Home CD247
|
(Human) GRCh37 - chr1:167399877..167487847 (87.97 kb) View in Genome Browser
(Mouse) NCBIM37 - chr1:167718812..167807407 (88.59 kb) View in Genome Browser
(Rat) RGSC3.4 - chr13:81515383..81594699 (79.32 kb) View in Genome Browser
HaemAtlas Expression Table for CD247:|
Expression Legend
|
|
|
Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
| Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Expression Legend
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for CD247:The CD247 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| CD247 | SH2B3 | HPRD | empirical | 10799879 |
| CD247 | TUBA1B | BioGRID | empirical | 15084271 |
| CD247 | TIRAP | HPRD | empirical | 11572860 |
| CD247 | CSK | HPRD | empirical | 9172452 |
| CD247 | DOCK2 | HPRD, BioGRID | empirical | 12176041 |
| CD247 | FCGR3A | HPRD | empirical | 2138330 |
| CD247 | ZNF281 | IntAct | empirical | 21988832 |
| CD247 | FYN | HPRD | empirical | 1454062 1530920 7589084 8760790 9368621 |
| CD247 | NCR3 | HPRD | empirical | 12731048 |
| CD247 | PTPN22 | HPRD, IntAct | empirical | 16461343 |
| CD247 | GRB2 | HPRD | empirical | 7629168 |
| CD247 | JAK3 | HPRD, BioGRID | empirical | 11349123 |
| CD247 | LCK | HPRD, MINT, IntAct | empirical | 9047237 8626561 16461343 |
| CD247 | LY6E | HPRD | empirical | 9575182 |
| CD247 | PAK2 | Reactome | predicted | 16979207 10607567 11070003 16188976 10618429 11160719 16282498 |
| CD247 | TRAT1 | HPRD, BioGRID | empirical | 11390434 9687533 |
| CD247 | CD244 | HPRD | empirical | 16049493 |
| CD247 | PI4K2B | HPRD | empirical | 16337488 |
| CD247 | PTPN3 | HPRD | empirical | 14672952 |
| CD247 | PTPN6 | HPRD | empirical | 14672952 |
| CD247 | PTPRC | HPRD, BioGRID | empirical | 7526385 |
| CD247 | ATXN2 | BioGRID | empirical | 9575182 |
| CD247 | SHC1 | HPRD | empirical | 8656061 |
| CD247 | SLA | HPRD, BioGRID | empirical | 10449770 |
| CD247 | STAT5A | HPRD, BioGRID | empirical | 9880255 |
| CD247 | STAT5B | HPRD, BioGRID | empirical | 9880255 |
| CD247 | TFRC | HPRD | empirical | 9448136 |
| CD247 | UBC | BioGRID | empirical | 11353765 |
| CD247 | VTN | IntAct | empirical | 21988832 |
| CD247 | ZAP70 | HPRD, BioGRID | empirical | 8366117 7737297 11353765 |
| CD247 | PCGF2 | IntAct | empirical | 21988832 |
| CD247 | SLA2 | HPRD | empirical | 11891219 |
| CD247 | CBL | BioGRID | empirical | 11353765 |
| CD247 | UNC119 | HPRD, BioGRID | empirical | 14757743 |
| CD247 | CD2 | HPRD | empirical | 8977276 16049493 |
| CD247 | CD3D | HPRD | empirical | 9485181 |
| CD247 | CD247 | HPRD, IntAct | empirical | 12356870 2845582 17055436 |
| CD247 | CD5 | HPRD | empirical | 1385158 |
| CD247 | CD28 | HPRD | empirical | 8760790 |
| CD247 | NCR1 | HPRD, BioGRID | empirical | 9625766 |
| CD247 | CD48 | HPRD | empirical | 16049493 |
| CD247 | GAB2 | HPRD, BioGRID | empirical | 11572860 |
|
|
||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|
|||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||
|
|
|
Type 1 Diabetes Publications: 4
-
Variation in the Cd3{zeta} (Cd247) Gene Correlates with Altered T Cell Activation and Is Associated with Autoimmune Diabetes.
Lundholm M, Mayans S, Motta V, Löfgren-Burström A, Danska J, Holmberg D
J Immunol. 2010
PubMed ID: 20400699
-
Defective induction of CTLA-4 in the NOD mouse is controlled by the NOD allele of Idd3/IL-2 and a novel locus (Ctex) telomeric on chromosome 1.
Lundholm M, Motta V, Löfgren-Burström A, Duarte N, Bergman ML, Mayans S, Holmberg D
Diabetes. 2006
PubMed ID: 16443792
-
Genetic control of NKT cell numbers maps to major diabetes and lupus loci.
Esteban LM, Tsoutsman T, Jordan MA, Roach D, Poulton LD, Brooks A, Naidenko OV, Sidobre S, Godfrey DI, Baxter AG
J Immunol. 2003
PubMed ID: 12960309
-
Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-zeta-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice.
Salojin K, Zhang J, Cameron M, Gill B, Arreaza G, Ochi A, Delovitch TL
J Exp Med. 1997
PubMed ID: 9294143
Publications: 295
-
Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.
Zhang H, Cordoba SP, Dushek O, Anton van der Merwe P
Proc Natl Acad Sci U S A. 2011
PubMed ID: 22084078
-
The immune molecule CD3zeta and its downstream effectors ZAP-70/Syk mediate ephrin signaling in neurons to regulate early neuritogenesis.
Angibaud J, Louveau A, Baudouin SJ, Nerrière-Daguin V, Evain S, Bonnamain V, Hulin P, Csaba Z, Dournaud P, Thinard R, Naveilhan P, Noraz N, Pellier-Monnin V, Boudin H
J Neurochem. 2011
PubMed ID: 21895656
-
Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes.
Kumar R, Ferez M, Swamy M, Arechaga I, Rejas MT, Valpuesta JM, Schamel WW, Alarcon B, van Santen HM
Immunity. 2011
PubMed ID: 21903423
-
Independent replication establishes the CD247 gene as a genetic systemic sclerosis susceptibility factor.
Dieudé P, Boileau C, Guedj M, Avouac J, Ruiz B, Hachulla E, Diot E, Cracowski JL, Tiev K, Sibilia J, Mouthon L, Frances C, Amoura Z, Carpentier P, Cosnes A, Meyer O, Kahan A, Chiocchia G, Allanore Y
Ann Rheum Dis. 2011
PubMed ID: 21474487
-
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
-
The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse.
DeFord-Watts LM, Dougall DS, Belkaya S, Johnson BA, Eitson JL, Roybal KT, Barylko B, Albanesi JP, Wülfing C, van Oers NS
J Immunol. 2011
PubMed ID: 21543646
-
The expression pattern of CD3 chain genes in fetal/maternal interface.
Lu X, Chen S, Yang L, Zha X, Yang X, Li Y
Hematology. 2011
PubMed ID: 21669059
-
Change in expression pattern of TCR-CD3 complex in patients with multiple myeloma.
Li Y, Chen S, Yang L, Chen S, Lin C, Wang L, Lu Y, Geng S, Du X, Schmidt CA
Hematology. 2011
PubMed ID: 21669053
-
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
Zhernakova A, Stahl EA, Trynka G, Raychaudhuri S, Festen EA, Franke L, Westra HJ, Fehrmann RS, Kurreeman FA, Thomson B, Gupta N, Romanos J, McManus R, Ryan AW, Turner G, Brouwer E, Posthumus MD, Remmers EF, Tucci F, Toes R, Grandone E, Mazzilli MC, Rybak A, Cukrowska B, Coenen MJ, Radstake TR, van Riel PL, Li Y, de Bakker PI, Gregersen PK, Worthington J, Siminovitch KA, Klareskog L, Huizinga TW, Wijmenga C, Plenge RM
PLoS Genet. 2011
PubMed ID: 21383967
-
CD3γ-independent pathways in TCR-mediated signaling in mature T and iNKT lymphocytes.
Reiné J, Busto EM, Muñoz-Ruiz M, Rossi NE, Rodríguez-Fernández JL, Martínez-Naves E, Regueiro JR, Recio MJ
Cell Immunol. 2011
PubMed ID: 21764047
-
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
-
Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3ζ in the endosomal compartment.
Yudushkin IA, Vale RD
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21135224
-
[Change of expression pattern of CD3 genes in peripheral blood T-cells from CML patients].
Yang LJ, Chen SH, Wang L, Chen S, Yu Z, Lu YH, Li YQ
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010
PubMed ID: 20723304
-
Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs.
Becker AM, Blevins JS, Tomson FL, Eitson JL, Medeiros JJ, Yarovinsky F, Norgard MV, van Oers NS
J Immunol. 2010
PubMed ID: 20483726
-
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FA, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Brouwer E, Burtt NP, Catanese JJ, Coblyn J, Coenen MJ, Costenbader KH, Criswell LA, Crusius JB, Cui J, de Bakker PI, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Lee AT, Liu X, Martin P, Morgan AW, Padyukov L, Posthumus MD, Radstake TR, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, van der Schoot CE, van Riel PL, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth BP, YEAR Consortium, Wijmenga C, Karlson EW, Toes RE, de Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM
Nat Genet. 2010
PubMed ID: 20453842
-
The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation.
Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, Lozano G, Dong C
Immunity. 2010
PubMed ID: 20493730
-
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.
Radstake TR, Gorlova O, Rueda B, Martin JE, Alizadeh BZ, Palomino-Morales R, Coenen MJ, Vonk MC, Voskuyl AE, Schuerwegh AJ, Broen JC, van Riel PL, van 't Slot R, Italiaander A, Ophoff RA, Riemekasten G, Hunzelmann N, Simeon CP, Ortego-Centeno N, González-Gay MA, González-Escribano MF, Spanish Scleroderma Group, Airo P, van Laar J, Herrick A, Worthington J, Hesselstrand R, Smith V, de Keyser F, Houssiau F, Chee MM, Madhok R, Shiels P, Westhovens R, Kreuter A, Kiener H, de Baere E, Witte T, Padykov L, Klareskog L, Beretta L, Scorza R, Lie BA, Hoffmann-Vold AM, Carreira P, Varga J, Hinchcliff M, Gregersen PK, Lee AT, Ying J, Han Y, Weng SF, Amos CI, Wigley FM, Hummers L, Nelson JL, Agarwal SK, Assassi S, Gourh P, Tan FK, Koeleman BP, Arnett FC, Martin J, Mayes MD
Nat Genet. 2010
PubMed ID: 20383147
-
Alternative splicing factor/splicing factor 2 regulates the expression of the zeta subunit of the human T cell receptor-associated CD3 complex.
Moulton VR, Tsokos GC
J Biol Chem. 2010
PubMed ID: 20118245
-
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
-
Multiple common variants for celiac disease influencing immune gene expression.
Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Adány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek WH, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA
Nat Genet. 2010
PubMed ID: 20190752
-
The immune protein CD3zeta is required for normal development of neural circuits in the retina.
Xu HP, Chen H, Ding Q, Xie ZH, Chen L, Diao L, Wang P, Gan L, Crair MC, Tian N
Neuron. 2010
PubMed ID: 20188655
-
RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling.
Chae HD, Siefring JE, Hildeman DA, Gu Y, Williams DA
PLoS One. 2010
PubMed ID: 21103055
-
A flow cytometry-based FRET assay to identify and analyse protein-protein interactions in living cells.
Banning C, Votteler J, Hoffmann D, Koppensteiner H, Warmer M, Reimer R, Kirchhoff F, Schubert U, Hauber J, Schindler M
PLoS One. 2010
PubMed ID: 20179761
-
TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.
Lillemeier BF, Mörtelmaier MA, Forstner MB, Huppa JB, Groves JT, Davis MM
Nat Immunol. 2010
PubMed ID: 20010844
-
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW, Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P, YEAR Consortium, Altshuler D, Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA, Worthington J, Klareskog L, Gregersen PK, Daly MJ, Plenge RM
Nat Genet. 2009
PubMed ID: 19898481
-
Differential expression of CD3zeta message and protein in tumor infiltrating lymphocytes from solid tumor specimens and malignant ascites from patients with ovarian carcinoma.
Pappas J, Wolfson AD, Jung WJ, Oleszak EL, Helm CW, Freedman RS, Tsygankov AY, Platsoucas CD
Anticancer Res. 2009
PubMed ID: 20032419
-
New CD3zeta allele showing a 9-bp deletion in the 3'-UT region of the gene.
Aguinaga-Barrilero A, Rodríguez-Pérez N, Pérez-Blas M, Gutiérrez-Calvo A, Martín-Villa JM
Tissue Antigens. 2009
PubMed ID: 19775377
-
[Effects of B7-H1 blockade on biologic activity of CD3AK cells in vitro]
Wang YH, Zhuang QY, Hu ZQ, Lan RZ, Zhou SW
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009
PubMed ID: 19664385
-
The CD3Z 844 T>A polymorphism within the 3'-UTR of CD3Z confers increased risk of incidence of systemic lupus erythematosus.
Warchoł T, Piotrowski P, Lianeri M, Cieślak D, Wudarski M, Hrycaj P, Lacki JK, Jagodziński PP
Tissue Antigens. 2009
PubMed ID: 19422667
-
CD3zeta expression and T cell proliferation are inhibited by TGF-beta1 and IL-10 in cervical cancer patients.
Díaz-Benítez CE, Navarro-Fuentes KR, Flores-Sosa JA, Juárez-Díaz J, Uribe-Salas FJ, Román-Basaure E, González-Mena LE, Alonso de Ruíz P, López-Estrada G, Lagunas-Martínez A, Bermúdez-Morales VH, Alcocer-González JM, Martínez-Barnetche J, Hernández-Pando R, Rosenstein Y, Moreno J, Madrid-Marina V
J Clin Immunol. 2009
PubMed ID: 19259799
-
Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
Ehret GB, O'Connor AA, Weder A, Cooper RS, Chakravarti A
Eur J Hum Genet. 2009
PubMed ID: 19536175
-
Integrating receptor signal inputs that influence small Rho GTPase activation dynamics at the immunological synapse.
Makrogianneli K, Carlin LM, Keppler MD, Matthews DR, Ofo E, Coolen A, Ameer-Beg SM, Barber PR, Vojnovic B, Ng T
Mol Cell Biol. 2009
PubMed ID: 19307303
-
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
-
CD247 can bind SHC1, no matter if CD247 is phosphorylated.
Liu T, Chen F, Tang N, Feng J, Zhao D, Wei K, Zhu Y, He F, Liu S
J Mol Recognit. 2009
PubMed ID: 19229850
-
T cell CD3 receptor zeta (TCRzeta)-chain expression in children with idiopathic nephrotic syndrome.
Aviles DH, Vehaskari MV, Culotta KS, Manning J, Ochoa AC, Zea AH
Pediatr Nephrol. 2009
PubMed ID: 19082633
-
Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation.
Fernandez DR, Telarico T, Bonilla E, Li Q, Banerjee S, Middleton FA, Phillips PE, Crow MK, Oess S, Muller-Esterl W, Perl A
J Immunol. 2009
PubMed ID: 19201859
-
Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.
Cheung CL, Chan BY, Chan V, Ikegawa S, Kou I, Ngai H, Smith D, Luk KD, Huang QY, Mori S, Sham PC, Kung AW
Hum Mol Genet. 2009
PubMed ID: 19064610
-
CD3zeta down-modulation may explain Vgamma9Vdelta2 T lymphocyte anergy in HIV-infected patients.
Sacchi A, Tempestilli M, Turchi F, Agrati C, Casetti R, Cimini E, Gioia C, Martini F
J Infect Dis. 2009
PubMed ID: 19090773
-
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
-
Altered T and B lymphocyte signaling pathways in lupus.
Peng SL
Autoimmun Rev. 2009
PubMed ID: 18721908
-
Developing a novel model system to target insulin-reactive CD8 T cells.
Scott GS, Fishman S, Margalit A, Siew LK, Chapman S, Wen L, Gross G, Wong FS
Ann N Y Acad Sci. 2008
PubMed ID: 19120267
-
Expansion of T-cell receptor zeta dim effector T cells in acute coronary syndromes.
Ammirati E, Vermi AC, Cianflone D, Banfi M, Foglieni C, Godino C, Airoldi F, Ferri LA, Gorman CL, Manfredi AA, Maseri A, Cope AP, Monaco C
Arterioscler Thromb Vasc Biol. 2008
PubMed ID: 18787188
-
PP2A dephosphorylates Elf-1 and determines the expression of CD3zeta and FcRgamma in human systemic lupus erythematosus T cells.
Juang YT, Wang Y, Jiang G, Peng HB, Ergin S, Finnell M, Magilavy A, Kyttaris VC, Tsokos GC
J Immunol. 2008
PubMed ID: 18714041
-
Defect in TCR-CD3zeta signaling mediates T cell hypo-responsiveness in mesenteric lymph node.
Yi HJ, Lee CG, Kwon HK, So JS, Sahoo A, Hwang JS, Jash A, Hwang KC, Im SH
Mol Immunol. 2008
PubMed ID: 18619676
-
The RNA-stabilizing protein HuR regulates the expression of zeta chain of the human T cell receptor-associated CD3 complex.
Moulton VR, Kyttaris VC, Juang YT, Chowdhury B, Tsokos GC
J Biol Chem. 2008
PubMed ID: 18505733
-
Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity.
Holst J, Wang H, Eder KD, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K, Chruscinski A, Smeyne R, van Oers NS, Utz PJ, Vignali DA
Nat Immunol. 2008
PubMed ID: 18469818
-
The signaling adaptor protein CD3zeta is a negative regulator of dendrite development in young neurons.
Baudouin SJ, Angibaud J, Loussouarn G, Bonnamain V, Matsuura A, Kinebuchi M, Naveilhan P, Boudin H
Mol Biol Cell. 2008
PubMed ID: 18367546
-
CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells.
Perruche S, Zhang P, Liu Y, Saas P, Bluestone JA, Chen W
Nat Med. 2008
PubMed ID: 18438416
-
The extracellular part of zeta is buried in the T cell antigen receptor complex.
Minguet S, Swamy M, Dopfer EP, Dengler E, Alarcón B, Schamel WW
Immunol Lett. 2008
PubMed ID: 18215426
-
The short length of the extracellular domain of zeta is crucial for T cell antigen receptor function.
Minguet S, Swamy M, Schamel WW
Immunol Lett. 2008
PubMed ID: 18207249
-
Conservative sequences in 3'UTR of TCRzeta mRNA regulate TCRzeta in SLE T cells.
Tsuzaka K, Itami Y, Kumazawa C, Suzuki M, Setoyama Y, Yoshimoto K, Suzuki K, Abe T, Takeuchi T
Biochem Biophys Res Commun. 2008
PubMed ID: 18177736
-
The construction and in vitro testing of photo-activatable cancer targeting folated anti-CD3 conjugates.
Thompson S, Dessi J, Self CH
Biochem Biophys Res Commun. 2008
PubMed ID: 18068664
-
Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.
Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T
Rheumatology (Oxford). 2008
PubMed ID: 18174230
-
A common pathway mediated through Toll-like receptors leads to T- and natural killer-cell immunosuppression.
Vaknin I, Blinder L, Wang L, Gazit R, Shapira E, Genina O, Pines M, Pikarsky E, Baniyash M
Blood. 2008
PubMed ID: 17991807
-
Polymorphisms in the CD3Z gene influence TCRzeta expression in systemic lupus erythematosus patients and healthy controls.
Gorman CL, Russell AI, Zhang Z, Cunninghame Graham D, Cope AP, Vyse TJ
J Immunol. 2008
PubMed ID: 18178846
-
Chronic inflammation and CD16+ natural killer cell zeta-chain downregulation in hemodialysis patients.
Eleftheriadis T, Kartsios C, Yiannaki E, Kazila P, Antoniadi G, Liakopoulos V, Markala D
Blood Purif. 2008
PubMed ID: 18463433
-
Chronic inflammation and T cell zeta-chain downregulation in hemodialysis patients.
Eleftheriadis T, Kartsios C, Yiannaki E, Kazila P, Antoniadi G, Liakopoulos V, Markala D
Am J Nephrol. 2008
PubMed ID: 17951997
-
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
-
Differential expression of T-cell CD3-zeta chains in patients with cervical dysplasia before and after treatment.
Shondel SM, Helm CW, Gercel-Taylor C, Taylor DD
Int J Gynecol Cancer. 2007
PubMed ID: 17997796
-
B and T lymphocyte attenuator interacts with CD3zeta and inhibits tyrosine phosphorylation of TCRzeta complex during T-cell activation.
Wu TH, Zhen Y, Zeng C, Yi HF, Zhao Y
Immunol Cell Biol. 2007
PubMed ID: 17607320
-
Keeping the (kinase) party going: SLP-76 and ITK dance to the beat.
Qi Q, August A
Sci STKE. 2007
PubMed ID: 17652306
-
TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues.
Zhang Z, Gorman CL, Vermi AC, Monaco C, Foey A, Owen S, Amjadi P, Vallance A, McClinton C, Marelli-Berg F, Isomäki P, Russell A, Dazzi F, Vyse TJ, Brennan FM, Cope AP
Blood. 2007
PubMed ID: 17255353
-
CD99 activates T cells via a costimulatory function that promotes raft association of TCR complex and tyrosine phosphorylation of TCR zeta.
Oh KI, Kim BK, Ban YL, Choi EY, Jung KC, Lee IS, Park SH
Exp Mol Med. 2007
PubMed ID: 17464179
-
The constitutive tyrosine phosphorylation of CD3zeta results from TCR-MHC interactions that are independent of thymic selection.
Becker AM, DeFord-Watts LM, Wuelfing C, van Oers NS
J Immunol. 2007
PubMed ID: 17371967
-
FcRgamma chain does not replace CD3zeta chain in CD3zeta-deficient T lymphocytes of patients with gastric adenocarcinoma.
Lopez-Santalla M, Krishnan S, Valeri AP, Aguilera-Montilla N, Fisher CU, Perez-Blas M, Gutierrez-Calvo A, Lasa I, Granell-Vicent J, Tsokos GC, Martin-Villa JM
Mol Immunol. 2007
PubMed ID: 17134755
-
Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits.
Sigalov AB, Aivazian DA, Uversky VN, Stern LJ
Biochemistry. 2006
PubMed ID: 17176095
-
Structural disorder of the CD3zeta transmembrane domain studied with 2D IR spectroscopy and molecular dynamics simulations.
Mukherjee P, Kass I, Arkin IT, Zanni MT
J Phys Chem B. 2006
PubMed ID: 17134238
-
Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference.
Li CJ
J Cell Physiol. 2006
PubMed ID: 17001685
-
Decreased expression of CD3zeta and nuclear transcription factor kappa B in patients with pulmonary tuberculosis: potential mechanisms and reversibility with treatment.
Zea AH, Culotta KS, Ali J, Mason C, Park HJ, Zabaleta J, Garcia LF, Ochoa AC
J Infect Dis. 2006
PubMed ID: 17054067
-
The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor.
Call ME, Schnell JR, Xu C, Lutz RA, Chou JJ, Wucherpfennig KW
Cell. 2006
PubMed ID: 17055436
-
Identification of chromosome intervals from 129 and C57BL/6 mouse strains linked to the development of systemic lupus erythematosus.
Heidari Y, Bygrave AE, Rigby RJ, Rose KL, Walport MJ, Cook HT, Vyse TJ, Botto M
Genes Immun. 2006
PubMed ID: 16943797
-
Effect of TNF-alpha on CD3-zeta and MHC-I in postnatal rat hippocampus.
Sourial-Bassillious N, Eklöf AC, Scott L, Aperia A, Zelenin S
Pediatr Res. 2006
PubMed ID: 16940250
-
The DNA sequence and biological annotation of human chromosome 1.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E
Nature. 2006
PubMed ID: 16710414
-
Intratumor CD4 T-cell accumulation requires stronger priming than for expansion and lymphokine secretion.
Joncker NT, Helft J, Jacquet A, Premel V, Lantz O
Cancer Res. 2006
PubMed ID: 16707473
-
Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency.
Rieux-Laucat F, Hivroz C, Lim A, Mateo V, Pellier I, Selz F, Fischer A, Le Deist F
N Engl J Med. 2006
PubMed ID: 16672702
-
Identification of substrates of human protein-tyrosine phosphatase PTPN22.
Wu J, Katrekar A, Honigberg LA, Smith AM, Conn MT, Tang J, Jeffery D, Mortara K, Sampang J, Williams SR, Buggy J, Clark JM
J Biol Chem. 2006
PubMed ID: 16461343
-
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
-
Genetic dissection of vasculitis, myeloperoxidase-specific antineutrophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh mice.
Hamano Y, Tsukamoto K, Abe M, Sun GD, Zhang D, Fujii H, Matsuoka S, Tanaka M, Ishida-Okawara A, Tachikawa H, Nishimura H, Tokunaka K, Hirose S, Suzuki K
J Immunol. 2006
PubMed ID: 16517735
-
Multiplicity and plasticity of natural killer cell signaling pathways.
Chiesa S, Mingueneau M, Fuseri N, Malissen B, Raulet DH, Malissen M, Vivier E, Tomasello E
Blood. 2006
PubMed ID: 16291591
-
Type II phosphatidylinositol 4-kinase beta associates with TCR-CD3 zeta chain in Jurkat cells.
Srivastava R, Sinha RK, Subrahmanyam G
Mol Immunol. 2006
PubMed ID: 16337488
-
DNA microarray gene expression profile of T cells with the splice variants of TCRzeta mRNA observed in systemic lupus erythematosus.
Tsuzaka K, Nozaki K, Kumazawa C, Shiraishi K, Setoyama Y, Yoshimoto K, Suzuki K, Abe T, Takeuchi T
J Immunol. 2006
PubMed ID: 16393980
-
Modelling thymic HIV-1 Nef effects.
Stove V, Verhasselt B
Curr HIV Res. 2006
PubMed ID: 16454711
-
Defective CD3zeta chain expression in Herpesvirus saimiri (HVS)-derived T-cell lines in gastric adenocarcinoma.
Lopez-Santalla M, Krishnan S, Valeri AP, Aguilera-Montilla N, Fisher CU, Perez-Blas M, Gutierrez-Calvo A, Lasa I, Granell-Vicent J, Tsokos GC, Martin-Villa JM
Cell Immunol. 2005
PubMed ID: 16616055
-
The cyclic AMP response element modulator regulates transcription of the TCR zeta-chain.
Tenbrock K, Kyttaris VC, Ahlmann M, Ehrchen JM, Tolnay M, Melkonyan H, Mawrin C, Roth J, Sorg C, Juang YT, Tsokos GC
J Immunol. 2005
PubMed ID: 16237091
-
Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture.
Barco A, Patterson S, Alarcon JM, Gromova P, Mata-Roig M, Morozov A, Kandel ER
Neuron. 2005
PubMed ID: 16202713
-
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
-
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
-
Pathways participating in activation of mouse uterine natural killer cells during pregnancy.
Xie X, He H, Colonna M, Seya T, Takai T, Croy BA
Biol Reprod. 2005
PubMed ID: 15878887
-
Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.
Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, Watts JD, Hood L, Aebersold R
Nat Methods. 2005
PubMed ID: 16094384
-
Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication.
Münch J, Schindler M, Wildum S, Rücker E, Bailer N, Knoop V, Novembre FJ, Kirchhoff F
J Virol. 2005
PubMed ID: 16051847
-
T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.
Choudhuri K, Wiseman D, Brown MH, Gould K, van der Merwe PA
Nature. 2005
PubMed ID: 16049493
-
Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography.
Zheng H, Hu P, Quinn DF, Wang YK
Mol Cell Proteomics. 2005
PubMed ID: 15659558
-
Selective expression of the 21-kilodalton tyrosine-phosphorylated form of TCR zeta promotes the emergence of T cells with autoreactive potential.
Pitcher LA, Mathis MA, Subramanian S, Young JA, Wakeland EK, Love PE, van Oers NS
J Immunol. 2005
PubMed ID: 15879101
-
Decreased stability and translation of T cell receptor zeta mRNA with an alternatively spliced 3'-untranslated region contribute to zeta chain down-regulation in patients with systemic lupus erythematosus.
Chowdhury B, Tsokos CG, Krishnan S, Robertson J, Fisher CU, Warke RG, Warke VG, Nambiar MP, Tsokos GC
J Biol Chem. 2005
PubMed ID: 15743765
-
TCR signal strength influences alphabeta/gammadelta lineage fate.
Hayes SM, Li L, Love PE
Immunity. 2005
PubMed ID: 15894276
-
A splice variant of the TCR zeta mRNA lacking exon 7 leads to the down-regulation of TCR zeta, the TCR/CD3 complex, and IL-2 production in systemic lupus erythematosus T cells.
Tsuzaka K, Setoyama Y, Yoshimoto K, Shiraishi K, Suzuki K, Abe T, Takeuchi T
J Immunol. 2005
PubMed ID: 15749888
-
Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.
Nam HJ, Poy F, Saito H, Frederick CA
J Exp Med. 2005
PubMed ID: 15684325
-
Polarized development of memory cell-like IFN-gamma-producing cells in the absence of TCR zeta-chain.
Krymskaya L, Lee WH, Zhong L, Liu CP
J Immunol. 2005
PubMed ID: 15661872
-
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
-
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ
Nat Biotechnol. 2005
PubMed ID: 15592455
-
L-Arginine modulates CD3zeta expression and T cell function in activated human T lymphocytes.
Zea AH, Rodriguez PC, Culotta KS, Hernandez CP, DeSalvo J, Ochoa JB, Park HJ, Zabaleta J, Ochoa AC
Cell Immunol. 2004
PubMed ID: 15922712
-
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
Palacios EH, Weiss A
Oncogene. 2004
PubMed ID: 15489916
-
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
-
Lipid rafts mediate association of LFA-1 and CD3 and formation of the immunological synapse of CTL.
Marwali MR, MacLeod MA, Muzia DN, Takei F
J Immunol. 2004
PubMed ID: 15322154
-
Delayed and restricted expression limits putative instructional opportunities of Vgamma1.1/Vgamma2 gammadelta TCR in alphabeta/gammadelta lineage choice in the thymus.
Krotkova A, Smith E, Nerz G, Falk I, Eichmann K
J Immunol. 2004
PubMed ID: 15210755
-
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC
Anal Chem. 2004
PubMed ID: 15144186
-
CD28 signals in the immature immunological synapse.
Andres PG, Howland KC, Dresnek D, Edmondson S, Abbas AK, Krummel MF
J Immunol. 2004
PubMed ID: 15128767
-
CD3 zeta expression of regional lymph node and peripheral blood lymphocytes in gastric cancer.
Ishigami S, Natsugoe S, Miyazono F, Tokuda K, Nakajo A, Matsumoto M, Okumura H, Nakashima S, Hokita S, Maruyama I, Aikou T
Anticancer Res. 2004
PubMed ID: 15274412
-
HIV type 1 Nef increases the association of T cell receptor (TCR)-signaling molecules with T cell rafts and promotes activation-induced raft fusion.
Djordjevic JT, Schibeci SD, Stewart GJ, Williamson P
AIDS Res Hum Retroviruses. 2004
PubMed ID: 15186530
-
T cell killing does not require the formation of a stable mature immunological synapse.
Purbhoo MA, Irvine DJ, Huppa JB, Davis MM
Nat Immunol. 2004
PubMed ID: 15048111
-
HDAC6 deacetylase activity links the tubulin cytoskeleton with immune synapse organization.
Serrador JM, Cabrero JR, Sancho D, Mittelbrunn M, Urzainqui A, Sánchez-Madrid F
Immunity. 2004
PubMed ID: 15084271
-
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
-
Architectural changes in the TCR:CD3 complex induced by MHC:peptide ligation.
La Gruta NL, Liu H, Dilioglou S, Rhodes M, Wiest DL, Vignali DA
J Immunol. 2004
PubMed ID: 15004169
-
PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit.
Sozio MS, Mathis MA, Young JA, Wälchli S, Pitcher LA, Wrage PC, Bartók B, Campbell A, Watts JD, Aebersold R, Hooft van Huijsduijnen R, van Oers NS
J Biol Chem. 2004
PubMed ID: 14672952
-
Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif.
Sigalov A, Aivazian D, Stern L
Biochemistry. 2004
PubMed ID: 14967045
-
T cell receptor zeta reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor alpha.
Clark JM, Annenkov AE, Panesar M, Isomäki P, Chernajovsky Y, Cope AP
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14745016
-
Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.
Gorska MM, Stafford SJ, Cen O, Sur S, Alam R
J Exp Med. 2004
PubMed ID: 14757743
-
Immunosuppression in renal cancer: differential expression of signal transduction molecules in tumor-infiltrating, near-tumor tissue, and peripheral blood lymphocytes.
Riccobon A, Gunelli R, Ridolfi R, De Paola F, Flamini E, Fiori M, Saltutti C, Petrini M, Fiammenghi L, Stefanelli M, Granato AM, Cuzzocrea DE, Amadori D
Cancer Invest. 2004
PubMed ID: 15641485
-
The role of monocytes/macrophages in TCR-zeta chain downregulation and apoptosis of T lymphocytes in malignant pleural effusions.
Sikora J, Dworacki G, Giersz R, Zeromski J
J Biol Regul Homeost Agents. 2004
PubMed ID: 15323357
-
Decreased expression of the CD3zeta chain in T cells infiltrating the synovial membrane of patients with osteoarthritis.
Sakkas LI, Koussidis G, Avgerinos E, Gaughan J, Platsoucas CD
Clin Diagn Lab Immunol. 2004
PubMed ID: 14715568
-
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
-
CD38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD3-zeta subunit of the T cell antigen receptor.
Muñoz P, Navarro MD, Pavón EJ, Salmerón J, Malavasi F, Sancho J, Zubiaur M
J Biol Chem. 2003
PubMed ID: 14523017
-
Splice variant in TCRzeta links T cell receptor signaling to a G-protein-related signaling pathway.
Atkinson TP, Hall CG, Goldsmith J, Kirkham PM
Biochem Biophys Res Commun. 2003
PubMed ID: 14550268
-
Development of T cells expressing an altered TCR complex.
Lee WH, Ramos T, Krymskaya L, Liu CP
Eur J Immunol. 2003
PubMed ID: 14515253
-
Differential expression of TcR-CD3 zeta as evidence for altered immunoregulation in preeclamptic versus normotensive women.
Lam GK, Whitecar PW, Orton S, Boggess KA, Taylor DD
Am J Obstet Gynecol. 2003
PubMed ID: 14526327
-
TCR zeta mRNA with an alternatively spliced 3'-untranslated region detected in systemic lupus erythematosus patients leads to the down-regulation of TCR zeta and TCR/CD3 complex.
Tsuzaka K, Fukuhara I, Setoyama Y, Yoshimoto K, Suzuki K, Abe T, Takeuchi T
J Immunol. 2003
PubMed ID: 12928398
-
The CD43 coreceptor molecule recruits the zeta-chain as part of its signaling pathway.
Cruz-Muñoz ME, Salas-Vidal E, Salaiza-Suazo N, Becker I, Pedraza-Alva G, Rosenstein Y
J Immunol. 2003
PubMed ID: 12902492
-
Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus.
Nambiar MP, Fisher CU, Warke VG, Krishnan S, Mitchell JP, Delaney N, Tsokos GC
Arthritis Rheum. 2003
PubMed ID: 12847689
-
Investigation of the kinetics and order of tyrosine phosphorylation in the T-cell receptor zeta chain by the protein tyrosine kinase Lck.
Housden HR, Skipp PJ, Crump MP, Broadbridge RJ, Crabbe T, Perry MJ, Gore MG
Eur J Biochem. 2003
PubMed ID: 12755691
-
Selective cross-talk among natural cytotoxicity receptors in human natural killer cells.
Augugliaro R, Parolini S, Castriconi R, Marcenaro E, Cantoni C, Nanni M, Moretta L, Moretta A, Bottino C
Eur J Immunol. 2003
PubMed ID: 12731048
-
HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.
Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M
J Biosci. 2003
PubMed ID: 12734410
-
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12522270
-
Prevalence of T cell receptor zeta chain deficiency in systemic lupus erythematosus.
Nambiar MP, Mitchell JP, Ceruti RP, Malloy MA, Tsokos GC
Lupus. 2003
PubMed ID: 12587826
-
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
-
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
-
Regulation of constitutive TCR internalization by the zeta-chain.
D'Oro U, Munitic I, Chacko G, Karpova T, McNally J, Ashwell JD
J Immunol. 2002
PubMed ID: 12444133
-
Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus.
Juang YT, Tenbrock K, Nambiar MP, Gourley MF, Tsokos GC
J Immunol. 2002
PubMed ID: 12421992
-
Presentation of antagonist peptides to naive CD4+ T cells abrogates spatial reorganization of class II MHC peptide complexes on the surface of dendritic cells.
Chmielowski B, Pacholczyk R, Kraj P, Kisielow P, Ignatowicz L
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12411579
-
Absent or low expression of T-cell receptor zeta-chain in T cells infiltrating human pathological skin conditions.
Alaibac M, Pigozzi B, Saponeri A, Belloni-Fortina A, Peserico A
Arch Dermatol Res. 2002
PubMed ID: 12420108
-
Age-dependent defects in TCR-triggered cytoskeletal rearrangement in CD4+ T cells.
Garcia GG, Miller RA
J Immunol. 2002
PubMed ID: 12391217
-
Staging and resetting T cell activation in SMACs.
Freiberg BA, Kupfer H, Maslanik W, Delli J, Kappler J, Zaller DM, Kupfer A
Nat Immunol. 2002
PubMed ID: 12244310
-
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies.
Bunnell SC, Hong DI, Kardon JR, Yamazaki T, McGlade CJ, Barr VA, Samelson LE
J Cell Biol. 2002
PubMed ID: 12356870
-
DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription.
Nishihara H, Maeda M, Tsuda M, Makino Y, Sawa H, Nagashima K, Tanaka S
Biochem Biophys Res Commun. 2002
PubMed ID: 12176041
-
TCR/CD3 down-modulation and zeta degradation are regulated by ZAP-70.
Dumont C, Blanchard N, Di Bartolo V, Lezot N, Dufour E, Jauliac S, Hivroz C
J Immunol. 2002
PubMed ID: 12165490
-
Defective expression and tyrosine phosphorylation of the T cell receptor zeta chain in peripheral blood T cells from systemic lupus erythematosus patients.
Pang M, Setoyama Y, Tsuzaka K, Yoshimoto K, Amano K, Abe T, Takeuchi T
Clin Exp Immunol. 2002
PubMed ID: 12100036
-
Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation.
Gil D, Schamel WW, Montoya M, Sánchez-Madrid F, Alarcón B
Cell. 2002
PubMed ID: 12110186
-
Regulation of T cell receptor CD3zeta chain expression by L-arginine.
Rodriguez PC, Zea AH, Culotta KS, Zabaleta J, Ochoa JB, Ochoa AC
J Biol Chem. 2002
PubMed ID: 11950832
-
Reactive oxygen species differentially affect T cell receptor-signaling pathways.
Cemerski S, Cantagrel A, Van Meerwijk JP, Romagnoli P
J Biol Chem. 2002
PubMed ID: 11916964
-
A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling.
Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M
J Biol Chem. 2002
PubMed ID: 11891219
-
CD3-zetachain expression of intratumoral lymphocytes is closely related to survival in gastric carcinoma patients.
Ishigami S, Natsugoe S, Tokuda K, Nakajo A, Higashi H, Iwashige H, Aridome K, Hokita S, Aikou T
Cancer. 2002
PubMed ID: 11920499
-
Convergence of experimental, computational and evolutionary approaches predicts the presence of a tetrameric form for CD3-zeta.
Torres J, Briggs JA, Arkin IT
J Mol Biol. 2002
PubMed ID: 11851345
-
Oxidative stress is involved in the heat stress-induced downregulation of TCR zeta chain expression and TCR/CD3-mediated [Ca(2+)](i) response in human T-lymphocytes.
Nambiar MP, Fisher CU, Enyedy EJ, Warke VG, Kumar A, Tsokos GC
Cell Immunol. 2002
PubMed ID: 12202152
-
Adapters in lymphocyte signaling.
Leo A, Wienands J, Baier G, Horejsi V, Schraven B
J Clin Invest. 2002
PubMed ID: 11827988
-
Analysis of the individual role of the TCRzeta chain in transgenic mice after conditional activation with chemical inducers of dimerization.
Soldevila G, Castellanos C, Malissen M, Berg LJ
Cell Immunol. 2001
PubMed ID: 12088411
-
Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule.
Hombach A, Wieczarkowiecz A, Marquardt T, Heuser C, Usai L, Pohl C, Seliger B, Abken H
J Immunol. 2001
PubMed ID: 11714771
-
Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules.
Yamasaki S, Nishida K, Hibi M, Sakuma M, Shiina R, Takeuchi A, Ohnishi H, Hirano T, Saito T
J Biol Chem. 2001
PubMed ID: 11572860
-
A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells.
Fackler OT, Wolf D, Weber HO, Laffert B, D'Aloja P, Schuler-Thurner B, Geffin R, Saksela K, Geyer M, Peterlin BM, Schuler G, Baur AS
Curr Biol. 2001
PubMed ID: 11525746
-
Expression and selection of productively rearranged TCR beta VDJ genes are sequentially regulated by CD3 signaling in the development of NK1.1(+) alpha beta T cells.
Baur N, Nerz G, Nil A, Eichmann K
Int Immunol. 2001
PubMed ID: 11470773
-
Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70.
Wang HY, Altman Y, Fang D, Elly C, Dai Y, Shao Y, Liu YC
J Biol Chem. 2001
PubMed ID: 11353765
-
Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex.
Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H, Ohno H, Shirasawa T, Kuriyama T, O'Shea JJ, Saito T
J Biol Chem. 2001
PubMed ID: 11349123
-
Structure--function relationships in HIV-1 Nef.
Geyer M, Fackler OT, Peterlin BM
EMBO Rep. 2001
PubMed ID: 11463741
-
Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling.
Apasov SG, Blackburn MR, Kellems RE, Smith PT, Sitkovsky MV
J Clin Invest. 2001
PubMed ID: 11435465
-
The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.
Kirchgessner H, Dietrich J, Scherer J, Isomäki P, Korinek V, Hilgert I, Bruyns E, Leo A, Cope AP, Schraven B
J Exp Med. 2001
PubMed ID: 11390434
-
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
-
Negative regulation of expression and function of Fc gamma RIII by CD3 zeta in murine NK cells.
Arase H, Suenaga T, Arase N, Kimura Y, Ito K, Shiina R, Ohno H, Saito T
J Immunol. 2001
PubMed ID: 11123272
-
Functional requirement for class I MHC in CNS development and plasticity.
Huh GS, Boulanger LM, Du H, Riquelme PA, Brotz TM, Shatz CJ
Science. 2000
PubMed ID: 11118151
-
The quantity of TCR signal determines positive selection and lineage commitment of T cells.
Watanabe N, Arase H, Onodera M, Ohashi PS, Saito T
J Immunol. 2000
PubMed ID: 11086060
-
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
-
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
-
Development of dendritic epidermal T cells with a skewed diversity of gamma delta TCRs in V delta 1-deficient mice.
Hara H, Kishihara K, Matsuzaki G, Takimoto H, Tsukiyama T, Tigelaar RE, Nomoto K
J Immunol. 2000
PubMed ID: 11034374
-
The mechanism of phospholipase C-gamma1 regulation.
Kim MJ, Kim E, Ryu SH, Suh PG
Exp Mol Med. 2000
PubMed ID: 11048639
-
Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice.
Tomasello E, Desmoulins PO, Chemin K, Guia S, Cremer H, Ortaldo J, Love P, Kaiserlian D, Vivier E
Immunity. 2000
PubMed ID: 11021533
-
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
-
Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation.
Li Y, He X, Schembri-King J, Jakes S, Hayashi J
J Immunol. 2000
PubMed ID: 10799879
-
Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling.
Sosinowski T, Pandey A, Dixit VM, Weiss A
J Exp Med. 2000
PubMed ID: 10662792
-
Possible role of the plasminogen receptor as a site of interaction of the human immunodeficiency virus p24 immunosuppressive heptapeptide Ch7 with the host immune system.
Giacomini E, Chersi A, Giordani L, Luzzati AL
Scand J Immunol. 2000
PubMed ID: 10722370
-
SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling.
Tang J, Sawasdikosol S, Chang JH, Burakoff SJ
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10449770
-
The cytoplasmic tail of killer inhibitory receptor (KIR) associates with TCR zeta in a phosphorylation-dependent manner.
Cho HI, Park CG, Kim J
Immunol Lett. 1999
PubMed ID: 10424441
-
Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain.
Xu XN, Laffert B, Screaton GR, Kraft M, Wolf D, Kolanus W, Mongkolsapay J, McMichael AJ, Baur AS
J Exp Med. 1999
PubMed ID: 10224289
-
TCR kappa, a new splicing of the murine TCR zeta gene locus, is modulated by glucocorticoid treatment.
Giunchi L, Nocentini G, Ronchetti S, Bartoli A, Riccardi C, Migliorati G
Mol Cell Biochem. 1999
PubMed ID: 10395068
-
Generation of antigen-specific cytotoxic T lymphocytes and regulation of cytokine production takes place in the absence of CD3zeta.
She J, Ruzek MC, Velupillai P, de Aos I, Wang B, Harn DA, Sancho J, Biron CA, Terhorst C
Int Immunol. 1999
PubMed ID: 10330289
-
The bHLH gene Hes1 is essential for expansion of early T cell precursors.
Tomita K, Hattori M, Nakamura E, Nakanishi S, Minato N, Kageyama R
Genes Dev. 1999
PubMed ID: 10323870
-
Regulation of T cell receptor (TCR) beta gene expression by CD3 complex signaling in immature thymocytes: implications for TCRbeta allelic exclusion.
Biro J, Würch A, Potocnik AJ, Falk I, Mossmann H, Eichmann K
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10097132
-
Reduced generation but efficient TCR beta-chain selection of CD4+8+ double-positive thymocytes in mice with compromised CD3 complex signaling.
Würch A, Biro J, Falk I, Mossmann H, Eichmann K
J Immunol. 1999
PubMed ID: 10072519
-
Surface expression and functional competence of CD3-independent TCR zeta-chains in immature thymocytes.
Grassi F, Barbier E, Porcellini S, von Boehmer H, Cazenave PA
J Immunol. 1999
PubMed ID: 10072500
-
STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation.
Welte T, Leitenberg D, Dittel BN, al-Ramadi BK, Xie B, Chin YE, Janeway CA, Bothwell AL, Bottomly K, Fu XY
Science. 1999
PubMed ID: 9880255
-
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
-
Increased Zap-70 association with CD3zeta in CD4 T cells from old mice.
Garcia GG, Miller RA
Cell Immunol. 1998
PubMed ID: 9878110
-
Expression of a CD3 epsilon transgene in CD3 epsilon(null) mice does not restore CD3 gamma and delta expression but efficiently rescues T cell development from a subpopulation of prothymocytes.
Wang N, Wang B, Salio M, Allen D, She J, Terhorst C
Int Immunol. 1998
PubMed ID: 9885898
-
Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2.
Howe AY, Jung JU, Desrosiers RC
J Virol. 1998
PubMed ID: 9811718
-
Requirement of CD3 complex-associated signaling functions for expression of rearranged T cell receptor beta VDJ genes in early thymic development.
Würch A, Biro J, Potocnik AJ, Falk I, Mossmann H, Eichmann K
J Exp Med. 1998
PubMed ID: 9802979
-
Activation-induced apoptosis of mature T cells is dependent upon the level of surface TCR but not on the presence of the CD3 zeta ITAM.
She J, Matsui K, Terhorst C, Ju ST
Int Immunol. 1998
PubMed ID: 9846702
-
Increased PGE2 production mediates the in vitro inhibitory effect of the human immunodeficiency virus P24 immunosuppressive heptapeptide Ch7.
Giacomini E, Giordani L, di Modugno F, Chersi A, Luzzati AL
Scand J Immunol. 1998
PubMed ID: 9743208
-
T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane.
Bruyns E, Marie-Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, Autschbach F, Bensussan A, Meuer S, Schraven B
J Exp Med. 1998
PubMed ID: 9687533
-
Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation.
Kersh EN, Shaw AS, Allen PM
Science. 1998
PubMed ID: 9677202
-
NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis.
Vitale M, Bottino C, Sivori S, Sanseverino L, Castriconi R, Marcenaro E, Augugliaro R, Moretta L, Moretta A
J Exp Med. 1998
PubMed ID: 9625766
-
Physical and functional association between thymic shared antigen-1/stem cell antigen-2 and the T cell receptor complex.
Kosugi A, Saitoh S, Noda S, Miyake K, Yamashita Y, Kimoto M, Ogata M, Hamaoka T
J Biol Chem. 1998
PubMed ID: 9575182
-
T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma).
Shores EW, Ono M, Kawabe T, Sommers CL, Tran T, Lui K, Udey MC, Ravetch J, Love PE
J Exp Med. 1998
PubMed ID: 9529325
-
Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-kappaB factors.
Ott M, Lovett JL, Mueller L, Verdin E
J Immunol. 1998
PubMed ID: 9510190
-
Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.
Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE
Oncogene. 1998
PubMed ID: 9484780
-
Anti-transferrin receptor monoclonal antibody: a novel immunosuppressant.
Woodward JE, Bayer AL, Chavin KD, Boleza KA, Baliga P
Transplantation. 1998
PubMed ID: 9448136
-
The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci.
Ardouin L, Ismaili J, Malissen B, Malissen M
J Exp Med. 1998
PubMed ID: 9419216
-
Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model.
San José E, Sahuquillo AG, Bragado R, Alarcón B
Eur J Immunol. 1998
PubMed ID: 9485181
-
Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
Gene. 1997
PubMed ID: 9373149
-
Co-localization of Fyn with CD3 complex, CD45 or CD28 depends on different mechanisms.
zur Hausen JD, Burn P, Amrein KE
Eur J Immunol. 1997
PubMed ID: 9368621
-
A new 12-kilodalton dimer associated with pre-TCR complex and clonotype-independent CD3 complex on immature thymocytes.
Takase K, Wakizaka K, von Boehmer H, Wada I, Moriya H, Saito T
J Immunol. 1997
PubMed ID: 9218590
-
Fc epsilonRI gamma can support T cell development and function in mice lacking endogenous TCR zeta-chain.
Shores E, Flamand V, Tran T, Grinberg A, Kinet JP, Love PE
J Immunol. 1997
PubMed ID: 9200458
-
Short-term dexamethasone treatment modulates the expression of the murine TCR zeta gene locus.
Ronchetti S, Nocentini G, Giunchi L, Bartoli A, Moraca R, Riccardi C, Migliorati G
Cell Immunol. 1997
PubMed ID: 9225003
-
A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development.
Wiest DL, Ashe JM, Howcroft TK, Lee HM, Kemper DM, Negishi I, Singer DS, Singer A, Abe R
Immunity. 1997
PubMed ID: 9208839
-
Early alpha beta T cell development in the thymus of normal and genetically altered mice.
Fehling HJ, von Boehmer H
Curr Opin Immunol. 1997
PubMed ID: 9099797
-
Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway.
Ott M, Emiliani S, Van Lint C, Herbein G, Lovett J, Chirmule N, McCloskey T, Pahwa S, Verdin E
Science. 1997
PubMed ID: 9045614
-
Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire.
Shores EW, Tran T, Grinberg A, Sommers CL, Shen H, Love PE
J Exp Med. 1997
PubMed ID: 9120395
-
The single positive T cells found in CD3-zeta/eta-/- mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex.
Lin SY, Ardouin L, Gillet A, Malissen M, Malissen B
J Exp Med. 1997
PubMed ID: 9034149
-
Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2.
Raab M, da Silva AJ, Findell PR, Rudd CE
Immunity. 1997
PubMed ID: 9047237
-
Development and function of T cells in T cell antigen receptor/CD3 zeta knockout mice reconstituted with Fc epsilon RI gamma.
Liu CP, Lin WJ, Huang M, Kappler JW, Marrack P
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9012833
-
Differential interaction of the CD2 extracellular and intracellular domains with the tyrosine phosphatase CD45 and the zeta chain of the TCR/CD3/zeta complex.
Verhagen AM, Schraven B, Wild M, Wallich R, Meuer SC
Eur J Immunol. 1996
PubMed ID: 8977276
-
CSK associates with the TCR zeta and epsilon chains via its SH2 domain; a mechanism for turning off TCR signaling.
Catipović B
Lijec Vjesn. 1996
PubMed ID: 9172452
-
Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase.
Pani G, Fischer KD, Mlinaric-Rascan I, Siminovitch KA
J Exp Med. 1996
PubMed ID: 9064344
-
Interferon-gamma (IFN-gamma) can counteract the in vitro inhibitory effect of an HIV p24 immunosuppressive heptapeptide.
Luzzati AL, Boirivant M, Giacomini E, Giordani L, Di Modugno F, Chersi A
Clin Exp Immunol. 1996
PubMed ID: 8809126
-
Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.
Boussiotis VA, Barber DL, Lee BJ, Gribben JG, Freeman GJ, Nadler LM
J Exp Med. 1996
PubMed ID: 8760790
-
Localization of the antigen CD3, zeta polypeptide (CD3Z) to cattle chromosome 3q11-q14.
Amarante MR, Ansari HA, Maher DW, Pearce PD, Broad TE
Mamm Genome. 1996
PubMed ID: 8661744
-
Binding affinities of the SH2 domains of ZAP-70, p56lck and Shc to the zeta chain ITAMs of the T-cell receptor determined by surface plasmon resonance.
Labadia ME, Ingraham RH, Schembri-King J, Morelock MM, Jakes S
J Leukoc Biol. 1996
PubMed ID: 8656061
-
Expression of functional molecules by human CD3- decidual granular leucocyte clones.
Gudelj L, Deniz G, Rukavina D, Johnson PM, Christmas SE
Immunology. 1996
PubMed ID: 8675217
-
Anti-CD2 monoclonal antibody-induced receptor changes. II. Interaction of CD2 and CD3.
Lin J, Chavin KD, Qin L, Ding Y, Bromberg JS
Cell Immunol. 1996
PubMed ID: 8603434
-
Tyrosine-phosphorylated T cell receptor zeta chain associates with the actin cytoskeleton upon activation of mature T lymphocytes.
Rozdzial MM, Malissen B, Finkel TH
Immunity. 1995
PubMed ID: 7584152
-
Transcriptional regulation of the murine TCR zeta gene.
Wang L, Bronstein N, Hsu V, Baniyash M
Int Immunol. 1995
PubMed ID: 8562508
-
The role of tyrosine phosphorylation in the interaction of cellular tyrosine kinases with the T cell receptor zeta chain tyrosine-based activation motif.
Osman N, Lucas S, Cantrell D
Eur J Immunol. 1995
PubMed ID: 7589084
-
Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor.
Hatada MH, Lu X, Laird ER, Green J, Morgenstern JP, Lou M, Marr CS, Phillips TB, Ram MK, Theriault K
Nature. 1995
PubMed ID: 7659156
-
Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-alpha/beta+ T cells and expansion of NK1.1+ TCR-gamma/delta+ T cell development in CD3 zeta-deficient mice.
Arase H, Ono S, Arase N, Park SY, Wakizaka K, Watanabe H, Ohno H, Saito T
J Exp Med. 1995
PubMed ID: 7650493
-
Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
Zhou MM, Meadows RP, Logan TM, Yoon HS, Wade WS, Ravichandran KS, Burakoff SJ, Fesik SW
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7544002
-
Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR.
Nel AE, Gupta S, Lee L, Ledbetter JA, Kanner SB
J Biol Chem. 1995
PubMed ID: 7629168
-
Four loci from human chromosome 1 are physically assigned to sheep chromosome 1p.
Broad TE, Burkin DJ, Cambridge LM, Carpenter MA, Jones C
Mamm Genome. 1995
PubMed ID: 8589528
-
Regulation of thymocyte development through CD3: functional dissociation between p56lck and CD3 sigma in early thymic selection.
Levelt CN, Mombaerts P, Wang B, Kohler H, Tonegawa S, Eichmann K, Terhorst C
Immunity. 1995
PubMed ID: 7648394
-
Cell-surface-expressed T-cell antigen-receptor zeta chain is associated with the cytoskeleton.
Caplan S, Zeliger S, Wang L, Baniyash M
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7761399
-
T cell receptor iota an alternatively spliced product of the T cell receptor zeta gene.
Nocentini G, Ronchetti S, Bartoli A, Testa G, D'Adamio F, Riccardi C, Migliorati G
Eur J Immunol. 1995
PubMed ID: 7774644
-
High-resolution linkage map in the vicinity of the Lp locus.
Mullick A, Trasler D, Gros P
Genomics. 1995
PubMed ID: 7607671
-
Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase.
Mustelin T, Williams S, Tailor P, Couture C, Zenner G, Burn P, Ashwell JD, Altman A
Eur J Immunol. 1995
PubMed ID: 7737297
-
Molecular cloning of the rat CD3 zeta/eta/theta gene.
Matsuura A, Itoh Y, Kinebuchi M, Shen M, Hashimoto Y, Katabami S, Kikuchi K
Transplant Proc. 1995
PubMed ID: 7725394
-
Selection of peripheral and intestinal T lymphocytes lacking CD3 zeta.
Simpson S, Holländer G, She J, Levelt C, Huang M, Terhorst C
Int Immunol. 1995
PubMed ID: 7734423
-
The human OTF1 locus which overlaps the CD3Z gene is located at 1q22-->q23.
Sturm RA, Eyre HJ, Baker E, Sutherland GR
Cytogenet Cell Genet. 1995
PubMed ID: 7842742
-
ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity.
Isakov N, Wange RL, Burgess WH, Watts JD, Aebersold R, Samelson LE
J Exp Med. 1995
PubMed ID: 7528772
-
T cell development in CD3-zeta mutant mice.
Huang MT
Int Rev Immunol. 1995
PubMed ID: 7494107
-
Role of TCR zeta chain in T cell development and selection.
Shores EW, Huang K, Tran T, Lee E, Grinberg A, Love PE
Science. 1994
PubMed ID: 7526464
-
Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain.
Furukawa T, Itoh M, Krueger NX, Streuli M, Saito H
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7526385
-
Developmental regulation of the TCR zeta-chain. Differential expression and tyrosine phosphorylation of the TCR zeta-chain in resting immature and mature T lymphocytes.
Rozdzial MM, Kubo RT, Turner SL, Finkel TH
J Immunol. 1994
PubMed ID: 7519206
-
Double-negative thymocyte subsets in CD3 zeta chain-deficient mice: absence of HSA+CD44-CD25- cells.
Crompton T, Moore M, MacDonald HR, Malissen B
Eur J Immunol. 1994
PubMed ID: 7520000
-
An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex.
Luzzati AL, Giacomini E, Giordani L, Viora M, Chersi A, Camponeschi B, Pugliese O
Cell Immunol. 1994
PubMed ID: 7517794
-
Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif.
Gauen LK, Zhu Y, Letourneur F, Hu Q, Bolen JB, Matis LA, Klausner RD, Shaw AS
Mol Cell Biol. 1994
PubMed ID: 8196616
-
Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.
Chan AC, van Oers NS, Tran A, Turka L, Law CL, Ryan JC, Clark EA, Weiss A
J Immunol. 1994
PubMed ID: 8176201
-
Expression of the zeta protein subunit in CD3- NK effectors derived from human thymus.
Beecher MS, Baiocchi RA, Linett ML, Krajewski CA, Caligiuri MA
Cell Immunol. 1994
PubMed ID: 7514106
-
Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand.
Ohno H, Goto S, Taki S, Shirasawa T, Nakano H, Miyatake S, Aoe T, Ishida Y, Maeda H, Shirai T
EMBO J. 1994
PubMed ID: 8131747
-
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
PubMed ID: 8125298
-
Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.
Liu CP, Ueda R, She J, Sancho J, Wang B, Weddell G, Loring J, Kurahara C, Dudley EC, Hayday A
EMBO J. 1993
PubMed ID: 8223495
-
Structural analysis of the CD3 zeta/eta locus of the rat. Expression of zeta but not eta transcripts by rat T cells.
Itoh Y, Matsuura A, Kinebuchi M, Honda R, Takayama S, Ichimiya S, Kon S, Kikuchi K
J Immunol. 1993
PubMed ID: 8409430
-
The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]
Penninger JM, Neu N, Timms E, Wallace VA, Koh DR, Kishihara K, Pummerer C, Mak TW
J Exp Med. 1993
PubMed ID: 8228830
-
Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.
Ohno H, Aoe T, Taki S, Kitamura D, Ishida Y, Rajewsky K, Saito T
EMBO J. 1993
PubMed ID: 8223445
-
T cell development in mice lacking the CD3-zeta/eta gene.
Malissen M, Gillet A, Rocha B, Trucy J, Vivier E, Boyer C, Köntgen F, Brun N, Mazza G, Spanopoulou E
EMBO J. 1993
PubMed ID: 8223444
-
CD3 zeta/eta/theta locus is colinear with and transcribed antisense to the gene encoding the transcription factor Oct-1.
Lerner A, D'Adamio L, Diener AC, Clayton LK, Reinherz EL
J Immunol. 1993
PubMed ID: 8376772
-
Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells.
Wange RL, Malek SN, Desiderio S, Samelson LE
J Biol Chem. 1993
PubMed ID: 8366117
-
T cell development in mice that lack the zeta chain of the T cell antigen receptor complex.
Love PE, Shores EW, Johnson MD, Tremblay ML, Lee EJ, Grinberg A, Huang SP, Singer A, Westphal H
Science. 1993
PubMed ID: 7688481
-
Rat class III Fc gamma receptor isoforms differ in IgG subclass-binding specificity and fail to associate productively with rat CD3 zeta.
Farber DL, Giorda R, Nettleton MY, Trucco M, Kochan JP, Sears DW
J Immunol. 1993
PubMed ID: 8482840
-
Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms.
Waksman G, Shoelson SE, Pant N, Cowburn D, Kuriyan J
Cell. 1993
PubMed ID: 7680960
-
T cell antigen receptor-eta subunit. Low levels of expression and limited cross-species conservation.
Jensen JP, Cenciarelli C, Hou D, Rellahan BL, Dean M, Weissman AM
J Immunol. 1993
PubMed ID: 8417118
-
Differential regulation of T-cell receptor processing and surface expression affected by CD3 theta, an alternatively spliced product of the CD3 zeta/eta gene locus.
Clayton LK, Diener AC, Lerner A, Tse AG, Koyasu S, Reinherz EL
J Biol Chem. 1992
PubMed ID: 1464613
-
Engagement of the TcR/CD3 complex stimulates p59fyn(T) activity: detection of associated proteins at 72 and 120-130 kD.
da Silva AJ, Yamamoto M, Zalvan CH, Rudd CE
Mol Immunol. 1992
PubMed ID: 1454062
-
Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells.
Morse HC
J Immunol. 1992
PubMed ID: 1431091
-
Evidence for an association between the T cell receptor/CD3 antigen complex and the CD5 antigen in human T lymphocytes.
Osman N, Ley SC, Crumpton MJ
Eur J Immunol. 1992
PubMed ID: 1385158
-
Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXR alpha, RXR beta, and RXR gamma.
Hoopes CW, Taketo M, Ozato K, Liu Q, Howard TA, Linney E, Seldin MF
Genomics. 1992
PubMed ID: 1358808
-
Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA.
Oakey RJ, Watson ML, Seldin MF
Hum Mol Genet. 1992
PubMed ID: 1301170
-
Targeting of the T-cell receptor zeta-chain gene in embryonic stem cells: strategies for generating multiple mutations in a single gene.
Love PE, Tremblay ML, Westphal H
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1409721
-
Five novel antigens illustrate shared phenotype between mouse thymic stromal cells, thymocytes, and peripheral lymphocytes.
Tucek CL, Godfrey DI, Boyd RL
Int Immunol. 1992
PubMed ID: 1390434
-
The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope.
Luzzati AL, Giacomini E, Giordani L, Pugliese O, Viora M, Chersi A
Immunol Lett. 1992
PubMed ID: 1385321
-
Human genomic sequences corresponding to murine CD3 eta-related transcripts: lack of conservation or expression of homologous human products.
Lerner A, Diener AC, Reinherz EL, Clayton LK
Eur J Immunol. 1992
PubMed ID: 1322304
-
Organization of the human T cell receptor zeta/eta gene and its genetic linkage to the Fc gamma RII-Fc gamma RIII gene cluster.
Jensen JP, Hou D, Ramsburg M, Taylor A, Dean M, Weissman AM
J Immunol. 1992
PubMed ID: 1532817
-
Purification and initial characterization of the lymphocyte-specific protein-tyrosyl kinase p56lck from a baculovirus expression system.
Watts JD, Wilson GM, Ettenhadieh E, Clark-Lewis I, Kubanek CA, Astell CR, Marth JD, Aebersold R
J Biol Chem. 1992
PubMed ID: 1730679
-
Protein tyrosine kinase p59fyn is associated with the T cell receptor-CD3 complex in functional human lymphocytes.
Gassmann M, Guttinger M, Amrein KE, Burn P
Eur J Immunol. 1992
PubMed ID: 1530920
-
The T cell antigen receptor tyrosine kinase pathway.
Samelson LE, Egerton M, Thomas PM, Wange RL
Adv Exp Med Biol. 1992
PubMed ID: 1485569
-
1F7 (CD26): a marker of thymic maturation involved in the differential regulation of the CD3 and CD2 pathways of human thymocyte activation.
Dang NH, Torimoto Y, Shimamura K, Tanaka T, Daley JF, Schlossman SF, Morimoto C
J Immunol. 1991
PubMed ID: 1717577
-
CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development.
Clayton LK, D'Adamio L, Howard FD, Sieh M, Hussey RE, Koyasu S, Reinherz EL
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1828894
-
Human natural killer cells and mature T lymphocytes express identical CD3 zeta subunits as defined by cDNA cloning and sequence analysis.
Moingeon P, Stebbins CC, D'Adamio L, Lucich J, Reinherz EL
Eur J Immunol. 1990
PubMed ID: 2145165
-
Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1.
Watson ML, Kingsmore SF, Johnston GI, Siegelman MH, Le Beau MM, Lemons RS, Bora NS, Howard TA, Weissman IL, McEver RP
J Exp Med. 1990
PubMed ID: 1694218
-
Molecular cloning of the CD3 eta subunit identifies a CD3 zeta-related product in thymus-derived cells.
Jin YJ, Clayton LK, Howard FD, Koyasu S, Sieh M, Steinbrich R, Tarr GE, Reinherz EL
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2139725
-
Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells.
Anderson P, Caligiuri M, O'Brien C, Manley T, Ritz J, Schlossman SF
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2138330
-
The implications of subunit interactions for the structure of the T cell receptor-CD3 complex.
Koning F, Maloy WL, Coligan JE
Eur J Immunol. 1990
PubMed ID: 2138083
-
CD3 zeta and eta chains are produced by alternative splicing from a common gene.
Ohno H, Saito T
Int Immunol. 1990
PubMed ID: 2150596
-
Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV.
Luzzati AL, Pugliese O, Giacomini E, Giordani L, Quintieri F, Hraba T, Mach O, Krchnák V, Vágner J
Folia Biol (Praha). 1990
PubMed ID: 2111780
-
Gene mapping of the three subunits of the high affinity FcR for IgE to mouse chromosomes 1 and 19.
Hupp K, Siwarski D, Mock BA, Kinet JP
J Immunol. 1989
PubMed ID: 2531187
-
Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1.
Moseley WS, Seldin MF
Genomics. 1989
PubMed ID: 2574151
-
The isolation and characterization of the murine T cell antigen receptor zeta chain gene.
Baniyash M, Hsu VW, Seldin MF, Klausner RD
J Biol Chem. 1989
PubMed ID: 2787796
-
The mouse CD3-gamma, -delta, and -epsilon genes reside within 50 kilobases on chromosome 9, whereas CD3-zeta maps to chromosome 1, band H.
Letourneur F, Mattei MG, Malissen B
Immunogenetics. 1989
PubMed ID: 2522910
-
Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex.
Weissman AM, Hou D, Orloff DG, Modi WS, Seuanez H, O'Brien SJ, Klausner RD
Proc Natl Acad Sci U S A. 1988
PubMed ID: 2974162
-
T cell CD3-zeta eta heterodimer expression and coupling to phosphoinositide hydrolysis.
Merćep M, Bonifacino JS, Garcia-Morales P, Samelson LE, Klausner RD, Ashwell JD
Science. 1988
PubMed ID: 2845582
-
Molecular cloning of the zeta chain of the T cell antigen receptor.
Weissman AM, Baniyash M, Hou D, Samelson LE, Burgess WH, Klausner RD
Science. 1988
PubMed ID: 3278377
-
Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family.
Gold DP, Clevers H, Alarcon B, Dunlap S, Novotny J, Williams AF, Terhorst C
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3478717
-
A new subunit of the human T-cell antigen receptor complex.
Weissman AM, Samelson LE, Klausner RD
Nature. 1986
PubMed ID: 3785426
Model Organism Phenotype Links
|
Relevant resources: