J, Moore J, Sodroski J
J Virol. 1998
PubMed ID: 9573233
CCR5 coreceptor utilization involves a highly conserved arginine residue of HIV type 1 gp120.
Wang WK, Dudek T, Zhao YJ, Brumblay HG, Essex M, Lee TH
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9576954
Sequential interaction of CD4 and HIV-1 gp120 with a reconstituted membrane patch of ganglioside GM3: implications for the role of glycolipids as potential HIV-1 fusion cofactors.
Hammache D, Yahi N, Piéroni G, Ariasi F, Tamalet C, Fantini J
Biochem Biophys Res Commun. 1998
PubMed ID: 9600078
Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is mediated by the chemokine receptor CXCR4.
Hesselgesser J, Taub D, Baskar P, Greenberg M, Hoxie J, Kolson DL, Horuk R
Curr Biol. 1998
PubMed ID: 9601645
Importance of the N-glycan in the V3 loop of HIV-1 envelope protein for CXCR-4- but not CCR-5-dependent fusion.
Nakayama EE, Shioda T, Tatsumi M, Xin X, Yu D, Ohgimoto S, Kato A, Sakai Y, Ohnishi Y, Nagai Y
FEBS Lett. 1998
PubMed ID: 9600268
Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry.
Rubbert A, Combadiere C, Ostrowski M, Arthos J, Dybul M, Machado E, Cohn MA, Hoxie JA, Murphy PM, Fauci AS, Weissman D
J Immunol. 1998
PubMed ID: 9558100
Disruption of the CD4-major histocompatibility complex class II interaction blocks the development of CD4(+) T cells in vivo.
Riberdy JM, Mostaghel E, Doyle C
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9539765
Specific interaction of HIV-1 and HIV-2 surface envelope glycoproteins with monolayers of galactosylceramide and ganglioside GM3.
Hammache D, Piéroni G, Yahi N, Delézay O, Koch N, Lafont H, Tamalet C, Fantini J
J Biol Chem. 1998
PubMed ID: 9525894
Requirement of the CD8+ or CD4+ T lymphocyte subsets for the rejection of lymphoma and fibrosarcoma grafts studied in gene knockout hosts.
Wen T, Trümper L, Fung-Leung W, Rahemtulla A, Klein E, Klein G, Mak TW
Immunol Lett. 1998
PubMed ID: 9657273
Enhanced lymphoproliferation and diminished autoimmunity in CD4-deficient MRL/lpr mice.
Chesnutt MS, Finck BK, Killeen N, Connolly MK, Goodman H, Wofsy D
Clin Immunol Immunopathol. 1998
PubMed ID: 9576007
Novel role of human CD4 molecule identified in neurodegeneration.
Buttini M, Westland CE, Masliah E, Yafeh AM, Wyss-Coray T, Mucke L
Nat Med. 1998
PubMed ID: 9546790
Alanine substitutions of polar and nonpolar residues in the amino-terminal domain of CCR5 differently impair entry of macrophage- and dualtropic isolates of human immunodeficiency virus type 1.
Rabut GE, Konner JA, Kajumo F, Moore JP, Dragic T
J Virol. 1998
PubMed ID: 9525683
A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif.
Margottin F, Bour SP, Durand H, Selig L, Benichou S, Richard V, Thomas D, Strebel K, Benarous R
Mol Cell. 1998
PubMed ID: 9660940
Identification of determinants on a dualtropic human immunodeficiency virus type 1 envelope glycoprotein that confer usage of CXCR4.
Cho MW, Lee MK, Carney MC, Berson JF, Doms RW, Martin MA
J Virol. 1998
PubMed ID: 9499115
Human immunodeficiency virus (HIV) envelope binds to CXCR4 independently of CD4, and binding can be enhanced by interaction with soluble CD4 or by HIV envelope deglycosylation.
Bandres JC, Wang QF, O'Leary J, Baleaux F, Amara A, Hoxie JA, Zolla-Pazner S, Gorny MK
J Virol. 1998
PubMed ID: 9499113
CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway.
Schubert U, Antón LC, Bacík I, Cox JH, Bour S, Bennink JR, Orlowski M, Strebel K, Yewdell JW
J Virol. 1998
PubMed ID: 9499087
Novel mutant mice secreting soluble CD4 without expression of membrane-bound CD4.
Nagase H, Wang CR, Yoshimoto T, Sugishita C, Shiroishi T, Matsuzawa A, Nariuchi H
Eur J Immunol. 1998
PubMed ID: 9521047
T cells chronically infected with HIV do not contain sufficient Nef to promote CD4 downmodulation in the absence of envelope-mediated effects.
Cucchiarini M, Barcellini-Couget S, Lefebvre JC, Doglio A
J Acquir Immune Defic Syndr Hum Retrovirol. 1998
PubMed ID: 9473011
Heparin and its derivatives bind to HIV-1 recombinant envelope glycoproteins, rather than to recombinant HIV-1 receptor, CD4.
Harrop HA, Rider CC
Glycobiology. 1998
PubMed ID: 9451022
A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5.
Farzan M, Choe H, Vaca L, Martin K, Sun Y, Desjardins E, Ruffing N, Wu L, Wyatt R, Gerard N, Gerard C, Sodroski J
J Virol. 1998
PubMed ID: 9445013
The level of CD4 surface protein influences T cell selection in the thymus.
Frank GD, Parnes JR
J Immunol. 1998
PubMed ID: 9551897
Conformational changes in cell surface HIV-1 envelope glycoproteins are triggered by cooperation between cell surface CD4 and co-receptors.
Jones PL, Korte T, Blumenthal R
J Biol Chem. 1998
PubMed ID: 9417096
The V3 region of gp120 is responsible for anti-HIV-1 activity of heparin sulphate.
Jagodzinski PP, Trzeciak WH
Acta Biochim Pol. 1998
PubMed ID: 9918507
Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6.
Ansari-Lari MA, Oeltjen JC, Schwartz S, Zhang Z, Muzny DM, Lu J, Gorrell JH, Chinault AC, Belmont JW, Miller W, Gibbs RA
Genome Res. 1998
PubMed ID: 9445485
Heparin-binding domain of human fibronectin binds HIV-1 gp120/160 and reduces virus infectivity.
Bozzini S, Falcone V, Conaldi PG, Visai L, Biancone L, Dolei A, Toniolo A, Speziale P
J Med Virol. 1998
PubMed ID: 9443108
Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry.
Dragic T, Trkola A, Lin SW, Nagashima KA, Kajumo F, Zhao L, Olson WC, Wu L, Mackay CR, Allaway GP, Sakmar TP, Moore JP, Maddon PJ
J Virol. 1998
PubMed ID: 9420225
Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization.
Puech A, Saint-Jore B, Funke B, Gilbert DJ, Sirotkin H, Copeland NG, Jenkins NA, Kucherlapati R, Morrow B, Skoultchi AI
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9405660
A crucial role for B cells in neuroinvasive scrapie.
Klein MA, Frigg R, Flechsig E, Raeber AJ, Kalinke U, Bluethmann H, Bootz F, Suter M, Zinkernagel RM, Aguzzi A
Nature. 1997
PubMed ID: 9414161
Apoptotic cell death upon contact of CD4+ T lymphocytes with HIV glycoprotein-expressing cells is mediated by caspases but bypasses CD95 (Fas/Apo-1) and TNF receptor 1.
Ohnimus H, Heinkelein M, Jassoy C
J Immunol. 1997
PubMed ID: 9548463
CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway.
Lesage S, Steff AM, Philippoussis F, Pagé M, Trop S, Mateo V, Hugo P
J Immunol. 1997
PubMed ID: 9366400
Inhibition of CD4 translation mediated by human immunodeficiency virus type 1 envelope protein in a cell-free system.
Bour S, Geleziunas R, Wainberg MA
J Biol Chem. 1997
PubMed ID: 9360974
Signals transduced through the CD4 molecule interfere with TCR/CD3-mediated ras activation leading to T cell anergy/apoptosis.
Tamma SM, Chirmule N, McCloskey TW, Oyaizu N, Kalyanaraman VS, Pahwa S
Clin Immunol Immunopathol. 1997
PubMed ID: 9344703
Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding.
Wu L, LaRosa G, Kassam N, Gordon CJ, Heath H, Ruffing N, Chen H, Humblias J, Samson M, Parmentier M, Moore JP, Mackay CR
J Exp Med. 1997
PubMed ID: 9334377
Syncytium formation induced by human immunodeficiency virus type 1 isolates correlates with affinity for CD4.
Watkins BA, Crowley R, Davis AE, Louie AT, Reitz MS
J Gen Virol. 1997
PubMed ID: 9349472
HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes.
Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, Nguyen HT, Yaba P, Delicat A, Georges AJ, Russo-Marie F
J Acquir Immune Defic Syndr Hum Retrovirol. 1997
PubMed ID: 9377118
Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor.
Hill CM, Deng H, Unutmaz D, Kewalramani VN, Bastiani L, Gorny MK, Zolla-Pazner S, Littman DR
J Virol. 1997
PubMed ID: 9261346
CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells.
Tamma SM, Chirmule N, Yagura H, Oyaizu N, Kalyanaraman V, Pahwa S
Blood. 1997
PubMed ID: 9269777
An investigation of the high-avidity antibody response to glycoprotein 120 of human immunodeficiency virus type 1.
Binley JM, Arshad H, Fouts TR, Moore JP
AIDS Res Hum Retroviruses. 1997
PubMed ID: 9264287
The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes.
Penninger JM, Sirard C, Mittrücker HW, Chidgey A, Kozieradzki I, Nghiem M, Hakem A, Kimura T, Timms E, Boyd R, Taniguchi T, Matsuyama T, Mak TW
Immunity. 1997
PubMed ID: 9285409
gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules.
Feito MJ, Bragardo M, Buonfiglio D, Bonissoni S, Bottarel F, Malavasi F, Dianzani U
Int Immunol. 1997
PubMed ID: 9263011
Modulation of Bcl-2 protein by CD4 cross-linking: a possible mechanism for lymphocyte apoptosis in human immunodeficiency virus infection and for rescue of apoptosis by interleukin-2.
Hashimoto F, Oyaizu N, Kalyanaraman VS, Pahwa S
Blood. 1997
PubMed ID: 9226175
RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein.
Mizuta R, LaSalle JM, Cheng HL, Shinohara A, Ogawa H, Copeland N, Jenkins NA, Lalande M, Alt FW
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9192668
STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1.
Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM
J Exp Med. 1997
PubMed ID: 9166430
A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development.
Wiest DL, Ashe JM, Howcroft TK, Lee HM, Kemper DM, Negishi I, Singer DS, Singer A, Abe R
Immunity. 1997
PubMed ID: 9208839
Putative alpha-helical structures in the human immunodeficiency virus type 1 Vpu protein and CD4 are involved in binding and degradation of the CD4 molecule.
Tiganos E, Yao XJ, Friborg J, Daniel N, Cohen EA
J Virol. 1997
PubMed ID: 9151836
Dimeric association and segmental variability in the structure of human CD4.
Wu H, Kwong PD, Hendrickson WA
Nature. 1997
PubMed ID: 9168119
Phosphorylation of both phosphoacceptor sites in the HIV-1 Vpu cytoplasmic domain is essential for Vpu-mediated ER degradation of CD4.
Paul M, Jabbar MA
Virology. 1997
PubMed ID: 9185604
Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4.
Hua J, Blair W, Truant R, Cullen BR
Virology. 1997
PubMed ID: 9168885
Impairment of T cell development in deltaEF1 mutant mice.
Higashi Y, Moribe H, Takagi T, Sekido R, Kawakami K, Kikutani H, Kondoh H
J Exp Med. 1997
PubMed ID: 9126927
CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4.
Mendiratta SK, Martin WD, Hong S, Boesteanu A, Joyce S, Van Kaer L
Immunity. 1997
PubMed ID: 9133426
Studies of the susceptibility of nude, CD4 knockout, and SCID mutant mice to the disease induced by the murine AIDS defective virus.
Simard C, Klein SJ, Mak T, Jolicoeur P
J Virol. 1997
PubMed ID: 9060661
Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.
Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA
Genome Res. 1997
PubMed ID: 9074930
Rapid degradation of CD4 in cells expressing human immunodeficiency virus type 1 Env and Vpu is blocked by proteasome inhibitors.
Fujita K, Omura S, Silver J
J Gen Virol. 1997
PubMed ID: 9049413
Sequestration of p56(lck) by gp120, a model for TCR desensitization.
Goldman F, Crabtree J, Hollenback C, Koretzky G
J Immunol. 1997
PubMed ID: 9036944
Identification of the B cell superantigen-binding site of HIV-1 gp120.
Karray S, Zouali M
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9037057
Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase.
Briand G, Barbeau B, Tremblay M
Virology. 1997
PubMed ID: 9123823
Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling.
Iafrate AJ, Bronson S, Skowronski J
EMBO J. 1997
PubMed ID: 9049297
Murine psoriasis-like disorder induced by naive CD4+ T cells.
Schön MP, Detmar M, Parker CM
Nat Med. 1997
PubMed ID: 9018237
A novel antibody-dependent cellular cytotoxicity epitope in gp120 is identified by two monoclonal antibodies isolated from a long-term survivor of human immunodeficiency virus type 1 infection.
Alsmadi O, Herz R, Murphy E, Pinter A, Tilley SA
J Virol. 1997
PubMed ID: 8995609
Differential susceptibility to HIV-GP120-sensitized apoptosis in CD4+ T-cell clones with different T-helper phenotypes: role of CD95/CD95L interactions.
Accornero P, Radrizzani M, Delia D, Gerosa F, Kurrle R, Colombo MP
Blood. 1997
PubMed ID: 9002959
Replacement of pre-T cell receptor signaling functions by the CD4 coreceptor.
Norment AM, Forbush KA, Nguyen N, Malissen M, Perlmutter RM
J Exp Med. 1997
PubMed ID: 8996248
Mapping of six germ-cell-specific genes to mouse chromosomes.
Matsui M, Ichihara H, Kobayashi S, Tanaka H, Tsuchida J, Nozaki M, Yoshimura Y, Nojima H, Rochelle JM, Nishimune Y, Taketo MM, Seldin MF
Mamm Genome. 1997
PubMed ID: 9337410
Ig VH-dependent interaction between immunoglobulins and CD4.
Lenert P, Lenert G, Zanetti M
Int Rev Immunol. 1997
PubMed ID: 9186786
The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane.
Mangasarian A, Foti M, Aiken C, Chin D, Carpentier JL, Trono D
Immunity. 1997
PubMed ID: 9052838
HIV glycoprotein gp120 inhibits TCR-CD3-mediated activation of fyn and lck.
Morio T, Chatila T, Geha RS
Int Immunol. 1997
PubMed ID: 9043947
Comparative analysis of the gp120-binding area of murine and human CD4 molecules.
Siddiqi MA, Tachibana M, Ohta S, Ikegami Y, Tahara-Hanaoka S, Huang YY, Shinohara N
J Acquir Immune Defic Syndr Hum Retrovirol. 1997
PubMed ID: 8989204
CD4 ligands inhibit the formation of multifunctional transduction complexes involved in T cell activation.
Jabado N, Pallier A, Le Deist F, Bernard F, Fischer A, Hivroz C
J Immunol. 1997
PubMed ID: 8977179
HIV-1 envelope glycoproteins-mediated apoptosis is regulated by CD4 dependent and independent mechanisms.
Jacotot E, Krust B, Callebaut C, Laurent-Crawford AG, Blanco J, Hovanessian AG
Apoptosis. 1997
PubMed ID: 14646564
Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding.
Wu H, Myszka DG, Tendian SW, Brouillette CG, Sweet RW, Chaiken IM, Hendrickson WA
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8986758
Two neutralizing anti-V3 monoclonal antibodies act by affecting different functions of human immunodeficiency virus type 1.
Armstrong SJ, McInerney TL, McLain L, Wahren B, Hinkula J, Levi M, Dimmock NJ
J Gen Virol. 1996
PubMed ID: 9000083
Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors.
Granelli-Piperno A, Moser B, Pope M, Chen D, Wei Y, Isdell F, O'Doherty U, Paxton W, Koup R, Mojsov S, Bhardwaj N, Clark-Lewis I, Baggiolini M, Steinman RM
J Exp Med. 1996
PubMed ID: 8976200
Receptor interference mediated by the envelope glycoproteins of various HIV-1 and HIV-2 isolates.
Martin RA, Nayak DP
Virus Res. 1996
PubMed ID: 8896248
Analysis of the interaction of an anti-HIV peptide, T22 ([Tyr5, 12, Lys7]-polyphemusin II), with gp120 and CD4 by surface plasmon resonance.
Tamamura H, Ishihara T, Otaka A, Murakami T, Ibuka T, Waki M, Matsumoto A, Yamamoto N, Fujii N
Biochim Biophys Acta. 1996
PubMed ID: 8948487
CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.
Trkola A, Dragic T, Arthos J, Binley JM, Olson WC, Allaway GP, Cheng-Mayer C, Robinson J, Maddon PJ, Moore JP
Nature. 1996
PubMed ID: 8906796
CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.
Wu L, Gerard NP, Wyatt R, Choe H, Parolin C, Ruffing N, Borsetti A, Cardoso AA, Desjardin E, Newman W, Gerard C, Sodroski J
Nature. 1996
PubMed ID: 8906795
The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection.
Cocchi F, DeVico AL, Garzino-Demo A, Cara A, Gallo RC, Lusso P
Nat Med. 1996
PubMed ID: 8898753
Postbinding events mediated by human immunodeficiency virus type 1 are sensitive to modifications in the D4-transmembrane linker region of CD4.
Moir S, Perreault J, Poulin L
J Virol. 1996
PubMed ID: 8892926
Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway.
Popik W, Pitha PM
Mol Cell Biol. 1996
PubMed ID: 8887682
Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines.
Lapham CK, Ouyang J, Chandrasekhar B, Nguyen NY, Dimitrov DS, Golding H
Science. 1996
PubMed ID: 8849450
IL-10 inhibits lipopolysaccharide-induced murine B cell proliferation and cross-linking of surface antigen receptors or ligation of CD40 restores the response.
Marcelletti JF
J Immunol. 1996
PubMed ID: 8871628
Molecular analysis of the cytoplasmic domain of CD4: overlapping but noncompetitive requirement for lck association and down-regulation by Nef.
Gratton S, Yao XJ, Venkatesan S, Cohen EA, Sékaly RP
J Immunol. 1996
PubMed ID: 8871625
Induction of lymphomonocyte activation by HIV-1 glycoprotein gp120. Possible role in AIDS pathogenesis.
Capobianchi MR
J Biol Regul Homeost Agents. 1996
PubMed ID: 9604776
Bimodal down-regulation of CD4 in cells expressing human immunodeficiency virus type 1 Vpu and Env.
Fujita K, Maldarelli F, Silver J
J Gen Virol. 1996
PubMed ID: 8887470
Development of T-cell lines expressing functional HIV-1 envelope glycoproteins for evaluation of immune responses in HIV-infected individuals.
Keler T, Li H, Cloyd MW, Vitale LA, Deo YM
J Acquir Immune Defic Syndr Hum Retrovirol. 1996
PubMed ID: 8862276
Characterization of CD4-gp120 activation intermediates during human immunodeficiency virus type 1 syncytium formation.
Hart TK, Truneh A, Bugelski PJ
AIDS Res Hum Retroviruses. 1996
PubMed ID: 8891109
Interaction between the cytoplasmic domains of HIV-1 Vpu and CD4: role of Vpu residues involved in CD4 interaction and in vitro CD4 degradation.
Margottin F, Benichou S, Durand H, Richard V, Liu LX, Gomas E, Benarous R
Virology. 1996
PubMed ID: 8806575
HIV envelope glycoprotein-induced cell killing by apoptosis is enhanced with increased expression of CD26 in CD4+ T cells.
Jacotot E, Callebaut C, Blanco J, Rivière Y, Krust B, Hovanessian AG
Virology. 1996
PubMed ID: 8806567
The natural history of disease expression in CD4 and CD8 gene-deleted New Zealand black (NZB) mice.
Chen SY, Takeoka Y, Ansari AA, Boyd R, Klinman DM, Gershwin ME
J Immunol. 1996
PubMed ID: 8805673
Cofactors provide the entry keys. HIV-1.
Wilkinson D
Curr Biol. 1996
PubMed ID: 8805353
CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef.
Chen BK, Gandhi RT, Baltimore D
J Virol. 1996
PubMed ID: 8709227
Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice.
Hazenbos WL, Gessner JE, Hofhuis FM, Kuipers H, Meyer D, Heijnen IA, Schmidt RE, Sandor M, Capel PJ, Daëron M, van de Winkel JG, Verbeek JS
Immunity. 1996
PubMed ID: 8769481
Both CD4+ and CD8+ T cells are essential to induce experimental autoimmune myasthenia gravis.
Zhang GX, Xiao BG, Bakhiet M, van der Meide P, Wigzell H, Link H, Olsson T
J Exp Med. 1996
PubMed ID: 8760788
Human antibodies that neutralize primary human immunodeficiency virus type 1 in vitro do not provide protection in an in vivo model.
Schutten M, Tenner-Racz K, Racz P, van Bekkum DW, Osterhaus AD
J Gen Virol. 1996
PubMed ID: 8760413
Polyoma tumor development in neonatally polyoma-virus-infected CD4-/- and CD8-/- single knockout and CD4-/-8-/- double knockout mice.
Berke Z, Wen T, Klein G, Dalianis T
Int J Cancer. 1996
PubMed ID: 8707416
A synthetic conformational epitope from the C4 domain of HIV Gp120 that binds CD4.
Robey FA, Harris-Kelson T, Robert-Guroff M, Batinić D, Ivanov B, Lewis MS, Roller PP
J Biol Chem. 1996
PubMed ID: 8663408
Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.
Bouvier G, Watrin F, Naspetti M, Verthuy C, Naquet P, Ferrier P
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8755570
Further insights on the inhibition of HIV type 1 infection in vitro by CD4-modified synthetic peptides containing phenylalanine.
Prieto I, Lasarte JJ, Sarobe P, Golvano J, Civeira MP, Gullón A, Prieto J, Borrás-Cuesta F
AIDS Res Hum Retroviruses. 1996
PubMed ID: 8827218
Altered CD4 interactions of HIV type 1 LAI variants selected for the capacity to induce membrane fusion in the presence of a monoclonal antibody to domain 2 of CD4.
Klasse PJ, Sattentau QJ
AIDS Res Hum Retroviruses. 1996
PubMed ID: 8827217
Guanine-rich oligonucleotide modified at the 5' terminal by dimethoxytrityl residue inhibits HIV-1 replication by specific interaction with the envelope glycoprotein.
Agatsuma T, Yamamoto I, Furukawa H, Nishigaki T
Antiviral Res. 1996
PubMed ID: 8811198
A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.
Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, Peiper SC, Parmentier M, Collman RG, Doms RW
Cell. 1996
PubMed ID: 8674120
The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.
Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J
Cell. 1996
PubMed ID: 8674119
Membrane anchorage of gp160 is necessary and sufficient to prevent CD4 transport to the cell surface.
Martin RA, Nayak DP
Virology. 1996
PubMed ID: 8661397
Mutational analysis of HIV-1 gp160-mediated receptor interference: intracellular complex formation.
Martin RA, Nayak DP
Virology. 1996
PubMed ID: 8661396
Generation of lymphocyte cell lines coexpressing CD4 and wild-type or mutant HIV type 1 glycoproteins: implications for HIV type 1 Env-induced cell lysis.
Krüger U, Pfeiffer T, Bosch V
AIDS Res Hum Retroviruses. 1996
PubMed ID: 8738430
Envelope glycoproteins of human immunodeficiency virus type 1: profound influences on immune functions.
Chirmule N, Pahwa S
Microbiol Rev. 1996
PubMed ID: 8801439
Activation-mediated CD4+ T cell unresponsiveness during acute Toxoplasma gondii infection in mice.
Khan IA, Matsuura T, Kasper LH
Int Immunol. 1996
PubMed ID: 8671678
The human immunodeficiency virus type 1 Vpu protein tethered to the CD4 extracellular domain is localized to the plasma membrane and is biologically active in the secretory pathway of mammalian cells: implications for the mechanisms of Vpu function.
Raja NU, Jabbar MA
Virology. 1996
PubMed ID: 8659106
Repression of human immunodeficiency virus type 1 long terminal repeat-driven gene expression by binding of the virus to its primary cellular receptor, the CD4 molecule.
Bérubé P, Barbeau B, Cantin R, Sékaly RP, Tremblay M
J Virol. 1996
PubMed ID: 8648738
HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor.
Feng Y, Broder CC, Kennedy PE, Berger EA
Science. 1996
PubMed ID: 8629022
Cell-free HIV-1Zr6 vif mutants are defective in binding to peripheral blood mononuclear cells and in internalization.
Nagashunmugam T, Friedman HM
DNA Cell Biol. 1996
PubMed ID: 8924209
HIV-1 envelope glycoprotein gp120 down-regulates CD4 expression in primary human macrophages through induction of endogenous tumour necrosis factor-alpha.
Karsten V, Gordon S, Kirn A, Herbein G
Immunology. 1996
PubMed ID: 8707350
LAG-3 is not responsible for selecting T helper cells in CD4-deficient mice.
Miyazaki T, Dierich A, Benoist C, Mathis D
Int Immunol. 1996
PubMed ID: 8671660
A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.
Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA
Genome Res. 1996
PubMed ID: 8723724
Rapid selection for an N-linked oligosaccharide by monoclonal antibodies directed against the V3 loop of human immunodeficiency virus type 1.
Schønning K, Jansson B, Olofsson S, Hansen JE
J Gen Virol. 1996
PubMed ID: 8627264
CD4 and CD8 expression and T cell antigen receptor gene rearrangement in early intrathymic precursor cells.
Ismaili J, Antica M, Wu L
Eur J Immunol. 1996
PubMed ID: 8625961
Covalently crosslinked complexes of human immunodeficiency virus type 1 (HIV-1) gp120 and CD4 receptor elicit a neutralizing immune response that includes antibodies selective for primary virus isolates.
Devico A, Silver A, Thronton AM, Sarngadharan MG, Pal R
Virology. 1996
PubMed ID: 8615032
Inhibition of HIV infection by pseudopeptides blocking viral envelope glycoprotein-mediated membrane fusion and cell death.
Callebaut C, Jacotot E, Guichard G, Krust B, Rey-Cuille M, Cointe D, Benkirane N, Blanco J, Muller S, Briand J, Hovanessian AG
Virology. 1996
PubMed ID: 8615021
Resistance to V3-directed neutralization caused by an N-linked oligosaccharide depends on the quaternary structure of the HIV-1 envelope oligomer.
Schønning K, Jansson B, Olofsson S, Nielsen JO, Hansen JS
Virology. 1996
PubMed ID: 8615015
The specificity and orientation of a TCR to its peptide-MHC class II ligands.
Sant'Angelo DB, Waterbury G, Preston-Hurlburt P, Yoon ST, Medzhitov R, Hong SC, Janeway CA
Immunity. 1996
PubMed ID: 8612131
MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.
Matechak EO, Killeen N, Hedrick SM, Fowlkes BJ
Immunity. 1996
PubMed ID: 8612128
Blind T-cell homeostasis in CD4-deficient mice.
Adleman LM, Wofsy D
J Acquir Immune Defic Syndr Hum Retrovirol. 1996
PubMed ID: 8601219
The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase.
Grzesiek S, Bax A, Clore GM, Gronenborn AM, Hu JS, Kaufman J, Palmer I, Stahl SJ, Wingfield PT
Nat Struct Biol. 1996
PubMed ID: 8599760
Soluble CD4 induces the binding of human immunodeficiency virus type 1 to cells via the V3 loop of glycoprotein 120 and specific sites in glycoprotein 41.
Demaria S, Bushkin Y
AIDS Res Hum Retroviruses. 1996
PubMed ID: 8906988
Studies of HIV-1 envelope glycoprotein-mediated fusion using a simple fluorescence assay.
Weiss CD, Barnett SW, Cacalano N, Killeen N, Littman DR, White JM
AIDS. 1996
PubMed ID: 8882662
Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein.
Moore JP, Sodroski J
J Virol. 1996
PubMed ID: 8627711
Nef-CD4 physical interaction sensed with the yeast two-hybrid system.
Rossi F, Gallina A, Milanesi G
Virology. 1996
PubMed ID: 8599229
Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation.
Aiken C, Krause L, Chen YL, Trono D
Virology. 1996
PubMed ID: 8599214
IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C.
Parada NA, Cruikshank WW, Danis HL, Ryan TC, Center DM
Cell Immunol. 1996
PubMed ID: 8599832
Interaction of an anti-HIV peptide, T22, with gp120 and CD4.
Tamamura H, Otaka A, Murakami T, Ishihara T, Ibuka T, Waki M, Matsumoto A, Yamamoto N, Fujii N
Biochem Biophys Res Commun. 1996
PubMed ID: 8605026
Evidence for distinct contributions of heavy and light chains to restriction of antibody recognition of the HIV-1 principal neutralization determinant.
Watkins BA, Davis AE, Fiorentini S, di Marzo Veronese F, Reitz MS
J Immunol. 1996
PubMed ID: 8568275
Design and synthesis of a highly immunogenic, discontinuous epitope of HIV-1 gp120 which binds to CD4+ve transfected cells.
Cotton GJ, Howie SE, Heslop I, Ross JA, Harrison DJ, Ramage R
Mol Immunol. 1996
PubMed ID: 8649438
Neutralizing antibodies to human immunodeficiency virus type-1 gp120 induce envelope glycoprotein subunit dissociation.
Poignard P, Fouts T, Naniche D, Moore JP, Sattentau QJ
J Exp Med. 1996
PubMed ID: 8627160
Nitric oxide and host defense against Pneumocystis carinii infection in a mouse model.
Shellito JE, Kolls JK, Olariu R, Beck JM
J Infect Dis. 1996
PubMed ID: 8568306
The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains.
Schubert U, Bour S, Ferrer-Montiel AV, Montal M, Maldarell F, Strebel K
J Virol. 1996
PubMed ID: 8551619
Cooperative effects of the human immunodeficiency virus type 1 envelope variable loops V1 and V3 in mediating infectivity for T cells.
Carrillo A, Ratner L
J Virol. 1996
PubMed ID: 8551601
Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1.
Trkola A, Purtscher M, Muster T, Ballaun C, Buchacher A, Sullivan N, Srinivasan K, Sodroski J, Moore JP, Katinger H
J Virol. 1996
PubMed ID: 8551569
CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge.
von Herrath MG, Yokoyama M, Dockter J, Oldstone MB, Whitton JL
J Virol. 1996
PubMed ID: 8551565
Glycosylation and stability of mature HIV envelope glycoprotein conformation under various conditions.
Papandreou MJ, Idziorek T, Miquelis R, Fenouillet E
FEBS Lett. 1996
PubMed ID: 8635586
Coexpression of a nonsyncytium inducer HIV-1 glycoprotein inhibits syncytium formation by another HIV-1 Env protein.
Li YY, O'Donnell MA, Perez LG
Virology. 1996
PubMed ID: 8560767
N-linked glycans in the CD4-binding domain of human immunodeficiency virus type 1 envelope glycoprotein gp160 are essential for the in vivo priming of T cells recognizing an epitope located in their vicinity.
Sjölander S, Bolmstedt A, Akerblom L, Horal P, Olofsson S, Morein B, Sjölander A
Virology. 1996
PubMed ID: 8560759
Conserved N-linked oligosaccharides of the C-terminal portion of human immunodeficiency virus type 1 gp120 and viral susceptibility to neutralizing antibodies.
Hemming A, Gram GJ, Bolmstedt A, Losman B, Hansen JE, Ricksten A, Olofsson S
Arch Virol. 1996
PubMed ID: 8973529
Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes.
Li T, Ramirez K, Palacios R
Cell Growth Differ. 1996
PubMed ID: 8788039
Chromosomal localization of the genes encoding rat CD4, CD8alpha, and CD8beta.
Dissen E, Fossum S
Immunogenetics. 1996
PubMed ID: 8753864
Conformation of the HIV-1 gp 120 envelope glycoprotein.
Sodroski J, Wyatt R, Olshevsky U, Olshevsky V, Moore J
Antibiot Chemother. 1996
PubMed ID: 8726523
Genetic variability of the human CD4 V2 domain.
Indraccolo S, Mion M, Biagiotti R, Romagnani S, Morfini M, Longo G, Zamarchi R, Chieco-Bianchi L, Amadori A
Immunogenetics. 1996
PubMed ID: 8613144
The role of CD4 in HIV envelope-mediated pathogenesis.
Siliciano RF
Curr Top Microbiol Immunol. 1996
PubMed ID: 8575195
A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis.
Chu K, Niu X, Williams LT
Proc Natl Acad Sci U S A. 1995
PubMed ID: 8524870
Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor.
Yao Z, Fanslow WC, Seldin MF, Rousseau AM, Painter SL, Comeau MR, Cohen JI, Spriggs MK
Immunity. 1995
PubMed ID: 8777726
Differential patterns of T-cell receptor BV-specific activation of T cells by gp120 from different HIV strains.
Akolkar PN, Gulwani-Akolkar B, Silver J
Scand J Immunol. 1995
PubMed ID: 8552983
Mapping the Ig superantigen-binding site of HIV-1 gp120.
Goodglick L, Zevit N, Neshat MS, Braun J
J Immunol. 1995
PubMed ID: 7594524
Syk tyrosine kinase required for mouse viability and B-cell development.
Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T
Nature. 1995
PubMed ID: 7477353
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk.
Turner M, Mee PJ, Costello PS, Williams O, Price AA, Duddy LP, Furlong MT, Geahlen RL, Tybulewicz VL
Nature. 1995
PubMed ID: 7477352
The role of human immunodeficiency virus type 1 envelope glycoproteins in virus infection.
Freed EO, Martin MA
J Biol Chem. 1995
PubMed ID: 7592573
An anchored molecular map of mouse chromosome 6 with an analysis of interference.
Davies PO, Melanitou E, Asano M, Avner PR, Montagutelli X
Mamm Genome. 1995
PubMed ID: 8563173
The CD4 receptor plays essential but distinct roles in HIV-1 infection and induction of apoptosis in primary bone marrow GPIIb/IIIa+ megakaryocytes and the HEL cell line.
Zauli G, Catani L, Gibellini D, Re MC, Milani D, Borgatti P, Bassini A, La Placa M, Capitani S
Br J Haematol. 1995
PubMed ID: 8547064
Ligation of either CD2 or CD28 rescues CD4+ T cells from HIV-gp120-induced apoptosis.
Tuosto L, Piazza C, Moretti S, Modesti A, Greenlaw R, Lechler R, Lombardi G, Piccolella E
Eur J Immunol. 1995
PubMed ID: 7589092
Differential susceptibility to monomeric HIV gp120-mediated apoptosis in antigen-activated CD4+ T cell populations.
Tuosto L, Gilardini Montani MS, Lorenzetti S, Cundari E, Moretti S, Lombardi G, Piccolella E
Eur J Immunol. 1995
PubMed ID: 7589091
Structural modulations of the envelope gp120 glycoprotein of human immunodeficiency virus type 1 upon oligomerization and differential V3 loop epitope exposure of isolates displaying distinct tropism upon virion-soluble receptor binding.
Stamatatos L, Cheng-Mayer C
J Virol. 1995
PubMed ID: 7545244
Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules.
Golding H, Dimitrov DS, Manischewitz J, Broder CC, Robinson J, Fabian S, Littman DR, Lapham CK
J Virol. 1995
PubMed ID: 7545243
Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin-specific protective immunity despite normal gut mucosal IgA differentiation.
Hörnquist CE, Ekman L, Grdic KD, Schön K, Lycke NY
J Immunol. 1995
PubMed ID: 7673704
Polyomavirus persists in CD4/8 double-knockout, but not in CD4 or CD8 single-knockout mice.
Berke Z, Wen T, Jin S, Klein G, Dalianis T
Virology. 1995
PubMed ID: 7676644
Interaction of p56lck with CD4 in the yeast two-hybrid system.
Campbell KS, Buder A, Deuschle U
Ann N Y Acad Sci. 1995
PubMed ID: 7486703
HLA-DR polymorphism affects the interaction with CD4.
Fleury S, Thibodeau J, Croteau G, Labrecque N, Aronson HE, Cantin C, Long EO, Sékaly RP
J Exp Med. 1995
PubMed ID: 7650480
Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis.
Simpson SJ, Mizoguchi E, Allen D, Bhan AK, Terhorst C
Eur J Immunol. 1995
PubMed ID: 7589135
Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells.
Koh DR, Ho A, Rahemtulla A, Fung-Leung WP, Griesser H, Mak TW
Eur J Immunol. 1995
PubMed ID: 7589126
Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding.
Wyatt R, Moore J, Accola M, Desjardin E, Robinson J, Sodroski J
J Virol. 1995
PubMed ID: 7543586
Monoclonal antibodies raised against covalently crosslinked complexes of human immunodeficiency virus type 1 gp120 and CD4 receptor identify a novel complex-dependent epitope on gp 120.
DeVico AL, Rahman R, Welch J, Crowley R, Lusso P, Sarngadharan MG, Pal R
Virology. 1995
PubMed ID: 7544051
Essential role for ZAP-70 in both positive and negative selection of thymocytes.
Negishi I, Motoyama N, Nakayama K, Nakayama K, Senju S, Hatakeyama S, Zhang Q, Chan AC, Loh DY
Nature. 1995
PubMed ID: 7630421
Interactions between the amino-terminal domain of p56lck and cytoplasmic domains of CD4 and CD8 alpha in yeast.
Campbell KS, Buder A, Deuschle U
Eur J Immunol. 1995
PubMed ID: 7664803
Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82.
Imai T, Kakizaki M, Nishimura M, Yoshie O
J Immunol. 1995
PubMed ID: 7636191
Investigation of the structural components governing the polarity-dependent refolding of a CD4-binding peptide from gp120.
Graf von Stosch A, Kinzel V, Pipkorn R, Reed J
J Mol Biol. 1995
PubMed ID: 7616571
Localization of the synapsin II (SYN2) gene to human chromosome 3 and mouse chromosome 6.
Li L, Chin LS, Greengard P, Copeland NG, Gilbert DJ, Jenkins NA
Genomics. 1995
PubMed ID: 8530057
HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71).
Chirmule N, McCloskey TW, Hu R, Kalyanaraman VS, Pahwa S
J Immunol. 1995
PubMed ID: 7541827
Amino acid substitutions in the V3 loop are responsible for adaptation to growth in transformed T-cell lines of a primary human immunodeficiency virus type 1.
Harrowe G, Cheng-Mayer C
Virology. 1995
PubMed ID: 7618285
Synergistic inhibition of human immunodeficiency virus type 1 envelope glycoprotein-mediated cell fusion and infection by an antibody to CD4 domain 2 in combination with anti-gp120 antibodies.
Burkly L, Mulrey N, Blumenthal R, Dimitrov DS
J Virol. 1995
PubMed ID: 7769687
Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.
Goldsmith MA, Warmerdam MT, Atchison RE, Miller MD, Greene WC
J Virol. 1995
PubMed ID: 7769669
Enhancing the avidity of a human recombinant anti-HIV-1 monoclonal antibody through oligomerization.
Tsai PK, Burke CJ, Irwin JW, Bruner MW, Tung JS, Hollis GF, Mark GE, Kessler JA, Boots LJ, Conley AJ
J Pharm Sci. 1995
PubMed ID: 7562439
Contribution of hypervariable domains to the conformation of a broadly neutralizing glycoprotein 120 epitope.
Lee CN, Robinson J, Mazzara G, Cheng YL, Essex M, Lee TH
AIDS Res Hum Retroviruses. 1995
PubMed ID: 7546903
Degradation of CD4 induced by human immunodeficiency virus type 1 Vpu protein: a predicted alpha-helix structure in the proximal cytoplasmic region of CD4 contributes to Vpu sensitivity.
Yao XJ, Friborg J, Checroune F, Gratton S, Boisvert F, Sékaly RP, Cohen EA
Virology. 1995
PubMed ID: 7778293
gp120-induced programmed cell death in recently activated T cells without subsequent ligation of the T cell receptor.
Foster S, Beverley P, Aspinall R
Eur J Immunol. 1995
PubMed ID: 7615007
Membrane-interactive phospholipids inhibit HIV type 1-induced cell fusion and surface gp160/gp120 binding to monoclonal antibody.
Krugner-Higby L, Goff D, Edwards T, Iyer N, Neufeld J, Kute T, Morris-Natschke S, Ishaq K, Piantadosi C, Kucera LS
AIDS Res Hum Retroviruses. 1995
PubMed ID: 7576930
Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex.
Thome M, Duplay P, Guttinger M, Acuto O
J Exp Med. 1995
PubMed ID: 7539035
HIV-1 glycoprotein gp120 disrupts CD4-p56lck/CD3-T cell receptor interactions and inhibits CD3 signaling.
Hubert P, Bismuth G, Körner M, Debré P
Eur J Immunol. 1995
PubMed ID: 7774645
Adaptation of human immunodeficiency virus type 1 to cells expressing a binding-deficient CD4 mutant (lysine 46 to aspartic acid).
Choe HR, Sodroski J
J Virol. 1995
PubMed ID: 7707502
[Nucleotide sequence of two exons of the human T-lymphocyte CD4 receptor gene]
Zverev VV, Sidorov AV, Nedospasov SA, Maliushova VV, Udalova IA, Andzhaparizde OG, Blinov VM
Vopr Virusol. 1995
PubMed ID: 7676667
Single basic amino acid substitutions at position 302 or 320 in the V3 domain of HIV type 1 are not sufficient to alter the antiviral activity of dextran sulfate and heparin.
Okada T, Gurney ME
AIDS Res Hum Retroviruses. 1995
PubMed ID: 7576913
Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120.
Dianzani U, Bragardo M, Buonfiglio D, Redoglia V, Funaro A, Portoles P, Rojo J, Malavasi F, Pileri A
Eur J Immunol. 1995
PubMed ID: 7539755
Inhibition of anti-V3 domain antibody binding to human immunodeficiency virus type-1-infected cells by sulfated polysaccharides.
Okada T, Patterson BK, Gurney ME
Biochem Biophys Res Commun. 1995
PubMed ID: 7537501
Chromosomal localization of the gene encoding the human DNA helicase RECQL and its mouse homologue.
Puranam KL, Kennington E, Sait SN, Shows TB, Rochelle JM, Seldin MF, Blackshear PJ
Genomics. 1995
PubMed ID: 7607686
Intrathymic T cell receptor (TcR) targeting in mice lacking CD4 or major histocompatibility complex (MHC) class II: rescue of CD4 T cell lineage without co-engagement of TcR/CD4 by MHC class II.
Müller KP, Kyewski BA
Eur J Immunol. 1995
PubMed ID: 7737291
Simple strategy to induce antibodies of distinct specificity: application to the mapping of gp120 and inhibition of HIV-1 infectivity.
Prieto I, Hervás-Stubbs S, García-Granero M, Berasain C, Riezu-Boj JI, Lasarte JJ, Sarobe P, Prieto J, Borrás-Cuesta F
Eur J Immunol. 1995
PubMed ID: 7737288
Activation of virus-specific major histocompatibility complex class II-restricted CD8+ cytotoxic T cells in CD4-deficient mice.
Heemskerk MH, Schilham MW, Schoemaker HM, Spierenburg G, Spaan WJ, Boog CJ
Eur J Immunol. 1995
PubMed ID: 7737281
Characterization of neutralization epitopes in the V2 region of human immunodeficiency virus type 1 gp120: role of glycosylation in the correct folding of the V1/V2 domain.
Wu Z, Kayman SC, Honnen W, Revesz K, Chen H, Vijh-Warrier S, Tilley SA, McKeating J, Shotton C, Pinter A
J Virol. 1995
PubMed ID: 7533854
Productive infection and subsequent interaction of CD4-gp120 at the cellular membrane is required for HIV-induced apoptosis of CD4+ T cells.
Corbeil J, Richman DD
J Gen Virol. 1995
PubMed ID: 7897356
A monoclonal antibody to the gp120-CD4 complex has differential effect on HIV-induced syncytium formation and viral infectivity.
Konopka K, Pretzer E, Celada F, Düzgüneş N
J Gen Virol. 1995
PubMed ID: 7897355
IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation.
Radrizzani M, Accornero P, Amidei A, Aiello A, Delia D, Kurrle R, Colombo MP
Cell Immunol. 1995
PubMed ID: 7867080
The human immunodeficiency virus type 1 Vpu protein specifically binds to the cytoplasmic domain of CD4: implications for the mechanism of degradation.
Bour S, Schubert U, Strebel K
J Virol. 1995
PubMed ID: 7853484
Temperature dependence of cell-cell fusion induced by the envelope glycoprotein of human immunodeficiency virus type 1.
Frey S, Marsh M, Günther S, Pelchen-Matthews A, Stephens P, Ortlepp S, Stegmann T
J Virol. 1995
PubMed ID: 7853478
HIV-1 Nef protein downregulation of CD4 surface expression: relevance of the lck binding domain of CD4.
Bandres JC, Shaw AS, Ratner L
Virology. 1995
PubMed ID: 7871751
Outcome of infection with different strains of Trypanosoma cruzi in mice lacking CD4 and/or CD8.
Rottenberg ME, Riarte A, Sporrong L, Altcheh J, Petray P, Ruiz AM, Wigzell H, Orn A
Immunol Lett. 1995
PubMed ID: 7622189
Molecular structure and function of CD4 on murine egg plasma membrane.
Guo MW, Watanabe T, Mori E, Mori T
Zygote. 1995
PubMed ID: 7613876
Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail.
Salghetti S, Mariani R, Skowronski J
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7831289
Neutralizing recombinant human antibodies to a conformational V2- and CD4-binding site-sensitive epitope of HIV-1 gp120 isolated by using an epitope-masking procedure.
Ditzel HJ, Binley JM, Moore JP, Sodroski J, Sullivan N, Sawyer LS, Hendry RM, Yang WP, Barbas CF, Burton DR
J Immunol. 1995
PubMed ID: 7529290
Multibranched peptide constructs derived from the V3 loop of envelope glycoprotein gp120 inhibit human immunodeficiency virus type 1 infection through interaction with CD4.
Benjouad A, Chapuis F, Fenouillet E, Gluckman JC
Virology. 1995
PubMed ID: 7831801
Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
Schwartz O, Dautry-Varsat A, Goud B, Maréchal V, Subtil A, Heard JM, Danos O
J Virol. 1995
PubMed ID: 7983750
Membrane-expressed HIV envelope glycoprotein heterodimer is a powerful inducer of cell death in uninfected CD4+ target cells.
Laurent-Crawford AG, Coccia E, Krust B, Hovanessian AG
Res Virol. 1995
PubMed ID: 7754236
Bathophenanthroline disulfonate and soluble CD4 as probes for early events of HIV type 1 entry.
Demaria S, Tilley SA, Pinter A, Bushkin Y
AIDS Res Hum Retroviruses. 1995
PubMed ID: 7734186
Mapping of the genes for four members of the transmembrane 4 superfamily: mouse Cd9, Cd63, Cd81, and Cd82.
Seldin MF, Rochelle JM, Tomlinson MG, Wright MD
Immunogenetics. 1995
PubMed ID: 7590978
Binding of HIV-1 gp120 to an anti-V3 loop antibody reveals novel antigen-induced epitopes.
Denisova G, Zwickel J, Gershoni JM
FASEB J. 1995
PubMed ID: 7529735
Antibody responses raised against a conformational V3 loop peptide of HIV-1.
Bukawa H, Fukushima J, Hamajima K, Kimura M, Tsuji T, Xin KQ, Okuda K
Microbiol Immunol. 1995
PubMed ID: 7494500
Are CD4 and Fas peptide identities of gp120 relevant to the molecular basis of AIDS pathogenesis?
Zagury JF, Chams V, Lachgar A, Achour A, Bizzini B, Burny A, Zagury D, Feldman M
Cell Death Differ. 1995
PubMed ID: 17180012
Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic.
Benichou S, Bomsel M, Bodéus M, Durand H, Douté M, Letourneur F, Camonis J, Benarous R
J Biol Chem. 1994
PubMed ID: 7982906
Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1.
Little SJ, Riggs NL, Chowers MY, Fitch NJ, Richman DD, Spina CA, Guatelli JC
Virology. 1994
PubMed ID: 7975260
CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse.
Blair PJ, Bultman SJ, Haas JC, Rouse BT, Wilkinson JE, Godfrey VL
J Immunol. 1994
PubMed ID: 7930593
Stimulation of heterologous protein degradation by the Vpu protein of HIV-1 requires the transmembrane and cytoplasmic domains of CD4.
Buonocore L, Turi TG, Crise B, Rose JK
Virology. 1994
PubMed ID: 8091684
Vpu-mediated proteolysis of gp160/CD4 chimeric envelope glycoproteins in the endoplasmic reticulum: requirement of both the anchor and cytoplasmic domains of CD4.
Raja NU, Vincent MJ, abdul Jabbar M
Virology. 1994
PubMed ID: 8091666
Structural characterization of broadly neutralizing human monoclonal antibodies against the CD4 binding site of HIV-1 gp120.
Bagley J, Dillon PJ, Rosen C, Robinson J, Sodroski J, Marasco WA
Mol Immunol. 1994
PubMed ID: 7935503
gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation.
Goldman F, Jensen WA, Johnson GL, Heasley L, Cambier JC
J Immunol. 1994
PubMed ID: 7522245
Experimental allergic encephalomyelitis (EAE) in mice lacking CD4+ T cells.
Koh DR, Ho A, Rahemtulla A, Penninger J, Mak TW
Eur J Immunol. 1994
PubMed ID: 7916298
Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice.
Rahemtulla A, Kündig TM, Narendran A, Bachmann MF, Julius M, Paige CJ, Ohashi PS, Zinkernagel RM, Mak TW
Eur J Immunol. 1994
PubMed ID: 7916297
CD4 modulation of noninfected human T lymphocytes by HIV-1 envelope glycoprotein gp120: contribution to the immunosuppression seen in HIV-1 infection by induction of CD4 and CD3 unresponsiveness.
Theodore AC, Kornfeld H, Wallace RP, Cruikshank WW
J Acquir Immune Defic Syndr. 1994
PubMed ID: 7914230
Sulfated polyanions prevent HIV infection of lymphocytes by disruption of the CD4-gp120 interaction, but do not inhibit monocyte infection.
Lynch G, Low L, Li S, Sloane A, Adams S, Parish C, Kemp B, Cunningham AL
J Leukoc Biol. 1994
PubMed ID: 7521897
Myristoylation-dependent binding of HIV-1 Nef to CD4.
Harris MP, Neil JC
J Mol Biol. 1994
PubMed ID: 8057354
A transcriptional silencer controls the developmental expression of the CD4 gene.
Siu G, Wurster AL, Duncan DD, Soliman TM, Hedrick SM
EMBO J. 1994
PubMed ID: 8062832
Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.
Rhee SS, Marsh JW
J Virol. 1994
PubMed ID: 8035515
CD4+ T cells from collagen-induced arthritic mice are essential to transfer arthritis into severe combined immunodeficient mice.
Kadowaki KM, Matsuno H, Tsuji H, Tunru I
Clin Exp Immunol. 1994
PubMed ID: 7914155
The role of CD4 and its downmodulation in establishment and maintenance of HIV-1 infection.
Bour S, Geleziunas R, Wainberg MA
Immunol Rev. 1994
PubMed ID: 7821926
Deletion of T lymphocytes in human CD4 transgenic mice induced by HIV-gp120 and gp120-specific antibodies from AIDS patients.
Wang ZQ, Orlikowsky T, Dudhane A, Mittler R, Blum M, Lacy E, Riethmüller G, Hoffmann MK
Eur J Immunol. 1994
PubMed ID: 7913036
Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice.
Battegay M, Moskophidis D, Rahemtulla A, Hengartner H, Mak TW, Zinkernagel RM
J Virol. 1994
PubMed ID: 7911534
Amino acid substitutions in the human immunodeficiency virus type 1 gp120 V3 loop that change viral tropism also alter physical and functional properties of the virion envelope.
Willey RL, Theodore TS, Martin MA
J Virol. 1994
PubMed ID: 7515973
A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development.
Sawada S, Scarborough JD, Killeen N, Littman DR
Cell. 1994
PubMed ID: 8004678
Jacalin, a lectin with anti-HIV-1 properties, and HIV-1 gp120 envelope protein interact with distinct regions of the CD4 molecule.
Corbeau P, Haran M, Binz H, Devaux C
Mol Immunol. 1994
PubMed ID: 8196669
CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
Rajan TV, Nelson FK, Killeen N, Shultz LD, Yates JA, Bailis JM, Littman DR, Greiner DL
Exp Parasitol. 1994
PubMed ID: 7911434
A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice.
Wallace VA, Kondo S, Kono T, Xing Z, Timms E, Furlonger C, Keystone E, Gauldie J, Sauder DN, Mak TW
Eur J Immunol. 1994
PubMed ID: 7911425
Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression.
Cruikshank WW, Center DM, Nisar N, Wu M, Natke B, Theodore AC, Kornfeld H
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7910967
The difference in gp160 and gp120 of HIV type 1 in the induction of CD4 downregulation preceding single-cell killing.
Koga Y, Nakamura K, Sasaki M, Kimura G, Nomoto K
Virology. 1994
PubMed ID: 8178478
The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef.
Anderson SJ, Lenburg M, Landau NR, Garcia JV
J Virol. 1994
PubMed ID: 8151774
CD4 and CD8 expression by human and mouse thymic dendritic cells.
Winkel K, Sotzik F, Vremec D, Cameron PU, Shortman K
Immunol Lett. 1994
PubMed ID: 8088877
Understanding the CD4 molecule: surface expression and function.
Morrison WJ, Offner H, Vandenbark AA
J Neurosci Res. 1994
PubMed ID: 8057386
Intracellular membrane traffic of human immunodeficiency virus type 1 envelope glycoproteins: vpu liberates Golgi-targeted gp160 from CD4-dependent retention in the endoplasmic reticulum.
Kimura T, Nishikawa M, Ohyama A
J Biochem. 1994
PubMed ID: 7961587
Adhesion mediated by intercellular adhesion molecule 1 attenuates the potency of antibodies that block HIV-1 gp160-dependent syncytium formation.
Berman PW, Nakamura GR
AIDS Res Hum Retroviruses. 1994
PubMed ID: 7917519
Histoincompatibility-associated differences in the phenotypes of murine cardiac allograft infiltrating T cells.
Carlquist JF, Shelby J, Hammond EH, Greenwood JH, Anderson JL
Immunology. 1994
PubMed ID: 7913913
Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.
Ho WY, Cooke MP, Goodnow CC, Davis MM
J Exp Med. 1994
PubMed ID: 7909325
CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus.
Lusso P, Secchiero P, Crowley RW, Garzino-Demo A, Berneman ZN, Gallo RC
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7909607
Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help.
Chirmule N, Wang XP, Hu R, Oyaizu N, Roifman C, Pahwa R, Kalyanaraman VS, Pahwa S
Cell Immunol. 1994
PubMed ID: 8168144
Correlation between high level gp160 expression and reduced CD4 biosynthesis in clonal derivatives of human immunodeficiency virus type 1-infected U-937 cells.
Geleziunas R, Bour S, Wainberg MA
J Gen Virol. 1994
PubMed ID: 8151301
Analysis of the human immunodeficiency virus type 1 envelope protein interaction with the CD4 host cell receptor.
Malvoisin E, Wild F
J Gen Virol. 1994
PubMed ID: 8151300
Human CD4 restores normal T cell development and function in mice deficient in murine CD4.
Law YM, Yeung RS, Mamalaki C, Kioussis D, Mak TW, Flavell RA
J Exp Med. 1994
PubMed ID: 8145040
Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments.
Schubert U, Strebel K
J Virol. 1994
PubMed ID: 8139011
Functional role of the V1/V2 region of human immunodeficiency virus type 1 envelope glycoprotein gp120 in infection of primary macrophages and soluble CD4 neutralization.
Koito A, Harrowe G, Levy JA, Cheng-Mayer C
J Virol. 1994
PubMed ID: 8139010
Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome.
Lock LF, Gilbert DJ, Street VA, Migeon MB, Jenkins NA, Copeland NG, Tempel BL
Genomics. 1994
PubMed ID: 8034307
Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.
Aiken C, Konner J, Landau NR, Lenburg ME, Trono D
Cell. 1994
PubMed ID: 8124721
An N-glycan within the human immunodeficiency virus type 1 gp120 V3 loop affects virus neutralization.
Back NK, Smit L, De Jong JJ, Keulen W, Schutten M, Goudsmit J, Tersmette M
Virology. 1994
PubMed ID: 8122371
The phorbol ester phorbol myristate acetate inhibits human immunodeficiency virus type 1 envelope-mediated fusion by modulating an accessory component(s) in CD4-expressing cells.
Golding H, Manischewitz J, Vujcic L, Blumenthal R, Dimitrov DS
J Virol. 1994
PubMed ID: 7906314
HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A.
Amendola A, Lombardi G, Oliverio S, Colizzi V, Piacentini M
FEBS Lett. 1994
PubMed ID: 7906657
The mouse CD69 gene. Structure, expression, and mapping to the NK gene complex.
Ziegler SF, Levin SD, Johnson L, Copeland NG, Gilbert DJ, Jenkins NA, Baker E, Sutherland GR, Feldhaus AL, Ramsdell F
J Immunol. 1994
PubMed ID: 8301128
Sequences present in the cytoplasmic domain of CD4 are necessary and sufficient to confer sensitivity to the human immunodeficiency virus type 1 Vpu protein.
Willey RL, Buckler-White A, Strebel K
J Virol. 1994
PubMed ID: 8289353
Functions of HIV envelope glycans.
Fenouillet E, Gluckman JC, Jones IM
Trends Biochem Sci. 1994
PubMed ID: 8160267
Heparin specifically inhibits binding of V3 loop antibodies to HIV-1 gp120, an effect potentiated by CD4 binding.
Harrop HA, Coombe DR, Rider CC
AIDS. 1994
PubMed ID: 8043225
Increase in soluble CD4 binding to and CD4-induced dissociation of gp120 from virions correlates with infectivity of human immunodeficiency virus type 1.
Willey RL, Martin MA, Peden KW
J Virol. 1994
PubMed ID: 7904656
Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices.
Ryu SE, Truneh A, Sweet RW, Hendrickson WA
Structure. 1994
PubMed ID: 8075984
Identification of three N-linked glycans in the V4-V5 region of HIV-1 gp 120, dispensable for CD4-binding and fusion activity of gp 120.
Hemming A, Bolmstedt A, Jansson B, Hansen JE, Travis B, Hu SL, Olofsson S
Arch Virol. 1994
PubMed ID: 8129620
Nef 27, but not the Nef 25 isoform of human immunodeficiency virus-type 1 pNL4.3 down-regulates surface CD4 and IL-2R expression in peripheral blood mononuclear cells and transformed T cells.
Greenway AL, McPhee DA, Grgacic E, Hewish D, Lucantoni A, Macreadie I, Azad A
Virology. 1994
PubMed ID: 7903128
gp120-mediated alterations in astrocyte ion transport.
Benos DJ, Hahn BH, Shaw GM, Bubien JK, Benveniste EN
Adv Neuroimmunol. 1994
PubMed ID: 7874384
Identification of an N-linked glycan in the V1-loop of HIV-1 gp120 influencing neutralization by anti-V3 antibodies and soluble CD4.
Gram GJ, Hemming A, Bolmstedt A, Jansson B, Olofsson S, Akerblom L, Nielsen JO, Hansen JE
Arch Virol. 1994
PubMed ID: 7832633
Apoptosis induced in CD4+ cells expressing gp160 of human immunodeficiency virus type 1.
Lu YY, Koga Y, Tanaka K, Sasaki M, Kimura G, Nomoto K
J Virol. 1994
PubMed ID: 7504739
T cell activation antigen, CD26, as a cofactor for entry of HIV in CD4+ cells.
Callebaut C, Krust B, Jacotot E, Hovanessian AG
Science. 1993
PubMed ID: 7903479
CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.
Brady HJ, Pennington DJ, Miles CG, Dzierzak EA
EMBO J. 1993
PubMed ID: 8262036
Normal T cell receptor-mediated signaling in T cell lines stably expressing HIV-1 envelope glycoproteins.
Tani Y, Tian H, Lane HC, Cohen DI
J Immunol. 1993
PubMed ID: 7903106
Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.
Prasad KV, Kapeller R, Janssen O, Repke H, Duke-Cohan JS, Cantley LC, Rudd CE
Mol Cell Biol. 1993
PubMed ID: 8246987
Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4.
Lenburg ME, Landau NR
J Virol. 1993
PubMed ID: 8230446
Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei.
Rottenberg ME, Bakhiet M, Olsson T, Kristensson K, Mak T, Wigzell H, Orn A
Infect Immun. 1993
PubMed ID: 8225589
Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding.
Sattentau QJ, Moore JP, Vignaux F, Traincard F, Poignard P
J Virol. 1993
PubMed ID: 7693970
Cell fusion mediated by interaction of a hybrid CD4.CD8 molecule with the human immunodeficiency virus type 1 envelope glycoprotein does occur after a long lag time.
Golding H, Blumenthal R, Manischewitz J, Littman DR, Dimitrov DS
J Virol. 1993
PubMed ID: 8411350
The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]
Penninger JM, Neu N, Timms E, Wallace VA, Koh DR, Kishihara K, Pummerer C, Mak TW
J Exp Med. 1993
PubMed ID: 8228830
Synergistic inhibition of HIV-1 by CD4 binding domain reagents and V3-directed monoclonal antibodies.
Potts BJ, Field KG, Wu Y, Posner M, Cavacini L, White-Scharf M
Virology. 1993
PubMed ID: 8212576
Elimination of HIV-infected cells by lymphocytes armed with a bifunctional antibody to gp120 of HIV and CD3.
Okada H, Momota H, Okada N, Okamoto T, Azuma T
Immunol Lett. 1993
PubMed ID: 8125527
Inhibition of human immunodeficiency virus type 1 infection and syncytium formation in human cells by V3 loop synthetic peptides from gp120.
Nehete PN, Arlinghaus RB, Sastry KJ
J Virol. 1993
PubMed ID: 7692087
The recognition of chimeras of rat and human CD4 by HIV-1 gp120 and by monoclonal antibodies.
Davis SJ, James WS, Schockmel GA, Simon JH, Somoza C
Philos Trans R Soc Lond B Biol Sci. 1993
PubMed ID: 7904351
The role of CD4 in HIV binding and entry.
Sattentau QJ, Moore JP
Philos Trans R Soc Lond B Biol Sci. 1993
PubMed ID: 7904348
CD4 negative mice as a model for immunodeficiency.
Rahemtulla A, Shahinian A, Kundig T, Zinkernagel R, Mak TW
Philos Trans R Soc Lond B Biol Sci. 1993
PubMed ID: 7904347
Activation-dependent apoptosis in CD4+ T cells during murine AIDS.
Cohen DA, Fitzpatrick EA, Barve SS, Guthridge JM, Jacob RJ, Simmerman L, Kaplan AM
Cell Immunol. 1993
PubMed ID: 8104712
Analysis of endoproteolytic cleavage and intracellular transport of human immunodeficiency virus type 1 envelope glycoproteins using mutant CD4 molecules bearing the transmembrane endoplasmic reticulum retention signal.
Raja NU, Vincent MJ, Jabbar MA
J Gen Virol. 1993
PubMed ID: 8409933
Role of HIV-1 envelope V3 loop cleavage in cell tropism.
Gu R, Westervelt P, Ratner L
AIDS Res Hum Retroviruses. 1993
PubMed ID: 8280475
The association of the protein tyrosine kinases p56lck and p60fyn with the glycosyl phosphatidylinositol-anchored proteins Thy-1 and CD48 in rat thymocytes is dependent on the state of cellular activation.
Garnett D, Barclay AN, Carmo AM, Beyers AD
Eur J Immunol. 1993
PubMed ID: 8104794
Loss of serum antibodies to a conformational epitope of HIV-1/gp120 identified by a human monoclonal antibody is associated with disease progression.
Cavacini LA, Emes CL, Power J, Underdahl J, Goldstein R, Mayer K, Posner MR
J Acquir Immune Defic Syndr. 1993
PubMed ID: 7692037
Probing the structure of the V2 domain of human immunodeficiency virus type 1 surface glycoprotein gp120 with a panel of eight monoclonal antibodies: human immune response to the V1 and V2 domains.
Moore JP, Sattentau QJ, Yoshiyama H, Thali M, Charles M, Sullivan N, Poon SW, Fung MS, Traincard F, Pinkus M
J Virol. 1993
PubMed ID: 7690418
Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120.
Oravecz T, Norcross MA
AIDS Res Hum Retroviruses. 1993
PubMed ID: 7506554
Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice.
Locksley RM, Reiner SL, Hatam F, Littman DR, Killeen N
Science. 1993
PubMed ID: 8367726
Human immunodeficiency virus type 1 Vpu protein induces degradation of chimeric envelope glycoproteins bearing the cytoplasmic and anchor domains of CD4: role of the cytoplasmic domain in Vpu-induced degradation in the endoplasmic reticulum.
Vincent MJ, Raja NU, Jabbar MA
J Virol. 1993
PubMed ID: 8350411
Down-regulation of CD4 molecules by the expression of Nef: a quantitative analysis of CD4 antigens on the cell surfaces.
Inoue M, Koga Y, Djordjijevic D, Fukuma T, Reddy EP, Yokoyama MM, Sagawa K
Int Immunol. 1993
PubMed ID: 7902127
HIV binding to its receptor creates specific epitopes for the CD4/gp120 complex.
Gershoni JM, Denisova G, Raviv D, Smorodinsky NI, Buyaner D
FASEB J. 1993
PubMed ID: 7690724
Conformational changes affecting the V3 and CD4-binding domains of human immunodeficiency virus type 1 gp120 associated with env processing and with binding of ligands to these sites.
Pinter A, Honnen WJ, Tilley SA
J Virol. 1993
PubMed ID: 7688827
Helper T-cell development in the absence of CD4-p56lck association.
Killeen N, Littman DR
Nature. 1993
PubMed ID: 8355789
Identification of CD4 and major histocompatibility complex functional peptide sites and their homology with oligopeptides from human immunodeficiency virus type 1 glycoprotein gp120: role in AIDS pathogenesis.
Zagury JF, Bernard J, Achour A, Astgen A, Lachgar A, Fall L, Carelli C, Issing W, Mbika JP, Picard O
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8356059
Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells.
Anderson S, Shugars DC, Swanstrom R, Garcia JV
J Virol. 1993
PubMed ID: 8331733
Functional and immunologic characterization of human immunodeficiency virus type 1 envelope glycoproteins containing deletions of the major variable regions.
Wyatt R, Sullivan N, Thali M, Repke H, Ho D, Robinson J, Posner M, Sodroski J
J Virol. 1993
PubMed ID: 8331723
Membrane expression of HIV envelope glycoproteins triggers apoptosis in CD4 cells.
Laurent-Crawford AG, Krust B, Rivière Y, Desgranges C, Muller S, Kieny MP, Dauguet C, Hovanessian AG
AIDS Res Hum Retroviruses. 1993
PubMed ID: 8105835
CD4-derived peptide and sulfated polysaccharides have similar mechanisms of anti-HIV activity based on electrostatic interactions with positively charged gp120 fragments.
Meshcheryakova D, Andreev S, Tarasova S, Sidorova M, Vafina M, Kornilaeva G, Karamov E, Khaitov R
Mol Immunol. 1993
PubMed ID: 8102473
Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120.
McKeating JA, Shotton C, Cordell J, Graham S, Balfe P, Sullivan N, Charles M, Page M, Bolmstedt A, Olofsson S
J Virol. 1993
PubMed ID: 7687306
Differential T cell costimulatory requirements in CD28-deficient mice.
Shahinian A, Pfeffer K, Lee KP, Kündig TM, Kishihara K, Wakeham A, Kawai K, Ohashi PS, Thompson CB, Mak TW
Science. 1993
PubMed ID: 7688139
Human immunodeficiency virus type 1 Vpu protein induces degradation of CD4 in vitro: the cytoplasmic domain of CD4 contributes to Vpu sensitivity.
Chen MY, Maldarelli F, Karczewski MK, Willey RL, Strebel K
J Virol. 1993
PubMed ID: 8510209
Physicochemical dissociation of CD4-mediated syncytium formation and shedding of human immunodeficiency virus type 1 gp120.
Fu YK, Hart TK, Jonak ZL, Bugelski PJ
J Virol. 1993
PubMed ID: 8510207
Synergistic inhibition of HIV-1 envelope-mediated cell fusion by CD4-based molecules in combination with antibodies to gp120 or gp41.
Allaway GP, Ryder AM, Beaudry GA, Maddon PJ
AIDS Res Hum Retroviruses. 1993
PubMed ID: 8369162
Positive-negative selection gene targeting with the diphtheria toxin A-chain gene in mouse embryonic stem cells.
McCarrick JW, Parnes JR, Seong RH, Solter D, Knowles BB
Transgenic Res. 1993
PubMed ID: 8364601
Further characterization of an antigenic site of HIV-1 gp120 recognized by virus neutralizing human monoclonal antibodies.
Schutten M, McKnight A, Huisman RC, Thali M, McKeating JA, Sodroski J, Goudsmit J, Osterhaus AD
AIDS. 1993
PubMed ID: 7689324
Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro.
Mariniello L, Esposito C, Di Pierro P, Cozzolino A, Pucci P, Porta R
Eur J Biochem. 1993
PubMed ID: 7688299
Identification of a new neutralizing epitope conformationally affected by the attachment of CD4 to gp120.
Kang CY, Hariharan K, Posner MR, Nara P
J Immunol. 1993
PubMed ID: 7686944
Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding.
Thali M, Moore JP, Furman C, Charles M, Ho DD, Robinson J, Sodroski J
J Virol. 1993
PubMed ID: 7685405
CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals.
Mariani R, Skowronski J
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8516299
Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8.
Schilham MW, Fung-Leung WP, Rahemtulla A, Kuendig T, Zhang L, Potter J, Miller RG, Hengartner H, Mak TW
Eur J Immunol. 1993
PubMed ID: 8500525
Effect of amino acid changes in the V1/V2 region of the human immunodeficiency virus type 1 gp120 glycoprotein on subunit association, syncytium formation, and recognition by a neutralizing antibody.
Sullivan N, Thali M, Furman C, Ho DD, Sodroski J
J Virol. 1993
PubMed ID: 8497077
A monoclonal antibody to the CDR-3 region of CD4 inhibits soluble CD4 binding to virions of human immunodeficiency virus type 1.
Moore JP
J Virol. 1993
PubMed ID: 8497074
Crystal structure of domains 3 and 4 of rat CD4: relation to the NH2-terminal domains.
Brady RL, Dodson EJ, Dodson GG, Lange G, Davis SJ, Williams AF, Barclay AN
Science. 1993
PubMed ID: 8493535
Human immunodeficiency virus type 1 envelope gp120 is cleaved after incubation with recombinant soluble CD4.
Werner A, Levy JA
J Virol. 1993
PubMed ID: 8474162
Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.
Davis CB, Killeen N, Crooks ME, Raulet D, Littman DR
Cell. 1993
PubMed ID: 8097431
Patterns of cytokine gene expression by CD4+ T cells from young and old mice.
Hobbs MV, Weigle WO, Noonan DJ, Torbett BE, McEvilly RJ, Koch RJ, Cardenas GJ, Ernst DN
J Immunol. 1993
PubMed ID: 8096853
The short 3'-end region of complementary DNAs as PCR-based polymorphic markers for an expression map of the mouse genome.
Takahashi N, Ko MS
Genomics. 1993
PubMed ID: 8486351
Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.
Killeen N, Sawada S, Littman DR
EMBO J. 1993
PubMed ID: 8467804
The envelope glycoprotein of human immunodeficiency virus type 1 stimulates release of neurotoxins from monocytes.
Giulian D, Wendt E, Vaca K, Noonan CA
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8464887
Human monoclonal antibodies to the V3 loop of HIV-1 gp120 mediate variable and distinct effects on binding and viral neutralization by a human monoclonal antibody to the CD4 binding site.
Cavacini LA, Emes CL, Power J, Buchbinder A, Zolla-Pazner S, Posner MR
J Acquir Immune Defic Syndr. 1993
PubMed ID: 8455141
Structural studies on synthetic peptides from the principal neutralizing domain of HIV-1 gp120 that bind to CD4 and enhance HIV-1 infection.
Dettin M, De Rossi A, Autiero M, Guardiola J, Chieco-Bianchi L, Di Bello C
Biochem Biophys Res Commun. 1993
PubMed ID: 8460995
Secretion of a truncated form of the human immunodeficiency virus type 1 envelope glycoprotein.
Hallenberger S, Tucker SP, Owens RJ, Bernstein HB, Compans RW
Virology. 1993
PubMed ID: 8438588
Calcium ions are required for cell fusion mediated by the CD4-human immunodeficiency virus type 1 envelope glycoprotein interaction.
Dimitrov DS, Broder CC, Berger EA, Blumenthal R
J Virol. 1993
PubMed ID: 8437234
The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4.
Garcia JV, Alfano J, Miller AD
J Virol. 1993
PubMed ID: 8437228
Two mechanisms of soluble CD4 (sCD4)-mediated inhibition of human immunodeficiency virus type 1 (HIV-1) infectivity and their relation to primary HIV-1 isolates with reduced sensitivity to sCD4.
Orloff SL, Kennedy MS, Belperron AA, Maddon PJ, McDougal JS
J Virol. 1993
PubMed ID: 8437224
Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine.
Shilatifard A, Merkle RK, Helland DE, Welles JL, Haseltine WA, Cummings RD
J Virol. 1993
PubMed ID: 8419650
CD4 molecules with a diversity of mutations encompassing the CDR3 region efficiently support human immunodeficiency virus type 1 envelope glycoprotein-mediated cell fusion.
Broder CC, Berger EA
J Virol. 1993
PubMed ID: 8419649
Morphometric analysis of envelope glycoprotein gp120 distribution on HIV-1 virions.
Hart TK, Klinkner AM, Ventre J, Bugelski PJ
J Histochem Cytochem. 1993
PubMed ID: 7678271
Role of CD4 and CD8 in T cell activation and differentiation.
Miceli MC, Parnes JR
Adv Immunol. 1993
PubMed ID: 8512039
Neutralization of HIV-1 by F105, a human monoclonal antibody to the CD4 binding site of gp120.
Posner MR, Cavacini LA, Emes CL, Power J, Byrn R
J Acquir Immune Defic Syndr. 1993
PubMed ID: 8417177
Glycosylation is necessary for the correct folding of human immunodeficiency virus gp120 in CD4 binding.
Li Y, Luo L, Rasool N, Kang CY
J Virol. 1993
PubMed ID: 8416385
Receptor-mediated activation of the viral envelope and viral entry.
Allan JS
AIDS. 1993
PubMed ID: 8363802
Fusion of human immunodeficiency virus-infected cells with uninfected cells.
Lifson JD
Methods Enzymol. 1993
PubMed ID: 8361381
DNA sequence analysis and polymorphism of the mouse CD4 gene.
Wade N, Flaherty L
Immunogenetics. 1993
PubMed ID: 8344730
Human immunodeficiency virus gp120 binding C'C" ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules.
Moebius U, Clayton LK, Abraham S, Diener A, Yunis JJ, Harrison SC, Reinherz EL
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1465431
Stable expression of the human immunodeficiency virus type 1 envelope glycoprotein in transfected L cells.
Bird C, Gleeson PA, Ramsay A, Li P, McCluskey J
AIDS Res Hum Retroviruses. 1992
PubMed ID: 1493050
Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4.
Willey RL, Maldarelli F, Martin MA, Strebel K
J Virol. 1992
PubMed ID: 1433512
Synergistic interaction between ligands binding to the CD4 binding site and V3 domain of human immunodeficiency virus type I gp120.
McKeating JA, Cordell J, Dean CJ, Balfe P
Virology. 1992
PubMed ID: 1280382
Relationship of the human immunodeficiency virus type 1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region.
Wyatt R, Thali M, Tilley S, Pinter A, Posner M, Ho D, Robinson J, Sodroski J
J Virol. 1992
PubMed ID: 1279195
The monoclonal CD4 antibody M-T413 inhibits cellular infection with human immunodeficiency virus after viral attachment to the cell membrane: an approach to postexposure prophylaxis.
Rieber EP, Federle C, Reiter C, Krauss S, Gürtler L, Eberle J, Deinhardt F, Riethmüller G
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1438278
Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells.
Morse HC
J Immunol. 1992
PubMed ID: 1431091
A CD4-derived peptide carrier blocks acute HIV-1 infection in vitro and binds to gp120 in the presence of Walter-Reed stage 1-6 HIV+ sera.
Ghetie V, Wheeler T, Scott D, Uhr JW, Vitetta ES
AIDS Res Hum Retroviruses. 1992
PubMed ID: 1489581
Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6.
Yi T, Gilbert DJ, Jenkins NA, Copeland NG, Ihle JN
Genomics. 1992
PubMed ID: 1427910
Cloning and sequences of primate CD4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency virus.
Fomsgaard A, Hirsch VM, Johnson PR
Eur J Immunol. 1992
PubMed ID: 1425921
CD4 expression is differentially required for deletion of MLS-1a-reactive T cells.
Wallace VA, Rahemtulla A, Timms E, Penninger J, Mak TW
J Exp Med. 1992
PubMed ID: 1402689
Human immunodeficiency virus-infected monocyte-derived macrophages express surface gp120 and fuse with CD4 lymphoid cells in vitro: a possible mechanism of T lymphocyte depletion in vivo.
Crowe SM, Mills J, Elbeik T, Lifson JD, Kosek J, Marshall JA, Engleman EG, McGrath MS
Clin Immunol Immunopathol. 1992
PubMed ID: 1356673
CD4 activation of HIV fusion.
Sattentau QJ
Int J Cell Cloning. 1992
PubMed ID: 1281202
Human immunodeficiency virus type 1 envelope glycoprotein molecules containing membrane fusion-impairing mutations in the V3 region efficiently undergo soluble CD4-stimulated gp120 release.
Berger EA, Sisler JR, Earl PL
J Virol. 1992
PubMed ID: 1527858
Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.
Banda NK, Bernier J, Kurahara DK, Kurrle R, Haigwood N, Sekaly RP, Finkel TH
J Exp Med. 1992
PubMed ID: 1402655
CD4 is expressed on murine pluripotent hematopoietic stem cells.
Wineman JP, Gilmore GL, Gritzmacher C, Torbett BE, Müller-Sieburg CE
Blood. 1992
PubMed ID: 1391941
Effect of human immunodeficiency virus-1 envelope glycoprotein on in vitro hematopoiesis of umbilical cord blood.
Sugiura K, Oyaizu N, Pahwa R, Kalyanaraman VS, Pahwa S
Blood. 1992
PubMed ID: 1520872
Analysis of HIV-induced autoantibodies to cryptic epitopes on human CD4.
Callahan LN, Roderiquez G, Mallinson M, Norcross MA
J Immunol. 1992
PubMed ID: 1381399
Multimeric CD4 binding exhibited by human and simian immunodeficiency virus envelope protein dimers.
Earl PL, Doms RW, Moss B
J Virol. 1992
PubMed ID: 1501294
Lack of correlation between soluble CD4-induced shedding of the human immunodeficiency virus type 1 exterior envelope glycoprotein and subsequent membrane fusion events.
Thali M, Furman C, Helseth E, Repke H, Sodroski J
J Virol. 1992
PubMed ID: 1501286
Studies on the role of the V3 loop in human immunodeficiency virus type 1 envelope glycoprotein function.
Chiou SH, Freed EO, Panganiban AT, Kenealy WR
AIDS Res Hum Retroviruses. 1992
PubMed ID: 1457207
LFA-1 adhesion molecules are not involved in the early stages of HIV-1 env-mediated cell membrane fusion.
Golding H, Dimitrov DS, Blumenthal R
AIDS Res Hum Retroviruses. 1992
PubMed ID: 1457205
Amino acid residues of the human immunodeficiency virus type I gp120 critical for the binding of rat and human neutralizing antibodies that block the gp120-sCD4 interaction.
McKeating JA, Thali M, Furman C, Karwowska S, Gorny MK, Cordell J, Zolla-Pazner S, Sodroski J, Weiss RA
Virology. 1992
PubMed ID: 1382339
Discontinuous, conserved neutralization epitopes overlapping the CD4-binding region of human immunodeficiency virus type 1 gp120 envelope glycoprotein.
Thali M, Furman C, Ho DD, Robinson J, Tilley S, Pinter A, Sodroski J
J Virol. 1992
PubMed ID: 1380099
Effects of CD4 synthetic peptides on HIV type I envelope glycoprotein function.
Repke H, Gabuzda D, Palù G, Emmrich F, Sodroski J
J Immunol. 1992
PubMed ID: 1354681
Striking identity between HIV-1 envelope glycoprotein gp120 and its CD4 receptor.
Zagury JF, Cantalloube H, Bernard J, Mornon JP, Bizzini B, Zagury D
Lancet. 1992
PubMed ID: 1354808
Conjugation of soluble CD4 without loss of biological activity via a novel carbohydrate-directed cross-linking reagent.
Chamow SM, Kogan TP, Peers DH, Hastings RC, Byrn RA, Ashkenazi A
J Biol Chem. 1992
PubMed ID: 1639820
The human immunodeficiency virus gp120 binding site on CD4: delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure.
Moebius U, Clayton LK, Abraham S, Harrison SC, Reinherz EL
J Exp Med. 1992
PubMed ID: 1500858
Are sense-antisense peptide interactions between HIV-1 (gp120), CD4, and the proto oncogene product p56lck important?
Brown R, Meldrum C, Cousins S
Med Hypotheses. 1992
PubMed ID: 1491632
A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells.
Moore JP, Sattentau QJ, Klasse PJ, Burkly LC
J Virol. 1992
PubMed ID: 1378510
Identification of envelope V3 loop as the major determinant of CD4 neutralization sensitivity of HIV-1.
Hwang SS, Boyle TJ, Lyerly HK, Cullen BR
Science. 1992
PubMed ID: 1636088
Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor.
Crise B, Rose JK
J Biol Chem. 1992
PubMed ID: 1618861
Antibody and HIV-1 gp120 recognition of CD4 undermines the concept of mimicry between antibodies and receptors.
Davis SJ, Schockmel GA, Somoza C, Buck DW, Healey DG, Rieber EP, Reiter C, Williams AF
Nature. 1992
PubMed ID: 1614536
Mouse macrophages contain a truncated CD4 transcript.
Moore SC, Anderson SJ, Walker WS
J Leukoc Biol. 1992
PubMed ID: 1640169
Changes in both gp120 and gp41 can account for increased growth potential and expanded host range of human immunodeficiency virus type 1.
Fujita K, Silver J, Peden K
J Virol. 1992
PubMed ID: 1602552
Internalization of HIV glycoprotein gp120 is associated with down-modulation of membrane CD4 and p56lck together with impairment of T cell activation.
Cefai D, Ferrer M, Serpente N, Idziorek T, Dautry-Varsat A, Debre P, Bismuth G
J Immunol. 1992
PubMed ID: 1535086
Design and synthesis of a CD4 beta-turn mimetic that inhibits human immunodeficiency virus envelope glycoprotein gp120 binding and infection of human lymphocytes.
Chen S, Chrusciel RA, Nakanishi H, Raktabutr A, Johnson ME, Sato A, Weiner D, Hoxie J, Saragovi HU, Greene MI
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1352879
Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor. Genomic organization, expression, and chromosomal localization.
Ludwig T, Rüther U, Metzger R, Copeland NG, Jenkins NA, Lobel P, Hoflack B
J Biol Chem. 1992
PubMed ID: 1376319
HIV interactions with CD4: a continuum of conformations and consequences.
Eiden LE, Lifson JD
Immunol Today. 1992
PubMed ID: 1627247
Localized conformational changes in the N-terminal domain of CD4 identified in competitive binding assay of monoclonal antibodies and HIV-1 envelope glycoprotein.
Walker L, Wilks D, O'Brien J, Habeshaw J, Dalgleish A
AIDS Res Hum Retroviruses. 1992
PubMed ID: 1503822
Study of viral replication in HIV-1-infected CEM T-cell subclones which are reduced in their ability to form syncytia.
Gruber MF, Hewlett IK, Simms T, Vujcic L, Manischewitz J, Golding H
AIDS Res Hum Retroviruses. 1992
PubMed ID: 1380260
Recombinant glycoprotein 120 of human immunodeficiency virus is a potent interferon inducer.
Capobianchi MR, Ankel H, Ameglio F, Paganelli R, Pizzoli PM, Dianzani F
AIDS Res Hum Retroviruses. 1992
PubMed ID: 1381203
Functional activity of an HIV-1 neutralizing IgG human monoclonal antibody: ADCC and complement-mediated lysis.
Posner MR, Elboim HS, Cannon T, Cavacini L, Hideshima T
AIDS Res Hum Retroviruses. 1992
PubMed ID: 1381201
CD4 epitope masking by gp120/anti-gp120 antibody complexes. A potential mechanism for CD4+ cell function down-regulation in AIDS patients.
Amadori A, De Silvestro G, Zamarchi R, Veronese ML, Mazza MR, Schiavo G, Panozzo M, De Rossi A, Ometto L, Mous J
J Immunol. 1992
PubMed ID: 1374095
Synthetic peptides and anti-peptide antibodies as probes to study interdomain interactions involved in virus assembly: the envelope of the human immunodeficiency virus (HIV-1).
Neurath AR, Strick N, Jiang S
Virology. 1992
PubMed ID: 1373549
Mapping genetic determinants for human immunodeficiency virus type 1 resistance to soluble CD4.
O'Brien WA, Chen IS, Ho DD, Daar ES
J Virol. 1992
PubMed ID: 1373203
Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail.
Seong RH, Chamberlain JW, Parnes JR
Nature. 1992
PubMed ID: 1533274
The V3 region of the envelope glycoprotein of human immunodeficiency virus type 1 binds sulfated polysaccharides and CD4-derived synthetic peptides.
Batinić D, Robey FA
J Biol Chem. 1992
PubMed ID: 1551875
Thermodynamic and kinetic analysis of sCD4 binding to HIV-1 virions and of gp120 dissociation.
Moore JP, Klasse PJ
AIDS Res Hum Retroviruses. 1992
PubMed ID: 1599754
Synthetic peptides from a conserved region of gp120 induce broadly reactive anti-HIV responses.
Morrow WJ, Williams WM, Whalley AS, Ryskamp T, Newman R, Kang CY, Chamat S, Köhler H, Kieber-Emmons T
Immunology. 1992
PubMed ID: 1592430
Human trophoblast cells express CD4 and are permissive for productive infection with HIV-1.
David FJ, Autran B, Tran HC, Menu E, Raphael M, Debre P, Hsi BL, Wegman TG, Barre-Sinoussi F, Chaouat G
Clin Exp Immunol. 1992
PubMed ID: 1563094
Target cell-specific determinants of membrane fusion within the human immunodeficiency virus type 1 gp120 third variable region and gp41 amino terminus.
Bergeron L, Sullivan N, Sodroski J
J Virol. 1992
PubMed ID: 1548769
Human immunodeficiency virus type 1 glycoprotein precursor retains a CD4-p56lck complex in the endoplasmic reticulum.
Crise B, Rose JK
J Virol. 1992
PubMed ID: 1548763
Mutations in the principal neutralization determinant of human immunodeficiency virus type 1 affect syncytium formation, virus infectivity, growth kinetics, and neutralization.
Grimaila RJ, Fuller BA, Rennert PD, Nelson MB, Hammarskjöld ML, Potts B, Murray M, Putney SD, Gray G
J Virol. 1992
PubMed ID: 1548744
V3 loop region of the HIV-1 gp120 envelope protein is essential for virus infectivity.
Ivanoff LA, Dubay JW, Morris JF, Roberts SJ, Gutshall L, Sternberg EJ, Hunter E, Matthews TJ, Petteway SR
Virology. 1992
PubMed ID: 1546447
Generation of mutant mice lacking surface expression of CD4 or CD8 by gene targeting.
Mak TW, Rahemtulla A, Schilham M, Koh DR, Fung-Leung WP
J Autoimmun. 1992
PubMed ID: 1503636
Synergistic neutralization of HIV-1 by human monoclonal antibodies against the V3 loop and the CD4-binding site of gp120.
Tilley SA, Honnen WJ, Racho ME, Chou TC, Pinter A
AIDS Res Hum Retroviruses. 1992
PubMed ID: 1376135
Monoclonal antibodies to the C4 region of human immunodeficiency virus type 1 gp120: use in topological analysis of a CD4 binding site.
McKeating JA, Moore JP, Ferguson M, Marsden HS, Graham S, Almond JW, Evans DJ, Weiss RA
AIDS Res Hum Retroviruses. 1992
PubMed ID: 1376134
Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5.
Beyers AD, Spruyt LL, Williams AF
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1372996
Nonrandom distribution of gp120 N-linked glycosylation sites important for infectivity of human immunodeficiency virus type 1.
Lee WR, Syu WJ, Du B, Matsuda M, Tan S, Wolf A, Essex M, Lee TH
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1549584
Kinetics of the HIV-CD4 interactions and virus-cell fusion.
Klasse PJ, Moore JP
AIDS. 1992
PubMed ID: 1567578
Correlation between kinetics of soluble CD4 interactions with HIV-1-Env-expressing cells and inhibition of syncytia formation: implications for mechanisms of cell fusion and therapy for AIDS.
Dimitrov DS, Hillman K, Manischewitz J, Blumenthal R, Golding H
AIDS. 1992
PubMed ID: 1348943
Inhibition of T cell antigen receptor-dependent phosphorylation of CD4 in human immunodeficiency virus type 1 infected cells.
Gaulton GN, Brass LF, Kozbor D, Pletcher CH, Hoxie JA
J Biol Chem. 1992
PubMed ID: 1310988
The effect of p56lck, a lymphocyte specific protein tyrosine kinase, on the syncytium formation induced by human immunodeficiency virus envelope glycoprotein.
Yoshida H, Koga Y, Moroi Y, Kimura G, Nomoto K
Int Immunol. 1992
PubMed ID: 1622897
Simple assay to screen for inhibitors of interaction between the human immunodeficiency virus envelope glycoprotein and its cellular receptor, CD4.
Chams V, Idziorek T, Maddon PJ, Klatzmann D
Antimicrob Agents Chemother. 1992
PubMed ID: 1605591
Truncated variants of gp120 bind CD4 with high affinity and suggest a minimum CD4 binding region.
Pollard SR, Rosa MD, Rosa JJ, Wiley DC
EMBO J. 1992
PubMed ID: 1537337
Interaction of human immunodeficiency virus glycoprotein 160 with CD4 in Jurkat cells increases p56lck autophosphorylation and kinase activity.
Soula M, Fagard R, Fischer S
Int Immunol. 1992
PubMed ID: 1535787
Cell-to-cell spread of HIV-1 occurs within minutes and may not involve the participation of virus particles.
Sato H, Orenstein J, Dimitrov D, Martin M
Virology. 1992
PubMed ID: 1370739
Identification and characterization of a neutralization site within the second variable region of human immunodeficiency virus type 1 gp120.
Fung MS, Sun CR, Gordon WL, Liou RS, Chang TW, Sun WN, Daar ES, Ho DD
J Virol. 1992
PubMed ID: 1370558
Expression of the signal transducing regions of CD4-like and lck genes in murine egg.
Mori T, Gou MW, Yoshida H, Saito S, Mori E
Biochem Biophys Res Commun. 1992
PubMed ID: 1370884
Contribution of disulfide bonds in the carboxyl terminus of the human immunodeficiency virus type I gp120 glycoprotein to CD4 binding.
Lekutis C, Olshevsky U, Furman C, Thali M, Sodroski J
J Acquir Immune Defic Syndr. 1992
PubMed ID: 1738091
Lectin-carbohydrate interactions and infectivity of human immunodeficiency virus type 1 (HIV-1).
Gattegno L, Ramdani A, Jouault T, Saffar L, Gluckman JC
AIDS Res Hum Retroviruses. 1992
PubMed ID: 1736938
Contribution of charged amino acids in the CDR2 region of CD4 to HIV-1 gp120 binding.
Choe HR, Sodroski J
J Acquir Immune Defic Syndr. 1992
PubMed ID: 1732513
Construction of a binding site for human immunodeficiency virus type 1 gp120 in rat CD4.
Schockmel GA, Somoza C, Davis SJ, Williams AF, Healey D
J Exp Med. 1992
PubMed ID: 1730924
Analysis of mutations in the V3 domain of gp160 that affect fusion and infectivity.
Page KA, Stearns SM, Littman DR
J Virol. 1992
PubMed ID: 1727497
Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates.
Moore JP, McKeating JA, Huang YX, Ashkenazi A, Ho DD
J Virol. 1992
PubMed ID: 1727487
Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes.
Willey RL, Maldarelli F, Martin MA, Strebel K
J Virol. 1992
PubMed ID: 1727486
Kinetics of soluble CD4 binding to cells expressing human immunodeficiency virus type 1 envelope glycoprotein.
Dimitrov DS, Hillman K, Manischewitz J, Blumenthal R, Golding H
J Virol. 1992
PubMed ID: 1727475
Cooperativity of neutralizing antibodies directed against the V3 and CD4 binding regions of the human immunodeficiency virus gp120 envelope glycoprotein.
Thali M, Furman C, Wahren B, Posner M, Ho DD, Robinson J, Sodroski J
J Acquir Immune Defic Syndr. 1992
PubMed ID: 1588493
Development and characterization of a whole-cell radioligand binding assay for [125I]gp120 of HIV-1.
To LP, Balasubramanian V, Charlton ME, Francis TA, Doyle C, Sweetnam PM
J Immunoassay. 1992
PubMed ID: 1569213
Downregulation of cell surface CD4 by nef.
Garcia JV, Miller AD
Res Virol. 1992
PubMed ID: 1565858
Generation and characterization of a human monoclonal antibody that neutralizes diverse HIV-1 isolates in vitro.
Lake DF, Kawamura T, Tomiyama T, Robinson WE, Matsumoto Y, Masuho Y, Hersh EM
AIDS. 1992
PubMed ID: 1543562
Interactions of CD4+ plasma membrane vesicles with HIV-1 and HIV-1 envelope glycoprotein-expressing cells.
Puri A, Dimitrov DS, Golding H, Blumenthal R
J Acquir Immune Defic Syndr. 1992
PubMed ID: 1512692
A method to analyze the interaction between gp120 of human immunodeficiency virus and CD4.
Lanza P, Washington LC, Zanetti M
Viral Immunol. 1992
PubMed ID: 1472279
Immunological characteristics of the putative CD4-binding site of the HIV-1 envelope protein.
Kieber-Emmons T, Krowka JF, Boyer J, Ugen KE, Williams WV, Morrow WJ, Weiner DB
Pathobiology. 1992
PubMed ID: 1388715
Localization of mouse parathyroid hormone-like peptide gene (Pthlh) to distal chromosome 6 using interspecific backcross mice and in situ hybridization.
Seldin MF, Mattei MG, Hendy GN
Cytogenet Cell Genet. 1992
PubMed ID: 1354597
CD4-binding regions of human immunodeficiency virus envelope glycoprotein gp120 defined by proteolytic digestion.
Pollard SR, Meier W, Chow P, Rosa JJ, Wiley DC
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1763044
Interaction of seminal plasma proteins with cell surface antigens: presence of a CD4-binding glycoprotein in human seminal plasma.
Autiero M, Abrescia P, Guardiola J
Exp Cell Res. 1991
PubMed ID: 1959561
The ability of suramin to block CD4-gp120 binding is reversed in the presence of albumin.
Yao XJ, Wainberg MA, Richard M, Pollak M
Antimicrob Agents Chemother. 1991
PubMed ID: 1810199
Binding to CD4 of synthetic peptides patterned on the principal neutralizing domain of the HIV-1 envelope protein.
Autiero M, Abrescia P, Dettin M, Di Bello C, Guardiola J
Virology. 1991
PubMed ID: 1720590
Analysis of synergism/antagonism between HIV-1 antibody-positive human sera and soluble CD4 in blocking HIV-1 binding and infectivity.
Kennedy MS, Orloff S, Ibegbu CC, Odell CD, Maddon PJ, McDougal JS
AIDS Res Hum Retroviruses. 1991
PubMed ID: 1687500
Physical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells.
Mittler RS, Rankin BM, Kiener PA
J Immunol. 1991
PubMed ID: 1834739
A single amino acid substitution in a common African allele of the CD4 molecule ablates binding of the monoclonal antibody, OKT4.
Lederman S, DeMartino JA, Daugherty BL, Foeldvari I, Yellin MJ, Cleary AM, Berkowitz N, Lowy I, Braunstein NS, Mark GE
Mol Immunol. 1991
PubMed ID: 1961196
Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene.
Sawada S, Littman DR
Mol Cell Biol. 1991
PubMed ID: 1922061
The HIV-1 gp120 envelope protein has the intrinsic capacity to stimulate monokine secretion.
Clouse KA, Cosentino LM, Weih KA, Pyle SW, Robbins PB, Hochstein HD, Natarajan V, Farrar WL
J Immunol. 1991
PubMed ID: 1918997
Antibody-dependent cell-mediated cytotoxicity directed by a human monoclonal antibody reactive with gp120 of HIV-1.
Koup RA, Robinson JE, Nguyen QV, Pikora CA, Blais B, Roskey A, Panicali D, Sullivan JL
AIDS. 1991
PubMed ID: 1722676
Characterization of a discontinuous human immunodeficiency virus type 1 gp120 epitope recognized by a broadly reactive neutralizing human monoclonal antibody.
Thali M, Olshevsky U, Furman C, Gabuzda D, Posner M, Sodroski J
J Virol. 1991
PubMed ID: 1717717
N-glycosylation of HIV-gp120 may constrain recognition by T lymphocytes.
Botarelli P, Houlden BA, Haigwood NL, Servis C, Montagna D, Abrignani S
J Immunol. 1991
PubMed ID: 1717587
Inhibition of human immunodeficiency virus infection in monocytes by monoclonal antibodies against leukocyte adhesion molecules.
Kalter DC, Gendelman HE, Meltzer MS
Immunol Lett. 1991
PubMed ID: 1757107
Initial stages of HIV-1 envelope glycoprotein-mediated cell fusion monitored by a new assay based on redistribution of fluorescent dyes.
Dimitrov DS, Golding H, Blumenthal R
AIDS Res Hum Retroviruses. 1991
PubMed ID: 1742075
N-terminal residues 105-117 of HIV-1 gp120 are not involved in CD4 binding.
el Ahmar W, Poumbourios P, McPhee DA, Kemp BE
AIDS Res Hum Retroviruses. 1991
PubMed ID: 1720631
Identification of conserved residues in the human immunodeficiency virus type 1 principal neutralizing determinant that are involved in fusion.
Freed EO, Risser R
AIDS Res Hum Retroviruses. 1991
PubMed ID: 1720627
Stimulation of glycoprotein gp120 dissociation from the envelope glycoprotein complex of human immunodeficiency virus type 1 by soluble CD4 and CD4 peptide derivatives: implications for the role of the complementarity-determining region 3-like region in m
Berger EA, Lifson JD, Eiden LE
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1896455
Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4.
Rahemtulla A, Fung-Leung WP, Schilham MW, Kündig TM, Sambhara SR, Narendran A, Arabian A, Wakeham A, Paige CJ, Zinkernagel RM
Nature. 1991
PubMed ID: 1832488
Mutational analysis of the interaction between CD4 and class II MHC: class II antigens contact CD4 on a surface opposite the gp120-binding site.
Fleury S, Lamarre D, Meloche S, Ryu SE, Cantin C, Hendrickson WA, Sekaly RP
Cell. 1991
PubMed ID: 1889086
Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity.
Thali M, Olshevsky U, Furman C, Gabuzda D, Li J, Sodroski J
J Virol. 1991
PubMed ID: 1870209
Recombinant CD4-selected human immunodeficiency virus type 1 variants with reduced gp120 affinity for CD4 and increased cell fusion capacity.
McKeating J, Balfe P, Clapham P, Weiss RA
J Virol. 1991
PubMed ID: 1870202
Resistance of primary isolates of human immunodeficiency virus type 1 to soluble CD4 is independent of CD4-rgp120 binding affinity.
Ashkenazi A, Smith DH, Marsters SA, Riddle L, Gregory TJ, Ho DD, Capon DJ
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1871120
CD4-gp120 interactions.
McDougal JS, Klatzmann DR, Maddon PJ
Curr Opin Immunol. 1991
PubMed ID: 1721822
Mutations in the D strand of the human CD4 V1 domain affect CD4 interactions with the human immunodeficiency virus envelope glycoprotein gp120 and HLA class II antigens similarly.
Piatier-Tonneau D, Gastinel LN, Moussy G, Bénichou B, Amblard F, Vaigot P, Auffray C
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1713692
Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.
Sattentau QJ, Moore JP
J Exp Med. 1991
PubMed ID: 1713252
Effect of a glucosidase inhibitor on the bioactivity and immunoreactivity of human immunodeficiency virus type 1 envelope glycoprotein.
Fenouillet E, Gluckman JC
J Gen Virol. 1991
PubMed ID: 1678778
Evidence for non-V3-specific neutralizing antibodies that interfere with gp120/CD4 binding in human immunodeficiency virus 1-infected humans.
Kang CY, Nara P, Chamat S, Caralli V, Ryskamp T, Haigwood N, Newman R, Köhler H
Proc Natl Acad Sci U S A. 1991
PubMed ID: 2068099
Inhibition of CD4+ T cell activation and adhesion by peptides derived from the gp160.
Corado J, Mazerolles F, Le Deist F, Barbat C, Kaczorek M, Fischer A
J Immunol. 1991
PubMed ID: 1677023
CD4 peptide-protein conjugates, but not recombinant human CD4, bind to recombinant gp120 from the human immunodeficiency virus in the presence of serum from AIDS patients.
Ghetie V, Slaughter C, Wheeler HT, Uhr JW, Vitetta ES
Proc Natl Acad Sci U S A. 1991
PubMed ID: 2062847
A human monoclonal antibody against the CD4-binding site of HIV1 gp120 exhibits potent, broadly neutralizing activity.
Tilley SA, Honnen WJ, Racho ME, Hilgartner M, Pinter A
Res Virol. 1991
PubMed ID: 1724568
CD4+ lipid bilayers. A model for human immunodeficiency virus type 1 coat protein binding.
Tosteson MT, Tosi PF, Nicolau C, Tosteson DC
J Biol Chem. 1991
PubMed ID: 1711033
Effect of human immunodeficiency virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 in human T lymphocytes.
Juszczak RJ, Turchin H, Truneh A, Culp J, Kassis S
J Biol Chem. 1991
PubMed ID: 2040625
An IgG human monoclonal antibody that reacts with HIV-1/GP120, inhibits virus binding to cells, and neutralizes infection.
Posner MR, Hideshima T, Cannon T, Mukherjee M, Mayer KH, Byrn RA
J Immunol. 1991
PubMed ID: 1710248
Effects of mutations in glycosylation sites and disulphide bonds on processing, CD4-binding and fusion activity of human immunodeficiency virus envelope glycoproteins.
Bolmstedt A, Hemming A, Flodby P, Berntsson P, Travis B, Lin JP, Ledbetter J, Tsu T, Wigzell H, Hu SL
J Gen Virol. 1991
PubMed ID: 2045792
Synthetic peptides allow discrimination of structural features of CD4(81-92) important for HIV-1 infection versus HIV-1-induced syncytium formation.
Lifson JD, Rausch DM, Kalyanaraman VS, Hwang KM, Eiden LE
AIDS Res Hum Retroviruses. 1991
PubMed ID: 1931230
Posttranslational modifications within the HIV-1 envelope glycoprotein which restrict virus assembly and CD4-dependent infection.
Haggerty S, Dempsey MP, Bukrinsky MI, Guo L, Stevenson M
AIDS Res Hum Retroviruses. 1991
PubMed ID: 1931229
CD4-mediated stimulation of human eosinophils: lymphocyte chemoattractant factor and other CD4-binding ligands elicit eosinophil migration.
Rand TH, Cruikshank WW, Center DM, Weller PF
J Exp Med. 1991
PubMed ID: 1851800
Human immunodeficiency virus infection and syncytium formation in HeLa cells expressing glycophospholipid-anchored CD4.
Kost TA, Kessler JA, Patel IR, Gray JG, Overton LK, Carter SG
J Virol. 1991
PubMed ID: 1709701
Blocking of human immunodeficiency virus infection depends on cell density and viral stock age.
Layne SP, Merges MJ, Spouge JL, Dembo M, Nara PL
J Virol. 1991
PubMed ID: 1674549
Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor.
Goodwin RG, Anderson D, Jerzy R, Davis T, Brannan CI, Copeland NG, Jenkins NA, Smith CA
Mol Cell Biol. 1991
PubMed ID: 1645445
Lateral diffusion of CD4 on the surface of a human neoplastic T-cell line probed with a fluorescent derivative of the envelope glycoprotein (gp120) of human immunodeficiency virus type 1 (HIV-1).
Pal R, Nair BC, Hoke GM, Sarngadharan MG, Edidin M
J Cell Physiol. 1991
PubMed ID: 2040664
The interaction of CD4 with HIV-1 gp120.
Silberman SL, Goldman SJ, Mitchell DB, Tong AT, Rosenstein Y, Diamond DC, Finberg RW, Schreiber SL, Burakoff SJ
Semin Immunol. 1991
PubMed ID: 1888898
Deamidation of soluble CD4 at asparagine-52 results in reduced binding capacity for the HIV-1 envelope glycoprotein gp120.
Teshima G, Porter J, Yim K, Ling V, Guzzetta A
Biochemistry. 1991
PubMed ID: 2018763
Serine phosphorylation-independent downregulation of cell-surface CD4 by nef.
Garcia JV, Miller AD
Nature. 1991
PubMed ID: 2014052
Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activity.
Miceli MC, von Hoegen P, Parnes JR
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1901411
A region in domain 1 of CD4 distinct from the primary gp120 binding site is involved in HIV infection and virus-mediated fusion.
Truneh A, Buck D, Cassatt DR, Juszczak R, Kassis S, Ryu SE, Healey D, Sweet R, Sattentau Q
J Biol Chem. 1991
PubMed ID: 1706342
Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.
Hart TK, Kirsh R, Ellens H, Sweet RW, Lambert DM, Petteway SR, Leary J, Bugelski PJ
Proc Natl Acad Sci U S A. 1991
PubMed ID: 2006155
Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4.
Moore JP, McKeating JA, Norton WA, Sattentau QJ
J Virol. 1991
PubMed ID: 1995942
Infection of monocytic cells by HIV1: combined role of FcR and CD4.
Jouault T, Chapuis F, Bahraoui E, Gluckman JC
Res Virol. 1991
PubMed ID: 1832782
Binding of recombinant HIV coat protein gp120 to human monocytes.
Finbloom DS, Hoover DL, Meltzer MS
J Immunol. 1991
PubMed ID: 1991970
Humans with OKT4-epitope deficiency have a single nucleotide base change in the CD4 gene, resulting in substitution of TRP240 for ARG240.
Hodge TW, Sasso DR, McDougal JS
Hum Immunol. 1991
PubMed ID: 1708753
Infection of brain microglial cells by human immunodeficiency virus type 1 is CD4 dependent.
Jordan CA, Watkins BA, Kufta C, Dubois-Dalcq M
J Virol. 1991
PubMed ID: 1702842
Envelope glycoproteins from biologically diverse isolates of immunodeficiency viruses have widely different affinities for CD4.
Ivey-Hoyle M, Culp JS, Chaikin MA, Hellmig BD, Matthews TJ, Sweet RW, Rosenberg M
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1899141
Diminution of CD4 surface protein but not CD4 messenger RNA levels in monocytic cells infected by HIV-1.
Geleziunas R, Bour S, Boulerice F, Hiscott J, Wainberg MA
AIDS. 1991
PubMed ID: 2059359
The V3 loops of the HIV-1 and HIV-2 surface glycoproteins contain proteolytic cleavage sites: a possible function in viral fusion?
Clements GJ, Price-Jones MJ, Stephens PE, Sutton C, Schulz TF, Clapham PR, McKeating JA, McClure MO, Thomson S, Marsh M
AIDS Res Hum Retroviruses. 1991
PubMed ID: 2015114
Binding of recombinant HIV-1 and HIV-2 SU glycoproteins to sCD4.
Moore JP, Morikawa Y, Jones IM
J Acquir Immune Defic Syndr. 1991
PubMed ID: 2007979
Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.
Mitchell PJ, Timmons PM, Hébert JM, Rigby PW, Tjian R
Genes Dev. 1991
PubMed ID: 1989904
Biological and immunological properties of human immunodeficiency virus type 1 envelope glycoprotein: analysis of proteins with truncations and deletions expressed by recombinant vaccinia viruses.
Earl PL, Koenig S, Moss B
J Virol. 1991
PubMed ID: 1985202
Identification of the principal neutralizing determinant of human immunodeficiency virus type 1 as a fusion domain.
Freed EO, Myers DJ, Risser R
J Virol. 1991
PubMed ID: 1985197
Identification of membrane anchorage domains of the HIV-1 gp160 envelope glycoprotein precursor.
Gabuzda D, Olshevsky U, Bertani P, Haseltine WA, Sodroski J
J Acquir Immune Defic Syndr. 1991
PubMed ID: 1984054
Characterization of autoantibodies to the CD4 molecule in human immunodeficiency virus infection.
Sekigawa I, Groopmen JE, Allan JD, Ikeuchi K, Biberfield G, Takatsuki K, Byrn RA
Clin Immunol Immunopathol. 1991
PubMed ID: 1983967
The CD4-gp120 interaction and AIDS pathogenesis.
Capon DJ, Ward RH
Annu Rev Immunol. 1991
PubMed ID: 1910691
The role of the V3 loop of gp120 in HIV infection.
Moore JP, Nara PL
AIDS. 1991
PubMed ID: 1845049
Additional microsatellite markers for mouse genome mapping.
Hearne CM, McAleer MA, Love JM, Aitman TJ, Cornall RJ, Ghosh S, Knight AM, Prins JB, Todd JA
Mamm Genome. 1991
PubMed ID: 1794058
Phosphorothioate oligodeoxycytidine interferes with binding of HIV-1 gp120 to CD4.
Stein CA, Neckers LM, Nair BC, Mumbauer S, Hoke G, Pal R
J Acquir Immune Defic Syndr. 1991
PubMed ID: 1711118
Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody.
Ho DD, McKeating JA, Li XL, Moudgil T, Daar ES, Sun NC, Robinson JE
J Virol. 1991
PubMed ID: 1702163
Mechanism of HIV-1 entry into CD4+ T cells.
Stein BS, Engleman EG
Adv Exp Med Biol. 1991
PubMed ID: 1685857
Evidence by peptide mapping that the region CD4(81-92) is involved in gp120/CD4 interaction leading to HIV infection and HIV-induced syncytium formation.
Kalyanaraman VS, Rausch DM, Osborne J, Padgett M, Hwang KM, Lifson JD, Eiden LE
J Immunol. 1990
PubMed ID: 1701782
Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding.
Olshevsky U, Helseth E, Furman C, Li J, Haseltine W, Sodroski J
J Virol. 1990
PubMed ID: 2243375
Mutation of conserved N-glycosylation sites around the CD4-binding site of human immunodeficiency virus type 1 GP120 affects viral infectivity.
Dirckx L, Lindemann D, Ette R, Manzoni C, Moritz D, Mous J
Virus Res. 1990
PubMed ID: 2082620
Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.
Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G
J Clin Invest. 1990
PubMed ID: 1979339
Glycosylation governs the binding of antipeptide antibodies to regions of hypervariable amino acid sequence within recombinant gp120 of human immunodeficiency virus type 1.
Davis D, Stephens DM, Willers C, Lachmann PJ
J Gen Virol. 1990
PubMed ID: 1703212
Crystal structure of an HIV-binding recombinant fragment of human CD4.
Ryu SE, Kwong PD, Truneh A, Porter TG, Arthos J, Rosenberg M, Dai XP, Xuong NH, Axel R, Sweet RW
Nature. 1990
PubMed ID: 2247146
Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains.
Wang JH, Yan YW, Garrett TP, Liu JH, Rodgers DW, Garlick RL, Tarr GE, Husain Y, Reinherz EL, Harrison SC
Nature. 1990
PubMed ID: 1701030
CD4-affinity purification of recombinant and native HIV gp120 and comparison of the affinity constants for the receptor.
Moritz D, Dirckx L, Mous J, Schneider J
FEBS Lett. 1990
PubMed ID: 2261984
Dissociation of gp120 from HIV-1 virions induced by soluble CD4.
Moore JP, McKeating JA, Weiss RA, Sattentau QJ
Science. 1990
PubMed ID: 2251501
CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor.
Crise B, Buonocore L, Rose JK
J Virol. 1990
PubMed ID: 2214026
A bioassay for HIV-1 based on Env-CD4 interaction.
Ciminale V, Felber BK, Campbell M, Pavlakis GN
AIDS Res Hum Retroviruses. 1990
PubMed ID: 2078409
Enhancement of soluble CD4-mediated HIV neutralization and gp 120 binding by CD4 autoantibodies and monoclonal antibodies.
Moore JP, Sattentau QJ, Clapham PR
AIDS Res Hum Retroviruses. 1990
PubMed ID: 2078408
Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules.
Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ
Proc Natl Acad Sci U S A. 1990
PubMed ID: 1978941
Enzymatic cleavage of a CD4 immunoadhesin generates crystallizable, biologically active Fd-like fragments.
Chamow SM, Peers DH, Byrn RA, Mulkerrin MG, Harris RJ, Wang WC, Bjorkman PJ, Capon DJ, Ashkenazi A
Biochemistry. 1990
PubMed ID: 2125484
Antibody raised against soluble CD4-rgp120 complex recognizes the CD4 moiety and blocks membrane fusion without inhibiting CD4-gp120 binding.
Celada F, Cambiaggi C, Maccari J, Burastero S, Gregory T, Patzer E, Porter J, McDanal C, Matthews T
J Exp Med. 1990
PubMed ID: 2212945
Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site.
Luo KX, Sefton BM
Mol Cell Biol. 1990
PubMed ID: 2118992
Temporal expression of HIV-1 envelope proteins in baculovirus-infected insect cells: implications for glycosylation and CD4 binding.
Murphy CI, Lennick M, Lehar SM, Beltz GA, Young E
Genet Anal Tech Appl. 1990
PubMed ID: 2076345
Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding.
Healey D, Dianda L, Moore JP, McDougal JS, Moore MJ, Estess P, Buck D, Kwong PD, Beverley PC, Sattentau QJ
J Exp Med. 1990
PubMed ID: 1698911
Mapping the CD4 binding site for human immunodeficiency virus by alanine-scanning mutagenesis.
Ashkenazi A, Presta LG, Marsters SA, Camerato TR, Rosenthal KA, Fendly BM, Capon DJ
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2402498
AIDS and glycosylation.
Feizi T, Larkin M
Glycobiology. 1990
PubMed ID: 2136376
Polyionic compounds selectively alter availability of CD4 receptors for HIV coat protein rgp120.
Weaver JL, Gergely P, Pine PS, Patzer E, Aszalos A
AIDS Res Hum Retroviruses. 1990
PubMed ID: 1979910
Full-length recombinant CD4 and recombinant gp120 inhibit fusion between HIV infected macrophages and uninfected CD4-expressing T-lymphoblastoid cells.
Crowe SM, Mills J, Kirihara J, Boothman J, Marshall JA, McGrath MS
AIDS Res Hum Retroviruses. 1990
PubMed ID: 1977427
Prevention of HIV-1 infection and preservation of CD4 function by the binding of CPFs to gp120.
Finberg RW, Diamond DC, Mitchell DB, Rosenstein Y, Soman G, Norman TC, Schreiber SL, Burakoff SJ
Science. 1990
PubMed ID: 2115689
HIV requires multiple gp120 molecules for CD4-mediated infection.
Layne SP, Merges MJ, Dembo M, Spouge JL, Nara PL
Nature. 1990
PubMed ID: 2374593
HIV-1 envelope protein gp120 expression by secretion in E. coli: assessment of CD4 binding and use in epitope mapping.
Morikawa Y, Moore JP, Jones IM
J Virol Methods. 1990
PubMed ID: 1698804
Association of antibodies blocking HIV-1 gp 160-sCD4 attachment with virus neutralizing activity in human sera.
Back NK, Thiriart C, Delers A, Ramautarsing C, Bruck C, Goudsmit J
J Med Virol. 1990
PubMed ID: 1697332
Human CD4 binds immunoglobulins.
Lenert P, Kroon D, Spiegelberg H, Golub ES, Zanetti M
Science. 1990
PubMed ID: 2363051
High level expression in Chinese hamster ovary cells of soluble forms of CD4 T lymphocyte glycoprotein including glycosylation variants.
Davis SJ, Ward HA, Puklavec MJ, Willis AC, Williams AF, Barclay AN
J Biol Chem. 1990
PubMed ID: 2113054
Prevention of HIV-1 glycoprotein transport by soluble CD4 retained in the endoplasmic reticulum.
Buonocore L, Rose JK
Nature. 1990
PubMed ID: 2190096
Expression of HIV-1 gp120 and human soluble CD4 by recombinant baculoviruses and their interaction in vitro.
Morikawa Y, Overton HA, Moore JP, Wilkinson AJ, Brady RL, Lewis SJ, Jones IM
AIDS Res Hum Retroviruses. 1990
PubMed ID: 2364018
Relative inefficiency of soluble recombinant CD4 for inhibition of infection by monocyte-tropic HIV in monocytes and T cells.
Gomatos PJ, Stamatos NM, Gendelman HE, Fowler A, Hoover DL, Kalter DC, Burke DS, Tramont EC, Meltzer MS
J Immunol. 1990
PubMed ID: 2341717
Role of N-linked glycans of envelope glycoproteins in infectivity of human immunodeficiency virus type 1.
Fenouillet E, Gluckman JC, Bahraoui E
J Virol. 1990
PubMed ID: 2335819
Expression and characterization of a functional human immunodeficiency virus envelope glycoprotein in insect cells.
Wells DE, Compans RW
Virology. 1990
PubMed ID: 2111957
CD4-derived synthetic peptide blocks the binding of HIV-1 GP120 to CD4-bearing cells and prevents HIV-1 infection.
Shapira-Nahor O, Golding H, Vujcic LK, Resto-Ruiz S, Fields RL, Robey FA
Cell Immunol. 1990
PubMed ID: 1971526
The N-terminal region of the human immunodeficiency virus envelope glycoprotein gp120 contains potential binding sites for CD4.
Syu WJ, Huang JH, Essex M, Lee TH
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2339113
Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants.
Helseth E, Kowalski M, Gabuzda D, Olshevsky U, Haseltine W, Sodroski J
J Virol. 1990
PubMed ID: 2325207
Functional contribution of cysteine residues to the human immunodeficiency virus type 1 envelope.
Tschachler E, Buchow H, Gallo RC, Reitz MS
J Virol. 1990
PubMed ID: 2182910
Human immunodeficiency virus envelope glycoprotein/CD4-mediated fusion of nonprimate cells with human cells.
Ashorn PA, Berger EA, Moss B
J Virol. 1990
PubMed ID: 2109100
The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway.
Chowdhury IH, Koyanagi Y, Kobayashi S, Hamamoto Y, Yoshiyama H, Yoshida T, Yamamoto N
Virology. 1990
PubMed ID: 1970444
Analysis of the site in CD4 that binds to the HIV envelope glycoprotein.
Brodsky MH, Warton M, Myers RM, Littman DR
J Immunol. 1990
PubMed ID: 1691226
Biological properties of a CD4 immunoadhesin.
Byrn RA, Mordenti J, Lucas C, Smith D, Marsters SA, Johnson JS, Cossum P, Chamow SM, Wurm FM, Gregory T
Nature. 1990
PubMed ID: 1970124
HIV envelope glycoprotein, antigen specific T-cell responses, and soluble CD4.
Manca F, Habeshaw JA, Dalgleish AG
Lancet. 1990
PubMed ID: 1690832
Infection of monocytes by human immunodeficiency virus type 1 blocked by inhibitors of CD4-gp120 binding, even in the presence of enhancing antibodies.
Perno CF, Baseler MW, Broder S, Yarchoan R
J Exp Med. 1990
PubMed ID: 2324685
Characterization of recombinant gp120 and gp160 from HIV-1: binding to monoclonal antibodies and soluble CD4.
Moore JP, McKeating JA, Jones IM, Stephens PE, Clements G, Thomson S, Weiss RA
AIDS. 1990
PubMed ID: 2190605
Simple methods for monitoring HIV-1 and HIV-2 gp120 binding to soluble CD4 by enzyme-linked immunosorbent assay: HIV-2 has a 25-fold lower affinity than HIV-1 for soluble CD4.
Moore JP
AIDS. 1990
PubMed ID: 2190604
Dextran sulfate and other polyanionic anti-HIV compounds specifically interact with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1.
Schols D, Pauwels R, Desmyter J, De Clercq E
Virology. 1990
PubMed ID: 1691563
HIV-1 transmission and function of virus-infected monocytes/macrophages.
Mann DL, Gartner S, Le Sane F, Buchow H, Popovic M
J Immunol. 1990
PubMed ID: 1690236
A CD4 domain important for HIV-mediated syncytium formation lies outside the virus binding site.
Camerini D, Seed B
Cell. 1990
PubMed ID: 2107024
Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.
Kalyanaraman VS, Rodriguez V, Veronese F, Rahman R, Lusso P, DeVico AL, Copeland T, Oroszlan S, Gallo RC, Sarngadharan MG
AIDS Res Hum Retroviruses. 1990
PubMed ID: 2187500
The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced syncytia formation in monocytoid and T cells.
Valentin A, Lundin K, Patarroyo M, Asjö B
J Immunol. 1990
PubMed ID: 1967280
HIV-gp120 can block CD4-class II MHC-mediated adhesion.
Rosenstein Y, Burakoff SJ, Herrmann SH
J Immunol. 1990
PubMed ID: 1967269
Interactions of HIV gp120 with the CD4 molecule on lymphocytes and in the nervous system.
Sattentau QJ
Ann N Y Acad Sci. 1990
PubMed ID: 2198840
Production and characterization of a fragment containing the HIV-gp120 binding region of CD4 using a bovine papilloma virus (BPV) vector.
Gidlund M, Sydow M, Stenbeck A, Flodby P, Fossum H, Matsuda S, Lundin K, Wigzell H, Lind P
Arch Virol. 1990
PubMed ID: 2171457
Characterization of an HIV-1 point mutant blocked in envelope glycoprotein cleavage.
Guo HG, Veronese FM, Tschachler E, Pal R, Kalyanaraman VS, Gallo RC, Reitz MS
Virology. 1990
PubMed ID: 2104682
The envelope of HIV-1 as a key component to infectivity.
Buchbinder A
Prog AIDS Pathol. 1990
PubMed ID: 2103853
The genetic analysis of the HIV envelope binding domain on CD4.
Arthos J, Deen KC, Shatzman A, Truneh A, Rosenberg M, Sweet RW
Ann N Y Acad Sci. 1990
PubMed ID: 2078013
Red blood cells bearing CD4 bind to gp120 covered plates and aggregate with cells expressing gp120.
Arvinte T, Schulz B, Madoulet C, Nicolau C
J Acquir Immune Defic Syndr. 1990
PubMed ID: 1698964
Flow cytometric method to monitor the destruction of CD4+ cells following their fusion with HIV-infected cells.
Schols D, Pauwels R, Desmyter J, De Clercq E
Cytometry. 1990
PubMed ID: 1696539
Differences in the interaction of HIV-1 and HIV-2 with CD4.
Looney DJ, Hayashi S, Nicklas M, Redfield RR, Broder S, Wong-Staal F, Mitsuya H
J Acquir Immune Defic Syndr. 1990
PubMed ID: 1693676
The gp120-CD4 interface: structural, immunological and pathological considerations.
Kieber-Emmons T, Jameson BA, Morrow WJ
Biochim Biophys Acta. 1989
PubMed ID: 2559777
Protein and carbohydrate structural analysis of a recombinant soluble CD4 receptor by mass spectrometry.
Carr SA, Hemling ME, Folena-Wasserman G, Sweet RW, Anumula K, Barr JR, Huddleston MJ, Taylor P
J Biol Chem. 1989
PubMed ID: 2592374
Class II MHC molecules and the HIV gp 120 envelope protein interact with functionally distinct regions of the CD4 molecule.
Lamarre D, Capon DJ, Karp DR, Gregory T, Long EO, Sékaly RP
EMBO J. 1989
PubMed ID: 2555159
Effects of mutations in hyperconserved regions of the extracellular glycoprotein of human immunodeficiency virus type 1 on receptor binding.
Cordonnier A, Rivière Y, Montagnier L, Emerman M
J Virol. 1989
PubMed ID: 2550679
Characterization of in vitro inhibition of human immunodeficiency virus by purified recombinant CD4.
Byrn RA, Sekigawa I, Chamow SM, Johnson JS, Gregory TJ, Capon DJ, Groopman JE
J Virol. 1989
PubMed ID: 2550671
A predicted three-dimensional structure for the human immunodeficiency virus binding domains of CD4 antigen.
Bates PA, McGregor MJ, Islam SA, Sattentau QJ, Sternberg MJ
Protein Eng. 1989
PubMed ID: 2479005
Synergism between HIV gp120 and gp120-specific antibody in blocking human T cell activation.
Mittler RS, Hoffmann MK
Science. 1989
PubMed ID: 2571187
A rapid solution immunoassay to quantify binding of the human immunodeficiency virus envelope glycoprotein to soluble CD4.
McQuade TJ, Pitts TW, Tarpley WG
Biochem Biophys Res Commun. 1989
PubMed ID: 2549987
The MHC-binding and gp120-binding functions of CD4 are separable.
Lamarre D, Ashkenazi A, Fleury S, Smith DH, Sekaly RP, Capon DJ
Science. 1989
PubMed ID: 2549633
Single amino-acid changes in HIV envelope affect viral tropism and receptor binding.
Cordonnier A, Montagnier L, Emerman M
Nature. 1989
PubMed ID: 2475780
Expression and immunogenicity of the extracellular domain of the human immunodeficiency virus type 1 envelope glycoprotein, gp160.
Berman PW, Riddle L, Nakamura G, Haffar OK, Nunes WM, Skehel P, Byrn R, Groopman J, Matthews T, Gregory T
J Virol. 1989
PubMed ID: 2545918
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding.
Clayton LK, Sieh M, Pious DA, Reinherz EL
Nature. 1989
PubMed ID: 2543930
Identification of the residues in human CD4 critical for the binding of HIV.
Arthos J, Deen KC, Chaikin MA, Fornwald JA, Sathe G, Sattentau QJ, Clapham PR, Weiss RA, McDougal JS, Pietropaolo C
Cell. 1989
PubMed ID: 2541915
HIV-1 GP120-mediated immune suppression and lymphocyte destruction in the absence of viral infection.
Weinhold KJ, Lyerly HK, Stanley SD, Austin AA, Matthews TJ, Bolognesi DP
J Immunol. 1989
PubMed ID: 2468713
Structural features of CD4 required for binding to HIV.
Ibegbu CC, Kennedy MS, Maddon PJ, Deen KC, Hicks D, Sweet RW, McDougal JS
J Immunol. 1989
PubMed ID: 2538505
Role of N-linked glycans in the interaction between the envelope glycoprotein of human immunodeficiency virus and its CD4 cellular receptor. Structural enzymatic analysis.
Fenouillet E, Clerget-Raslain B, Gluckman JC, Guétard D, Montagnier L, Bahraoui E
J Exp Med. 1989
PubMed ID: 2538547
Recognition of HIV glycoprotein gp120 by T cells. Role of monocyte CD4 in the presentation of gp120.
Siliciano RF, Knall C, Lawton T, Berman P, Gregory T, Reinherz EL
J Immunol. 1989
PubMed ID: 2537355
HIV infection of monocytic cells: rôle of antibody-mediated virus binding to Fc-gamma receptors.
Jouault T, Chapuis F, Olivier R, Parravicini C, Bahraoui E, Gluckman JC
AIDS. 1989
PubMed ID: 2523711
Model for intracellular folding of the human immunodeficiency virus type 1 gp120.
Fennie C, Lasky LA
J Virol. 1989
PubMed ID: 2536098
Molecular biology of HIV: new insights into the virus life-cycle.
Cann AJ, Karn J
AIDS. 1989
PubMed ID: 2558687
Cystein 402 of HIV gp 120 is essential for CD4-binding and resistance of gp 120 to intracellular degradation.
Hemming A, Bolmstedt A, Flodby P, Lundberg L, Gidlund M, Wigzell H, Olofsson S
Arch Virol. 1989
PubMed ID: 2558637
Structure and function of the HIV envelope.
McKeating JA, Willey RL
AIDS. 1989
PubMed ID: 2482055
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.
Diamond DC, Sleckman BP, Gregory T, Lasky LA, Greenstein JL, Burakoff SJ
J Immunol. 1988
PubMed ID: 2846691
Binding region for human immunodeficiency virus (HIV) and epitopes for HIV-blocking monoclonal antibodies of the CD4 molecule defined by site-directed mutagenesis.
Mizukami T, Fuerst TR, Berger EA, Moss B
Proc Natl Acad Sci U S A. 1988
PubMed ID: 2461565
Corrected CD4 sequence.
Littman DR, Maddon PJ, Axel R
Cell. 1988
PubMed ID: 3263213
Increased expression of CD4 molecules on Jurkat cells mediated by human immunodeficiency virus tat protein.
Koka P, Yunis J, Passarelli AL, Dubey DP, Faller DV, Ynis EJ
J Virol. 1988
PubMed ID: 2845147
95- and 25-kDa fragments of the human immunodeficiency virus envelope glycoprotein gp120 bind to the CD4 receptor.
Nygren A, Bergman T, Matthews T, Jörnvall H, Wigzell H
Proc Natl Acad Sci U S A. 1988
PubMed ID: 2842778
Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 (CD4) and requires the intact variable-region-like domain.
Richardson NE, Brown NR, Hussey RE, Vaid A, Matthews TJ, Bolognesi DP, Reinherz EL
Proc Natl Acad Sci U S A. 1988
PubMed ID: 3261864
Cellular immune response to viral peptides in patients exposed to HIV.
Ahearne PM, Matthews TJ, Lyerly HK, White GC, Bolognesi DP, Weinhold KJ
AIDS Res Hum Retroviruses. 1988
PubMed ID: 2462895
The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4.
Landau NR, Warton M, Littman DR
Nature. 1988
PubMed ID: 3260352
Location and chemical synthesis of a binding site for HIV-1 on the CD4 protein.
Jameson BA, Rao PE, Kong LI, Hahn BH, Shaw GM, Hood LE, Kent SB
Science. 1988
PubMed ID: 2453925
Human immunodeficiency virus induces phosphorylation of its cell surface receptor.
Fields AP, Bednarik DP, Hess A, May WS
Nature. 1988
PubMed ID: 3259291
Second conserved domain of gp120 is important for HIV infectivity and antibody neutralization.
Ho DD, Kaplan JC, Rackauskas IE, Gurney ME
Science. 1988
PubMed ID: 2830667
A soluble CD4 protein selectively inhibits HIV replication and syncytium formation.
Hussey RE, Richardson NE, Kowalski M, Brown NR, Chang HC, Siliciano RF, Dorfman T, Walker B, Sodroski J, Reinherz EL
Nature. 1988
PubMed ID: 2829023
HIV infection is blocked in vitro by recombinant soluble CD4.
Fisher RA, Bertonis JM, Meier W, Johnson VA, Costopoulos DS, Liu T, Tizard R, Walker BD, Hirsch MS, Schooley RT
Nature. 1988
PubMed ID: 2829022
In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity.
Willey RL, Smith DH, Lasky LA, Theodore TS, Earl PL, Moss B, Capon DJ, Martin MA
J Virol. 1988
PubMed ID: 3257102
Mapping of the Ly-4 (L3T4) T-cell differentiation antigen on mouse chromosome 6 by the use of RFLPs in an interspecific cross.
Seldin MF, D'Hoostelaere LA, Huppi K, Mock BA, Steinberg AD, Parnes JR, Morse HC
Immunogenetics. 1988
PubMed ID: 2895734
Inhibitory influences of envelope glycoproteins of HIV-1 on normal immune responses.
Chirmule N, Kalyanaraman V, Oyaizu N, Pahwa S
J Acquir Immune Defic Syndr. 1988
PubMed ID: 2851650
Structure and expression of the human and mouse T4 genes.
Maddon PJ, Molineaux SM, Maddon DE, Zimmerman KA, Godfrey M, Alt FW, Chess L, Axel R
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3501122
L3T4 and the immunoglobulin gene superfamily: new relationships between the immune system and the nervous system.
Parnes JR, Hunkapiller T
Immunol Rev. 1987
PubMed ID: 3326818
HIV env glycoprotein shares a cross-reacting epitope with a surface protein present on activated human monocytes and involved in antigen presentation.
Beretta A, Grassi F, Pelagi M, Clivio A, Parravicini C, Giovinazzo G, Andronico F, Lopalco L, Verani P, Buttò S
Eur J Immunol. 1987
PubMed ID: 2446880
HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product.
Guy B, Kieny MP, Riviere Y, Le Peuch C, Dott K, Girard M, Montagnier L, Lecocq JP
Nature. 1987
PubMed ID: 3118220
Structure of the mouse gene encoding CD4 and an unusual transcript in brain.
Gorman SD, Tourvieille B, Parnes JR
Proc Natl Acad Sci U S A. 1987
PubMed ID: 2823269
Antibodies to human immunodeficiency virus in human sera induce cell-mediated lysis of human immunodeficiency virus-infected cells.
Ojo-Amaize EA, Nishanian P, Keith DE, Houghton RL, Heitjan DF, Fahey JL, Giorgi JV
J Immunol. 1987
PubMed ID: 2821115
Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor.
Lasky LA, Nakamura G, Smith DH, Fennie C, Shimasaki C, Patzer E, Berman P, Gregory T, Capon DJ
Cell. 1987
PubMed ID: 2441877
Neutralizing antibodies in HIV (HTLV-III) infection: correlation with clinical outcome and antibody response against different viral proteins.
Ranki A, Weiss SH, Valle SL, Antonen J, Krohn KJ
Clin Exp Immunol. 1987
PubMed ID: 3652531
Sequential changes in antibody levels to the env and gag antigens in human immunodeficiency virus infected subjects.
Manca N, di Marzo Veronese F, Ho DD, Gallo RC, Sarngadharan MG
Eur J Epidemiol. 1987
PubMed ID: 3497054
HTLV-III neutralizing antibody development in transfusion-dependent seropositive patients with beta-thalassemia.
Robert-Guroff M, Giardina PJ, Robey WG, Jennings AM, Naugle CJ, Akbar AN, Grady RW, Hilgartner MW
J Immunol. 1987
PubMed ID: 3495568
Helper T-cell antigenic site identification in the acquired immunodeficiency syndrome virus gp120 envelope protein and induction of immunity in mice to the native protein using a 16-residue synthetic peptide.
Cease KB, Margalit H, Cornette JL, Putney SD, Robey WG, Ouyang C, Streicher HZ, Fischinger PJ, Gallo RC, DeLisi C
Proc Natl Acad Sci U S A. 1987
PubMed ID: 2438696
Human immunodeficiency virus neutralizing antibodies recognize several conserved domains on the envelope glycoproteins.
Ho DD, Sarngadharan MG, Hirsch MS, Schooley RT, Rota TR, Kennedy RC, Chanh TC, Sato VL
J Virol. 1987
PubMed ID: 2437327
Detection of HIV envelope specific antibodies by immunoelectron microscopy and correlation with antibody titer and virus neutralizing activity.
Hausmann EH, Gelderblom HR, Clapham PR, Pauli G, Weiss RA
J Virol Methods. 1987
PubMed ID: 3038935
A conserved region at the COOH terminus of human immunodeficiency virus gp120 envelope protein contains an immunodominant epitope.
Palker TJ, Matthews TJ, Clark ME, Cianciolo GJ, Randall RR, Langlois AJ, White GC, Safai B, Snyderman R, Bolognesi DP
Proc Natl Acad Sci U S A. 1987
PubMed ID: 2436231
The gene encoding the mouse T cell differentiation antigen L3T4 is located on chromosome 6.
Field EH, Tourvieille B, D'Eustachio P, Parnes JR
J Immunol. 1987
PubMed ID: 3102608
Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains.
Clark SJ, Jefferies WA, Barclay AN, Gagnon J, Williams AF
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3104900
A specific assay measuring binding of 125I-Gp 120 from HIV to T4+/CD4+ cells.
Lundin K, Nygren A, Arthur LO, Robey WG, Morein B, Ramstedt U, Gidlund M, Wigzell H
J Immunol Methods. 1987
PubMed ID: 3029227
Sera from HTLV-III/LAV antibody-positive individuals mediate antibody-dependent cellular cytotoxicity against HTLV-III/LAV-infected T cells.
Rook AH, Lane HC, Folks T, McCoy S, Alter H, Fauci AS
J Immunol. 1987
PubMed ID: 3027168
Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene.
Littman DR, Gettner SN
Nature. 1987
PubMed ID: 3027575
Vasoactive intestinal peptide 1-12: a ligand for the CD4 (T4)/human immunodeficiency virus receptor.
Sacerdote P, Ruff MR, Pert CB
J Neurosci Res. 1987
PubMed ID: 3682024
Analysis of human serum antibodies to human immunodeficiency virus (HIV) using recombinant ENV and GAG antigens.
Kenealy W, Reed D, Cybulski R, Tribe D, Taylor P, Stevens C, Matthews T, Petteway S
AIDS Res Hum Retroviruses. 1987
PubMed ID: 3304356
Anti-GP 120 antibodies from HIV seropositive individuals mediate broadly reactive anti-HIV ADCC.
Lyerly HK, Reed DL, Matthews TJ, Langlois AJ, Ahearne PA, Petteway SR, Weinhold KJ
AIDS Res Hum Retroviruses. 1987
PubMed ID: 2833917
Characterization of serum neutralization response to the human immunodeficiency virus (HIV).
Groopman JE, Benz PM, Ferriani R, Mayer K, Allan JD, Weymouth LA
AIDS Res Hum Retroviruses. 1987
PubMed ID: 2441727
HTLV-III/LAV-neutralizing antibodies to an E. coli-produced fragment of the virus envelope.
Putney SD, Matthews TJ, Robey WG, Lynn DL, Robert-Guroff M, Mueller WT, Langlois AJ, Ghrayeb J, Petteway SR, Weinhold KJ
Science. 1986
PubMed ID: 2431482
Restricted neutralization of divergent human T-lymphotropic virus type III isolates by antibodies to the major envelope glycoprotein.
Matthews TJ, Langlois AJ, Robey WG, Chang NT, Gallo RC, Fischinger PJ, Bolognesi DP
Proc Natl Acad Sci U S A. 1986
PubMed ID: 2432599
Induction of anti-HIV neutralizing antibodies by synthetic peptides.
Chanh TC, Dreesman GR, Kanda P, Linette GP, Sparrow JT, Ho DD, Kennedy RC
EMBO J. 1986
PubMed ID: 3466790
Human immunodeficiency virus gp120 glycoprotein detected by a monoclonal antibody to a synthetic peptide.
Chanh TC, Kennedy RC, Alderete BE, Kanda P, Eichberg JW, Dreesman GR
Eur J Immunol. 1986
PubMed ID: 3023102
Shedding and interspecies type sero-reactivity of the envelope glycopolypeptide gp120 of the human immunodeficiency virus.
Schneider J, Kaaden O, Copeland TD, Oroszlan S, Hunsmann G
J Gen Virol. 1986
PubMed ID: 2431105
Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain.
Tourvieille B, Gorman SD, Field EH, Hunkapiller T, Parnes JR
Science. 1986
PubMed ID: 3094146
Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein.
Lifson JD, Feinberg MB, Reyes GR, Rabin L, Banapour B, Chakrabarti S, Moss B, Wong-Staal F, Steimer KS, Engleman EG
Nature. 1986
PubMed ID: 3095663
Prospect for prevention of human immunodeficiency virus infection: purified 120-kDa envelope glycoprotein induces neutralizing antibody.
Robey WG, Arthur LO, Matthews TJ, Langlois A, Copeland TD, Lerche NW, Oroszlan S, Bolognesi DP, Gilden RV, Fischinger PJ
Proc Natl Acad Sci U S A. 1986
PubMed ID: 3018753
Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity.
Sodroski J, Goh WC, Rosen C, Campbell K, Haseltine WA
Nature. 1986
PubMed ID: 3016552
Partial primary structure of the T4 antigens of mouse and sheep: assignment of intrachain disulfide bonds.
Classon BJ, Tsagaratos J, McKenzie IF, Walker ID
Proc Natl Acad Sci U S A. 1986
PubMed ID: 3086886
The gene encoding the T-cell surface protein T4 is located on human chromosome 12.
Isobe M, Huebner K, Maddon PJ, Littman DR, Axel R, Croce CM
Proc Natl Acad Sci U S A. 1986
PubMed ID: 3086883
New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM).
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PubMed ID: 3006256
Antibodies to human T-lymphotropic virus type III (HTLV-III) in saliva of acquired immunodeficiency syndrome (AIDS) patients and in persons at risk for AIDS.
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Blood. 1986
PubMed ID: 3484980
Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule.
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Science. 1986
PubMed ID: 3001934
The L3T4 antigen in mouse and the sheep equivalent are immunoglobulin-like.
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Immunogenetics. 1986
PubMed ID: 3082751
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Retroviruses associated with leukemia and ablative syndromes in animals and in human beings.
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The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.
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Virus envelope protein of HTLV-III represents major target antigen for antibodies in AIDS patients.
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Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III.
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The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus.
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Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	920	12504	24932
EnsEMBL Gene(s)	ENSG00000010610	ENSMUSG00000023274	ENSRNOG00000016294
Unigene	Hs.631659	Mm.2209	Rn.10748
Homologene	CD4	Cd4	Cd4
OMIM	186940	N/A	N/A
GeneCards	CD4	N/A	N/A
Beta Cell Genomics	DT.100770953 DT.121200495 DT.92414799 DT.95220970	DT.87068508 DT.91436625 DT.94130300	N/A
Reactome	P01730	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	920	12504	24932

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
CD4	FARSB	BioGRID	empirical	15047060
CD4	LRPPRC	BioGRID	empirical	15047060
CD4	DHRS2	BioGRID	empirical	15047060
CD4	STUB1	BioGRID	empirical	20974815
CD4	MYL12A	BioGRID	empirical	15047060
CD4	CCR5	HPRD, IntAct, BioGRID	empirical	10816381 15660419
CD4	MAPK14	BioGRID	empirical	20530479
CD4	CTSD	HPRD	empirical	11581410
CD4	DDX3X	BioGRID	empirical	15047060
CD4	DDX5	BioGRID	empirical	15047060
CD4	DEFA3	Reactome	predicted	15210812
CD4	DPP4	HPRD	empirical	7539755
CD4	EEF1B2	BioGRID	empirical	15047060
CD4	EIF4A2	BioGRID	empirical	15047060
CD4	ENO1	BioGRID	empirical	15047060
CD4	EPS15	BioGRID	empirical	16497223
CD4	FCGR3A	HPRD	empirical	11756173
CD4	GAPDH	BioGRID	empirical	15047060
CD4	LAT	HPRD	empirical	10562325
CD4	NR3C1	MINT, BioGRID	empirical	16888650
CD4	ANXA1	BioGRID	empirical	15047060
CD4	ANXA2	BioGRID	empirical	15047060
CD4	ANXA6	BioGRID	empirical	15047060
CD4	HLA-DPA1	HPRD	empirical	12899833
CD4	HLA-DQA1	IntAct	empirical	11535811
CD4	HLA-DQA2	HPRD	empirical	11535811
CD4	HLA-DQB1	HPRD, IntAct	empirical	11535811
CD4	HNRNPA1	BioGRID	empirical	15047060
CD4	HNRNPA2B1	BioGRID	empirical	15047060
CD4	HNRNPD	BioGRID	empirical	15047060
CD4	HNRNPH1	BioGRID	empirical	15047060
CD4	HSPA8	BioGRID	empirical	15047060
CD4	HSP90AA1	BioGRID	empirical	15047060
CD4	HSP90AB1	BioGRID	empirical	15047060
CD4	HSPD1	BioGRID	empirical	15047060
CD4	IL2RA	HPRD	empirical	7539755
CD4	IL16	HPRD, BioGRID	empirical	1851800 7910967
CD4	INPPL1	IntAct	empirical	21988832
CD4	CD82	HPRD, BioGRID	empirical	7636191
CD4	ARF1	Reactome	predicted	15202998
CD4	KPNB1	BioGRID	empirical	15047060
CD4	LCK	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	11854499 8104794 16888650 17005671 8246987 7664803 7486703 12007789 15047060 15084594 16364187 15489910 15489916 11827988
CD4	LGALS1	HPRD, BioGRID	empirical	10490978
CD4	MME	BioGRID	empirical	15047060
CD4	NCL	BioGRID	empirical	15047060
CD4	NPM1	BioGRID	empirical	15047060
CD4	ATP5A1	BioGRID	empirical	15047060
CD4	SPG21	HPRD, BioGRID	empirical	11113139
CD4	ATP6V1H	Reactome	predicted	2014052
CD4	ABCB1	IntAct	empirical	21988832
CD4	PHB	BioGRID	empirical	15047060
CD4	PIK3R1	HPRD	empirical	8246987
CD4	PI4KA	HPRD	empirical	8246987
CD4	PIP	HPRD, BioGRID	empirical	10820003
CD4	MARCH4	HPRD	empirical	14722266
CD4	PTPRC	HPRD, BioGRID	empirical	1834739
CD4	PTPRCAP	IntAct	empirical	10318863
CD4	ACTB	IntAct	empirical	15047060
CD4	RPL7	BioGRID	empirical	15047060
CD4	RPL18	BioGRID	empirical	15047060
CD4	RPL22	BioGRID	empirical	15047060
CD4	RPLP0	BioGRID	empirical	15047060
CD4	RPLP1	BioGRID	empirical	15047060
CD4	RPS9	BioGRID	empirical	15047060
CD4	RPS10	BioGRID	empirical	15047060
CD4	RPS19	BioGRID	empirical	15047060
CD4	CXCL12	HPRD	empirical	10600606
CD4	SELL	HPRD	empirical	7539755
CD4	SSRP1	BioGRID	empirical	15047060
CD4	SYK	BioGRID	empirical	7539035
CD4	TFRC	HPRD	empirical	14705953
CD4	UBC	BioGRID	empirical	17937819 17604280 16497223 20442859 20974815 12832421
CD4	VDAC1	BioGRID	empirical	15047060
CD4	VDAC3	BioGRID	empirical	15047060
CD4	VIM	BioGRID	empirical	15047060
CD4	ZAP70	BioGRID	empirical	7539035
CD4	CXCR4	HPRD	empirical	15660419
CD4	UBL7	IntAct	empirical	21988832
CD4	KCNAB2	HPRD, BioGRID	empirical	12893943
CD4	EIF3B	BioGRID	empirical	15047060
CD4	EIF3D	BioGRID	empirical	15047060
CD4	EIF3I	BioGRID	empirical	15047060
CD4	TNFRSF10A	HPRD	empirical	7650480
CD4	BTRC	BioGRID	empirical	9660940
CD4	UNC119	HPRD, BioGRID	empirical	14757743
CD4	CD2	HPRD	empirical	7539755
CD4	CD4	HPRD, BioGRID	empirical	12444132 15047060
CD4	CD5	HPRD	empirical	7539755
CD4	CD28	HPRD	empirical	7539755
CD4	CD38	HPRD	empirical	7539755
CD4	CD44	HPRD	empirical	7539755
CD4	CD53	HPRD	empirical	7539755
CD4	CD81	BioGRID	empirical	7636191