CBL

Summary Top Help

Gene Description:

Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; Cbl proto-oncogene, E3 ubiquitin protein ligase

Synonyms:

RGD1561386, C-CBL, CBL2, Cbl, NSLL, CBL, Cbl-2, RNF55, 4732447J05Rik, c-Cbl, cbl

Orthologs:

Human CBL (protein-coding), Mouse Cbl (protein-coding), Rat Cbl (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd2	Mouse	chr9:32308040..98698811	66.39	764	6 no lod score

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:119076752..119178859 (102.11 kb) View in Genome Browser

(Mouse) NCBIM37 - chr9:43957345..44042129 (84.78 kb) View in Genome Browser

(Rat) RGSC3.4 - chr8:47135357..47211889 (76.53 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CBL:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
										no data		no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CBL:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 9

Biocarta: 3

Reactome: 5

NCI-Nature Pathway Interaction Database: 22

Gene Ontology: 25

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 476

c-Cbl Ubiquitin Ligase Regulates Focal Adhesion Protein Turnover and Myofibril Degeneration Induced by Neutrophil Protease Cathepsin G.
Rafiq K, Guo J, Vlasenko L, Guo X, Kolpakov MA, Sanjay A, Houser SR, Sabri A
J Biol Chem. 2012
PubMed ID: 22203672
Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction.
Okur MN, Ooi J, Fong CW, Martinez N, Garcia-Dominguez C, Rojas JM, Guy G, O'Bryan JP
Mol Cell Biol. 2012
PubMed ID: 22158968
Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulator.
Fu L, Rab A, Tang LP, Rowe SM, Bebok Z, Collawn JF
Biochem J. 2012
PubMed ID: 21995445
Tyrosine phosphorylated c-Cbl regulates platelet functional responses mediated by outside-in signaling.
Buitrago L, Langdon WY, Sanjay A, Kunapuli SP
Blood. 2011
PubMed ID: 21967979
c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway.
Oshikawa G, Nagao T, Wu N, Kurosu T, Miura O
J Biol Chem. 2011
PubMed ID: 21768087
The E3 ligase c-Cbl regulates dendritic cell activation.
Chiou SH, Shahi P, Wagner RT, Hu H, Lapteva N, Seethammagari M, Sun SC, Levitt JM, Spencer DM
EMBO Rep. 2011
PubMed ID: 21799517
CBL mutation in childhood therapy-related leukemia.
Shiba N, Taki T, Park MJ, Nagasawa M, Kanazawa T, Takita J, Ohnishi H, Sotomatsu M, Arakawa H, Hayashi Y
Leukemia. 2011
PubMed ID: 21494262
Role of c-Cbl carboxyl terminus in serotonin 5-HT2A receptor recycling and resensitization.
Baldys A, Raymond JR
J Biol Chem. 2011
PubMed ID: 21464131
The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination
Sévère N, Miraoui H, Marie PJ
J Biol Chem. 2011
PubMed ID: 21596750
B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster.
Schnyder T, Castello A, Feest C, Harwood NE, Oellerich T, Urlaub H, Engelke M, Wienands J, Bruckbauer A, Batista FD
Immunity. 2011
PubMed ID: 21703542
Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl.
Takahashi Y, Shimokawa N, Esmaeili-Mahani S, Morita A, Masuda H, Iwasaki T, Tamura J, Haglund K, Koibuchi N
FEBS Lett. 2011
PubMed ID: 21570973
[Expressions of c-Cbl, Cbl-b and EGFR and its role of prognosis in NSCLC].
Jiao X, Jin B, Qu X, Yan S, Hou K, Liu Y, Hu X
Zhongguo Fei Ai Za Zhi. 2011
PubMed ID: 21645455
Ubiquitin ligase c-Cbl is involved in tamoxifen-induced apoptosis of MCF-7 cells by downregulating the survival signals.
Yan SC, Liu YP, Zhang LY, Qu JL, Xu L, Liu J, Zhang Y, Hou KZ, Teng YE, Qu XJ
Acta Oncol. 2011
PubMed ID: 21175263
CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia.
Makishima H, Jankowska AM, McDevitt MA, O'Keefe C, Dujardin S, Cazzolli H, Przychodzen B, Prince C, Nicoll J, Siddaiah H, Shaik M, Szpurka H, Hsi E, Advani A, Paquette R, Maciejewski JP
Blood. 2011
PubMed ID: 21346257
c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLCγ1.
Meyer RD, Husain D, Rahimi N
Oncogene. 2011
PubMed ID: 21242968
CIN85 modulates the down-regulation of Fc gammaRIIa expression and function by c-Cbl in a PKC-dependent manner in human neutrophils.
Marois L, Vaillancourt M, Paré G, Gagné V, Fernandes MJ, Rollet-Labelle E, Naccache PH
J Biol Chem. 2011
PubMed ID: 21372129
Incidence of c-Cbl mutations in human acute myeloid leukaemias in an Australian patient cohort.
Ghassemifar R, Thien CB, Finlayson J, Joske D, Cull GM, Augustson B, Langdon WY
Pathology. 2011
PubMed ID: 21436637
Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders.
Naramura M, Nadeau S, Mohapatra B, Ahmad G, Mukhopadhyay C, Sattler M, Raja SM, Natarajan A, Band V, Band H
Oncotarget. 2011
PubMed ID: 21422499
An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding.
Sun Q, Ng C, Guy GR, Sivaraman J
FEBS Lett. 2011
PubMed ID: 21163258
Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration.
Duan L, Raja SM, Chen G, Virmani S, Williams SH, Clubb RJ, Mukhopadhyay C, Rainey MA, Ying G, Dimri M, Chen J, Reddi AL, Naramura M, Band V, Band H
J Biol Chem. 2011
PubMed ID: 20940296
Molecular mechanisms of cigarette smoke-induced proliferation of lung cells and prevention by vitamin C.
Dey N, Chattopadhyay DJ, Chatterjee IB
J Oncol. 2011
PubMed ID: 21772844
Cbl enforces Vav1 dependence and a restricted pathway of T cell development.
Chiang J, Hodes RJ
PLoS One. 2011
PubMed ID: 21490975
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl.
Lu J, Chiang J, Iyer RR, Thompson E, Kaneski CR, Xu DS, Yang C, Chen M, Hodes RJ, Lonser RR, Brady RO, Zhuang Z
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21098288
c-Cbl regulates glioma invasion through matrix metalloproteinase 2.
Lee H, Tsygankov AY
J Cell Biochem. 2010
PubMed ID: 20717917
As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia.
Mao JH, Sun XY, Liu JX, Zhang QY, Liu P, Huang QH, Li KK, Chen Q, Chen Z, Chen SJ
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21118980
The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival.
Adapala NS, Barbe MF, Langdon WY, Nakamura MC, Tsygankov AY, Sanjay A
J Biol Chem. 2010
PubMed ID: 20851882
Bag1 directly routes immature BCR-ABL for proteasomal degradation.
Tsukahara F, Maru Y
Blood. 2010
PubMed ID: 20675402
Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia.
Gelsi-Boyer V, Trouplin V, Roquain J, Adélaïde J, Carbuccia N, Esterni B, Finetti P, Murati A, Arnoulet C, Zerazhi H, Fezoui H, Tadrist Z, Nezri M, Chaffanet M, Mozziconacci MJ, Vey N, Birnbaum D
Br J Haematol. 2010
PubMed ID: 20880116
Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling.
Rathinam C, Thien CB, Flavell RA, Langdon WY
Cancer Cell. 2010
PubMed ID: 20951944
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation.
Wilson BG, Wang X, Shen X, McKenna ES, Lemieux ME, Cho YJ, Koellhoffer EC, Pomeroy SL, Orkin SH, Roberts CW
Cancer Cell. 2010
PubMed ID: 20951942
Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism.
Fernandes MS, Reddy MM, Croteau NJ, Walz C, Weisbach H, Podar K, Band H, Carroll M, Reiter A, Larson RA, Salgia R, Griffin JD, Sattler M
J Biol Chem. 2010
PubMed ID: 20622007
A human MAP kinase interactome.
Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
Nat Methods. 2010
PubMed ID: 20936779
Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease.
Qin S, Taglienti M, Nauli SM, Contrino L, Takakura A, Zhou J, Kreidberg JA
J Clin Invest. 2010
PubMed ID: 20852388
Methylation of TET2, CBL and CEBPA in Ph-negative myeloproliferative neoplasms.
Chim CS, Wan TS, Fung TK, Wong KF
J Clin Pathol. 2010
PubMed ID: 20671051
Germline mutations of the CBL gene define a new genetic syndrome with predisposition to juvenile myelomonocytic leukaemia.
Pérez B, Mechinaud F, Galambrun C, Ben Romdhane N, Isidor B, Philip N, Derain-Court J, Cassinat B, Lachenaud J, Kaltenbach S, Salmon A, Désirée C, Pereira S, Menot ML, Royer N, Fenneteau O, Baruchel A, Chomienne C, Verloes A, Cavé H
J Med Genet. 2010
PubMed ID: 20543203
Bimodal expression of Sprouty2 during the cell cycle is mediated by phase-specific Ras/MAPK and c-Cbl activities.
Mayer CE, Haigl B, Jantscher F, Siegwart G, Grusch M, Berger W, Sutterlüty H
Cell Mol Life Sci. 2010
PubMed ID: 20461437
Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.
Naramura M, Nandwani N, Gu H, Band V, Band H
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20805496
Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.
Niemeyer CM, Kang MW, Shin DH, Furlan I, Erlacher M, Bunin NJ, Bunda S, Finklestein JZ, Sakamoto KM, Gorr TA, Mehta P, Schmid I, Kropshofer G, Corbacioglu S, Lang PJ, Klein C, Schlegel PG, Heinzmann A, Schneider M, Starý J, van den Heuvel-Eibrink MM, Hasle H, Locatelli F, Sakai D, Archambeault S, Chen L, Russell RC, Sybingco SS, Ohh M, Braun BS, Flotho C, Loh ML
Nat Genet. 2010
PubMed ID: 20694012
Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration.
Wardega P, Heldin CH, Lennartsson J
Cell Signal. 2010
PubMed ID: 20494825
c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cells.
Ye S, Cihil K, Stolz DB, Pilewski JM, Stanton BA, Swiatecka-Urban A
J Biol Chem. 2010
PubMed ID: 20525683
Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype.
Martinelli S, De Luca A, Stellacci E, Rossi C, Checquolo S, Lepri F, Caputo V, Silvano M, Buscherini F, Consoli F, Ferrara G, Digilio MC, Cavaliere ML, van Hagen JM, Zampino G, van der Burgt I, Ferrero GB, Mazzanti L, Screpanti I, Yntema HG, Nillesen WM, Savarirayan R, Zenker M, Dallapiccola B, Gelb BD, Tartaglia M
Am J Hum Genet. 2010
PubMed ID: 20619386
Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4.
Benirschke RC, Thompson JR, Nominé Y, Wasielewski E, Juranić N, Macura S, Hatakeyama S, Nakayama KI, Botuyan MV, Mer G
Structure. 2010
PubMed ID: 20696396
Long-term survival after nonintensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of healthy persons with the mutations.
Matsuda K, Taira C, Sakashita K, Saito S, Tanaka-Yanagisawa M, Yanagisawa R, Nakazawa Y, Shiohara M, Fukushima K, Oda M, Honda T, Nakahata T, Koike K
Blood. 2010
PubMed ID: 20595524
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
Mutations of the TET2 and CBL genes: novel molecular markers in myeloid malignancies.
Bacher U, Haferlach C, Schnittger S, Kohlmann A, Kern W, Haferlach T
Ann Hematol. 2010
PubMed ID: 20195608
Mdm2 facilitates the association of p53 with the proteasome.
Kulikov R, Letienne J, Kaur M, Grossman SR, Arts J, Blattner C
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20479273
c-Cbl deficiency leads to diminished lymphocyte development and functions in an age-dependent manner.
Rathinam C, Flavell RA
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20404156
CBL mutations in juvenile myelomonocytic leukemia and pediatric myelodysplastic syndrome.
Shiba N, Kato M, Park MJ, Sanada M, Ito E, Fukushima K, Sako M, Arakawa H, Ogawa S, Hayashi Y
Leukemia. 2010
PubMed ID: 20357823
Tyrosine phosphorylation of SHIP promotes its proteasomal degradation.
Ruschmann J, Ho V, Antignano F, Kuroda E, Lam V, Ibaraki M, Snyder K, Kim C, Flavell RA, Kawakami T, Sly L, Turhan AG, Krystal G
Exp Hematol. 2010
PubMed ID: 20304029
Increased EFG- and PDGFalpha-receptor signaling by mutant FGF-receptor 2 contributes to osteoblast dysfunction in Apert craniosynostosis.
Miraoui H, Ringe J, Häupl T, Marie PJ
Hum Mol Genet. 2010
PubMed ID: 20124286
c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway.
Thien CB, Dagger SA, Steer JH, Koentgen F, Jansen ES, Scott CL, Langdon WY
J Biol Chem. 2010
PubMed ID: 20133944
Anergic CD4+ T cells form mature immunological synapses with enhanced accumulation of c-Cbl and Cbl-b.
Doherty M, Osborne DG, Browning DL, Parker DC, Wetzel SA
J Immunol. 2010
PubMed ID: 20207996
The ORF3 protein of hepatitis E virus delays degradation of activated growth factor receptors by interacting with CIN85 and blocking formation of the Cbl-CIN85 complex.
Chandra V, Kalia M, Hajela K, Jameel S
J Virol. 2010
PubMed ID: 20130058
The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors.
Kim J, Lee H, Kim Y, Yoo S, Park E, Park S
Mol Cell Biol. 2010
PubMed ID: 20100865
Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.
Ogawa S, Sanada M, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP
Cell Cycle. 2010
PubMed ID: 20237427
Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia.
Muramatsu H, Makishima H, Jankowska AM, Cazzolli H, O'Keefe C, Yoshida N, Xu Y, Nishio N, Hama A, Yagasaki H, Takahashi Y, Kato K, Manabe A, Kojima S, Maciejewski JP
Blood. 2010
PubMed ID: 20008299
Differential subcellular localization regulates c-Cbl E3 ligase activity upon Notch3 protein in T-cell leukemia.
Checquolo S, Palermo R, Cialfi S, Ferrara G, Oliviero C, Talora C, Bellavia D, Giovenco A, Grazioli P, Frati L, Gulino A, Screpanti I
Oncogene. 2010
PubMed ID: 19966856
Cbl-phosphatidylinositol 3 kinase interaction differentially regulates macrophage colony-stimulating factor-mediated osteoclast survival and cytoskeletal reorganization.
Adapala NS, Barbe MF, Langdon WY, Tsygankov AY, Sanjay A
Ann N Y Acad Sci. 2010
PubMed ID: 20392263
c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance.
Song JJ, Szczepanski MJ, Kim SY, Kim JH, An JY, Kwon YT, Alcala MA, Bartlett DL, Lee YJ
Cell Signal. 2010
PubMed ID: 19932172
c-Cbl acts as a mediator of Src-induced activation of the PI3K-Akt signal transduction pathway during TRAIL treatment.
Song JJ, Kim JH, Sun BK, Alcala MA, Bartlett DL, Lee YJ
Cell Signal. 2010
PubMed ID: 19861161
Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase.
Kim HS, Das A, Gross CC, Bryceson YT, Long EO
Immunity. 2010
PubMed ID: 20189481
c-Cbl mediated ubiquitylation and regulation of cell surface exposure of CD5.
Demydenko D
Biochem Biophys Res Commun. 2010
PubMed ID: 20085752
Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1.
Kim JH, Kim K, Jin HM, Song I, Youn BU, Lee SH, Choi Y, Kim N
J Biol Chem. 2010
PubMed ID: 20037154
Fibroblast growth factor signalling: from development to cancer.
Turner N, Grose R
Nat Rev Cancer. 2010
PubMed ID: 20094046
The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells.
Truitt L, Freywald T, DeCoteau J, Sharfe N, Freywald A
Cancer Res. 2010
PubMed ID: 20086179
Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice.
Mamchak AA, Thien CB, Dagger SA, Lyandres J, Jiang S, Langdon WY, DeFranco AL
Eur J Immunol. 2010
PubMed ID: 19904769
Interaction of c-Cbl with myosin IIA regulates Bleb associated macropinocytosis of Kaposi's sarcoma-associated herpesvirus.
Valiya Veettil M, Sadagopan S, Kerur N, Chakraborty S, Chandran B
PLoS Pathog. 2010
PubMed ID: 21203488
Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain.
Sun Q, Jackson RA, Ng C, Guy GR, Sivaraman J
PLoS One. 2010
PubMed ID: 20877636
Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias.
Rocquain J, Carbuccia N, Trouplin V, Raynaud S, Murati A, Nezri M, Tadrist Z, Olschwang S, Vey N, Birnbaum D, Gelsi-Boyer V, Mozziconacci MJ
BMC Cancer. 2010
PubMed ID: 20678218
Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
Ban HJ, Heo JY, Oh KS, Park KJ
BMC Genet. 2010
PubMed ID: 20416077
CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases.
Tan YH, Krishnaswamy S, Nandi S, Kanteti R, Vora S, Onel K, Hasina R, Lo FY, El-Hashani E, Cervantes G, Robinson M, Kales SC, Lipkowitz S, Karrison T, Sattler M, Vokes EE, Wang YC, Salgia R
PLoS One. 2010
PubMed ID: 20126411
[Expression of c-Cbl, Cbl-b, and epidermal growth factor receptor in gastric carcinoma and their clinical significance].
Dong Q, Liu YP, Qu XJ, Hou KZ, Li LL
Chin J Cancer. 2010
PubMed ID: 20038312
SHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor.
De Schutter J, Guillabert A, Imbault V, Degraef C, Erneux C, Communi D, Pirson I
J Biol Chem. 2009
PubMed ID: 19880507
Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies.
Makishima H, Cazzolli H, Szpurka H, Dunbar A, Tiu R, Huh J, Muramatsu H, O'Keefe C, Hsi E, Paquette RL, Kojima S, List AF, Sekeres MA, McDevitt MA, Maciejewski JP
J Clin Oncol. 2009
PubMed ID: 19901108
An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.
Tarcic G, Boguslavsky SK, Wakim J, Kiuchi T, Liu A, Reinitz F, Nathanson D, Takahashi T, Mischel PS, Ng T, Yarden Y
Curr Biol. 2009
PubMed ID: 19836242
Integrity of the CBL gene in mature B-cell malignancies.
McKeller MR, Robetorye RS, Dahia PL, Aguiar RC
Blood. 2009
PubMed ID: 19892728
E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.
Bandi SR, Brandts C, Rensinghoff M, Grundler R, Tickenbrock L, Köhler G, Duyster J, Berdel WE, Müller-Tidow C, Serve H, Sargin B, Study Alliance Leukemias
Blood. 2009
PubMed ID: 19734451
Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation.
Wehrle C, Van Slyke P, Dumont DJ
Biochem J. 2009
PubMed ID: 19689429
Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation.
Li Y, Qu X, Qu J, Zhang Y, Liu J, Teng Y, Hu X, Hou K, Liu Y
Cancer Lett. 2009
PubMed ID: 19457607
Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.
Kojo S, Elly C, Harada Y, Langdon WY, Kronenberg M, Liu YC
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19815501
Negative action of hepatocyte growth factor/c-Met system on angiotensin II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells.
Sanada F, Taniyama Y, Iekushi K, Azuma J, Okayama K, Kusunoki H, Koibuchi N, Doi T, Aizawa Y, Morishita R
Circ Res. 2009
PubMed ID: 19713535
c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic acid-induced cell differentiation and G0 arrest.
Shen M, Yen A
J Biol Chem. 2009
PubMed ID: 19635790
c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes.
Purev E, Neff L, Horne WC, Baron R
Mol Biol Cell. 2009
PubMed ID: 19641021
Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading.
Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T
Mol Cell Biol. 2009
PubMed ID: 19546233
Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.
Tong J, Taylor P, Peterman SM, Prakash A, Moran MF
Mol Cell Proteomics. 2009
PubMed ID: 19531499
Phosphorylation of the MET receptor on juxtamembrane tyrosine residue 1001 inhibits its caspase-dependent cleavage.
Deheuninck J, Goormachtigh G, Foveau B, Ji Z, Leroy C, Ancot F, Villeret V, Tulasne D, Fafeur V
Cell Signal. 2009
PubMed ID: 19450681
Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.
Loh ML, Sakai DS, Flotho C, Kang M, Fliegauf M, Archambeault S, Mullighan CG, Chen L, Bergstraesser E, Bueso-Ramos CE, Emanuel PD, Hasle H, Issa JP, van den Heuvel-Eibrink MM, Locatelli F, Stary J, Trebo M, Wlodarski M, Zecca M, Shannon KM, Niemeyer CM
Blood. 2009
PubMed ID: 19571318
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S
Nature. 2009
PubMed ID: 19620960
A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis.
Kundu M, Pathak SK, Kumawat K, Basu S, Chatterjee G, Pathak S, Noguchi T, Takeda K, Ichijo H, Thien CB, Langdon WY, Basu J
Nat Immunol. 2009
PubMed ID: 19597496
Cbl negatively regulates JNK activation and cell death.
Sproul AA, Xu Z, Wilhelm M, Gire S, Greene LA
Cell Res. 2009
PubMed ID: 19546888
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG, Smith RD, Wiley HS, Qian WJ
J Proteome Res. 2009
PubMed ID: 19534553
Reciprocal regulation of the ubiquitin ligase Itch and the epidermal growth factor receptor signaling.
Azakir BA, Angers A
Cell Signal. 2009
PubMed ID: 19341794
Syk tyrosine 317 negatively regulates osteoclast function via the ubiquitin-protein isopeptide ligase activity of Cbl.
Zou W, Reeve JL, Zhao H, Ross FP, Teitelbaum SL
J Biol Chem. 2009
PubMed ID: 19419964
The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl.
Sekine Y, Yamamoto C, Ikeda O, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T
Biochem Biophys Res Commun. 2009
PubMed ID: 19401194
Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms.
Grand FH, Hidalgo-Curtis CE, Ernst T, Zoi K, Zoi C, McGuire C, Kreil S, Jones A, Score J, Metzgeroth G, Oscier D, Hall A, Brandts C, Serve H, Reiter A, Chase AJ, Cross NC
Blood. 2009
PubMed ID: 19387008
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding.
Dale BM, Traum D, Erdjument-Bromage H, Tempst P, Greenberg S
J Immunol. 2009
PubMed ID: 19380812
Knockdown of GnT-Va expression inhibits ligand-induced downregulation of the epidermal growth factor receptor and intracellular signaling by inhibiting receptor endocytosis.
Guo HB, Johnson H, Randolph M, Lee I, Pierce M
Glycobiology. 2009
PubMed ID: 19225046
The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction.
Sun J, Pedersen M, Rönnstrand L
J Biol Chem. 2009
PubMed ID: 19265199
Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications.
Ababou A, Pfuhl M, Ladbury JE
J Mol Biol. 2009
PubMed ID: 19268472
CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes.
Reindl C, Quentmeier H, Petropoulos K, Greif PA, Benthaus T, Argiropoulos B, Mellert G, Vempati S, Duyster J, Buske C, Bohlander SK, Humphries KR, Hiddemann W, Spiekermann K
Clin Cancer Res. 2009
PubMed ID: 19276253
Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.
Chan W, Tian R, Lee YF, Sit ST, Lim L, Manser E
J Biol Chem. 2009
PubMed ID: 19144635
The phytochemical piceatannol induces the loss of CBL and CBL-associated proteins.
Klimowicz AC, Bisson SA, Hans K, Long EM, Hansen HC, Robbins SM
Mol Cancer Ther. 2009
PubMed ID: 19258424
The c-Cbl proto-oncoprotein downregulates EBV LMP2A signaling.
Ikeda M, Longnecker R
Virology. 2009
PubMed ID: 19081591
The ubiquitin ligase c-Cbl down-regulates FcgammaRIIa activation in human neutrophils.
Marois L, Vaillancourt M, Marois S, Proulx S, Paré G, Rollet-Labelle E, Naccache PH
J Immunol. 2009
PubMed ID: 19201892
Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation.
Chiang YJ, Jordan MS, Horai R, Schwartzberg PL, Koretzky GA, Hodes RJ
J Biol Chem. 2009
PubMed ID: 19074136
[Effects of Bufalin on SYK and CBL family proteins in induction of HL-60 cell apoptosis].
Qu XJ, Zhao MF, Liu YP, Teng YE, Qu JL, Zhang Y, Xu L, Li YC, Hou KZ
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009
PubMed ID: 19236749
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
Cell. 2009
PubMed ID: 19167335
Cbl controls EGFR fate by regulating early endosome fusion.
Visser Smit GD, Place TL, Cole SL, Clausen KA, Vemuganti S, Zhang G, Koland JG, Lill NL
Sci Signal. 2009
PubMed ID: 20029031
A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice.
Johnson KJ, Griswold IJ, O'Hare T, Corbin AS, Loriaux M, Deininger MW, Druker BJ
PLoS One. 2009
PubMed ID: 19823681
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies.
Dunbar AJ, Gondek LP, O'Keefe CL, Makishima H, Rataul MS, Szpurka H, Sekeres MA, Wang XF, McDevitt MA, Maciejewski JP
Cancer Res. 2008
PubMed ID: 19074904
TEAD1 and c-Cbl are novel prostate basal cell markers that correlate with poor clinical outcome in prostate cancer.
Knight JF, Shepherd CJ, Rizzo S, Brewer D, Jhavar S, Dodson AR, Cooper CS, Eeles R, Falconer A, Kovacs G, Garrett MD, Norman AR, Shipley J, Hudson DL
Br J Cancer. 2008
PubMed ID: 19002168
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Reduced Cbl phosphorylation and degradation of the zeta-chain of the T-cell receptor/CD3 complex in T cells with low Lck levels.
Methi T, Berge T, Torgersen KM, Taskén K
Eur J Immunol. 2008
PubMed ID: 18792408
Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.
Slape C, Liu LY, Beachy S, Aplan PD
Blood. 2008
PubMed ID: 18566322
Suppression of c-Cbl tyrosine phosphorylation inhibits neointimal formation in balloon-injured rat arteries.
Tang Z, Wang Y, Fan Y, Zhu Y, Chien S, Wang N
Circulation. 2008
PubMed ID: 18663086
c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130.
Tanaka Y, Tanaka N, Saeki Y, Tanaka K, Murakami M, Hirano T, Ishii N, Sugamura K
Mol Cell Biol. 2008
PubMed ID: 18519587
Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation.
Umebayashi K, Stenmark H, Yoshimori T
Mol Biol Cell. 2008
PubMed ID: 18508924
c-Cbl expression levels regulate the functional responses of human central and effector memory CD4 T cells.
Brembilla NC, Weber J, Rimoldi D, Pradervand S, Schütz F, Pantaleo G, Rüegg C, Quadroni M, Harshman K, Doucey MA
Blood. 2008
PubMed ID: 18505781
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis.
Sehat B, Andersson S, Girnita L, Larsson O
Cancer Res. 2008
PubMed ID: 18632619
FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival.
Dufour C, Guenou H, Kaabeche K, Bouvard D, Sanjay A, Marie PJ
Bone. 2008
PubMed ID: 18374639
A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation.
Pennock S, Wang Z
Mol Cell Biol. 2008
PubMed ID: 18316398
The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells.
Rathinam C, Thien CB, Langdon WY, Gu H, Flavell RA
Genes Dev. 2008
PubMed ID: 18413713
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins.
Choi EY, Orlova VV, Fagerholm SC, Nurmi SM, Zhang L, Ballantyne CM, Gahmberg CG, Chavakis T
Blood. 2008
PubMed ID: 18239087
Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.
Wu J, Meng F, Lu H, Kong L, Bornmann W, Peng Z, Talpaz M, Donato NJ
Blood. 2008
PubMed ID: 18235045
EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate.
Stern KA, Place TL, Lill NL
Biochem J. 2008
PubMed ID: 18045238
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates.
Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J
EMBO J. 2008
PubMed ID: 18273061
The Met tyrosine kinase receptor in development and cancer.
Gentile A, Trusolino L, Comoglio PM
Cancer Metastasis Rev. 2008
PubMed ID: 18175071
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Epidermal growth factor receptor exposed to cigarette smoke is aberrantly activated and undergoes perinuclear trafficking.
Khan EM, Lanir R, Danielson AR, Goldkorn T
FASEB J. 2008
PubMed ID: 17971399
A novel role of Sprouty 2 in regulating cellular apoptosis.
Edwin F, Patel TB
J Biol Chem. 2008
PubMed ID: 18070883
Phosphorylated ITIMs enable ubiquitylation of an inhibitory cell surface receptor.
Walter RB, Häusermann P, Raden BW, Teckchandani AM, Kamikura DM, Bernstein ID, Cooper JA
Traffic. 2008
PubMed ID: 18062779
Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.
Fasen K, Cerretti DP, Huynh-Do U
Traffic. 2008
PubMed ID: 18034775
Neural cell adhesion molecule-180-mediated homophilic binding induces epidermal growth factor receptor (EGFR) down-regulation and uncouples the inhibitory function of EGFR in neurite outgrowth.
Povlsen GK, Berezin V, Bock E
J Neurochem. 2008
PubMed ID: 17995934
Evidence that sprouty 2 is necessary for sarcoma formation by H-Ras oncogene-transformed human fibroblasts.
Lito P, Mets BD, Kleff S, O'Reilly S, Maher VM, McCormick JJ
J Biol Chem. 2008
PubMed ID: 18048363
Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.
Chandramouli S, Yu CY, Yusoff P, Lao DH, Leong HF, Mizuno K, Guy GR
J Biol Chem. 2008
PubMed ID: 17974561
Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein.
Usui R, Shibuya M, Ishibashi S, Maru Y
EMBO Rep. 2007
PubMed ID: 17962812
c-Cbl-mediated regulation of LAT-nucleated signaling complexes.
Balagopalan L, Barr VA, Sommers CL, Barda-Saad M, Goyal A, Isakowitz MS, Samelson LE
Mol Cell Biol. 2007
PubMed ID: 17938199
c-Cbl is not required for ERK1/2-dependent degradation of BimEL.
Wiggins CM, Band H, Cook SJ
Cell Signal. 2007
PubMed ID: 17884340
Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
Cao L, Yu K, Banh C, Nguyen V, Ritz A, Raphael BJ, Kawakami Y, Kawakami T, Salomon AR
J Immunol. 2007
PubMed ID: 17947660
Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl.
Sun J, Pedersen M, Bengtsson S, Rönnstrand L
Exp Cell Res. 2007
PubMed ID: 17904548
Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.
Shtiegman K, Kochupurakkal BS, Zwang Y, Pines G, Starr A, Vexler A, Citri A, Katz M, Lavi S, Ben-Basat Y, Benjamin S, Corso S, Gan J, Yosef RB, Giordano S, Yarden Y
Oncogene. 2007
PubMed ID: 17486068
T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis.
Collingwood TS, Smirnova EV, Bogush M, Carpino N, Annan RS, Tsygankov AY
J Biol Chem. 2007
PubMed ID: 17709377
Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function.
Bernatchez PN, Acevedo L, Fernandez-Hernando C, Murata T, Chalouni C, Kim J, Erdjument-Bromage H, Shah V, Gratton JP, McNally EM, Tempst P, Sessa WC
J Biol Chem. 2007
PubMed ID: 17702744
Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.
Reddi AL, Ying G, Duan L, Chen G, Dimri M, Douillard P, Druker BJ, Naramura M, Band V, Band H
J Biol Chem. 2007
PubMed ID: 17620338
Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase.
Kozlov G, Peschard P, Zimmerman B, Lin T, Moldoveanu T, Mansur-Azzam N, Gehring K, Park M
J Biol Chem. 2007
PubMed ID: 17635922
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase.
Sekine Y, Tsuji S, Ikeda O, Sugiyma K, Oritani K, Shimoda K, Muromoto R, Ohbayashi N, Yoshimura A, Matsuda T
J Immunol. 2007
PubMed ID: 17675501
The adaptor molecule CIN85 regulates Syk tyrosine kinase level by activating the ubiquitin-proteasome degradation pathway.
Peruzzi G, Molfetta R, Gasparrini F, Vian L, Morrone S, Piccoli M, Frati L, Santoni A, Paolini R
J Immunol. 2007
PubMed ID: 17675467
Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b.
Peschard P, Kozlov G, Lin T, Mirza IA, Berghuis AM, Lipkowitz S, Park M, Gehring K
Mol Cell. 2007
PubMed ID: 17679095
Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia.
Caligiuri MA, Briesewitz R, Yu J, Wang L, Wei M, Arnoczky KJ, Marburger TB, Wen J, Perrotti D, Bloomfield CD, Whitman SP
Blood. 2007
PubMed ID: 17475912
GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor.
Su X, Kong C, Stahl PD
J Biol Chem. 2007
PubMed ID: 17545148
EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes.
Grandal MV, Zandi R, Pedersen MW, Willumsen BM, van Deurs B, Poulsen HS
Carcinogenesis. 2007
PubMed ID: 17372273
The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation.
Pakuts B, Debonneville C, Liontos LM, Loreto MP, McGlade CJ
J Biol Chem. 2007
PubMed ID: 17353186
c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are regulated by membrane association of c-Cbl.
Swaminathan G, Feshchenko EA, Tsygankov AY
Oncogene. 2007
PubMed ID: 17237826
Is the c-Cbl proto-oncogene involved in chronic lymphocytic leukemia?
Mankaï A, Eveillard JR, Buhé V, Le Ster K, Loisel S, Ghedira I, Youinou P, Berthou C, Bordron A
Ann N Y Acad Sci. 2007
PubMed ID: 17804547
The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor.
Bonaventure J, Gibbs L, Horne WC, Baron R
FEBS J. 2007
PubMed ID: 17509076
Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b.
Kitaura Y, Jang IK, Wang Y, Han YC, Inazu T, Cadera EJ, Schlissel M, Hardy RR, Gu H
Immunity. 2007
PubMed ID: 17493844
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks.
Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17389395
A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis.
Singh AJ, Meyer RD, Navruzbekov G, Shelke R, Duan L, Band H, Leeman SE, Rahimi N
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17372230
CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery.
Nam JM, Onodera Y, Mazaki Y, Miyoshi H, Hashimoto S, Sabe H
EMBO J. 2007
PubMed ID: 17255943
Altered endocytosis of epidermal growth factor receptor in androgen receptor positive prostate cancer cell lines.
Bonaccorsi L, Nosi D, Muratori M, Formigli L, Forti G, Baldi E
J Mol Endocrinol. 2007
PubMed ID: 17242169
Redundancy in B cell developmental pathways: c-Cbl inactivation rescues early B cell development through a B cell linker protein-independent pathway.
Song H, Zhang J, Chiang YJ, Siraganian RP, Hodes RJ
J Immunol. 2007
PubMed ID: 17202354
Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination.
Lock P, I ST, Straffon AF, Schieb H, Hovens CM, Stylli SS
Biochem Biophys Res Commun. 2006
PubMed ID: 17094949
PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases.
Vantler M, Huntgeburth M, Caglayan E, Ten Freyhaus H, Schnabel P, Rosenkranz S
FEBS Lett. 2006
PubMed ID: 17141222
Alix facilitates the interaction between c-Cbl and platelet-derived growth factor beta-receptor and thereby modulates receptor down-regulation.
Lennartsson J, Wardega P, Engström U, Hellman U, Heldin CH
J Biol Chem. 2006
PubMed ID: 17082185
p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration.
Frey MR, Dise RS, Edelblum KL, Polk DB
EMBO J. 2006
PubMed ID: 17139251
Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action.
Molero JC, Turner N, Thien CB, Langdon WY, James DE, Cooney GJ
Diabetes. 2006
PubMed ID: 17130487
Detection in primary chronic myeloid leukaemia cells of p210BCR-ABL1 in complexes with adaptor proteins CBL, CRKL, and GRB2.
Patel H, Marley SB, Gordon MY
Genes Chromosomes Cancer. 2006
PubMed ID: 16955467
Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.
Dragone LL, Myers MD, White C, Gadwal S, Sosinowski T, Gu H, Weiss A
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17110436
Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells.
Gustin SE, Thien CB, Langdon WY
J Immunol. 2006
PubMed ID: 17056522
Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling.
Martin NP, Mohney RP, Dunn S, Das M, Scappini E, O'Bryan JP
Mol Pharmacol. 2006
PubMed ID: 16914641
Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteins.
Huang F, Kitaura Y, Jang I, Naramura M, Kole HH, Liu L, Qin H, Schlissel MS, Gu H
Immunity. 2006
PubMed ID: 17045823
Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation.
Guenou H, Kaabeche K, Dufour C, Miraoui H, Marie PJ
Am J Pathol. 2006
PubMed ID: 17003487
Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII.
Han W, Zhang T, Yu H, Foulke JG, Tang CK
Cancer Biol Ther. 2006
PubMed ID: 16969069
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP
Nat Biotechnol. 2006
PubMed ID: 16964243
Identification of 14-3-3epsilon substrates from embryonic murine brain.
Ballif BA, Cao Z, Schwartz D, Carraway KL, Gygi SP
J Proteome Res. 2006
PubMed ID: 16944949
Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling.
Germano S, Barberis D, Santoro MM, Penengo L, Citri A, Yarden Y, Gaudino G
J Biol Chem. 2006
PubMed ID: 16740632
Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases.
Oved S, Mosesson Y, Zwang Y, Santonico E, Shtiegman K, Marmor MD, Kochupurakkal BS, Katz M, Lavi S, Cesareni G, Yarden Y
J Biol Chem. 2006
PubMed ID: 16735510
Cbl and Akt regulate CXCL8-induced and CXCR1- and CXCR2-mediated chemotaxis.
Lane HC, Anand AR, Ganju RK
Int Immunol. 2006
PubMed ID: 16798838
Activation of Epstein-Barr virus/C3d receptor (gp140, CR2, CD21) on human B lymphoma cell surface triggers Cbl tyrosine phosphorylation, its association with p85 subunit, Crk-L and Syk and its dissociation with Vav.
Lottin-Divoux S, Jean D, Le Romancer M, Frade R
Cell Signal. 2006
PubMed ID: 16289966
A germline-specific class of small RNAs binds mammalian Piwi proteins.
Girard A, Sachidanandam R, Hannon GJ, Carmell MA
Nature. 2006
PubMed ID: 16751776
EGF-ERBB signalling: towards the systems level.
Citri A, Yarden Y
Nat Rev Mol Cell Biol. 2006
PubMed ID: 16829981
Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix.
Schmidt MH, Husnjak K, Szymkiewicz I, Haglund K, Dikic I
Oncogene. 2006
PubMed ID: 16407834
Activation of the Cbl insulin signaling pathway in cardiac muscle; dysregulation in obesity and diabetes.
Gupte A, Mora S
Biochem Biophys Res Commun. 2006
PubMed ID: 16494846
Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells.
Fecchi K, Volonte D, Hezel MP, Schmeck K, Galbiati F
FASEB J. 2006
PubMed ID: 16455755
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
Nature. 2006
PubMed ID: 16554811
Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation.
Pierchala BA, Milbrandt J, Johnson EM
J Neurosci. 2006
PubMed ID: 16525057
Casitas b-lineage lymphoma-deficient mice are protected against high-fat diet-induced obesity and insulin resistance.
Molero JC, Waring SG, Cooper A, Turner N, Laybutt R, Cooney GJ, James DE
Diabetes. 2006
PubMed ID: 16505234
Stromal-cell-derived factor-1/CXCL12-induced chemotaxis of a T cell line involves intracellular signaling through Cbl and Cbl-b and their regulation by Src kinases and CD45.
Okabe S, Tauchi T, Ohyashiki K, Broxmeyer HE
Blood Cells Mol Dis. 2006
PubMed ID: 16503409
Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains.
Braiman A, Barda-Saad M, Sommers CL, Samelson LE
EMBO J. 2006
PubMed ID: 16467851
Somatic mutations lead to an oncogenic deletion of met in lung cancer.
Kong-Beltran M, Seshagiri S, Zha J, Zhu W, Bhawe K, Mendoza N, Holcomb T, Pujara K, Stinson J, Fu L, Severin C, Rangell L, Schwall R, Amler L, Wickramasinghe D, Yauch R
Cancer Res. 2006
PubMed ID: 16397241
Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex.
Myers MD, Sosinowski T, Dragone LL, White C, Band H, Gu H, Weiss A
Nat Immunol. 2006
PubMed ID: 16327786
The Cbl RING finger C-terminal flank controls epidermal growth factor receptor fate downstream of receptor ubiquitination.
Visser GD, Lill NL
Exp Cell Res. 2005
PubMed ID: 16246327
Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.
Simmons A, Gangadharan B, Hodges A, Sharrocks K, Prabhakar S, García A, Dwek R, Zitzmann N, McMichael A
Immunity. 2005
PubMed ID: 16356860
Decreased insulin-dependent glucose transport by chronic ethanol feeding is associated with dysregulation of the Cbl/TC10 pathway in rat adipocytes.
Sebastian BM, Nagy LE
Am J Physiol Endocrinol Metab. 2005
PubMed ID: 16105861
Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl.
El Chami N, Ikhlef F, Kaszas K, Yakoub S, Tabone E, Siddeek B, Cunha S, Beaudoin C, Morel L, Benahmed M, Régnier DC
J Cell Biol. 2005
PubMed ID: 16301331
Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.
Roskoski R
Biochem Biophys Res Commun. 2005
PubMed ID: 16129412
Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.
Thien CB, Blystad FD, Zhan Y, Lew AM, Voigt V, Andoniou CE, Langdon WY
EMBO J. 2005
PubMed ID: 16211006
Cbl promotes clustering of endocytic adaptor proteins.
Jozic D, Cárdenes N, Deribe YL, Moncalián G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J
Nat Struct Mol Biol. 2005
PubMed ID: 16228008
A role of the protein Cbl in FGF-2-induced angiogenesis in murine brain endothelial cells.
Holmqvist K, Welsh M, Lu L
Cell Signal. 2005
PubMed ID: 16125056
Intrinsic regulation of the interactions between the SH3 domain of p85 subunit of phosphatidylinositol-3 kinase and the protein network of BCR/ABL oncogenic tyrosine kinase.
Ren SY, Xue F, Feng J, Skorski T
Exp Hematol. 2005
PubMed ID: 16219545
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
A novel dileucine lysosomal-sorting-signal mediates intracellular EGF-receptor retention independently of protein ubiquitylation.
Tsacoumangos A, Tsacoumango A, Kil SJ, Ma L, Sönnichsen FD, Carlin C
J Cell Sci. 2005
PubMed ID: 16105874
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.
Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM
Mol Cell Proteomics. 2005
PubMed ID: 15951569
Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.
Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, Watts JD, Hood L, Aebersold R
Nat Methods. 2005
PubMed ID: 16094384
Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation.
Valverde P
Biochem Biophys Res Commun. 2005
PubMed ID: 15958209
Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation.
Haglund K, Schmidt MH, Wong ES, Guy GR, Dikic I
EMBO Rep. 2005
PubMed ID: 15962011
Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity.
Bruzzaniti A, Neff L, Sanjay A, Horne WC, De Camilli P, Baron R
Mol Biol Cell. 2005
PubMed ID: 15872089
Nef enhances c-Cbl phosphorylation in HIV-infected CD4+ T lymphocytes.
Yang P, Henderson AJ
Virology. 2005
PubMed ID: 15892963
The multidomain protooncogenic protein c-Cbl binds to tubulin and stabilizes microtubules.
Teckchandani AM, Birukova AA, Tar K, Verin AD, Tsygankov AY
Exp Cell Res. 2005
PubMed ID: 15878338
Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins.
Hu J, Hubbard SR
J Biol Chem. 2005
PubMed ID: 15737992
c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2.
Jacob C, Cottrell GS, Gehringer D, Schmidlin F, Grady EF, Bunnett NW
J Biol Chem. 2005
PubMed ID: 15708858
Herpes simplex virus 1 infected cell protein 0 forms a complex with CIN85 and Cbl and mediates the degradation of EGF receptor from cell surfaces.
Liang Y, Kurakin A, Roizman B
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15824310
Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase.
Scott RP, Eketjäll S, Aineskog H, Ibáñez CF
J Biol Chem. 2005
PubMed ID: 15677445
HPV16 E5 protein disrupts the c-Cbl-EGFR interaction and EGFR ubiquitination in human foreskin keratinocytes.
Zhang B, Srirangam A, Potter DA, Roman A
Oncogene. 2005
PubMed ID: 15735736
SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor.
Prasad NK, Decker SJ
J Biol Chem. 2005
PubMed ID: 15668240
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.
Thelemann A, Petti F, Griffin G, Iwata K, Hunt T, Settinari T, Fenyo D, Gibson N, Haley JD
Mol Cell Proteomics. 2005
PubMed ID: 15657067
Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation.
Kaabeche K, Guenou H, Bouvard D, Didelot N, Listrat A, Marie PJ
J Cell Sci. 2005
PubMed ID: 15728256
TGF-beta, c-Cbl, and PDGFR-alpha the in mammary stroma.
Crowley MR, Bowtell D, Serra R
Dev Biol. 2005
PubMed ID: 15708558
Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis.
Huang F, Sorkin A
Mol Biol Cell. 2005
PubMed ID: 15635092
Phosphotyrosine interactome of the ErbB-receptor kinase family.
Schulze WX, Deng L, Mann M
Mol Syst Biol. 2005
PubMed ID: 16729043
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ
Nat Biotechnol. 2005
PubMed ID: 15592455
Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).
Zeng S, Xu Z, Lipkowitz S, Longley JB
Blood. 2005
PubMed ID: 15315962
Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment.
de Melker AA, van der Horst G, Borst J
J Biol Chem. 2004
PubMed ID: 15465819
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
Three-chromophore FRET microscopy to analyze multiprotein interactions in living cells.
Galperin E, Verkhusha VV, Sorkin A
Nat Methods. 2004
PubMed ID: 15782196
Loss of syk kinase during IgE-mediated stimulation of human basophils.
Macglashan D, Miura K
J Allergy Clin Immunol. 2004
PubMed ID: 15577829
Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl.
Grossmann AH, Kolibaba KS, Willis SG, Corbin AS, Langdon WS, Deininger MW, Druker BJ
FEBS Lett. 2004
PubMed ID: 15556646
c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action.
Molero JC, Jensen TE, Withers PC, Couzens M, Herzog H, Thien CB, Langdon WY, Walder K, Murphy MA, Bowtell DD, James DE, Cooney GJ
J Clin Invest. 2004
PubMed ID: 15520865
Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation.
Grøvdal LM, Stang E, Sorkin A, Madshus IH
Exp Cell Res. 2004
PubMed ID: 15475003
c-Cbl binds to tyrosine-phosphorylated neurotrophin receptor p75 and induces its ubiquitination.
Ohrt T, Mancini A, Tamura T, Niedenthal R
Cell Signal. 2004
PubMed ID: 15337528
Differential regulation of the B cell receptor-mediated signaling by the E3 ubiquitin ligase Cbl.
Shao Y, Yang C, Elly C, Liu YC
J Biol Chem. 2004
PubMed ID: 15304502
Signal transduction via the stem cell factor receptor/c-Kit.
Rönnstrand L
Cell Mol Life Sci. 2004
PubMed ID: 15526160
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex.
Schmidt MH, Hoeller D, Yu J, Furnari FB, Cavenee WK, Dikic I, Bögler O
Mol Cell Biol. 2004
PubMed ID: 15456872
c-Cbl directs EGF receptors into an endocytic pathway that involves the ubiquitin-interacting motif of Eps15.
de Melker AA, van der Horst G, Borst J
J Cell Sci. 2004
PubMed ID: 15383614
Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b.
Davies GC, Ettenberg SA, Coats AO, Mussante M, Ravichandran S, Collins J, Nau MM, Lipkowitz S
Oncogene. 2004
PubMed ID: 15273720
RNAi-based analysis of CAP, Cbl, and CrkII function in the regulation of GLUT4 by insulin.
Mitra P, Zheng X, Czech MP
J Biol Chem. 2004
PubMed ID: 15258163
Purification and identification of protein-tyrosine kinase-binding proteins using synthetic phosphopeptides as affinity reagents.
Wilhelmsen K, Copp J, Glenn G, Hoffman RC, Tucker P, van der Geer P
Mol Cell Proteomics. 2004
PubMed ID: 15215307
c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomes.
Ravid T, Heidinger JM, Gee P, Khan EM, Goldkorn T
J Biol Chem. 2004
PubMed ID: 15210722
Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation.
Kaabeche K, Lemonnier J, Le Mée S, Caverzasio J, Marie PJ
J Biol Chem. 2004
PubMed ID: 15190072
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T
Curr Biol. 2004
PubMed ID: 15324660
Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase.
Ghosh AK, Reddi AL, Rao NL, Duan L, Band V, Band H
J Biol Chem. 2004
PubMed ID: 15208330
LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation.
Gur G, Rubin C, Katz M, Amit I, Citri A, Nilsson J, Amariglio N, Henriksson R, Rechavi G, Hedman H, Wides R, Yarden Y
EMBO J. 2004
PubMed ID: 15282549
Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor.
Zhang J, Chiang YJ, Hodes RJ, Siraganian RP
J Immunol. 2004
PubMed ID: 15265912
Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.
Kowanetz K, Crosetto N, Haglund K, Schmidt MH, Heldin CH, Dikic I
J Biol Chem. 2004
PubMed ID: 15159412
A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation.
Peschard P, Ishiyama N, Lin T, Lipkowitz S, Park M
J Biol Chem. 2004
PubMed ID: 15123609
Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice.
Chiang YJ, Sommers CL, Jordan MS, Gu H, Samelson LE, Koretzky GA, Hodes RJ
J Exp Med. 2004
PubMed ID: 15238603
ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.
Motegi A, Fujimoto J, Kotani M, Sakuraba H, Yamamoto T
J Cell Sci. 2004
PubMed ID: 15226403
TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin.
Feshchenko EA, Smirnova EV, Swaminathan G, Teckchandani AM, Agrawal R, Band H, Zhang X, Annan RS, Carr SA, Tsygankov AY
Oncogene. 2004
PubMed ID: 15107835
Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites.
Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I
J Cell Sci. 2004
PubMed ID: 15128873
Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling.
Ahn MY, Katsanakis KD, Bheda F, Pillay TS
J Biol Chem. 2004
PubMed ID: 15031295
SH3P2 in complex with Cbl and Src.
Szymkiewicz I, Destaing O, Jurdic P, Dikic I
FEBS Lett. 2004
PubMed ID: 15135048
The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1).
Kobayashi S, Sawano A, Nojima Y, Shibuya M, Maru Y
FASEB J. 2004
PubMed ID: 15001553
Src kinase activity is essential for osteoclast function.
Miyazaki T, Sanjay A, Neff L, Tanaka S, Horne WC, Baron R
J Biol Chem. 2004
PubMed ID: 14739300
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.
Akiyama T, Bouillet P, Miyazaki T, Kadono Y, Chikuda H, Chung UI, Fukuda A, Hikita A, Seto H, Okada T, Inaba T, Sanjay A, Baron R, Kawaguchi H, Oda H, Nakamura K, Strasser A, Tanaka S
EMBO J. 2003
PubMed ID: 14657036
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Aberrant expression of HOXA9, DEK, CBL and CSF1R in acute myeloid leukemia.
Casas S, Nagy B, Elonen E, Aventín A, Larramendy ML, Sierra J, Ruutu T, Knuutila S
Leuk Lymphoma. 2003
PubMed ID: 14738146
c-Cbl negatively regulates platelet activation by glycoprotein VI.
Auger JM, Best D, Snell DC, Wilde JI, Watson SP
J Thromb Haemost. 2003
PubMed ID: 14629478
Cbl-mediated ubiquitinylation and negative regulation of Vav.
Miura-Shimura Y, Duan L, Rao NL, Reddi AL, Shimura H, Rottapel R, Druker BJ, Tsygankov A, Band V, Band H
J Biol Chem. 2003
PubMed ID: 12881521
Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation.
Wu WJ, Tu S, Cerione RA
Cell. 2003
PubMed ID: 14505571
The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport.
Liu J, DeYoung SM, Hwang JB, O'Leary EE, Saltiel AR
J Biol Chem. 2003
PubMed ID: 12842890
Deletion of the gene encoding c-Cbl alters the ability of osteoclasts to migrate, delaying resorption and ossification of cartilage during the development of long bones.
Chiusaroli R, Sanjay A, Henriksen K, Engsig MT, Horne WC, Gu H, Baron R
Dev Biol. 2003
PubMed ID: 14499658
Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function.
Fong CW, Leong HF, Wong ES, Lim J, Yusoff P, Guy GR
J Biol Chem. 2003
PubMed ID: 12815057
The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.
Flanders JA, Feng Q, Bagrodia S, Laux MT, Singavarapu A, Cerione RA
FEBS Lett. 2003
PubMed ID: 12935897
Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation.
Jiang X, Sorkin A
Traffic. 2003
PubMed ID: 12839496
Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis.
Duan L, Miura Y, Dimri M, Majumder B, Dodge IL, Reddi AL, Ghosh A, Fernandes N, Zhou P, Mullane-Robinson K, Rao N, Donoghue S, Rogers RA, Bowtell D, Naramura M, Gu H, Band V, Band H
J Biol Chem. 2003
PubMed ID: 12754251
Ephrin-A1 induces c-Cbl phosphorylation and EphA receptor down-regulation in T cells.
Sharfe N, Freywald A, Toro A, Roifman CM
J Immunol. 2003
PubMed ID: 12794130
c-Cbl is a critical modulator of the Ron tyrosine kinase receptor.
Penengo L, Rubin C, Yarden Y, Gaudino G
Oncogene. 2003
PubMed ID: 12802274
Identification of CBL, a proto-oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemia.
Fu JF, Hsu JJ, Tang TC, Shih LY
Genes Chromosomes Cancer. 2003
PubMed ID: 12696071
Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells.
Duval M, Bédard-Goulet S, Delisle C, Gratton JP
J Biol Chem. 2003
PubMed ID: 12649282
Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization.
Schmidt MH, Furnari FB, Cavenee WK, Bögler O
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12734385
CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis.
Deregibus MC, Buttiglieri S, Russo S, Bussolati B, Camussi G
J Biol Chem. 2003
PubMed ID: 12637493
PP1 inhibitor induces degradation of RETMEN2A and RETMEN2B oncoproteins through proteosomal targeting.
Carniti C, Perego C, Mondellini P, Pierotti MA, Bongarzone I
Cancer Res. 2003
PubMed ID: 12727845
Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl.
Niederberger N, Holmberg K, Alam SM, Sakati W, Naramura M, Gu H, Gascoigne NR
J Immunol. 2003
PubMed ID: 12707333
Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement.
Caveggion E, Continolo S, Pixley FJ, Stanley ER, Bowtell DD, Lowell CA, Berton G
J Cell Physiol. 2003
PubMed ID: 12652654
Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase.
Shao Y, Elly C, Liu YC
EMBO Rep. 2003
PubMed ID: 12671687
Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptors.
Bao J, Gur G, Yarden Y
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12604776
CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities.
Tibaldi EV, Reinherz EL
Int Immunol. 2003
PubMed ID: 12618476
Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils.
Melander F, Andersson T, Dib K
Biochem J. 2003
PubMed ID: 12435267
hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl.
Hall AB, Jura N, DaSilva J, Jang YJ, Gong D, Bar-Sagi D
Curr Biol. 2003
PubMed ID: 12593796
Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops.
Rubin C, Litvak V, Medvedovsky H, Zwang Y, Lev S, Yarden Y
Curr Biol. 2003
PubMed ID: 12593795
A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase.
Thien CB, Scaife RM, Papadimitriou JM, Murphy MA, Bowtell DD, Langdon WY
J Exp Med. 2003
PubMed ID: 12591907
Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.
Soubeyran P, Barac A, Szymkiewicz I, Dikic I
Biochem J. 2003
PubMed ID: 12475393
CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl.
Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y
Traffic. 2003
PubMed ID: 12559036
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12522270
The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2.
Vandenbroere I, Paternotte N, Dumont JE, Erneux C, Pirson I
Biochem Biophys Res Commun. 2003
PubMed ID: 12504111
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.
Brdicka T, Imrich M, Angelisová P, Brdicková N, Horváth O, Spicka J, Hilgert I, Lusková P, Dráber P, Novák P, Engels N, Wienands J, Simeoni L, Osterreicher J, Aguado E, Malissen M, Schraven B, Horejsí V
J Exp Med. 2002
PubMed ID: 12486104
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation.
Naramura M, Jang IK, Kole H, Huang F, Haines D, Gu H
Nat Immunol. 2002
PubMed ID: 12415267
Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH.
Courbard JR, Fiore F, Adélaïde J, Borg JP, Birnbaum D, Ollendorff V
J Biol Chem. 2002
PubMed ID: 12226085
c-Cbl-dependent EphA2 protein degradation is induced by ligand binding.
Walker-Daniels J, Riese DJ, Kinch MS
Mol Cancer Res. 2002
PubMed ID: 12496371
CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.
Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I
J Biol Chem. 2002
PubMed ID: 12177062
c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination.
Taher TE, Tjin EP, Beuling EA, Borst J, Spaargaren M, Pals ST
J Immunol. 2002
PubMed ID: 12244174
Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.
Haglund K, Shimokawa N, Szymkiewicz I, Dikic I
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12218189
Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.
Wong ES, Fong CW, Lim J, Yusoff P, Low BC, Langdon WY, Guy GR
EMBO J. 2002
PubMed ID: 12234920
c-Cbl is a negative regulator of GH-stimulated STAT5-mediated transcription.
Goh EL, Zhu T, Leong WY, Lobie PE
Endocrinology. 2002
PubMed ID: 12193575
SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.
Kant AM, De P, Peng X, Yi T, Rawlings DJ, Kim JS, Durden DL
Blood. 2002
PubMed ID: 12176909
Repression of c-Cbl leads to enhanced G-CSF Jak-STAT signaling without increased cell proliferation.
Wang L, Rudert WA, Loutaev I, Roginskaya V, Corey SJ
Oncogene. 2002
PubMed ID: 12149655
Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6.
Kameya S, Hawes NL, Chang B, Heckenlively JR, Naggert JK, Nishina PM
Hum Mol Genet. 2002
PubMed ID: 12140190
Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor.
Kassenbrock CK, Hunter S, Garl P, Johnson GL, Anderson SM
J Biol Chem. 2002
PubMed ID: 11994282
Ruk is ubiquitinated but not degraded by the proteasome.
Verdier F, Valovka T, Zhyvoloup A, Drobot LB, Buchman V, Waterfield M, Gout I
Eur J Biochem. 2002
PubMed ID: 12135478
EGF-dependent association of phospholipase C-gamma1 with c-Cbl.
Tvorogov D, Carpenter G
Exp Cell Res. 2002
PubMed ID: 12061819
Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.
Loreto MP, Berry DM, McGlade CJ
Mol Cell Biol. 2002
PubMed ID: 12024036
APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes.
Liu J, Kimura A, Baumann CA, Saltiel AR
Mol Cell Biol. 2002
PubMed ID: 11997497
A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling.
Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M
J Biol Chem. 2002
PubMed ID: 11891219
Isolation and characterization of a novel, transforming allele of the c-Cbl proto-oncogene from a murine macrophage cell line.
Bisson SA, Ujack EE, Robbins SM
Oncogene. 2002
PubMed ID: 12032836
FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.
Wong A, Lamothe B, Lee A, Schlessinger J, Lax I, Li A
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11997436
Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement.
Saci A, Liu WQ, Vidal M, Garbay C, Rendu F, Bachelot-Loza C
Biochem J. 2002
PubMed ID: 11964172
The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins.
Egan JE, Hall AB, Yatsula BA, Bar-Sagi D
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11983899
c-Cbl associates directly with the C-terminal tail of the receptor for the macrophage colony-stimulating factor, c-Fms, and down-modulates this receptor but not the viral oncogene v-Fms.
Mancini A, Koch A, Wilms R, Tamura T
J Biol Chem. 2002
PubMed ID: 11847211
Negative regulation of Lck by Cbl ubiquitin ligase.
Rao N, Miyake S, Reddi AL, Douillard P, Ghosh AK, Dodge IL, Zhou P, Fernandes ND, Band H
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11904433
The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.
Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S
Nature. 2002
PubMed ID: 11894096
Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.
Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I
Nature. 2002
PubMed ID: 11894095
c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1.
Jehn BM, Dittert I, Beyer S, von der Mark K, Bielke W
J Biol Chem. 2002
PubMed ID: 11777909
Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation.
Howlett CJ, Robbins SM
Oncogene. 2002
PubMed ID: 11896602
The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl.
Hawash IY, Kesavan KP, Magee AI, Geahlen RL, Harrison ML
J Biol Chem. 2002
PubMed ID: 11741956
The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1.
Freywald A, Sharfe N, Roifman CM
J Biol Chem. 2002
PubMed ID: 11713248
C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus.
Wilhelmsen K, Burkhalter S, van der Geer P
Oncogene. 2002
PubMed ID: 11850825
A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.
Waterman H, Katz M, Rubin C, Shtiegman K, Lavi S, Elson A, Jovin T, Yarden Y
EMBO J. 2002
PubMed ID: 11823423
Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway.
Steen H, Kuster B, Fernandez M, Pandey A, Mann M
J Biol Chem. 2002
PubMed ID: 11687594
Regulation of immune responses by E3 ubiquitin-protein ligases.
Fang N, Fang D, Wang HY, Altman A, Liu YC
Curr Dir Autoimmun. 2002
PubMed ID: 11826757
The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.
Rao N, Ghosh AK, Ota S, Zhou P, Reddi AL, Hakezi K, Druker BK, Wu J, Band H
EMBO J. 2001
PubMed ID: 11742985
Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling.
Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J
J Exp Med. 2001
PubMed ID: 11696592
CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling.
Arai A, Kanda E, Nosaka Y, Miyasaka N, Miura O
J Biol Chem. 2001
PubMed ID: 11443118
A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.
Arron JR, Vologodskaia M, Wong BR, Naramura M, Kim N, Gu H, Choi Y
J Biol Chem. 2001
PubMed ID: 11406619
Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70.
Wang HY, Altman Y, Fang D, Elly C, Dai Y, Shao Y, Liu YC
J Biol Chem. 2001
PubMed ID: 11353765
Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor.
Miyoshi-Akiyama T, Aleman LM, Smith JM, Adler CE, Mayer BJ
Oncogene. 2001
PubMed ID: 11494134
Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7.
Ardley HC, Tan NG, Rose SA, Markham AF, Robinson PA
J Biol Chem. 2001
PubMed ID: 11278816
Requirement of tyrosine-phosphorylated Vav for morphological differentiation of all-trans-retinoic acid-treated HL-60 cells.
Bertagnolo V, Marchisio M, Brugnoli F, Bavelloni A, Boccafogli L, Colamussi ML, Capitani S
Cell Growth Differ. 2001
PubMed ID: 11331248
c-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPases.
Teckchandani AM, Feshchenko EA, Tsygankov AY
Oncogene. 2001
PubMed ID: 11313921
L-selectin tyrosine phosphorylates cbl and induces association of tyrosine-phosphorylated cbl with crkl and grb2.
Brenner B, Kadel S, Birle A, Linderkamp O
Biochem Biophys Res Commun. 2001
PubMed ID: 11263968
Evidence for direct interaction between Sprouty and Cbl.
Wong ES, Lim J, Low BC, Chen Q, Guy GR
J Biol Chem. 2001
PubMed ID: 11053437
Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.
Fang D, Wang HY, Fang N, Altman Y, Elly C, Liu YC
J Biol Chem. 2001
PubMed ID: 11087752
The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction.
Kirsch KH, Georgescu MM, Shishido T, Langdon WY, Birge RB, Hanafusa H
J Biol Chem. 2001
PubMed ID: 11067845
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation.
Thien CB, Walker F, Langdon WY
Mol Cell. 2001
PubMed ID: 11239464
SHP2 and cbl participate in alpha-chemokine receptor CXCR4-mediated signaling pathways.
Chernock RD, Cherla RP, Ganju RK
Blood. 2001
PubMed ID: 11157475
Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility.
Sanjay A, Houghton A, Neff L, DiDomenico E, Bardelay C, Antoine E, Levy J, Gailit J, Bowtell D, Horne WC, Baron R
J Cell Biol. 2001
PubMed ID: 11149930
Regulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cells.
Pedraza-Alva G, Sawasdikosol S, Liu YC, Mérida LB, Cruz-Muñoz ME, Oceguera-Yañez F, Burakoff SJ, Rosenstein Y
J Biol Chem. 2001
PubMed ID: 11024037
The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation.
Lin H, Martelli MP, Bierer BE
Int Immunol. 2001
PubMed ID: 11133830
SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins.
Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J, Bogler O
Cell Signal. 2000
PubMed ID: 11152963
Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes.
Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S
Biochem Biophys Res Commun. 2000
PubMed ID: 11071869
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Biochemistry. Ubiquitination--more than two to tango.
Joazeiro CA, Hunter T
Science. 2000
PubMed ID: 11032556
CAP defines a second signalling pathway required for insulin-stimulated glucose transport.
Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR
Nature. 2000
PubMed ID: 11001060
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
Zheng N, Wang P, Jeffrey PD, Pavletich NP
Cell. 2000
PubMed ID: 10966114
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells.
Alsayed Y, Modi S, Uddin S, Mahmud N, Druker BJ, Fish EN, Hoffman R, Platanias LC
Exp Hematol. 2000
PubMed ID: 10907644
Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase.
Scholz G, Cartledge K, Dunn AR
J Biol Chem. 2000
PubMed ID: 10799548
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
Cbl-b regulates the CD28 dependence of T-cell activation.
Chiang YJ, Kole HK, Brown K, Naramura M, Fukuhara S, Hu RJ, Jang IK, Gutkind JS, Shevach E, Gu H
Nature. 2000
PubMed ID: 10646609
The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration.
Uemura N, Griffin JD
J Biol Chem. 1999
PubMed ID: 10608804
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.
Levkowitz G, Waterman H, Ettenberg SA, Katz M, Tsygankov AY, Alroy I, Lavi S, Iwai K, Reiss Y, Ciechanover A, Lipkowitz S, Yarden Y
Mol Cell. 1999
PubMed ID: 10635327
High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase.
Park RK, Erdreich-Epstein A, Liu M, Izadi KD, Durden DL
J Immunol. 1999
PubMed ID: 10570290
The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module.
Rosenthal JA, Chen H, Slepnev VI, Pellegrini L, Salcini AE, Di Fiore PP, De Camilli P
J Biol Chem. 1999
PubMed ID: 10567358
Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7.
Yokouchi M, Kondo T, Houghton A, Bartkiewicz M, Horne WC, Zhang H, Yoshimura A, Baron R
J Biol Chem. 1999
PubMed ID: 10531381
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC
Science. 1999
PubMed ID: 10514377
Role of Syk in Fc gamma receptor-coupled tyrosine phosphorylation of Cbl in a manner susceptible to inhibition by protein kinase C.
Hazeki K, Hazeki O, Matsuo T, Seya T, Yamashita T, Nagasawa S, Band H, Ui M
Eur J Immunol. 1999
PubMed ID: 10540342
Role of Src in the modulation of multiple adaptor proteins in FcalphaRI oxidant signaling.
Park RK, Izadi KD, Deo YM, Durden DL
Blood. 1999
PubMed ID: 10477741
Identification and genetic mapping of differentially expressed genes in mice differing at the If1 interferon regulatory locus.
Kozak CA, Su Y, Raj NB, Pitha PM
Mamm Genome. 1999
PubMed ID: 10441734
SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling.
Tang J, Sawasdikosol S, Chang JH, Burakoff SJ
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10449770
The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor.
Waterman H, Levkowitz G, Alroy I, Yarden Y
J Biol Chem. 1999
PubMed ID: 10428778
The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro.
Morrogh LM, Hinshelwood S, Costello P, Cory GO, Kinnon C
Eur J Immunol. 1999
PubMed ID: 10427990
The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation.
Lee PS, Wang Y, Dominguez MG, Yeung YG, Murphy MA, Bowtell DD, Stanley ER
EMBO J. 1999
PubMed ID: 10393178
Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes.
Thien CB, Bowtell DD, Langdon WY
J Immunol. 1999
PubMed ID: 10358158
Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain.
Miyake S, Mullane-Robinson KP, Lill NL, Douillard P, Band H
J Biol Chem. 1999
PubMed ID: 10347229
APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl.
Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A
Leukemia. 1999
PubMed ID: 10374881
Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains.
Kim MG, Chen C, Lyu MS, Cho EG, Park D, Kozak C, Schwartz RH
Immunogenetics. 1999
PubMed ID: 10199918
The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.
Howlett CJ, Bisson SA, Resek ME, Tigley AW, Robbins SM
Biochem Biophys Res Commun. 1999
PubMed ID: 10092522
Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages.
Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL
J Leukoc Biol. 1999
PubMed ID: 10204582
Characterization and expression of the mouse Hsc70 gene.
Hunt CR, Parsian AJ, Goswami PC, Kozak CA
Biochim Biophys Acta. 1999
PubMed ID: 10095055
Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp.
Cohen S, Dadi H, Shaoul E, Sharfe N, Roifman CM
Blood. 1999
PubMed ID: 10068674
cbl-b inhibits epidermal growth factor receptor signaling.
Ettenberg SA, Keane MM, Nau MM, Frankel M, Wang LM, Pierce JH, Lipkowitz S
Oncogene. 1999
PubMed ID: 10086340
Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Meng W, Sawasdikosol S, Burakoff SJ, Eck MJ
Nature. 1999
PubMed ID: 10078535
A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells.
Zhang Z, Elly C, Qiu L, Altman A, Liu YC
Curr Biol. 1999
PubMed ID: 10074432
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.
Hunter S, Burton EA, Wu SC, Anderson SM
J Biol Chem. 1999
PubMed ID: 9890970
APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis.
Yokouchi M, Wakioka T, Sakamoto H, Yasukawa H, Ohtsuka S, Sasaki A, Ohtsubo M, Valius M, Inoue A, Komiya S, Yoshimura A
Oncogene. 1999
PubMed ID: 9989826
p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells.
Zhang S, Broxmeyer HE
Biochem Biophys Res Commun. 1999
PubMed ID: 9918857
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323.
Lupher ML, Rao N, Lill NL, Andoniou CE, Miyake S, Clark EA, Druker B, Band H
J Biol Chem. 1998
PubMed ID: 9857068
Altered thymic positive selection and intracellular signals in Cbl-deficient mice.
Naramura M, Kole HK, Hu RJ, Gu H
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9861006
Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc.
Liu SK, McGlade CJ
Oncogene. 1998
PubMed ID: 9872323
Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI).
Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp N, Groffen J, Durden DL
J Immunol. 1998
PubMed ID: 9820532
Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation.
Deckert M, Tartare-Deckert S, Hernandez J, Rottapel R, Altman A
Immunity. 1998
PubMed ID: 9846481
Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules.
Ito N, Wernstedt C, Engström U, Claesson-Welsh L
J Biol Chem. 1998
PubMed ID: 9722576
SLP-76-Cbl-Grb2-Shc interactions in FcgammaRI signaling.
Chu J, Liu Y, Koretzky GA, Durden DL
Blood. 1998
PubMed ID: 9716598
Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cbl.
Graham LJ, Stoica BA, Shapiro M, DeBell KE, Rellahan B, Laborda J, Bonvini E
Biochem Biophys Res Commun. 1998
PubMed ID: 9712732
Mouse nicotinamide N-methyltransferase gene: molecular cloning, structural characterization, and chromosomal localization.
Yan L, Otterness DM, Kozak CA, Weinshilboum RM
DNA Cell Biol. 1998
PubMed ID: 9726248
Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice.
Murphy MA, Schnall RG, Venter DJ, Barnett L, Bertoncello I, Thien CB, Langdon WY, Bowtell DD
Mol Cell Biol. 1998
PubMed ID: 9671496
The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha.
Miyake S, Lupher ML, Druker B, Band H
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9653117
CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling.
Park RK, Kyono WT, Liu Y, Durden DL
J Immunol. 1998
PubMed ID: 9590251
Thymocyte activation induces the association of the proto-oncoprotein c-cbl and ras GTPase-activating protein with CD5.
Dennehy KM, Broszeit R, Ferris WF, Beyers AD
Eur J Immunol. 1998
PubMed ID: 9603468
Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases.
Deckert M, Elly C, Altman A, Liu YC
J Biol Chem. 1998
PubMed ID: 9535867
The c-Cbl oncoprotein.
Lupher ML, Andoniou CE, Bonita D, Miyake S, Band H
Int J Biochem Cell Biol. 1998
PubMed ID: 9675877
Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells.
Gesbert F, Garbay C, Bertoglio J
J Biol Chem. 1998
PubMed ID: 9461587
A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes.
Ribon V, Printen JA, Hoffman NG, Kay BK, Saltiel AR
Mol Cell Biol. 1998
PubMed ID: 9447983
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE
Cell. 1998
PubMed ID: 9489702
The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.
Lupher ML, Songyang Z, Shoelson SE, Cantley LC, Band H
J Biol Chem. 1997
PubMed ID: 9407100
A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components.
Robertson H, Langdon WY, Thien CB, Bowtell DD
Biochem Biophys Res Commun. 1997
PubMed ID: 9367879
Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells.
Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O
Biochem Biophys Res Commun. 1997
PubMed ID: 9344843
Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity.
Bonita DP, Miyake S, Lupher ML, Langdon WY, Band H
Mol Cell Biol. 1997
PubMed ID: 9234717
Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation.
Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A
Oncogene. 1997
PubMed ID: 9233773
Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells.
Marengère LE, Mirtsos C, Kozieradzki I, Veillette A, Mak TW, Penninger JM
J Immunol. 1997
PubMed ID: 9200440
The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.
Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H
Oncogene. 1997
PubMed ID: 9223670
D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites.
Hime GR, Dhungat MP, Ng A, Bowtell DD
Oncogene. 1997
PubMed ID: 9178769
Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1).
Sattler M, Salgia R, Shrikhande G, Verma S, Uemura N, Law SF, Golemis EA, Griffin JD
J Biol Chem. 1997
PubMed ID: 9162067
CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2.
Husson H, Mograbi B, Schmid-Antomarchi H, Fischer S, Rossi B
Oncogene. 1997
PubMed ID: 9178909
Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase.
Jain SK, Langdon WY, Varticovski L
Oncogene. 1997
PubMed ID: 9174058
The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase.
Ota Y, Samelson LE
Science. 1997
PubMed ID: 9103201
Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl.
Odai H, Sasaki K, Iwamatsu A, Nakamoto T, Ueno H, Yamagata T, Mitani K, Yazaki Y, Hirai H
Blood. 1997
PubMed ID: 9108392
Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL).
Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD
J Biol Chem. 1997
PubMed ID: 9092574
Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling.
Fusaki N, Iwamatsu A, Iwashima M, Fujisawa J
J Biol Chem. 1997
PubMed ID: 9045636
The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway.
Ojaniemi M, Martin SS, Dolfi F, Olefsky JM, Vuori K
J Biol Chem. 1997
PubMed ID: 9013636
Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development.
Wang DZ, Hammond VE, Abud HE, Bertoncello I, McAvoy JW, Bowtell DD
Genes Dev. 1997
PubMed ID: 9030684
SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells.
Hendricks-Taylor LR, Motto DG, Zhang J, Siraganian RP, Koretzky GA
J Biol Chem. 1997
PubMed ID: 8995445
The Cbl family of signal transduction molecules.
Smit L, Borst J
Crit Rev Oncog. 1997
PubMed ID: 9622055
Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation.
Heaney C, Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, Druker BJ
Blood. 1997
PubMed ID: 8978305
Discrete protein interactions with the Grb2/c-Cbl complex in SCF- and TPO-mediated myeloid cell proliferation.
Brizzi MF, Dentelli P, Lanfrancone L, Rosso A, Pelicci PG, Pegoraro L
Oncogene. 1996
PubMed ID: 8950973
Identification of Itk/Tsk Src homology 3 domain ligands.
Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ
J Biol Chem. 1996
PubMed ID: 8810341
c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.
Tanaka S, Amling M, Neff L, Peyman A, Uhlmann E, Levy JB, Baron R
Nature. 1996
PubMed ID: 8849724
A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells.
Lupher ML, Reedquist KA, Miyake S, Langdon WY, Band H
J Biol Chem. 1996
PubMed ID: 8798643
Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases.
Latour S, Chow LM, Veillette A
J Biol Chem. 1996
PubMed ID: 8798454
Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism.
Hartley D, Corvera S
J Biol Chem. 1996
PubMed ID: 8702998
Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase.
Uddin S, Gardziola C, Dangat A, Yi T, Platanias LC
Biochem Biophys Res Commun. 1996
PubMed ID: 8780698
p120c-cbl is present in human blood platelets and is differentially involved in signaling by thrombopoietin and thrombin.
Oda A, Ozaki K, Druker BJ, Miyakawa Y, Miyazaki H, Handa M, Morita H, Ohashi H, Ikeda Y
Blood. 1996
PubMed ID: 8695851
Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene.
Pecker I, Avraham KB, Gilbert DJ, Savitsky K, Rotman G, Harnik R, Fukao T, Schröck E, Hirotsune S, Tagle DA, Collins FS, Wynshaw-Boris A, Ried T, Copeland NG, Jenkins NA, Shiloh Y, Ziv Y
Genomics. 1996
PubMed ID: 8661102
Activation-modulated association of 14-3-3 proteins with Cbl in T cells.
Liu YC, Elly C, Yoshida H, Bonnefoy-Berard N, Altman A
J Biol Chem. 1996
PubMed ID: 8663231
Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins.
Fukazawa T, Miyake S, Band V, Band H
J Biol Chem. 1996
PubMed ID: 8662998
Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors.
Smit L, van der Horst G, Borst J
J Biol Chem. 1996
PubMed ID: 8621483
p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase.
Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H
J Biol Chem. 1996
PubMed ID: 8621719
Molecular cloning of a highly conserved mouse and human integral membrane protein (Itm1) and genetic mapping to mouse chromosome 9.
Hong G, Deleersnijder W, Kozak CA, Van Marck E, Tylzanowski P, Merregaert J
Genomics. 1996
PubMed ID: 8838310
p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl.
Salgia R, Sattler M, Pisick E, Li JL, Griffin JD
Exp Hematol. 1996
PubMed ID: 8641358
The chromosomal distribution of mouse odorant receptor genes.
Sullivan SL, Adamson MC, Ressler KJ, Kozak CA, Buck LB
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8570653
Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.
Fournel M, Davidson D, Weil R, Veillette A
J Exp Med. 1996
PubMed ID: 8551236
The cbl oncogene: a novel substrate of protein tyrosine kinases.
Langdon WY
Aust N Z J Med. 1995
PubMed ID: 8770364
c-Cbl is inducibly tyrosine-phosphorylated by epidermal growth factor stimulation in fibroblasts, and constitutively tyrosine-phosphorylated and associated with v-Src in v-src-transformed fibroblasts.
Odai H, Sasaki K, Hanazono Y, Ueno H, Tanaka T, Miyagawa K, Mitani K, Yazaki Y, Hirai H
Jpn J Cancer Res. 1995
PubMed ID: 8635998
Cloning of the murine homolog of the leukemia-associated PML gene.
Goddard AD, Yuan JQ, Fairbairn L, Dexter M, Borrow J, Kozak C, Solomon E
Mamm Genome. 1995
PubMed ID: 8563172
Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation.
Galisteo ML, Dikic I, Batzer AG, Langdon WY, Schlessinger J
J Biol Chem. 1995
PubMed ID: 7657591
The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase.
Fukazawa T, Reedquist KA, Trub T, Soltoff S, Panchamoorthy G, Druker B, Cantley L, Shoelson SE, Band H
J Biol Chem. 1995
PubMed ID: 7642581
Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl.
Hartley D, Meisner H, Corvera S
J Biol Chem. 1995
PubMed ID: 7629144
The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase.
Cory GO, Lovering RC, Hinshelwood S, MacCarthy-Morrogh L, Levinsky RJ, Kinnon C
J Exp Med. 1995
PubMed ID: 7629518
Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2.
Jones C, Penny L, Mattina T, Yu S, Baker E, Voullaire L, Langdon WY, Sutherland GR, Richards RI, Tunnacliffe A
Nature. 1995
PubMed ID: 7603564
Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways.
Tanaka S, Neff L, Baron R, Levy JB
J Biol Chem. 1995
PubMed ID: 7782294
Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors.
Marcilla A, Rivero-Lezcano OM, Agarwal A, Robbins KC
J Biol Chem. 1995
PubMed ID: 7721825
Physical linkage of the fragile site FRA11B and a Jacobsen syndrome chromosome deletion breakpoint in 11q23.3.
Jones C, Slijepcevic P, Marsh S, Baker E, Langdon WY, Richards RI, Tunnacliffe A
Hum Mol Genet. 1994
PubMed ID: 7881408
The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.
Donovan JA, Wange RL, Langdon WY, Samelson LE
J Biol Chem. 1994
PubMed ID: 8083187
In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase.
Motto DG, Ross SE, Jackman JK, Sun Q, Olson AL, Findell PR, Koretzky GA
J Biol Chem. 1994
PubMed ID: 8063801
Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene.
Rivero-Lezcano OM, Sameshima JH, Marcilla A, Robbins KC
J Biol Chem. 1994
PubMed ID: 7517397
A rearrangement of the c-cbl proto-oncogene in HUT78 T-lymphoma cells results in a truncated protein.
Blake TJ, Langdon WY
Oncogene. 1992
PubMed ID: 1565471
The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.
Blake TJ, Shapiro M, Morse HC, Langdon WY
Oncogene. 1991
PubMed ID: 2030914
Assignment of the gene for intercellular adhesion molecule-1 (Icam-1) to proximal mouse chromosome 9.
Ballantyne CM, Kozak CA, O'Brien WE, Beaudet AL
Genomics. 1991
PubMed ID: 1674500
Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse.
Eng CM, Kozak CA, Beaudet AL, Zoghbi HY
Genomics. 1991
PubMed ID: 2004777
Relationship of the human protooncogene CBL2 on 11q23 to the t(4;11), t(11;22), and t(11;14) breakpoints.
Savage PD, Shapiro M, Langdon WY, Geurts van Kessel AD, Seuanez HN, Akao Y, Croce C, Morse HC, Kersey JH
Cytogenet Cell Genet. 1991
PubMed ID: 2013228
Identification of a common viral integration region in Cas-Br-E murine leukemia virus-induced non-T-, non-B-cell lymphomas.
Bergeron D, Poliquin L, Kozak CA, Rassart E
J Virol. 1991
PubMed ID: 1845910
Characterization of Int-5, a locus associated with early events in mammary carcinogenesis.
Morris VL, Rao TR, Kozak CA, Gray DA, Lee Chan EC, Cornell TJ, Taylor CB, Jones RF, McGrath CM
Oncogene Res. 1991
PubMed ID: 1705320
Identification of two murine loci homologous to the v-cbl oncogene.
Regnier DC, Kozak CA, Kingsley DM, Jenkins NA, Copeland NG, Langdon WY, Morse HC
J Virol. 1989
PubMed ID: 2760978
v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.
Langdon WY, Hartley JW, Klinken SP, Ruscetti SK, Morse HC
Proc Natl Acad Sci U S A. 1989
PubMed ID: 2784003
Classical conditioning of blood pressure in Macaca mulatta with cardiac rate controlled.
Turkkan JS, Schoenfeld WN
Pavlov J Biol Sci. 1979
PubMed ID: 119942
The behavior of holo- and apo-forms of bovine superoxide dismutase at low pH.
Fee JA, Phillips WD
Biochim Biophys Acta. 1975
PubMed ID: 82
[Stability of diluted solutions of peracetic acid]
Sláma V, Dudek J
Cesk Farm. 1968
PubMed ID: 5668240

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	867	12402	500985
EnsEMBL Gene(s)	ENSG00000110395	ENSMUSG00000034342	ENSRNOG00000008444
Unigene	Hs.504096	Mm.266871	Rn.35589
Homologene	CBL	Cbl	Cbl
OMIM	165360	N/A	N/A
GeneCards	CBL	N/A	N/A
Beta Cell Genomics	DT.453210	DT.101724794 DT.40164337 DT.55281861	N/A
Reactome	P22681	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	867	12402	500985

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
CBL	ABI1	MINT	empirical	17395426
CBL	FLOT1	BioGRID	empirical	11001060
CBL	SPRY1	MINT, Reactome	empirical	16893902 15962011 12593795 12234920
CBL	SPRY2	HPRD, MINT, BioGRID, Reactome	empirical	11053437 12234920 18273061 16893902 15962011 17974561 16246327 12593796 12593795 11983899 20029031 20124286 20461437 20877636 21596750 15004239 12815057
CBL	UBE4B	BioGRID	empirical	20696396
CBL	SORBS1	HPRD, BioGRID	empirical	11001060 15128873 12504111
CBL	SH2B2	HPRD, MINT, BioGRID	empirical	11997497 15031295 9233773 10374881 18273061 15737992
CBL	KHDRBS1	HPRD, IntAct	empirical	9045636
CBL	CFTR	BioGRID	empirical	20525683
CBL	FRS2	HPRD, BioGRID	empirical	11997436
CBL	YWHAQ	HPRD, BioGRID	empirical	11024037 8663231
CBL	CRK	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	8621483 8662998 15581361 19380743 20697350 9461587 9178909 8649859 8626543
CBL	CRKL	HPRD, MINT, BioGRID, Reactome	empirical	12244174 9590251 9162067 8621483 8978305 16982329 8662998 15556646 10907644 9820532 11133830 9092574 10204582 9461587 9344843 15107835 8649859 8626543
CBL	CSF1	BioGRID	empirical	17353186
CBL	CSF1R	HPRD, BioGRID	empirical	11847211 11850825
CBL	CSK	IntAct, BioGRID	empirical	19380743 11149930
CBL	EEF1A1	BioGRID	empirical	15107835
CBL	EGF	Reactome	predicted	15962011 11894095 16407834 15475003 15021893 10514377 7657591 15117950 10567358 15701692 12072436 12218189
CBL	EGFR	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	8662998 11994282 11239464 9890970 10092522 10799548 16729043 7657591 8798643 18273061 15962011 15677445 20562913 15657067 10086340 12061819 18316398 18508924 17995934 17971399 17545148 17486068 16969069 16246327 16105874 15668240 15282549 15159412 15107835 14505571 12734385 12604776 12593795 10428778 17242169 20029031 21772844 20124286 19225046 19531499 20877636 19713535 22203672 17372273 17139251 15210722 20940296 11894095 16407834 15475003 15021893 10514377 15117950 10567358 15701692 12072436 12218189
CBL	EPHA2	HPRD	empirical	12496371
CBL	EPHA8	BioGRID	empirical	20100865
CBL	EPHB1	BioGRID	empirical	18034775
CBL	EPHB6	HPRD	empirical	11713248
CBL	EPOR	HPRD	empirical	11443118
CBL	F2RL1	HPRD, MINT, IntAct, BioGRID	empirical	15708858
CBL	PTK2B	HPRD, BioGRID	empirical	11149930 15128873
CBL	FCGR1A	MINT	empirical	9716598
CBL	FCGR2A	BioGRID	empirical	19201892
CBL	FGR	HPRD, BioGRID	empirical	12435267 7721825
CBL	FNBP1	HPRD	empirical	18273061
CBL	FLT1	MINT, BioGRID	empirical	18273061 17962812
CBL	CD2AP	HPRD, MINT, BioGRID	empirical	11067845 12618476 17020880 12559036 15128873
CBL	ABL1	HPRD, MINT, BioGRID	empirical	12475393 15556646 11494134 20675402
CBL	FYB	HPRD	empirical	16503409
CBL	FYN	HPRD, MINT, BioGRID, Reactome	empirical	9535867 8621719 119942 82 11239464 9890970 10092522 10799548 7642581 15556646 17094785 19734451 7537740 9525940 18374639 8995358 9259313 9590251
CBL	GAPDH	BioGRID	empirical	15107835
CBL	GAPVD1	BioGRID	empirical	17545148
CBL	PTPN22	HPRD	empirical	10068674
CBL	OSTF1	HPRD	empirical	15135048
CBL	LAT	HPRD	empirical	8798643
CBL	GRB2	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	9295052 11964172 9108316 169092 11133830 917890 98621719 8621483 8995445 8063801 14725908 16906159 9234717 18273061 15677445 8621719 8662998 9716598 7642581 17094785 19380743 20936779 21706016 7657591 9174058 9872323 10086340 11997436 9367879 8083187 10570290 10204582 9461587 9178909 9108392 17971399 12839496 11823423 20124286 17372273 15210722 11894095 10567358 15117950 7537740 9525940 18374639 8995358 9259313 9590251
CBL	BLNK	Reactome	predicted	17202354
CBL	EPN1	Reactome	predicted	15962011 10567358 15701692 12072436 12218189
CBL	SH3KBP1	HPRD, MINT, BioGRID, Reactome	empirical	11894095 12618476 12177062 10679202 16407834 19268472 15090612 11071869 11894096 11152963 15456872 12135478 15107835 20130058
CBL	HCK	HPRD, BioGRID	empirical	10092522 11994282 11239464 9890970 10799548 11896602
CBL	HSPA4	BioGRID	empirical	21203488
CBL	HSPA5	BioGRID	empirical	21203488
CBL	IGF1R	HPRD, BioGRID	empirical	18632619
CBL	IL6ST	BioGRID	empirical	18519587
CBL	IL7R	BioGRID	empirical	20404156
CBL	INPPL1	HPRD, IntAct, BioGRID	empirical	12504111 19380743 15668240 19880507
CBL	INSR	HPRD	empirical	11997497 10635327
CBL	IRS1	BioGRID	empirical	19546233
CBL	ITGA5	BioGRID	empirical	15728256
CBL	ITK	HPRD, BioGRID	empirical	8810341
CBL	KDR	HPRD, BioGRID	empirical	12649282 17372230
CBL	KIT	HPRD, BioGRID	empirical	8950973 15315962
CBL	KRT18	HPRD, BioGRID	empirical	9367879
CBL	LCK	HPRD, MINT, BioGRID	empirical	9178909 11904433 11741956 16107303 7721825 8621719
CBL	LCP2	HPRD, MINT, BioGRID	empirical	10204582 9716598 10477741
CBL	LTK	HPRD, BioGRID	empirical	9223670
CBL	LYN	HPRD, MINT, BioGRID	empirical	12149655 8621719 12244174
CBL	STS	MINT	empirical	15159412
CBL	MET	HPRD, MINT, BioGRID	empirical	11894096 18273061 16397241 15123609 19450681
CBL	MST1R	MINT, BioGRID	empirical	18273061 16740632 12802274
CBL	MYH9	BioGRID	empirical	21203488
CBL	NCK1	HPRD, MINT, BioGRID	empirical	7517397 10204582 11494134
CBL	NEDD4	BioGRID	empirical	18931680
CBL	NGFR	BioGRID	empirical	15337528
CBL	NOTCH1	HPRD, BioGRID	empirical	11777909
CBL	NTRK1	BioGRID	empirical	21570973
CBL	ASAP1	HPRD, MINT	empirical	17255943
CBL	PDGFRA	HPRD, BioGRID	empirical	9234717
CBL	PDGFRB	HPRD, BioGRID	empirical	10514377 10347229 17620338
CBL	PIK3CA	IntAct, BioGRID	empirical	19380743 8641358
CBL	PIK3CB	IntAct	empirical	19380743
CBL	PIK3R1	HPRD, MINT, IntAct, BioGRID	empirical	11133830 8621719 8662998 16219545 7642581 9234717 15581361 16982329 9890970 15556646 19380743 9174058 9461587 9918857 18374639 15107835 11994282 11087752 21203488
CBL	PIK3R2	HPRD, IntAct, BioGRID	empirical	7629144 19380743 11133830 15107835
CBL	PLCG1	HPRD, BioGRID	empirical	12061819 9712732 16467851 9234717 17372230
CBL	STAP2	BioGRID	empirical	19401194
CBL	PRKCA	HPRD	empirical	11024037
CBL	AXL	HPRD, BioGRID	empirical	15958209
CBL	MAPK8	MINT	empirical	16982329
CBL	PSMC5	BioGRID	empirical	20479273
CBL	BAG1	BioGRID	empirical	20675402
CBL	PTK2	BioGRID	empirical	22203672
CBL	PTPN6	HPRD, BioGRID	empirical	12176909
CBL	PTPN11	HPRD, BioGRID	empirical	11157475 18519587
CBL	PTPRB	IntAct	empirical	19167335
CBL	PTPRC	IntAct	empirical	19167335
CBL	PTPRG	IntAct	empirical	19167335
CBL	PTPRJ	IntAct	empirical	19167335
CBL	PTPRK	IntAct	empirical	19167335
CBL	ACTA1	BioGRID	empirical	21203488
CBL	PTPRO	IntAct	empirical	19167335
CBL	PXN	BioGRID	empirical	8641358 22203672
CBL	EPS15L1	Reactome	predicted	15962011 10567358 15701692 12072436 12218189
CBL	RET	HPRD, MINT, BioGRID	empirical	12727845 15677445 16525057
CBL	ACTB	BioGRID	empirical	21203488
CBL	BCR	BioGRID	empirical	8641358 20675402
CBL	SCN5A	HPRD	empirical	8621719
CBL	BLK	HPRD, MINT	empirical	8083187 8621719
CBL	SH3BP2	BioGRID	empirical	9846481
CBL	ITSN1	MINT, IntAct, BioGRID	empirical	16914641 18654987 22158968
CBL	SH3GL2	MINT, BioGRID	empirical	11894095
CBL	SH3GL3	BioGRID	empirical	11894096
CBL	SHC1	HPRD, MINT, IntAct, BioGRID	empirical	10570290 8621719 8662998 9234717 15677445 19380743 7657591 9461587
CBL	SLA	HPRD, BioGRID	empirical	10449770 16327786
CBL	SPTA1	IntAct	empirical	19380743
CBL	SRC	HPRD, MINT, BioGRID	empirical	8635998 17141222 18273061 17094785 16636290 11994282 22203672
CBL	TRIM21	IntAct	empirical	19380743
CBL	STAT5A	HPRD	empirical	12193575
CBL	STAT5B	HPRD	empirical	12193575
CBL	SYK	HPRD, MINT, MIPS, BioGRID	empirical	8621719 11133830 9857068 10540342 18273061 7721825 15556646 10570266 11331248 12435267 15577829 11742985 19419964
CBL	BTK	HPRD, BioGRID	empirical	10427990 7629518
CBL	TEK	BioGRID	empirical	19689429
CBL	TLN1	BioGRID	empirical	8641358
CBL	TRAF6	HPRD	empirical	11406619
CBL	TYK2	HPRD, BioGRID	empirical	8780698
CBL	UBA52	Reactome	predicted	15004239 12593796 12593795 15021893 10514377
CBL	UBB	Reactome	predicted	15004239 12593796 12593795 15021893 10514377
CBL	UBC	BioGRID, Reactome	empirical	18508924 17679095 15456872 15107835 11896602 20029031 19341794 22203672 15273720 15004239 12593796 12593795 15021893 10514377
CBL	UBA1	BioGRID	empirical	18508924
CBL	UBE2D1	BioGRID	empirical	18508924
CBL	UBE2D2	HPRD, BioGRID	empirical	10514377
CBL	UBE2G1	HPRD	empirical	11032556
CBL	UBE2G2	HPRD	empirical	11032556
CBL	UBE2L3	HPRD, MINT, BioGRID	empirical	10966114 10531381 11278816 12234920 16735510
CBL	VAV1	HPRD, BioGRID, Reactome	empirical	9200440 11133830 11331248 12881521 16356860
CBL	VAV2	HPRD, BioGRID	empirical	11313921 20940296
CBL	VIM	BioGRID	empirical	21203488
CBL	YWHAB	HPRD, BioGRID	empirical	9367879
CBL	YWHAE	BioGRID	empirical	16944949
CBL	YWHAG	HPRD	empirical	15324660
CBL	YWHAZ	HPRD, BioGRID	empirical	9367879
CBL	ZAP70	HPRD, BioGRID	empirical	11133830 10074432 8798643 10078535 11353765
CBL	SPRY4	MINT, BioGRID	empirical	18273061
CBL	CAPN1	HPRD	empirical	8695851
CBL	ITCH	HPRD, MINT, BioGRID	empirical	12226085 19341794
CBL	SLA2	HPRD	empirical	12024036 11891219
CBL	SORBS2	HPRD, BioGRID	empirical	12475393 15128873
CBL	UBASH3B	HPRD, BioGRID	empirical	15159412
CBL	CBL	HPRD, BioGRID	empirical	8995445 8063801 10078535 15677445 17679095 17635922
CBL	TNFRSF11A	HPRD	empirical	11406619
CBL	TNFRSF10B	BioGRID	empirical	19932172
CBL	TNFRSF10A	BioGRID	empirical	19932172
CBL	ARHGEF7	MINT, Reactome	empirical	16407834
CBL	CDKL2	HPRD	empirical	7721825
CBL	UBE2M	BioGRID	empirical	16735510
CBL	CD247	BioGRID	empirical	11353765
CBL	CD5	HPRD, BioGRID	empirical	9603468
CBL	CD19	HPRD	empirical	9178909
CBL	GRAP2	BioGRID	empirical	9872323
CBL	CD33	BioGRID	empirical	18062779
CBL	CD40	HPRD	empirical	12637493
CBL	EIF5B	HPRD	empirical	8621719
CBL	CDC42	BioGRID	empirical	14505571 16356860