IL1RL1

Summary from T1DBase Top Help

Gene Description:

interleukin 1 receptor-like 1

Synonyms:

MGC32623, T1, T1/ST2, FIT1, Fit-1, FIT-1, St2-rs1, IL33R, St2, Ly84, IL1RL1, Il1rl1, DER4, ST2, ST2L, ST2V

Orthologs:

Human IL1RL1 (protein-coding), Mouse Il1rl1 (protein-coding), Rat Il1rl1 (protein-coding)

Sources

Gene Overview from T1DBase Top Help

(Human) GRCh37 - chr2:102927962..102968497 (40.53 kb) View in Genome Browser

(Mouse) NCBIM37 - chr1:40486415..40522260 (35.84 kb) View in Genome Browser

(Rat) RGSC3.4 - chr9:39577879..39624781 (46.90 kb) View in Genome Browser

Beta Cell Gene Atlas from T1DBase Top Help

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression Top Help

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

HaemAtlas Expression Top Help

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker	EB	MK	CD66b	CD14	CD19	CD8	CD4	CD56
Expression Pattern									HaemAtlasProfile

Expression Legend

Interactions from T1DBase Top Help

Interactions Table for IL1RL1:

The IL1RL1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
IL1RL1	TMED1	HPRD	empirical	8621446
IL1RL1	TIRAP	HPRD	empirical	15004556
IL1RL1	IL1RAP	IntAct	empirical	17675517
IL1RL1	IRAK1	IntAct	empirical	10854325
IL1RL1	MYD88	HPRD, IntAct	empirical	15004556 10854325 16286016
IL1RL1	IRAK4	IntAct	empirical	16286016
IL1RL1	TOLLIP	IntAct	empirical	10854325
IL1RL1	TRAF6	IntAct	empirical	16286016
IL1RL1	IL33	HPRD, IntAct	empirical	16286016 17675517

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 22

Publications Top Help

Type 1 Diabetes Publications: 2

Publications: 156

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.
Chang YJ, Kim HY, Albacker LA, Baumgarth N, McKenzie AN, Smith DE, Dekruyff RH, Umetsu DT
Nat Immunol. 2011
PubMed ID: 21623379
ST2 deletion enhances innate and acquired immunity to murine mammary carcinoma.
Jovanovic I, Radosavljevic G, Mitrovic M, Juranic VL, McKenzie AN, Arsenijevic N, Jonjic S, Lukic ML
Eur J Immunol. 2011
PubMed ID: 21484786
IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss.
Zaiss MM, Kurowska-Stolarska M, Böhm C, Gary R, Scholtysek C, Stolarski B, Reilly J, Kerr S, Millar NL, Kamradt T, McInnes IB, Fallon PG, David JP, Liew FY, Schett G
J Immunol. 2011
PubMed ID: 21515798
Prognostic utility of ST2 in patients with acute dyspnea and preserved left ventricular ejection fraction.
Shah KB, Kop WJ, Christenson RH, Diercks DB, Henderson S, Hanson K, Li SY, deFilippi CR
Clin Chem. 2011
PubMed ID: 21515743
Loss of suppression of tumorigenicity 2 (ST2) gene reverses sepsis-induced inhibition of lung host defense in mice.
Hoogerwerf JJ, Leendertse M, Wieland CW, de Vos AF, de Boer JD, Florquin S, van der Poll T
Am J Respir Crit Care Med. 2011
PubMed ID: 20959556
Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood.
Savenije OE, Kerkhof M, Reijmerink NE, Brunekreef B, de Jongste JC, Smit HA, Wijga AH, Postma DS, Koppelman GH
J Allergy Clin Immunol. 2011
PubMed ID: 21281963
IL-33 is expressed in human osteoblasts, but has no direct effect on bone remodeling.
Saidi S, Bouri F, Lencel P, Duplomb L, Baud'huin M, Delplace S, Leterme D, Miellot F, Heymann D, Hardouin P, Palmer G, Magne D
Cytokine. 2011
PubMed ID: 21190867
High-sensitivity ST2 for prediction of adverse outcomes in chronic heart failure.
Ky B, French B, McCloskey K, Rame JE, McIntosh E, Shahi P, Dries DL, Tang WH, Wu AH, Fang JC, Boxer R, Sweitzer NK, Levy WC, Goldberg LR, Jessup M, Cappola TP
Circ Heart Fail. 2011
PubMed ID: 21178018
IL-33 activates B1 cells and exacerbates contact sensitivity.
Komai-Koma M, Gilchrist DS, McKenzie AN, Goodyear CS, Xu D, Liew FY
J Immunol. 2011
PubMed ID: 21239718
Mast cells as sensors of cell injury through IL-33 recognition.
Enoksson M, Lyberg K, Möller-Westerberg C, Fallon PG, Nilsson G, Lunderius-Andersson C
J Immunol. 2011
PubMed ID: 21239713
Expression and effects of IL-33 and ST2 in allergic bronchial asthma: IL-33 induces eotaxin production in lung fibroblasts.
Kurokawa M, Matsukura S, Kawaguchi M, Ieki K, Suzuki S, Odaka M, Watanabe S, Homma T, Sato M, Yamaguchi M, Takeuchi H, Adachi M
Int Arch Allergy Immunol. 2011
PubMed ID: 21646790
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Investigation of genetic susceptibility factors for human longevity - A targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A
Mutat Res. 2010
PubMed ID: 20800603
Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.
Ferreira MA, McRae AF, Medland SE, Nyholt DR, Gordon SD, Wright MJ, Henders AK, Madden PA, Visscher PM, Wray NR, Heath AC, Montgomery GW, Duffy DL, Martin NG
Eur J Hum Genet. 2010
PubMed ID: 21150878
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, D'Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panés J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D'Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M
Nat Genet. 2010
PubMed ID: 21102463
Interleukin family member ST2 and mortality in acute dyspnoea.
Socrates T, deFilippi C, Reichlin T, Twerenbold R, Breidhardt T, Noveanu M, Potocki M, Reiter M, Arenja N, Heinisch C, Meissner J, Jaeger C, Christenson R, Mueller C
J Intern Med. 2010
PubMed ID: 20804518
Genetic variability of the distal promoter of the ST2 gene is associated with angiographic severity of coronary artery disease.
Tsapaki A, Zaravinos A, Apostolakis S, Voudris K, Vogiatzi K, Kochiadakis GE, Spandidos DA
J Thromb Thrombolysis. 2010
PubMed ID: 20602249
A large-scale, consortium-based genomewide association study of asthma.
Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M, Cookson WO, GABRIEL Consortium
N Engl J Med. 2010
PubMed ID: 20860503
IL-33 exacerbates eosinophil-mediated airway inflammation.
Stolarski B, Kurowska-Stolarska M, Kewin P, Xu D, Liew FY
J Immunol. 2010
PubMed ID: 20693421
Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice.
Miller AM, Asquith DL, Hueber AJ, Anderson LA, Holmes WM, McKenzie AN, Xu D, Sattar N, McInnes IB, Liew FY
Circ Res. 2010
PubMed ID: 20634488
Analyses of shared genetic factors between asthma and obesity in children.
Melén E, Himes BE, Brehm JM, Boutaoui N, Klanderman BJ, Sylvia JS, Lasky-Su J
J Allergy Clin Immunol. 2010
PubMed ID: 20816195
Characterization of ST2 transgenic mice with resistance to IL-33.
Ohto-Ozaki H, Kuroiwa K, Mato N, Matsuyama Y, Hayakawa M, Tamemoto H, Tominaga S
Eur J Immunol. 2010
PubMed ID: 20662097
Primary sources and immunological prerequisites for sST2 secretion in humans.
Mildner M, Storka A, Lichtenauer M, Mlitz V, Ghannadan M, Hoetzenecker K, Nickl S, Dome B, Tschachler E, Ankersmit HJ
Cardiovasc Res. 2010
PubMed ID: 20363761
IL-33 reduces macrophage foam cell formation.
McLaren JE, Michael DR, Salter RC, Ashlin TG, Calder CJ, Miller AM, Liew FY, Ramji DP
J Immunol. 2010
PubMed ID: 20543107
Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1).
Kaieda S, Shin K, Nigrovic PA, Seki K, Lee RT, Stevens RL, Lee DM
J Biol Chem. 2010
PubMed ID: 20427273
Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection.
Alves-Filho JC, Sônego F, Souto FO, Freitas A, Verri WA, Auxiliadora-Martins M, Basile-Filho A, McKenzie AN, Xu D, Cunha FQ, Liew FY
Nat Med. 2010
PubMed ID: 20473304
Allergy and glioma risk: Test of association by genotype.
Dobbins SE, Hosking FJ, Shete S, Armstrong G, Swerdlow A, Liu Y, Yu R, Lau C, Schoemaker MJ, Hepworth SJ, Muir K, Bondy M, Houlston RS
Int J Cancer. 2010
PubMed ID: 20503266
ST2 negatively regulates TLR2 signaling, but is not required for bacterial lipoprotein-induced tolerance.
Liu J, Buckley JM, Redmond HP, Wang JH
J Immunol. 2010
PubMed ID: 20400705
ST2 and mortality in non-ST-segment elevation acute coronary syndrome.
Eggers KM, Armstrong PW, Califf RM, Simoons ML, Venge P, Wallentin L, James SK
Am Heart J. 2010
PubMed ID: 20435187
Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL, Thio CL
J Infect Dis. 2010
PubMed ID: 20331378
Genetic evidence for a role of IL33 in nasal polyposis.
Buysschaert ID, Grulois V, Eloy P, Jorissen M, Rombaux P, Bertrand B, Collet S, Bobic S, Vlaminck S, Hellings PW, Lambrechts D
Allergy. 2010
PubMed ID: 19860791
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.
Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TK, Bucks C, Kane CM, Fallon PG, Pannell R, Jolin HE, McKenzie AN
Nature. 2010
PubMed ID: 20200518
Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis.
Pastorelli L, Garg RR, Hoang SB, Spina L, Mattioli B, Scarpa M, Fiocchi C, Vecchi M, Pizarro TT
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20385815
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
Multiple common variants for celiac disease influencing immune gene expression.
Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Adány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek WH, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA
Nat Genet. 2010
PubMed ID: 20190752
IL-33 exacerbates autoantibody-induced arthritis.
Xu D, Jiang HR, Li Y, Pushparaj PN, Kurowska-Stolarska M, Leung BP, Mu R, Tay HK, McKenzie AN, McInnes IB, Melendez AJ, Liew FY
J Immunol. 2010
PubMed ID: 20139274
Levels of soluble ST2 in serum associated with severity of dengue due to tumour necrosis factor alpha stimulation.
Houghton-Triviño N, Salgado DM, Rodríguez JA, Bosch I, Castellanos JE
J Gen Virol. 2010
PubMed ID: 19889931
IL-33 induces IL-13-dependent cutaneous fibrosis.
Rankin AL, Mumm JB, Murphy E, Turner S, Yu N, McClanahan TK, Bourne PA, Pierce RH, Kastelein R, Pflanz S
J Immunol. 2010
PubMed ID: 20042577
IL-33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondii.
Jones LA, Roberts F, Nickdel MB, Brombacher F, McKenzie AN, Henriquez FL, Alexander J, Roberts CW
Eur J Immunol. 2010
PubMed ID: 19950183
Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans.
Wu H, Romieu I, Shi M, Hancock DB, Li H, Sienra-Monge JJ, Chiu GY, Xu H, del Rio-Navarro BE, London SJ
J Allergy Clin Immunol. 2010
PubMed ID: 19910030
ST2 gene expression is proliferation-dependent and its ligand, IL-33, induces inflammatory reaction in endothelial cells.
Aoki S, Hayakawa M, Ozaki H, Takezako N, Obata H, Ibaraki N, Tsuru T, Tominaga S, Yanagisawa K
Mol Cell Biochem. 2010
PubMed ID: 19756962
IL-33 is produced by mast cells and regulates IgE-dependent inflammation.
Hsu CL, Neilsen CV, Bryce PJ
PLoS One. 2010
PubMed ID: 20689814
Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis.
Plager DA, Kahl JC, Asmann YW, Nilson AE, Pallanch JF, Friedman O, Kita H
PLoS One. 2010
PubMed ID: 20625511
Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.
Näkki A, Kouhia ST, Saarela J, Harilainen A, Tallroth K, Videman T, Battié MC, Kaprio J, Peltonen L, Kujala UM
BMC Med Genet. 2010
PubMed ID: 20353565
Identification and functionality of proteomes secreted by rat cardiac stem cells and neonatal cardiomyocytes.
Stastna M, Chimenti I, Marbán E, Van Eyk JE
Proteomics. 2010
PubMed ID: 20014349
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW, Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P, YEAR Consortium, Altshuler D, Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA, Worthington J, Klareskog L, Gregersen PK, Daly MJ, Plenge RM
Nat Genet. 2009
PubMed ID: 19898481
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation.
Kurowska-Stolarska M, Stolarski B, Kewin P, Murphy G, Corrigan CJ, Ying S, Pitman N, Mirchandani A, Rana B, van Rooijen N, Shepherd M, McSharry C, McInnes IB, Xu D, Liew FY
J Immunol. 2009
PubMed ID: 19841166
Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling.
Seki K, Sanada S, Kudinova AY, Steinhauser ML, Handa V, Gannon J, Lee RT
Circ Heart Fail. 2009
PubMed ID: 19919994
Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production.
Choi YS, Choi HJ, Min JK, Pyun BJ, Maeng YS, Park H, Kim J, Kim YM, Kwon YG
Blood. 2009
PubMed ID: 19661270
Potential role of soluble ST2 protein in idiopathic nephrotic syndrome recurrence following kidney transplantation.
Bruneau S, Le Berre L, Hervé C, Valanciuté A, Kamal M, Naulet J, Tesson L, Foucher Y, Soulillou JP, Sahali D, Dantal J
Am J Kidney Dis. 2009
PubMed ID: 19520469
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells.
Guo L, Wei G, Zhu J, Liao W, Leonard WJ, Zhao K, Paul W
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19666510
IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex.
Espinassous Q, Garcia-de-Paco E, Garcia-Verdugo I, Synguelakis M, von Aulock S, Sallenave JM, McKenzie AN, Kanellopoulos J
J Immunol. 2009
PubMed ID: 19553541
Evidence of association of interleukin-1 receptor-like 1 gene polymorphisms with chronic rhinosinusitis.
Castano R, Bossé Y, Endam LM, Desrosiers M
Am J Rhinol Allergy. 2009
PubMed ID: 19671251
The cytokine interleukin-33 mediates anaphylactic shock.
Pushparaj PN, Tay HK, H'ng SC, Pitman N, Xu D, McKenzie A, Liew FY, Melendez AJ
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19506243
Analyses of associations with asthma in four asthma population samples from Canada and Australia.
Daley D, Lemire M, Akhabir L, Chan-Yeung M, He JQ, McDonald T, Sandford A, Stefanowicz D, Tripp B, Zamar D, Bosse Y, Ferretti V, Montpetit A, Tessier MC, Becker A, Kozyrskyj AL, Beilby J, McCaskie PA, Musk B, Warrington N, James A, Laprise C, Palmer LJ, Paré PD, Hudson TJ
Hum Genet. 2009
PubMed ID: 19247692
Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway.
Kearley J, Buckland KF, Mathie SA, Lloyd CM
Am J Respir Crit Care Med. 2009
PubMed ID: 19179489
Investigations into the role of ST2 in acute asthma in children.
Ali M, Zhang G, Thomas WR, McLean CJ, Bizzintino JA, Laing IA, Martin AC, Goldblatt J, Le Souëf PN, Hayden CM
Tissue Antigens. 2009
PubMed ID: 19254249
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, Thorleifsson G, Helgadottir H, Steinthorsdottir V, Stefansson H, Williams C, Hui J, Beilby J, Warrington NM, James A, Palmer LJ, Koppelman GH, Heinzmann A, Krueger M, Boezen HM, Wheatley A, Altmuller J, Shin HD, Uh ST, Cheong HS, Jonsdottir B, Gislason D, Park CS, Rasmussen LM, Porsbjerg C, Hansen JW, Backer V, Werge T, Janson C, Jönsson UB, Ng MC, Chan J, So WY, Ma R, Shah SH, Granger CB, Quyyumi AA, Levey AI, Vaccarino V, Reilly MP, Rader DJ, Williams MJ, van Rij AM, Jones GT, Trabetti E, Malerba G, Pignatti PF, Boner A, Pescollderungg L, Girelli D, Olivieri O, Martinelli N, Ludviksson BR, Ludviksdottir D, Eyjolfsson GI, Arnar D, Thorgeirsson G, Deichmann K, Thompson PJ, Wjst M, Hall IP, Postma DS, Gislason T, Gulcher J, Kong A, Jonsdottir I, Thorsteinsdottir U, Stefansson K
Nat Genet. 2009
PubMed ID: 19198610
Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing.
Videman T, Saarela J, Kaprio J, Näkki A, Levälahti E, Gill K, Peltonen L, Battié MC
Arthritis Rheum. 2009
PubMed ID: 19180518
Secretion of soluble ST2 - possible explanation for systemic immunosuppression after heart surgery.
Szerafin T, Niederpold T, Mangold A, Hoetzenecker K, Hacker S, Roth G, Lichtenauer M, Dworschak M, Wolner E, Ankersmit HJ
Thorac Cardiovasc Surg. 2009
PubMed ID: 19169993
Increased soluble serum markers caspase-cleaved cytokeratin-18, histones, and ST2 indicate apoptotic turnover and chronic immune response in COPD.
Hacker S, Lambers C, Pollreisz A, Hoetzenecker K, Lichtenauer M, Mangold A, Niederpold T, Hacker A, Lang G, Dworschak M, Vukovich T, Gerner C, Klepetko W, Ankersmit HJ
J Clin Lab Anal. 2009
PubMed ID: 19927353
Asthma and genes encoding components of the vitamin D pathway.
Bossé Y, Lemire M, Poon AH, Daley D, He JQ, Sandford A, White JH, James AL, Musk AW, Palmer LJ, Raby BA, Weiss ST, Kozyrskyj AL, Becker A, Hudson TJ, Laprise C
Respir Res. 2009
PubMed ID: 19852851
Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Enjuanes A, Benavente Y, Bosch F, Martín-Guerrero I, Colomer D, Pérez-Alvarez S, Reina O, Ardanaz MT, Jares P, García-Orad A, Pujana MA, Montserrat E, de Sanjosé S, Campo E
Cancer Res. 2008
PubMed ID: 19074885
Serial sampling of ST2 predicts 90-day mortality following destabilized heart failure.
Boisot S, Beede J, Isakson S, Chiu A, Clopton P, Januzzi J, Maisel AS, Fitzgerald RL
J Card Fail. 2008
PubMed ID: 18995177
An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor.
Suzukawa M, Iikura M, Koketsu R, Nagase H, Tamura C, Komiya A, Nakae S, Matsushima K, Ohta K, Yamamoto K, Yamaguchi M
J Immunol. 2008
PubMed ID: 18941187
Characteristics of the novel interleukin family biomarker ST2 in patients with acute heart failure.
Rehman SU, Mueller T, Januzzi JL
J Am Coll Cardiol. 2008
PubMed ID: 19017513
The IL-33/ST2 pathway: therapeutic target and novel biomarker.
Kakkar R, Lee RT
Nat Rev Drug Discov. 2008
PubMed ID: 18827826
IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4.
Kurowska-Stolarska M, Kewin P, Murphy G, Russo RC, Stolarski B, Garcia CC, Komai-Koma M, Pitman N, Li Y, Niedbala W, McKenzie AN, Teixeira MM, Liew FY, Xu D
J Immunol. 2008
PubMed ID: 18802081
Soluble ST2 plasma concentrations predict 1-year mortality in acutely dyspneic emergency department patients with pulmonary disease.
Martinez-Rumayor A, Camargo CA, Green SM, Baggish AL, O'Donoghue M, Januzzi JL
Am J Clin Pathol. 2008
PubMed ID: 18794051
Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy.
Reijmerink NE, Postma DS, Bruinenberg M, Nolte IM, Meyers DA, Bleecker ER, Koppelman GH
J Allergy Clin Immunol. 2008
PubMed ID: 18774397
IL-33 exacerbates antigen-induced arthritis by activating mast cells.
Xu D, Jiang HR, Kewin P, Li Y, Mu R, Fraser AR, Pitman N, Kurowska-Stolarska M, McKenzie AN, McInnes IB, Liew FY
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18667700
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Am J Physiol Endocrinol Metab. 2008
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The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33.
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Cytokine. 2008
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Int Immunol. 2008
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Clin Chem. 2008
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Mol Cell Proteomics. 2008
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J Exp Med. 2008
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Cytokine. 2008
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Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation.
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J Biol Chem. 2007
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IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex.
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J Immunol. 2007
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J Leukoc Biol. 2007
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IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system.
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J Clin Invest. 2007
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Eur J Immunol. 2007
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Biochem Biophys Res Commun. 2006
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Nucleic Acids Res. 2006
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Immunity. 2005
PubMed ID: 16286016
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Hum Mol Genet. 2005
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Science. 2005
PubMed ID: 16141073
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Science. 2005
PubMed ID: 16141072
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Nature. 2005
PubMed ID: 15815621
Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62.
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J Immunol. 2005
PubMed ID: 15611251
From ORFeome to biology: a functional genomics pipeline.
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Genome Res. 2004
PubMed ID: 15489336
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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Genome Res. 2004
PubMed ID: 15489334
Signal peptide prediction based on analysis of experimentally verified cleavage sites.
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Protein Sci. 2004
PubMed ID: 15340161
A functional polymorphism in the interleukin-1 receptor-1 gene is associated with increased risk of Helicobacter pylori infection but not with gastric cancer.
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Dig Dis Sci. 2004
PubMed ID: 15481335
Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and trauma.
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Intensive Care Med. 2004
PubMed ID: 14991091
Genetic variations in humans associated with differences in the course of hepatitis C.
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Biochem Biophys Res Commun. 2004
PubMed ID: 15063762
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
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Genome Res. 2004
PubMed ID: 15060019
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammation.
Ma Y, Liu H, Tu-Rapp H, Thiesen HJ, Ibrahim SM, Cole SM, Pope RM
Nat Immunol. 2004
PubMed ID: 15004557
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance.
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Nat Immunol. 2004
PubMed ID: 15004556
An unappreciated role for RNA surveillance.
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Genome Biol. 2004
PubMed ID: 14759258
Complete sequencing and characterization of 21,243 full-length human cDNAs.
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Nat Genet. 2004
PubMed ID: 14702039
Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons.
Bithell A, Alberta J, Hornby F, Stiles CD, Williams BP
Brain Res Dev Brain Res. 2003
PubMed ID: 14643017
The increase in serum soluble ST2 protein upon acute exacerbation of idiopathic pulmonary fibrosis.
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Chest. 2003
PubMed ID: 14555548
Stat5 expression is critical for mast cell development and survival.
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Blood. 2003
PubMed ID: 12714518
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
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Nat Biotechnol. 2003
PubMed ID: 12665801
Signaling through the T1/ST2 molecule is not necessary for Th2 differentiation but is important for the regulation of type 1 responses in nonhealing Leishmania major infection.
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Infect Immun. 2003
PubMed ID: 12654814
Identification of serum soluble ST2 receptor as a novel heart failure biomarker.
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Circulation. 2003
PubMed ID: 12578875
The effect of ST2 gene product on anchorage-independent growth of a glioblastoma cell line, T98G.
Haga Y, Yanagisawa K, Ohto-Ozaki H, Tominaga S, Masuzawa T, Iwahana H
Eur J Biochem. 2003
PubMed ID: 12492487
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction.
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J Biol Chem. 2002
PubMed ID: 12368275
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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Nature. 2002
PubMed ID: 12466851
ST2 protein induced by inflammatory stimuli can modulate acute lung inflammation.
Oshikawa K, Yanagisawa K, Tominaga S, Sugiyama Y
Biochem Biophys Res Commun. 2002
PubMed ID: 12435383
Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface.
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Eur J Immunol. 2002
PubMed ID: 12355452
Inhibition of proliferation and expression of T1 and cyclin D1 genes by thyroid hormone in mammary epithelial cells.
González-Sancho JM, Figueroa A, López-Barahona M, López E, Beug H, Muñoz A
Mol Carcinog. 2002
PubMed ID: 12112320
Influence of the IL-1Ra gene polymorphism on in vivo synthesis of IL-1Ra and IL-1beta after live yellow fever vaccination.
Hacker UT, Erhardt S, Tschöp K, Jelinek T, Endres S
Clin Exp Immunol. 2001
PubMed ID: 11531955
Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V.
Tago K, Noda T, Hayakawa M, Iwahana H, Yanagisawa K, Yashiro T, Tominaga S
Biochem Biophys Res Commun. 2001
PubMed ID: 11478810
Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation.
Oshikawa K, Kuroiwa K, Tago K, Iwahana H, Yanagisawa K, Ohno S, Tominaga SI, Sugiyama Y
Am J Respir Crit Care Med. 2001
PubMed ID: 11463601
A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression.
Sweet MJ, Leung BP, Kang D, Sogaard M, Schulz K, Trajkovic V, Campbell CC, Xu D, Liew FY
J Immunol. 2001
PubMed ID: 11359817
Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology.
Walzl G, Matthews S, Kendall S, Gutierrez-Ramos JC, Coyle AJ, Openshaw PJ, Hussell T
J Exp Med. 2001
PubMed ID: 11283151
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
DNA cloning using in vitro site-specific recombination.
Hartley JL, Temple GF, Brasch MA
Genome Res. 2000
PubMed ID: 11076863
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
The cloning and nucleotide sequence of human ST2L cDNA.
Li H, Tago K, Io K, Kuroiwa K, Arai T, Iwahana H, Tominaga S, Yanagisawa K
Genomics. 2000
PubMed ID: 10936050
T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis.
Senn KA, McCoy KD, Maloy KJ, Stark G, Fröhli E, Rülicke T, Klemenz R
Eur J Immunol. 2000
PubMed ID: 10940882
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F
Nat Cell Biol. 2000
PubMed ID: 10854325
T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses.
Townsend MJ, Fallon PG, Matthews DJ, Jolin HE, McKenzie AN
J Exp Med. 2000
PubMed ID: 10727469
The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function.
Hoshino K, Kashiwamura S, Kuribayashi K, Kodama T, Tsujimura T, Nakanishi K, Matsuyama T, Takeda K, Akira S
J Exp Med. 1999
PubMed ID: 10562328
Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM.
Tominaga S, Kuroiwa K, Tago K, Iwahana H, Yanagisawa K, Komatsu N
Biochem Biophys Res Commun. 1999
PubMed ID: 10527832
Different promoter usage and multiple transcription initiation sites of the interleukin-1 receptor-related human ST2 gene in UT-7 and TM12 cells.
Iwahana H, Yanagisawa K, Ito-Kosaka A, Kuroiwa K, Tago K, Komatsu N, Katashima R, Itakura M, Tominaga S
Eur J Biochem. 1999
PubMed ID: 10491084
Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.
Dale M, Nicklin MJ
Genomics. 1999
PubMed ID: 10191101
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors.
Moritz DR, Rodewald HR, Gheyselinck J, Klemenz R
J Immunol. 1998
PubMed ID: 9794420
Divergent effects of LPS on expression of IL-1 receptor family members in mononuclear phagocytes in vitro and in vivo.
Saccani S, Polentarutti N, Penton-Rol G, Sims JE, Mantovani A
Cytokine. 1998
PubMed ID: 9811530
T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function.
Löhning M, Stroehmann A, Coyle AJ, Grogan JL, Lin S, Gutierrez-Ramos JC, Levinson D, Radbruch A, Kamradt T
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9618516
Isolation of genes identified in mouse renal proximal tubule by comparing different gene expression profiles.
Takenaka M, Imai E, Kaneko T, Ito T, Moriyama T, Yamauchi A, Hori M, Kawamoto S, Okubo K
Kidney Int. 1998
PubMed ID: 9507200
Expression of ST2, an interleukin-1 receptor homologue, is induced by proinflammatory stimuli.
Kumar S, Tzimas MN, Griswold DE, Young PR
Biochem Biophys Res Commun. 1997
PubMed ID: 9207179
The expression of ST2 gene in helper T cells and the binding of ST2 protein to myeloma-derived RPMI8226 cells.
Yanagisawa K, Naito Y, Kuroiwa K, Arai T, Furukawa Y, Tomizuka H, Miura Y, Kasahara T, Tetsuka T, Tominaga S
J Biochem. 1997
PubMed ID: 9058198
Assignment of the human ST2 gene to chromosome 2 at q11.2.
Tominaga S, Inazawa J, Tsuji S
Hum Genet. 1996
PubMed ID: 8655130
Cloning of a putative ligand for the T1/ST2 receptor.
Gayle MA, Slack JL, Bonnert TP, Renshaw BR, Sonoda G, Taguchi T, Testa JR, Dower SK, Sims JE
J Biol Chem. 1996
PubMed ID: 8621446
ST2/T1 protein functionally binds to two secreted proteins from Balb/c 3T3 and human umbilical vein endothelial cells but does not bind interleukin 1.
Kumar S, Minnich MD, Young PR
J Biol Chem. 1995
PubMed ID: 7499265
Secreted and membrane-bound isoforms of T1, an orphan receptor related to IL-1-binding proteins, are differently expressed in vivo.
Rössler U, Thomassen E, Hültner L, Baier S, Danescu J, Werenskiold AK
Dev Biol. 1995
PubMed ID: 7883081
Growth factor-mediated induction of the delayed early gene T1 depends on a 12-O-tetradecanoylphorbol 13-acetate-responsive element located 3.6 kb upstream of the transcription initiation site.
Trüb T, Kalousek MB, Fröhli E, Klemenz R
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8171009
Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor.
Bergers G, Reikerstorfer A, Braselmann S, Graninger P, Busslinger M
EMBO J. 1994
PubMed ID: 8131748
Identification of the product of the murine ST2 gene.
Takagi T, Yanagisawa K, Tsukamoto T, Tetsuka T, Nagata S, Tominaga S
Biochim Biophys Acta. 1993
PubMed ID: 8347678
Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1.
Yanagisawa K, Takagi T, Tsukamoto T, Tetsuka T, Tominaga S
FEBS Lett. 1993
PubMed ID: 7916701
Nucleotide sequence of a complementary DNA for human ST2.
Tominaga S, Yokota T, Yanagisawa K, Tsukamoto T, Takagi T, Tetsuka T
Biochim Biophys Acta. 1992
PubMed ID: 1482686
Growth factor-induced delayed early response genes.
Lanahan A, Williams JB, Sanders LK, Nathans D
Mol Cell Biol. 1992
PubMed ID: 1508193
Murine ST2 gene is a member of the primary response gene family induced by growth factors.
Yanagisawa K, Tsukamoto T, Takagi T, Tominaga S
FEBS Lett. 1992
PubMed ID: 1587353
A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.
McMahan CJ, Slack JL, Mosley B, Cosman D, Lupton SD, Brunton LL, Grubin CE, Wignall JM, Jenkins NA, Brannan CI
EMBO J. 1991
PubMed ID: 1833184
Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping.
Tominaga S, Jenkins NA, Gilbert DJ, Copeland NG, Tetsuka T
Biochim Biophys Acta. 1991
PubMed ID: 1832015
A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor.
Tominaga S
FEBS Lett. 1989
PubMed ID: 2532153
Serum- and oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen.
Klemenz R, Hoffmann S, Werenskiold AK
Proc Natl Acad Sci U S A. 1989
PubMed ID: 2527364

Model Organism Phenotype Links Top Help

This section provides links to model organism phenotype resources. Currently only to mouse phenotypes.

Organism	Phenotype	Resources
Mouse	MGI:98427	IKMC

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	9173	17082	25556
EnsEMBL Gene(s)	ENSG00000115602	ENSMUSG00000026069	ENSRNOG00000014835
Unigene	Hs.66	Mm.289824	Rn.10072
Homologene	IL1RL1	Il1rl1	Il1rl1
OMIM	601203	N/A	N/A
GeneCards	IL1RL1	N/A	N/A
Beta Cell Genomics	DT.100767329 DT.113041 DT.92421864	DT.101365331 DT.101723639 DT.55100927	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	ENSP00000233954	N/A	N/A
MGI	N/A	MGI:98427	N/A
WikiGenes	9173	17082	25556

External resources (dkCOIN) from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

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