CD3E

Summary Top Help

Gene Description:

CD3 molecule, epsilon; CD3e molecule, epsilon (CD3-TCR complex); CD3 antigen, epsilon polypeptide

Synonyms:

T3e, T3E, CD3E, CD3epsilon, CD3, TCRE, Cd3e, AI504783

Orthologs:

Human CD3E (protein-coding), Mouse Cd3e (protein-coding), Rat Cd3e (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd2	Mouse	chr9:32308040..98698811	66.39	764	6 no lod score

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:118175260..118186890 (11.63 kb) View in Genome Browser

(Mouse) NCBIM37 - chr9:44806826..44817673 (10.85 kb) View in Genome Browser

(Rat) RGSC3.4 - chr8:47947257..47958419 (11.16 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CD3E:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CD3E:

The CD3E interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
CD3E	CD3EAP	HPRD	empirical	10373416
CD3E	EPS8	MINT	empirical	17617578
CD3E	PTPN22	HPRD, IntAct	empirical	16461343
CD3E	JAK3	BioGRID	empirical	11349123
CD3E	LCK	HPRD, BioGRID	empirical	11855827
CD3E	NCK1	HPRD, MINT, BioGRID	empirical	12110186 17617578 18955169
CD3E	NCL	HPRD, BioGRID	empirical	11115514
CD3E	TRAT1	HPRD	empirical	9687533
CD3E	PIK3R1	HPRD, BioGRID	empirical	11855827 11689561 9312149
CD3E	EPS8L1	MINT	empirical	17617578 18644376
CD3E	SHC1	HPRD, BioGRID	empirical	11855827
CD3E	EPS8L2	MINT	empirical	17617578
CD3E	SYK	HPRD, BioGRID	empirical	7761456
CD3E	TOP2B	HPRD, BioGRID	empirical	8626450
CD3E	ZAP70	HPRD, BioGRID	empirical	11855827 8366117 7761456
CD3E	EPS8L3	MINT	empirical	17617578
CD3E	NCK2	HPRD, MINT, BioGRID	empirical	12110186 17617578
CD3E	UNC119	HPRD	empirical	14757743
CD3E	CD3D	HPRD, IntAct, Reactome	empirical	9582308 9485181 20890284
CD3E	CD3G	HPRD, IntAct, BioGRID, Reactome	empirical	2138083 20890284 9582308
CD3E	CD79B	HPRD	empirical	7541024

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 5

Biocarta: 14

Reactome: 8

NCI-Nature Pathway Interaction Database: 7

Gene Ontology: 37

Publications from PubMed Top Help

Type 1 Diabetes Publications: 4

Publications: 277

Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes.
Kumar R, Ferez M, Swamy M, Arechaga I, Rejas MT, Valpuesta JM, Schamel WW, Alarcon B, van Santen HM
Immunity. 2011
PubMed ID: 21903423
Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax.
Kanady JD, Dellinger MT, Munger SJ, Witte MH, Simon AM
Dev Biol. 2011
PubMed ID: 21515254
Lack of cystic fibrosis transmembrane conductance regulator in CD3+ lymphocytes leads to aberrant cytokine secretion and hyperinflammatory adaptive immune responses.
Mueller C, Braag SA, Keeler A, Hodges C, Drumm M, Flotte TR
Am J Respir Cell Mol Biol. 2011
PubMed ID: 20724552
The expression pattern of CD3 chain genes in fetal/maternal interface.
Lu X, Chen S, Yang L, Zha X, Yang X, Li Y
Hematology. 2011
PubMed ID: 21669059
Change in expression pattern of TCR-CD3 complex in patients with multiple myeloma.
Li Y, Chen S, Yang L, Chen S, Lin C, Wang L, Lu Y, Geng S, Du X, Schmidt CA
Hematology. 2011
PubMed ID: 21669053
The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells.
Cretney E, Xin A, Shi W, Minnich M, Masson F, Miasari M, Belz GT, Smyth GK, Busslinger M, Nutt SL, Kallies A
Nat Immunol. 2011
PubMed ID: 21378976
Basal and antigen-induced exposure of the proline-rich sequence in CD3ε.
de la Cruz J, Kruger T, Parks CA, Silge RL, van Oers NS, Luescher IF, Schrum AG, Gil D
J Immunol. 2011
PubMed ID: 21228347
Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells.
Lochner M, Ohnmacht C, Presley L, Bruhns P, Si-Tahar M, Sawa S, Eberl G
J Exp Med. 2011
PubMed ID: 21173107
The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.
Hathcock KS, Farrington L, Ivanova I, Livak F, Selimyan R, Sen R, Williams J, Tai X, Hodes RJ
PLoS One. 2011
PubMed ID: 21673984
T cells contribute to tumor progression by favoring pro-tumoral properties of intra-tumoral myeloid cells in a mouse model for spontaneous melanoma.
Lengagne R, Pommier A, Caron J, Douguet L, Garcette M, Kato M, Avril MF, Abastado JP, Bercovici N, Lucas B, Prévost-Blondel A
PLoS One. 2011
PubMed ID: 21633700
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Cutting edge: Thymic NK cells develop independently from T cell precursors.
Ribeiro VS, Hasan M, Wilson A, Boucontet L, Pereira P, Lesjean-Pottier S, Satoh-Takayama N, Di Santo JP, Vosshenrich CA
J Immunol. 2010
PubMed ID: 20889548
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Polymorphisms of the T cell receptor CD3delta and CD3epsilon chains affect anti-CD3 antibody binding and T cell activation.
Boding L, Nielsen MW, Bonefeld CM, von Essen MR, Nielsen BL, Lauritsen JP, Hansen AK, Nielsen MM, Kongsbak M, Rubin M, Vennegaard MT, Odum N, Geisler C
Mol Immunol. 2010
PubMed ID: 20638133
MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output.
O'Connell RM, Chaudhuri AA, Rao DS, Gibson WS, Balazs AB, Baltimore D
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20660734
Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.
Tremblay M, Tremblay CS, Herblot S, Aplan PD, Hébert J, Perreault C, Hoang T
Genes Dev. 2010
PubMed ID: 20516195
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.
Berger M, Krebs P, Crozat K, Li X, Croker BA, Siggs OM, Popkin D, Du X, Lawson BR, Theofilopoulos AN, Xia Y, Khovananth K, Y Moresco EM, Satoh T, Takeuchi O, Akira S, Beutler B
Nat Immunol. 2010
PubMed ID: 20190759
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism.
Zotos D, Coquet JM, Zhang Y, Light A, D'Costa K, Kallies A, Corcoran LM, Godfrey DI, Toellner KM, Smyth MJ, Nutt SL, Tarlinton DM
J Exp Med. 2010
PubMed ID: 20142430
Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice.
Ohigashi I, Yamasaki Y, Hirashima T, Takahama Y
PLoS One. 2010
PubMed ID: 21203507
Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination.
Bremer J, O'Connor T, Tiberi C, Rehrauer H, Weis J, Aguzzi A
PLoS One. 2010
PubMed ID: 20805985
Selective preservation of bone marrow mature recirculating but not marginal zone B cells in murine models of chronic inflammation.
Traggiai E, Casati A, Frascoli M, Porcellini S, Ponzoni M, Sanvito F, Leng L, Bucala R, Moretta L, Grassi F
PLoS One. 2010
PubMed ID: 20582316
Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study.
Brophy K, Ryan AW, Turner G, Trimble V, Patel KD, O'Morain C, Kennedy NP, Egan B, Close E, Lawlor G, MacMathuna P, Stevens FM, Abuzakouk M, Feighery C, Kelleher D, McManus R
BMC Med Genet. 2010
PubMed ID: 20478055
A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling.
Wang Y, Becker D, Vass T, White J, Marrack P, Kappler JW
PLoS Biol. 2009
PubMed ID: 19956738
Expression of fully assembled TCR-CD3 complex on double positive thymocytes: synergistic role for the PRS and ER retention motifs in the intra-cytoplasmic tail of CD3epsilon.
Brodeur JF, Li S, Damlaj O, Dave VP
Int Immunol. 2009
PubMed ID: 19819936
Dynamics of CD3gammaepsilon and CD3deltaepsilon dimer expression during murine T cell development.
Laird RM, Hayes SM
Mol Immunol. 2009
PubMed ID: 19819020
The thymus-independent immunity conferred by a pneumococcal polysaccharide is mediated by long-lived plasma cells.
Taillardet M, Haffar G, Mondière P, Asensio MJ, Gheit H, Burdin N, Defrance T, Genestier L
Blood. 2009
PubMed ID: 19767510
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
In vitro preparation and characterization of the human CD3 epsilon epsilon homodimer and CD3 epsilon gamma and CD3 epsilon delta heterodimers.
Su Z, Wang H, Wan Y, Bi Z
Int J Mol Med. 2009
PubMed ID: 19724882
Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells.
Chen L, Sham CW, Chan AM, Francisco LM, Wu Y, Mareninov S, Sharpe AH, Freeman GJ, Yang XJ, Braun J, Gordon LK
Invest Ophthalmol Vis Sci. 2009
PubMed ID: 19420345
N-terminal negatively charged residues in CD3varepsilon chains as a phylogenetically conserved trait potentially yielding isoforms with different isoelectric points: analysis of human CD3varepsilon chains.
Bello R, Feito MJ, Ojeda G, Portolés P, Rojo JM
Immunol Lett. 2009
PubMed ID: 19616027
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.
Mingueneau M, Roncagalli R, Grégoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B
Immunity. 2009
PubMed ID: 19682930
The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions.
Deford-Watts LM, Tassin TC, Becker AM, Medeiros JJ, Albanesi JP, Love PE, Wülfing C, van Oers NS
J Immunol. 2009
PubMed ID: 19542373
TAp63 prevents premature aging by promoting adult stem cell maintenance.
Su X, Paris M, Gi YJ, Tsai KY, Cho MS, Lin YL, Biernaskie JA, Sinha S, Prives C, Pevny LH, Miller FD, Flores ER
Cell Stem Cell. 2009
PubMed ID: 19570515
Critical and multiple roles for the CD3epsilon intracytoplasmic tail in double negative to double positive thymocyte differentiation.
Brodeur JF, Li S, Martins Mda S, Larose L, Dave VP
J Immunol. 2009
PubMed ID: 19342663
Cutting Edge: Ikaros null thymocytes mature into the CD4 lineage with reduced TCR signal: A study using CD3{zeta} immunoreceptor tyrosine-based activation motif transgenic mice.
Urban JA, Brugmann W, Winandy S
J Immunol. 2009
PubMed ID: 19299690
Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches.
Tsuji M, Komatsu N, Kawamoto S, Suzuki K, Kanagawa O, Honjo T, Hori S, Fagarasan S
Science. 2009
PubMed ID: 19286559
Stepwise development of MAIT cells in mouse and human.
Martin E, Treiner E, Duban L, Guerri L, Laude H, Toly C, Premel V, Devys A, Moura IC, Tilloy F, Cherif S, Vera G, Latour S, Soudais C, Lantz O
PLoS Biol. 2009
PubMed ID: 19278296
Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity.
Komatsu N, Mariotti-Ferrandiz ME, Wang Y, Malissen B, Waldmann H, Hori S
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19174509
Essential role for Bclaf1 in lung development and immune system function.
McPherson JP, Sarras H, Lemmers B, Tamblyn L, Migon E, Matysiak-Zablocki E, Hakem A, Azami SA, Cardoso R, Fish J, Sanchez O, Post M, Hakem R
Cell Death Differ. 2009
PubMed ID: 19008920
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilon.
Martínez-Martín N, Risueño RM, Morreale A, Zaldívar I, Fernández-Arenas E, Herranz F, Ortiz AR, Alarcón B
Sci Signal. 2009
PubMed ID: 19671929
TCR-beta chains derived from peripheral gammadelta T cells can take part in alphabeta T-cell development.
Bosco N, Engdahl C, Bénard A, Rolink J, Ceredig R, Rolink AG
Eur J Immunol. 2008
PubMed ID: 18991270
Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis.
Jin J, Desai BN, Navarro B, Donovan A, Andrews NC, Clapham DE
Science. 2008
PubMed ID: 18974357
CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming.
Martín-Fontecha A, Baumjohann D, Guarda G, Reboldi A, Hons M, Lanzavecchia A, Sallusto F
J Exp Med. 2008
PubMed ID: 18838544
New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity.
Tinkle CL, Pasolli HA, Stokes N, Fuchs E
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18809908
The quality of chimpanzee T-cell activation and simian immunodeficiency virus/human immunodeficiency virus susceptibility achieved via antibody-mediated T-cell receptor/CD3 stimulation is a function of the anti-CD3 antibody isotype.
Bibollet-Ruche F, McKinney BA, Duverger A, Wagner FH, Ansari AA, Kutsch O
J Virol. 2008
PubMed ID: 18667496
Lymphocytes support oval cell-dependent liver regeneration.
Strick-Marchand H, Masse GX, Weiss MC, Di Santo JP
J Immunol. 2008
PubMed ID: 18684967
Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity.
Takeuchi K, Yang H, Ng E, Park SY, Sun ZY, Reinherz EL, Wagner G
J Mol Biol. 2008
PubMed ID: 18555270
Functional tolerance of CD8+ T cells induced by muscle-specific antigen expression.
Calbo S, Delagrèverie H, Arnoult C, Authier FJ, Tron F, Boyer O
J Immunol. 2008
PubMed ID: 18566407
CD4 help regulates expression of crucial genes involved in CD8 T cell memory and sensitivity to regulatory elements.
Rapetti L, Meunier S, Pontoux C, Tanchot C
J Immunol. 2008
PubMed ID: 18566395
The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling.
Tailor P, Tsai S, Shameli A, Serra P, Wang J, Robbins S, Nagata M, Szymczak-Workman AL, Vignali DA, Santamaria P
J Immunol. 2008
PubMed ID: 18566390
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia.
Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S, Augustin HG, Gattone VH, Folkman J, Strauss JF, Kalluri R
Nature. 2008
PubMed ID: 18469803
Regulatory CD4+ T cells are crucial for preventing CD8+ T cell-mediated autoimmunity.
Poitrasson-Rivière M, Bienvenu B, Le Campion A, Bécourt C, Martin B, Lucas B
J Immunol. 2008
PubMed ID: 18490729
Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity.
Holst J, Wang H, Eder KD, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K, Chruscinski A, Smeyne R, van Oers NS, Utz PJ, Vignali DA
Nat Immunol. 2008
PubMed ID: 18469818
Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response.
Wong ML, Dong C, Maestre-Mesa J, Licinio J
Mol Psychiatry. 2008
PubMed ID: 18504423
The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes.
Mingueneau M, Sansoni A, Grégoire C, Roncagalli R, Aguado E, Weiss A, Malissen M, Malissen B
Nat Immunol. 2008
PubMed ID: 18408722
Lung carcinomas do not induce T-cell apoptosis via the Fas/Fas ligand pathway but down-regulate CD3 epsilon expression.
Prado-Garcia H, Aguilar-Cazares D, Meneses-Flores M, Morales-Fuentes J, Lopez-Gonzalez JS
Cancer Immunol Immunother. 2008
PubMed ID: 17668204
Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells.
Wang Y, Kissenpfennig A, Mingueneau M, Richelme S, Perrin P, Chevrier S, Genton C, Lucas B, DiSanto JP, Acha-Orbea H, Malissen B, Malissen M
J Immunol. 2008
PubMed ID: 18209052
Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier.
Sevilla LM, Nachat R, Groot KR, Klement JF, Uitto J, Djian P, Määttä A, Watt FM
J Cell Biol. 2007
PubMed ID: 18166659
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.
Michie AM, Chan AC, Ciofani M, Carleton M, Lefebvre JM, He Y, Allman DM, Wiest DL, Zúñiga-Pflücker JC, Izon DJ
Int Immunol. 2007
PubMed ID: 17981791
Importance of T cells, gamma interferon, and tumor necrosis factor in immune control of the rapid grower Mycobacterium abscessus in C57BL/6 mice.
Rottman M, Catherinot E, Hochedez P, Emile JF, Casanova JL, Gaillard JL, Soudais C
Infect Immun. 2007
PubMed ID: 17875636
Deletion of the LIME adaptor protein minimally affects T and B cell development and function.
Grégoire C, Simova S, Wang Y, Sansoni A, Richelme S, Schmidt-Giese A, Simeoni L, Angelisova P, Reinhold D, Schraven B, Horejsi V, Malissen B, Malissen M
Eur J Immunol. 2007
PubMed ID: 17918199
Depletion of alveolar macrophages decreases the dissemination of a glucosylceramide-deficient mutant of Cryptococcus neoformans in immunodeficient mice.
Kechichian TB, Shea J, Del Poeta M
Infect Immun. 2007
PubMed ID: 17664261
Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells.
De Smedt M, Taghon T, Van de Walle I, De Smet G, Leclercq G, Plum J
Blood. 2007
PubMed ID: 17630354
p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.
Fasseu M, Aplan PD, Chopin M, Boissel N, Bories JC, Soulier J, von Boehmer H, Sigaux F, Regnault A
Blood. 2007
PubMed ID: 17507663
Loss of N-terminal charged residues of mouse CD3 epsilon chains generates isoforms modulating antigen T cell receptor-mediated signals and T cell receptor-CD3 interactions.
Bello R, Feito MJ, Ojeda G, Portolés P, Rojo JM
J Biol Chem. 2007
PubMed ID: 17561508
Keeping the (kinase) party going: SLP-76 and ITK dance to the beat.
Qi Q, August A
Sci STKE. 2007
PubMed ID: 17652306
CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair.
Lax S, Hou TZ, Jenkinson E, Salmon M, MacFadyen JR, Isacke CM, Anderson G, Cunningham AF, Buckley CD
FEBS Lett. 2007
PubMed ID: 17628549
CD3 and immunoglobulin G Fc receptor regulate cerebellar functions.
Nakamura K, Hirai H, Torashima T, Miyazaki T, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Tsukamoto K, Nishimura H, Ono M, Watanabe M, Hirose S
Mol Cell Biol. 2007
PubMed ID: 17502348
The membrane-proximal portion of CD3 epsilon associates with the serine/threonine kinase GRK2.
DeFord-Watts LM, Young JA, Pitcher LA, van Oers NS
J Biol Chem. 2007
PubMed ID: 17420248
Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells.
Meier D, Bornmann C, Chappaz S, Schmutz S, Otten LA, Ceredig R, Acha-Orbea H, Finke D
Immunity. 2007
PubMed ID: 17521585
Microarray analysis of Myf5-/-:MyoD-/- hypoplastic mouse lungs reveals a profile of genes involved in pneumocyte differentiation.
Baguma-Nibasheka M, Angka HE, Inanlou MR, Kablar B
Histol Histopathol. 2007
PubMed ID: 17330803
FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection.
Wilson TJ, Presti RM, Tassi I, Overton ET, Cella M, Colonna M
Blood. 2007
PubMed ID: 17213291
Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling.
Kuhns MS, Davis MM
Immunity. 2007
PubMed ID: 17368054
Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46.
Walzer T, Bléry M, Chaix J, Fuseri N, Chasson L, Robbins SH, Jaeger S, André P, Gauthier L, Daniel L, Chemin K, Morel Y, Dalod M, Imbert J, Pierres M, Moretta A, Romagné F, Vivier E
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360655
Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN.
Hervas-Stubbs S, Rueda P, Lopez L, Leclerc C
J Immunol. 2007
PubMed ID: 17277142
Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits.
Sigalov AB, Aivazian DA, Uversky VN, Stern LJ
Biochemistry. 2006
PubMed ID: 17176095
A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor.
Xu C, Call ME, Wucherpfennig KW
J Biol Chem. 2006
PubMed ID: 17023417
Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference.
Li CJ
J Cell Physiol. 2006
PubMed ID: 17001685
Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells.
Almeida AR, Zaragoza B, Freitas AA
Int Immunol. 2006
PubMed ID: 16987936
The impact of T cell intrinsic antigen adaptation on peripheral immune tolerance.
Singh NJ, Chen C, Schwartz RH
PLoS Biol. 2006
PubMed ID: 17048986
Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis.
Fukuyama S, Nagatake T, Kim DY, Takamura K, Park EJ, Kaisho T, Tanaka N, Kurono Y, Kiyono H
J Immunol. 2006
PubMed ID: 16982861
Visualization of the earliest steps of gammadelta T cell development in the adult thymus.
Prinz I, Sansoni A, Kissenpfennig A, Ardouin L, Malissen M, Malissen B
Nat Immunol. 2006
PubMed ID: 16878135
The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity.
Genton C, Wang Y, Izui S, Malissen B, Delsol G, Fournié GJ, Malissen M, Acha-Orbea H
J Immunol. 2006
PubMed ID: 16887989
Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment.
Martin B, Bécourt C, Bienvenu B, Lucas B
Blood. 2006
PubMed ID: 16527889
Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.
Schindler M, Münch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, Müller-Trutwin MC, Novembre FJ, Peeters M, Courgnaud V, Bailes E, Roques P, Sodora DL, Silvestri G, Sharp PM, Hahn BH, Kirchhoff F
Cell. 2006
PubMed ID: 16777597
Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors.
de Pooter RF, Schmitt TM, de la Pompa JL, Fujiwara Y, Orkin SH, Zúñiga-Pflücker JC
J Immunol. 2006
PubMed ID: 16621992
Identification of substrates of human protein-tyrosine phosphatase PTPN22.
Wu J, Katrekar A, Honigberg LA, Smith AM, Conn MT, Tang J, Jeffery D, Mortara K, Sampang J, Williams SR, Buggy J, Clark JM
J Biol Chem. 2006
PubMed ID: 16461343
CD8+ T cells are effector cells of contact dermatitis to common skin allergens in mice.
Vocanson M, Hennino A, Cluzel-Tailhardat M, Saint-Mezard P, Benetiere J, Chavagnac C, Berard F, Kaiserlian D, Nicolas JF
J Invest Dermatol. 2006
PubMed ID: 16456532
Different role for mouse and human CD3delta/epsilon heterodimer in preT cell receptor (preTCR) function: human CD3delta/epsilon heterodimer restores the defective preTCR function in CD3gamma- and CD3gammadelta-deficient mice.
Pan Q, Brodeur JF, Drbal K, Dave VP
Mol Immunol. 2006
PubMed ID: 16412509
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
Nature. 2006
PubMed ID: 16554811
Stoichiometry of the murine gammadelta T cell receptor.
Hayes SM, Love PE
J Exp Med. 2006
PubMed ID: 16418397
A transgenic mouse model for TEL-JAK2-induced B-cell lymphoma/leukemia.
dos Santos NR, Ghysdael J
Leukemia. 2006
PubMed ID: 16281066
Selective upregulation of immune regulatory and effector cytokine synthesis by intestinal intraepithelial lymphocytes following CD43 costimulation.
Montufar-Solis D, Garza T, Klein JR
Biochem Biophys Res Commun. 2005
PubMed ID: 16246302
CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens.
Marquez ME, Ellmeier W, Sanchez-Guajardo V, Freitas AA, Acuto O, Di Bartolo V
J Immunol. 2005
PubMed ID: 16301646
TCR signaling inhibits glucocorticoid-induced apoptosis in murine thymocytes depending on the stage of development.
Erlacher M, Knoflach M, Stec IE, Böck G, Wick G, Wiegers GJ
Eur J Immunol. 2005
PubMed ID: 16224812
Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint.
Williams JA, Hathcock KS, Klug D, Harada Y, Choudhury B, Allison JP, Abe R, Hodes RJ
J Immunol. 2005
PubMed ID: 16177059
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.
Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, Watts JD, Hood L, Aebersold R
Nat Methods. 2005
PubMed ID: 16094384
The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function.
Szymczak AL, Workman CJ, Gil D, Dilioglou S, Vignali KM, Palmer E, Vignali DA
J Immunol. 2005
PubMed ID: 15972658
Peripheral CD8+CD25+ T lymphocytes from MHC class II-deficient mice exhibit regulatory activity.
Bienvenu B, Martin B, Auffray C, Cordier C, Bécourt C, Lucas B
J Immunol. 2005
PubMed ID: 15972655
Effects of increasing IL-7 availability on lymphocytes during and after lymphopenia-induced proliferation.
Bosco N, Agenès F, Ceredig R
J Immunol. 2005
PubMed ID: 15972643
Multifocal structure of the T cell - dendritic cell synapse.
Brossard C, Feuillet V, Schmitt A, Randriamampita C, Romao M, Raposo G, Trautmann A
Eur J Immunol. 2005
PubMed ID: 15909310
Selective expression of the 21-kilodalton tyrosine-phosphorylated form of TCR zeta promotes the emergence of T cells with autoreactive potential.
Pitcher LA, Mathis MA, Subramanian S, Young JA, Wakeland EK, Love PE, van Oers NS
J Immunol. 2005
PubMed ID: 15879101
Negative regulation of lymphocyte activation by the adaptor protein LAX.
Zhu M, Granillo O, Wen R, Yang K, Dai X, Wang D, Zhang W
J Immunol. 2005
PubMed ID: 15843560
Rapid in vivo analysis of mutant forms of the LAT adaptor using Pax5-Lat double-deficient pro-B cells.
Ardouin L, Rolink AG, Mura AM, Gommeaux J, Melchers F, Busslinger M, Malissen M, Malissen B
Eur J Immunol. 2005
PubMed ID: 15719364
T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells.
Purtic B, Pitcher LA, van Oers NS, Wülfing C
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15703298
Defective proximal TCR signaling inhibits CD8+ tumor-infiltrating lymphocyte lytic function.
Koneru M, Schaer D, Monu N, Ayala A, Frey AB
J Immunol. 2005
PubMed ID: 15699109
Role of the proto-oncogene Pokemon in cellular transformation and ARF repression.
Maeda T, Hobbs RM, Merghoub T, Guernah I, Zelent A, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP
Nature. 2005
PubMed ID: 15662416
High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia.
Bijl J, Sauvageau M, Thompson A, Sauvageau G
Genes Dev. 2005
PubMed ID: 15655112
Expression of CD3 antigens in renal tubule epithelium and renal oncocytomas.
Alroy J, Ucci AA, Azabdoaftari G, Banner BF, Cheville JC
Pathol Res Pract. 2005
PubMed ID: 16308105
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes.
McCarty N, Paust S, Ikizawa K, Dan I, Li X, Cantor H
Nat Immunol. 2005
PubMed ID: 15608642
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ
Nat Biotechnol. 2005
PubMed ID: 15592455
Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.
Arnett KL, Harrison SC, Wiley DC
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15534202
Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia.
Brenner O, Levanon D, Negreanu V, Golubkov O, Fainaru O, Woolf E, Groner Y
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15514019
Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.
de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F
J Clin Invest. 2004
PubMed ID: 15546002
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
Palacios EH, Weiss A
Oncogene. 2004
PubMed ID: 15489916
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Ablation of TrkA function in the immune system causes B cell abnormalities.
Coppola V, Barrick CA, Southon EA, Celeste A, Wang K, Chen B, Haddad el-B, Yin J, Nussenzweig A, Subramaniam A, Tessarollo L
Development. 2004
PubMed ID: 15459109
BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses.
Ye Q, Wang L, Wells AD, Tao R, Han R, Davidson A, Scott ML, Hancock WW
Eur J Immunol. 2004
PubMed ID: 15368291
Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice.
Mok H, Mendoza M, Prchal JT, Balogh P, Schumacher A
Development. 2004
PubMed ID: 15342464
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S
Genome Res. 2004
PubMed ID: 15342556
Lipid rafts mediate association of LFA-1 and CD3 and formation of the immunological synapse of CTL.
Marwali MR, MacLeod MA, Muzia DN, Takei F
J Immunol. 2004
PubMed ID: 15322154
Adult-onset Alopecia areata is a complex polygenic trait in the C3H/HeJ mouse model.
Sundberg JP, Silva KA, Li R, Cox GA, King LE
J Invest Dermatol. 2004
PubMed ID: 15245428
Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.
Kjer-Nielsen L, Dunstone MA, Kostenko L, Ely LK, Beddoe T, Mifsud NA, Purcell AW, Brooks AG, McCluskey J, Rossjohn J
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15136729
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC
Anal Chem. 2004
PubMed ID: 15144186
A single class II myosin modulates T cell motility and stopping, but not synapse formation.
Jacobelli J, Chmura SA, Buxton DB, Davis MM, Krummel MF
Nat Immunol. 2004
PubMed ID: 15064761
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins.
Heissmeyer V, Macián F, Im SH, Varma R, Feske S, Venuprasad K, Gu H, Liu YC, Dustin ML, Rao A
Nat Immunol. 2004
PubMed ID: 14973438
Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.
Gorska MM, Stafford SJ, Cen O, Sur S, Alam R
J Exp Med. 2004
PubMed ID: 14757743
T cell-independent somatic hypermutation in murine B cells with an immature phenotype.
Mao C, Jiang L, Melo-Jorge M, Puthenveetil M, Zhang X, Carroll MC, Imanishi-Kari T
Immunity. 2004
PubMed ID: 14975236
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Dendritic cell maturation controls adhesion, synapse formation, and the duration of the interactions with naive T lymphocytes.
Benvenuti F, Lagaudrière-Gesbert C, Grandjean I, Jancic C, Hivroz C, Trautmann A, Lantz O, Amigorena S
J Immunol. 2004
PubMed ID: 14688337
High expression of active CDK6 in the cytoplasm of CD8 memory cells favors rapid division.
Veiga-Fernandes H, Rocha B
Nat Immunol. 2004
PubMed ID: 14647273
CD38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD3-zeta subunit of the T cell antigen receptor.
Muñoz P, Navarro MD, Pavón EJ, Salmerón J, Malavasi F, Sancho J, Zubiaur M
J Biol Chem. 2003
PubMed ID: 14523017
Age-related defects in CD4+ T cell activation reversed by glycoprotein endopeptidase.
Garcia GG, Miller RA
Eur J Immunol. 2003
PubMed ID: 14635057
Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways.
Butler JJ, Mader JS, Watson CL, Zhang H, Blay J, Hoskin DW
J Cell Biochem. 2003
PubMed ID: 12874832
Bcl11b is required for differentiation and survival of alphabeta T lymphocytes.
Wakabayashi Y, Watanabe H, Inoue J, Takeda N, Sakata J, Mishima Y, Hitomi J, Yamamoto T, Utsuyama M, Niwa O, Aizawa S, Kominami R
Nat Immunol. 2003
PubMed ID: 12717433
The lymphoid past of mouse plasmacytoid cells and thymic dendritic cells.
Corcoran L, Ferrero I, Vremec D, Lucas K, Waithman J, O'Keeffe M, Wu L, Wilson A, Shortman K
J Immunol. 2003
PubMed ID: 12734335
On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells.
Martin B, Bourgeois C, Dautigny N, Lucas B
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12719530
Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL.
Tremblay M, Herblot S, Lecuyer E, Hoang T
J Biol Chem. 2003
PubMed ID: 12566462
Forced expression of the Fc receptor gamma-chain renders human T cells hyperresponsive to TCR/CD3 stimulation.
Nambiar MP, Fisher CU, Kumar A, Tsokos CG, Warke VG, Tsokos GC
J Immunol. 2003
PubMed ID: 12626537
T cell receptor can be recruited to a subset of plasma membrane rafts, independently of cell signaling and attendantly to raft clustering.
Giurisato E, McIntosh DP, Tassi M, Gamberucci A, Benedetti A
J Biol Chem. 2003
PubMed ID: 12499387
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12522270
Expression of CD3 epsilon subunit in gastric parietal cells: a possible role in signal transduction?
Banner B, Spicer Z, Alroy J
Pathol Res Pract. 2003
PubMed ID: 12812314
Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient mice.
Pozdnyakova O, Guttormsen HK, Lalani FN, Carroll MC, Kasper DL
J Immunol. 2003
PubMed ID: 12496386
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
In vitro production and characterization of partly assembled human CD3 complexes.
Kastrup J, Pedersen LØ, Dietrich J, Lauritsen JP, Menné C, Geisler C
Scand J Immunol. 2002
PubMed ID: 12410792
Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers.
Almeida AR, Legrand N, Papiernik M, Freitas AA
J Immunol. 2002
PubMed ID: 12391195
T lymphocytes potentiate murine dendritic cells to produce IL-12.
Rizzitelli A, Berthier R, Collin V, Candéias SM, Marche PN
J Immunol. 2002
PubMed ID: 12370354
A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory.
Bourgeois C, Rocha B, Tanchot C
Science. 2002
PubMed ID: 12242444
Therapeutic effects of tumor reactive CD4+ cells generated from tumor-primed lymph nodes using anti-CD3/anti-CD28 monoclonal antibodies.
Li Q, Yu B, Grover AC, Zeng X, Chang AE
J Immunother. 2002
PubMed ID: 12142553
Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation.
Gil D, Schamel WW, Montoya M, Sánchez-Madrid F, Alarcón B
Cell. 2002
PubMed ID: 12110186
Induction of T helper type 2 immunity by a point mutation in the LAT adaptor.
Aguado E, Richelme S, Nuñez-Cruz S, Miazek A, Mura AM, Richelme M, Guo XJ, Sainty D, He HT, Malissen B, Malissen M
Science. 2002
PubMed ID: 12065839
Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.
Wolfer A, Wilson A, Nemir M, MacDonald HR, Radtke F
Immunity. 2002
PubMed ID: 12121668
Thymopoiesis requires Pax9 function in thymic epithelial cells.
Hetzer-Egger C, Schorpp M, Haas-Assenbaum A, Balling R, Peters H, Boehm T
Eur J Immunol. 2002
PubMed ID: 11932925
Involvement of receptor-interacting protein 2 in innate and adaptive immune responses.
Chin AI, Dempsey PW, Bruhn K, Miller JF, Xu Y, Cheng G
Nature. 2002
PubMed ID: 11894097
Phosphorylation of the N-terminal and C-terminal CD3-epsilon-ITAM tyrosines is differentially regulated in T cells.
Guirado M, de Aós I, Orta T, Rivas L, Terhorst C, Zubiaur M, Sancho J
Biochem Biophys Res Commun. 2002
PubMed ID: 11855827
Characterization of T cell differentiation in the murine gut.
Lambolez F, Azogui O, Joret AM, Garcia C, von Boehmer H, Di Santo J, Ezine S, Rocha B
J Exp Med. 2002
PubMed ID: 11854357
Binding of the Galanthus nivalis agglutinin to thymocytes reveals alterations in surface glycosylation during T-cell development.
Sinkora J, Kolínská J, Reháková Z, Cerný J, Doubravská L
Scand J Immunol. 2002
PubMed ID: 11896936
Adapters in lymphocyte signaling.
Leo A, Wienands J, Baier G, Horejsi V, Schraven B
J Clin Invest. 2002
PubMed ID: 11827988
CD38 is associated with lipid rafts and upon receptor stimulation leads to Akt/protein kinase B and Erk activation in the absence of the CD3-zeta immune receptor tyrosine-based activation motifs.
Zubiaur M, Fernández O, Ferrero E, Salmerón J, Malissen B, Malavasi F, Sancho J
J Biol Chem. 2002
PubMed ID: 11689561
The ontogeny of B cells in the thymus of normal, CD3 epsilon knockout (KO), RAG-2 KO and IL-7 transgenic mice.
Ceredig R
Int Immunol. 2002
PubMed ID: 11751756
TCRA gene rearrangement in immature thymocytes in absence of CD3, pre-TCR, and TCR signaling.
Mancini SJ, Candéias SM, Di Santo JP, Ferrier P, Marche PN, Jouvin-Marche E
J Immunol. 2001
PubMed ID: 11591775
T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors.
Almeida AR, Borghans JA, Freitas AA
J Exp Med. 2001
PubMed ID: 11535628
Molecular characterisation of the tammar wallaby (Macropus eugenii) CD3 epsilon chain cDNA.
Old JM, Deane EM, Harrison GA
Mol Immunol. 2001
PubMed ID: 11684291
T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase.
Magnan A, Di Bartolo V, Mura AM, Boyer C, Richelme M, Lin YL, Roure A, Gillet A, Arrieumerlou C, Acuto O, Malissen B, Malissen M
J Exp Med. 2001
PubMed ID: 11514605
Adaptive tolerance of CD4+ T cells in vivo: multiple thresholds in response to a constant level of antigen presentation.
Tanchot C, Barber DL, Chiodetti L, Schwartz RH
J Immunol. 2001
PubMed ID: 11489985
Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex.
Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H, Ohno H, Shirasawa T, Kuriyama T, O'Shea JJ, Saito T
J Biol Chem. 2001
PubMed ID: 11349123
Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer.
Sun ZJ, Kim KS, Wagner G, Reinherz EL
Cell. 2001
PubMed ID: 11439187
The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.
Kirchgessner H, Dietrich J, Scherer J, Isomäki P, Korinek V, Hilgert I, Bruyns E, Leo A, Cope AP, Schraven B
J Exp Med. 2001
PubMed ID: 11390434
Intracellular redistribution of nucleolin upon interaction with the CD3epsilon chain of the T cell receptor complex.
Gil D, Gutiérrez D, Alarcón B
J Biol Chem. 2001
PubMed ID: 11115514
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Complementary effects of TNF and lymphotoxin on the formation of germinal center and follicular dendritic cells.
Wang Y, Wang J, Sun Y, Wu Q, Fu YX
J Immunol. 2001
PubMed ID: 11123309
Fourteen years' follow-up of an autoimmune patient lacking the CD3 gamma subunit of the T-lymphocyte receptor.
Allende LM, García-Pérez MA, Moreno A, Ruíz-Contreras J, Arnaiz-Villena A
Blood. 2000
PubMed ID: 11186279
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Biochemical analysis of the Xenopus laevis TCR/CD3 complex supports the "stepwise evolution" model.
Göbel TW, Meier EL, Du Pasquier L
Eur J Immunol. 2000
PubMed ID: 11069057
CD3epsilon homologues in the chondrostean fish Acipenser ruthenus.
Alabyev BY, Guselnikov SV, Najakshin AM, Mechetina LV, Taranin AV
Immunogenetics. 2000
PubMed ID: 11061286
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
The mechanism of phospholipase C-gamma1 regulation.
Kim MJ, Kim E, Ryu SH, Suh PG
Exp Mol Med. 2000
PubMed ID: 11048639
Heterodimeric CD3epsilongamma extracellular domain fragments: production, purification and structural analysis.
Kim KS, Sun ZY, Wagner G, Reinherz EL
J Mol Biol. 2000
PubMed ID: 10993731
Function of CD3 epsilon-mediated signals in T cell development.
Sommers CL, Dejarnette JB, Huang K, Lee J, El-Khoury D, Shores EW, Love PE
J Exp Med. 2000
PubMed ID: 10993922
Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte.
Outram SV, Varas A, Pepicelli CV, Crompton T
Immunity. 2000
PubMed ID: 10981962
Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets.
van Ewijk W, Holländer G, Terhorst C, Wang B
Development. 2000
PubMed ID: 10725235
Possible role of the plasminogen receptor as a site of interaction of the human immunodeficiency virus p24 immunosuppressive heptapeptide Ch7 with the host immune system.
Giacomini E, Chersi A, Giordani L, Luzzati AL
Scand J Immunol. 2000
PubMed ID: 10722370
[Overexpression of Bcl-2 inhibited T lymphocyte apoptosis mediated by CD3 epsilon molecule]
Yang X, Liu Y, Zheng D
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1999
PubMed ID: 12567487
Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development.
Dear TN, Boehm T
Mech Dev. 1999
PubMed ID: 10559499
Chronic marginal vitamin A status affects the distribution and function of T cells and natural T cells in aging Lewis rats.
Dawson HD, Ross AC
J Nutr. 1999
PubMed ID: 10498748
Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells.
Moriggl R, Sexl V, Piekorz R, Topham D, Ihle JN
Immunity. 1999
PubMed ID: 10485657
CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells.
Yamazaki T, Hamano Y, Tashiro H, Itoh K, Nakano H, Miyatake S, Saito T
J Biol Chem. 1999
PubMed ID: 10373416
The bHLH gene Hes1 is essential for expansion of early T cell precursors.
Tomita K, Hattori M, Nakamura E, Nakanishi S, Minato N, Kageyama R
Genes Dev. 1999
PubMed ID: 10323870
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells.
Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Deursen J, Sangster MY, Bunting KD, Grosveld GC, Ihle JN
Immunity. 1999
PubMed ID: 10072077
T lymphocyte development in the absence of CD3 epsilon or CD3 gamma delta epsilon zeta.
Wang B, Wang N, Whitehurst CE, She J, Chen J, Terhorst C
J Immunol. 1999
PubMed ID: 9886373
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Altered thymic positive selection and intracellular signals in Cbl-deficient mice.
Naramura M, Kole HK, Hu RJ, Gu H
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9861006
Specific requirement for CD3epsilon in T cell development.
DeJarnette JB, Sommers CL, Huang K, Woodside KJ, Emmons R, Katz K, Shores EW, Love PE
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9843989
Expression of a CD3 epsilon transgene in CD3 epsilon(null) mice does not restore CD3 gamma and delta expression but efficiently rescues T cell development from a subpopulation of prothymocytes.
Wang N, Wang B, Salio M, Allen D, She J, Terhorst C
Int Immunol. 1998
PubMed ID: 9885898
IL-12 enhances antibody responses to T-independent polysaccharide vaccines in the absence of T and NK cells.
Buchanan RM, Arulanandam BP, Metzger DW
J Immunol. 1998
PubMed ID: 9820529
A mouse carrying genetic defect in the choice between T and B lymphocytes.
Tokoro Y, Sugawara T, Yaginuma H, Nakauchi H, Terhorst C, Wang B, Takahama Y
J Immunol. 1998
PubMed ID: 9794386
CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling.
Hannier S, Tournier M, Bismuth G, Triebel F
J Immunol. 1998
PubMed ID: 9780176
Increased PGE2 production mediates the in vitro inhibitory effect of the human immunodeficiency virus P24 immunosuppressive heptapeptide Ch7.
Giacomini E, Giordani L, di Modugno F, Chersi A, Luzzati AL
Scand J Immunol. 1998
PubMed ID: 9743208
Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.
Fütterer K, Wong J, Grucza RA, Chan AC, Waksman G
J Mol Biol. 1998
PubMed ID: 9698567
T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane.
Bruyns E, Marie-Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, Autschbach F, Bensussan A, Meuer S, Schraven B
J Exp Med. 1998
PubMed ID: 9687533
Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining.
Hempel WM, Stanhope-Baker P, Mathieu N, Huang F, Schlissel MS, Ferrier P
Genes Dev. 1998
PubMed ID: 9694796
Characterization of the region involved in CD3 pairwise interactions within the T cell receptor complex.
Borroto A, Mallabiabarrena A, Albar JP, Martínez-A C, Alarcón B
J Biol Chem. 1998
PubMed ID: 9582308
T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma).
Shores EW, Ono M, Kawabe T, Sommers CL, Tran T, Lui K, Udey MC, Ravetch J, Love PE
J Exp Med. 1998
PubMed ID: 9529325
Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-kappaB factors.
Ott M, Lovett JL, Mueller L, Verdin E
J Immunol. 1998
PubMed ID: 9510190
The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci.
Ardouin L, Ismaili J, Malissen B, Malissen M
J Exp Med. 1998
PubMed ID: 9419216
Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model.
San José E, Sahuquillo AG, Bragado R, Alarcón B
Eur J Immunol. 1998
PubMed ID: 9485181
In vivo association of CD5 with tyrosine-phosphorylated ZAP-70 and p21 phospho-zeta molecules in human CD3+ thymocytes.
Gary-Gouy H, Lang V, Sarun S, Boumsell L, Bismuth G
J Immunol. 1997
PubMed ID: 9378960
Tyrosine phosphorylation of the CD3-epsilon subunit of the T cell antigen receptor mediates enhanced association with phosphatidylinositol 3-kinase in Jurkat T cells.
de Aós I, Metzger MH, Exley M, Dahl CE, Misra S, Zheng D, Varticovski L, Terhorst C, Sancho J
J Biol Chem. 1997
PubMed ID: 9312149
gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules.
Feito MJ, Bragardo M, Buonfiglio D, Bonissoni S, Bottarel F, Malavasi F, Dianzani U
Int Immunol. 1997
PubMed ID: 9263011
A new 12-kilodalton dimer associated with pre-TCR complex and clonotype-independent CD3 complex on immature thymocytes.
Takase K, Wakizaka K, von Boehmer H, Wada I, Moriya H, Saito T
J Immunol. 1997
PubMed ID: 9218590
Thymocytes and RelB-dependent medullary epithelial cells provide growth-promoting and organization signals, respectively, to thymic medullary stromal cells.
Naspetti M, Aurrand-Lions M, DeKoning J, Malissen M, Galland F, Lo D, Naquet P
Eur J Immunol. 1997
PubMed ID: 9209490
A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development.
Wiest DL, Ashe JM, Howcroft TK, Lee HM, Kemper DM, Negishi I, Singer DS, Singer A, Abe R
Immunity. 1997
PubMed ID: 9208839
Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway.
Ott M, Emiliani S, Van Lint C, Herbein G, Lovett J, Chirmule N, McCloskey T, Pahwa S, Verdin E
Science. 1997
PubMed ID: 9045614
Identification of a committed T cell precursor population in adult human peripheral blood.
Bruno L, Res P, Dessing M, Cella M, Spits H
J Exp Med. 1997
PubMed ID: 9120393
Isolation of the most immature population of murine fetal thymocytes that includes progenitors capable of generating T, B, and myeloid cells.
Hattori N, Kawamoto H, Katsura Y
J Exp Med. 1996
PubMed ID: 8920877
Enhancement of CD3-mediated thymocyte apoptosis by the cross-linkage of heat-stable antigen.
Hitsumoto Y, Song DS, Okada M, Hamada F, Saheki S, Takeuchi N
Immunology. 1996
PubMed ID: 8943715
Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase.
Pani G, Fischer KD, Mlinaric-Rascan I, Siminovitch KA
J Exp Med. 1996
PubMed ID: 9064344
Interferon-gamma (IFN-gamma) can counteract the in vitro inhibitory effect of an HIV p24 immunosuppressive heptapeptide.
Luzzati AL, Boirivant M, Giacomini E, Giordani L, Di Modugno F, Chersi A
Clin Exp Immunol. 1996
PubMed ID: 8809126
Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.
Bouvier G, Watrin F, Naspetti M, Verthuy C, Naquet P, Ferrier P
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8755570
Lck dependence of signaling pathways activated by gamma-irradiation and CD3 epsilon engagement in RAG-1(-/-)-immature thymocytes.
Wu G, Danska JS, Guidos CJ
Int Immunol. 1996
PubMed ID: 8757961
Development of Valpha4+ NK T cells in the early stages of embryogenesis.
Makino Y, Kanno R, Koseki H, Taniguchi M
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8692847
Porcine CD3 epsilon: its characterization, expression and involvement in activation of porcine T lymphocytes.
Kirkham PA, Takamatsu H, Yang H, Parkhouse RM
Immunology. 1996
PubMed ID: 8675218
CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation.
Byth KF, Conroy LA, Howlett S, Smith AJ, May J, Alexander DR, Holmes N
J Exp Med. 1996
PubMed ID: 8666928
Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement.
Xu Y, Davidson L, Alt FW, Baltimore D
Immunity. 1996
PubMed ID: 8612132
Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex.
Nakano H, Yamazaki T, Miyatake S, Nozaki N, Kikuchi A, Saito T
J Biol Chem. 1996
PubMed ID: 8626450
Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling.
Stanners J, Kabouridis PS, McGuire KL, Tsoukas CD
J Biol Chem. 1995
PubMed ID: 8530500
Physical dissociation of the TCR-CD3 complex accompanies receptor ligation.
Kishimoto H, Kubo RT, Yorifuji H, Nakayama T, Asano Y, Tada T
J Exp Med. 1995
PubMed ID: 7500045
Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.
Malissen M, Gillet A, Ardouin L, Bouvier G, Trucy J, Ferrier P, Vivier E, Malissen B
EMBO J. 1995
PubMed ID: 7588594
Essential role for ZAP-70 in both positive and negative selection of thymocytes.
Negishi I, Motoyama N, Nakayama K, Nakayama K, Senju S, Hatakeyama S, Zhang Q, Chan AC, Loh DY
Nature. 1995
PubMed ID: 7630421
Normal development and function of natural killer cells in CD3 epsilon delta 5/delta 5 mutant mice.
Renard V, Ardouin L, Malissen M, Milon G, Lebastard M, Gillet A, Malissen B, Vivier E
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7638228
CD3 delta and epsilon gene expression in CD3-CD16+ natural killer cell clones derived from thymic precursors.
DeNofrio D, Radcliff G, Weinhold KJ, Denning SM
Hum Immunol. 1995
PubMed ID: 7499176
Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance.
Bu JY, Shaw AS, Chan AC
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7761456
HIV-1 glycoprotein gp120 disrupts CD4-p56lck/CD3-T cell receptor interactions and inhibits CD3 signaling.
Hubert P, Bismuth G, Körner M, Debré P
Eur J Immunol. 1995
PubMed ID: 7774645
Barx1, a new mouse homeodomain transcription factor expressed in cranio-facial ectomesenchyme and the stomach.
Tissier-Seta JP, Mucchielli ML, Mark M, Mattei MG, Goridis C, Brunet JF
Mech Dev. 1995
PubMed ID: 7669690
Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120.
Dianzani U, Bragardo M, Buonfiglio D, Redoglia V, Funaro A, Portoles P, Rojo J, Malavasi F, Pileri A
Eur J Immunol. 1995
PubMed ID: 7539755
Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment.
Haynes BF, Heinly CS
J Exp Med. 1995
PubMed ID: 7699329
Over-expression of CD3 epsilon transgenes blocks T lymphocyte development.
Wang B, Levelt C, Salio M, Zheng D, Sancho J, Liu CP, She J, Huang M, Higgins K, Sunshine MJ
Int Immunol. 1995
PubMed ID: 7794823
Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29).
Müller B, Cooper L, Terhorst C
Immunol Lett. 1995
PubMed ID: 7541024
CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression.
Shinkai Y, Alt FW
Int Immunol. 1994
PubMed ID: 7947468
An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex.
Luzzati AL, Giacomini E, Giordani L, Viora M, Chersi A, Camponeschi B, Pugliese O
Cell Immunol. 1994
PubMed ID: 7517794
Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif.
Gauen LK, Zhu Y, Letourneur F, Hu Q, Bolen JB, Matis LA, Klausner RD, Shaw AS
Mol Cell Biol. 1994
PubMed ID: 8196616
Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.
Chan AC, van Oers NS, Tran A, Turka L, Law CL, Ryan JC, Clark EA, Weiss A
J Immunol. 1994
PubMed ID: 8176201
Expression of the zeta protein subunit in CD3- NK effectors derived from human thymus.
Beecher MS, Baiocchi RA, Linett ML, Krajewski CA, Caligiuri MA
Cell Immunol. 1994
PubMed ID: 7514106
HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro.
Dürrbaum-Landmann I, Kaltenhäuser E, Flad HD, Ernst M
J Leukoc Biol. 1994
PubMed ID: 8145026
Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function.
Hubbe M, Altevogt P
Eur J Immunol. 1994
PubMed ID: 8125140
Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.
Levelt CN, Mombaerts P, Iglesias A, Tonegawa S, Eichmann K
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8248261
Chromosomal localization of uroplakin genes of cattle and mice.
Ryan AM, Womack JE, Yu J, Lin JH, Wu XR, Sun TT, Clarke V, D'Eustachio P
Mamm Genome. 1993
PubMed ID: 8281015
Elimination of HIV-infected cells by lymphocytes armed with a bifunctional antibody to gp120 of HIV and CD3.
Okada H, Momota H, Okada N, Okamoto T, Azuma T
Immunol Lett. 1993
PubMed ID: 8125527
Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120.
Oravecz T, Norcross MA
AIDS Res Hum Retroviruses. 1993
PubMed ID: 7506554
Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells.
Wange RL, Malek SN, Desiderio S, Samelson LE
J Biol Chem. 1993
PubMed ID: 8366117
Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency.
Soudais C, de Villartay JP, Le Deist F, Fischer A, Lisowska-Grospierre B
Nat Genet. 1993
PubMed ID: 8490660
Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells.
Morse HC
J Immunol. 1992
PubMed ID: 1431091
Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes.
Lanier LL, Chang C, Spits H, Phillips JH
J Immunol. 1992
PubMed ID: 1387664
The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope.
Luzzati AL, Giacomini E, Giordani L, Pugliese O, Viora M, Chersi A
Immunol Lett. 1992
PubMed ID: 1385321
Structural analysis of low TCR-CD3 complex expression in T cells of an immunodeficient patient.
Thoenes G, Soudais C, le Deist F, Griscelli C, Fischer A, Lisowska-Grospierre B
J Biol Chem. 1992
PubMed ID: 1370449
A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx.
Ruegg CL, Strand M
Cell Immunol. 1991
PubMed ID: 1832084
Genetic linkage analysis and homology relationships of genes located on human chromosome 11q.
Charmley P, Nguyen J, Wei S, Gatti RA
Genomics. 1991
PubMed ID: 1679745
Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.
Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G
J Clin Invest. 1990
PubMed ID: 1979339
The implications of subunit interactions for the structure of the T cell receptor-CD3 complex.
Koning F, Maloy WL, Coligan JE
Eur J Immunol. 1990
PubMed ID: 2138083
Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV.
Luzzati AL, Pugliese O, Giacomini E, Giordani L, Quintieri F, Hraba T, Mach O, Krchnák V, Vágner J
Folia Biol (Praha). 1990
PubMed ID: 2111780
The mouse CD3-gamma, -delta, and -epsilon genes reside within 50 kilobases on chromosome 9, whereas CD3-zeta maps to chromosome 1, band H.
Letourneur F, Mattei MG, Malissen B
Immunogenetics. 1989
PubMed ID: 2522910
Genetic mapping of mouse T3d and T3e between Apoa1 and Ncam.
Miller RD, Ozaki JH, Riblet RJ, Gold DP
Immunogenetics. 1989
PubMed ID: 2512252
Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter.
Clevers HC, Dunlap S, Wileman TE, Terhorst C
Proc Natl Acad Sci U S A. 1988
PubMed ID: 3267235
Characterization and expression of the murine CD3-epsilon gene.
Clevers H, Dunlap S, Saito H, Georgopoulos K, Wileman T, Terhorst C
Proc Natl Acad Sci U S A. 1988
PubMed ID: 2973066
Molecular organization of the human CD3 gene family on chromosome 11q23.
Evans GA, Lewis KA, Lawless GM
Immunogenetics. 1988
PubMed ID: 2971614
Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family.
Gold DP, Clevers H, Alarcon B, Dunlap S, Novotny J, Williams AF, Terhorst C
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3478717
The gene encoding the epsilon subunit of the T3/T-cell receptor complex maps to chromosome 11 in humans and to chromosome 9 in mice.
Gold DP, van Dongen JJ, Morton CC, Bruns GA, van den Elsen P, Geurts van Kessel AH, Terhorst C
Proc Natl Acad Sci U S A. 1987
PubMed ID: 2882512
Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex.
Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C
Nature. 1986
PubMed ID: 3012357
Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein.
van den Elsen P, Shepley BA, Cho M, Terhorst C
Nature. 1985
PubMed ID: 2859526

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	916	12501	315609
EnsEMBL Gene(s)	ENSG00000198851 LRG_38	ENSMUSG00000032093	ENSRNOG00000016069
Unigene	Hs.3003	Mm.210361	Rn.96221
Homologene	CD3E	Cd3e	Cd3e
OMIM	186830	N/A	N/A
GeneCards	CD3E	N/A	N/A
Beta Cell Genomics	DT.100848394 DT.311930	DT.489704	N/A
Reactome	P07766	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	916	12501	315609

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site