RUVBL1

Summary Top Help

Gene Description:

RuvB-like 1 (E. coli); RuvB-like protein 1

Synonyms:

RVB1, Pontin52, NMP238, PONTIN, Tip49a, TIH1, TIP49, Ruvbl1, 2510009G06Rik, ECP54, RUVBL1, INO80H, TIP49A

Orthologs:

Human RUVBL1 (protein-coding), Mouse Ruvbl1 (protein-coding), Rat Ruvbl1 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1 Rat: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd20	Mouse	chr6:83595701..91990027	8.39	150	1 no lod score

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm14	Rat	chr4:63276741..160891592	97.61	815

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr3:127783625..127872757 (89.13 kb) View in Genome Browser

(Mouse) NCBIM37 - chr6:88415403..88447566 (32.16 kb) View in Genome Browser

(Rat) RGSC3.4 - chr4:122556839..122591769 (34.93 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for RUVBL1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for RUVBL1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 1

Biocarta: None available

Reactome: 3

NCI-Nature Pathway Interaction Database: 3

Gene Ontology: 33

Publications from PubMed Top Help

Publications: 117

Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism.
Fedorova OA, Moiseeva TN, Nikiforov AA, Tsimokha AS, Livinskaya VA, Hodson M, Bottrill A, Evteeva IN, Ermolayeva JB, Kuznetzova IM, Turoverov KK, Eperon I, Barlev NA
Biochem Biophys Res Commun. 2011
PubMed ID: 22079093
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
Hypoxia-induced methylation of a pontin chromatin remodeling factor.
Lee JS, Kim Y, Bhin J, Shin HJ, Nam HJ, Lee SH, Yoon JB, Binda O, Gozani O, Hwang D, Baek SH
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21825155
A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis.
Taniue K, Oda T, Hayashi T, Okuno M, Akiyama T
EMBO Rep. 2011
PubMed ID: 21617703
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.
Chen L, Cai Y, Jin J, Florens L, Swanson SK, Washburn MP, Conaway JW, Conaway RC
J Biol Chem. 2011
PubMed ID: 21303910
Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
Greco TM, Yu F, Guise AJ, Cristea IM
Mol Cell Proteomics. 2011
PubMed ID: 21081666
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.
Takai H, Xie Y, de Lange T, Pavletich NP
Genes Dev. 2010
PubMed ID: 20801936
Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.
Notaridou M, Quaye L, Dafou D, Jones C, Song H, Høgdall E, Kjaer SK, Christensen L, Høgdall C, Blaakaer J, McGuire V, Wu AH, Van Den Berg DJ, Pike MC, Gentry-Maharaj A, Wozniak E, Sher T, Jacobs IJ, Tyrer J, Schildkraut JM, Moorman PG, Iversen ES, Jakubowska A, Medrek K, Lubiński J, Ness RB, Moysich KB, Lurie G, Wilkens LR, Carney ME, Wang-Gohrke S, Doherty JA, Rossing MA, Beckmann MW, Thiel FC, Ekici AB, Chen X, Beesley J, Gronwald J, Fasching PA, Chang-Claude J, Goodman MT, Chenevix-Trench G, Berchuck A, Pearce CL, Whittemore AS, Menon U, Pharoah PD, Gayther SA, Ramus SJ, The Australian Ovarian Cancer Study Group/Australian Cancer Study (Ovarian Cancer), on behalf of the Ovarian Cancer Association Consortium
Int J Cancer. 2010
PubMed ID: 20635389
Negative regulation of hypoxic responses via induced Reptin methylation.
Lee JS, Kim Y, Kim IS, Kim B, Choi HJ, Lee JM, Shin HJ, Kim JH, Kim JY, Seo SB, Lee H, Binda O, Gozani O, Semenza GL, Kim M, Kim KI, Hwang D, Baek SH
Mol Cell. 2010
PubMed ID: 20603076
Oligomeric assembly and interactions within the human RuvB-like RuvBL1 and RuvBL2 complexes.
Niewiarowski A, Bradley AS, Gor J, McKay AR, Perkins SJ, Tsaneva IR
Biochem J. 2010
PubMed ID: 20412048
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
An Oct4-centered protein interaction network in embryonic stem cells.
van den Berg DL, Snoek T, Mullin NP, Yates A, Bezstarosti K, Demmers J, Chambers I, Poot RA
Cell Stem Cell. 2010
PubMed ID: 20362541
MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.
Hayakawa T, Zhang F, Hayakawa N, Ohtani Y, Shinmyozu K, Nakayama J, Andreassen PR
J Cell Sci. 2010
PubMed ID: 20332121
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.
Izumi N, Yamashita A, Iwamatsu A, Kurata R, Nakamura H, Saari B, Hirano H, Anderson P, Ohno S
Sci Signal. 2010
PubMed ID: 20371770
[Significance and expression of S100A9 and NMP238 in cervical carcinoma tissues with different concurrent chemoradiotherapy sensitivities].
Zhu H, Zeng S, Zeng L, Wang X, Xiao Z
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010
PubMed ID: 20130364
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
Adenosine triphosphatase pontin is overexpressed in hepatocellular carcinoma and coregulated with reptin through a new posttranslational mechanism.
Haurie V, Ménard L, Nicou A, Touriol C, Metzler P, Fernandez J, Taras D, Lestienne P, Balabaud C, Bioulac-Sage P, Prats H, Zucman-Rossi J, Rosenbaum J
Hepatology. 2009
PubMed ID: 19877184
Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process.
Negishi M, Chiba T, Saraya A, Miyagi S, Iwama A
Genes Cells. 2009
PubMed ID: 19845771
Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis.
McKeegan KS, Debieux CM, Watkins NJ
Mol Cell Biol. 2009
PubMed ID: 19620283
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes.
Cloutier P, Al-Khoury R, Lavallée-Adam M, Faubert D, Jiang H, Poitras C, Bouchard A, Forget D, Blanchette M, Coulombe B
Methods. 2009
PubMed ID: 19450687
Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.
Rashid S, Pilecka I, Torun A, Olchowik M, Bielinska B, Miaczynska M
J Biol Chem. 2009
PubMed ID: 19433865
Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery.
de Planell-Saguer M, Schroeder DG, Rodicio MC, Cox GA, Mourelatos Z
Hum Mol Genet. 2009
PubMed ID: 19299493
RVB1/RVB2: running rings around molecular biology.
Jha S, Dutta A
Mol Cell. 2009
PubMed ID: 19524533
Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival.
Quaye L, Dafou D, Ramus SJ, Song H, Gentry-Maharaj A, Maharaj AG, Notaridou M, Hogdall E, Kjaer SK, Christensen L, Hogdall C, Easton DF, Jacobs I, Menon U, Pharoah PD, Gayther SA
Hum Mol Genet. 2009
PubMed ID: 19270026
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
Ding L, Paszkowski-Rogacz M, Nitzsche A, Slabicki MM, Heninger AK, de Vries I, Kittler R, Junqueira M, Shevchenko A, Schulz H, Hubner N, Doss MX, Sachinidis A, Hescheler J, Iacone R, Anastassiadis K, Stewart AF, Pisabarro MT, Caldarelli A, Poser I, Theis M, Buchholz F
Cell Stem Cell. 2009
PubMed ID: 19345177
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.
Foltz DR, Jansen LE, Bailey AO, Yates JR, Bassett EA, Wood S, Black BE, Cleveland DW
Cell. 2009
PubMed ID: 19410544
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.
Ouyang J, Shi Y, Valin A, Xuan Y, Gill G
Mol Cell. 2009
PubMed ID: 19394292
RAD51 foci formation in response to DNA damage is modulated by TIP49.
Gospodinov A, Tsaneva I, Anachkova B
Int J Biochem Cell Biol. 2009
PubMed ID: 18834951
In vitro nuclear interactome of the HIV-1 Tat protein.
Gautier VW, Gu L, O'Donoghue N, Pennington S, Sheehy N, Hall WW
Retrovirology. 2009
PubMed ID: 19454010
Human protein factory for converting the transcriptome into an in vitro-expressed proteome,.
Goshima N, Kawamura Y, Fukumoto A, Miura A, Honma R, Satoh R, Wakamatsu A, Yamamoto J, Kimura K, Nishikawa T, Andoh T, Iida Y, Ishikawa K, Ito E, Kagawa N, Kaminaga C, Kanehori K, Kawakami B, Kenmochi K, Kimura R, Kobayashi M, Kuroita T, Kuwayama H, Maruyama Y, Matsuo K, Minami K, Mitsubori M, Mori M, Morishita R, Murase A, Nishikawa A, Nishikawa S, Okamoto T, Sakagami N, Sakamoto Y, Sasaki Y, Seki T, Sono S, Sugiyama A, Sumiya T, Takayama T, Takayama Y, Takeda H, Togashi T, Yahata K, Yamada H, Yanagisawa Y, Endo Y, Imamoto F, Kisu Y, Tanaka S, Isogai T, Imai J, Watanabe S, Nomura N
Nat Methods. 2008
PubMed ID: 19054851
Phorbol ester enhances KAI1 transcription by recruiting Tip60/Pontin complexes.
Rowe A, Weiske J, Kramer TS, Huber O, Jackson P
Neoplasia. 2008
PubMed ID: 19048121
Pontin is localized in nucleolar fibrillar centers.
Cvacková Z, Albring KF, Koberna K, Ligasová A, Huber O, Raska I, Stanek D
Chromosoma. 2008
PubMed ID: 18548265
Cloning, expression, purification, crystallization and preliminary X-ray analysis of the human RuvBL1-RuvBL2 complex.
Gorynia S, Matias PM, Bandeiras TM, Donner P, Carrondo MA
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008
PubMed ID: 18765919
Regulation of microtubule assembly and organization in mitosis by the AAA+ ATPase Pontin.
Ducat D, Kawaguchi S, Liu H, Yates JR, Zheng Y
Mol Biol Cell. 2008
PubMed ID: 18463163
CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis.
Maeda Y, Suzuki T, Pan X, Chen G, Pan S, Bartman T, Whitsett JA
J Biol Chem. 2008
PubMed ID: 18372249
Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry.
Forsman A, Rüetschi U, Ekholm J, Rymo L
J Proteome Res. 2008
PubMed ID: 18457437
Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage.
Jha S, Shibata E, Dutta A
Mol Cell Biol. 2008
PubMed ID: 18285460
Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly.
Venteicher AS, Meng Z, Mason PJ, Veenstra TD, Artandi SE
Cell. 2008
PubMed ID: 18358808
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics.
Sardiu ME, Cai Y, Jin J, Swanson SK, Conaway RC, Conaway JW, Florens L, Washburn MP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18218781
Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.
DeRan M, Pulvino M, Greene E, Su C, Zhao J
Mol Cell Biol. 2008
PubMed ID: 17967892
SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells.
Kim JH, Lee JM, Nam HJ, Choi HJ, Yang JW, Lee JS, Kim MH, Kim SI, Chung CH, Kim KI, Baek SH
Proc Natl Acad Sci U S A. 2007
PubMed ID: 18087039
A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair.
Wu S, Shi Y, Mulligan P, Gay F, Landry J, Liu H, Lu J, Qi HH, Wang W, Nickoloff JA, Wu C, Shi Y
Nat Struct Mol Biol. 2007
PubMed ID: 18026119
Functional characterization of the OFD1 protein reveals a nuclear localization and physical interaction with subunits of a chromatin remodeling complex.
Giorgio G, Alfieri M, Prattichizzo C, Zullo A, Cairo S, Franco B
Mol Biol Cell. 2007
PubMed ID: 17761535
A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly.
McKeegan KS, Debieux CM, Boulon S, Bertrand E, Watkins NJ
Mol Cell Biol. 2007
PubMed ID: 17636026
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
YY1 functions with INO80 to activate transcription.
Cai Y, Jin J, Yao T, Gottschalk AJ, Swanson SK, Wu S, Shi Y, Washburn MP, Florens L, Conaway RC, Conaway JW
Nat Struct Mol Biol. 2007
PubMed ID: 17721549
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.
Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B
Mol Cell. 2007
PubMed ID: 17643375
RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation.
Hayakawa T, Ohtani Y, Hayakawa N, Shinmyozu K, Saito M, Ishikawa F, Nakayama J
Genes Cells. 2007
PubMed ID: 17573780
HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells.
Dall'Era MA, Oudes A, Martin DB, Liu AY
Prostate. 2007
PubMed ID: 17342744
Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex.
Puri T, Wendler P, Sigala B, Saibil H, Tsaneva IR
J Mol Biol. 2007
PubMed ID: 17157868
Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.
Cannavo E, Gerrits B, Marra G, Schlapbach R, Jiricny J
J Biol Chem. 2007
PubMed ID: 17148452
Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.
Koch HB, Zhang R, Verdoodt B, Bailey A, Zhang CD, Yates JR, Menssen A, Hermeking H
Cell Cycle. 2007
PubMed ID: 17314511
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Quantitative genetics of age-related retinal degeneration: a second F1 intercross between the A/J and C57BL/6 strains.
Danciger M, Yang H, Ralston R, Liu Y, Matthes MT, Peirce J, Lavail MM
Mol Vis. 2007
PubMed ID: 17277741
Crystal structure of the human AAA+ protein RuvBL1.
Matias PM, Gorynia S, Donner P, Carrondo MA
J Biol Chem. 2006
PubMed ID: 17060327
The DNA sequence, annotation and analysis of human chromosome 3.
Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA
Nature. 2006
PubMed ID: 16641997
Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.
Gomes NP, Bjerke G, Llorente B, Szostek SA, Emerson BM, Espinosa JM
Genes Dev. 2006
PubMed ID: 16510875
The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.
Sierra J, Yoshida T, Joazeiro CA, Jones KA
Genes Dev. 2006
PubMed ID: 16510874
ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.
Doyon Y, Cayrou C, Ullah M, Landry AJ, Côté V, Selleck W, Lane WS, Tan S, Yang XJ, Côté J
Mol Cell. 2006
PubMed ID: 16387653
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex.
Jin J, Cai Y, Yao T, Gottschalk AJ, Florens L, Swanson SK, Gutiérrez JL, Coleman MK, Workman JL, Mushegian A, Washburn MP, Conaway RC, Conaway JW
J Biol Chem. 2005
PubMed ID: 16230350
A mutually stimulating loop involving emx2 and canonical wnt signalling specifically promotes expansion of occipital cortex and hippocampus.
Muzio L, Soria JM, Pannese M, Piccolo S, Mallamaci A
Cereb Cortex. 2005
PubMed ID: 15800025
Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
WW domains provide a platform for the assembly of multiprotein networks.
Ingham RJ, Colwill K, Howard C, Dettwiler S, Lim CS, Yu J, Hersi K, Raaijmakers J, Gish G, Mbamalu G, Taylor L, Yeung B, Vassilovski G, Amin M, Chen F, Matskova L, Winberg G, Ernberg I, Linding R, O'donnell P, Starostine A, Keller W, Metalnikov P, Stark C, Pawson T
Mol Cell Biol. 2005
PubMed ID: 16055720
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J, Allis CD, Chait BT, Hess JL, Roeder RG
Cell. 2005
PubMed ID: 15960975
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes.
Kim JH, Kim B, Cai L, Choi HJ, Ohgi KA, Tran C, Chen C, Chung CH, Huber O, Rose DW, Sawyers CL, Rosenfeld MG, Baek SH
Nature. 2005
PubMed ID: 15829968
The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.
Cai Y, Jin J, Florens L, Swanson SK, Kusch T, Li B, Workman JL, Washburn MP, Conaway RC, Conaway JW
J Biol Chem. 2005
PubMed ID: 15647280
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
The highly conserved and multifunctional NuA4 HAT complex.
Doyon Y, Côté J
Curr Opin Genet Dev. 2004
PubMed ID: 15196461
Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.
Doyon Y, Selleck W, Lane WS, Tan S, Côté J
Mol Cell Biol. 2004
PubMed ID: 14966270
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling.
Feng Y, Lee N, Fearon ER
Cancer Res. 2003
PubMed ID: 14695187
Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a.
Carlson ML, Wilson ET, Prescott SM
Mol Cancer. 2003
PubMed ID: 14675489
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.
Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W
Science. 2003
PubMed ID: 14615539
Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.
Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW
J Biol Chem. 2003
PubMed ID: 12963728
The ATP-dependent helicase RUVBL1/TIP49a associates with tubulin during mitosis.
Gartner W, Rossbacher J, Zierhut B, Daneva T, Base W, Weissel M, Waldhäusl W, Pasternack MS, Wagner L
Cell Motil Cytoskeleton. 2003
PubMed ID: 14506706
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation.
Park J, Wood MA, Cole MD
Mol Cell Biol. 2002
PubMed ID: 11839798
Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis.
Jia L, Young MF, Powell J, Yang L, Ho NC, Hotchkiss R, Robey PG, Francomano CA
Genomics. 2002
PubMed ID: 11827452
The p400 complex is an essential E1A transformation target.
Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM
Cell. 2001
PubMed ID: 11509179
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Purification, cloning, and characterization of a profibrinolytic plasminogen-binding protein, TIP49a.
Hawley SB, Tamura T, Miles LA
J Biol Chem. 2001
PubMed ID: 11027681
Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity.
Bauer A, Chauvet S, Huber O, Usseglio F, Rothbächer U, Aragnol D, Kemler R, Pradel J
EMBO J. 2000
PubMed ID: 11080158
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis.
Ikura T, Ogryzko VV, Grigoriev M, Groisman R, Wang J, Horikoshi M, Scully R, Qin J, Nakatani Y
Cell. 2000
PubMed ID: 10966108
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc.
Wood MA, McMahon SB, Cole MD
Mol Cell. 2000
PubMed ID: 10882073
Chromosome mapping and expression of human tip49 family genes.
Makino Y, Kanemaki M, Koga A, Osano K, Matsu-Ura T, Kurokawa Y, Kishimoto T, Tamura T
DNA Seq. 2000
PubMed ID: 10902922
Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins.
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Biochim Biophys Acta. 1999
PubMed ID: 10524211
TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a.
Kanemaki M, Kurokawa Y, Matsu-ura T, Makino Y, Masani A, Okazaki K, Morishita T, Tamura TA
J Biol Chem. 1999
PubMed ID: 10428817
A rat RuvB-like protein, TIP49a, is a germ cell-enriched novel DNA helicase.
Makino Y, Kanemaki M, Kurokawa Y, Koji T, Tamura T
J Biol Chem. 1999
PubMed ID: 10336418
Molecular shape and ATP binding activity of rat p50, a putative mammalian homologue of RuvB DNA helicase.
Kikuchi N, Gohshi T, Kawahire S, Tachibana T, Yoneda Y, Isobe T, Lim CR, Kohno K, Ichimura T, Omata S, Horigome T
J Biochem. 1999
PubMed ID: 10050036
A notable example of an evolutionary conserved gene: studies on a putative DNA helicase TIP49.
Kurokawa Y, Kanemaki M, Makino Y, Tamura TA
DNA Seq. 1999
PubMed ID: 10565543
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein.
Bauer A, Huber O, Kemler R
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9843967
Identification and characterization of the ubiquitously occurring nuclear matrix protein NMP 238.
Holzmann K, Gerner C, Korosec T, Pöltl A, Grimm R, Sauermann G
Biochem Biophys Res Commun. 1998
PubMed ID: 9813143
An eukaryotic RuvB-like protein (RUVBL1) essential for growth.
Qiu XB, Lin YL, Thome KC, Pian P, Schlegel BP, Weremowicz S, Parvin JD, Dutta A
J Biol Chem. 1998
PubMed ID: 9774387
TIP49, homologous to the bacterial DNA helicase RuvB, acts as an autoantigen in human.
Makino Y, Mimori T, Koike C, Kanemaki M, Kurokawa Y, Inoue S, Kishimoto T, Tamura T
Biochem Biophys Res Commun. 1998
PubMed ID: 9588198
Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
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Gene. 1997
PubMed ID: 9373149
Molecular cloning of a rat 49-kDa TBP-interacting protein (TIP49) that is highly homologous to the bacterial RuvB.
Kanemaki M, Makino Y, Yoshida T, Kishimoto T, Koga A, Yamamoto K, Yamamoto M, Moncollin V, Egly JM, Muramatsu M, Tamura T
Biochem Biophys Res Commun. 1997
PubMed ID: 9196036
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
PubMed ID: 8125298
Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.
Dawson SJ, White LA
J Infect. 1992
PubMed ID: 1602151

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	8607	56505	65137
EnsEMBL Gene(s)	ENSG00000175792	ENSMUSG00000030079	ENSRNOG00000013195
Unigene	Hs.272822	Mm.42195	Rn.86410
Homologene	RUVBL1	Ruvbl1	Ruvbl1
OMIM	603449	N/A	N/A
GeneCards	RUVBL1	N/A	N/A
Beta Cell Genomics	DT.100726604 DT.100882736 DT.100882772 DT.118699 DT.120891067 DT.120891496 DT.91774522	DT.101377566 DT.110927621 DT.40152077 DT.91429858	N/A
Reactome	Q9Y265	N/A	N/A
Plasma Peptide Atlas	ENSP00000318297	N/A	N/A
WikiGenes	8607	56505	65137

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
RUVBL1	HDAC5	BioGRID	empirical	21081666
RUVBL1	CDK9	BioGRID	empirical	17643375
RUVBL1	SMNDC1	IntAct, BioGRID	empirical	17353931
RUVBL1	EIF1B	IntAct	empirical	17353931
RUVBL1	MCRS1	IntAct, BioGRID	empirical	16230350 17721549
RUVBL1	TAB1	MINT, IntAct	empirical	14743216
RUVBL1	ZNHIT1	IntAct	empirical	16230350 15647280
RUVBL1	KAT5	IntAct, BioGRID	empirical	10966108 16230350 15647280 18087039 14966270
RUVBL1	CENPA	IntAct, BioGRID	empirical	19410544
RUVBL1	PRPF8	IntAct, BioGRID	empirical	20360068
RUVBL1	SRCAP	IntAct	empirical	16230350
RUVBL1	RUVBL2	HPRD, IntAct, BioGRID, Sanger Interaction Map	empirical	11080158 10524211 10966108 18358808 17353931 20371770 16230350 17643375 17157868 20211142 19433865 18087039 17636026 20603076 17721549 15345047
RUVBL1	BRD8	IntAct	empirical	16230350
RUVBL1	MORF4L1	BioGRID	empirical	17573780 20332121 14966270
RUVBL1	RIPK3	MINT, IntAct	empirical	14743216
RUVBL1	WDR5	IntAct	empirical	15960975
RUVBL1	GPN1	BioGRID	empirical	17643375
RUVBL1	DDX42	BioGRID	empirical	17643375
RUVBL1	C12orf45	BioGRID	empirical	17643375
RUVBL1	INO80C	BioGRID	empirical	17721549
RUVBL1	MAP3K8	IntAct	empirical	14743216
RUVBL1	CREBBP	BioGRID	empirical	18087039
RUVBL1	E2F7	IntAct, BioGRID	empirical	17353931
RUVBL1	CTNNB1	HPRD, BioGRID	empirical	9843967 16510874 16510875 18087039
RUVBL1	DKC1	HPRD, IntAct	empirical	18358808
RUVBL1	DNASE2	IntAct, BioGRID	empirical	17353931
RUVBL1	DSG1	IntAct	empirical	17353931
RUVBL1	ELAVL1	BioGRID	empirical	17643375
RUVBL1	FBL	BioGRID	empirical	17636026
RUVBL1	ESR1	IntAct	empirical	21182205
RUVBL1	MED19	IntAct	empirical	15175163
RUVBL1	FDFT1	IntAct, BioGRID	empirical	17353931
RUVBL1	SMG1	IntAct	empirical	20371770
RUVBL1	TAB2	MINT, IntAct	empirical	14743216
RUVBL1	RPGRIP1L	IntAct	empirical	21565611
RUVBL1	FTSJ1	IntAct	empirical	17353931
RUVBL1	MTOR	IntAct	empirical	20371770
RUVBL1	DPCD	IntAct, BioGRID	empirical	17353931 17643375
RUVBL1	STAP1	BioGRID	empirical	14615539
RUVBL1	NUFIP1	BioGRID	empirical	17636026
RUVBL1	GNAS	IntAct, BioGRID	empirical	17353931
RUVBL1	INO80E	IntAct, BioGRID	empirical	21303910 18922472 16230350 17721549
RUVBL1	GRB2	IntAct	empirical	12577067
RUVBL1	TBK1	MINT, IntAct	empirical	14743216
RUVBL1	TFCP2L1	BioGRID	empirical	20362541
RUVBL1	TFPT	BioGRID	empirical	17721549
RUVBL1	H2AFX	BioGRID	empirical	18285460
RUVBL1	H2AFZ	BioGRID	empirical	17721549
RUVBL1	HLA-B	IntAct, BioGRID	empirical	17353931
RUVBL1	HSPA1L	BioGRID	empirical	17643375
RUVBL1	HSPA8	BioGRID	empirical	17643375
RUVBL1	GATS	IntAct	empirical	16230350
RUVBL1	EIF6	IntAct	empirical	17353931
RUVBL1	KCNMA1	IntAct	empirical	19423573
RUVBL1	ARF6	IntAct	empirical	17353931
RUVBL1	KPNB1	BioGRID	empirical	17643375
RUVBL1	MAP3K3	MINT, IntAct	empirical	14743216
RUVBL1	MLH1	BioGRID	empirical	17148452
RUVBL1	MME	IntAct, BioGRID	empirical	17342744
RUVBL1	MYC	IntAct, BioGRID	empirical	17314511 11509179 11839798
RUVBL1	ATM	IntAct	empirical	20371770
RUVBL1	NFKB1	MINT	empirical	14743216
RUVBL1	NFKB2	MINT	empirical	14743216
RUVBL1	NFRKB	BioGRID	empirical	17721549
RUVBL1	NHP2L1	BioGRID	empirical	20360068
RUVBL1	PCBP1	BioGRID	empirical	17643375
RUVBL1	PCBP2	BioGRID	empirical	17643375
RUVBL1	LEF1	BioGRID	empirical	9843967
RUVBL1	UCHL5	IntAct, BioGRID	empirical	18922472 17721549
RUVBL1	TRIM33	IntAct	empirical	20603019
RUVBL1	PLG	HPRD, BioGRID	empirical	11027681
RUVBL1	PELO	IntAct, BioGRID	empirical	17353931
RUVBL1	PCBP3	BioGRID	empirical	17643375
RUVBL1	POLR2E	IntAct	empirical	20371770
RUVBL1	ATR	IntAct	empirical	20371770
RUVBL1	INO80	IntAct, BioGRID	empirical	16230350 21303910 17721549
RUVBL1	INO80D	IntAct, BioGRID	empirical	16230350 17721549
RUVBL1	PIH1D1	IntAct, BioGRID	empirical	20371770 17643375 17636026
RUVBL1	CCDC87	BioGRID	empirical	17643375
RUVBL1	C20orf20	HPRD, IntAct, BioGRID	empirical	12963728 16230350 15647280 17573780
RUVBL1	HJURP	Reactome	predicted
RUVBL1	PRKDC	IntAct	empirical	20371770
RUVBL1	DMAP1	IntAct	empirical	20946988 16230350
RUVBL1	MAPK3	MINT	empirical	19935650
RUVBL1	MEPCE	BioGRID	empirical	17643375
RUVBL1	PSMA3	BioGRID	empirical	22079093
RUVBL1	SMARCAD1	BioGRID	empirical	21549307
RUVBL1	PLSCR4	IntAct	empirical	16230350
RUVBL1	KIAA1377	HPRD, MINT, IntAct, BioGRID	empirical	16169070
RUVBL1	EP400	BioGRID	empirical	11509179 18087039
RUVBL1	RARA	BioGRID	empirical	18087039
RUVBL1	RELA	MINT, IntAct	empirical	14743216
RUVBL1	RELB	MINT, IntAct	empirical	14743216
RUVBL1	ACTB	BioGRID	empirical	17643375
RUVBL1	ERVK-6	IntAct	empirical	16230350
RUVBL1	ACTR6	IntAct	empirical	16230350
RUVBL1	SLC2A4	IntAct	empirical	16396496
RUVBL1	SMARCA2	BioGRID	empirical	11839798
RUVBL1	SOX2	BioGRID	empirical	21532573
RUVBL1	SRI	BioGRID	empirical	17643375
RUVBL1	TAF9	BioGRID	empirical	17636026
RUVBL1	MAP3K7	MINT, IntAct	empirical	14743216
RUVBL1	TBP	HPRD, BioGRID	empirical	9843967
RUVBL1	TCF3	IntAct	empirical	16230350
RUVBL1	VPS72	IntAct	empirical	16230350 15647280
RUVBL1	TERT	IntAct	empirical	18358808
RUVBL1	TNFRSF1A	MINT, IntAct	empirical	14743216
RUVBL1	TRAF2	MINT, IntAct	empirical	14743216
RUVBL1	TRAF6	IntAct	empirical	17353931
RUVBL1	UBC	BioGRID	empirical	16196087 21139048 21890473 21906983
RUVBL1	UBE2I	BioGRID	empirical	18087039
RUVBL1	YY1	IntAct, BioGRID	empirical	18026119 17721549
RUVBL1	YWHAZ	MINT	empirical	15161933
RUVBL1	RPAP3	IntAct	empirical	20371770
RUVBL1	ACTR5	IntAct, BioGRID	empirical	16230350 17721549
RUVBL1	WWC2	IntAct	empirical	17353931
RUVBL1	TTI2	IntAct, BioGRID	empirical	20801936
RUVBL1	C2orf44	IntAct, BioGRID	empirical	17353931 18218781
RUVBL1	EPC1	IntAct	empirical	16230350
RUVBL1	YEATS4	IntAct, BioGRID	empirical	16230350 17643375
RUVBL1	LZTR1	BioGRID	empirical	20211142
RUVBL1	CAPNS1	BioGRID	empirical	17643375
RUVBL1	TRRAP	IntAct, BioGRID	empirical	20371770 11839798
RUVBL1	INO80B	IntAct, BioGRID	empirical	16230350 17721549
RUVBL1	EEA1	IntAct	empirical	17353931
RUVBL1	BCAR3	IntAct	empirical	17353931
RUVBL1	NTPCR	BioGRID	empirical	17643375
RUVBL1	MAP1LC3A	IntAct	empirical	20562859
RUVBL1	OFD1	BioGRID	empirical	17761535
RUVBL1	EAF1	IntAct	empirical	16230350
RUVBL1	ACTL6A	HPRD, IntAct, BioGRID	empirical	11839798 12963728 16230350 15647280 17721549
RUVBL1	URI1	IntAct	empirical	20371770
RUVBL1	MAP3K14	MINT, IntAct	empirical	14743216
RUVBL1	PSTPIP1	IntAct, BioGRID	empirical	17353931
RUVBL1	ACTR8	IntAct, BioGRID	empirical	16230350 17721549
RUVBL1	KIF20B	IntAct	empirical	17353931
RUVBL1	IKBKE	MINT, IntAct	empirical	14743216 17353931
RUVBL1	MORF4L2	BioGRID	empirical	17573780 20332121
RUVBL1	CTR9	BioGRID	empirical	19345177
RUVBL1	TTI1	IntAct, BioGRID	empirical	20371770 20801936 17643375
RUVBL1	KIAA0101	BioGRID	empirical	21628590
RUVBL1	TELO2	IntAct	empirical	20371770 20801936
RUVBL1	WDR1	BioGRID	empirical	19345177