Home RUNX1T1
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(Human) GRCh37 - chr8:92967195..93115514 (148.32 kb) View in Genome Browser
(Mouse) NCBIM37 - chr4:13670449..13820796 (150.35 kb) View in Genome Browser
(Rat) RGSC3.4 - chr5:28230322..28338441 (108.12 kb) View in Genome Browser
HaemAtlas Expression Table for RUNX1T1:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
| no data | no data | |||||||||||
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for RUNX1T1:The RUNX1T1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| RUNX1T1 | ATN1 | HPRD, MINT, IntAct, BioGRID | empirical | 16713569 10973986 |
| RUNX1T1 | ZNF652 | HPRD, IntAct | empirical | 16966434 |
| RUNX1T1 | SIN3A | HPRD, BioGRID | empirical | 11150306 16227606 15333839 |
| RUNX1T1 | GFI1 | HPRD, BioGRID | empirical | 12874834 |
| RUNX1T1 | HDAC1 | HPRD, BioGRID | empirical | 15333839 11533236 9819405 17389244 |
| RUNX1T1 | HDAC2 | BioGRID | empirical | 11533236 |
| RUNX1T1 | HSP90AA1 | HPRD | empirical | 10076566 |
| RUNX1T1 | ID1 | HPRD, IntAct | empirical | 11591653 |
| RUNX1T1 | ID3 | HPRD, IntAct | empirical | 11591653 |
| RUNX1T1 | ID4 | BioGRID | empirical | 20211142 |
| RUNX1T1 | KPNA1 | HPRD, BioGRID | empirical | 10951564 |
| RUNX1T1 | KPNB1 | HPRD, BioGRID | empirical | 10951564 |
| RUNX1T1 | ATOH1 | BioGRID | empirical | 20211142 |
| RUNX1T1 | NEUROD1 | BioGRID | empirical | 20211142 |
| RUNX1T1 | NEUROG1 | BioGRID | empirical | 20211142 |
| RUNX1T1 | ABI3 | HPRD, MINT, IntAct, BioGRID | empirical | 16189514 |
| RUNX1T1 | TRIM33 | IntAct, BioGRID | empirical | 20603019 |
| RUNX1T1 | TAF9B | HPRD, MINT, IntAct, BioGRID | empirical | 16189514 |
| RUNX1T1 | WBP11 | HPRD, MINT, IntAct, BioGRID | empirical | 16189514 |
| RUNX1T1 | NECAB2 | HPRD, MINT, BioGRID | empirical | 16189514 |
| RUNX1T1 | OTUD4 | IntAct, BioGRID | empirical | 17353931 |
| RUNX1T1 | PRKAR2A | HPRD, BioGRID | empirical | 11593431 |
| RUNX1T1 | HDAC8 | HPRD, BioGRID | empirical | 11533236 |
| RUNX1T1 | UBQLN4 | HPRD, MINT, IntAct | empirical | 16713569 |
| RUNX1T1 | PSMD11 | IntAct | empirical | 17353931 |
| RUNX1T1 | NEUROD4 | BioGRID | empirical | 20211142 |
| RUNX1T1 | PRDM14 | BioGRID | empirical | 20211142 |
| RUNX1T1 | CEP170P1 | MINT, IntAct, BioGRID | empirical | 16189514 |
| RUNX1T1 | TAL2 | BioGRID | empirical | 20211142 |
| RUNX1T1 | TCF4 | HPRD | empirical | 15333839 |
| RUNX1T1 | TCF3 | HPRD, BioGRID | empirical | 15333839 |
| RUNX1T1 | TCF12 | BioGRID | empirical | 15333839 |
| RUNX1T1 | UBC | BioGRID | empirical | 18073335 |
| RUNX1T1 | UBE2E2 | BioGRID | empirical | 18073335 |
| RUNX1T1 | VDR | BioGRID | empirical | 12460926 |
| RUNX1T1 | ZBTB16 | HPRD, BioGRID | empirical | 10688654 11090081 |
| RUNX1T1 | C19orf57 | HPRD, IntAct, BioGRID | empirical | 16189514 |
| RUNX1T1 | PCBD2 | BioGRID | empirical | 20211142 |
| RUNX1T1 | RUNX1 | BioGRID | empirical | 10882117 |
| RUNX1T1 | RUNX1T1 | HPRD, IntAct, BioGRID | empirical | 11113190 16616331 |
| RUNX1T1 | CBFA2T3 | HPRD, BioGRID | empirical | 14703694 12242670 |
| RUNX1T1 | HDAC3 | HPRD, BioGRID | empirical | 15333839 11533236 |
| RUNX1T1 | CBFA2T2 | BioGRID | empirical | 16189514 14703694 12242670 15333839 |
| RUNX1T1 | NCOR1 | HPRD, BioGRID | empirical | 15109542 11113190 11533236 16227606 15333839 10882117 9819405 |
| RUNX1T1 | NCOR2 | HPRD | empirical | 11113190 |
| RUNX1T1 | THRAP3 | IntAct, BioGRID | empirical | 17353931 |
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Publications: 156
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Submicroscopic deletion of RUNX1T1 gene confirmed by high-resolution microarray in acute myeloid leukemia with RUNX1/RUNX1T1 rearrangement.
Yang JJ, Oh SH, Cho SY, Suh JT, Lee HJ, Lee WI, Lee J, Baek SK, Yoon HJ, Cho EH, Park TS
Acta Haematol. 2012
PubMed ID: 22025082
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Mutational analysis of RUNX1T1 gene in acute leukemias, breast and lung carcinomas.
Kim YR, Kim MS, Lee SH, Yoo NJ
Leuk Res. 2011
PubMed ID: 21571369
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The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.
Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, Jiang Y, Cole PA, Zhang J, Melnick A, Roeder RG, Nimer SD
Science. 2011
PubMed ID: 21764752
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Aberrant TGFβ/SMAD4 signaling contributes to epigenetic silencing of a putative tumor suppressor, RunX1T1 in ovarian cancer.
Yeh KT, Chen TH, Yang HW, Chou JL, Chen LY, Yeh CM, Chen YH, Lin RI, Su HY, Chen GC, Deatherage DE, Huang YW, Yan PS, Lin HJ, Nephew KP, Huang TH, Lai HC, Chan MW
Epigenetics. 2011
PubMed ID: 21540640
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RUNX1T1: a novel predictor of liver metastasis in primary pancreatic endocrine neoplasms.
Nasir A, Helm J, Turner L, Chen DT, Strosberg J, Hafez N, Henderson-Jackson EB, Hodul P, Bui MM, Nasir NA, Hakam A, Malafa MP, Yeatman TJ, Coppola D, Kvols LK
Pancreas. 2011
PubMed ID: 21499216
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AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein.
Steffen B, Knop M, Bergholz U, Vakhrusheva O, Rode M, Köhler G, Henrichs MP, Bulk E, Hehn S, Stehling M, Dugas M, Bäumer N, Tschanter P, Brandts C, Koschmieder S, Berdel WE, Serve H, Stocking C, Müller-Tidow C
Blood. 2011
PubMed ID: 21245488
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N-Ras(G12D) induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene.
Chou FS, Wunderlich M, Griesinger A, Mulloy JC
Blood. 2011
PubMed ID: 21200020
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Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.
Campbell GR, Baudhuin A, Vranizan K, Ngai J
Mol Cell Neurosci. 2011
PubMed ID: 21194568
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model.
Sinenko SA, Hung T, Moroz T, Tran QM, Sidhu S, Cheney MD, Speck NA, Banerjee U
Blood. 2010
PubMed ID: 20688956
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Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity.
Corpora T, Roudaia L, Oo ZM, Chen W, Manuylova E, Cai X, Chen MJ, Cierpicki T, Speck NA, Bushweller JH
J Mol Biol. 2010
PubMed ID: 20708017
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Dimer-tetramer transition controls RUNX1/ETO leukemogenic activity.
Wichmann C, Becker Y, Chen-Wichmann L, Vogel V, Vojtkova A, Herglotz J, Moore S, Koch J, Lausen J, Mäntele W, Gohlke H, Grez M
Blood. 2010
PubMed ID: 20430957
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TIF1gamma controls erythroid cell fate by regulating transcription elongation.
Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI
Cell. 2010
PubMed ID: 20603019
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NHR4 domain mutations of ETO are probably very infrequent in AML1-ETO positive myeloid leukemia cells.
Hackanson B, Abdelkarim M, Jansen JH, Lübbert M
Leukemia. 2010
PubMed ID: 20090777
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An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
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The leukemia associated ETO nuclear repressor gene is regulated by the GATA-1 transcription factor in erythroid/megakaryocytic cells.
Ajore R, Dhanda RS, Gullberg U, Olsson I
BMC Mol Biol. 2010
PubMed ID: 20487545
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A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
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Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers.
Coulpier F, Le Crom S, Maro GS, Manent J, Giovannini M, Maciorowski Z, Fischer A, Gessler M, Charnay P, Topilko P
Glia. 2009
PubMed ID: 19243017
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AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2.
Jiao B, Wu CF, Liang Y, Chen HM, Xiong SM, Chen B, Shi JY, Wang YY, Wang JH, Chen Y, Li JM, Gu LJ, Tang JY, Shen ZX, Gu BW, Zhao WL, Chen Z, Chen SJ
Leukemia. 2009
PubMed ID: 19458628
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Regional expression of MTG genes in the developing mouse central nervous system.
Alishahi A, Koyano-Nakagawa N, Nakagawa Y
Dev Dyn. 2009
PubMed ID: 19618476
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A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO.
Osman D, Gobert V, Ponthan F, Heidenreich O, Haenlin M, Waltzer L
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19581587
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RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress.
Wolyniec K, Wotton S, Kilbey A, Jenkins A, Terry A, Peters G, Stocking C, Cameron E, Neil JC
Oncogene. 2009
PubMed ID: 19448675
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Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Multivalent binding of the ETO corepressor to E proteins facilitates dual repression controls targeting chromatin and the basal transcription machinery.
Guo C, Hu Q, Yan C, Zhang J
Mol Cell Biol. 2009
PubMed ID: 19289505
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Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.
Park S, Chen W, Cierpicki T, Tonelli M, Cai X, Speck NA, Bushweller JH
Blood. 2009
PubMed ID: 19204326
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CBFbeta is critical for AML1-ETO and TEL-AML1 activity.
Roudaia L, Cheney MD, Manuylova E, Chen W, Morrow M, Park S, Lee CT, Kaur P, Williams O, Bushweller JH, Speck NA
Blood. 2009
PubMed ID: 19179469
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RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis.
Yan M, Ahn EY, Hiebert SW, Zhang DE
Blood. 2009
PubMed ID: 19036704
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Duplication and triplication of der(21)t(8;21)(q22;q22) in acute myeloid leukemia.
Mikulasovich M, LeBlanc A, Scalise A, Manwani D, Keyzner A, Najfeld V
Cancer Genet Cytogenet. 2009
PubMed ID: 19100510
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Transient depletion of RUNX1/RUNX1T1 by RNA interference delays tumour formation in vivo.
Martinez Soria N, Tussiwand R, Ziegler P, Manz MG, Heidenreich O
Leukemia. 2009
PubMed ID: 18548094
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The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes.
Bakshi R, Zaidi SK, Pande S, Hassan MQ, Young DW, Montecino M, Lian JB, van Wijnen AJ, Stein JL, Stein GS
J Cell Sci. 2008
PubMed ID: 19001502
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Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis.
Ahn EY, Yan M, Malakhova OA, Lo MC, Boyapati A, Ommen HB, Hines R, Hokland P, Zhang DE
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18952841
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AML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets.
Gardini A, Cesaroni M, Luzi L, Okumura AJ, Biggs JR, Minardi SP, Venturini E, Zhang DE, Pelicci PG, Alcalay M
PLoS Genet. 2008
PubMed ID: 19043539
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AML1/ETO-induced survivin expression inhibits transcriptional regulation of myeloid differentiation.
Balkhi MY, Christopeit M, Chen Y, Geletu M, Behre G
Exp Hematol. 2008
PubMed ID: 18687517
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Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
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Transcriptional repression by leukaemia-associated ETO family members can be independent of oligomerization and coexpressed hSIN3B and N-CoR.
Olsson A, Olsson I, Dhanda RS
Biochim Biophys Acta. 2008
PubMed ID: 18586123
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Roles of p15Ink4b and p16Ink4a in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemia.
Ko RM, Kim HG, Wolff L, Klug CA
Leuk Res. 2008
PubMed ID: 18037485
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AML1-ETO interacts with Sp1 and antagonizes Sp1 transactivity through RUNT domain.
Wei H, Liu X, Xiong X, Wang Y, Rao Q, Wang M, Wang J
FEBS Lett. 2008
PubMed ID: 18519037
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Repositioning of ETO gene in cells treated with VP-16, an inhibitor of DNA-topoisomerase II.
Rubtsov MA, Terekhov SM, Razin SV, Iarovaia OV
J Cell Biochem. 2008
PubMed ID: 18183572
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ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes.
Salat D, Liefke R, Wiedenmann J, Borggrefe T, Oswald F
Mol Cell Biol. 2008
PubMed ID: 18332109
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Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha.
Krämer OH, Müller S, Buchwald M, Reichardt S, Heinzel T
FASEB J. 2008
PubMed ID: 18073335
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Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.
Dayyani F, Wang J, Yeh JR, Ahn EY, Tobey E, Zhang DE, Bernstein ID, Peterson RT, Sweetser DA
Blood. 2008
PubMed ID: 18258796
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GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
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Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription.
Moore AC, Amann JM, Williams CS, Tahinci E, Farmer TE, Martinez JA, Yang G, Luce KS, Lee E, Hiebert SW
Mol Cell Biol. 2008
PubMed ID: 18039847
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Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity.
Lu Y, Peng ZG, Yuan TT, Yin QQ, Xia L, Chen GQ
Leukemia. 2008
PubMed ID: 17989718
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The human SIN3B corepressor forms a nucleolar complex with leukemia-associated ETO homologues.
Dhanda RS, Lindberg SR, Olsson I
BMC Mol Biol. 2008
PubMed ID: 18205948
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AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression.
Yeh JR, Munson KM, Chao YL, Peterson QP, Macrae CA, Peterson RT
Development. 2008
PubMed ID: 18156164
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Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction.
Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI
Gene Expr Patterns. 2008
PubMed ID: 18023262
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Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein.
Fazi F, Racanicchi S, Zardo G, Starnes LM, Mancini M, Travaglini L, Diverio D, Ammatuna E, Cimino G, Lo-Coco F, Grignani F, Nervi C
Cancer Cell. 2007
PubMed ID: 17996649
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Immunophenotypic profile predictive of KIT activating mutations in AML1-ETO leukemia.
De J, Zanjani R, Hibbard M, Davis BH
Am J Clin Pathol. 2007
PubMed ID: 17875504
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AML1-ETO meets JAK2: clinical evidence for the two hit model of leukemogenesis from a myeloproliferative syndrome progressing to acute myeloid leukemia.
Schneider F, Bohlander SK, Schneider S, Papadaki C, Kakadyia P, Dufour A, Vempati S, Unterhalt M, Feuring-Buske M, Buske C, Braess J, Wandt H, Hiddemann W, Spiekermann K
Leukemia. 2007
PubMed ID: 17625612
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Leukemogenic AML1-ETO fusion protein increases carcinogen-DNA adduct formation with upregulated expression of cytochrome P450-1A1 gene.
Xu M, Li D, Lu Y, Chen GQ
Exp Hematol. 2007
PubMed ID: 17560011
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A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription.
Wei Y, Liu S, Lausen J, Woodrell C, Cho S, Biris N, Kobayashi N, Wei Y, Yokoyama S, Werner MH
Nat Struct Mol Biol. 2007
PubMed ID: 17572682
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Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.
Liu Y, Chen W, Gaudet J, Cheney MD, Roudaia L, Cierpicki T, Klet RC, Hartman K, Laue TM, Speck NA, Bushweller JH
Cancer Cell. 2007
PubMed ID: 17560331
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Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cells.
Liu S, Klisovic RB, Vukosavljevic T, Yu J, Paschka P, Huynh L, Pang J, Neviani P, Liu Z, Blum W, Chan KK, Perrotti D, Marcucci G
J Pharmacol Exp Ther. 2007
PubMed ID: 17389244
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The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.
Peterson LF, Yan M, Zhang DE
Blood. 2007
PubMed ID: 17284535
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Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia.
Fazi F, Zardo G, Gelmetti V, Travaglini L, Ciolfi A, Di Croce L, Rosa A, Bozzoni I, Grignani F, Lo-Coco F, Pelicci PG, Nervi C
Blood. 2007
PubMed ID: 17244680
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Aberrant transcriptional regulation of the MLL fusion partner EEN by AML1-ETO and its implication in leukemogenesis.
Ma LH, Liu H, Xiong H, Chen B, Zhang XW, Wang YY, Le HY, Huang QH, Zhang QH, Li BL, Chen Z, Chen SJ
Blood. 2007
PubMed ID: 16990610
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[Expression of AML1/ETO9a isoform in acute myeloid leukemia-M2 subtype]
Miao YQ, Chen ZX, He J, Cen JN, Bao XJ, Qiu QC, Zhang DE, Yan M
Zhonghua Xue Ye Xue Za Zhi. 2007
PubMed ID: 17649722
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Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
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The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
Science. 2006
PubMed ID: 16959974
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siRNA-mediated AML1/MTG8 depletion affects differentiation and proliferation-associated gene expression in t(8;21)-positive cell lines and primary AML blasts.
Dunne J, Cullmann C, Ritter M, Soria NM, Drescher B, Debernardi S, Skoulakis S, Hartmann O, Krause M, Krauter J, Neubauer A, Young BD, Heidenreich O
Oncogene. 2006
PubMed ID: 16652140
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ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription.
Kumar R, Manning J, Spendlove HE, Kremmidiotis G, McKirdy R, Lee J, Millband DN, Cheney KM, Stampfer MR, Dwivedi PP, Morris HA, Callen DF
Mol Cancer Res. 2006
PubMed ID: 16966434
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Identification of candidate maternal-effect genes through comparison of multiple microarray data sets.
Mager J, Schultz RM, Brunk BP, Bartolomei MS
Mamm Genome. 2006
PubMed ID: 16964442
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Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: the role in AML 1-ETO-induced growth arrest in leukemic cells.
Li X, Xu YB, Wang Q, Lu Y, Zheng Y, Wang YC, Lübbert M, Zhao KW, Chen GQ
J Cell Physiol. 2006
PubMed ID: 16741927
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Comparative proteomic analysis of human leukemic cells with and without inducible expression of leukemogenic AML1-ETO protein.
Zhang L, Wang LS, Xu Y, Xia L, Chen WL, Zheng Y, Chen GQ
Chin J Physiol. 2006
PubMed ID: 17058450
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A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis.
Yan M, Kanbe E, Peterson LF, Boyapati A, Miao Y, Wang Y, Chen IM, Chen Z, Rowley JD, Willman CL, Zhang DE
Nat Med. 2006
PubMed ID: 16892037
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The acute myeloid leukemia fusion protein AML1-ETO targets E proteins via a paired amphipathic helix-like TBP-associated factor homology domain.
Plevin MJ, Zhang J, Guo C, Roeder RG, Ikura M
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16803958
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A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY
Cell. 2006
PubMed ID: 16713569
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Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening.
Li MZ, Wang JS, Jiang DJ, Xiang CX, Wang FY, Zhang KH, Williams PR, Chen ZF
Dev Biol. 2006
PubMed ID: 16516881
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The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity.
Liu Y, Cheney MD, Gaudet JJ, Chruszcz M, Lukasik SM, Sugiyama D, Lary J, Cole J, Dauter Z, Minor W, Speck NA, Bushweller JH
Cancer Cell. 2006
PubMed ID: 16616331
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BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
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DNA sequence and analysis of human chromosome 8.
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Nature. 2006
PubMed ID: 16421571
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Diagnosis and monitoring of AML1-MTG8 (ETO)-positive acute myeloid leukemia by qualitative and real-time quantitative RT-PCR.
Tobal K, Liu Yin JA
Methods Mol Med. 2006
PubMed ID: 16502583
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Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
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High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization.
Yoshikawa T, Piao Y, Zhong J, Matoba R, Carter MG, Wang Y, Goldberg I, Ko MS
Gene Expr Patterns. 2006
PubMed ID: 16325481
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Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine.
Amann JM, Chyla BJ, Ellis TC, Martinez A, Moore AC, Franklin JL, McGhee L, Meyers S, Ohm JE, Luce KS, Ouelette AJ, Washington MK, Thompson MA, King D, Gautam S, Coffey RJ, Whitehead RH, Hiebert SW
Mol Cell Biol. 2005
PubMed ID: 16227606
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Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor.
Wildonger J, Mann RS
Development. 2005
PubMed ID: 15829516
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MYND-less splice variants of AML1-MTG8 (RUNX1-CBFA2T1) are expressed in leukemia with t(8;21).
Kozu T, Fukuyama T, Yamami T, Akagi K, Kaneko Y
Genes Chromosomes Cancer. 2005
PubMed ID: 15723339
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Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia.
Liu S, Shen T, Huynh L, Klisovic MI, Rush LJ, Ford JL, Yu J, Becknell B, Li Y, Liu C, Vukosavljevic T, Whitman SP, Chang KS, Byrd JC, Perrotti D, Plass C, Marcucci G
Cancer Res. 2005
PubMed ID: 15735013
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The Leukemia-associated ETO homologues are differently expressed during hematopoietic differentiation.
Lindberg SR, Olsson A, Persson AM, Olsson I
Exp Hematol. 2005
PubMed ID: 15676213
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Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
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Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development.
Yan M, Burel SA, Peterson LF, Kanbe E, Iwasaki H, Boyapati A, Hines R, Akashi K, Zhang DE
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15569932
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The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO.
Lausen J, Cho S, Liu S, Werner MH
J Biol Chem. 2004
PubMed ID: 15377655
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ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesis.
Rochford JJ, Semple RK, Laudes M, Boyle KB, Christodoulides C, Mulligan C, Lelliott CJ, Schinner S, Hadaschik D, Mahadevan M, Sethi JK, Vidal-Puig A, O'Rahilly S
Mol Cell Biol. 2004
PubMed ID: 15509789
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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E protein silencing by the leukemogenic AML1-ETO fusion protein.
Zhang J, Kalkum M, Yamamura S, Chait BT, Roeder RG
Science. 2004
PubMed ID: 15333839
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The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells.
Martinez N, Drescher B, Riehle H, Cullmann C, Vornlocher HP, Ganser A, Heil G, Nordheim A, Krauter J, Heidenreich O
BMC Cancer. 2004
PubMed ID: 15298716
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Cloning, expression, purification and crystallization of NHR3 domain from acute myelogenous leukemia-related protein AML1-ETO.
Yang HT, Wu DH, Xue XY, Liang WX, Miao XY, Pang H, Chen SJ
Acta Biochim Biophys Sin (Shanghai). 2004
PubMed ID: 15295650
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The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT.
Takahashi S, McConnell MJ, Harigae H, Kaku M, Sasaki T, Melnick AM, Licht JD
Blood. 2004
PubMed ID: 14982881
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Dose dependent long-term in vivo remission of AML1/ETO positive acute myeloid leukemia with G-CSF.
Zomas A, Stefanoudaki-Sofianatou K, Fisfis M, Anagnostopoulos NI
Hematology. 2004
PubMed ID: 15203865
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Domains involved in ETO and human N-CoR interaction and ETO transcription repression.
Wang J, Wang M, Liu JM
Leuk Res. 2004
PubMed ID: 15109542
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
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ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein.
Chevallier N, Corcoran CM, Lennon C, Hyjek E, Chadburn A, Bardwell VJ, Licht JD, Melnick A
Blood. 2004
PubMed ID: 14551142
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
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GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
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Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins.
Lindberg SR, Olsson A, Persson AM, Olsson I
Eur J Haematol. 2003
PubMed ID: 14703694
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism.
McGhee L, Bryan J, Elliott L, Grimes HL, Kazanjian A, Davis JN, Meyers S
J Cell Biochem. 2003
PubMed ID: 12874834
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Epigenetic consequences of AML1-ETO action at the human c-FMS locus.
Follows GA, Tagoh H, Lefevre P, Hodge D, Morgan GJ, Bonifer C
EMBO J. 2003
PubMed ID: 12773394
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Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.
Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T, Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA, Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts P, Muramatsu M, Okazaki Y, Kawai J, Hayashizaki Y
Genome Res. 2003
PubMed ID: 12819125
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[Analysis of 21 children with acute non-lymphoid leukemia carrying AML1/ETO fusion gene]
Zhao W, Li ZG, Wu MY, Geng LZ, Shi HW, Zhang YH, Wu RH
Zhonghua Er Ke Za Zhi. 2003
PubMed ID: 14751048
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Cryptic chromosomal aberrations leading to an AML1/ETO rearrangement are frequently caused by small insertions.
Gamerdinger U, Teigler-Schlegel A, Pils S, Bruch J, Viehmann S, Keller M, Jauch A, Harbott J
Genes Chromosomes Cancer. 2003
PubMed ID: 12557226
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The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells.
Tonks A, Pearn L, Tonks AJ, Pearce L, Hoy T, Phillips S, Fisher J, Downing JR, Burnett AK, Darley RL
Blood. 2003
PubMed ID: 12393523
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor.
Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M
Cancer Res. 2002
PubMed ID: 12460926
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Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins.
Barseguian K, Lutterbach B, Hiebert SW, Nickerson J, Lian JB, Stein JL, van Wijnen AJ, Stein GS
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12427969
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AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency.
Schwieger M, Löhler J, Friel J, Scheller M, Horak I, Stocking C
J Exp Med. 2002
PubMed ID: 12417632
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The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies.
Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N
Oncogene. 2002
PubMed ID: 12242670
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Potential involvement of the AML1-MTG8 fusion protein in the granulocytic maturation characteristic of the t(8;21) acute myelogenous leukemia revealed by microarray analysis.
Shimada H, Ichikawa H, Ohki M
Leukemia. 2002
PubMed ID: 11986950
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Analysis of the nuclear distribution of the translocation t(8;21)-derived fusion protein AML1/ETO by confocal laser scanning microscopy.
Nagel S, Hambach L, Krauter J, Venturini L, Heidenreich O, Ganser A, Heil G
J Hematother Stem Cell Res. 2002
PubMed ID: 11983111
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Acute myeloid leukemia with t(8;21)/AML1/ETO: a distinct biological and clinical entity.
Ferrara F, Del Vecchio L
Haematologica. 2002
PubMed ID: 11869944
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Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia.
Higuchi M, O'Brien D, Kumaravelu P, Lenny N, Yeoh EJ, Downing JR
Cancer Cell. 2002
PubMed ID: 12086889
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Protein-protein interaction panel using mouse full-length cDNAs.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y
Genome Res. 2001
PubMed ID: 11591653
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ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.
Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW
Mol Cell Biol. 2001
PubMed ID: 11533236
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MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes.
Fukuyama T, Sueoka E, Sugio Y, Otsuka T, Niho Y, Akagi K, Kozu T
Oncogene. 2001
PubMed ID: 11593431
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Gene targeting reveals a crucial role for MTG8 in the gut.
Calabi F, Pannell R, Pavloska G
Mol Cell Biol. 2001
PubMed ID: 11463846
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Multiple regions of ETO cooperate in transcriptional repression.
Hildebrand D, Tiefenbach J, Heinzel T, Grez M, Maurer AB
J Biol Chem. 2001
PubMed ID: 11150306
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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Oligomerization of ETO is obligatory for corepressor interaction.
Zhang J, Hug BA, Huang EY, Chen CW, Gelmetti V, Maccarana M, Minucci S, Pelicci PG, Lazar MA
Mol Cell Biol. 2001
PubMed ID: 11113190
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AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein.
Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD
Blood. 2000
PubMed ID: 11090081
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos.
Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG
Mech Dev. 2000
PubMed ID: 11044609
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription.
Wood JD, Nucifora FC, Duan K, Zhang C, Wang J, Kim Y, Schilling G, Sacchi N, Liu JM, Ross CA
J Cell Biol. 2000
PubMed ID: 10973986
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Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse.
Buchholz F, Refaeli Y, Trumpp A, Bishop JM
EMBO Rep. 2000
PubMed ID: 11265752
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Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
-
Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8).
Odaka Y, Mally A, Elliott LT, Meyers S
Oncogene. 2000
PubMed ID: 10951564
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AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation.
Miyamoto T, Weissman IL, Akashi K
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10861016
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Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.
Minucci S, Maccarana M, Cioce M, De Luca P, Gelmetti V, Segalla S, Di Croce L, Giavara S, Matteucci C, Gobbi A, Bianchini A, Colombo E, Schiavoni I, Badaracco G, Hu X, Lazar MA, Landsberger N, Nervi C, Pelicci PG
Mol Cell. 2000
PubMed ID: 10882117
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The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein.
Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD
Mol Cell Biol. 2000
PubMed ID: 10688654
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Structure and expression pattern of a human MTG8/ETO family gene, MTGR1.
Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki M, Munakata N, Ohki M
Gene. 2000
PubMed ID: 10675041
-
ETO-2, a new member of the ETO-family of nuclear proteins.
Davis JN, Williams BJ, Herron JT, Galiano FJ, Meyers S
Oncogene. 1999
PubMed ID: 10022820
-
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
-
Association of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines.
Komori A, Sueoka E, Fujiki H, Ishii M, Kozu T
Jpn J Cancer Res. 1999
PubMed ID: 10076566
-
Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.
Gelmetti V, Zhang J, Fanelli M, Minucci S, Pelicci PG, Lazar MA
Mol Cell Biol. 1998
PubMed ID: 9819405
-
CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family.
Calabi F, Cilli V
Genomics. 1998
PubMed ID: 9790752
-
Polymorphism in the 3' untranslated region of MTG8 is associated with obesity in Pima Indian males.
Wolford JK, Bogardus C, Prochazka M
Biochem Biophys Res Commun. 1998
PubMed ID: 9618262
-
Structure and expression of the human MTG8/ETO gene.
Wolford JK, Prochazka M
Gene. 1998
PubMed ID: 9661669
-
Subcellular localization of the oncoprotein MTG8 (CDR/ETO) in neural cells.
Sacchi N, Tamanini F, Willemsen R, Denis-Donini S, Campiglio S, Hoogeveen AT
Oncogene. 1998
PubMed ID: 9632137
-
Large-scale concatenation cDNA sequencing.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA
Genome Res. 1997
PubMed ID: 9110174
-
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
-
ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease.
Erickson PF, Dessev G, Lasher RS, Philips G, Robinson M, Drabkin HA
Blood. 1996
PubMed ID: 8781439
-
A "double adaptor" method for improved shotgun library construction.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA
Anal Biochem. 1996
PubMed ID: 8619474
-
Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia.
Niwa-Kawakita M, Miyoshi H, Gotoh O, Matsushima Y, Nishimura M, Shisa H, Ohki M
Genomics. 1995
PubMed ID: 8575770
-
Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells.
Era T, Asou N, Kunisada T, Yamasaki H, Asou H, Kamada N, Nishikawa S, Yamaguchi K, Takatsuki K
Genes Chromosomes Cancer. 1995
PubMed ID: 7541640
-
Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2.
Tighe JE, Calabi F
Blood. 1994
PubMed ID: 7919324
-
The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor.
Erickson PF, Robinson M, Owens G, Drabkin HA
Cancer Res. 1994
PubMed ID: 8137293
-
Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction.
Kozu T, Miyoshi H, Shimizu K, Maseki N, Kaneko Y, Asou H, Kamada N, Ohki M
Blood. 1993
PubMed ID: 8353289
-
The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript.
Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N, Ohki M
EMBO J. 1993
PubMed ID: 8334990
-
Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells.
Nisson PE, Watkins PC, Sacchi N
Cancer Genet Cytogenet. 1992
PubMed ID: 1423235
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Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt.
Erickson P, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley J, Drabkin H
Blood. 1992
PubMed ID: 1391946
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