CUL2

Summary Top Help

Gene Description:

cullin 2

Synonyms:

AI327301, 4932411N15Rik, mKIAA4106, 1300003D18Rik, Cul2, CUL2

Orthologs:

Human CUL2 (protein-coding), Mouse Cul2 (protein-coding), Rat Cul2 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd21.3	Mouse	chr18:1..21671921	21.67	95

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr10:35297479..35379570 (829 kb) View in Genome Browser

(Mouse) NCBIM37 - chr18:3382986..3436698 (53.71 kb) View in Genome Browser

(Rat) RGSC3.4 - chr17:62701289..62741344 (405 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CUL2:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CUL2:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 3

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 10

Publications from PubMed Top Help

Publications: 108

Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
Proteomic dissection of the von Hippel-Lindau (VHL) interactome.
Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y
J Proteome Res. 2011
PubMed ID: 21942715
COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
Mao X, Gluck N, Chen B, Starokadomskyy P, Li H, Maine GN, Burstein E
J Biol Chem. 2011
PubMed ID: 21778237
The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters.
Costessi A, Mahrour N, Tijchon E, Stunnenberg R, Stoel MA, Jansen PW, Sela D, Martin-Brown S, Washburn MP, Florens L, Conaway JW, Conaway RC, Stunnenberg HG
EMBO J. 2011
PubMed ID: 21822215
An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.
Litterman N, Ikeuchi Y, Gallardo G, O'Connell BC, Sowa ME, Gygi SP, Harper JW, Bonni A
PLoS Biol. 2011
PubMed ID: 21572988
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo.
Chua YS, Boh BK, Ponyeam W, Hagen T
PLoS One. 2011
PubMed ID: 21249194
Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.
Nie L, Zhao Y, Wu W, Yang YZ, Wang HC, Sun XH
Cell Res. 2010
PubMed ID: 21119685
De novo DNA methyltransferase DNMT3b interacts with NEDD8-modified proteins.
Shamay M, Greenway M, Liao G, Ambinder RF, Hayward SD
J Biol Chem. 2010
PubMed ID: 20847044
Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
Xu G, Paige JS, Jaffrey SR
Nat Biotechnol. 2010
PubMed ID: 20639865
Network organization of the human autophagy system.
Behrends C, Sowa ME, Gygi SP, Harper JW
Nature. 2010
PubMed ID: 20562859
Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients.
Törkvist L, Halfvarson J, Ong RT, Lördal M, Sjöqvist U, Bresso F, Björk J, Befrits R, Löfberg R, Blom J, Carlson M, Padyukov L, D'Amato M, Seielstad M, Pettersson S
Inflamm Bowel Dis. 2010
PubMed ID: 19760754
Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B.
Li XS, Trojer P, Matsumura T, Treisman JE, Tanese N
Mol Cell Biol. 2010
PubMed ID: 20086098
PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2.
Choy MK, Movassagh M, Bennett MR, Foo RS
J Cell Physiol. 2010
PubMed ID: 19950214
Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.
Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL
J Biol Chem. 2010
PubMed ID: 19940151
Mutational analysis of hypoxia-related genes HIF1alpha and CUL2 in common human cancers.
Park SW, Chung NG, Hur SY, Kim HS, Yoo NJ, Lee SH
APMIS. 2009
PubMed ID: 20078552
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag.
Nishi M, Ryo A, Tsurutani N, Ohba K, Sawasaki T, Morishita R, Perrem K, Aoki I, Morikawa Y, Yamamoto N
FEBS Lett. 2009
PubMed ID: 19327355
Oxygen-independent degradation of HIF-alpha via bioengineered VHL tumour suppressor complex.
Sufan RI, Moriyama EH, Mariampillai A, Roche O, Evans AJ, Alajez NM, Vitkin IA, Yang VX, Liu FF, Wilson BC, Ohh M
EMBO Mol Med. 2009
PubMed ID: 20049704
GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA.
Mao X, Gluck N, Li D, Maine GN, Li H, Zaidi IW, Repaka A, Mayo MW, Burstein E
Genes Dev. 2009
PubMed ID: 19339690
Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination.
Geng H, Wittwer T, Dittrich-Breiholz O, Kracht M, Schmitz ML
EMBO Rep. 2009
PubMed ID: 19270718
KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise.
Argyropoulos G, Stütz AM, Ilnytska O, Rice T, Teran-Garcia M, Rao DC, Bouchard C, Rankinen T
Physiol Genomics. 2009
PubMed ID: 18984674
Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.
Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS
Sci Signal. 2009
PubMed ID: 19584355
SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B
J Biol Chem. 2008
PubMed ID: 18826954
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.
Alexandru G, Graumann J, Smith GT, Kolawa NJ, Fang R, Deshaies RJ
Cell. 2008
PubMed ID: 18775313
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis.
Maeda Y, Suzuki T, Pan X, Chen G, Pan S, Bartman T, Whitsett JA
J Biol Chem. 2008
PubMed ID: 18372249
VHL type 2B mutations retain VBC complex form and function.
Hacker KE, Lee CM, Rathmell WK
PLoS One. 2008
PubMed ID: 19030229
Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome.
Menon S, Tsuge T, Dohmae N, Takio K, Wei N
BMC Biochem. 2008
PubMed ID: 18173839
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.
Ferguson JE, Wu Y, Smith K, Charles P, Powers K, Wang H, Patterson C
Mol Cell Biol. 2007
PubMed ID: 17636018
Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor.
Huh K, Zhou X, Hayakawa H, Cho JY, Libermann TA, Jin J, Harper JW, Munger K
J Virol. 2007
PubMed ID: 17609271
A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination.
Starostina NG, Lim JM, Schvarzstein M, Wells L, Spence AM, Kipreos ET
Dev Cell. 2007
PubMed ID: 17609115
Substrate-mediated regulation of cullin neddylation.
Chew EH, Hagen T
J Biol Chem. 2007
PubMed ID: 17439941
Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
Kaltenbach LS, Romero E, Becklin RR, Chettier R, Bell R, Phansalkar A, Strand A, Torcassi C, Savage J, Hurlburt A, Cha GH, Ukani L, Chepanoske CL, Zhen Y, Sahasrabudhe S, Olson J, Kurschner C, Ellerby LM, Peltier JM, Botas J, Hughes RE
PLoS Genet. 2007
PubMed ID: 17500595
Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase.
Elliott J, Lynch OT, Suessmuth Y, Qian P, Boyd CR, Burrows JF, Buick R, Stevenson NJ, Touzelet O, Gadina M, Power UF, Johnston JA
J Virol. 2007
PubMed ID: 17251292
TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation.
Shiraishi S, Zhou C, Aoki T, Sato N, Chiba T, Tanaka K, Yoshida S, Nabeshima Y, Nabeshima Y, Tamura TA
J Biol Chem. 2007
PubMed ID: 17242400
The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components.
Vasudevan S, Starostina NG, Kipreos ET
EMBO Rep. 2007
PubMed ID: 17304241
COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase.
Maine GN, Mao X, Komarck CM, Burstein E
EMBO J. 2007
PubMed ID: 17183367
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.
Dai J, Jin WH, Sheng QH, Shieh CH, Wu JR, Zeng R
J Proteome Res. 2007
PubMed ID: 17203969
Role of the NEDD8 modification of Cul2 in the sequential activation of ECV complex.
Sufan RI, Ohh M
Neoplasia. 2006
PubMed ID: 17132228
EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors.
Cai QL, Knight JS, Verma SC, Zald P, Robertson ES
PLoS Pathog. 2006
PubMed ID: 17069461
A global genomic transcriptional code associated with CNS-expressed genes.
Bailey PJ, Klos JM, Andersson E, Karlén M, Källström M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J
Exp Cell Res. 2006
PubMed ID: 16919269
A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.
Li T, Santockyte R, Shen RF, Tekle E, Wang G, Yang DC, Chock PB
Arch Biochem Biophys. 2006
PubMed ID: 16620772
Dynamic HIF1A regulation during human placental development.
Ietta F, Wu Y, Winter J, Xu J, Wang J, Post M, Caniggia I
Biol Reprod. 2006
PubMed ID: 16611863
Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications.
Norman JA, Shiekhattar R
Biochemistry. 2006
PubMed ID: 16503656
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A
Am J Hum Genet. 2006
PubMed ID: 16385451
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
CAND1 enhances deneddylation of CUL1 by COP9 signalosome.
Min KW, Kwon MJ, Park HS, Park Y, Yoon SK, Yoon JB
Biochem Biophys Res Commun. 2005
PubMed ID: 16036220
Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex.
Megumi Y, Miyauchi Y, Sakurai H, Nobeyama H, Lorick K, Nakamura E, Chiba T, Tanaka K, Weissman AM, Kirisako T, Ogawa O, Iwai K
Genes Cells. 2005
PubMed ID: 15966899
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway RC, Conaway JW, Nakayama KI
Genes Dev. 2004
PubMed ID: 15601820
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M
Mol Cell Biol. 2004
PubMed ID: 15572695
Identification of Elongin C and Skp1 sequences that determine Cullin selection.
Yan Q, Kamura T, Cai Y, Jin J, Ivan M, Mushegian A, Conaway RC, Conaway JW
J Biol Chem. 2004
PubMed ID: 15280393
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage.
Hu J, McCall CM, Ohta T, Xiong Y
Nat Cell Biol. 2004
PubMed ID: 15448697
The DNA sequence and comparative analysis of human chromosome 10.
Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J
Nature. 2004
PubMed ID: 15164054
pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development.
Stickle NH, Chung J, Klco JM, Hill RP, Kaelin WG, Ohh M
Mol Cell Biol. 2004
PubMed ID: 15060148
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
Nedd8 on cullin: building an expressway to protein destruction.
Pan ZQ, Kentsis A, Dias DC, Yamoah K, Wu K
Oncogene. 2004
PubMed ID: 15021886
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
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PubMed ID: 14702039
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
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Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
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Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
TIP120A associates with cullins and modulates ubiquitin ligase activity.
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J Biol Chem. 2003
PubMed ID: 12609982
von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination.
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Proc Natl Acad Sci U S A. 2003
PubMed ID: 12604794
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
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PubMed ID: 12520002
CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.
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Proc Natl Acad Sci U S A. 2002
PubMed ID: 12481031
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Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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Nature. 2002
PubMed ID: 12466851
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.
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Mol Cell. 2002
PubMed ID: 12504026
A molecular basis for stabilization of the von Hippel-Lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase.
Kamura T, Brower CS, Conaway RC, Conaway JW
J Biol Chem. 2002
PubMed ID: 12048197
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.
Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW, Conaway RC
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12149480
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP
Science. 2002
PubMed ID: 12004076
Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins.
Furukawa M, Ohta T, Xiong Y
J Biol Chem. 2002
PubMed ID: 11861641
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
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Nature. 2002
PubMed ID: 11961546
The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1.
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Curr Biol. 2002
PubMed ID: 11967155
Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity.
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Mol Cell Biol. 2002
PubMed ID: 11865071
An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.
Ohh M, Kim WY, Moslehi JJ, Chen Y, Chau V, Read MA, Kaelin WG
EMBO Rep. 2002
PubMed ID: 11818338
Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.
Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW
J Biol Chem. 2001
PubMed ID: 11384984
Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.
Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ
Science. 2001
PubMed ID: 11337588
The sequence of the human genome.
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Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
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Proc Natl Acad Sci U S A. 2000
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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.
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Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
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Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

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	Human	Mouse	Rat
Entrez Gene	8453	71745	361258
EnsEMBL Gene(s)	ENSG00000108094	ENSMUSG00000024231	ENSRNOG00000015292
Unigene	Hs.82919	Mm.291707	Rn.2970
Homologene	CUL2	Cul2	Cul2
OMIM	603135	N/A	N/A
GeneCards	CUL2	N/A	N/A
Beta Cell Genomics	DT.443924 DT.75164500	DT.534400 DT.94376449 DT.97408487	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	8453	71745	361258

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Interactor	Interactor	Sources	Classification	Pubmed IDs
CUL2	FEM1B	IntAct	empirical	15601820
CUL2	ZER1	HPRD, MINT, IntAct	empirical	17304241
CUL2	COPS6	IntAct, BioGRID	empirical	19615732
CUL2	COPS5	IntAct, BioGRID	empirical	19615732 18850735
CUL2	FAF1	IntAct, BioGRID	empirical	18775313
CUL2	PTP4A3	IntAct	empirical	17353931
CUL2	MED8	IntAct, BioGRID	empirical	12149480
CUL2	LRR1	IntAct	empirical	15601820
CUL2	CMBL	IntAct, BioGRID	empirical	17353931
CUL2	COMMD1	HPRD, MINT, BioGRID	empirical	17183367 21778237 19339690
CUL2	ADRB2	BioGRID	empirical	19584355
CUL2	DLG3	IntAct, BioGRID	empirical	17353931
CUL2	DNMT3B	BioGRID	empirical	20847044
CUL2	STOM	IntAct, BioGRID	empirical	17353931
CUL2	KLHDC10	IntAct, BioGRID	empirical	20562859
CUL2	FAF2	IntAct, BioGRID	empirical	18775313
CUL2	FOS	IntAct	empirical	20195357
CUL2	UBXN7	IntAct, BioGRID	empirical	18775313
CUL2	WSB1	BioGRID	empirical	11384984
CUL2	FBXW8	BioGRID	empirical	21572988
CUL2	KAT2A	BioGRID	empirical	19339690
CUL2	TIMM13	IntAct, BioGRID	empirical	17353931
CUL2	GH1	IntAct	empirical	17353931
CUL2	GPS1	HPRD	empirical	11337588
CUL2	NR3C1	IntAct	empirical	20195357
CUL2	HIF1A	BioGRID	empirical	17439941 17132228 19940151 19950214
CUL2	ARNT	BioGRID	empirical	20049704
CUL2	MAGEA6	IntAct	empirical	17353931
CUL2	MCC	IntAct	empirical	17353931
CUL2	RPL35P5	BioGRID	empirical	17353931
CUL2	MYOG	BioGRID	empirical	17242400
CUL2	NEDD8	HPRD, BioGRID	empirical	16620772 18173839 17132228
CUL2	P4HB	IntAct, BioGRID	empirical	17353931
CUL2	UBXN1	IntAct, BioGRID	empirical	18775313
CUL2	SH3GLB1	IntAct, BioGRID	empirical	20562859
CUL2	ASB4	BioGRID	empirical	17636018
CUL2	ASB2	BioGRID	empirical	21119685
CUL2	CAB39	IntAct, BioGRID	empirical	17353931
CUL2	PFKFB3	IntAct, BioGRID	empirical	17353931
CUL2	DCUN1D1	BioGRID	empirical	18826954
CUL2	KCTD5	IntAct, BioGRID	empirical	17353931
CUL2	RNMTL1	IntAct, BioGRID	empirical	17353931
CUL2	CAND1	HPRD, IntAct, BioGRID	empirical	12609982 12504026 18173839 21778237 21249194
CUL2	NSFL1C	IntAct, BioGRID	empirical	18775313
CUL2	ARID1B	BioGRID	empirical	20086098
CUL2	RELA	BioGRID	empirical	19270718
CUL2	TCEB1	HPRD, MINT, IntAct, MIPS, BioGRID	empirical	9447969 17183367 15601820 11384984 15966899 19339690
CUL2	TCEB2	IntAct, BioGRID	empirical	15601820 12149480 11384984 18173839 15966899 12048197
CUL2	TFE3	IntAct, BioGRID	empirical	17353931
CUL2	UBC	BioGRID	empirical	20639865 21987572 21139048 21890473 21906983
CUL2	UBE2D1	BioGRID	empirical	17132228
CUL2	VCP	IntAct, BioGRID	empirical	18775313
CUL2	VHL	HPRD, MINT, IntAct, MIPS, BioGRID	empirical	9122164 18323857 17353931 15601820 9447969 9751722 10587522 11384984 19030229 18173839 17439941 16611863 15966899 12048197 12604794 11865071 10823831 10421634 17132228 20049704 15060148 21942715
CUL2	SAP130	BioGRID	empirical	18173839
CUL2	ZYG11B	HPRD, MINT, IntAct	empirical	17304241
CUL2	ARID1A	BioGRID	empirical	20086098
CUL2	SOCS1	BioGRID	empirical	11384984
CUL2	TCEAL1	IntAct, BioGRID	empirical	19615732
CUL2	RNF7	HPRD	empirical	10230407
CUL2	KEAP1	BioGRID	empirical	15572695
CUL2	RBX1	MINT, IntAct, BioGRID, Reactome	empirical	17183367 15601820 12149480 12481031 11384984 10230407 15448697 11861641 21778237 17132228 19037258