TP63

Summary Top Help

Gene Description:

transformation related protein 63; tumor protein p63

Synonyms:

Trp63, Ket, EEC3, TP63, TP53CP, P73l, p63, B(p51B), p73H, AI462811, p51, AIS, P51/P63, Trp53rp1, p40, TP73L, SHFM4, OFC8, P63, RHS, Tp63, KET, B(p51A), NBP, LMS, TP53L, p53CP, Tp73l, p73L

Orthologs:

Human TP63 (protein-coding), Mouse Trp63 (protein-coding), Rat Tp63 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Iddm17	Rat	chr11:19445919..87759784	68.31	594

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr3:189349205..189615068 (265.86 kb) View in Genome Browser

(Mouse) NCBIM37 - chr16:25683849..25892188 (208.34 kb) View in Genome Browser

(Rat) RGSC3.4 - chr11:76900622..77200251 (299.63 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for TP63:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for TP63:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: 2

Gene Ontology: 63

Negative regulation of transcription from RNA polymerase II promoter	GO:0000122
Chromatin	GO:0000785
Skeletal system development	GO:0001501
Establishment of planar polarity	GO:0001736
P53 binding	GO:0002039
Positive regulation of mesenchymal cell proliferation	GO:0002053
Epithelial cell development	GO:0002064
DNA binding	GO:0003677
Chromatin binding	GO:0003682
Damaged DNA binding	GO:0003684
Double-stranded DNA binding	GO:0003690
Sequence-specific DNA binding transcription factor activity	GO:0003700
Protein binding	GO:0005515
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Transcription factor complex	GO:0005667
Nucleolus	GO:0005730
Cytoplasm	GO:0005737
Golgi apparatus	GO:0005794
Cytosol	GO:0005829
Apoptotic process	GO:0006915
Anti-apoptosis	GO:0006916
Induction of apoptosis	GO:0006917
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978
Pattern specification process	GO:0007389
Ectoderm and mesoderm interaction	GO:0007499
Cell aging	GO:0007569
Organ morphogenesis	GO:0009887
Proximal/distal pattern formation	GO:0009954
Response to X-ray	GO:0010165
Multicellular organismal aging	GO:0010259
Response to gamma radiation	GO:0010332
Embryonic limb morphogenesis	GO:0030326
Dendrite	GO:0030425
Prostate gland development	GO:0030850
Polarized epithelial cell differentiation	GO:0030859
Hair follicle morphogenesis	GO:0031069
Mitotic cell cycle G1/S transition DNA damage checkpoint	GO:0031571
Cellular response to UV	GO:0034644
Tail morphogenesis	GO:0035121
Odontogenesis of dentin-containing tooth	GO:0042475
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	GO:0042771
Identical protein binding	GO:0042802
Regulation of neuron apoptosis	GO:0043523
Sequence-specific DNA binding	GO:0043565
Skin morphogenesis	GO:0043589
Keratinocyte proliferation	GO:0043616
Transcription regulatory region DNA binding	GO:0044212
Negative regulation of keratinocyte differentiation	GO:0045617
Positive regulation of Notch signaling pathway	GO:0045747
Negative regulation of transcription, DNA-dependent	GO:0045892
Positive regulation of transcription, DNA-dependent	GO:0045893
Positive regulation of transcription from RNA polymerase II promoter	GO:0045944
Metal ion binding	GO:0046872
Sympathetic nervous system development	GO:0048485
Anatomical structure formation involved in morphogenesis	GO:0048646
Smooth muscle tissue development	GO:0048745
Female genitalia morphogenesis	GO:0048807
Protein homotetramerization	GO:0051289
Urinary bladder development	GO:0060157
Cloacal septation	GO:0060197
Prostatic bud formation	GO:0060513
Squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	GO:0060529

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: 2

Direct p53 effectors

Validated transcriptional targets of deltaNp63 isoforms

Gene Ontology: 63
Negative regulation of transcription from RNA polymerase II promoter	GO:0000122
Chromatin	GO:0000785
Skeletal system development	GO:0001501
Establishment of planar polarity	GO:0001736
P53 binding	GO:0002039
Positive regulation of mesenchymal cell proliferation	GO:0002053
Epithelial cell development	GO:0002064
DNA binding	GO:0003677
Chromatin binding	GO:0003682
Damaged DNA binding	GO:0003684
Double-stranded DNA binding	GO:0003690
Sequence-specific DNA binding transcription factor activity	GO:0003700
Protein binding	GO:0005515
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Transcription factor complex	GO:0005667
Nucleolus	GO:0005730
Cytoplasm	GO:0005737
Golgi apparatus	GO:0005794
Cytosol	GO:0005829
Apoptotic process	GO:0006915
Anti-apoptosis	GO:0006916
Induction of apoptosis	GO:0006917
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978
Pattern specification process	GO:0007389
Ectoderm and mesoderm interaction	GO:0007499
Cell aging	GO:0007569
Organ morphogenesis	GO:0009887
Proximal/distal pattern formation	GO:0009954
Response to X-ray	GO:0010165
Multicellular organismal aging	GO:0010259
Response to gamma radiation	GO:0010332
Embryonic limb morphogenesis	GO:0030326
Dendrite	GO:0030425
Prostate gland development	GO:0030850
Polarized epithelial cell differentiation	GO:0030859
Hair follicle morphogenesis	GO:0031069
Mitotic cell cycle G1/S transition DNA damage checkpoint	GO:0031571
Cellular response to UV	GO:0034644
Tail morphogenesis	GO:0035121
Odontogenesis of dentin-containing tooth	GO:0042475
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	GO:0042771
Identical protein binding	GO:0042802
Regulation of neuron apoptosis	GO:0043523
Sequence-specific DNA binding	GO:0043565
Skin morphogenesis	GO:0043589
Keratinocyte proliferation	GO:0043616
Transcription regulatory region DNA binding	GO:0044212
Negative regulation of keratinocyte differentiation	GO:0045617
Positive regulation of Notch signaling pathway	GO:0045747
Negative regulation of transcription, DNA-dependent	GO:0045892
Positive regulation of transcription, DNA-dependent	GO:0045893
Positive regulation of transcription from RNA polymerase II promoter	GO:0045944
Metal ion binding	GO:0046872
Sympathetic nervous system development	GO:0048485
Anatomical structure formation involved in morphogenesis	GO:0048646
Smooth muscle tissue development	GO:0048745
Female genitalia morphogenesis	GO:0048807
Protein homotetramerization	GO:0051289
Urinary bladder development	GO:0060157
Cloacal septation	GO:0060197
Prostatic bud formation	GO:0060513
Squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	GO:0060529

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 609

DeltaN TP63 reactivation, epithelial phenotype maintenance, and survival in lung squamous cell carcinoma.
Pallier K, Cazes A, El Khattabi L, Lecchi C, Desroches M, Danel C, Riquet M, Fabre-Guillevin E, Laurent-Puig P, Blons H
Tumour Biol. 2012
PubMed ID: 21986963
Limbal stem cell deficiency and ocular phenotype in ectrodactyly-ectodermal dysplasia-clefting syndrome caused by p63 mutations.
Di Iorio E, Kaye SB, Ponzin D, Barbaro V, Ferrari S, Böhm E, Nardiello P, Castaldo G, McGrath JA, Willoughby CE
Ophthalmology. 2012
PubMed ID: 21959367
Tumor protein p63/nuclear factor κB feedback loop in regulation of cell death.
Sen T, Sen N, Huang Y, Sinha D, Luo ZG, Ratovitski EA, Sidransky D
J Biol Chem. 2011
PubMed ID: 22020940
p63 regulates olfactory stem cell self-renewal and differentiation.
Fletcher RB, Prasol MS, Estrada J, Baudhuin A, Vranizan K, Choi YG, Ngai J
Neuron. 2011
PubMed ID: 22153372
Additive effect of TAp63 deficiency on the adrenocortical dysplasia (acd) phenotype.
O'Connor BC, Macke EL, Keegan CE
Mamm Genome. 2011
PubMed ID: 22038471
14-3-3σ and p63 play opposing roles in epidermal tumorigenesis.
Li Q, Sambandam SA, Lu HJ, Thomson A, Kim SH, Lu H, Xin Y, Lu Q
Carcinogenesis. 2011
PubMed ID: 21926108
Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma.
Matsubara R, Kawano S, Kiyosue T, Goto Y, Hirano M, Jinno T, Toyoshima T, Kitamura R, Oobu K, Nakamura S
Int J Oncol. 2011
PubMed ID: 21833468
Special AT-rich binding protein-2 (SATB2) differentially affects disease-causing p63 mutant proteins.
Chung J, Grant RI, Kaplan DR, Irwin MS
J Biol Chem. 2011
PubMed ID: 21965674
TP63 P2 promoter functional analysis identifies β-catenin as a key regulator of ΔNp63 expression.
Ruptier C, De Gaspéris A, Ansieau S, Granjon A, Tanière P, Lafosse I, Shi H, Petitjean A, Taranchon-Clermont E, Tribollet V, Voeltzel T, Scoazec JY, Maguer-Satta V, Puisieux A, Hainaut P, Cavard C, Caron de Fromentel C
Oncogene. 2011
PubMed ID: 21643019
DeltaNp63α protein triggers epithelial-mesenchymal transition and confers stem cell properties in normal human keratinocytes.
Oh JE, Kim RH, Shin KH, Park NH, Kang MK
J Biol Chem. 2011
PubMed ID: 21880709
TNF-α promotes c-REL/ΔNp63α interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer.
Lu H, Yang X, Duggal P, Allen CT, Yan B, Cohen J, Nottingham L, Romano RA, Sinha S, King KE, Weinberg WC, Chen Z, Van Waes C
Cancer Res. 2011
PubMed ID: 21933882
Comparison of the expression levels of napsin A, thyroid transcription factor-1, and p63 in nonsmall cell lung cancer using cytocentrifuged bronchial brushings.
Aikawa E, Kawahara A, Hattori S, Yamaguchi T, Abe H, Taira T, Azuma K, Kage M
Cancer Cytopathol. 2011
PubMed ID: 21717589
iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia.
Chikh A, Matin RN, Senatore V, Hufbauer M, Lavery D, Raimondi C, Ostano P, Mello-Grand M, Ghimenti C, Bahta A, Khalaf S, Akgül B, Braun KM, Chiorino G, Philpott MP, Harwood CA, Bergamaschi D
EMBO J. 2011
PubMed ID: 21897369
A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis.
Ferretti E, Li B, Zewdu R, Wells V, Hebert JM, Karner C, Anderson MJ, Williams T, Dixon J, Dixon MJ, Depew MJ, Selleri L
Dev Cell. 2011
PubMed ID: 21982646
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice.
Arnold K, Sarkar A, Yram MA, Polo JM, Bronson R, Sengupta S, Seandel M, Geijsen N, Hochedlinger K
Cell Stem Cell. 2011
PubMed ID: 21982232
[Unexpected role for p63 during heart development: one phenotype can hide another one].
Rouleau M, Pucéat M, Aberdam D
Med Sci (Paris). 2011
PubMed ID: 22027432
A high-resolution molecular atlas of the fetal mouse lower urogenital tract.
Abler LL, Keil KP, Mehta V, Joshi PS, Schmitz CT, Vezina CM
Dev Dyn. 2011
PubMed ID: 21905163
Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium.
Bell SM, Zhang L, Mendell A, Xu Y, Haitchi HM, Lessard JL, Whitsett JA
Dev Biol. 2011
PubMed ID: 21803035
Quantitative expression study of four cytokeratins and p63 in squamous cell carcinoma of the tongue: suitability for sentinel node navigation surgery using one-step nucleic acid amplification.
Yamauchi K, Fujioka Y, Kogashiwa Y, Kohno N
J Clin Pathol. 2011
PubMed ID: 21705376
Cytoplasmic p63 immunohistochemistry is a useful marker for muscle differentiation: an immunohistochemical and immunoelectron microscopic study.
Martin SE, Temm CJ, Goheen MP, Ulbright TM, Hattab EM
Mod Pathol. 2011
PubMed ID: 21623385
p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis.
Fessing MY, Mardaryev AN, Gdula MR, Sharov AA, Sharova TY, Rapisarda V, Gordon KB, Smorodchenko AD, Poterlowicz K, Ferone G, Kohwi Y, Missero C, Kohwi-Shigematsu T, Botchkarev VA
J Cell Biol. 2011
PubMed ID: 21930775
Loss of ΔNp63α promotes mitotic exit in epithelial cells.
Hau PM, Yip YL, Huen MS, Tsao SW
FEBS Lett. 2011
PubMed ID: 21821031
The human papillomavirus E6 oncogene represses a cell adhesion pathway and disrupts focal adhesion through degradation of TAp63β upon transformation.
Khalifa YB, Teissier S, Tan MK, Phan QT, Daynac M, Wong WQ, Thierry F
PLoS Pathog. 2011
PubMed ID: 21980285
Differences in p63 expression in SCCHN tumours of different sub-sites within the oral cavity.
Boldrup L, Coates PJ, Laurell G, Nylander K
Oral Oncol. 2011
PubMed ID: 21802344
p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.
Melino G
Cell Death Differ. 2011
PubMed ID: 21760596
p63 is necessary for the activation of human papillomavirus late viral functions upon epithelial differentiation.
Mighty KK, Laimins LA
J Virol. 2011
PubMed ID: 21715473
CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression.
Krais AM, Hautefeuille AH, Cros MP, Krutovskikh V, Tournier JM, Birembaut P, Thépot A, Paliwal A, Herceg Z, Boffetta P, Brennan P, Hainaut PL
Carcinogenesis. 2011
PubMed ID: 21586512
Characterization of a novel umbilical cord lining cell with CD227 positivity and unique pattern of P63 expression and function.
Reza HM, Ng BY, Phan TT, Tan DT, Beuerman RW, Ang LP
Stem Cell Rev. 2011
PubMed ID: 21181306
Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism.
Wu X, Xu K, Zhang L, Deng Y, Lee P, Shapiro E, Monaco M, Makarenkova HP, Li J, Lepor H, Grishina I
Dev Biol. 2011
PubMed ID: 21624358
Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome.
Barrott JJ, Cash GM, Smith AP, Barrow JR, Murtaugh LC
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21768372
A dominant mutation etiologic for human tricho-dento-osseous syndrome impairs the ability of DLX3 to downregulate ΔNp63α.
Di Costanzo A, Festa L, Roscigno G, Vivo M, Pollice A, Morasso M, La Mantia G, Calabrò V
J Cell Physiol. 2011
PubMed ID: 21520071
The secret second life of an innocent chaperone: the story of CD74 and B cell/chronic lymphocytic leukemia cell survival.
Shachar I, Haran M
Leuk Lymphoma. 2011
PubMed ID: 21417823
Expression and regulation of the ΔN and TAp63 isoforms in salivary gland tumorigenesis clinical and experimental findings.
Mitani Y, Li J, Weber RS, Lippman SL, Flores ER, Caulin C, El-Naggar AK
Am J Pathol. 2011
PubMed ID: 21703418
p63 expression in adamantinoma.
Dickson BC, Gortzak Y, Bell RS, Ferguson PC, Howarth DJ, Wunder JS, Kandel RA
Virchows Arch. 2011
PubMed ID: 21674157
Differential altered stability and transcriptional activity of ΔNp63 mutants in distinct ectodermal dysplasias.
Browne G, Cipollone R, Lena AM, Serra V, Zhou H, van Bokhoven H, Dötsch V, Merico D, Mantovani R, Terrinoni A, Knight RA, Candi E, Melino G
J Cell Sci. 2011
PubMed ID: 21652629
The utility of ERG/P63 double immunohistochemical staining in the diagnosis of limited cancer in prostate needle biopsies.
Yaskiv O, Zhang X, Simmerman K, Daly T, He H, Falzarano S, Chen L, Magi-Galluzzi C, Zhou M
Am J Surg Pathol. 2011
PubMed ID: 21623182
Variation in TP63 is associated with lung adenocarcinoma in the UK population.
Wang Y, Broderick P, Matakidou A, Vijayakrishnan J, Eisen T, Houlston RS
Cancer Epidemiol Biomarkers Prev. 2011
PubMed ID: 21610222
Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma.
Ramsey MR, He L, Forster N, Ory B, Ellisen LW
Cancer Res. 2011
PubMed ID: 21527555
Regulation of female reproduction by p53 and its family members.
Feng Z, Zhang C, Kang HJ, Sun Y, Wang H, Naqvi A, Frank AK, Rosenwaks Z, Murphy ME, Levine AJ, Hu W
FASEB J. 2011
PubMed ID: 21402718
Residual embryonic cells as precursors of a Barrett's-like metaplasia.
Wang X, Ouyang H, Yamamoto Y, Kumar PA, Wei TS, Dagher R, Vincent M, Lu X, Bellizzi AM, Ho KY, Crum CP, Xian W, McKeon F
Cell. 2011
PubMed ID: 21703447
DeltaNp63 regulates stem cell dynamics in the mammalian olfactory epithelium.
Packard A, Schnittke N, Romano RA, Sinha S, Schwob JE
J Neurosci. 2011
PubMed ID: 21677159
Non-hominid TP63 lacks retroviral LTRs but contains a novel conserved upstream exon.
Beyer U, Dobbelstein M
Cell Cycle. 2011
PubMed ID: 21558811
Large scale RNAi screen reveals that the inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation.
Wu N, Castel D, Debily MA, Vigano MA, Alibert O, Mantovani R, Iljin K, Romeo PH, Gidrol X
J Biol Chem. 2011
PubMed ID: 21478550
p63 expression in giant cell-containing lesions of bone and soft tissue.
de la Roza G
Arch Pathol Lab Med. 2011
PubMed ID: 21631272
STAT3 regulates the proliferation and differentiation of rabbit limbal epithelial cells via a ΔNp63-dependent mechanism.
Hsueh YJ, Chen HC, Chu WK, Cheng CC, Kuo PC, Lin LY, Ma HK, Chen JK
Invest Ophthalmol Vis Sci. 2011
PubMed ID: 21447682
Foxn4 influences alveologenesis during lung development.
Li S, Xiang M
Dev Dyn. 2011
PubMed ID: 21438071
Effect of narrow-band ultraviolet B phototherapy on p63 and microRNA (miR-21 and miR-125b) expression in psoriatic epidermis.
Gu X, Nylander E, Coates PJ, Nylander K
Acta Derm Venereol. 2011
PubMed ID: 21373745
Frequent ALK rearrangement and TTF-1/p63 co-expression in lung adenocarcinoma with signet-ring cell component.
Yoshida A, Tsuta K, Watanabe S, Sekine I, Fukayama M, Tsuda H, Furuta K, Shibata T
Lung Cancer. 2011
PubMed ID: 21036415
ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation.
Yang X, Lu H, Yan B, Romano RA, Bian Y, Friedman J, Duggal P, Allen C, Chuang R, Ehsanian R, Si H, Sinha S, Van Waes C, Chen Z
Cancer Res. 2011
PubMed ID: 21576089
p63 maintains keratinocyte proliferative capacity through regulation of Skp2-p130 levels.
McDade SS, Patel D, McCance DJ
J Cell Sci. 2011
PubMed ID: 21511729
Toll-like receptor 3 (TLR3) induces apoptosis via death receptors and mitochondria by up-regulating the transactivating p63 isoform alpha (TAP63alpha).
Sun R, Zhang Y, Lv Q, Liu B, Jin M, Zhang W, He Q, Deng M, Liu X, Li G, Li Y, Zhou G, Xie P, Xie X, Hu J, Duan Z
J Biol Chem. 2011
PubMed ID: 21367858
Role of epidermal primary cilia in the homeostasis of skin and hair follicles.
Croyle MJ, Lehman JM, O'Connor AK, Wong SY, Malarkey EB, Iribarne D, Dowdle WE, Schoeb TR, Verney ZM, Athar M, Michaud EJ, Reiter JF, Yoder BK
Development. 2011
PubMed ID: 21429982
Alk5-mediated transforming growth factor β signaling acts upstream of fibroblast growth factor 10 to regulate the proliferation and maintenance of dental epithelial stem cells.
Zhao H, Li S, Han D, Kaartinen V, Chai Y
Mol Cell Biol. 2011
PubMed ID: 21402782
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis.
Shalom-Feuerstein R, Lena AM, Zhou H, De La Forest Divonne S, Van Bokhoven H, Candi E, Melino G, Aberdam D
Cell Death Differ. 2011
PubMed ID: 21127502
Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements.
Chen C, Gorlatova N, Kelman Z, Herzberg O
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21464285
DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation.
Qian Y, Jung YS, Chen X
J Biol Chem. 2011
PubMed ID: 21317427
IKK1 control of epidermal differentiation is modulated by notch signaling.
Xin Y, Lu Q, Li Q
Am J Pathol. 2011
PubMed ID: 21435444
The p53 family: guardians of maternal reproduction.
Levine AJ, Tomasini R, McKeon FD, Mak TW, Melino G
Nat Rev Mol Cell Biol. 2011
PubMed ID: 21427767
D2-40/p63 defined lymph vessel invasion has additional prognostic value in highly proliferating operable node negative breast cancer patients.
Gudlaugsson E, Skaland I, Undersrud E, Janssen EA, Søiland H, Baak JP
Mod Pathol. 2011
PubMed ID: 21317878
Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center.
Compagnucci C, Fish JL, Schwark M, Tarabykin V, Depew MJ
Genesis. 2011
PubMed ID: 21309073
Essential roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiation.
Murashima A, Miyagawa S, Ogino Y, Nishida-Fukuda H, Araki K, Matsumoto T, Kaneko T, Yoshinaga K, Yamamura K, Kurita T, Kato S, Moon AM, Yamada G
Endocrinology. 2011
PubMed ID: 21303954
SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63.
Bornstein C, Brosh R, Molchadsky A, Madar S, Kogan-Sakin I, Goldstein I, Chakravarti D, Flores ER, Goldfinger N, Sarig R, Rotter V
Mol Cell Biol. 2011
PubMed ID: 21300779
14-3-3σ controls corneal epithelium homeostasis and wound healing.
Lu Q, Xin Y, Ye F, Foulks G, Li Q
Invest Ophthalmol Vis Sci. 2011
PubMed ID: 21228373
Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to 20S proteasomal degradation of p63 resulting in thinning of epithelium and chemical-induced skin cancer.
Patrick BA, Gong X, Jaiswal AK
Oncogene. 2011
PubMed ID: 21042282
The DeltaNp63 proteins are key allies of BRCA1 in the prevention of basal-like breast cancer.
Buckley NE, Conlon SJ, Jirstrom K, Kay EW, Crawford NT, O'Grady A, Sheehan K, Mc Dade SS, Wang CW, McCance DJ, Johnston PG, Kennedy RD, Harkin DP, Mullan PB
Cancer Res. 2011
PubMed ID: 21363924
Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression.
Karni-Schmidt O, Castillo-Martin M, HuaiShen T, Gladoun N, Domingo-Domenech J, Sanchez-Carbayo M, Li Y, Lowe S, Prives C, Cordon-Cardo C
Am J Pathol. 2011
PubMed ID: 21356385
Ionizing radiation-induced TAp63α phosphorylation at C-terminal S/TQ motifs requires the N-terminal transactivation (TA) domain.
Kim DA, Lee BL, Suh EK
Cell Cycle. 2011
PubMed ID: 21325887
Morphometric analysis and p63 improve the identification of myoepithelial cells in breast lesion cytology.
Aikawa E, Kawahara A, Kondo K, Hattori S, Kage M
Diagn Cytopathol. 2011
PubMed ID: 21319317
Regulation of mouse stomach development and Barx1 expression by specific microRNAs.
Kim BM, Woo J, Kanellopoulou C, Shivdasani RA
Development. 2011
PubMed ID: 21307095
Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes.
Beyer U, Moll-Rocek J, Moll UM, Dobbelstein M
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21300884
p63 and p73 isoform expression in non-small cell lung cancer and corresponding morphological normal lung tissue.
Iacono ML, Monica V, Saviozzi S, Ceppi P, Bracco E, Papotti M, Scagliotti GV
J Thorac Oncol. 2011
PubMed ID: 21289519
Inmunohistochemical profile of solid cell nest of thyroid gland.
Ríos Moreno MJ, Galera-Ruiz H, De Miguel M, López MI, Illanes M, Galera-Davidson H
Endocr Pathol. 2011
PubMed ID: 21234707
Mutant p53 subverts p63 control over KLF4 expression in keratinocytes.
Cordani N, Pozzi S, Martynova E, Fanoni D, Borrelli S, Alotto D, Castagnoli C, Berti E, Viganò MA, Mantovani R
Oncogene. 2011
PubMed ID: 20972454
DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer.
Deutsch GB, Zielonka EM, Coutandin D, Weber TA, Schäfer B, Hannewald J, Luh LM, Durst FG, Ibrahim M, Hoffmann J, Niesen FH, Sentürk A, Kunkel H, Brutschy B, Schleiff E, Knapp S, Acker-Palmer A, Grez M, McKeon F, Dötsch V
Cell. 2011
PubMed ID: 21335238
While p73 is essential, p63 is completely dispensable for the development of the central nervous system.
Holembowski L, Schulz R, Talos F, Scheel A, Wolff S, Dobbelstein M, Moll U
Cell Cycle. 2011
PubMed ID: 21293190
ΔNp63α/IRF6 interplay activates NOS2 transcription and induces autophagy upon tobacco exposure.
Ratovitski EA
Arch Biochem Biophys. 2011
PubMed ID: 21129360
Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin.
Zhang H, Pasolli HA, Fuchs E
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21262812
ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis.
Keyes WM, Pecoraro M, Aranda V, Vernersson-Lindahl E, Li W, Vogel H, Guo X, Garcia EL, Michurina TV, Enikolopov G, Muthuswamy SK, Mills AA
Cell Stem Cell. 2011
PubMed ID: 21295273
Dynamic expression of the p53 family members p63 and p73 in the mouse and human telencephalon during development and in adulthood.
Hernández-Acosta NC, Cabrera-Socorro A, Morlans MP, Delgado FJ, Suárez-Solá ML, Sottocornola R, Lu X, González-Gómez M, Meyer G
Brain Res. 2011
PubMed ID: 21114965
The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers.
Yang C, Hayashida T, Forster N, Li C, Shen D, Maheswaran S, Chen L, Anderson KS, Ellisen LW, Sgroi D, Schmidt EV
Cancer Res. 2011
PubMed ID: 21127199
Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia.
Dai D, Zhu H, Wlodarczyk B, Zhang L, Li L, Li AG, Finnell RH, Roop DR, Chen J
J Invest Dermatol. 2011
PubMed ID: 20962855
DeltaNp63alpha-mediated induction of epidermal growth factor receptor promotes pancreatic cancer cell growth and chemoresistance.
Danilov AV, Neupane D, Nagaraja AS, Feofanova EV, Humphries LA, DiRenzo J, Korc M
PLoS One. 2011
PubMed ID: 22053213
Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation.
Woo J, Miletich I, Kim BM, Sharpe PT, Shivdasani RA
PLoS One. 2011
PubMed ID: 21799872
Dysregulated ΔNp63α inhibits expression of Ink4a/arf, blocks senescence, and promotes malignant conversion of keratinocytes.
Ha L, Ponnamperuma RM, Jay S, Ricci MS, Weinberg WC
PLoS One. 2011
PubMed ID: 21789189
Diagnostic utility of p63/P501S double sequential immunohistochemical staining in differentiating urothelial carcinoma from prostate carcinoma.
Srinivasan M, Parwani AV
Diagn Pathol. 2011
PubMed ID: 21777423
Reduced expression of ΔΝp63α in cervical squamous cell carcinoma.
Zhou Y, Xu Q, Ling B, Xiao W, Liu P
Clin Invest Med. 2011
PubMed ID: 21631996
D2-40: an additional marker for myoepithelial cells of breast and the precaution in interpreting tumor lymphovascular invasion.
Ren S, Abuel-Haija M, Khurana JS, Zhang X
Int J Clin Exp Pathol. 2011
PubMed ID: 21326813
Diagnostic role of p63 immunostaining in fine needle aspiration cytology of different breast lesions.
Aiad HA, Abd El-Halim Kandil M, Abd El-Wahed MM, Abdou AG, Hemida AS
Acta Cytol. 2011
PubMed ID: 21325799
MicroRNA-203 inhibits cell proliferation by repressing ΔNp63 expression in human esophageal squamous cell carcinoma.
Yuan Y, Zeng ZY, Liu XH, Gong DJ, Tao J, Cheng HZ, Huang SD
BMC Cancer. 2011
PubMed ID: 21299870
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Phenotypic analysis of Arg227 mutations of TP63 with emphasis on dental phenotype and micturition difficulties in EEC syndrome.
Sripathomsawat W, Tanpaiboon P, Heering J, Dötsch V, Hennekam RC, Kantaputra P
Am J Med Genet A. 2011
PubMed ID: 21204238
Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6.
Mukhopadhyay S, Katzenstein AL
Am J Surg Pathol. 2011
PubMed ID: 21164283
Development of thyroid gland and ultimobranchial body cyst is independent of p63.
Ozaki T, Nagashima K, Kusakabe T, Kakudo K, Kimura S
Lab Invest. 2011
PubMed ID: 20697379
Phosphorylated TP63 induces transcription of RPN13, leading to NOS2 protein degradation.
Huang Y, Ratovitski EA
J Biol Chem. 2010
PubMed ID: 20959455
TAp63 plays compensatory roles in p53-deficient cancer cells under genotoxic stress.
Yao JY, Chen JK
Biochem Biophys Res Commun. 2010
PubMed ID: 21075072
Regulation of ΔNp63α by NFκΒ.
Sen T, Chang X, Sidransky D, Chatterjee A
Cell Cycle. 2010
PubMed ID: 21088498
Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells.
LeBoeuf M, Terrell A, Trivedi S, Sinha S, Epstein JA, Olson EN, Morrisey EE, Millar SE
Dev Cell. 2010
PubMed ID: 21093383
Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells.
Huang Y, Ratovitski EA
Aging (Albany NY). 2010
PubMed ID: 21191146
Induction of ΔNp63 by the newly identified keratinocyte-specific transforming growth factor β Signaling Pathway with Smad2 and IκB Kinase α in squamous cell carcinoma.
Fukunishi N, Katoh I, Tomimori Y, Tsukinoki K, Hata R, Nakao A, Ikawa Y, Kurata S
Neoplasia. 2010
PubMed ID: 21170261
BMP signaling in the development of the mouse esophagus and forestomach.
Rodriguez P, Da Silva S, Oxburgh L, Wang F, Hogan BL, Que J
Development. 2010
PubMed ID: 21068065
Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk.
Lehmann ML, Selinski S, Blaszkewicz M, Orlich M, Ovsiannikov D, Moormann O, Guballa C, Kress A, Truss MC, Gerullis H, Otto T, Barski D, Niegisch G, Albers P, Frees S, Brenner W, Thüroff JW, Angeli-Greaves M, Seidel T, Roth G, Dietrich H, Ebbinghaus R, Prager HM, Bolt HM, Falkenstein M, Zimmermann A, Klein T, Reckwitz T, Roemer HC, Löhlein D, Weistenhöfer W, Schöps W, Beg AE, Aslam M, Bánfi G, Romics I, Ickstadt K, Schwender H, Winterpacht A, Hengstler JG, Golka K
Arch Toxicol. 2010
PubMed ID: 21063684
p63 (TP73L) a key player in embryonic urogenital development with significant dysregulation in human bladder exstrophy tissue.
Ching BJ, Wittler L, Proske J, Yagnik G, Qi L, Draaken M, Reutter H, Gearhart JP, Ludwig M, Boyadjiev SA
Int J Mol Med. 2010
PubMed ID: 21042780
The p63 target HBP1 is required for skin differentiation and stratification.
Borrelli S, Candi E, Hu B, Dolfini D, Ravo M, Grober OM, Weisz A, Dotto GP, Melino G, Viganò MA, Mantovani R
Cell Death Differ. 2010
PubMed ID: 20523354
Robust control of mitotic spindle orientation in the developing epidermis.
Poulson ND, Lechler T
J Cell Biol. 2010
PubMed ID: 21098114
YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets.
Ehsanian R, Brown M, Lu H, Yang XP, Pattatheyil A, Yan B, Duggal P, Chuang R, Doondeea J, Feller S, Sudol M, Chen Z, Van Waes C
Oncogene. 2010
PubMed ID: 20729916
Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73.
Zdzalik M, Pustelny K, Kedracka-Krok S, Huben K, Pecak A, Wladyka B, Jankowski S, Dubin A, Potempa J, Dubin G
Cell Cycle. 2010
PubMed ID: 21088494
The E3 ubiquitin ligase WWP1 regulates ΔNp63-dependent transcription through Lys63 linkages.
Peschiaroli A, Scialpi F, Bernassola F, El Sherbini el S, Melino G
Biochem Biophys Res Commun. 2010
PubMed ID: 20951678
Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
Immunohistochemical staining with deltaNp63 is useful for distinguishing the squamous cell component of adenosquamous cell carcinoma of the lung.
Uramoto H, Yamada S, Hanagiri T
Anticancer Res. 2010
PubMed ID: 21115930
ADULT syndrome caused by a mutation previously associated with EEC syndrome.
Avitan-Hersh E, Indelman M, Bergman R, Sprecher E
Pediatr Dermatol. 2010
PubMed ID: 21078104
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
Rothman N, Garcia-Closas M, Chatterjee N, Malats N, Wu X, Figueroa JD, Real FX, Van Den Berg D, Matullo G, Baris D, Thun M, Kiemeney LA, Vineis P, De Vivo I, Albanes D, Purdue MP, Rafnar T, Hildebrandt MA, Kiltie AE, Cussenot O, Golka K, Kumar R, Taylor JA, Mayordomo JI, Jacobs KB, Kogevinas M, Hutchinson A, Wang Z, Fu YP, Prokunina-Olsson L, Burdett L, Yeager M, Wheeler W, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Johnson A, Schwenn M, Karagas MR, Schned A, Andriole G, Grubb R, Black A, Jacobs EJ, Diver WR, Gapstur SM, Weinstein SJ, Virtamo J, Cortessis VK, Gago-Dominguez M, Pike MC, Stern MC, Yuan JM, Hunter DJ, McGrath M, Dinney CP, Czerniak B, Chen M, Yang H, Vermeulen SH, Aben KK, Witjes JA, Makkinje RR, Sulem P, Besenbacher S, Stefansson K, Riboli E, Brennan P, Panico S, Navarro C, Allen NE, Bueno-de-Mesquita HB, Trichopoulos D, Caporaso N, Landi MT, Canzian F, Ljungberg B, Tjonneland A, Clavel-Chapelon F, Bishop DT, Teo MT, Knowles MA, Guarrera S, Polidoro S, Ricceri F, Sacerdote C, Allione A, Cancel-Tassin G, Selinski S, Hengstler JG, Dietrich H, Fletcher T, Rudnai P, Gurzau E, Koppova K, Bolick SC, Godfrey A, Xu Z, Sanz-Velez JI, D García-Prats M, Sanchez M, Valdivia G, Porru S, Benhamou S, Hoover RN, Fraumeni JF, Silverman DT, Chanock SJ
Nat Genet. 2010
PubMed ID: 20972438
Overexpression of ΔNp63α induces a stem cell phenotype in MCF7 breast carcinoma cell line through the Notch pathway.
Du Z, Li J, Wang L, Bian C, Wang Q, Liao L, Dou X, Bian X, Zhao RC
Cancer Sci. 2010
PubMed ID: 20950370
Transcriptional activity of TAp63 promoter is regulated by c-jun.
Yao JY, Pao CC, Chen JK
J Cell Physiol. 2010
PubMed ID: 20607803
Skn-1a/Oct-11 and ΔNp63α exert antagonizing effects on human keratin expression.
Lena AM, Cipollone R, Amelio I, Catani MV, Ramadan S, Browne G, Melino G, Candi E
Biochem Biophys Res Commun. 2010
PubMed ID: 20888799
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs.
Su X, Chakravarti D, Cho MS, Liu L, Gi YJ, Lin YL, Leung ML, El-Naggar A, Creighton CJ, Suraokar MB, Wistuba I, Flores ER
Nature. 2010
PubMed ID: 20962848
Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations.
Miki D, Kubo M, Takahashi A, Yoon KA, Kim J, Lee GK, Zo JI, Lee JS, Hosono N, Morizono T, Tsunoda T, Kamatani N, Chayama K, Takahashi T, Inazawa J, Nakamura Y, Daigo Y
Nat Genet. 2010
PubMed ID: 20871597
SATB2 augments ΔNp63α in head and neck squamous cell carcinoma.
Chung J, Lau J, Cheng LS, Grant RI, Robinson F, Ketela T, Reis PP, Roche O, Kamel-Reid S, Moffat J, Ohh M, Perez-Ordonez B, Kaplan DR, Irwin MS
EMBO Rep. 2010
PubMed ID: 20829881
p63 in skin development and ectodermal dysplasias.
Koster MI
J Invest Dermatol. 2010
PubMed ID: 20445549
Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates.
Yalcin-Ozuysal O, Fiche M, Guitierrez M, Wagner KU, Raffoul W, Brisken C
Cell Death Differ. 2010
PubMed ID: 20379195
The EEC syndrome and SHFM: report of two cases and mutation analysis of p63 gene.
Ergin H, Semerci CN, Karakuş YT, Scheffer H, Ergin S, Koltuksuz U, Meijer R, Satiroğlu-Tufan NL
Turk J Pediatr. 2010
PubMed ID: 21434540
Overexpression of p63 is associated with radiation resistance and prognosis in oral squamous cell carcinoma.
Moergel M, Abt E, Stockinger M, Kunkel M
Oral Oncol. 2010
PubMed ID: 20656547
Isoforms of p63 in corneal stem cells cultured on human amniotic membrane.
Krishnan S, Sudha B, Krishnakumar S
Biologicals. 2010
PubMed ID: 20638300
Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair.
Li A, Xing Y, Chan B, Heisterkamp N, Groffen J, Borok Z, Minoo P, Li C
Dev Dyn. 2010
PubMed ID: 20658693
Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress.
Wang N, Guo L, Rueda BR, Tilly JL
EMBO Rep. 2010
PubMed ID: 20559324
PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis.
Sasaki K, Hamazaki J, Koike M, Hirano Y, Komatsu M, Uchiyama Y, Tanaka K, Murata S
Mol Cell Biol. 2010
PubMed ID: 20498273
TP63 gene mutations in Chinese P63 syndrome patients.
Yin W, Ye X, Shi L, Wang QK, Jin H, Wang P, Bian Z
J Dent Res. 2010
PubMed ID: 20410354
Clinical relevance of the putative stem cell marker p63 in breast cancer.
Hanker L, Karn T, Ruckhaeberle E, Gaetje R, Solbach C, Schmidt M, Engels K, Holtrich U, Kaufmann M, Rody A
Breast Cancer Res Treat. 2010
PubMed ID: 19898932
PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tract.
Albadine R, Schultz L, Illei P, Ertoy D, Hicks J, Sharma R, Epstein JI, Netto GJ
Am J Surg Pathol. 2010
PubMed ID: 20463571
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
DeltaNp63 transcriptionally regulates brachyury, a gene with diverse roles in limb development, tumorigenesis and metastasis.
Cho MS, Chan IL, Flores ER
Cell Cycle. 2010
PubMed ID: 20519941
Lack of interleukin-12 in p40-deficient mice leads to poor CD8+ T-cell immunity against Encephalitozoon cuniculi infection.
Moretto MM, Lawlor EM, Khan IA
Infect Immun. 2010
PubMed ID: 20308292
NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle.
Heyne K, Willnecker V, Schneider J, Conrad M, Raulf N, Schüle R, Roemer K
Nucleic Acids Res. 2010
PubMed ID: 20123734
Dominant negative (DeltaN) p63alpha induces drug resistance in hepatocellular carcinoma by interference with apoptosis signaling pathways.
Mundt HM, Stremmel W, Melino G, Krammer PH, Schilling T, Müller M
Biochem Biophys Res Commun. 2010
PubMed ID: 20403333
RNPC1, an RNA-binding protein and a target of the p53 family, regulates p63 expression through mRNA stability.
Zhang J, Jun Cho S, Chen X
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20457941
DeltaNp63alpha repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cells.
Yugawa T, Narisawa-Saito M, Yoshimatsu Y, Haga K, Ohno S, Egawa N, Fujita M, Kiyono T
Cancer Res. 2010
PubMed ID: 20442293
Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice.
Thomason HA, Zhou H, Kouwenhoven EN, Dotto GP, Restivo G, Nguyen BC, Little H, Dixon MJ, van Bokhoven H, Dixon J
J Clin Invest. 2010
PubMed ID: 20424327
A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias.
Moretti F, Marinari B, Lo Iacono N, Botti E, Giunta A, Spallone G, Garaffo G, Vernersson-Lindahl E, Merlo G, Mills AA, Ballarò C, Alemà S, Chimenti S, Guerrini L, Costanzo A
J Clin Invest. 2010
PubMed ID: 20424325
Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract.
Mao J, Kim BM, Rajurkar M, Shivdasani RA, McMahon AP
Development. 2010
PubMed ID: 20430747
TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner.
Binsky I, Lantner F, Grabovsky V, Harpaz N, Shvidel L, Berrebi A, Goldenberg DM, Leng L, Bucala R, Alon R, Haran M, Shachar I
J Immunol. 2010
PubMed ID: 20357260
A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
Kiemeney LA, Sulem P, Besenbacher S, Vermeulen SH, Sigurdsson A, Thorleifsson G, Gudbjartsson DF, Stacey SN, Gudmundsson J, Zanon C, Kostic J, Masson G, Bjarnason H, Palsson ST, Skarphedinsson OB, Gudjonsson SA, Witjes JA, Grotenhuis AJ, Verhaegh GW, Bishop DT, Sak SC, Choudhury A, Elliott F, Barrett JH, Hurst CD, de Verdier PJ, Ryk C, Rudnai P, Gurzau E, Koppova K, Vineis P, Polidoro S, Guarrera S, Sacerdote C, Campagna M, Placidi D, Arici C, Zeegers MP, Kellen E, Gutierrez BS, Sanz-Velez JI, Sanchez-Zalabardo M, Valdivia G, Garcia-Prats MD, Hengstler JG, Blaszkewicz M, Dietrich H, Ophoff RA, van den Berg LH, Alexiusdottir K, Kristjansson K, Geirsson G, Nikulasson S, Petursdottir V, Kong A, Thorgeirsson T, Mungan NA, Lindblom A, van Es MA, Porru S, Buntinx F, Golka K, Mayordomo JI, Kumar R, Matullo G, Steineck G, Kiltie AE, Aben KK, Jonsson E, Thorsteinsdottir U, Knowles MA, Rafnar T, Stefansson K
Nat Genet. 2010
PubMed ID: 20348956
Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alpha.
Romano RA, Smalley K, Liu S, Sinha S
Development. 2010
PubMed ID: 20335364
Human papillomaviruses modulate expression of microRNA 203 upon epithelial differentiation to control levels of p63 proteins.
Melar-New M, Laimins LA
J Virol. 2010
PubMed ID: 20219920
Transcriptional repression of miR-34 family contributes to p63-mediated cell cycle progression in epidermal cells.
Antonini D, Russo MT, De Rosa L, Gorrese M, Del Vecchio L, Missero C
J Invest Dermatol. 2010
PubMed ID: 20090763
Aberrant expression of a beta-catenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea.
Zhang Y, Call MK, Yeh LK, Liu H, Kochel T, Wang IJ, Chu PH, Taketo MM, Jester JV, Kao WW, Liu CY
J Cell Sci. 2010
PubMed ID: 20332116
p73 and p63 regulate the expression of fibroblast growth factor receptor 3.
Sayan AE, D'Angelo B, Sayan BS, Tucci P, Cimini A, Cerù MP, Knight RA, Melino G
Biochem Biophys Res Commun. 2010
PubMed ID: 20298673
A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network.
Lunardi A, Di Minin G, Provero P, Dal Ferro M, Carotti M, Del Sal G, Collavin L
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20308539
An immunohistochemical study of cervical neuroendocrine carcinomas: Neoplasms that are commonly TTF1 positive and which may express CK20 and P63.
McCluggage WG, Kennedy K, Busam KJ
Am J Surg Pathol. 2010
PubMed ID: 20182342
Regulation of p63 isoforms by snail and slug transcription factors in human squamous cell carcinoma.
Herfs M, Hubert P, Suarez-Carmona M, Reschner A, Saussez S, Berx G, Savagner P, Boniver J, Delvenne P
Am J Pathol. 2010
PubMed ID: 20150431
P634A4 and TAp73 immunocytochemistry in liquid-based cervical cytology--potential biomarkers for diagnosis and progress prediction of cervical neoplasia.
Cheung AN, Tsun KL, Ng KM, Szeto E, Siu MK, Wong ES, Ngan HY
Mod Pathol. 2010
PubMed ID: 20081800
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
Inactivation of HAUSP in vivo modulates p53 function.
Kon N, Kobayashi Y, Li M, Brooks CL, Ludwig T, Gu W
Oncogene. 2010
PubMed ID: 19946331
TAp63 is a transcriptional target of NF-kappaB.
Wu J, Bergholz J, Lu J, Sonenshein GE, Xiao ZX
J Cell Biochem. 2010
PubMed ID: 20052674
Cdx2 regulates patterning of the intestinal epithelium.
Grainger S, Savory JG, Lohnes D
Dev Biol. 2010
PubMed ID: 20043902
Regulation of p53 family member isoform DeltaNp63alpha by the nuclear factor-kappaB targeting kinase IkappaB kinase beta.
Chatterjee A, Chang X, Sen T, Ravi R, Bedi A, Sidransky D
Cancer Res. 2010
PubMed ID: 20145131
p63 antagonizes Wnt-induced transcription.
Drewelus I, Göpfert C, Hippel C, Dickmanns A, Damianitsch K, Pieler T, Dobbelstein M
Cell Cycle. 2010
PubMed ID: 20107313
Inactivation of the quinone oxidoreductases NQO1 and NQO2 strongly elevates the incidence and multiplicity of chemically induced skin tumors.
Shen J, Barrios RJ, Jaiswal AK
Cancer Res. 2010
PubMed ID: 20103645
Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort.
Shen L, Kim S, Risacher SL, Nho K, Swaminathan S, West JD, Foroud T, Pankratz N, Moore JH, Sloan CD, Huentelman MJ, Craig DW, Dechairo BM, Potkin SG, Jack CR, Weiner MW, Saykin AJ, the Alzheimer's Disease Neuroimaging Initiative
Neuroimage. 2010
PubMed ID: 20100581
Phospho-DeltaNp63alpha/NF-Y protein complex transcriptionally regulates DDIT3 expression in squamous cell carcinoma cells upon cisplatin exposure.
Huang Y, Chuang AY, Romano RA, Liégeois NJ, Sinha S, Trink B, Ratovitski E, Sidransky D
Cell Cycle. 2010
PubMed ID: 20023394
c-Abl phosphorylation of ΔNp63α is critical for cell viability.
Yuan M, Luong P, Hudson C, Gudmundsdottir K, Basu S
Cell Death Dis. 2010
PubMed ID: 21364617
Glucocorticoid receptor antagonizes EGFR function to regulate eyelid development.
Sanchis A, Bayo P, Sevilla LM, Pérez P
Int J Dev Biol. 2010
PubMed ID: 21136383
Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis.
Jurado S, Smyth I, van Denderen B, Tenis N, Hammet A, Hewitt K, Ng JL, McNees CJ, Kozlov SV, Oka H, Kobayashi M, Conlan LA, Cole TJ, Yamamoto K, Taniguchi Y, Takeda S, Lavin MF, Heierhorst J
PLoS Genet. 2010
PubMed ID: 20975950
Increased invasiveness and aggressiveness in breast epithelia with cytoplasmic p63 expression.
Hsiao YH, Su YA, Tsai HD, Mason JT, Chou MC, Man YG
Int J Biol Sci. 2010
PubMed ID: 20714441
Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo.
Yang A, Zhu Z, Kettenbach A, Kapranov P, McKeon F, Gingeras TR, Struhl K
PLoS One. 2010
PubMed ID: 20644729
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC
PLoS One. 2010
PubMed ID: 20634891
NAD(P)H quinone oxidoreductase protects TAp63gamma from proteasomal degradation and regulates TAp63gamma-dependent growth arrest.
Hershkovitz Rokah O, Shpilberg O, Granot G
PLoS One. 2010
PubMed ID: 20613985
The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex.
Boominathan L
PLoS One. 2010
PubMed ID: 20485546
Brdm2 - an aberrant hypomorphic p63 allele.
Talos F, Wolff S, Beyer U, Dobbelstein M, Moll UM
Cell Death Differ. 2010
PubMed ID: 20161489
Activated Ras alters lens and corneal development through induction of distinct downstream targets.
Burgess D, Zhang Y, Siefker E, Vaca R, Kuracha MR, Reneker L, Overbeek PA, Govindarajan V
BMC Dev Biol. 2010
PubMed ID: 20105280
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade.
Ma J, Meng Y, Kwiatkowski DJ, Chen X, Peng H, Sun Q, Zha X, Wang F, Wang Y, Jing Y, Zhang S, Chen R, Wang L, Wu E, Cai G, Malinowska-Kolodziej I, Liao Q, Liu Y, Zhao Y, Sun Q, Xu K, Dai J, Han J, Wu L, Zhao RC, Shen H, Zhang H
J Clin Invest. 2010
PubMed ID: 20038814
Yes-associated protein 1 regulates the stability of DeltaNp63alpha.
Chatterjee A, Sen T, Chang X, Sidransky D
Cell Cycle. 2010
PubMed ID: 20016275
Molecular basis of EEC (ectrodactyly, ectodermal dysplasia, clefting) syndrome: five new mutations in the DNA-binding domain of the TP63 gene and genotype-phenotype correlation.
Clements SE, Techanukul T, Coman D, Mellerio JE, McGrath JA
Br J Dermatol. 2010
PubMed ID: 19903181
Treasure or artifact: a decade of p63 research speaks for itself.
Mikkola ML, Costanzo A, Thesleff I, Roop DR, Koster MI
Cell Death Differ. 2010
PubMed ID: 19876067
TATA-binding Protein (TBP)-like Protein Is Engaged in Etoposide-induced Apoptosis through Transcriptional Activation of Human TAp63 Gene.
Suenaga Y, Ozaki T, Tanaka Y, Bu Y, Kamijo T, Tokuhisa T, Nakagawara A, Tamura TA
J Biol Chem. 2009
PubMed ID: 19858204
The growth-promoting effect of KGF on limbal epithelial cells is mediated by upregulation of DeltaNp63alpha through the p38 pathway.
Cheng CC, Wang DY, Kao MH, Chen JK
J Cell Sci. 2009
PubMed ID: 19920075
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
TAp63 induces senescence and suppresses tumorigenesis in vivo.
Guo X, Keyes WM, Papazoglu C, Zuber J, Li W, Lowe SW, Vogel H, Mills AA
Nat Cell Biol. 2009
PubMed ID: 19898465
Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate.
Welsh IC, O'Brien TP
Dev Biol. 2009
PubMed ID: 19782673
Conformational stability and activity of p73 require a second helix in the tetramerization domain.
Coutandin D, Löhr F, Niesen FH, Ikeya T, Weber TA, Schäfer B, Zielonka EM, Bullock AN, Yang A, Güntert P, Knapp S, McKeon F, Ou HD, Dötsch V
Cell Death Differ. 2009
PubMed ID: 19763140
p63 directly induces expression of Alox12, a regulator of epidermal barrier formation.
Kim S, Choi IF, Quante JR, Zhang L, Roop DR, Koster MI
Exp Dermatol. 2009
PubMed ID: 19555433
Palmitoylation regulates epidermal homeostasis and hair follicle differentiation.
Mill P, Lee AW, Fukata Y, Tsutsumi R, Fukata M, Keighren M, Porter RM, McKie L, Smyth I, Jackson IJ
PLoS Genet. 2009
PubMed ID: 19956733
Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study.
Stern MC, Van Den Berg D, Yuan JM, Conti DV, Gago-Dominguez M, Pike MC, Xiang YB, Gao YT, Cortessis VK
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19843673
Downregulation of DeltaNp63alpha in keratinocytes by p14ARF-mediated SUMO-conjugation and degradation.
Vivo M, Di Costanzo A, Fortugno P, Pollice A, Calabrò V, La Mantia G
Cell Cycle. 2009
PubMed ID: 19829080
p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7.
De Rosa L, Antonini D, Ferone G, Russo MT, Yu PB, Han R, Missero C
J Biol Chem. 2009
PubMed ID: 19717565
Structural evolution of p53, p63, and p73: implication for heterotetramer formation.
Joerger AC, Rajagopalan S, Natan E, Veprintsev DB, Robinson CV, Fersht AR
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19815500
Plk1 regulates liver tumor cell death by phosphorylation of TAp63.
Komatsu S, Takenobu H, Ozaki T, Ando K, Koida N, Suenaga Y, Ichikawa T, Hishiki T, Chiba T, Iwama A, Yoshida H, Ohnuma N, Nakagawara A, Kamijo T
Oncogene. 2009
PubMed ID: 19668228
Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury.
Tiozzo C, De Langhe S, Yu M, Londhe VA, Carraro G, Li M, Li C, Xing Y, Anderson S, Borok Z, Bellusci S, Minoo P
Am J Respir Crit Care Med. 2009
PubMed ID: 19574443
TAp63: The fountain of youth.
Su X, Flores ER
Aging (Albany NY). 2009
PubMed ID: 20157559
p63 and p73 transcriptionally regulate genes involved in DNA repair.
Lin YL, Sengupta S, Gurdziel K, Bell GW, Jacks T, Flores ER
PLoS Genet. 2009
PubMed ID: 19816568
Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death.
Gonfloni S, Di Tella L, Caldarola S, Cannata SM, Klinger FG, Di Bartolomeo C, Mattei M, Candi E, De Felici M, Melino G, Cesareni G
Nat Med. 2009
PubMed ID: 19783996
DeltaNp63 overexpression, alone and in combination with other biomarkers, predicts the development of oral cancer in patients with leukoplakia.
Saintigny P, El-Naggar AK, Papadimitrakopoulou V, Ren H, Fan YH, Feng L, Lee JJ, Kim ES, Hong WK, Lippman SM, Mao L
Clin Cancer Res. 2009
PubMed ID: 19773378
C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation.
Lopez RG, Garcia-Silva S, Moore SJ, Bereshchenko O, Martinez-Cruz AB, Ermakova O, Kurz E, Paramio JM, Nerlov C
Nat Cell Biol. 2009
PubMed ID: 19749746
Identification and functional characterization of two new transcriptional variants of the human p63 gene.
Mangiulli M, Valletti A, Caratozzolo MF, Tullo A, Sbisà E, Pesole G, D'Erchia AM
Nucleic Acids Res. 2009
PubMed ID: 19700772
Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis.
Li C, Li A, Li M, Xing Y, Chen H, Hu L, Tiozzo C, Anderson S, Taketo MM, Minoo P
Dev Biol. 2009
PubMed ID: 19631635
Peroxisome proliferator-activated receptor-alpha is a functional target of p63 in adult human keratinocytes.
Pozzi S, Boergesen M, Sinha S, Mandrup S, Mantovani R
J Invest Dermatol. 2009
PubMed ID: 19458633
Expression and clinical significance of S100A2 and p63 in esophageal carcinoma.
Cao LY, Yin Y, Li H, Jiang Y, Zhang HF
World J Gastroenterol. 2009
PubMed ID: 19725154
Spectrum of p63 mutations in a selected patient cohort affected with ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC).
Rinne T, Bolat E, Meijer R, Scheffer H, van Bokhoven H
Am J Med Genet A. 2009
PubMed ID: 19676060
Differential PERP regulation by TP63 mutants provides insight into AEC pathogenesis.
Beaudry VG, Pathak N, Koster MI, Attardi LD
Am J Med Genet A. 2009
PubMed ID: 19353588
Mutation analysis of p63 gene in the first Chinese family with ADULT syndrome.
Wang X, Yang J, Tao AL, Yang WL, Zhang HJ
Chin Med J (Engl). 2009
PubMed ID: 19781362
Regulation of VDR by deltaNp63alpha is associated with inhibition of cell invasion.
Kommagani R, Leonard MK, Lewis S, Romano RA, Sinha S, Kadakia MP
J Cell Sci. 2009
PubMed ID: 19622632
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut.
Goss AM, Tian Y, Tsukiyama T, Cohen ED, Zhou D, Lu MM, Yamaguchi TP, Morrisey EE
Dev Cell. 2009
PubMed ID: 19686689
Differential expression of p63 isoforms in normal skin and hyperproliferative conditions.
Kim SY, Cho HJ, Kim DS, Choi HR, Kwon SB, Na JI, Jeon HC, Huh CH, Youn SW, Cho KH, Park KC
J Cutan Pathol. 2009
PubMed ID: 19586494
Down-regulation of the apoptosis-inducing factor or Bcl-2 inhibitor of transcription by RNA interference can alleviate TAp63gamma-induced apoptosis in esophageal squamous carcinoma EC9706 cells.
Fan T, Jiang G, Suo Z, Liu H, Xu P, Ji Z, Zhang L, Yang G
Int J Oncol. 2009
PubMed ID: 19578750
A novel five-antibody immunohistochemical test for subclassification of lung carcinoma.
Ring BZ, Seitz RS, Beck RA, Shasteen WJ, Soltermann A, Arbogast S, Robert F, Schreeder MT, Ross DT
Mod Pathol. 2009
PubMed ID: 19430419
The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins.
Wolff S, Talos F, Palacios G, Beyer U, Dobbelstein M, Moll UM
Cell Death Differ. 2009
PubMed ID: 19300453
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence.
Richardson RJ, Dixon J, Jiang R, Dixon MJ
Hum Mol Genet. 2009
PubMed ID: 19439425
Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf.
Su X, Cho MS, Gi YJ, Ayanga BA, Sherr CJ, Flores ER
EMBO J. 2009
PubMed ID: 19494829
TAp63 prevents premature aging by promoting adult stem cell maintenance.
Su X, Paris M, Gi YJ, Tsai KY, Cho MS, Lin YL, Biernaskie JA, Sinha S, Prives C, Pevny LH, Miller FD, Flores ER
Cell Stem Cell. 2009
PubMed ID: 19570515
A novel TP63 mutation in family with ADULT syndrome presenting with eczema and hypothelia.
van Zelst-Stams WA, van Steensel MA
Am J Med Genet A. 2009
PubMed ID: 19530185
Notch signaling controls the balance of ciliated and secretory cell fates in developing airways.
Tsao PN, Vasconcelos M, Izvolsky KI, Qian J, Lu J, Cardoso WV
Development. 2009
PubMed ID: 19502490
Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation.
Li Y, Peart MJ, Prives C
Mol Cell Biol. 2009
PubMed ID: 19451233
Letter regarding the article: "R298Q mutation of p63 gene in autosomal dominant ectodermal dysplasia associated with arrhythmogenic right ventricular cardiomyopathy" by Valenzise et al.
van der Zwaag PA, Jongbloed JD, van den Berg MP, Jonkman MF, van Tintelen JP
Eur J Med Genet. 2009
PubMed ID: 19450441
Evidence for crucial role of hindgut expansion in directing proper migration of primordial germ cells in mouse early embryogenesis.
Hara K, Kanai-Azuma M, Uemura M, Shitara H, Taya C, Yonekawa H, Kawakami H, Tsunekawa N, Kurohmaru M, Kanai Y
Dev Biol. 2009
PubMed ID: 19371732
DeltaNp63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma.
Higashikawa K, Yoneda S, Tobiume K, Saitoh M, Taki M, Mitani Y, Shigeishi H, Ono S, Kamata N
Int J Cancer. 2009
PubMed ID: 19267405
Multiple roles for Sox2 in the developing and adult mouse trachea.
Que J, Luo X, Schwartz RJ, Hogan BL
Development. 2009
PubMed ID: 19403656
Expression of nucleosomal protein HMGN1 in the cycling mouse hair follicle.
Furusawa T, Ko JH, Birger Y, Bustin M
Gene Expr Patterns. 2009
PubMed ID: 19303948
Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation.
Golonzhka O, Liang X, Messaddeq N, Bornert JM, Campbell AL, Metzger D, Chambon P, Ganguli-Indra G, Leid M, Indra AK
J Invest Dermatol. 2009
PubMed ID: 19092943
p63 antagonizes p53 to promote the survival of embryonic neural precursor cells.
Dugani CB, Paquin A, Fujitani M, Kaplan DR, Miller FD
J Neurosci. 2009
PubMed ID: 19458240
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Immunohistochemical detection of p63 and XIAP in thymic hyperplasia and thymomas.
Wu M, Sun K, Gil J, Gan L, Burstein DE
Am J Clin Pathol. 2009
PubMed ID: 19369629
Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression.
Scheel AH, Beyer U, Agami R, Dobbelstein M
Cell Cycle. 2009
PubMed ID: 19342891
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
Homeodomain protein Dlx3 induces phosphorylation-dependent p63 degradation.
Di Costanzo A, Festa L, Duverger O, Vivo M, Guerrini L, La Mantia G, Morasso MI, Calabrò V
Cell Cycle. 2009
PubMed ID: 19282665
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis.
Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, Solari A, Bobisse S, Rondina MB, Guzzardo V, Parenti AR, Rosato A, Bicciato S, Balmain A, Piccolo S
Cell. 2009
PubMed ID: 19345189
p63 Immunoexpression in lip carcinogenesis.
Xavier FC, Takiya CM, Reis SR, Ramalho LM
J Mol Histol. 2009
PubMed ID: 19526317
Diagnostic and prognostic impact of p63 immunoreactivity in renal malignancies.
Tuna B, Unlu M, Aslan G, Secil M, Yorukoglu K
Anal Quant Cytol Histol. 2009
PubMed ID: 19402389
Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining.
Ko CJ, Leffell DJ, McNiff JM
J Cutan Pathol. 2009
PubMed ID: 19278431
Comprehensive mutational analysis and mRNA isoform quantification of TP63 in normal and neoplastic human prostate cells.
Parsons JK, Saria EA, Nakayama M, Vessella RL, Sawyers CL, Isaacs WB, Faith DA, Bova GS, Samathanam CA, Mitchell R, De Marzo AM
Prostate. 2009
PubMed ID: 19142959
Overexpression of delta Np63 in a human nasopharyngeal carcinoma cell line downregulates CKIs and enhances cell proliferation.
Chiang CT, Chu WK, Chow SE, Chen JK
J Cell Physiol. 2009
PubMed ID: 19089994
FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus.
Kameda Y, Ito M, Nishimaki T, Gotoh N
Dev Dyn. 2009
PubMed ID: 19235715
P63 expression in gestational trophoblastic disease: correlation with proliferation and apoptotic dynamics.
Zhang HJ, Xue WC, Siu MK, Liao XY, Ngan HY, Cheung AN
Int J Gynecol Pathol. 2009
PubMed ID: 19188816
Expression of the urothelial differentiation markers GATA3 and placental S100 (S100P) in female genital tract transitional cell proliferations.
Esheba GE, Longacre TA, Atkins KA, Higgins JP
Am J Surg Pathol. 2009
PubMed ID: 19092634
Antigen expression of human eccrine sweat glands.
Li HH, Zhou G, Fu XB, Zhang L
J Cutan Pathol. 2009
PubMed ID: 19032382
Oncocytic mucoepidermoid carcinoma: clinicopathologic description in a series of 12 cases.
Weinreb I, Seethala RR, Perez-Ordoñez B, Chetty R, Hoschar AP, Hunt JL
Am J Surg Pathol. 2009
PubMed ID: 18971778
P63 differentiates subtypes of nonsmall cell carcinomas of lung in cytologic samples: implications in treatment selection.
Jorda M, Gomez-Fernandez C, Garcia M, Mousavi F, Walker G, Mejias A, Fernandez-Castro G, Ganjei-Azar P
Cancer Cytopathol. 2009
PubMed ID: 19347829
Wild-type AIRE cooperates with p63 in HLA class II expression of medullary thymic stromal cells.
Tonooka A, Kubo T, Ichimiya S, Tamura Y, Ilmarinen T, Ulmanen I, Kimura S, Yokoyama S, Takano Y, Kikuchi T, Sato N
Biochem Biophys Res Commun. 2009
PubMed ID: 19124002
p63 regulates the caspase-8-FLIP apoptotic pathway in epidermis.
Borrelli S, Candi E, Alotto D, Castagnoli C, Melino G, Viganò MA, Mantovani R
Cell Death Differ. 2009
PubMed ID: 18927586
Dual regulation of TERT activity through transcription and splicing by DeltaNP63alpha.
Vorovich E, Ratovitski EA
Aging (Albany NY). 2009
PubMed ID: 20157588
E-cadherin and p63 immunoexpression in dysplastic lesions and urothelial carcinomas of the bladder.
Stepan A, Mărgăritescu C, Simionescu C, Ciurea R
Rom J Morphol Embryol. 2009
PubMed ID: 19690775
P53, p63 and Ki-67 assessment in HPV-induced cervical neoplasia.
Vasilescu F, Ceauşu M, Tănase C, Stănculescu R, Vlădescu T, Ceauşu Z
Rom J Morphol Embryol. 2009
PubMed ID: 19690760
The expression of p63 and p53 in keratoacanthoma and intraepidermal and invasive neoplasms of the skin.
Sakiz D, Turkmenoglu TT, Kabukcuoglu F
Pathol Res Pract. 2009
PubMed ID: 19577853
p63 promotes cell survival through fatty acid synthase.
Sabbisetti V, Di Napoli A, Seeley A, Amato AM, O'Regan E, Ghebremichael M, Loda M, Signoretti S
PLoS One. 2009
PubMed ID: 19517019
An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate.
Romano RA, Ortt K, Birkaya B, Smalley K, Sinha S
PLoS One. 2009
PubMed ID: 19461998
ZEB1 links p63 and p73 in a novel neuronal survival pathway rapidly induced in response to cortical ischemia.
Bui T, Sequeira J, Wen TC, Sola A, Higashi Y, Kondoh H, Genetta T
PLoS One. 2009
PubMed ID: 19194497
IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias.
Marinari B, Ballaro C, Koster MI, Giustizieri ML, Moretti F, Crosti F, Papoutsaki M, Karin M, Alema S, Chimenti S, Roop DR, Costanzo A
J Invest Dermatol. 2009
PubMed ID: 18633439
p63/p51-induced onset of keratinocyte differentiation via the c-Jun N-terminal kinase pathway is counteracted by keratinocyte growth factor.
Ogawa E, Okuyama R, Egawa T, Nagoshi H, Obinata M, Tagami H, Ikawa S, Aiba S
J Biol Chem. 2008
PubMed ID: 18849344
Genes causing clefting syndromes as candidates for non-syndromic cleft lip with or without cleft palate: a family-based association study.
Scapoli L, Martinelli M, Arlotti M, Palmieri A, Masiero E, Pezzetti F, Carinci F
Eur J Oral Sci. 2008
PubMed ID: 19049519
p63 induces CD4+ T-cell chemoattractant TARC/CCL17 in human epithelial cells.
Kubo T, Ichimiya S, Tonooka A, Nagashima T, Kikuchi T, Sato N
J Interferon Cytokine Res. 2008
PubMed ID: 18937546
False positive labeling of prostate cancer with high molecular weight cytokeratin: p63 a more specific immunomarker for basal cells.
Ali TZ, Epstein JI
Am J Surg Pathol. 2008
PubMed ID: 18813120
WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis.
Li Y, Zhou Z, Chen C
Cell Death Differ. 2008
PubMed ID: 18806757
Feasibility of immunocytochemical detection of tumor markers (XIAP, phosphohistone H1 and p63) in FNA cellblock samples from head and neck squamous cell carcinoma.
Wu M, Kafanas A, Gan L, Kohtz DS, Zhang L, Genden E, Burstein DE
Diagn Cytopathol. 2008
PubMed ID: 18831009
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer.
Kiemeney LA, Thorlacius S, Sulem P, Geller F, Aben KK, Stacey SN, Gudmundsson J, Jakobsdottir M, Bergthorsson JT, Sigurdsson A, Blondal T, Witjes JA, Vermeulen SH, Hulsbergen-van de Kaa CA, Swinkels DW, Ploeg M, Cornel EB, Vergunst H, Thorgeirsson TE, Gudbjartsson D, Gudjonsson SA, Thorleifsson G, Kristinsson KT, Mouy M, Snorradottir S, Placidi D, Campagna M, Arici C, Koppova K, Gurzau E, Rudnai P, Kellen E, Polidoro S, Guarrera S, Sacerdote C, Sanchez M, Saez B, Valdivia G, Ryk C, de Verdier P, Lindblom A, Golka K, Bishop DT, Knowles MA, Nikulasson S, Petursdottir V, Jonsson E, Geirsson G, Kristjansson B, Mayordomo JI, Steineck G, Porru S, Buntinx F, Zeegers MP, Fletcher T, Kumar R, Matullo G, Vineis P, Kiltie AE, Gulcher JR, Thorsteinsdottir U, Kong A, Rafnar T, Stefansson K
Nat Genet. 2008
PubMed ID: 18794855
Critical and distinct roles of p16 and telomerase in regulating the proliferative life span of normal human prostate epithelial progenitor cells.
Bhatia B, Jiang M, Suraneni M, Patrawala L, Badeaux M, Schneider-Broussard R, Multani AS, Jeter CR, Calhoun-Davis T, Hu L, Hu J, Tsavachidis S, Zhang W, Chang S, Hayward SW, Tang DG
J Biol Chem. 2008
PubMed ID: 18662989
[The significance of p63 expression in thyroid neoplasm].
Qian M, Wang J
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008
PubMed ID: 19160863
[Clinical significance of the expression of p53, p63 and p73 in nasal and paranasal sinus carcinoma].
Zhang T, Jia H, Wang J, Shan Y, Luo S, Tang Z
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008
PubMed ID: 19119599
[Evaluation of p63 and p504s markers for the diagnosis of prostate cancer]
Molinié V, Vieillefond A, Michiels JF, pour la commission prostate de l'AFAQAP
Ann Pathol. 2008
PubMed ID: 19068396
Impaired delta NP63 expression is associated with poor tumor development in transitional cell carcinoma of the bladder.
He Y, Wu X, Tang W, Tian D, Luo C, Yin Z, Du H
J Korean Med Sci. 2008
PubMed ID: 18955789
Regulation of p63 expression in primary and immortalized nasopharyngeal epithelial cells.
Yip YL, Tsao SW
Int J Oncol. 2008
PubMed ID: 18813784
Immunohistochemistry of p63 in primary and secondary vulvar Paget's disease.
Yanai H, Takahashi N, Omori M, Oda W, Yamadori I, Takada S, Matsuura H, Yoshino T
Pathol Int. 2008
PubMed ID: 18801085
Split hand foot malformation with whorl-like pigmentary pattern: phenotypic expression of somatic mosaicism for the p63 mutation.
Kosaki R, Naito Y, Torii C, Takahashi T, Nakajima T, Kosaki K
Am J Med Genet A. 2008
PubMed ID: 18792980
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
Differential effects of p63 mutants on transactivation of p53 and/or p63 responsive genes.
Khokhar SK, Kommagani R, Kadakia MP
Cell Res. 2008
PubMed ID: 18626511
Glycogen synthase kinase-3beta regulates DeltaNp63 gene transcription through the beta-catenin signaling pathway.
Chu WK, Dai PM, Li HL, Chen JK
J Cell Biochem. 2008
PubMed ID: 18615589
ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage.
Huang Y, Sen T, Nagpal J, Upadhyay S, Trink B, Ratovitski E, Sidransky D
Cell Cycle. 2008
PubMed ID: 18769144
p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease.
Wetzel MK, Naska S, Laliberté CL, Rymar VV, Fujitani M, Biernaskie JA, Cole CJ, Lerch JP, Spring S, Wang SH, Frankland PW, Henkelman RM, Josselyn SA, Sadikot AF, Miller FD, Kaplan DR
Neuron. 2008
PubMed ID: 18786355
Expression of cytokeratin 19 and protein p63 in fine needle aspiration biopsy of papillary thyroid carcinoma.
Bonzanini M, Amadori PL, Sagramoso C, Dalla Palma P
Acta Cytol. 2008
PubMed ID: 18833815
Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling.
Thomason HA, Dixon MJ, Dixon J
Dev Biol. 2008
PubMed ID: 18634775
R298Q mutation of p63 gene in autosomal dominant ectodermal dysplasia associated with arrhythmogenic right ventricular cardiomyopathy.
Valenzise M, Arrigo T, De Luca F, Privitera A, Frigiola A, Carando A, Garelli E, Silengo M
Eur J Med Genet. 2008
PubMed ID: 18603493
Signaling through Tgf-beta type I receptor Alk5 is required for upper lip fusion.
Li WY, Dudas M, Kaartinen V
Mech Dev. 2008
PubMed ID: 18586087
The transmembrane protein TMEM16A is required for normal development of the murine trachea.
Rock JR, Futtner CR, Harfe BD
Dev Biol. 2008
PubMed ID: 18585372
Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation.
Ugur SA, Tolun A
Hum Mol Genet. 2008
PubMed ID: 18515319
Misexpression of ELF5 disrupts lung branching and inhibits epithelial differentiation.
Metzger DE, Stahlman MT, Shannon JM
Dev Biol. 2008
PubMed ID: 18544451
The p53 homologue DeltaNp63alpha interacts with the nuclear factor-kappaB pathway to modulate epithelial cell growth.
King KE, Ponnamperuma RM, Allen C, Lu H, Duggal P, Chen Z, Van Waes C, Weinberg WC
Cancer Res. 2008
PubMed ID: 18593911
miR-203 represses 'stemness' by repressing DeltaNp63.
Lena AM, Shalom-Feuerstein R, di Val Cervo PR, Aberdam D, Knight RA, Melino G, Candi E
Cell Death Differ. 2008
PubMed ID: 18483491
Degradation of HPV20E6 by p53: Delta Np63 alpha and mutant p53R248W protect the wild type p53 mediated caspase-degradation.
Fei JW, de Villiers EM
Int J Cancer. 2008
PubMed ID: 18412244
A novel translation re-initiation mechanism for the p63 gene revealed by amino-terminal truncating mutations in Rapp-Hodgkin/Hay-Wells-like syndromes.
Rinne T, Clements SE, Lamme E, Duijf PH, Bolat E, Meijer R, Scheffer H, Rosser E, Tan TY, McGrath JA, Schalkwijk J, Brunner HG, Zhou H, van Bokhoven H
Hum Mol Genet. 2008
PubMed ID: 18364388
A chromatin immunoprecipitation screen in mouse keratinocytes reveals Runx1 as a direct transcriptional target of DeltaNp63.
Ortt K, Raveh E, Gat U, Sinha S
J Cell Biochem. 2008
PubMed ID: 18275068
Phosphorylation and stabilization of TAp63gamma by IkappaB kinase-beta.
MacPartlin M, Zeng SX, Lu H
J Biol Chem. 2008
PubMed ID: 18411264
Expression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical study.
Gurgel CA, Ramos EA, Azevedo RA, Sarmento VA, da Silva Carvalho AM, dos Santos JN
J Mol Histol. 2008
PubMed ID: 18256893
DeltaNp63/BMP-7-dependent expression of matrilin-2 is involved in keratinocyte migration in response to wounding.
Ichikawa T, Suenaga Y, Koda T, Ozaki T, Nakagawara A
Biochem Biophys Res Commun. 2008
PubMed ID: 18328806
p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck.
Gu X, Coates PJ, Boldrup L, Nylander K
Cancer Lett. 2008
PubMed ID: 18194839
Immunohistochemical detection of XIAP and p63 in adenomatous hyperplasia, atypical adenomatous hyperplasia, bronchioloalveolar carcinoma and well-differentiated adenocarcinoma.
Wu M, Orta L, Gil J, Li G, Hu A, Burstein DE
Mod Pathol. 2008
PubMed ID: 18432259
U-box-type ubiquitin E4 ligase, UFD2a attenuates cisplatin mediated degradation of DeltaNp63alpha.
Chatterjee A, Upadhyay S, Chang X, Nagpal JK, Trink B, Sidransky D
Cell Cycle. 2008
PubMed ID: 18418053
Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation.
Gontan C, de Munck A, Vermeij M, Grosveld F, Tibboel D, Rottier R
Dev Biol. 2008
PubMed ID: 18374910
Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice.
Guttormsen J, Koster MI, Stevens JR, Roop DR, Williams T, Winger QA
Dev Biol. 2008
PubMed ID: 18353300
Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells.
Li N, Singh S, Cherukuri P, Li H, Yuan Z, Ellisen LW, Wang B, Robbins D, DiRenzo J
Stem Cells. 2008
PubMed ID: 18292212
Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone.
Lee CH, Espinosa I, Jensen KC, Subramanian S, Zhu SX, Varma S, Montgomery KD, Nielsen TO, van de Rijn M, West RB
Mod Pathol. 2008
PubMed ID: 18192965
The proline-rich domain in p63 is necessary for the transcriptional and apoptosis-inducing activities of TAp63.
Helton ES, Zhang J, Chen X
Oncogene. 2008
PubMed ID: 18037962
Multiple roles of Notch signaling in the regulation of epidermal development.
Moriyama M, Durham AD, Moriyama H, Hasegawa K, Nishikawa S, Radtke F, Osawa M
Dev Cell. 2008
PubMed ID: 18410734
Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects.
Lo Iacono N, Mantero S, Chiarelli A, Garcia E, Mills AA, Morasso MI, Costanzo A, Levi G, Guerrini L, Merlo GR
Development. 2008
PubMed ID: 18326838
Immunohistochemical analysis of reserve cell-like cells of ovarian müllerian mucinous/mixed epithelial borderline tumor.
Hamada T, Kiyokawa T, Nomura K, Hano H
Int J Gynecol Pathol. 2008
PubMed ID: 18317223
Giant cell tumor of bone express p63.
Dickson BC, Li SQ, Wunder JS, Ferguson PC, Eslami B, Werier JA, Turcotte RE, Kandel RA
Mod Pathol. 2008
PubMed ID: 18311114
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
SCC-112 gene is involved in tumor progression and promotes the cell proliferation in G2/M phase.
Zheng MZ, Zheng LM, Zeng YX
J Cancer Res Clin Oncol. 2008
PubMed ID: 17846787
Transcriptional activity of the DeltaNp63 promoter is regulated by STAT3.
Chu WK, Dai PM, Li HL, Chen JK
J Biol Chem. 2008
PubMed ID: 18198175
Colorectal carcinoma-associated antigen Ca-Hb3 detected by one-dimensional SDS-polyacrylamide gel electrophoresis and liquid chromatography-tandem mass spectrometry.
Sun S, Guo FJ, Tong YQ, Zhu JG, Li GC
World J Gastroenterol. 2008
PubMed ID: 18330953
A skin microRNA promotes differentiation by repressing 'stemness'.
Yi R, Poy MN, Stoffel M, Fuchs E
Nature. 2008
PubMed ID: 18311128
Scotin: A new p63 target gene expressed during epidermal differentiation.
Zocchi L, Bourdon JC, Codispoti A, Knight R, Lane DP, Melino G, Terrinoni A
Biochem Biophys Res Commun. 2008
PubMed ID: 18164684
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
DeltaNp63 expression is associated with poor survival in ovarian cancer.
Marchini S, Marabese M, Marrazzo E, Mariani P, Cattaneo D, Fossati R, Compagnoni A, Fruscio R, Lissoni AA, Broggini M
Ann Oncol. 2008
PubMed ID: 17998283
Tprg, a Gene Predominantly Expressed in Skin, Is a Direct Target of the Transcription Factor p63.
Antonini D, Dentice M, Mahtani P, De Rosa L, Gatta GD, Mandinova A, Salvatore D, Stupka E, Missero C
J Invest Dermatol. 2008
PubMed ID: 18256694
P-cadherin is a p63 target gene with a crucial role in the developing human limb bud and hair follicle.
Shimomura Y, Wajid M, Shapiro L, Christiano AM
Development. 2008
PubMed ID: 18199584
Properties of the six isoforms of p63: p53-like regulation in response to genotoxic stress and cross talk with DeltaNp73.
Petitjean A, Ruptier C, Tribollet V, Hautefeuille A, Chardon F, Cavard C, Puisieux A, Hainaut P, Caron de Fromentel C
Carcinogenesis. 2008
PubMed ID: 18048390
p51/p63 Inhibits ultraviolet B-induced apoptosis via Akt activation.
Ogawa E, Okuyama R, Ikawa S, Nagoshi H, Egawa T, Kurihara A, Yabuki M, Tagami H, Obinata M, Aiba S
Oncogene. 2008
PubMed ID: 17653081
TAp63-dependent induction of growth differentiation factor 15 (GDF15) plays a critical role in the regulation of keratinocyte differentiation.
Ichikawa T, Suenaga Y, Koda T, Ozaki T, Nakagawara A
Oncogene. 2008
PubMed ID: 17637746
p63(TP63) elicits strong trans-activation of the MFG-E8/lactadherin/BA46 gene through interactions between the TA and DeltaN isoforms.
Okuyama T, Kurata S, Tomimori Y, Fukunishi N, Sato S, Osada M, Tsukinoki K, Jin HF, Yamashita A, Ito M, Kobayashi S, Hata RI, Ikawa Y, Katoh I
Oncogene. 2008
PubMed ID: 17637751
SCF TrCP1 activates and ubiquitylates TAp63gamma.
Gallegos JR, Litersky J, Lee H, Sun Y, Nakayama K, Nakayama K, Lu H
J Biol Chem. 2008
PubMed ID: 17965458
Prune belly anomaly on prenatal ultrasound as a presenting feature of ectrodactyly-ectodermal dysplasia-clefting syndrome (EEC).
Janssens S, Defoort P, Vandenbroecke C, Scheffer H, Mortier G
Genet Couns. 2008
PubMed ID: 19239089
An intermediate phenotype between Hay-Wells and Rapp-Hodgkin syndromes in a patient with a novel P63 mutation: confirmation of a variable phenotypic spectrum with a common aetiology.
Prontera P, Escande F, Cocchi G, Donti E, Martini A, Sensi A
Genet Couns. 2008
PubMed ID: 19239083
DeltaNp63 is essential for epidermal commitment of embryonic stem cells.
Medawar A, Virolle T, Rostagno P, de la Forest-Divonne S, Gambaro K, Rouleau M, Aberdam D
PLoS ONE. 2008
PubMed ID: 18927616
Genetic analyses in a variant of Mayer-Rokitansky-Kuster-Hauser syndrome (MURCS association).
Hofstetter G, Concin N, Marth C, Rinne T, Erdel M, Janecke A
Wien Klin Wochenschr. 2008
PubMed ID: 18726671
Claudin-1 is a p63 target gene with a crucial role in epithelial development.
Lopardo T, Lo Iacono N, Marinari B, Giustizieri ML, Cyr DG, Merlo G, Crosti F, Costanzo A, Guerrini L
PLoS ONE. 2008
PubMed ID: 18648642
Correlation of p63 immunoreactivity with tumor grade in meningiomas.
Rushing EJ, Olsen C, Man YG
Int J Surg Pathol. 2008
PubMed ID: 18203782
p63 null mutation protects mouse oocytes from radio-induced apoptosis.
Livera G, Petre-Lazar B, Guerquin MJ, Trautmann E, Coffigny H, Habert R
Reproduction. 2008
PubMed ID: 18159078
Utility of WT-1, p63, MOC31, mesothelin, and cytokeratin (K903 and CK5/6) immunostains in differentiating adenocarcinoma, squamous cell carcinoma, and malignant mesothelioma in effusions.
Pu RT, Pang Y, Michael CW
Diagn Cytopathol. 2008
PubMed ID: 18064689
Impaired repair of cyclobutane pyrimidine dimers in human keratinocytes deficient in p53 and p63.
Ferguson-Yates BE, Li H, Dong TK, Hsiao JL, Oh DH
Carcinogenesis. 2008
PubMed ID: 17984111
A novel mutation of p63 in a Chinese family with inherited syndactyly and adactylism.
Luo T, Yu W, Yuan Z, Deng Y, Zhao Y, Yuan W, Xiao J, Wang Y, Luo N, Mo X, Li Y, Liu M, Wu X
Mutat Res. 2008
PubMed ID: 17915261
Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4.
Suzuki K, Haraguchi R, Ogata T, Barbieri O, Alegria O, Vieux-Rochas M, Nakagata N, Ito M, Mills AA, Kurita T, Levi G, Yamada G
Eur J Hum Genet. 2008
PubMed ID: 17878916
CD74 induces TAp63 expression leading to B-cell survival.
Lantner F, Starlets D, Gore Y, Flaishon L, Yamit-Hezi A, Dikstein R, Leng L, Bucala R, Machluf Y, Oren M, Shachar I
Blood. 2007
PubMed ID: 17846227
p53 Family isoforms.
Bourdon JC
Curr Pharm Biotechnol. 2007
PubMed ID: 18289041
TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN.
Gu X, Coates PJ, MacCallum SF, Boldrup L, Sjöström B, Nylander K
Cancer Biol Ther. 2007
PubMed ID: 18087216
Expression pattern of p63 in oral epithelial lesions and submucous fibrosis associated with betel-quid chewing in Sri Lanka.
Haniffa AM, Saitoh M, Abiko Y, Takeshima M, Nishimura M, Yamazaki M, Nagayasu H, Sugiura C, Muthumala M, Kaku T, Chiba I, Shibata T
Med Mol Morphol. 2007
PubMed ID: 18085379
Noggin is required for normal lobe patterning and ductal budding in the mouse prostate.
Cook C, Vezina CM, Allgeier SH, Shaw A, Yu M, Peterson RE, Bushman W
Dev Biol. 2007
PubMed ID: 18028901
p63 - Key molecule in the early phase of epithelial abnormality in idiopathic pulmonary fibrosis.
Murata K, Ota S, Niki T, Goto A, Li CP, Ruriko UM, Ishikawa S, Aburatani H, Kuriyama T, Fukayama M
Exp Mol Pathol. 2007
PubMed ID: 17498688
Progression of prostate cancer from a subset of p63-positive basal epithelial cells in FG/Tag transgenic mice.
Reiner T, de Las Pozas A, Parrondo R, Perez-Stable C
Mol Cancer Res. 2007
PubMed ID: 17982114
Expression of p63 in cutaneous metastases.
Kanitakis J, Chouvet B
Am J Clin Pathol. 2007
PubMed ID: 17951196
Regeneration of the adult thymus is preceded by the expansion of K5+K8+ epithelial cell progenitors and by increased expression of Trp63, cMyc and Tcf3 transcription factors in the thymic stroma.
Popa I, Zubkova I, Medvedovic M, Romantseva T, Mostowski H, Boyd R, Zaitseva M
Int Immunol. 2007
PubMed ID: 17823311
A new mutation in TP63 is associated with age-related pathology.
Holder-Espinasse M, Martin-Coignard D, Escande F, Manouvrier-Hanu S
Eur J Hum Genet. 2007
PubMed ID: 17609671
Differential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage.
Kommagani R, Payal V, Kadakia MP
J Biol Chem. 2007
PubMed ID: 17716971
Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain.
Rojas RJ, Yohe ME, Gershburg S, Kawano T, Kozasa T, Sondek J
J Biol Chem. 2007
PubMed ID: 17606614
p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomas.
Liao XY, Xue WC, Shen DH, Ngan HY, Siu MK, Cheung AN
Histopathology. 2007
PubMed ID: 17880529
p53 and Delta Np63 alpha differentially bind and regulate target genes involved in cell cycle arrest, DNA repair and apoptosis.
Schavolt KL, Pietenpol JA
Oncogene. 2007
PubMed ID: 17404570
[Expression of GLUT-1, p63 and DNA-Pkcs in serous ovarian tumors and their significance]
Shao SL, Cai Y, Wang QH, Yan LJ, Zhao XY, Wang LX
Zhonghua Zhong Liu Za Zhi. 2007
PubMed ID: 18246802
p63 gene expression study and early bladder carcinogenesis.
Compérat E, Bièche I, Dargère D, Ferlicot S, Laurendeau I, Benoît G, Vieillefond A, Verret C, Vidaud M, Capron F, Bedossa P, Paradis V
Urology. 2007
PubMed ID: 17905096
Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development.
Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM
Dev Biol. 2007
PubMed ID: 17662267
A new E6/P63 pathway, together with a strong E7/E2F mitotic pathway, modulates the transcriptome in cervical cancer cells.
Teissier S, Ben Khalifa Y, Mori M, Pautier P, Desaintes C, Thierry F
J Virol. 2007
PubMed ID: 17582001
Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1.
Nieuwenhuis E, Barnfield PC, Makino S, Hui CC
Dev Biol. 2007
PubMed ID: 17631878
Differential p63 and p53 expression in human keloid fibroblasts and hypertrophic scar fibroblasts.
De Felice B, Ciarmiello LF, Mondola P, Damiano S, Seru R, Argenziano C, Nacca M, Santoriello M, Garbi C
DNA Cell Biol. 2007
PubMed ID: 17688405
p63 expression as a new prognostic marker in Merkel cell carcinoma.
Asioli S, Righi A, Volante M, Eusebi V, Bussolati G
Cancer. 2007
PubMed ID: 17599745
DeltaNp63alpha promotes apoptosis of human epidermal keratinocytes.
Zhu L, Rorke EA, Eckert RL
J Invest Dermatol. 2007
PubMed ID: 17392828
DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2.
Candi E, Rufini A, Terrinoni A, Giamboi-Miraglia A, Lena AM, Mantovani R, Knight R, Melino G
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17626181
Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture.
Roman S, Pétré A, Thépot A, Hautefeuille A, Scoazec JY, Mion F, Hainaut P
Am J Physiol Gastrointest Liver Physiol. 2007
PubMed ID: 17615180
p63: revving up epithelial stem-cell potential.
Blanpain C, Fuchs E
Nat Cell Biol. 2007
PubMed ID: 17603506
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm.
Que J, Okubo T, Goldenring JR, Nam KT, Kurotani R, Morrisey EE, Taranova O, Pevny LH, Hogan BL
Development. 2007
PubMed ID: 17522155
Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis.
Sayan BS, Sayan AE, Yang AL, Aqeilan RI, Candi E, Cohen GM, Knight RA, Croce CM, Melino G
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17581882
[TAp63gamma-induced apoptosis mediated by apoptosis inducing factor in human esophageal squamous carcinoma EC9706 cells]
Fan TL, Hao YB, Xu PR, Hou GQ, Jiang GZ, Yang GR
Zhonghua Bing Li Xue Za Zhi. 2007
PubMed ID: 17822623
Immunohistochemical staining of papillary breast lesions.
Troxell ML, Masek M, Sibley RK
Appl Immunohistochem Mol Morphol. 2007
PubMed ID: 17525625
p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance.
Hong SM, Cho H, Moskaluk CA, Yu E, Zaika AI
J Mol Histol. 2007
PubMed ID: 17385050
Expression of p63 in the mouse ovary.
Nakamuta N, Kobayashi S
J Reprod Dev. 2007
PubMed ID: 17317930
TAp63gamma regulates hOGG1 and repair of oxidative damage in cancer cell lines.
Upadhyay S, Chatterjee A, Trink B, Sommer M, Ratovitski E, Sidransky D
Biochem Biophys Res Commun. 2007
PubMed ID: 17399686
E2f4 is required for normal development of the airway epithelium.
Danielian PS, Bender Kim CF, Caron AM, Vasile E, Bronson RT, Lees JA
Dev Biol. 2007
PubMed ID: 17383628
p63 Is essential for the proliferative potential of stem cells in stratified epithelia.
Senoo M, Pinto F, Crum CP, McKeon F
Cell. 2007
PubMed ID: 17482546
The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers.
Leong CO, Vidnovic N, DeYoung MP, Sgroi D, Ellisen LW
J Clin Invest. 2007
PubMed ID: 17446929
A functional enhancer of keratin14 is a direct transcriptional target of deltaNp63.
Romano RA, Birkaya B, Sinha S
J Invest Dermatol. 2007
PubMed ID: 17159913
Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73.
Rother K, Dengl M, Lorenz J, Tschöp K, Kirschner R, Mössner J, Engeland K
FEBS Lett. 2007
PubMed ID: 17336302
Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition.
Yang XY, Yang TT, Schubert W, Factor SM, Chow CW
Dev Biol. 2007
PubMed ID: 17198697
Expression of p63 in thymomas and normal thymus.
Dotto J, Pelosi G, Rosai J
Am J Clin Pathol. 2007
PubMed ID: 17276940
p63 induces key target genes required for epidermal morphogenesis.
Koster MI, Dai D, Marinari B, Sano Y, Costanzo A, Karin M, Roop DR
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360634
BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms.
Mailleux AA, Overholtzer M, Schmelzle T, Bouillet P, Strasser A, Brugge JS
Dev Cell. 2007
PubMed ID: 17276340
Conflicting roles for p63 in skin development and carcinogenesis.
Koster MI, Dai D, Roop DR
Cell Cycle. 2007
PubMed ID: 17224652
Reciprocal regulation of p63 by C/EBP delta in human keratinocytes.
Borrelli S, Testoni B, Callari M, Alotto D, Castagnoli C, Romano RA, Sinha S, Viganò AM, Mantovani R
BMC Mol Biol. 2007
PubMed ID: 17903252
Novel in vivo targets of DeltaNp63 in keratinocytes identified by a modified chromatin immunoprecipitation approach.
Birkaya B, Ortt K, Sinha S
BMC Mol Biol. 2007
PubMed ID: 17521434
Prognostic significance of p53 and p63 immunolocalisation in primary and matched lymph node metastasis in oral squamous cell carcinoma.
Oliveira LR, Ribeiro-Silva A, Zucoloto S
Acta Histochem. 2007
PubMed ID: 17499344
Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasias.
Radoja N, Guerrini L, Lo Iacono N, Merlo GR, Costanzo A, Weinberg WC, La Mantia G, Calabrò V, Morasso MI
Development. 2007
PubMed ID: 17164413
The role of p63 in germ cell apoptosis in the developing testis.
Petre-Lazar B, Livera G, Moreno SG, Trautmann E, Duquenne C, Hanoux V, Habert R, Coffigny H
J Cell Physiol. 2007
PubMed ID: 16998800
TP63 gene in stress response and carcinogenesis: a broader role than expected.
Petitjean A, Hainaut P, Caron de Fromentel C
Bull Cancer. 2006
PubMed ID: 17182369
Identification of new p63 targets in human keratinocytes.
Testoni B, Borrelli S, Tenedini E, Alotto D, Castagnoli C, Piccolo S, Tagliafico E, Ferrari S, Viganò MA, Mantovani R
Cell Cycle. 2006
PubMed ID: 17172858
DeltaNp63 plays an anti-apoptotic role in ventral bladder development.
Cheng W, Jacobs WB, Zhang JJ, Moro A, Park JH, Kushida M, Qiu W, Mills AA, Kim PC
Development. 2006
PubMed ID: 17079275
DeltaNp63 protein expression in uterine cervical and endometrial cancers.
Lin Z, Liu M, Li Z, Kim C, Lee E, Kim I
J Cancer Res Clin Oncol. 2006
PubMed ID: 16804722
p63 protects the female germ line during meiotic arrest.
Suh EK, Yang A, Kettenbach A, Bamberger C, Michaelis AH, Zhu Z, Elvin JA, Bronson RT, Crum CP, McKeon F
Nature. 2006
PubMed ID: 17122775
Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells.
Yang A, Zhu Z, Kapranov P, McKeon F, Church GM, Gingeras TR, Struhl K
Mol Cell. 2006
PubMed ID: 17188034
p63 is upstream of IKK alpha in epidermal development.
Candi E, Terrinoni A, Rufini A, Chikh A, Lena AM, Suzuki Y, Sayan BS, Knight RA, Melino G
J Cell Sci. 2006
PubMed ID: 17093266
CK2-site phosphorylation of p53 is induced in DeltaNp63 expressing basal stem cells in UVB irradiated human skin.
Finlan LE, Nenutil R, Ibbotson SH, Vojtesek B, Hupp TR
Cell Cycle. 2006
PubMed ID: 17106255
Canonical notch signaling functions as a commitment switch in the epidermal lineage.
Blanpain C, Lowry WE, Pasolli HA, Fuchs E
Genes Dev. 2006
PubMed ID: 17079689
Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia.
Tian J, Mahmood R, Hnasko R, Locker J
Cancer Res. 2006
PubMed ID: 17079460
Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch.
Richardson RJ, Dixon J, Malhotra S, Hardman MJ, Knowles L, Boot-Handford RP, Shore P, Whitmarsh A, Dixon MJ
Nat Genet. 2006
PubMed ID: 17041603
Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6).
Ingraham CR, Kinoshita A, Kondo S, Yang B, Sajan S, Trout KJ, Malik MI, Dunnwald M, Goudy SL, Lovett M, Murray JC, Schutte BC
Nat Genet. 2006
PubMed ID: 17041601
New p63 targets in keratinocytes identified by a genome-wide approach.
Viganò MA, Lamartine J, Testoni B, Merico D, Alotto D, Castagnoli C, Robert A, Candi E, Melino G, Gidrol X, Mantovani R
EMBO J. 2006
PubMed ID: 17036050
p63 overexpression induces the expression of Sonic Hedgehog.
Caserta TM, Kommagani R, Yuan Z, Robbins DJ, Mercer CA, Kadakia MP
Mol Cancer Res. 2006
PubMed ID: 17050669
p53 family members in myogenic differentiation and rhabdomyosarcoma development.
Cam H, Griesmann H, Beitzinger M, Hofmann L, Beinoraviciute-Kellner R, Sauer M, Hüttinger-Kirchhof N, Oswald C, Friedl P, Gattenlöhner S, Burek C, Rosenwald A, Stiewe T
Cancer Cell. 2006
PubMed ID: 17045206
Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma.
DeYoung MP, Johannessen CM, Leong CO, Faquin W, Rocco JW, Ellisen LW
Cancer Res. 2006
PubMed ID: 17018588
Immunohistochemical detection of p63 in testicular germ cell neoplasia.
Emanuel PO, Unger PD, Burstein DE
Ann Diagn Pathol. 2006
PubMed ID: 16979518
Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family.
Xu Y, Chen X
J Biol Chem. 2006
PubMed ID: 16831876
DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse.
Sommer M, Poliak N, Upadhyay S, Ratovitski E, Nelkin BD, Donehower LA, Sidransky D
Cell Cycle. 2006
PubMed ID: 16940753
Gli3-mediated repression of Hedgehog targets is required for normal mammary development.
Hatsell SJ, Cowin P
Development. 2006
PubMed ID: 16914490
The E3 ubiquitin ligase Itch controls the protein stability of p63.
Rossi M, Aqeilan RI, Neale M, Candi E, Salomoni P, Knight RA, Croce CM, Melino G
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16908849
Expression of p63 transcription factor in ectoderm-derived oral tissues.
Casasco M, Icaro Cornaglia A, Riva F, Calligaro A, Casasco A
Ital J Anat Embryol. 2006
PubMed ID: 17312919
GLUT1 and p63 expression in endometrial intraepithelial and uterine serous papillary carcinoma.
Idrees MT, Schlosshauer P, Li G, Burstein DE
Histopathology. 2006
PubMed ID: 16842248
Defining the regulatory elements in the proximal promoter of DeltaNp63 in keratinocytes: Potential roles for Sp1/Sp3, NF-Y, and p63.
Romano RA, Birkaya B, Sinha S
J Invest Dermatol. 2006
PubMed ID: 16645595
Identification of vitamin D receptor as a target of p63.
Kommagani R, Caserta TM, Kadakia MP
Oncogene. 2006
PubMed ID: 16462763
S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation.
Lapi E, Iovino A, Fontemaggi G, Soliera AR, Iacovelli S, Sacchi A, Rechavi G, Givol D, Blandino G, Strano S
Oncogene. 2006
PubMed ID: 16449968
A mutation of the p63 gene in non-syndromic cleft lip.
Leoyklang P, Siriwan P, Shotelersuk V
J Med Genet. 2006
PubMed ID: 16740912
p63 regulates an adhesion programme and cell survival in epithelial cells.
Carroll DK, Carroll JS, Leong CO, Cheng F, Brown M, Mills AA, Brugge JS, Ellisen LW
Nat Cell Biol. 2006
PubMed ID: 16715076
p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress.
Murray-Zmijewski F, Lane DP, Bourdon JC
Cell Death Differ. 2006
PubMed ID: 16601753
Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice.
Candi E, Rufini A, Terrinoni A, Dinsdale D, Ranalli M, Paradisi A, De Laurenzi V, Spagnoli LG, Catani MV, Ramadan S, Knight RA, Melino G
Cell Death Differ. 2006
PubMed ID: 16601749
The role of p53 protein family in gastrointestinal malignancies.
Zaika AI, El-Rifai W
Cell Death Differ. 2006
PubMed ID: 16557273
p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.
Keyes WM, Vogel H, Koster MI, Guo X, Qi Y, Petherbridge KM, Roop DR, Bradley A, Mills AA
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16714381
A dominant negative form of p63 inhibits apoptosis in a p53-independent manner.
Lee HO, Lee JH, Choi E, Seol JY, Yun Y, Lee H
Biochem Biophys Res Commun. 2006
PubMed ID: 16616891
Immunodetection of GLUT1, p63 and phospho-histone H1 in invasive head and neck squamous carcinoma: correlation of immunohistochemical staining patterns with keratinization.
Burstein DE, Nagi C, Kohtz DS, Lee L, Wang B
Histopathology. 2006
PubMed ID: 16681688
Immunohistochemical detection of GLUT1, p63 and phosphorylated histone H1 in head and neck squamous intraepithelial neoplasia: evidence for aberrations in hypoxia-related, cell cycle- and stem-cell-regulatory pathways.
Burstein DE, Nagi C, Kohtz DS, Lumerman H, Wang BY
Histopathology. 2006
PubMed ID: 16681687
Immunohistochemical expression of p16, p53, and p63 in colorectal adenomas and adenocarcinomas.
Carneiro FP, Ramalho LN, Britto-Garcia S, Ribeiro-Silva A, Zucoloto S
Dis Colon Rectum. 2006
PubMed ID: 16575619
Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid.
Kusakabe T, Hoshi N, Kimura S
Dev Dyn. 2006
PubMed ID: 16342117
The DNA sequence, annotation and analysis of human chromosome 3.
Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA
Nature. 2006
PubMed ID: 16641997
Dual regulation of the DeltaNp63 transcriptional activity by DeltaNp63 in human nasopharyngeal carcinoma cell.
Chu WK, Lee KC, Chow SE, Chen JK
Biochem Biophys Res Commun. 2006
PubMed ID: 16516862
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation.
Nguyen BC, Lefort K, Mandinova A, Antonini D, Devgan V, Della Gatta G, Koster MI, Zhang Z, Wang J, Tommasi di Vignano A, Kitajewski J, Chiorino G, Roop DR, Missero C, Dotto GP
Genes Dev. 2006
PubMed ID: 16618808
Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression.
Koster MI, Lu SL, White LD, Wang XJ, Roop DR
Cancer Res. 2006
PubMed ID: 16618715
The expression of p63 in basal cell carcinomas and association with histological differentiation.
Bircan S, Candir O, Kapucoglu N, Baspinar S
J Cutan Pathol. 2006
PubMed ID: 16630179
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer.
Antonini D, Rossi B, Han R, Minichiello A, Di Palma T, Corrado M, Banfi S, Zannini M, Brissette JL, Missero C
Mol Cell Biol. 2006
PubMed ID: 16581802
p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation.
Laurikkala J, Mikkola ML, James M, Tummers M, Mills AA, Thesleff I
Development. 2006
PubMed ID: 16524929
p63 and epithelial biology.
Barbieri CE, Pietenpol JA
Exp Cell Res. 2006
PubMed ID: 16406339
GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner.
Yan W, Chen X
J Biol Chem. 2006
PubMed ID: 16446369
Downregulation of TAp63 and unaffected levels of p63beta distinguishes oral wounds from SCCHN.
Thurfjell N, Coates PJ, Wahlin YB, Arvidsson E, Nylander K
Cell Cycle. 2006
PubMed ID: 16481749
Immunohistochemical expression of p63, p53 and MIB-1 in urinary bladder carcinoma. A tissue microarray study of 158 cases.
Compérat E, Camparo P, Haus R, Chartier-Kastler E, Bart S, Delcourt A, Houlgatte A, François R, Capron F, Vieillefond A
Virchows Arch. 2006
PubMed ID: 16283378
Loss of p63 and cytokeratin 5/6 expression is associated with more aggressive tumors in endometrial carcinoma patients.
Stefansson IM, Salvesen HB, Akslen LA
Int J Cancer. 2006
PubMed ID: 16152605
p63 protein is essential for the embryonic development of vibrissae and teeth.
Rufini A, Weil M, McKeon F, Barlattani A, Melino G, Candi E
Biochem Biophys Res Commun. 2006
PubMed ID: 16410075
The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63.
Helton ES, Zhu J, Chen X
J Biol Chem. 2006
PubMed ID: 16319057
[The clinical significance of the expression of p63 gene in laryngeal squamous cell carcinoma].
Jia H, Wang J, Shan Y, Hou J
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006
PubMed ID: 16646404
A role for chromosomal protein HMGN1 in corneal maturation.
Birger Y, Davis J, Furusawa T, Rand E, Piatigorsky J, Bustin M
Differentiation. 2006
PubMed ID: 16466397
A novel response element confers p63- and p73-specific activation of the WNT4 promoter.
Osada M, Park HL, Nagakawa Y, Begum S, Yamashita K, Wu G, Kim MS, Trink B, Sidransky D
Biochem Biophys Res Commun. 2006
PubMed ID: 16343436
Periacinar Clefting and p63 Immunostaining in Prostatic Intraepithelial Neoplasia and Prostatic Carcinoma.
Kruslin B, Tomas D, Cviko A, Cupic H, Odak L, Belicza M
Pathol Oncol Res. 2006
PubMed ID: 17189982
NMR structure of the p63 SAM domain and dynamical properties of G534V and T537P pathological mutants, identified in the AEC syndrome.
Cicero DO, Falconi M, Candi E, Mele S, Cadot B, Di Venere A, Rufini S, Melino G, Desideri A
Cell Biochem Biophys. 2006
PubMed ID: 16679535
Dysregulation of TAp63 mRNA and protein levels in psoriasis.
Gu X, Lundqvist EN, Coates PJ, Thurfjell N, Wettersand E, Nylander K
J Invest Dermatol. 2006
PubMed ID: 16417229
p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis.
Rocco JW, Leong CO, Kuperwasser N, DeYoung MP, Ellisen LW
Cancer Cell. 2006
PubMed ID: 16413471
Connecting p63 to cellular proliferation: the example of the adenosine deaminase target gene.
Sbisà E, Mastropasqua G, Lefkimmiatis K, Caratozzolo MF, D'Erchia AM, Tullo A
Cell Cycle. 2006
PubMed ID: 16410722
TAp63alpha induces AP-2gamma as an early event in epidermal morphogenesis.
Koster MI, Kim S, Huang J, Williams T, Roop DR
Dev Biol. 2006
PubMed ID: 16324689
The Hay Wells syndrome-derived TAp63alphaQ540L mutant has impaired transcriptional and cell growth regulatory activity.
Lo Iacono M, Di Costanzo A, Calogero RA, Mansueto G, Saviozzi S, Crispi S, Pollice A, La Mantia G, Calabrò V
Cell Cycle. 2006
PubMed ID: 16319531
Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis.
King KE, Ponnamperuma RM, Gerdes MJ, Tokino T, Yamashita T, Baker CC, Weinberg WC
Carcinogenesis. 2006
PubMed ID: 16081516
p63 is an essential proapoptotic protein during neural development.
Jacobs WB, Govoni G, Ho D, Atwal JK, Barnabe-Heider F, Keyes WM, Mills AA, Miller FD, Kaplan DR
Neuron. 2005
PubMed ID: 16337913
Antibodies targeting p63 react specifically in the cytoplasm of breast epithelial cells exhibiting secretory differentiation.
Bratthauer GL, Saenger JS, Strauss BL
Histopathology. 2005
PubMed ID: 16324199
The p53-homologue p63 may promote thyroid cancer progression.
Malaguarnera R, Mandarino A, Mazzon E, Vella V, Gangemi P, Vancheri C, Vigneri P, Aloisi A, Vigneri R, Frasca F
Endocr Relat Cancer. 2005
PubMed ID: 16322335
Endogenous p63 acts as a survival factor for tumour cells of SCCHN origin.
Thurfjell N, Coates PJ, Vojtesek B, Benham-Motlagh P, Eisold M, Nylander K
Int J Mol Med. 2005
PubMed ID: 16273287
The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells.
Nahor I, Abramovitch S, Engeland K, Werner H
Growth Horm IGF Res. 2005
PubMed ID: 16181796
deltaEF1 repressor controls selectively p53 family members during differentiation.
Fontemaggi G, Gurtner A, Damalas A, Costanzo A, Higashi Y, Sacchi A, Strano S, Piaggio G, Blandino G
Oncogene. 2005
PubMed ID: 16007124
Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles.
Kulesz-Martin M, Lagowski J, Fei S, Pelz C, Sears R, Powell MB, Halaban R, Johnson J
J Investig Dermatol Symp Proc. 2005
PubMed ID: 16363065
Regulation of the cyclin-dependent kinase inhibitor p57Kip2 expression by p63.
Beretta C, Chiarelli A, Testoni B, Mantovani R, Guerrini L
Cell Cycle. 2005
PubMed ID: 16258268
The promyelocytic leukaemia protein tumour suppressor functions as a transcriptional regulator of p63.
Bernassola F, Oberst A, Melino G, Pandolfi PP
Oncogene. 2005
PubMed ID: 16007146
The differential regulation of human telomerase reverse transcriptase and vascular endothelial growth factor may contribute to the clinically more aggressive behavior of p63-positive breast carcinomas.
Ribeiro-Silva A, Becker de Moura H, Ribeiro do Vale F, Zucoloto S
Int J Biol Markers. 2005
PubMed ID: 16398404
p63 expression in salivary gland tumors: role of DeltaNp73L in neoplastic transformation.
Foschini MP, Gaiba A, Cocchi R, Pennesi MG, Pession A
Int J Surg Pathol. 2005
PubMed ID: 16273188
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
[Expression and biological significance of survivin and p63 in laryngeal squamous cell carcinoma].
Wen X, Gao Y, Ji W
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005
PubMed ID: 16375115
Dlx genes, p63, and ectodermal dysplasias.
Morasso MI, Radoja N
Birth Defects Res C Embryo Today. 2005
PubMed ID: 16187309
Expression of beta-catenin, p63 and CD34 in hair follicles during the course of androgenetic alopecia.
Fiuraskova M, Brychtova S, Kolar Z, Kucerova R, Bienova M
Arch Dermatol Res. 2005
PubMed ID: 16133456
p63 deficiency activates a program of cellular senescence and leads to accelerated aging.
Keyes WM, Wu Y, Vogel H, Guo X, Lowe SW, Mills AA
Genes Dev. 2005
PubMed ID: 16107615
Expression of p63 in diffuse large B-cell lymphoma.
Hedvat CV, Teruya-Feldstein J, Puig P, Capodieci P, Dudas M, Pica N, Qin J, Cordon-Cardo C, Di Como CJ
Appl Immunohistochem Mol Morphol. 2005
PubMed ID: 16082248
Differential expression of p63 isoforms in female reproductive organs.
Kurita T, Cunha GR, Robboy SJ, Mills AA, Medina RT
Mech Dev. 2005
PubMed ID: 15922574
p300 regulates p63 transcriptional activity.
MacPartlin M, Zeng S, Lee H, Stauffer D, Jin Y, Thayer M, Lu H
J Biol Chem. 2005
PubMed ID: 15965232
p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo.
Perez-Losada J, Wu D, DelRosario R, Balmain A, Mao JH
Oncogene. 2005
PubMed ID: 16007185
p63 regulates commitment to the prostate cell lineage.
Signoretti S, Pires MM, Lindauer M, Horner JW, Grisanzio C, Dhar S, Majumder P, McKeon F, Kantoff PW, Sellers WR, Loda M
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16051706
Developmental and cellular factors underlying corneal epithelial dysgenesis in the Pax6+/- mouse model of aniridia.
Ramaesh T, Ramaesh K, Martin Collinson J, Chanas SA, Dhillon B, West JD
Exp Eye Res. 2005
PubMed ID: 16080917
Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation.
Gao N, Ishii K, Mirosevich J, Kuwajima S, Oppenheimer SR, Roberts RL, Jiang M, Yu X, Shappell SB, Caprioli RM, Stoffel M, Hayward SW, Matusik RJ
Development. 2005
PubMed ID: 15987773
TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria.
Gressner O, Schilling T, Lorenz K, Schulze Schleithoff E, Koch A, Schulze-Bergkamen H, Lena AM, Candi E, Terrinoni A, Catani MV, Oren M, Melino G, Krammer PH, Stremmel W, Müller M
EMBO J. 2005
PubMed ID: 15944736
Isoforms of DeltaNp63 and the migration of ocular limbal cells in human corneal regeneration.
Di Iorio E, Barbaro V, Ruzza A, Ponzin D, Pellegrini G, De Luca M
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15983386
DNA-binding and transactivation activities are essential for TAp63 protein degradation.
Ying H, Chang DL, Zheng H, McKeon F, Xiao ZX
Mol Cell Biol. 2005
PubMed ID: 15988026
Differential recognition of response elements determines target gene specificity for p53 and p63.
Osada M, Park HL, Nagakawa Y, Yamashita K, Fomenkov A, Kim MS, Wu G, Nomoto S, Trink B, Sidransky D
Mol Cell Biol. 2005
PubMed ID: 15988020
p63-specific activation of the BPAG-1e promoter.
Osada M, Nagakawa Y, Park HL, Yamashita K, Wu G, Kim MS, Fomenkov A, Trink B, Sidransky D
J Invest Dermatol. 2005
PubMed ID: 15982302
Destabilization of DeltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo.
Bakkers J, Camacho-Carvajal M, Nowak M, Kramer C, Danger B, Hammerschmidt M
Cell Cycle. 2005
PubMed ID: 15908775
Ectoderm-targeted overexpression of the glucocorticoid receptor induces hypohidrotic ectodermal dysplasia.
Cascallana JL, Bravo A, Donet E, Leis H, Lara MF, Paramio JM, Jorcano JL, Pérez P
Endocrinology. 2005
PubMed ID: 15746257
The soluble p51 protein in cancer diagnosis, prevention and therapy.
Zusman I
In Vivo. 2005
PubMed ID: 15875781
Ultraviolet radiation induces phosphorylation and ubiquitin-mediated degradation of DeltaNp63alpha.
Westfall MD, Joyner AS, Barbieri CE, Livingstone M, Pietenpol JA
Cell Cycle. 2005
PubMed ID: 15846104
p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma.
Emanuel P, Wang B, Wu M, Burstein DE
Mod Pathol. 2005
PubMed ID: 15529180
TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressor.
Spiesbach K, Tannapfel A, Mössner J, Engeland K
Int J Cancer. 2005
PubMed ID: 15578720
Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family.
Flores ER, Sengupta S, Miller JB, Newman JJ, Bronson R, Crowley D, Yang A, McKeon F, Jacks T
Cancer Cell. 2005
PubMed ID: 15837625
Perp is a p63-regulated gene essential for epithelial integrity.
Ihrie RA, Marques MR, Nguyen BT, Horner JS, Papazoglu C, Bronson RT, Mills AA, Attardi LD
Cell. 2005
PubMed ID: 15797384
Interaction of microtubule-associated protein-2 and p63: a new link between microtubules and rough endoplasmic reticulum membranes in neurons.
Farah CA, Liazoghli D, Perreault S, Desjardins M, Guimont A, Anton A, Lauzon M, Kreibich G, Paiement J, Leclerc N
J Biol Chem. 2005
PubMed ID: 15623521
Copy number changes of target genes in chromosome 3q25.3-qter of esophageal squamous cell carcinoma: TP63 is amplified in early carcinogenesis but down-regulated as disease progressed.
Yen CC, Chen YJ, Pan CC, Lu KH, Chen PC, Hsia JY, Chen JT, Wu YC, Hsu WH, Wang LS, Huang MH, Huang BS, Hu CP, Chen PM, Lin CH
World J Gastroenterol. 2005
PubMed ID: 15761962
Distinct functions for Bmp signaling in lip and palate fusion in mice.
Liu W, Sun X, Braut A, Mishina Y, Behringer RR, Mina M, Martin JF
Development. 2005
PubMed ID: 15716346
A dual fate of the hindlimb muscle mass: cloacal/perineal musculature develops from leg muscle cells.
Valasek P, Evans DJ, Maina F, Grim M, Patel K
Development. 2005
PubMed ID: 15653949
Dominant-negative retinoic acid receptors elicit epidermal defects through a non-canonical pathway.
Chen CF, Lohnes D
J Biol Chem. 2005
PubMed ID: 15528198
The expression of TA and DeltaNp63 are regulated by different mechanisms in liver cells.
Petitjean A, Cavard C, Shi H, Tribollet V, Hainaut P, Caron de Fromentel C
Oncogene. 2005
PubMed ID: 15543231
Expression of different p63 variants in healing skin wounds suggests a role of p63 in reepithelialization and muscle repair.
Bamberger C, Hafner A, Schmale H, Werner S
Wound Repair Regen. 2005
PubMed ID: 15659035
The protein stability and transcriptional activity of p63alpha are regulated by SUMO-1 conjugation.
Ghioni P, D'Alessandra Y, Mansueto G, Jaffray E, Hay RT, La Mantia G, Guerrini L
Cell Cycle. 2005
PubMed ID: 15611636
Expression of p63 in primary cutaneous adnexal neoplasms and adenocarcinoma metastatic to the skin.
Ivan D, Hafeez Diwan A, Prieto VG
Mod Pathol. 2005
PubMed ID: 15389254
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
Lang GA, Iwakuma T, Suh YA, Liu G, Rao VA, Parant JM, Valentin-Vega YA, Terzian T, Caldwell LC, Strong LC, El-Naggar AK, Lozano G
Cell. 2004
PubMed ID: 15607981
Altered sumoylation of p63alpha contributes to the split-hand/foot malformation phenotype.
Huang YP, Wu G, Guo Z, Osada M, Fomenkov T, Park HL, Trink B, Sidransky D, Fomenkov A, Ratovitski EA
Cell Cycle. 2004
PubMed ID: 15539951
p51/p63 Controls subunit alpha3 of the major epidermis integrin anchoring the stem cells to the niche.
Kurata S, Okuyama T, Osada M, Watanabe T, Tomimori Y, Sato S, Iwai A, Tsuji T, Ikawa Y, Katoh I
J Biol Chem. 2004
PubMed ID: 15361520
Expression of p63 in the mouse primordial germ cells.
Nakamuta N, Kobayashi S
J Vet Med Sci. 2004
PubMed ID: 15585950
p63 expression in breast cancer: a highly sensitive and specific marker of metaplastic carcinoma.
Koker MM, Kleer CG
Am J Surg Pathol. 2004
PubMed ID: 15489655
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
RACK1 and stratifin target DeltaNp63alpha for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage.
Fomenkov A, Zangen R, Huang YP, Osada M, Guo Z, Fomenkov T, Trink B, Sidransky D, Ratovitski EA
Cell Cycle. 2004
PubMed ID: 15467455
Role of p63 and basal cells in the prostate.
Kurita T, Medina RT, Mills AA, Cunha GR
Development. 2004
PubMed ID: 15371309
An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis.
Adolphe C, Narang M, Ellis T, Wicking C, Kaur P, Wainwright B
Development. 2004
PubMed ID: 15371305
Neuronal survival and p73/p63/p53: a family affair.
Jacobs WB, Walsh GS, Miller FD
Neuroscientist. 2004
PubMed ID: 15359011
The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis.
Weston CR, Wong A, Hall JP, Goad ME, Flavell RA, Davis RJ
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15375216
P63 expression in lung carcinoma: a tissue microarray study of 408 cases.
Au NH, Gown AM, Cheang M, Huntsman D, Yorida E, Elliott WM, Flint J, English J, Gilks CB, Grimes HL
Appl Immunohistochem Mol Morphol. 2004
PubMed ID: 15551738
Age-related expressions of p63 and other keratinocyte stem cell markers in rat cornea.
Hsueh YJ, Wang DY, Cheng CC, Chen JK
J Biomed Sci. 2004
PubMed ID: 15316140
Expression of the p63 and Notch signaling systems in rat testes during postnatal development: comparison with their expression levels in the epididymis and vas deferens.
Hayashi T, Yoshinaga A, Ohno R, Ishii N, Kamata S, Yamada T
J Androl. 2004
PubMed ID: 15292098
Ubiquitous p63 expression in human esophageal squamous cell carcinoma.
Hara T, Kijima H, Yamamoto S, Kenmochi T, Kise Y, Tanaka H, Chino O, Shimada H, Takazawa K, Tanaka M, Inokuchi S, Makuuchi H
Int J Mol Med. 2004
PubMed ID: 15254760
p63 and p73: roles in development and tumor formation.
Moll UM, Slade N
Mol Cancer Res. 2004
PubMed ID: 15280445
p63 and p73 are not required for the development and p53-dependent apoptosis of T cells.
Senoo M, Manis JP, Alt FW, McKeon F
Cancer Cell. 2004
PubMed ID: 15261144
Complex p63 mRNA isoform expression patterns in squamous cell carcinoma of the head and neck.
Thurfjell N, Coates PJ, Uusitalo T, Mahani D, Dabelsteen E, Dahlqvist A, Sjöström B, Roos G, Nylander K
Int J Oncol. 2004
PubMed ID: 15201986
Molecular evidence that AEC syndrome and Rapp-Hodgkin syndrome are variable expression of a single genetic disorder.
Bertola DR, Kim CA, Albano LM, Scheffer H, Meijer R, van Bokhoven H
Clin Genet. 2004
PubMed ID: 15200513
Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium.
Daniely Y, Liao G, Dixon D, Linnoila RI, Lori A, Randell SH, Oren M, Jetten AM
Am J Physiol Cell Physiol. 2004
PubMed ID: 15189821
p63: Molecular complexity in development and cancer.
Westfall MD, Pietenpol JA
Carcinogenesis. 2004
PubMed ID: 15033906
p63 expression in sclerosing mucoepidermoid carcinomas with eosinophilia arising in the thyroid.
Hunt JL, LiVolsi VA, Barnes EL
Mod Pathol. 2004
PubMed ID: 15001991
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
p63 expression in benign and malignant breast lesions.
Stefanou D, Batistatou A, Nonni A, Arkoumani E, Agnantis NJ
Histol Histopathol. 2004
PubMed ID: 15024707
Roles of p63 in the diethylstilbestrol-induced cervicovaginal adenosis.
Kurita T, Mills AA, Cunha GR
Development. 2004
PubMed ID: 14998922
Expression of p53 family in scars.
Tanaka A, Hatoko M, Tada H, Iioka H, Niitsuma K, Miyagawa S
J Dermatol Sci. 2004
PubMed ID: 14757278
The role of p63 in development and differentiation of the epidermis.
Koster MI, Roop DR
J Dermatol Sci. 2004
PubMed ID: 14757276
ASPP1 and ASPP2: common activators of p53 family members.
Bergamaschi D, Samuels Y, Jin B, Duraisingham S, Crook T, Lu X
Mol Cell Biol. 2004
PubMed ID: 14729977
p63 is the molecular switch for initiation of an epithelial stratification program.
Koster MI, Kim S, Mills AA, DeMayo FJ, Roop DR
Genes Dev. 2004
PubMed ID: 14729569
p63 gene analysis in Mexican patients with syndromic and non-syndromic ectrodactyly.
Berdón-Zapata V, Granillo-Alvarez M, Valdés-Flores M, García-Ortiz JE, Kofman-Alfaro S, Zenteno JC
J Orthop Res. 2004
PubMed ID: 14656652
Delta Np63 alpha expression is regulated by the phosphoinositide 3-kinase pathway.
Barbieri CE, Barton CE, Pietenpol JA
J Biol Chem. 2003
PubMed ID: 14555649
Rapp-Hodgkin and AEC syndromes due to a new frameshift mutation in the TP63 gene.
Dianzani I, Garelli E, Gustavsson P, Carando A, Gustafsson B, Dahl N, Annerén G
J Med Genet. 2003
PubMed ID: 14684701
Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder.
Koga F, Kawakami S, Fujii Y, Saito K, Ohtsuka Y, Iwai A, Ando N, Takizawa T, Kageyama Y, Kihara K
Clin Cancer Res. 2003
PubMed ID: 14654529
The Role of p63 and p73 in tumor formation and progression: coming of age toward clinical usefulness. Commentary re: F. Koga et al., Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of th
Moll UM
Clin Cancer Res. 2003
PubMed ID: 14654522
P63 and EGFR as prognostic predictors in stage IIB radiation-treated cervical squamous cell carcinoma.
Cho NH, Kim YB, Park TK, Kim GE, Park K, Song KJ
Gynecol Oncol. 2003
PubMed ID: 14599865
p73 and p63 protein stability: the way to regulate function?
Maisse C, Guerrieri P, Melino G
Biochem Pharmacol. 2003
PubMed ID: 14555234
Sp8 is crucial for limb outgrowth and neuropore closure.
Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14526104
Differential expression of p53, p63 and p73 proteins in human buccal squamous-cell carcinomas.
Chen YK, Huse SS, Lin LM
Clin Otolaryngol Allied Sci. 2003
PubMed ID: 12969350
Identification of S100A2 as a target of the DeltaNp63 oncogenic pathway.
Hibi K, Fujitake S, Takase T, Kodera Y, Ito K, Akiyama S, Shirane M, Nakao A
Clin Cancer Res. 2003
PubMed ID: 14519656
Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML.
Kim EJ, Park JS, Um SJ
Nucleic Acids Res. 2003
PubMed ID: 12954772
FGF-10 plays an essential role in the growth of the fetal prostate.
Donjacour AA, Thomson AA, Cunha GR
Dev Biol. 2003
PubMed ID: 12941620
The Rapp-Hodgkin syndrome results from mutations of the TP63 gene.
Bougeard G, Hadj-Rabia S, Faivre L, Sarafan-Vasseur N, Frébourg T
Eur J Hum Genet. 2003
PubMed ID: 12939657
Expression of p63 in the testis of mouse embryos.
Nakamuta N, Kobayashi S
J Vet Med Sci. 2003
PubMed ID: 12951416
Backbone 1H, 13C and 15N resonance assignments for the 25.8 kDa DNA binding domain of the human p63 protein.
Furrer J, Enthart A, Kühlewein A, Dehner A, Klein C, Hansen S, Schwaiger M, Kessler H, Gemmecker G
J Biomol NMR. 2003
PubMed ID: 12815266
EEC syndrome type 3 with a heterozygous germline mutation in the P63 gene and B cell lymphoma.
Akahoshi K, Sakazume S, Kosaki K, Ohashi H, Fukushima Y
Am J Med Genet A. 2003
PubMed ID: 12838557
P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome.
Fomenkov A, Huang YP, Topaloglu O, Brechman A, Osada M, Fomenkova T, Yuriditsky E, Trink B, Sidransky D, Ratovitski E
J Biol Chem. 2003
PubMed ID: 12692135
deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes.
King KE, Ponnamperuma RM, Yamashita T, Tokino T, Lee LA, Young MF, Weinberg WC
Oncogene. 2003
PubMed ID: 12789272
The CUSP DeltaNp63alpha isoform of human p63 is downregulated by solar-simulated ultraviolet radiation.
Marchbank A, Su LJ, Walsh P, DeGregori J, Penheiter K, Grayson TB, Dellavalle RP, Lee LA
J Dermatol Sci. 2003
PubMed ID: 12788532
Inhibition of epidermal growth factor receptor signaling decreases p63 expression in head and neck squamous carcinoma cells.
Matheny KE, Barbieri CE, Sniezek JC, Arteaga CL, Pietenpol JA
Laryngoscope. 2003
PubMed ID: 12782800
Heterozygous mutation in the SAM domain of p63 underlies Rapp-Hodgkin ectodermal dysplasia.
Kantaputra PN, Hamada T, Kumchai T, McGrath JA
J Dent Res. 2003
PubMed ID: 12766194
Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130.
Ruiz S, Segrelles C, Bravo A, Santos M, Perez P, Leis H, Jorcano JL, Paramio JM
Development. 2003
PubMed ID: 12702649
DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development.
Wu G, Nomoto S, Hoque MO, Dracheva T, Osada M, Lee CC, Dong SM, Guo Z, Benoit N, Cohen Y, Rechthand P, Califano J, Moon CS, Ratovitski E, Jen J, Sidransky D, Trink B
Cancer Res. 2003
PubMed ID: 12750249
The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations.
Westfall MD, Mays DJ, Sniezek JC, Pietenpol JA
Mol Cell Biol. 2003
PubMed ID: 12640112
The relationship between p63 and p53 expression in normal and neoplastic breast tissue.
Ribeiro-Silva A, Zambelli Ramalho LN, Britto Garcia S, Zucoloto S
Arch Pathol Lab Med. 2003
PubMed ID: 12653579
P63 is expressed in basal and myoepithelial cells of human normal and tumor salivary gland tissues.
Bilal H, Handra-Luca A, Bertrand JC, Fouret PJ
J Histochem Cytochem. 2003
PubMed ID: 12533521
p63 expression in normal human epidermis and epidermal appendages and their tumors.
Tsujita-Kyutoku M, Kiuchi K, Danbara N, Yuri T, Senzaki H, Tsubura A
J Cutan Pathol. 2003
PubMed ID: 12534798
P63 mutations are not a major cause of non-syndromic split hand/foot malformation.
de Mollerat XJ, Everman DB, Morgan CT, Clarkson KB, Rogers RC, Colby RS, Aylsworth AS, Graham JM, Stevenson RE, Schwartz CE
J Med Genet. 2003
PubMed ID: 12525544
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Diagnostic utility of immunohistochemical staining for p63, a sensitive marker of prostatic basal cells.
Weinstein MH, Signoretti S, Loda M
Mod Pathol. 2002
PubMed ID: 12481011
Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains.
Ghioni P, Bolognese F, Duijf PH, Van Bokhoven H, Mantovani R, Guerrini L
Mol Cell Biol. 2002
PubMed ID: 12446784
A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism.
Serber Z, Lai HC, Yang A, Ou HD, Sigal MS, Kelly AE, Darimont BD, Duijf PH, Van Bokhoven H, McKeon F, Dötsch V
Mol Cell Biol. 2002
PubMed ID: 12446779
SSRP1 functions as a co-activator of the transcriptional activator p63.
Zeng SX, Dai MS, Keller DM, Lu H
EMBO J. 2002
PubMed ID: 12374749
P63 gene mutations and human developmental syndromes.
Brunner HG, Hamel BC, Bokhoven Hv H
Am J Med Genet. 2002
PubMed ID: 12357472
Abnormal re-epithelialization and lung remodeling in idiopathic pulmonary fibrosis: the role of deltaN-p63.
Chilosi M, Poletti V, Murer B, Lestani M, Cancellieri A, Montagna L, Piccoli P, Cangi G, Semenzato G, Doglioni C
Lab Invest. 2002
PubMed ID: 12379768
p63 in laryngeal squamous cell carcinoma: evidence for a role of TA-p63 down-regulation in tumorigenesis and lack of prognostic implications of p63 immunoreactivity.
Pruneri G, Pignataro L, Manzotti M, Carboni N, Ronchetti D, Neri A, Cesana BM, Viale G
Lab Invest. 2002
PubMed ID: 12379767
Loss of p63 expression is associated with tumor progression in bladder cancer.
Urist MJ, Di Como CJ, Lu ML, Charytonowicz E, Verbel D, Crum CP, Ince TA, McKeon FD, Cordon-Cardo C
Am J Pathol. 2002
PubMed ID: 12368193
p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract.
Ince TA, Cviko AP, Quade BJ, Yang A, McKeon FD, Mutter GL, Crum CP
Am J Pathol. 2002
PubMed ID: 12368184
p63 expression in normal skin and usual cutaneous carcinomas.
Reis-Filho JS, Torio B, Albergaria A, Schmitt FC
J Cutan Pathol. 2002
PubMed ID: 12358808
Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.
Kim EJ, Park JS, Um SJ
J Biol Chem. 2002
PubMed ID: 11925430
Analysis of the p63 gene in classical EEC syndrome, related syndromes, and non-syndromic orofacial clefts.
Barrow LL, van Bokhoven H, Daack-Hirsch S, Andersen T, van Beersum SE, Gorlin R, Murray JC
J Med Genet. 2002
PubMed ID: 12161593
Splitting p63.
van Bokhoven H, Brunner HG
Am J Hum Genet. 2002
PubMed ID: 12037717
CUSP/p63 expression in basal cell carcinoma.
Dellavalle RP, Walsh P, Marchbank A, Grayson TE, Su LJ, Parker ER, DeGregori J, Penheiter K, Aszterbaum M, Epstein EH, Lee LA
Exp Dermatol. 2002
PubMed ID: 12102658
Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.
Strano S, Fontemaggi G, Costanzo A, Rizzo MG, Monti O, Baccarini A, Del Sal G, Levrero M, Sacchi A, Oren M, Blandino G
J Biol Chem. 2002
PubMed ID: 11893750
DeltaNp63 induces beta-catenin nuclear accumulation and signaling.
Patturajan M, Nomoto S, Sommer M, Fomenkov A, Hibi K, Zangen R, Poliak N, Califano J, Trink B, Ratovitski E, Sidransky D
Cancer Cell. 2002
PubMed ID: 12086851
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage.
Flores ER, Tsai KY, Crowley D, Sengupta S, Yang A, McKeon F, Jacks T
Nature. 2002
PubMed ID: 11932750
Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63.
Duijf PH, Vanmolkot KR, Propping P, Friedl W, Krieger E, McKeon F, Dötsch V, Brunner HG, van Bokhoven H
Hum Mol Genet. 2002
PubMed ID: 11929852
Mutations in the p53 homolog p63: allele-specific developmental syndromes in humans.
van Bokhoven H, McKeon F
Trends Mol Med. 2002
PubMed ID: 11879774
Differential protein expression, DNA binding and interaction with SV40 large tumour antigen implicate the p63-family of proteins in replicative senescence.
Djelloul S, Tarunina M, Barnouin K, Mackay A, Jat PS
Oncogene. 2002
PubMed ID: 11850815
Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis.
Choi HR, Batsakis JG, Zhan F, Sturgis E, Luna MA, El-Naggar AK
Hum Pathol. 2002
PubMed ID: 11957139
Conditional inactivation of p63 by Cre-mediated excision.
Mills AA, Qi Y, Bradley A
Genesis. 2002
PubMed ID: 11857801
p63 expression profiles in human normal and tumor tissues.
Di Como CJ, Urist MJ, Babayan I, Drobnjak M, Hedvat CV, Teruya-Feldstein J, Pohar K, Hoos A, Cordon-Cardo C
Clin Cancer Res. 2002
PubMed ID: 11839669
The p53 family member genes are involved in the Notch signal pathway.
Sasaki Y, Ishida S, Morimoto I, Yamashita T, Kojima T, Kihara C, Tanaka T, Imai K, Nakamura Y, Tokino T
J Biol Chem. 2002
PubMed ID: 11641404
p63 expression in normal, hyperplastic and malignant breast tissues.
Wang X, Mori I, Tang W, Nakamura M, Nakamura Y, Sato M, Sakurai T, Kakudo K
Breast Cancer. 2002
PubMed ID: 12185332
p63.
Little NA, Jochemsen AG
Int J Biochem Cell Biol. 2002
PubMed ID: 11733180
p53, p63 and p73--solos, alliances and feuds among family members.
Moll UM, Erster S, Zaika A
Biochim Biophys Acta. 2001
PubMed ID: 11825686
Split-hand/split-foot malformation with paternal mutation in the p63 gene.
Witters I, Van Bokhoven H, Goossens A, Van Assche FA, Fryns JP
Prenat Diagn. 2001
PubMed ID: 11787035
The p53 functional circuit.
Jin S, Levine AJ
J Cell Sci. 2001
PubMed ID: 11739646
Fibroblast growth factor receptor 2 (Fgfr2) plays an important role in eyelid and skin formation and patterning.
Li C, Guo H, Xu X, Weinberg W, Deng CX
Dev Dyn. 2001
PubMed ID: 11747081
Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders.
Glickman JN, Yang A, Shahsafaei A, McKeon F, Odze RD
Hum Pathol. 2001
PubMed ID: 11727253
High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.
Klein C, Georges G, Künkele KP, Huber R, Engh RA, Hansen S
J Biol Chem. 2001
PubMed ID: 11477076
CUSP/p63 expression in rat and human tissues.
Dellavalle RP, Egbert TB, Marchbank A, Su LJ, Lee LA, Walsh P
J Dermatol Sci. 2001
PubMed ID: 11532371
p63 expression is associated with p53 loss in oral-esophageal epithelia of p53-deficient mice.
Suliman Y, Opitz OG, Avadhani A, Burns TC, El-Deiry W, Wong DT, Rustgi AK
Cancer Res. 2001
PubMed ID: 11522642
p63 Gene mutations in eec syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation.
van Bokhoven H, Hamel BC, Bamshad M, Sangiorgi E, Gurrieri F, Duijf PH, Vanmolkot KR, van Beusekom E, van Beersum SE, Celli J, Merkx GF, Tenconi R, Fryns JP, Verloes A, Newbury-Ecob RA, Raas-Rotschild A, Majewski F, Beemer FA, Janecke A, Chitayat D, Crisponi G, Kayserili H, Yates JR, Neri G, Brunner HG
Am J Hum Genet. 2001
PubMed ID: 11462173
TP63 gene mutation in ADULT syndrome.
Amiel J, Bougeard G, Francannet C, Raclin V, Munnich A, Lyonnet S, Frebourg T
Eur J Hum Genet. 2001
PubMed ID: 11528512
Identification and tissue distribution of novel KET/p63 splice variants.
Bamberger C, Schmale H
FEBS Lett. 2001
PubMed ID: 11470269
Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51.
Senoo M, Tsuchiya I, Matsumura Y, Mori T, Saito Y, Kato H, Okamoto T, Habu S
Br J Cancer. 2001
PubMed ID: 11336476
Physical interaction with Yes-associated protein enhances p73 transcriptional activity.
Strano S, Munarriz E, Rossi M, Castagnoli L, Shaul Y, Sacchi A, Oren M, Sudol M, Cesareni G, Blandino G
J Biol Chem. 2001
PubMed ID: 11278685
p63 identifies keratinocyte stem cells.
Pellegrini G, Dellambra E, Golisano O, Martinelli E, Fantozzi I, Bondanza S, Ponzin D, McKeon F, De Luca M
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11248048
A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain.
Gaiddon C, Lokshin M, Ahn J, Zhang T, Prives C
Mol Cell Biol. 2001
PubMed ID: 11238924
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
p53CP is p51/p63, the third member of the p53 gene family: partial purification and characterization.
Tan M, Bian J, Guan K, Sun Y
Carcinogenesis. 2001
PubMed ID: 11181451
NBP is the p53 homolog p63.
Zeng X, Zhu Y, Lu H
Carcinogenesis. 2001
PubMed ID: 11181441
Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63.
McGrath JA, Duijf PH, Doetsch V, Irvine AD, de Waal R, Vanmolkot KR, Wessagowit V, Kelly A, Atherton DJ, Griffiths WA, Orlow SJ, van Haeringen A, Ausems MG, Yang A, McKeon F, Bamshad MA, Brunner HG, Hamel BC, van Bokhoven H
Hum Mol Genet. 2001
PubMed ID: 11159940
Cloning and expression of the chick p63 gene.
Yasue A, Tao H, Nohno T, Moriyama K, Noji S, Ohuchi H
Mech Dev. 2001
PubMed ID: 11118893
p63 is a prostate basal cell marker and is required for prostate development.
Signoretti S, Waltregny D, Dilks J, Isaac B, Lin D, Garraway L, Yang A, Montironi R, McKeon F, Loda M
Am J Pathol. 2000
PubMed ID: 11106548
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27.
Ianakiev P, Kilpatrick MW, Toudjarska I, Basel D, Beighton P, Tsipouras P
Am J Hum Genet. 2000
PubMed ID: 10839977
AIS is an oncogene amplified in squamous cell carcinoma.
Hibi K, Trink B, Patturajan M, Westra WH, Caballero OL, Hill DE, Ratovitski EA, Jen J, Sidransky D
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10805802
Regulation and function of the p53-related proteins: same family, different rules.
Lohrum MA, Vousden KH
Trends Cell Biol. 2000
PubMed ID: 10754563
Physical interaction between Wilms tumor 1 and p73 proteins modulates their functions.
Scharnhorst V, Dekker P, van der Eb AJ, Jochemsen AG
J Biol Chem. 2000
PubMed ID: 10744705
Expression of the p53 homologue p63alpha and deltaNp63alpha in normal and neoplastic cells.
Hall PA, Campbell SJ, O'neill M, Royston DJ, Nylander K, Carey FA, Kernohan NM
Carcinogenesis. 2000
PubMed ID: 10657951
Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome.
Celli J, Duijf P, Hamel BC, Bamshad M, Kramer B, Smits AP, Newbury-Ecob R, Hennekam RC, Van Buggenhout G, van Haeringen A, Woods CG, van Essen AJ, de Waal R, Vriend G, Haber DA, Yang A, McKeon F, Brunner HG, van Bokhoven H
Cell. 1999
PubMed ID: 10535733
Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers.
Hagiwara K, McMenamin MG, Miura K, Harris CC
Cancer Res. 1999
PubMed ID: 10485447
Characterization of an autoantigen associated with chronic ulcerative stomatitis: the CUSP autoantigen is a member of the p53 family.
Lee LA, Walsh P, Prater CA, Su LJ, Marchbank A, Egbert TB, Dellavalle RP, Targoff IN, Kaufman KM, Chorzelski TP, Jablonska S
J Invest Dermatol. 1999
PubMed ID: 10469295
p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53.
Davison TS, Vagner C, Kaghad M, Ayed A, Caput D, Arrowsmith CH
J Biol Chem. 1999
PubMed ID: 10373484
Detection of polyadenylation signals in human DNA sequences.
Tabaska JE, Zhang MQ
Gene. 1999
PubMed ID: 10231571
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development.
Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson RT, Tabin C, Sharpe A, Caput D, Crum C, McKeon F
Nature. 1999
PubMed ID: 10227294
p63 is a p53 homologue required for limb and epidermal morphogenesis.
Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A
Nature. 1999
PubMed ID: 10227293
The emerging p53 gene family.
Kaelin WG
J Natl Cancer Inst. 1999
PubMed ID: 10203277
Mutation and expression of the p51 gene in human lung cancer.
Tani M, Shimizu K, Kawahara C, Kohno T, Ishimoto O, Ikawa S, Yokota J
Neoplasia. 1999
PubMed ID: 10935472
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
A novel direct interaction of endoplasmic reticulum with microtubules.
Klopfenstein DR, Kappeler F, Hauri HP
EMBO J. 1998
PubMed ID: 9799226
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.
Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dötsch V, Andrews NC, Caput D, McKeon F
Mol Cell. 1998
PubMed ID: 9774969
A second p53-related protein, p73L, with high homology to p73.
Senoo M, Seki N, Ohira M, Sugano S, Watanabe M, Inuzuka S, Okamoto T, Tachibana M, Tanaka T, Shinkai Y, Kato H
Biochem Biophys Res Commun. 1998
PubMed ID: 9703973
Cloning and functional analysis of human p51, which structurally and functionally resembles p53.
Osada M, Ohba M, Kawahara C, Ishioka C, Kanamaru R, Katoh I, Ikawa Y, Nimura Y, Nakagawara A, Obinata M, Ikawa S
Nat Med. 1998
PubMed ID: 9662378
A new human p53 homologue.
Trink B, Okami K, Wu L, Sriuranpong V, Jen J, Sidransky D
Nat Med. 1998
PubMed ID: 9662346
Non-p53 p53RE binding protein, a human transcription factor functionally analogous to P53.
Zeng X, Levine AJ, Lu H
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9618472
p53CP, a putative p53 competing protein that specifically binds to the consensus p53 DNA binding sites: a third member of the p53 family?
Bian J, Sun Y
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9405685
A novel protein with strong homology to the tumor suppressor p53.
Schmale H, Bamberger C
Oncogene. 1997
PubMed ID: 9315105
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking.
Robinson A, Gibbins J, Rodríguez-Liñares B, Finan PM, Wilson L, Kellie S, Findell P, Watson SP
Blood. 1996
PubMed ID: 8695800
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	Human	Mouse	Rat
Entrez Gene	8626	22061	246334
EnsEMBL Gene(s)	ENSG00000073282	ENSMUSG00000022510	ENSRNOG00000001924
Unigene	Hs.137569	Mm.20894	Rn.42907
Homologene	TP63	Trp63	Tp63
OMIM	603273	N/A	N/A
GeneCards	TP63	N/A	N/A
Beta Cell Genomics	DT.100767943 DT.100767944 DT.113716 DT.75166481 DT.92433678 DT.95374522 DT.95374523	DT.101231366 DT.40153044 DT.483864 DT.87056400 DT.91300380 DT.91573320 DT.94138923 DT.97343678	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	8626	22061	246334

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Interactor	Interactor	Sources	Classification	Pubmed IDs
TP63	HNRNPR	IntAct	empirical	20085233
TP63	YAP1	MINT	empirical	11278685
TP63	SYNCRIP	IntAct	empirical	20085233
TP63	CARM1	IntAct	empirical	20085233
TP63	CENPE	IntAct	empirical	20085233
TP63	MYL12A	IntAct	empirical	20085233
TP63	CCT8	IntAct	empirical	20085233
TP63	COPS6	IntAct	empirical	21988832
TP63	CPSF6	IntAct	empirical	20085233
TP63	DAXX	HPRD	empirical	12954772
TP63	ZNF676	IntAct	empirical	20085233
TP63	DHX9	IntAct	empirical	20085233
TP63	NQO1	IntAct	empirical	21042282
TP63	EEF1A1	IntAct	empirical	20085233
TP63	A2M	IntAct	empirical	20085233
TP63	EP300	HPRD	empirical	15965232
TP63	FASN	IntAct	empirical	20085233
TP63	HNRNPA3	IntAct	empirical	20085233
TP63	FLNC	IntAct	empirical	20085233
TP63	PPP1R13B	HPRD, MINT	empirical	14729977
TP63	SLC35A3	IntAct	empirical	21988832
TP63	RPL13A	IntAct	empirical	20085233
TP63	FUS	IntAct	empirical	20085233
TP63	NIPSNAP3A	IntAct	empirical	21988832
TP63	UPF2	IntAct	empirical	20085233
TP63	SACS	IntAct	empirical	20085233
TP63	GCGR	IntAct	empirical	21988832
TP63	GOLGA4	IntAct	empirical	20085233
TP63	KRT6C	IntAct	empirical	20085233
TP63	GRB2	HPRD	empirical	8695800
TP63	HIPK2	HPRD	empirical	11925430
TP63	HIST1H1D	IntAct	empirical	20085233
TP63	HNRNPAB	HPRD, IntAct	empirical	12692135 20085233
TP63	HNRNPK	IntAct	empirical	20085233
TP63	HNRNPL	IntAct	empirical	20085233
TP63	HP	IntAct	empirical	21988832
TP63	HPX	IntAct	empirical	21988832
TP63	HSPA5	IntAct	empirical	20085233
TP63	HSP90AB1	IntAct	empirical	20085233
TP63	HNRNPCL1	IntAct	empirical	20085233
TP63	ITIH4	IntAct	empirical	21988832
TP63	KRT5	IntAct	empirical	20085233
TP63	RPSA	IntAct	empirical	20085233
TP63	SMAD2	IntAct	empirical	19345189 21741598
TP63	SMAD3	IntAct	empirical	19345189
TP63	MAP1A	IntAct	empirical	20085233
TP63	NONO	IntAct	empirical	20085233
TP63	ATP5A1	IntAct	empirical	20085233
TP63	ORM1	IntAct	empirical	21988832
TP63	PIN1	IntAct	empirical	21741598
TP63	PLS3	IntAct	empirical	20085233
TP63	S1PR5	IntAct	empirical	20085233
TP63	PINX1	IntAct	empirical	21988832
TP63	UACA	IntAct	empirical	20085233
TP63	PPP2R5A	HPRD	empirical	12086851
TP63	PSMD2	IntAct	empirical	20085233
TP63	ZBTB4	IntAct	empirical	20085233
TP63	RPL3	IntAct	empirical	20085233
TP63	RPL12	IntAct	empirical	20085233
TP63	RPL24	IntAct	empirical	20085233
TP63	RPLP0	IntAct	empirical	20085233
TP63	SAFB	IntAct	empirical	20085233
TP63	SNRPA	IntAct	empirical	20085233
TP63	TP53	HPRD, IntAct, BioGRID	empirical	11238924 19345189 21741598 20211142
TP63	TP73	HPRD, BioGRID	empirical	11238924 10373484 20211142
TP63	VCP	IntAct	empirical	20085233
TP63	WT1	HPRD	empirical	10744705
TP63	CAD	IntAct	empirical	20085233
TP63	BAG6	IntAct	empirical	21988832
TP63	TUBA1C	IntAct	empirical	20085233
TP63	TP63	HPRD, IntAct	empirical	10373484 20085233 21335238
TP63	CCNC	IntAct	empirical	21988832
TP63	SEC24C	IntAct	empirical	20085233