Home ACVR2A
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(Human) GRCh37 - chr2:148602086..148688393 (86.31 kb) View in Genome Browser
(Mouse) NCBIM37 - chr2:48669629..48758789 (89.16 kb) View in Genome Browser
(Rat) RGSC3.4 - chr3:29779472..29808885 (29.41 kb) View in Genome Browser
HaemAtlas Expression Table for ACVR2A:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for ACVR2A:The ACVR2A interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| ACVR2A | DAXX | IntAct | empirical | 11483955 |
| ACVR2A | ENG | HPRD, BioGRID | empirical | 9872992 |
| ACVR2A | GDF9 | HPRD | empirical | 12135884 |
| ACVR2A | TCTEX1D4 | HPRD | empirical | 16982625 |
| ACVR2A | IGSF1 | HPRD, BioGRID | empirical | 11266516 |
| ACVR2A | INHA | BioGRID | empirical | 10746731 |
| ACVR2A | INHBA | HPRD, BioGRID | empirical | 11266516 10746731 9202237 |
| ACVR2A | INHBB | HPRD, BioGRID | empirical | 11266516 9202237 |
| ACVR2A | INHBC | HPRD | empirical | 12651901 |
| ACVR2A | SYNJ2BP | HPRD, BioGRID | empirical | 11882656 15451561 |
| ACVR2A | CFC1 | Reactome | predicted | |
| ACVR2A | BMP6 | HPRD, BioGRID | empirical | 10504300 |
| ACVR2A | BMP7 | HPRD, MINT, IntAct, BioGRID | empirical | 9748228 12667445 |
| ACVR2A | BMPR1B | MIPS | empirical | 8612709 |
| ACVR2A | TDGF1 | Reactome | predicted | |
| ACVR2A | TGFBR3 | HPRD | empirical | 10746731 |
| ACVR2A | UBC | BioGRID | empirical | 21139048 21906983 |
| ACVR2A | GDF5 | HPRD, BioGRID | empirical | 8702914 |
| ACVR2A | ACVR1 | MIPS | empirical | 8612709 |
| ACVR2A | ACVR1B | MIPS, BioGRID, Reactome | empirical | 8612709 9892009 8721982 9459292 8622651 11117535 15123686 |
| ACVR2A | ACVRL1 | HPRD, MIPS | empirical | 10187774 8612709 |
| ACVR2A | MAGI2 | HPRD, MINT, BioGRID | empirical | 10681527 15451561 |
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Type 1 Diabetes Publications: 3
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Inhibition of activin signaling induces pancreatic epithelial cell expansion and diminishes terminal differentiation of pancreatic beta-cells.
Zhang YQ, Cleary MM, Si Y, Liu G, Eto Y, Kritzik M, Dabernat S, Kayali AG, Sarvetnick N
Diabetes. 2004
PubMed ID: 15277382
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Activin receptor patterning of foregut organogenesis.
Kim SK, Hebrok M, Li E, Oh SP, Schrewe H, Harmon EB, Lee JS, Melton DA
Genes Dev. 2000
PubMed ID: 10921901
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Impaired differentiation of endocrine and exocrine cells of the pancreas in transgenic mouse expressing the truncated type II activin receptor.
Shiozaki S, Tajima T, Zhang YQ, Furukawa M, Nakazato Y, Kojima I
Biochim Biophys Acta. 1999
PubMed ID: 10231550
Publications: 149
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Activin A stimulates mouse macrophages to express APRIL via the Smad3 and ERK/CREB pathways.
Lee HJ, Seo GY, Kim JH, Lee MR, Kim PH
Immunol Lett. 2011
PubMed ID: 21784102
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BMPR-II is dispensable for formation of the limb skeleton.
Gamer LW, Tsuji K, Cox K, Capelo LP, Lowery J, Beppu H, Rosen V
Genesis. 2011
PubMed ID: 21538804
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Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.
Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D, Lin ML, Teague J, Bignell G, Butler A, Cho J, Dalgliesh GL, Galappaththige D, Greenman C, Hardy C, Jia M, Latimer C, Lau KW, Marshall J, McLaren S, Menzies A, Mudie L, Stebbings L, Largaespada DA, Wessels LF, Richard S, Kahnoski RJ, Anema J, Tuveson DA, Perez-Mancera PA, Mustonen V, Fischer A, Adams DJ, Rust A, Chan-on W, Subimerb C, Dykema K, Furge K, Campbell PJ, Teh BT, Stratton MR, Futreal PA
Nature. 2011
PubMed ID: 21248752
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Growth differentiation factor 11 signaling controls retinoic acid activity for axial vertebral development.
Lee YJ, McPherron A, Choe S, Sakai Y, Chandraratna RA, Lee SJ, Oh SP
Dev Biol. 2010
PubMed ID: 20801112
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A large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ
Hum Genet. 2010
PubMed ID: 20734064
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Identification and analysis of type II TGF-β receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells.
Wu N, Zhao Y, Yin Y, Zhang Y, Luo J
Acta Biochim Biophys Sin (Shanghai). 2010
PubMed ID: 20801928
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Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium.
Canzian F, Cox DG, Setiawan VW, Stram DO, Ziegler RG, Dossus L, Beckmann L, Blanché H, Barricarte A, Berg CD, Bingham S, Buring J, Buys SS, Calle EE, Chanock SJ, Clavel-Chapelon F, DeLancey JO, Diver WR, Dorronsoro M, Haiman CA, Hallmans G, Hankinson SE, Hunter DJ, Hüsing A, Isaacs C, Khaw KT, Kolonel LN, Kraft P, Le Marchand L, Lund E, Overvad K, Panico S, Peeters PH, Pollak M, Thun MJ, Tjønneland A, Trichopoulos D, Tumino R, Yeager M, Hoover RN, Riboli E, Thomas G, Henderson BE, Kaaks R, Feigelson HS
Hum Mol Genet. 2010
PubMed ID: 20634197
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Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
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Family-based analysis of candidate genes for polycystic ovary syndrome.
Ewens KG, Stewart DR, Ankener W, Urbanek M, McAllister JM, Chen C, Baig KM, Parker SC, Margulies EH, Legro RS, Dunaif A, Strauss JF, Spielman RS
J Clin Endocrinol Metab. 2010
PubMed ID: 20200332
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Mesalazine reduces mutations in transforming growth factor beta receptor II and activin type II receptor by improvement of replication fidelity in mononucleotide repeats.
Campregher C, Honeder C, Chung H, Carethers JM, Gasche C
Clin Cancer Res. 2010
PubMed ID: 20197483
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L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, Niu T, Hosoya T
Nephron Clin Pract. 2010
PubMed ID: 20424473
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Genome-wide association of lipid-lowering response to statins in combined study populations.
Barber MJ, Mangravite LM, Hyde CL, Chasman DI, Smith JD, McCarty CA, Li X, Wilke RA, Rieder MJ, Williams PT, Ridker PM, Chatterjee A, Rotter JI, Nickerson DA, Stephens M, Krauss RM
PLoS One. 2010
PubMed ID: 20339536
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Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).
Ahn J, Schumacher FR, Berndt SI, Pfeiffer R, Albanes D, Andriole GL, Ardanaz E, Boeing H, Bueno-de-Mesquita B, Chanock SJ, Clavel-Chapelon F, Diver WR, Feigelson HS, Gaziano JM, Giovannucci E, Haiman CA, Henderson BE, Hoover RN, Kolonel LN, Kraft P, Ma J, Le Marchand L, Overvad K, Palli D, Stattin P, Stampfer M, Stram DO, Thomas G, Thun MJ, Travis RC, Trichopoulos D, Virtamo J, Weinstein SJ, Yeager M, Kaaks R, Hunter DJ, Hayes RB
Hum Mol Genet. 2009
PubMed ID: 19574343
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Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations.
Tougeron D, Fauquembergue E, Rouquette A, Le Pessot F, Sesboüé R, Laurent M, Berthet P, Mauillon J, Di Fiore F, Sabourin JC, Michel P, Tosi M, Frébourg T, Latouche JB
Mod Pathol. 2009
PubMed ID: 19503063
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Activin receptor signaling regulates prostatic epithelial cell adhesion and viability.
Simon DP, Vadakkadath Meethal S, Wilson AC, Gallego MJ, Weinecke SL, Bruce E, Lyons PF, Haasl RJ, Bowen RL, Atwood CS
Neoplasia. 2009
PubMed ID: 19308291
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Genetic association of the activin A receptor gene (ACVR2A) and pre-eclampsia.
Fitzpatrick E, Johnson MP, Dyer TD, Forrest S, Elliott K, Blangero J, Brennecke SP, Moses EK
Mol Hum Reprod. 2009
PubMed ID: 19126782
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Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study).
Roten LT, Johnson MP, Forsmo S, Fitzpatrick E, Dyer TD, Brennecke SP, Blangero J, Moses EK, Austgulen R
Eur J Hum Genet. 2009
PubMed ID: 18781190
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ActRIIA and BMPRII Type II BMP receptor subunits selectively required for Smad4-independent BMP7-evoked chemotaxis.
Perron JC, Dodd J
PLoS One. 2009
PubMed ID: 20011660
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Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms.
Jung B, Gomez J, Chau E, Cabral J, Lee JK, Anselm A, Slowik P, Ream-Robinson D, Messer K, Sporn J, Shin SK, Boland CR, Goel A, Carethers JM
PLoS One. 2009
PubMed ID: 20011542
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Dicer is required for maintaining adult pancreas.
Morita S, Hara A, Kojima I, Horii T, Kimura M, Kitamura T, Ochiya T, Nakanishi K, Matoba R, Matsubara K, Hatada I
PLoS ONE. 2009
PubMed ID: 19148298
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Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064572
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BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.
Kamiya N, Ye L, Kobayashi T, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y
Development. 2008
PubMed ID: 18927151
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Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
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A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.
Sengle G, Ono RN, Lyons KM, Bächinger HP, Sakai LY
J Mol Biol. 2008
PubMed ID: 18621057
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BMP-2/4 and BMP-6/7 Differentially Utilize Cell Surface Receptors to Induce Osteoblastic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells.
Lavery K, Swain P, Falb D, Alaoui-Ismaili MH
J Biol Chem. 2008
PubMed ID: 18436533
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GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
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Mutation rates of TGFBR2 and ACVR2 coding microsatellites in human cells with defective DNA mismatch repair.
Chung H, Young DJ, Lopez CG, Le TA, Lee JK, Ream-Robinson D, Huang SC, Carethers JM
PLoS ONE. 2008
PubMed ID: 18941508
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Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development.
Andersson O, Bertolino P, Ibáñez CF
Dev Biol. 2007
PubMed ID: 17936261
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Activin subunit and receptor expression in normal and cleft human fetal palate tissues.
Lambert-Messerlian G, Eklund E, Pinar H, Tantravahi U, Schneyer AL
Pediatr Dev Pathol. 2007
PubMed ID: 18001154
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Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4.
Xia Y, Yu PB, Sidis Y, Beppu H, Bloch KD, Schneyer AL, Lin HY
J Biol Chem. 2007
PubMed ID: 17472960
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Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors.
You KT, Li LS, Kim NG, Kang HJ, Koh KH, Chwae YJ, Kim KM, Kim YK, Park SM, Jang SK, Kim H
PLoS Biol. 2007
PubMed ID: 17456004
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Endofin acts as a Smad anchor for receptor activation in BMP signaling.
Shi W, Chang C, Nie S, Xie S, Wan M, Cao X
J Cell Sci. 2007
PubMed ID: 17356069
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Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
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Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin.
Jung BH, Beck SE, Cabral J, Chau E, Cabrera BL, Fiorino A, Smith EJ, Bocanegra M, Carethers JM
Gastroenterology. 2007
PubMed ID: 17258738
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Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors.
Meng Q, Lux A, Holloschi A, Li J, Hughes JM, Foerg T, McCarthy JE, Heagerty AM, Kioschis P, Hafner M, Garland JM
J Biol Chem. 2006
PubMed ID: 16982625
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Generation of activin receptor type IIB isoform-specific hypomorphic alleles.
Lee YJ, Hong KH, Yun J, Oh SP
Genesis. 2006
PubMed ID: 16991118
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A global genomic transcriptional code associated with CNS-expressed genes.
Bailey PJ, Klos JM, Andersson E, Karlén M, Källström M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J
Exp Cell Res. 2006
PubMed ID: 16919269
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Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion.
Dudas M, Kim J, Li WY, Nagy A, Larsson J, Karlsson S, Chai Y, Kaartinen V
Dev Biol. 2006
PubMed ID: 16806156
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Structure of the ternary signaling complex of a TGF-beta superfamily member.
Allendorph GP, Vale WW, Choe S
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16672363
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Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers.
Jung B, Smith EJ, Doctolero RT, Gervaz P, Alonso JC, Miyai K, Keku T, Sandler RS, Carethers JM
Int J Cancer. 2006
PubMed ID: 16380996
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Characterization of isoforms of activin receptor-interacting protein 2 that augment activin signaling.
Liu ZH, Tsuchida K, Matsuzaki T, Bao YL, Kurisaki A, Sugino H
J Endocrinol. 2006
PubMed ID: 16648306
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BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
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Inhibins are the major activin ligands expressed during early thymocyte development.
Licona P, Chimal-Monroy J, Soldevila G
Dev Dyn. 2006
PubMed ID: 16477644
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Role of prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty.
Vesper AH, Raetzman LT, Camper SA
Endocrinology. 2006
PubMed ID: 16384867
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Regulation of muscle growth by multiple ligands signaling through activin type II receptors.
Lee SJ, Reed LA, Davies MV, Girgenrath S, Goad ME, Tomkinson KN, Wright JF, Barker C, Ehrmantraut G, Holmstrom J, Trowell B, Gertz B, Jiang MS, Sebald SM, Matzuk M, Li E, Liang LF, Quattlebaum E, Stotish RL, Wolfman NM
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16330774
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Truncating mutations in the ACVR2 gene attenuates activin signaling in prostate cancer cells.
Rossi MR, Ionov Y, Bakin AV, Cowell JK
Cancer Genet Cytogenet. 2005
PubMed ID: 16337854
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Impaired male sexual behavior in activin receptor type II knockout mice.
Ma X, Reyna A, Mani SK, Matzuk MM, Kumar TR
Biol Reprod. 2005
PubMed ID: 16093358
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Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification.
Minina E, Schneider S, Rosowski M, Lauster R, Vortkamp A
Gene Expr Patterns. 2005
PubMed ID: 15963767
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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Determinants of trophoblast lineage and cell subtype specification in the mouse placenta.
Simmons DG, Cross JC
Dev Biol. 2005
PubMed ID: 15963972
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Convergence of bone morphogenetic protein and laminin-1 signaling pathways promotes proliferation and colony formation by fetal mouse pancreatic cells.
Jiang FX, Harrison LC
Exp Cell Res. 2005
PubMed ID: 15913604
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Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells.
Yu PB, Beppu H, Kawai N, Li E, Bloch KD
J Biol Chem. 2005
PubMed ID: 15883158
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GDF11 controls the timing of progenitor cell competence in developing retina.
Kim J, Wu HH, Lander AD, Lyons KM, Matzuk MM, Calof AL
Science. 2005
PubMed ID: 15976303
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Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
Nature. 2005
PubMed ID: 15815621
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Gene knockouts that cause female infertility: search for novel contraceptive targets.
Naz RK, Rajesh C
Front Biosci. 2005
PubMed ID: 15970507
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Bone morphogenetic proteins.
Chen D, Zhao M, Mundy GR
Growth Factors. 2004
PubMed ID: 15621726
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Novel factors in regulation of activin signaling.
Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H
Mol Cell Endocrinol. 2004
PubMed ID: 15451561
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population.
Oxburgh L, Chu GC, Michael SK, Robertson EJ
Development. 2004
PubMed ID: 15342483
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
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Elevated levels of activin A in heart failure: potential role in myocardial remodeling.
Yndestad A, Ueland T, Øie E, Florholmen G, Halvorsen B, Attramadal H, Simonsen S, Frøland SS, Gullestad L, Christensen G, Damås JK, Aukrust P
Circulation. 2004
PubMed ID: 14993131
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Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers.
Jung B, Doctolero RT, Tajima A, Nguyen AK, Keku T, Sandler RS, Carethers JM
Gastroenterology. 2004
PubMed ID: 14988818
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Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation.
Martins da Silva SJ, Bayne RA, Cambray N, Hartley PS, McNeilly AS, Anderson RA
Dev Biol. 2004
PubMed ID: 14738881
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
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Regulation of FSHbeta and GnRH receptor gene expression in activin receptor II knockout male mice.
Kumar TR, Agno J, Janovick JA, Conn PM, Matzuk MM
Mol Cell Endocrinol. 2003
PubMed ID: 14654247
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Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors.
Olaru A, Mori Y, Yin J, Wang S, Kimos MC, Perry K, Xu Y, Sato F, Selaru FM, Deacu E, Sterian A, Shibata D, Abraham JM, Meltzer SJ
Lab Invest. 2003
PubMed ID: 14691305
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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Activin signal transduction in the fetal rat adrenal gland and in human H295R cells.
Wang EY, Ma EY, Woodruff TK
J Endocrinol. 2003
PubMed ID: 12844345
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Identification of a functional binding site for activin on the type I receptor ALK4.
Harrison CA, Gray PC, Koerber SC, Fischer W, Vale W
J Biol Chem. 2003
PubMed ID: 12665502
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Localization of activin and inhibin subunits, receptors and SMADs in the mouse mammary gland.
Jeruss JS, Santiago JY, Woodruff TK
Mol Cell Endocrinol. 2003
PubMed ID: 12782414
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Ovarian follicle populations of the rat express TGF-beta signalling pathways.
Drummond AE, Dyson M, Le MT, Ethier JF, Findlay JK
Mol Cell Endocrinol. 2003
PubMed ID: 12770730
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Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas.
Dichmann DS, Miller CP, Jensen J, Scott Heller R, Serup P
Dev Dyn. 2003
PubMed ID: 12666204
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Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia.
Casagrandi D, Bearfield C, Geary J, Redman CW, Muttukrishna S
Mol Hum Reprod. 2003
PubMed ID: 12651901
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Changes in activin and activin receptor subunit expression in rat liver during the development of CCl4-induced cirrhosis.
Gold EJ, Francis RJ, Zimmermann A, Mellor SL, Cranfield M, Risbridger GP, Groome NP, Wheatley AM, Fleming JS
Mol Cell Endocrinol. 2003
PubMed ID: 12706302
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The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly.
Greenwald J, Groppe J, Gray P, Wiater E, Kwiatkowski W, Vale W, Choe S
Mol Cell. 2003
PubMed ID: 12667445
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Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin.
Nakamura M, Matzuk MM, Gerstmayer B, Bosio A, Lauster R, Miyachi Y, Werner S, Paus R
FASEB J. 2003
PubMed ID: 12514121
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BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning.
Oh SP, Yeo CY, Lee Y, Schrewe H, Whitman M, Li E
Genes Dev. 2002
PubMed ID: 12414726
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Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors.
Chapman SC, Bernard DJ, Jelen J, Woodruff TK
Mol Cell Endocrinol. 2002
PubMed ID: 12385827
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Expression of activin/inhibin receptor and binding protein genes and regulation of activin/inhibin peptide secretion in human adrenocortical cells.
Vänttinen T, Kuulasmaa T, Liu J, Voutilainen R
J Clin Endocrinol Metab. 2002
PubMed ID: 12213882
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Bone morphogenetic protein receptor type II is a receptor for growth differentiation factor-9.
Vitt UA, Mazerbourg S, Klein C, Hsueh AJ
Biol Reprod. 2002
PubMed ID: 12135884
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The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction.
Welt CK
Curr Opin Obstet Gynecol. 2002
PubMed ID: 12032389
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Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway.
Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H
J Biol Chem. 2002
PubMed ID: 11882656
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The distribution of activin and activin receptors in gestational tissues across human pregnancy and during labour.
Schneider-Kolsky ME, Manuelpillai U, Waldron K, Dole A, Wallace EM
Placenta. 2002
PubMed ID: 11969340
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Effect of adenovirus-mediated overexpression of follistatin and extracellular domain of activin receptor type II on gonadotropin secretion in vitro and in vivo.
Leal AM, Takabe K, Wang L, Donaldson CJ, MacConell LA, Bilezikjian LM, Verma IM, Vale W
Endocrinology. 2002
PubMed ID: 11861519
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The role of effectors of the activin signalling pathway, activin receptors IIA and IIB, and Smad2, in patterning of tooth development.
Ferguson CA, Tucker AS, Heikinheimo K, Nomura M, Oh P, Li E, Sharpe PT
Development. 2001
PubMed ID: 11714685
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Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Piao Y, Ko NT, Lim MK, Ko MS
Genome Res. 2001
PubMed ID: 11544199
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Uterine-embryonic interaction in pig: activin, follistatin, and activin receptor II in uterus and embryo during early gestation.
van de Pavert SA, Boerjan ML, Stroband HW, Taverne MA, van den Hurk R
Mol Reprod Dev. 2001
PubMed ID: 11468775
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Male reproductive phenotypes in double mutant mice lacking both FSHbeta and activin receptor IIA.
Kumar TR, Varani S, Wreford NG, Telfer NM, de Kretser DM, Matzuk MM
Endocrinology. 2001
PubMed ID: 11459797
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Regulation of myostatin activity and muscle growth.
Lee SJ, McPherron AC
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11459935
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Analysis of the testicular phenotype of the follicle-stimulating hormone beta-subunit knockout and the activin type II receptor knockout mice by stereological analysis.
Wreford NG, Rajendra Kumar T, Matzuk MM, de Kretser DM
Endocrinology. 2001
PubMed ID: 11416011
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Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP).
Chapman SC, Woodruff TK
Mol Endocrinol. 2001
PubMed ID: 11266516
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Activin A and activin receptors in the human thyroid: a link to the female predominance of goiter?
Schulte KM, Jonas C, Krebs R, Röher HD
Horm Metab Res. 2000
PubMed ID: 11069203
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
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BMP type II receptor is required for gastrulation and early development of mouse embryos.
Beppu H, Kawabata M, Hamamoto T, Chytil A, Minowa O, Noda T, Miyazono K
Dev Biol. 2000
PubMed ID: 10772805
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Betaglycan binds inhibin and can mediate functional antagonism of activin signalling.
Lewis KA, Gray PC, Blount AL, MacConell LA, Wiater E, Bilezikjian LM, Vale W
Nature. 2000
PubMed ID: 10746731
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Identification and characterization of a PDZ protein that interacts with activin type II receptors.
Shoji H, Tsuchida K, Kishi H, Yamakawa N, Matsuzaki T, Liu Z, Nakamura T, Sugino H
J Biol Chem. 2000
PubMed ID: 10681527
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Variations in activin receptor, inhibin/activin subunit and follistatin mRNAs in human prostate tumour tissues.
van Schaik RH, Wierikx CD, Timmerman MA, Oomen MH, van Weerden WM, van der Kwast TH, van Steenbrugge GJ, de Jong FH
Br J Cancer. 2000
PubMed ID: 10638976
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Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation.
Ebisawa T, Tada K, Kitajima I, Tojo K, Sampath TK, Kawabata M, Miyazono K, Imamura T
J Cell Sci. 1999
PubMed ID: 10504300
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The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice.
Song J, Oh SP, Schrewe H, Nomura M, Lei H, Okano M, Gridley T, Li E
Dev Biol. 1999
PubMed ID: 10452853
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The disulfide bond arrangement in the extracellular domain of the activin type II receptor.
Fischer WH, Greenwald J, Park M, Craig AG, Choe S, Vale W
J Protein Chem. 1999
PubMed ID: 10449041
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Mutational analysis of activin/transforming growth factor-beta type I and type II receptor kinases in human pituitary tumors.
D'Abronzo FH, Swearingen B, Klibanski A, Alexander JM
J Clin Endocrinol Metab. 1999
PubMed ID: 10323406
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Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1.
Lux A, Attisano L, Marchuk DA
J Biol Chem. 1999
PubMed ID: 10187774
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Vezf1: A Zn finger transcription factor restricted to endothelial cells and their precursors.
Xiong JW, Leahy A, Lee HH, Stuhlmann H
Dev Biol. 1999
PubMed ID: 9986727
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Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily.
Barbara NP, Wrana JL, Letarte M
J Biol Chem. 1999
PubMed ID: 9872992
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Roles of pathway-specific and inhibitory Smads in activin receptor signaling.
Lebrun JJ, Takabe K, Chen Y, Vale W
Mol Endocrinol. 1999
PubMed ID: 9892009
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Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase.
Greenwald J, Fischer WH, Vale WW, Choe S
Nat Struct Biol. 1999
PubMed ID: 9886286
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Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-->q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH.
Bondestam J, Horelli-Kuitunen N, Hildén K, Ritvos O, Aaltonen J
Cytogenet Cell Genet. 1999
PubMed ID: 10702675
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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Molecular mechanisms of vertebrate left-right development.
Ramsdell AF, Yost HJ
Trends Genet. 1998
PubMed ID: 9825674
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Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2.
Macías-Silva M, Hoodless PA, Tang SJ, Buchwald M, Wrana JL
J Biol Chem. 1998
PubMed ID: 9748228
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Concomitant over-expression of activin/inhibin beta subunits and their receptors in human pancreatic cancer.
Kleeff J, Ishiwata T, Friess H, Büchler MW, Korc M
Int J Cancer. 1998
PubMed ID: 9714055
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Identification of a novel type II activin receptor, type IIA-N, induced during the neural differentiation of murine P19 embryonal carcinoma cells.
Shoji H, Nakamura T, van den Eijnden-van Raaij AJ, Sugino H
Biochem Biophys Res Commun. 1998
PubMed ID: 9610356
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Stimulation of activin receptor II signaling pathways inhibits differentiation of multiple gastric epithelial lineages.
Li Q, Karam SM, Coerver KA, Matzuk MM, Gordon JI
Mol Endocrinol. 1998
PubMed ID: 9482661
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Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.
Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J, Beier DR
Genome Res. 1997
PubMed ID: 9371744
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Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells.
Martens JW, de Winter JP, Timmerman MA, McLuskey A, van Schaik RH, Themmen AP, de Jong FH
Endocrinology. 1997
PubMed ID: 9202237
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Osteoblasts express types I and II activin receptors during early intramembranous and endochondral bone formation.
Shuto T, Sarkar G, Bronk JT, Matsui N, Bolander ME
J Bone Miner Res. 1997
PubMed ID: 9076583
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Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation.
Lebrun JJ, Vale WW
Mol Cell Biol. 1997
PubMed ID: 9032295
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Activin and basic fibroblast growth factor regulate neurogenesis of murine embryonal carcinoma cells.
Ameerun RF, de Winter JP, van den Eijnden-van Raaij AJ, den Hertog J, de Laat SW, Tertoolen LG
Cell Growth Differ. 1996
PubMed ID: 8959336
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Fluorescent in situ localization of the bovine activin receptor type IIA locus on chromosome 2 (2q2.3-2.4).
Monteagudo LV, Heriz A, Flavin N, Rogers M, Ennis S, Arruga MV
Mamm Genome. 1996
PubMed ID: 8875905
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Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5.
Nishitoh H, Ichijo H, Kimura M, Matsumoto T, Makishima F, Yamaguchi A, Yamashita H, Enomoto S, Miyazono K
J Biol Chem. 1996
PubMed ID: 8702914
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Activin signaling through activin receptor type II causes the cachexia-like symptoms in inhibin-deficient mice.
Coerver KA, Woodruff TK, Finegold MJ, Mather J, Bradley A, Matzuk MM
Mol Endocrinol. 1996
PubMed ID: 8732684
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Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors.
De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ
Exp Cell Res. 1996
PubMed ID: 8612709
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Inhibitory effects of activin on the growth and morpholgenesis of primary and transformed mammary epithelial cells.
Liu QY, Niranjan B, Gomes P, Gomm JJ, Davies D, Coombes RC, Buluwela L
Cancer Res. 1996
PubMed ID: 8640777
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Activation of signalling by the activin receptor complex.
Attisano L, Wrana JL, Montalvo E, Massagué J
Mol Cell Biol. 1996
PubMed ID: 8622651
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Cloning of the bovine activin receptor type II gene (ACVR2) and mapping to chromosome 2 (BTA2).
Flavin N, Heriz A, Monteagudo LV, Ennis S, Martin F, Barendse W, Arruga MV, Rogers M
Cytogenet Cell Genet. 1996
PubMed ID: 8995483
-
Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome.
Hein L, Dzau VJ, Barsh GS
Genomics. 1995
PubMed ID: 8586443
-
Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis.
Verschueren K, Dewulf N, Goumans MJ, Lonnoy O, Feijen A, Grimsby S, Vandi Spiegle K, ten Dijke P, Morén A, Vanscheeuwijck P, Heldin CH, Miyazono K, Mummery C, Van Den Eijnden-Van Raaij J, Huylebroeck D
Mech Dev. 1995
PubMed ID: 7577669
-
Different phenotypes for mice deficient in either activins or activin receptor type II.
Matzuk MM, Kumar TR, Bradley A
Nature. 1995
PubMed ID: 7885474
-
Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism.
Xu J, McKeehan K, Matsuzaki K, McKeehan WL
J Biol Chem. 1995
PubMed ID: 7890768
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mRNAs for activin receptors II and IIB are expressed in mouse oocytes and in the epiblast of pregastrula and gastrula stage mouse embryos.
Manova K, De Leon V, Angeles M, Kalantry S, Giarré M, Attisano L, Wrana J, Bachvarova RF
Mech Dev. 1995
PubMed ID: 7748787
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Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins.
Feijen A, Goumans MJ, van den Eijnden-van Raaij AJ
Development. 1994
PubMed ID: 7821227
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Overexpression of activin-beta A subunit mRNA is associated with decreased activin type II receptor mRNA levels in the testes of alpha-inhibin deficient mice.
Trudeau VL, Matzuk MM, Haché RJ, Renaud LP
Biochem Biophys Res Commun. 1994
PubMed ID: 8074643
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Expression of activin receptor II and IIB mRNA isoforms in mouse reproductive organs and oocytes.
Wu TC, Jih MH, Wang L, Wan YJ
Mol Reprod Dev. 1994
PubMed ID: 8049070
-
Expression of the type II activin receptor gene in the human placenta.
Peng C, Huang TH, Jeung EB, Donaldson CJ, Vale WW, Leung PC
Endocrinology. 1993
PubMed ID: 8243335
-
Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors.
Attisano L, Cárcamo J, Ventura F, Weis FM, Massagué J, Wrana JL
Cell. 1993
PubMed ID: 8242742
-
Expression of type II activin receptor genes in the male and female reproductive tissues of the rat.
Feng ZM, Madigan MB, Chen CL
Endocrinology. 1993
PubMed ID: 7916681
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Differential expression of inhibin subunits and follistatin, but not of activin receptor type II, during early murine embryonic development.
van den Eijnden-van Raaij AJ, Feijen A, Lawson KA, Mummery CL
Dev Biol. 1992
PubMed ID: 1330789
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Cloning and sequencing of a rat type II activin receptor.
Shinozaki H, Ito I, Hasegawa Y, Nakamura K, Igarashi S, Nakamura M, Miyamoto K, Eto Y, Ibuki Y, Minegishi T
FEBS Lett. 1992
PubMed ID: 1385212
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Structure of the mouse activin receptor type II gene.
Matzuk MM, Bradley A
Biochem Biophys Res Commun. 1992
PubMed ID: 1318045
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Molecular cloning and binding properties of the human type II activin receptor.
Donaldson CJ, Mathews LS, Vale WW
Biochem Biophys Res Commun. 1992
PubMed ID: 1314589
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Cloning of the human activin receptor cDNA reveals high evolutionary conservation.
Matzuk MM, Bradley A
Biochim Biophys Acta. 1992
PubMed ID: 1311955
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Expression cloning of an activin receptor, a predicted transmembrane serine kinase.
Mathews LS, Vale WW
Cell. 1991
PubMed ID: 1646080
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