CBX4

Summary Top Help

Gene Description:

chromobox homolog 4 (Drosophila Pc class); chromobox homolog 4

Synonyms:

NBP16, Cbx4, PC2, CBX4, MPc2

Orthologs:

Human CBX4 (protein-coding), Mouse Cbx4 (protein-coding), Rat Cbx4 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr17:77806955..77813228 (6.27 kb) View in Genome Browser

(Mouse) NCBIM37 - chr11:118938885..118947551 (8.67 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CBX4:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
								no data	no data	no data	no data	no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CBX4:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: 1

Reactome: None available

NCI-Nature Pathway Interaction Database: 2

Gene Ontology: 17

Publications from PubMed Top Help

Publications: 64

Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics.
Yang W, Thompson JW, Wang Z, Wang L, Sheng H, Foster MW, Moseley MA, Paschen W
J Proteome Res. 2012
PubMed ID: 22082260
ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs.
Yang L, Lin C, Liu W, Zhang J, Ohgi KA, Grinstein JD, Dorrestein PC, Rosenfeld MG
Cell. 2011
PubMed ID: 22078878
Regulation of human epidermal stem cell proliferation and senescence requires polycomb- dependent and -independent functions of Cbx4.
Luis NM, Morey L, Mejetta S, Pascual G, Janich P, Kuebler B, Cozutto L, Roma G, Nascimento E, Frye M, Di Croce L, Benitah SA
Cell Stem Cell. 2011
PubMed ID: 21885019
Histone methylation by PRC2 is inhibited by active chromatin marks.
Schmitges FW, Prusty AB, Faty M, Stützer A, Lingaraju GM, Aiwazian J, Sack R, Hess D, Li L, Zhou S, Bunker RD, Wirth U, Bouwmeester T, Bauer A, Ly-Hartig N, Zhao K, Chan H, Gu J, Gut H, Fischle W, Müller J, Thomä NH
Mol Cell. 2011
PubMed ID: 21549310
SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b.
Dütting E, Schröder-Kress N, Sticht H, Enz R
Biochem J. 2011
PubMed ID: 21288202
Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.
Vandamme J, Völkel P, Rosnoblet C, Le Faou P, Angrand PO
Mol Cell Proteomics. 2011
PubMed ID: 21282530
Human Polycomb protein 2 promotes α-synuclein aggregate formation through covalent SUMOylation.
Oh Y, Kim YM, Mouradian MM, Chung KC
Brain Res. 2011
PubMed ID: 21256122
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1.
Tan JA, Song J, Chen Y, Durrin LK
Mol Cell Biol. 2010
PubMed ID: 20351170
Inhibition of CtBP1 activity by Akt-mediated phosphorylation.
Merrill JC, Kagey MH, Melhuish TA, Powers SE, Zerlanko BJ, Wotton D
J Mol Biol. 2010
PubMed ID: 20361981
The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif.
Yang SH, Sharrocks AD
Mol Cell Biol. 2010
PubMed ID: 20176810
Huntingtin facilitates polycomb repressive complex 2.
Seong IS, Woda JM, Song JJ, Lloret A, Abeyrathne PD, Woo CJ, Gregory G, Lee JM, Wheeler VC, Walz T, Kingston RE, Gusella JF, Conlon RA, Macdonald ME
Hum Mol Genet. 2010
PubMed ID: 19933700
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.
Zhou W, Chen H, Zhang L
BMB Rep. 2009
PubMed ID: 19336002
Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.
Maertens GN, El Messaoudi-Aubert S, Racek T, Stock JK, Nicholls J, Rodriguez-Niedenführ M, Gil J, Peters G
PLoS One. 2009
PubMed ID: 19636380
In vitro nuclear interactome of the HIV-1 Tat protein.
Gautier VW, Gu L, O'Donoghue N, Pennington S, Sheehy N, Hall WW
Retrovirology. 2009
PubMed ID: 19454010
Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.
Wang B, Malik R, Nigg EA, Körner R
Anal Chem. 2008
PubMed ID: 19007248
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
RanBPM is expressed in synaptic layers of the mammalian retina and binds to metabotropic glutamate receptors.
Seebahn A, Rose M, Enz R
FEBS Lett. 2008
PubMed ID: 18555800
Polycomb group protein-associated chromatin is reproduced in post-mitotic G1 phase and is required for S phase progression.
Aoto T, Saitoh N, Sakamoto Y, Watanabe S, Nakao M
J Biol Chem. 2008
PubMed ID: 18453536
Polycystin-2 is regulated by endoplasmic reticulum-associated degradation.
Liang G, Li Q, Tang Y, Kokame K, Kikuchi T, Wu G, Chen XZ
Hum Mol Genet. 2008
PubMed ID: 18178578
PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.
Puschendorf M, Terranova R, Boutsma E, Mao X, Isono K, Brykczynska U, Kolb C, Otte AP, Koseki H, Orkin SH, van Lohuizen M, Peters AH
Nat Genet. 2008
PubMed ID: 18311137
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
DNA methyltransferase 3B acts as a co-repressor of the human polycomb protein hPc2 to repress fibroblast growth factor receptor 3 transcription.
Kim SH, Park J, Choi MC, Park JH, Kim HP, Lee JH, Oh DY, Im SA, Bang YJ, Kim TY
Int J Biochem Cell Biol. 2008
PubMed ID: 18567530
Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction.
Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI
Gene Expr Patterns. 2008
PubMed ID: 18023262
Polycomb protein Cbx4 promotes SUMO modification of de novo DNA methyltransferase Dnmt3a.
Li B, Zhou J, Liu P, Hu J, Jin H, Shimono Y, Takahashi M, Xu G
Biochem J. 2007
PubMed ID: 17439403
Overlapping roles of the methylated DNA-binding protein MBD1 and polycomb group proteins in transcriptional repression of HOXA genes and heterochromatin foci formation.
Sakamoto Y, Watanabe S, Ichimura T, Kawasuji M, Koseki H, Baba H, Nakao M
J Biol Chem. 2007
PubMed ID: 17428788
Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor.
Sánchez C, Sánchez I, Demmers JA, Rodriguez P, Strouboulis J, Vidal M
Mol Cell Proteomics. 2007
PubMed ID: 17296600
Opposing LSD1 complexes function in developmental gene activation and repression programmes.
Wang J, Scully K, Zhu X, Cai L, Zhang J, Prefontaine GG, Krones A, Ohgi KA, Zhu P, Garcia-Bassets I, Liu F, Taylor H, Lozach J, Jayes FL, Korach KS, Glass CK, Fu XD, Rosenfeld MG
Nature. 2007
PubMed ID: 17392792
Human cystathionine beta-synthase is a target for sumoylation.
Kabil O, Zhou Y, Banerjee R
Biochemistry. 2006
PubMed ID: 17087506
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.
Roscic A, Möller A, Calzado MA, Renner F, Wimmer VC, Gresko E, Lüdi KS, Schmitz ML
Mol Cell. 2006
PubMed ID: 17018294
Differential expression of polycomb repression complex 1 (PRC1) members in the developing mouse brain reveals multiple complexes.
Vogel T, Stoykova A, Gruss P
Dev Dyn. 2006
PubMed ID: 16786585
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C
Nature. 2006
PubMed ID: 16625196
Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin.
Bernstein E, Duncan EM, Masui O, Gil J, Heard E, Allis CD
Mol Cell Biol. 2006
PubMed ID: 16537902
Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.
Long J, Zuo D, Park M
J Biol Chem. 2005
PubMed ID: 16061479
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1.
Voncken JW, Niessen H, Neufeld B, Rennefahrt U, Dahlmans V, Kubben N, Holzer B, Ludwig S, Rapp UR
J Biol Chem. 2005
PubMed ID: 15563468
The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2.
Qin H, Du D, Zhu Y, Li J, Feng L, Liang Y, Han H
FEBS Lett. 2005
PubMed ID: 15710417
Multiple activities contribute to Pc2 E3 function.
Kagey MH, Melhuish TA, Powers SE, Wotton D
EMBO J. 2005
PubMed ID: 15592428
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Functional proteomics mapping of a human signaling pathway.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM
Genome Res. 2004
PubMed ID: 15231748
A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.
Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW
J Biol Chem. 2004
PubMed ID: 14638676
MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein.
Xia ZB, Anderson M, Diaz MO, Zeleznik-Le NJ
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12829790
Coordinated histone modifications mediated by a CtBP co-repressor complex.
Shi Y, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F, Ogawa H, Luke MP, Nakatani Y, Shi Y
Nature. 2003
PubMed ID: 12700765
The polycomb protein Pc2 is a SUMO E3.
Kagey MH, Melhuish TA, Wotton D
Cell. 2003
PubMed ID: 12679040
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.
Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE
Mol Cell Biol. 2002
PubMed ID: 12167701
Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins.
Sewalt RG, Lachner M, Vargas M, Hamer KM, den Blaauwen JL, Hendrix T, Melcher M, Schweizer D, Jenuwein T, Otte AP
Mol Cell Biol. 2002
PubMed ID: 12101246
Linking the Rb and polycomb pathways.
Dahiya A, Wong S, Gonzalo S, Gavin M, Dean DC
Mol Cell. 2001
PubMed ID: 11583618
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Identification and analysis of a third mouse Polycomb gene, MPc3.
Hemenway CS, Halligan BW, Gould GC, Levy LS
Gene. 2000
PubMed ID: 10721694
C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins.
Sewalt RG, Gunster MJ, van der Vlag J, Satijn DP, Otte AP
Mol Cell Biol. 1999
PubMed ID: 9858600
RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity.
Satijn DP, Otte AP
Mol Cell Biol. 1999
PubMed ID: 9858531
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex.
Alkema MJ, Jacobs J, Voncken JW, Jenkins NA, Copeland NG, Satijn DP, Otte AP, Berns A, van Lohuizen M
J Mol Biol. 1997
PubMed ID: 9367786
Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis.
Satijn DP, Olson DJ, van der Vlag J, Hamer KM, Lambrechts C, Masselink H, Gunster MJ, Sewalt RG, van Driel R, Otte AP
Mol Cell Biol. 1997
PubMed ID: 9315667
RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.
Satijn DP, Gunster MJ, van der Vlag J, Hamer KM, Schul W, Alkema MJ, Saurin AJ, Freemont PS, van Driel R, Otte AP
Mol Cell Biol. 1997
PubMed ID: 9199346
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	8535	12418	501403
EnsEMBL Gene(s)	ENSG00000141582	ENSMUSG00000039989	N/A
Unigene	Hs.730763	Mm.268070	Rn.124378
Homologene	CBX4	Cbx4	Cbx4
OMIM	603079	N/A	N/A
GeneCards	CBX4	N/A	N/A
Beta Cell Genomics	DT.207354 DT.95369650	DT.484820 DT.91325255 DT.91326326	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	8535	12418	501403

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
CBX4	SSX10	IntAct	empirical	21282530
CBX4	CENPF	IntAct	empirical	21282530
CBX4	KDM5B	BioGRID	empirical	19336002
CBX4	RUVBL2	IntAct	empirical	21282530
CBX4	YWHAQ	IntAct	empirical	21282530
CBX4	WDHD1	IntAct	empirical	21282530
CBX4	CSNK2A1	IntAct	empirical	21282530
CBX4	CSNK2A2	IntAct	empirical	21282530
CBX4	CSNK2B	IntAct	empirical	21282530
CBX4	CTBP1	HPRD, BioGRID	empirical	15592428 12829790 12679040 11583618 9858600 20361981
CBX4	CTBP2	HPRD, BioGRID	empirical	9858600
CBX4	DNMT3A	BioGRID	empirical	17439403
CBX4	PHC1	IntAct, BioGRID	empirical	21282530 9199346
CBX4	PHC2	IntAct	empirical	21282530
CBX4	KHDRBS2	IntAct	empirical	21282530
CBX4	ERCC6	IntAct	empirical	21282530
CBX4	FER	IntAct	empirical	21282530
CBX4	FHL1	HPRD, MINT	empirical	15710417
CBX4	SMG1	IntAct	empirical	21282530
CBX4	SFN	IntAct	empirical	21282530
CBX4	GRM4	BioGRID	empirical	21288202
CBX4	GRM6	BioGRID	empirical	21288202
CBX4	GRM7	BioGRID	empirical	21288202
CBX4	GRM8	BioGRID	empirical	21288202 18555800
CBX4	SLC25A5	IntAct	empirical	21282530
CBX4	HIST1H1A	IntAct	empirical	21282530
CBX4	ZNF546	IntAct	empirical	21282530
CBX4	CCDC158	IntAct	empirical	21282530
CBX4	MKI67	IntAct	empirical	21282530
CBX4	MOV10	IntAct	empirical	21282530
CBX4	ASAP1	IntAct	empirical	21282530
CBX4	MED9	HPRD	empirical	14638676
CBX4	CHD7	IntAct	empirical	21282530
CBX4	RNF17	IntAct	empirical	21282530
CBX4	MDM1	IntAct	empirical	21282530
CBX4	CBX8	MINT	empirical	17332741
CBX4	STAMBPL1	IntAct	empirical	21282530
CBX4	RB1	HPRD, BioGRID	empirical	11583618
CBX4	RING1	HPRD, IntAct, BioGRID	empirical	9199346 9858531 21282530
CBX4	RNF2	HPRD, MINT, IntAct, BioGRID	empirical	16169070 17296600 21282530
CBX4	SATB1	IntAct, BioGRID	empirical	18408014 20351170
CBX4	BMI1	MINT, IntAct, BioGRID	empirical	17332741 12167701 21282530 19636380 12829790 9199346 18453536
CBX4	SKIL	HPRD, MINT	empirical	15231748
CBX4	SUMO3	BioGRID	empirical	22082260
CBX4	SUV39H1	BioGRID	empirical	12101246
CBX4	UBC	BioGRID	empirical	18781797 21906983
CBX4	UBE2I	HPRD	empirical	12679040
CBX4	YWHAB	IntAct	empirical	21282530
CBX4	YWHAE	IntAct	empirical	21282530
CBX4	YWHAG	IntAct	empirical	21282530
CBX4	YWHAH	IntAct	empirical	21282530
CBX4	YWHAZ	IntAct	empirical	21282530
CBX4	PCGF2	IntAct, BioGRID	empirical	21282530 19636380
CBX4	PHC3	IntAct	empirical	21282530
CBX4	HIST3H3	BioGRID	empirical	12700765
CBX4	PCGF6	IntAct	empirical	21282530
CBX4	CBX2	IntAct, BioGRID	empirical	12167701
CBX4	CBX4	IntAct	empirical	21282530
CBX4	SMC3	IntAct	empirical	21282530