CASP8

Summary Top Help

Gene Description:

caspase 8; caspase 8, apoptosis-related cysteine peptidase

Synonyms:

Casp8, Casp-8, CASP8, MCH5, MACH, CASP-8, ALPS2B, FLICE, Mch5, CAP4

Orthologs:

Human CASP8 (protein-coding), Mouse Casp8 (protein-coding), Rat Casp8 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr2:202098166..202152434 (54.27 kb) View in Genome Browser

(Mouse) NCBIM37 - chr1:58852218..58904347 (52.13 kb) View in Genome Browser

(Rat) RGSC3.4 - chr9:57389353..57437803 (48.45 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CASP8:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CASP8:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 12

Biocarta: 9

Reactome: 13

NCI-Nature Pathway Interaction Database: 8

Gene Ontology: 48

Angiogenesis	GO:0001525
Neural tube formation	GO:0001841
Cysteine-type endopeptidase activity	GO:0004197
Tumor necrosis factor receptor binding	GO:0005164
Protein binding	GO:0005515
Nucleus	GO:0005634
Nucleolus	GO:0005730
Cytoplasm	GO:0005737
Mitochondrion	GO:0005739
Mitochondrial outer membrane	GO:0005741
Centrosome	GO:0005813
Cytosol	GO:0005829
Cytoskeleton	GO:0005856
Proteolysis	GO:0006508
Apoptotic process	GO:0006915
Activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0006919
Cellular component disassembly involved in apoptosis	GO:0006921
Heart development	GO:0007507
Metabolic process	GO:0008152
Peptidase activity	GO:0008233
Cysteine-type peptidase activity	GO:0008234
Induction of apoptosis by extracellular signals	GO:0008624
Induction of apoptosis by intracellular signals	GO:0008629
Activation of pro-apoptotic gene products	GO:0008633
Response to cold	GO:0009409
Macrophage differentiation	GO:0030225
Noc1p-Noc2p complex	GO:0030690
Death-inducing signaling complex	GO:0031264
CD95 death-inducing signaling complex	GO:0031265
Response to cobalt ion	GO:0032025
Response to estradiol stimulus	GO:0032355
Response to lipopolysaccharide	GO:0032496
Response to tumor necrosis factor	GO:0034612
Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:0035872
Identical protein binding	GO:0042802
Regulation of apoptotic process	GO:0042981
Neuron projection	GO:0043005
Positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:0043123
Cell body	GO:0044297
Innate immune response	GO:0045087
Membrane raft	GO:0045121
Response to ethanol	GO:0045471
Response to antibiotic	GO:0046677
Protein heterooligomerization	GO:0051291
Proteolysis involved in cellular protein catabolic process	GO:0051603
Nucleotide-binding oligomerization domain containing signaling pathway	GO:0070423
Cellular response to mechanical stimulus	GO:0071260
Extrinsic apoptotic signaling pathway	GO:0097191

Publications from PubMed Top Help

Type 1 Diabetes Publications: 8

Publications: 693

De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF.
Mahul-Mellier AL, Pazarentzos E, Datler C, Iwasawa R, Abuali G, Lin B, Grimm S
Cell Death Differ. 2011
PubMed ID: 22179575
Caspase 8 inhibits programmed necrosis by processing CYLD.
O'Donnell MA, Perez-Jimenez E, Oberst A, Ng A, Massoumi R, Xavier R, Green DR, Ting AT
Nat Cell Biol. 2011
PubMed ID: 22037414
Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy.
Li D, Liu Y, Maruyama M, Zhu W, Chen H, Zhang W, Reuter S, Lin SF, Haneline LS, Field LJ, Chen PS, Shou W
Hum Mol Genet. 2011
PubMed ID: 21880664
Caspase-8, c-FLIP, and caspase-9 in c-Myc-induced apoptosis of fibroblasts.
Järvinen K, Hotti A, Santos L, Nummela P, Hölttä E
Exp Cell Res. 2011
PubMed ID: 21903094
Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice.
Bohgaki T, Mozo J, Salmena L, Matysiak-Zablocki E, Bohgaki M, Sanchez O, Strasser A, Hakem A, Hakem R
J Cell Biol. 2011
PubMed ID: 22006951
Human cell-death-inducing DFF45-like effector C induces apoptosis via caspase-8.
Tang X, Xing Z, Tang H, Liang L, Zhao M
Acta Biochim Biophys Sin (Shanghai). 2011
PubMed ID: 21865223
Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival.
Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC
Mol Cell Biol. 2011
PubMed ID: 21791606
Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release.
Li Q, Li Y, Wang X, Fang X, He K, Guo X, Zhan Z, Sun C, Jin YH
Mol Carcinog. 2011
PubMed ID: 21751259
Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkin's lymphoma in Chinese patients.
Xiao MS, Zhang DF, Zeng Y, Cheng YF, Yao YG
Ann Hematol. 2011
PubMed ID: 21633787
Guanylate cyclase activator YC-1 enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells via activation of apoptosis-related proteins.
Lee CS, Kim YJ, Kim W, Myung SC
Basic Clin Pharmacol Toxicol. 2011
PubMed ID: 21554547
Evaluation of the effects of the flavonoid apigenin on apoptotic pathway gene expression on the colon cancer cell line (HT29).
Turktekin M, Konac E, Onen HI, Alp E, Yilmaz A, Menevse S
J Med Food. 2011
PubMed ID: 21548803
Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation.
Sears N, Sen GC, Stark GR, Chattopadhyay S
J Biol Chem. 2011
PubMed ID: 21816816
Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.
Günther C, Martini E, Wittkopf N, Amann K, Weigmann B, Neumann H, Waldner MJ, Hedrick SM, Tenzer S, Neurath MF, Becker C
Nature. 2011
PubMed ID: 21921917
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
[Effects of Mycobacterium tuberculosis on apoptosis of mouse dendritic cells and activation of caspase-3, caspase-8].
Zhu FJ, Yiao YW, Xu SL, Ye WQ, Cai YJ
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011
PubMed ID: 21984154
The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells.
Wang K, Tang Y, Sun M, Lu B, Zhu H, Ji O, Shen Q
Acta Biochim Biophys Sin (Shanghai). 2011
PubMed ID: 21785112
Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis.
Irrinki KM, Mallilankaraman K, Thapa RJ, Chandramoorthy HC, Smith FJ, Jog NR, Gandhirajan RK, Kelsen SG, Houser SR, May MJ, Balachandran S, Madesh M
Mol Cell Biol. 2011
PubMed ID: 21746883
Polymorphisms in the CASP8 gene and the risk of epithelial ovarian cancer.
Ma X, Zhang J, Liu S, Huang Y, Chen B, Wang D
Gynecol Oncol. 2011
PubMed ID: 21714991
The ribonucleotide reductase R1 subunits of herpes simplex virus 1 and 2 protect cells against poly(I · C)-induced apoptosis.
Dufour F, Bertrand L, Pearson A, Grandvaux N, Langelier Y
J Virol. 2011
PubMed ID: 21697465
Low doses of the novel caspase-inhibitor GS-9450 leads to lower caspase-3 and -8 expression on peripheral CD4+ and CD8+ T-cells.
Arends JE, Hoepelman AI, Nanlohy NM, Höppener FJ, Hirsch KR, Park JG, van Baarle D
Apoptosis. 2011
PubMed ID: 21667042
Polymorphisms of caspase 8 and caspase 9 gene and colorectal cancer susceptibility and prognosis.
Theodoropoulos GE, Gazouli M, Vaiopoulou A, Leandrou M, Nikouli S, Vassou E, Kouraklis G, Nikiteas N
Int J Colorectal Dis. 2011
PubMed ID: 21538054
In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells.
Chauhan D, Tian Z, Zhou B, Kuhn D, Orlowski R, Raje N, Richardson P, Anderson KC
Clin Cancer Res. 2011
PubMed ID: 21724551
Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion.
Fauconnier J, Meli AC, Thireau J, Roberge S, Shan J, Sassi Y, Reiken SR, Rauzier JM, Marchand A, Chauvier D, Cassan C, Crozier C, Bideaux P, Lompré AM, Jacotot E, Marks AR, Lacampagne A
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21788490
The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.
Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F, Zachariou A, Lopez J, MacFarlane M, Cain K, Meier P
Mol Cell. 2011
PubMed ID: 21737329
Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes.
Pan JA, Ullman E, Dou Z, Zong WX
Mol Cell Biol. 2011
PubMed ID: 21628531
Delayed caspase-8 activation and enhanced integrin β1-activated FAK underpins anoikis in oesophageal carcinoma cells harbouring mt p53-R175H.
Fanucchi S, Veale RB
Cell Biol Int. 2011
PubMed ID: 21426305
Sam68 is required for both NF-κB activation and apoptosis signaling by the TNF receptor.
Ramakrishnan P, Baltimore D
Mol Cell. 2011
PubMed ID: 21620750
Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury.
Ullman E, Pan JA, Zong WX
Mol Cell Biol. 2011
PubMed ID: 21576355
Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines.
Jang ER, Kim YJ, Myung SC, Kim W, Lee CS
Mol Cell Biochem. 2011
PubMed ID: 21380726
Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling.
Akagi T, Shimizu K, Takahama S, Iwasaki T, Sakamaki K, Endo Y, Sawasaki T
FEBS Lett. 2011
PubMed ID: 21524651
TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8.
Ikner A, Ashkenazi A
J Biol Chem. 2011
PubMed ID: 21525013
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi.
Lu Y, Zhang BY, Jia ZX, Wu WJ, Lu ZQ
Hepatobiliary Pancreat Dis Int. 2011
PubMed ID: 21669575
Cytotoxic T lymphocyte perforin and Fas ligand working in concert even when Fas ligand lytic action is still not detectable.
Hassin D, Garber OG, Meiraz A, Schiffenbauer YS, Berke G
Immunology. 2011
PubMed ID: 21517838
Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.
Li H, Wang P, Sun Q, Ding WX, Yin XM, Sobol RW, Stolz DB, Yu J, Zhang L
Cancer Res. 2011
PubMed ID: 21444671
Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex.
Kavuri SM, Geserick P, Berg D, Dimitrova DP, Feoktistova M, Siegmund D, Gollnick H, Neumann M, Wajant H, Leverkus M
J Biol Chem. 2011
PubMed ID: 21454681
Caspase signalling controls microglia activation and neurotoxicity.
Burguillos MA, Deierborg T, Kavanagh E, Persson A, Hajji N, Garcia-Quintanilla A, Cano J, Brundin P, Englund E, Venero JL, Joseph B
Nature. 2011
PubMed ID: 21389984
Apoptosis in the sequestrated nucleus pulposus compared to the remaining nucleus pulposus in the same patient.
Ha KY, Kim BG, Kim KW, Oh IS, Seo JY
Spine (Phila Pa 1976). 2011
PubMed ID: 21178828
In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8.
Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J, Vaux DL
J Biol Chem. 2011
PubMed ID: 21339290
Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis.
Duiker EW, Meijer A, van der Bilt AR, Meersma GJ, Kooi N, van der Zee AG, de Vries EG, de Jong S
Br J Cancer. 2011
PubMed ID: 21487429
Mechanisms of necroptosis in T cells.
Ch'en IL, Tsau JS, Molkentin JD, Komatsu M, Hedrick SM
J Exp Med. 2011
PubMed ID: 21402742
Changes in activities of caspase-8 and caspase-9 in human cervical malignancy.
Ekonomopoulou MT, Babas E, Mioglou-Kalouptsi E, Malandri M, Iakovidou-Kritsi Z
Int J Gynecol Cancer. 2011
PubMed ID: 21436691
CASP8 promoter polymorphism is associated with high-risk HPV types and abnormal cytology but not with cervical cancer.
Chatterjee K, Williamson AL, Hoffman M, Dandara C
J Med Virol. 2011
PubMed ID: 21328377
TRAIL-induced keratinocyte differentiation requires caspase activation and p63 expression.
Wu NL, Lee TA, Tsai TL, Lin WW
J Invest Dermatol. 2011
PubMed ID: 21248767
RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein.
Rajput A, Kovalenko A, Bogdanov K, Yang SH, Kang TB, Kim JC, Du J, Wallach D
Immunity. 2011
PubMed ID: 21419663
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR
Nature. 2011
PubMed ID: 21368763
RIP3 mediates the embryonic lethality of caspase-8-deficient mice.
Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer LP, Hakem R, Caspary T, Mocarski ES
Nature. 2011
PubMed ID: 21368762
Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability.
Peng C, Cho YY, Zhu F, Zhang J, Wen W, Xu Y, Yao K, Ma WY, Bode AM, Dong Z
J Biol Chem. 2011
PubMed ID: 21183680
The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFα- and FasL-induced apoptosis by interacting with caspase-8.
Dufour F, Sasseville AM, Chabaud S, Massie B, Siegel RM, Langelier Y
Apoptosis. 2011
PubMed ID: 21107701
Hypermethylation of apoptotic genes as independent prognostic factor in neuroblastoma disease.
Grau E, Martinez F, Orellana C, Canete A, Yañez Y, Oltra S, Noguera R, Hernandez M, Bermúdez JD, Castel V
Mol Carcinog. 2011
PubMed ID: 21104989
BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane.
Schug ZT, Gonzalvez F, Houtkooper RH, Vaz FM, Gottlieb E
Cell Death Differ. 2011
PubMed ID: 21072056
Peroxiredoxin 6 interferes with TRAIL-induced death-inducing signaling complex formation by binding to death effector domain caspase.
Choi H, Chang JW, Jung YK
Cell Death Differ. 2011
PubMed ID: 20829884
The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas.
Knox PG, Davies CC, Ioannou M, Eliopoulos AG
J Cell Biol. 2011
PubMed ID: 21282461
Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes.
Edelmann B, Bertsch U, Tchikov V, Winoto-Morbach S, Perrotta C, Jakob M, Adam-Klages S, Kabelitz D, Schütze S
EMBO J. 2011
PubMed ID: 21157428
Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity.
Krajewska M, You Z, Rong J, Kress C, Huang X, Yang J, Kyoda T, Leyva R, Banares S, Hu Y, Sze CH, Whalen MJ, Salmena L, Hakem R, Head BP, Reed JC, Krajewski S
PLoS One. 2011
PubMed ID: 21957448
Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells.
Liu J, Uematsu H, Tsuchida N, Ikeda MA
Mol Cancer. 2011
PubMed ID: 21801448
Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways.
Green JA, Dholakia S, Janczar K, Ong CW, Moores R, Fry J, Elkington PT, Roncaroli F, Friedland JS
J Neuroinflammation. 2011
PubMed ID: 21569377
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Silibinin-induced apoptosis in MCF7 and T47D human breast carcinoma cells involves caspase-8 activation and mitochondrial pathway.
Tiwari P, Kumar A, Balakrishnan S, Kushwaha HS, Mishra KP
Cancer Invest. 2011
PubMed ID: 21166494
Compartmentalization of TNF-receptor 1 signaling: TNF-R1-associated caspase-8 mediates activation of acid sphingomyelinase in late endosomes.
Bertsch U, Edelmann B, Tchikov V, Winoto-Morbach S, Schütze S
Adv Exp Med Biol. 2011
PubMed ID: 21153367
Anti-inflammatory functions of caspase-8.
Rajput A, Kang TB, Bogdanov K, Kim JC, Ben-Moshe T, Kovalenko A, Wallach D
Adv Exp Med Biol. 2011
PubMed ID: 21153328
Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.
Guicciardi ME, Mott JL, Bronk SF, Kurita S, Fingas CD, Gores GJ
Exp Cell Res. 2011
PubMed ID: 20951133
Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes.
Delfino DV, Spinicelli S, Pozzesi N, Pierangeli S, Velardi E, Bruscoli S, Martelli MP, Pettirossi V, Falchi L, Kang TB, Riccardi C
Cell Death Differ. 2011
PubMed ID: 20671745
Clustering of the neural cell adhesion molecule (NCAM) at the neuronal cell surface induces caspase-8- and -3-dependent changes of the spectrin meshwork required for NCAM-mediated neurite outgrowth.
Westphal D, Sytnyk V, Schachner M, Leshchyns'ka I
J Biol Chem. 2010
PubMed ID: 20961848
Activation of caspase-9, but not caspase-2 or caspase-8, is essential for heat-induced apoptosis in Jurkat cells.
Shelton SN, Dillard CD, Robertson JD
J Biol Chem. 2010
PubMed ID: 20978129
Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8.
Li C, Lasse S, Lee P, Nakasaki M, Chen SW, Yamasaki K, Gallo RL, Jamora C
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21135236
Investigation of genetic susceptibility factors for human longevity - A targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A
Mutat Res. 2010
PubMed ID: 20800603
Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity.
Matthess Y, Raab M, Sanhaji M, Lavrik IN, Strebhardt K
Mol Cell Biol. 2010
PubMed ID: 20937773
MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X
Carcinogenesis. 2010
PubMed ID: 20819778
Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation.
Won M, Park KA, Byun HS, Sohn KC, Kim YR, Jeon J, Hong JH, Park J, Seok JH, Kim JM, Yoon WH, Jang IS, Shen HM, Liu ZG, Hur GM
Cell Death Differ. 2010
PubMed ID: 20448643
Polymorphism in tumor necrosis factor-related apoptosis-inducing ligand receptor 1 is associated with poor viral response to interferon-based hepatitis C virus therapy in HIV/hepatitis C virus-coinfected individuals.
Rizza SA, Cummins NW, Rider DN, Saeed S, Klein MB, Badley AD
AIDS. 2010
PubMed ID: 20802294
Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
Association of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
Engel C, Versmold B, Wappenschmidt B, Simard J, Easton DF, Peock S, Cook M, Oliver C, Frost D, Mayes R, Evans DG, Eeles R, Paterson J, Brewer C, Epidemiological Study of Familial Breast Cancer (EMBRACE), McGuffog L, Antoniou AC, Stoppa-Lyonnet D, Sinilnikova OM, Barjhoux L, Frenay M, Michel C, Leroux D, Dreyfus H, Toulas C, Gladieff L, Uhrhammer N, Bignon YJ, Meindl A, Arnold N, Varon-Mateeva R, Niederacher D, Preisler-Adams S, Kast K, Deissler H, Sutter C, Gadzicki D, Chenevix-Trench G, Spurdle AB, Chen X, Beesley J, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Olsson H, Kristoffersson U, Ehrencrona H, Liljegren A, Swedish Breast Cancer Study, Sweden (SWE-BRCA), van der Luijt RB, van Os TA, van Leeuwen FE, Hereditary Breast and Ovarian cancer group Netherlands (HEBON), Domchek SM, Rebbeck TR, Nathanson KL, Osorio A, Ramón y Cajal T, Konstantopoulou I, Benítez J, Friedman E, Kaufman B, Laitman Y, Mai PL, Greene MH, Nevanlinna H, Aittomäki K, Szabo CI, Caldes T, Couch FJ, Andrulis IL, Godwin AK, Hamann U, Schmutzler RK, Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20978178
The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia.
Kim DH, Kong JH, Byeun JY, Jung CW, Xu W, Liu X, Kamel-Reid S, Kim YK, Kim HJ, Lipton JH
Clin Cancer Res. 2010
PubMed ID: 20959405
Caspase activation is not required for villous cytotrophoblast fusion into syncytiotrophoblasts.
Guilbert LJ, Riddell M, Winkler-Lowen B
Placenta. 2010
PubMed ID: 20870287
Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.
Kelly JL, Novak AJ, Fredericksen ZS, Liebow M, Ansell SM, Dogan A, Wang AH, Witzig TE, Call TG, Kay NE, Habermann TM, Slager SL, Cerhan JR
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20855536
Modulation of RIP1 ubiquitylation and distribution by MeBS to sensitize cancer cells to tumor necrosis factor α-induced apoptosis.
Kim S, Ohoka N, Okuhira K, Sai K, Nishimaki-Mogami T, Naito M
Cancer Sci. 2010
PubMed ID: 20825417
A previously unreported function of β(1)B integrin isoform in caspase-8-dependent integrin-mediated keratinocyte death.
Lotti R, Marconi A, Truzzi F, Dallaglio K, Gemelli C, Borroni RG, Palazzo E, Pincelli C
J Invest Dermatol. 2010
PubMed ID: 20613771
The small heat shock protein HspB2 is a novel anti-apoptotic protein that inhibits apical caspase activation in the extrinsic apoptotic pathway.
Oshita SE, Chen F, Kwan T, Yehiely F, Cryns VL
Breast Cancer Res Treat. 2010
PubMed ID: 20087649
Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition.
Leong SM, Tan BX, Bte Ahmad B, Yan T, Chee LY, Ang ST, Tay KG, Koh LP, Yeoh AE, Koay ES, Mok YK, Lim TM
Blood. 2010
PubMed ID: 20606168
The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling.
Würstle ML, Laussmann MA, Rehm M
J Biol Chem. 2010
PubMed ID: 20702410
N-acetylcysteine counteracts oxidative stress and prevents hCG-induced apoptosis in rat Leydig cells through down regulation of caspase-8 and JNK.
Aggarwal A, Misro MM, Maheshwari A, Sehgal N, Nandan D
Mol Reprod Dev. 2010
PubMed ID: 20824644
Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines.
Van Geelen CM, Pennarun B, Ek WB, Le PT, Spierings DC, De Vries EG, De Jong S
Int J Oncol. 2010
PubMed ID: 20811726
Autophagic degradation of active caspase-8: a crosstalk mechanism between autophagy and apoptosis.
Hou W, Han J, Lu C, Goldstein LA, Rabinowich H
Autophagy. 2010
PubMed ID: 20724831
An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K
Hum Genet. 2010
PubMed ID: 20677014
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Functional polymorphisms in cell death pathway genes and risk of renal cell carcinoma.
Zhu J, Qin C, Wang M, Yan F, Ju X, Meng X, Ding Q, Li P, Yang J, Cao Q, Zhang Z, Yin C
Mol Carcinog. 2010
PubMed ID: 20572163
Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation.
Ehrenschwender M, Siegmund D, Wicovsky A, Kracht M, Dittrich-Breiholz O, Spindler V, Waschke J, Kalthoff H, Trauzold A, Wajant H
Cell Death Differ. 2010
PubMed ID: 20379197
Regulation of mRNA caspase-8 levels by anti-nuclear autoantibodies.
Lisi S, Sisto M, Lofrumento D, Frassanito MA, Caprio S, Romano ML, Mitolo V, D'Amore M
Clin Exp Med. 2010
PubMed ID: 20033750
Influence of caspases 8 and 9 gene promoter polymorphism on prostate cancer susceptibility and early development of hormone refractory prostate cancer.
Kesarwani P, Mandal RK, Maheshwari R, Mittal RD
BJU Int. 2010
PubMed ID: 20804486
Intracellular Casp8p41 content is inversely associated with CD4 T cell count.
Cummins NW, Jiang W, McGinty J, Bren GD, Bosch RJ, Landay A, Deeks SG, Martin JN, Douek D, Lederman MM, Brenchley J, Badley AD
J Infect Dis. 2010
PubMed ID: 20565257
Expression and prognostic significance of APAF-1, caspase-8 and caspase-9 in stage II/III colon carcinoma: caspase-8 and caspase-9 is associated with poor prognosis.
Sträter J, Herter I, Merkel G, Hinz U, Weitz J, Möller P
Int J Cancer. 2010
PubMed ID: 20013803
Polymorphisms in the caspase genes and the risk of lung cancer.
Lee SY, Choi YY, Choi JE, Kim MJ, Kim JS, Jung DK, Kang HG, Jeon HS, Lee WK, Jin G, Cha SI, Kim CH, Jung TH, Park JY
J Thorac Oncol. 2010
PubMed ID: 20661084
14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway.
Roy DN, Mandal S, Sen G, Mukhopadhyay S, Biswas T
Br J Pharmacol. 2010
PubMed ID: 20649583
FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women.
Barnholtz-Sloan JS, Shetty PB, Guan X, Nyante SJ, Luo J, Brennan DJ, Millikan RC
Carcinogenesis. 2010
PubMed ID: 20554749
The CASP8 rs3834129 polymorphism and breast cancer risk in BRCA1 mutation carriers.
Catucci I, Verderio P, Pizzamiglio S, Manoukian S, Peissel B, Zaffaroni D, Roversi G, Ripamonti CB, Pasini B, Barile M, Viel A, Giannini G, Papi L, Varesco L, Martayan A, Riboni M, Volorio S, Radice P, Peterlongo P
Breast Cancer Res Treat. 2010
PubMed ID: 20652397
A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.
Ho-Pun-Cheung A, Assenat E, Bascoul-Mollevi C, Bibeau F, Boissière-Michot F, Thezenas S, Cellier D, Azria D, Rouanet P, Senesse P, Ychou M, Lopez-Crapez E
Pharmacogenomics J. 2010
PubMed ID: 20644561
Single-cell analysis of dihydroartemisinin-induced apoptosis through reactive oxygen species-mediated caspase-8 activation and mitochondrial pathway in ASTC-a-1 cells using fluorescence imaging techniques.
Lu YY, Chen TS, Wang XP, Li L
J Biomed Opt. 2010
PubMed ID: 20799830
Caspase-8 polymorphisms and risk of gallbladder cancer in a northern Indian population.
Srivastava K, Srivastava A, Mittal B
Mol Carcinog. 2010
PubMed ID: 20564345
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
Caspases-2 and -8 are involved in the presenilin1/gamma-secretase-dependent cleavage of amyloid precursor protein after the induction of apoptosis.
Chae SS, Yoo CB, Jo C, Yun SM, Jo SA, Koh YH
J Neurosci Res. 2010
PubMed ID: 20143425
Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.
Travis RC, Reeves GK, Green J, Bull D, Tipper SJ, Baker K, Beral V, Peto R, Bell J, Zelenika D, Lathrop M, Million Women Study Collaborators
Lancet. 2010
PubMed ID: 20605201
DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DR5 and caspase-8.
Kurita S, Higuchi H, Saito Y, Nakamoto N, Takaishi H, Tada S, Saito H, Gores GJ, Hibi T
Cancer Sci. 2010
PubMed ID: 20398055
DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas.
Bellail AC, Tse MC, Song JH, Phuphanich S, Olson JJ, Sun SY, Hao C
J Cell Mol Med. 2010
PubMed ID: 19432816
Protein kinase RNA/FADD/caspase-8 pathway mediates the proapoptotic activity of the RNA-binding protein human antigen R (HuR).
von Roretz C, Gallouzi IE
J Biol Chem. 2010
PubMed ID: 20353946
Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.
Oberst A, Pop C, Tremblay AG, Blais V, Denault JB, Salvesen GS, Green DR
J Biol Chem. 2010
PubMed ID: 20308068
Breast cancer susceptibility variants alter risk in familial ovarian cancer.
Latif A, McBurney HJ, Roberts SA, Lalloo F, Howell A, Evans DG, Newman WG
Fam Cancer. 2010
PubMed ID: 20502973
TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.
Bettermann K, Vucur M, Haybaeck J, Koppe C, Janssen J, Heymann F, Weber A, Weiskirchen R, Liedtke C, Gassler N, Müller M, de Vos R, Wolf MJ, Boege Y, Seleznik GM, Zeller N, Erny D, Fuchs T, Zoller S, Cairo S, Buendia MA, Prinz M, Akira S, Tacke F, Heikenwalder M, Trautwein C, Luedde T
Cancer Cell. 2010
PubMed ID: 20478530
A combination of functional polymorphisms in the CASP8, MMP1, IL10 and SEPS1 genes affects risk of non-small cell lung cancer.
Hart K, Landvik NE, Lind H, Skaug V, Haugen A, Zienolddiny S
Lung Cancer. 2010
PubMed ID: 20471133
Functional implication of TRAIL -716 C/T promoter polymorphism on its in vitro and in vivo expression and the susceptibility to sporadic breast tumor.
Pal R, Gochhait S, Chattopadhyay S, Gupta P, Prakash N, Agarwal G, Chaturvedi A, Husain N, Husain SA, Bamezai RN
Breast Cancer Res Treat. 2010
PubMed ID: 20443055
Activation of caspases and apoptosis in response to low-voltage electric pulses.
Matsuki N, Takeda M, Ishikawa T, Kinjo A, Hayasaka T, Imai Y, Yamaguchi T
Oncol Rep. 2010
PubMed ID: 20372860
Genetic association of CASP8 polymorphisms with primary progressive multiple sclerosis.
Camiña-Tato M, Fernández M, Morcillo-Suárez C, Navarro A, Julià E, Edo MC, Montalban X, Comabella M
J Neuroimmunol. 2010
PubMed ID: 20363033
Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation.
Hellwig CT, Ludwig-Galezowska AH, Concannon CG, Litchfield DW, Prehn JH, Rehm M
J Cell Sci. 2010
PubMed ID: 20356928
CASP8 polymorphisms contribute to cancer susceptibility: evidence from a meta-analysis of 23 publications with 55 individual studies.
Yin M, Yan J, Wei S, Wei Q
Carcinogenesis. 2010
PubMed ID: 20176653
Association of CASP8 D302H polymorphism with reduced risk of aggressive prostate carcinoma.
Lubahn J, Berndt SI, Jin CH, Klim A, Luly J, Wu WS, Isaacs S, Wiley K, Isaacs WB, Suarez BK, Hayes RB, Kibel AS
Prostate. 2010
PubMed ID: 20033885
[Effect of formaldehyde on expressions of Fas apoptosis pathway-related genes of ovary tissues in female rats].
Peng G, Zhong C, Zhang Q, Xie Y, Gong F
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010
PubMed ID: 20448356
Mutational analysis of caspase genes in prostate carcinomas.
Kim MS, Park SW, Kim YR, Lee JY, Lim HW, Song SY, Yoo NJ, Lee SH
APMIS. 2010
PubMed ID: 20402676
Targeted photodynamic therapy for prostate cancer: inducing apoptosis via activation of the caspase-8/-3 cascade pathway.
Liu T, Wu LY, Choi JK, Berkman CE
Int J Oncol. 2010
PubMed ID: 20198319
Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death.
Kumar Y, Radha V, Swarup G
Biochem J. 2010
PubMed ID: 20085538
Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer.
Pennarun B, Meijer A, de Vries EG, Kleibeuker JH, Kruyt F, de Jong S
Biochim Biophys Acta. 2010
PubMed ID: 19961901
Performance of common genetic variants in breast-cancer risk models.
Wacholder S, Hartge P, Prentice R, Garcia-Closas M, Feigelson HS, Diver WR, Thun MJ, Cox DG, Hankinson SE, Kraft P, Rosner B, Berg CD, Brinton LA, Lissowska J, Sherman ME, Chlebowski R, Kooperberg C, Jackson RD, Buckman DW, Hui P, Pfeiffer R, Jacobs KB, Thomas GD, Hoover RN, Gail MH, Chanock SJ, Hunter DJ
N Engl J Med. 2010
PubMed ID: 20237344
Epigenetic methylation and expression of caspase 8 and survivin in hepatocellular carcinoma.
Cho S, Lee JH, Cho SB, Yoon KW, Park SY, Lee WS, Park CH, Joo YE, Kim HS, Choi SK, Rew JS
Pathol Int. 2010
PubMed ID: 20403046
Expression of caspase and apoptotic signal pathway induced by sulfur dioxide.
Bai J, Meng Z
Environ Mol Mutagen. 2010
PubMed ID: 19621461
Common genetic variants associated with breast cancer and mammographic density measures that predict disease.
Odefrey F, Stone J, Gurrin LC, Byrnes GB, Apicella C, Dite GS, Cawson JN, Giles GG, Treloar SA, English DR, Hopper JL, Southey MC, Australian Twins and Sisters Mammographic Density Study
Cancer Res. 2010
PubMed ID: 20145138
The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck.
Li C, Lu J, Liu Z, Wang LE, Zhao H, El-Naggar AK, Sturgis EM, Wei Q
Cancer Prev Res (Phila Pa). 2010
PubMed ID: 20086182
Caspase 8 and human villous cytotrophoblast differentiation.
Rote NS, Wei BR, Xu C, Luo L
Placenta. 2010
PubMed ID: 20080300
The paradox of caspase 8 in human villous trophoblast fusion.
Gauster M, Huppertz B
Placenta. 2010
PubMed ID: 20044137
Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes.
Ovsyannikova IG, Dhiman N, Haralambieva IH, Vierkant RA, O'Byrne MM, Jacobson RM, Poland GA
Hum Genet. 2010
PubMed ID: 19902255
Sustained inhibition of tumor growth and prolonged survival following sequential administration of doxorubicin and zoledronic acid in a breast cancer model.
Ottewell PD, Lefley DV, Cross SS, Evans CA, Coleman RE, Holen I
Int J Cancer. 2010
PubMed ID: 19621384
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PLoS One. 2010
PubMed ID: 20877624
Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact.
Elrod HA, Fan S, Muller S, Chen GZ, Pan L, Tighiouart M, Shin DM, Khuri FR, Sun SY
PLoS One. 2010
PubMed ID: 20808443
Life-giving caspases: revealing new roles during mouse embryo preimplantation development.
Busso D, Dominguez C, Perez-Acle T, Moreno RD
Int J Dev Biol. 2010
PubMed ID: 20336607
Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation.
Wu Y, Alvarez M, Slamon DJ, Koeffler P, Vadgama JV
BMC Cancer. 2010
PubMed ID: 20132554
Nitric oxide and thioredoxin type 1 modulate the activity of caspase 8 in HepG2 cells.
Sengupta R, Billiar TR, Kagan VE, Stoyanovsky DA
Biochem Biophys Res Commun. 2010
PubMed ID: 20005201
Rab5 mediates caspase-8-promoted cell motility and metastasis.
Torres VA, Mielgo A, Barbero S, Hsiao R, Wilkins JA, Stupack DG
Mol Biol Cell. 2010
PubMed ID: 19923319
Association of selected polymorphisms of CCND1, p21, and caspase8 with colorectal cancer risk.
Liu B, Zhang Y, Jin M, Ni Q, Liang X, Ma X, Yao K, Li Q, Chen K
Mol Carcinog. 2010
PubMed ID: 19795398
Association of caspase-8 mutation with chemoresistance to cisplatin in HOC313 head and neck squamous cell carcinoma cells.
Liu J, Uematsu H, Tsuchida N, Ikeda MA
Biochem Biophys Res Commun. 2009
PubMed ID: 19852930
Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages.
Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S
J Immunol. 2009
PubMed ID: 19933859
Angiotensin type 2 receptor-mediated apoptosis of human prostate cancer cells.
Li H, Qi Y, Li C, Braseth LN, Gao Y, Shabashvili AE, Katovich MJ, Sumners C
Mol Cancer Ther. 2009
PubMed ID: 19996275
Polymorphisms in the CASPASE genes and survival in patients with early-stage non-small-cell lung cancer.
Yoo SS, Choi JE, Lee WK, Choi YY, Kam S, Kim MJ, Jeon HS, Lee EB, Kim DS, Lee MH, Kim IS, Jheon S, Park JY
J Clin Oncol. 2009
PubMed ID: 19826114
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q
Occup Environ Med. 2009
PubMed ID: 19773279
Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathways.
Huang SK, White ES, Wettlaufer SH, Grifka H, Hogaboam CM, Thannickal VJ, Horowitz JC, Peters-Golden M
FASEB J. 2009
PubMed ID: 19671668
IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation.
Li HM, Fujikura D, Harada T, Uehara J, Kawai T, Akira S, Reed JC, Iwai A, Miyazaki T
Cell Death Differ. 2009
PubMed ID: 19644511
Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis.
Chang CW, Tsai WH, Chuang WJ, Lin YS, Wu JJ, Liu CC, Tsai PJ, Lin MT
J Biol Chem. 2009
PubMed ID: 19801665
Role of caspase 8 as a determinant in trail sensitivity of neuroblastoma cell lines.
Tong H, Lu C, Yang Y, Zhang J, Zhang J
Pediatr Hematol Oncol. 2009
PubMed ID: 19954364
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Association of breast cancer susceptibility variants with risk of pancreatic cancer.
Couch FJ, Wang X, McWilliams RR, Bamlet WR, de Andrade M, Petersen GM
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19843670
FoxO3a governs early microglial proliferation and employs mitochondrial depolarization with caspase 3, 8, and 9 cleavage during oxidant induced apoptosis.
Shang YC, Chong ZZ, Hou J, Maiese K
Curr Neurovasc Res. 2009
PubMed ID: 19807657
Mind bomb 1 regulation of cFLIP interactions.
Zhang L, Gallagher PJ
Am J Physiol Cell Physiol. 2009
PubMed ID: 19710364
Alternative Fas-mediated cell death pathway is dependent on the different cleavage patterns of procaspase-8.
Li Y, Qi L, Iwao A, Kihira K, Dida F, Song Z, Azuma E, Komada Y
Mol Cell Biochem. 2009
PubMed ID: 19521670
FLASH, a proapoptotic protein involved in activation of caspase-8, is essential for 3' end processing of histone pre-mRNAs.
Yang XC, Burch BD, Yan Y, Marzluff WF, Dominski Z
Mol Cell. 2009
PubMed ID: 19854135
Ghrelin treatment protects lactotrophs from apoptosis in the pituitary of diabetic rats.
Granado M, Chowen JA, García-Cáceres C, Delgado-Rubín A, Barrios V, Castillero E, Argente J, Frago LM
Mol Cell Endocrinol. 2009
PubMed ID: 19540304
Down-regulation of c-FLIP Enhances death of cancer cells by smac mimetic compound.
Cheung HH, Mahoney DJ, Lacasse EC, Korneluk RG
Cancer Res. 2009
PubMed ID: 19773432
Green tea (-)-epigalocatechin-3-gallate inhibits KIT activity and causes caspase-dependent cell death in gastrointestinal stromal tumor including imatinib-resistant cells.
Chi HT, Vu HA, Iwasaki R, Thao le B, Hara Y, Taguchi T, Watanabe T, Sato Y
Cancer Biol Ther. 2009
PubMed ID: 19770581
Aberrant integrin activation induces p38 MAPK phosphorylation resulting in suppressed Fas-mediated apoptosis in T cells: implications for rheumatoid arthritis.
Lin YP, Su CC, Huang JY, Lin HC, Cheng YJ, Liu MF, Yang BC
Mol Immunol. 2009
PubMed ID: 19698994
Procaspase 8 overexpression in non-small-cell lung cancer promotes apoptosis induced by FLIP silencing.
Wilson TR, Redmond KM, McLaughlin KM, Crawford N, Gately K, O'Byrne K, Le-Clorrenec C, Holohan C, Fennell DA, Johnston PG, Longley DB
Cell Death Differ. 2009
PubMed ID: 19543235
Polymorphisms in cell death pathway genes are associated with altered sperm apoptosis and poor semen quality.
Ji G, Gu A, Hu F, Wang S, Liang J, Xia Y, Lu C, Song L, Fu G, Wang X
Hum Reprod. 2009
PubMed ID: 19542541
Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin.
Kim JG, Chae YS, Sohn SK, Moon JH, Ryoo HM, Bae SH, Kum Y, Jeon SW, Lim KH, Kang BM, Park IJ, Choi GS, Jun SH
Cancer Chemother Pharmacol. 2009
PubMed ID: 19219602
Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease.
Kovalenko A, Kim JC, Kang TB, Rajput A, Bogdanov K, Dittrich-Breiholz O, Kracht M, Brenner O, Wallach D
J Exp Med. 2009
PubMed ID: 19720838
Altered apoptosis of inflammatory neutrophils in MMP-9-deficient mice is due to lower expression and activity of caspase-3.
Kolaczkowska E, Koziol A, Plytycz B, Arnold B, Opdenakker G
Immunol Lett. 2009
PubMed ID: 19682497
Inhibition of human initiator caspase 8 and effector caspase 3 by cross-class inhibitory bovSERPINA3-1 and A3-3.
Herrera-Mendez CH, Becila S, Blanchet X, Pelissier P, Delourme D, Coulis G, Sentandreu MA, Boudjellal A, Bremaud L, Ouali A
FEBS Lett. 2009
PubMed ID: 19665028
Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.
Häcker S, Dittrich A, Mohr A, Schweitzer T, Rutkowski S, Krauss J, Debatin KM, Fulda S
Oncogene. 2009
PubMed ID: 19597472
Expression of caspase family and muscle- and apoptosis-specific genes during skeletal myogenesis in mouse embryo.
Ikeda T, Kanazawa T, Otsuka S, Ichii O, Hashimoto Y, Kon Y
J Vet Med Sci. 2009
PubMed ID: 19801895
[Expressions of receptor-interacting protein and caspase-8 in oral squamous cell carcinoma and oral precancerous lesions].
Shi YJ, Shen LJ, Yin C
Nan Fang Yi Ke Da Xue Xue Bao. 2009
PubMed ID: 19778795
7-(O)-Carboxymethyl daidzein conjugated to N-t-Boc-hexylenediamine: a novel compound capable of inducing cell death in epithelial ovarian cancer stem cells.
Green JM, Alvero AB, Kohen F, Mor G
Cancer Biol Ther. 2009
PubMed ID: 19738422
The JNK MAP kinase pathway contributes to the development of endotoxin-induced diaphragm caspase activation.
Supinski GS, Ji X, Callahan LA
Am J Physiol Regul Integr Comp Physiol. 2009
PubMed ID: 19605759
PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability.
Kaunisto A, Kochin V, Asaoka T, Mikhailov A, Poukkula M, Meinander A, Eriksson JE
Cell Death Differ. 2009
PubMed ID: 19343040
Caspase-8 in cancer biology and therapy.
Fulda S
Cancer Lett. 2009
PubMed ID: 19111387
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells.
Sharifi AM, Eslami H, Larijani B, Davoodi J
Neurosci Lett. 2009
PubMed ID: 19467786
Common genetic variants in candidate genes and risk of familial lymphoid malignancies.
Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR
Br J Haematol. 2009
PubMed ID: 19573080
A new C-terminal cleavage product of procaspase-8, p30, defines an alternative pathway of procaspase-8 activation.
Hoffmann JC, Pappa A, Krammer PH, Lavrik IN
Mol Cell Biol. 2009
PubMed ID: 19528225
TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism.
Wu X, Guo R, Chen P, Wang Q, Cunningham PN
Am J Physiol Renal Physiol. 2009
PubMed ID: 19420112
Association of two CASP8 polymorphisms with breast cancer risk: a meta-analysis.
Sergentanis TN, Economopoulos KP
Breast Cancer Res Treat. 2009
PubMed ID: 19629679
Breast cancer susceptibility variants alter risks in familial disease.
Latif A, Hadfield KD, Roberts SA, Shenton A, Lalloo F, Black GC, Howell A, Evans DG, Newman WG
J Med Genet. 2009
PubMed ID: 19617217
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies.
Lan Q, Morton LM, Armstrong B, Hartge P, Menashe I, Zheng T, Purdue MP, Cerhan JR, Zhang Y, Grulich A, Cozen W, Yeager M, Holford TR, Vajdic CM, Davis S, Leaderer B, Kricker A, Schenk M, Zahm SH, Chatterjee N, Chanock SJ, Rothman N, Wang SS
Blood. 2009
PubMed ID: 19414860
Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population.
Xu HL, Xu WH, Cai Q, Feng M, Long J, Zheng W, Xiang YB, Shu XO
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19531679
Caspase 9 and caspase 8 gene polymorphisms and susceptibility to bladder cancer in north Indian population.
Gangwar R, Mandhani A, Mittal RD
Ann Surg Oncol. 2009
PubMed ID: 19412632
Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway.
Inoue S, Browne G, Melino G, Cohen GM
Cell Death Differ. 2009
PubMed ID: 19325570
Detection of CpG island hypermethylation of caspase-8 in neuroblastoma using an oligonucleotide array.
Kamimatsuse A, Matsuura K, Moriya S, Fukuba I, Yamaoka H, Fukuda E, Kamei N, Hiyama K, Sueda T, Hiyama E
Pediatr Blood Cancer. 2009
PubMed ID: 19260109
Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer.
Ulybina YM, Kuligina ESh, Mitiushkina NV, Rozanov ME, Ivantsov AO, Ponomariova DN, Togo AV, Levchenko EV, Shutkin VA, Brenister SI, Devilee P, Zhivotovsky B, Hirvonen A, Imyanitov EN
Cancer Lett. 2009
PubMed ID: 19203830
Critical role for caspase-8 in epidermal growth factor signaling.
Finlay D, Howes A, Vuori K
Cancer Res. 2009
PubMed ID: 19470771
Fusion of villous trophoblast can be visualized by localizing active caspase 8.
Gauster M, Siwetz M, Huppertz B
Placenta. 2009
PubMed ID: 19345995
Mutational analysis of CASP1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 14 genes in gastrointestinal stromal tumors.
Kim YR, Kim KM, Yoo NJ, Lee SH
Hum Pathol. 2009
PubMed ID: 19269008
A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, for the MrOS Research Group
J Bone Miner Res. 2009
PubMed ID: 19453261
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling.
Jin Z, Li Y, Pitti R, Lawrence D, Pham VC, Lill JR, Ashkenazi A
Cell. 2009
PubMed ID: 19427028
Caspase-mediated cleavage of beta-catenin precedes drug-induced apoptosis in resistant cancer cells.
Senthivinayagam S, Mishra P, Paramasivam SK, Yallapragada S, Chatterjee M, Wong L, Rana A, Rana B
J Biol Chem. 2009
PubMed ID: 19289465
Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
Calvo SE, Pagliarini DJ, Mootha VK
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19372376
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ
Mol Cell Proteomics. 2009
PubMed ID: 19131326
Inhibitory effects of short hairpin RNA against caspase-8 on apoptosis of murine hepatoma Hepa1-6 cells.
Lin S, Liu X, Yin R, Kong D, Qu Y, Zhang Y
Biosci Trends. 2009
PubMed ID: 20103947
Tetrazolium violet induces apoptosis via caspases-8, -9 activation and Fas/FasL up-regulation in rat C6 glioma cells.
Cai CF, Feng L, Wang L, Kong QZ, Zhao YF
Arch Pharm Res. 2009
PubMed ID: 19407976
A breast cancer risk haplotype in the caspase-8 gene.
Shephard ND, Abo R, Rigas SH, Frank B, Lin WY, Brock IW, Shippen A, Balasubramanian SP, Reed MW, Bartram CR, Meindl A, Schmutzler RK, Engel C, Burwinkel B, Cannon-Albright LA, Allen-Brady K, Camp NJ, Cox A
Cancer Res. 2009
PubMed ID: 19318553
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter associated with risk and progression of bladder cancer.
Wang M, Zhang Z, Tian Y, Shao J, Zhang Z
Clin Cancer Res. 2009
PubMed ID: 19276244
Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation.
Capper D, Gaiser T, Hartmann C, Habel A, Mueller W, Herold-Mende C, von Deimling A, Siegelin MD
Acta Neuropathol. 2009
PubMed ID: 19214542
Caspase-8 is involved in neovascularization-promoting progenitor cell functions.
Scharner D, Rössig L, Carmona G, Chavakis E, Urbich C, Fischer A, Kang TB, Wallach D, Chiang YJ, Deribe YL, Dikic I, Zeiher AM, Dimmeler S
Arterioscler Thromb Vasc Biol. 2009
PubMed ID: 19122169
Dynamic expression of epidermal caspase 8 simulates a wound healing response.
Lee P, Lee DJ, Chan C, Chen SW, Ch'en I, Jamora C
Nature. 2009
PubMed ID: 19204729
Huntingtin promotes cell survival by preventing Pak2 cleavage.
Luo S, Rubinsztein DC
J Cell Sci. 2009
PubMed ID: 19240112
Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia.
Kim DH, Xu W, Ma C, Liu X, Siminovitch K, Messner HA, Lipton JH
Blood. 2009
PubMed ID: 19141860
Human initiator caspases trigger apoptotic and autophagic phenotypes in Saccharomyces cerevisiae.
Lisa-Santamaría P, Neiman AM, Cuesta-Marbán A, Mollinedo F, Revuelta JL, Jiménez A
Biochim Biophys Acta. 2009
PubMed ID: 19166881
TNFalpha-induced macrophage death via caspase-dependent and independent pathways.
Tran TM, Temkin V, Shi B, Pagliari L, Daniel S, Ferran C, Pope RM
Apoptosis. 2009
PubMed ID: 19152111
Retinoic acid regulates Fas-induced apoptosis in Jurkat T cells: reversal of mitogen-mediated repression of Fas DISC assembly.
Engedal N, Auberger P, Blomhoff HK
J Leukoc Biol. 2009
PubMed ID: 19112091
Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells.
Jani TS, Gobejishvili L, Hote PT, Barve AS, Joshi-Barve S, Kharebava G, Suttles J, Chen T, McClain CJ, Barve S
Cell Res. 2009
PubMed ID: 19048023
The many roles of FAS receptor signaling in the immune system.
Strasser A, Jost PJ, Nagata S
Immunity. 2009
PubMed ID: 19239902
Transforming growth factor beta1 induces apoptosis by suppressing FLICE-like inhibitory protein in DU145 prostate epithelial cells.
Yoo KS, Nastiuk KL, Krolewski JJ
Int J Cancer. 2009
PubMed ID: 19048627
CASP8 D302H polymorphism delays the age of onset of breast cancer in BRCA1 and BRCA2 carriers.
Palanca Suela S, Esteban Cardeñosa E, Barragán González E, de Juan Jiménez I, Chirivella González I, Segura Huerta A, Guillén Ponce C, Martínez de Dueñas E, Montalar Salcedo J, Castel Sánchez V, Bolufer Gilabert P, On Behalf of the Group for Assessment of Hereditary Cancer of Valencia Community
Breast Cancer Res Treat. 2009
PubMed ID: 19214744
ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development.
Oshima S, Turer EE, Callahan JA, Chai S, Advincula R, Barrera J, Shifrin N, Lee B, Yen B, Woo T, Malynn BA, Ma A
Nature. 2009
PubMed ID: 19060883
Caspase-dependent molecular mechanisms of anti-human DR5 monoclonal antibody mDRA-6 inducing apoptosis of human leukemia Jurkat cells.
Du YW, Liu GC, Wang J, Zhao YP, Li SL, Chen JG, Jiang Q, Cai J, Ma YF
Chin J Cancer. 2009
PubMed ID: 19550122
Caspase-8: a key role in the pathogenesis of diabetic embryopathy.
Zhao Z, Yang P, Eckert RL, Reece EA
Birth Defects Res B Dev Reprod Toxicol. 2009
PubMed ID: 19194987
Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways.
Jin D, Ojcius DM, Sun D, Dong H, Luo Y, Mao Y, Yan J
Infect Immun. 2009
PubMed ID: 19029301
p63 regulates the caspase-8-FLIP apoptotic pathway in epidermis.
Borrelli S, Candi E, Alotto D, Castagnoli C, Melino G, Viganò MA, Mantovani R
Cell Death Differ. 2009
PubMed ID: 18927586
Evidences for association of the CASP8 -652 6N del promoter polymorphism with age at diagnosis in familial breast cancer cases.
De Vecchi G, Verderio P, Pizzamiglio S, Manoukian S, Barile M, Fortuzzi S, Ravagnani F, Pierotti MA, Radice P, Peterlongo P
Breast Cancer Res Treat. 2009
PubMed ID: 18343995
A new caspase-8 isoform caspase-8s increased sensitivity to apoptosis in Jurkat cells.
Xu Z, Tang K, Wang M, Rao Q, Liu B, Wang J
J Biomed Biotechnol. 2009
PubMed ID: 20150972
Titanium dioxide (TiO2) nanoparticles induce JB6 cell apoptosis through activation of the caspase-8/Bid and mitochondrial pathways.
Zhao J, Bowman L, Zhang X, Vallyathan V, Young SH, Castranova V, Ding M
J Toxicol Environ Health A. 2009
PubMed ID: 20077182
The death effector domains of caspase-8 induce terminal differentiation.
Mielgo A, Torres VA, Schmid MC, Graf R, Zeitlin SG, Lee P, Shields DJ, Barbero S, Jamora C, Stupack DG
PLoS One. 2009
PubMed ID: 19924290
RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma: role for a caspase-8-dependent pathway.
Keuling AM, Felton KE, Parker AA, Akbari M, Andrew SE, Tron VA
PLoS One. 2009
PubMed ID: 19684859
Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
Smith AJ, Karpova Y, D'Agostino R, Willingham M, Kulik G
PLoS One. 2009
PubMed ID: 19593445
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with risk of coal workers' pneumoconiosis.
Ni C, Ye Y, Wang M, Qian H, Song Z, Jia X, Zhou J
J Toxicol Environ Health A. 2009
PubMed ID: 19492233
beta-arrestin2 inhibits opioid-induced breast cancer cell death through Akt and caspase-8 pathways.
Zhao M, Zhou G, Zhang Y, Chen T, Sun X, Stuart C, Hanley G, Li J, Zhang J, Yin D
Neoplasma. 2009
PubMed ID: 19239323
Methylation patterns of Rb1 and Casp-8 promoters and their impact on their expression in bladder cancer.
Malekzadeh K, Sobti RC, Nikbakht M, Shekari M, Hosseini SA, Tamandani DK, Singh SK
Cancer Invest. 2009
PubMed ID: 19160091
Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
Mavaddat N, Dunning AM, Ponder BA, Easton DF, Pharoah PD
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19124506
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.
Kaufmann T, Jost PJ, Pellegrini M, Puthalakath H, Gugasyan R, Gerondakis S, Cretney E, Smyth MJ, Silke J, Hakem R, Bouillet P, Mak TW, Dixit VM, Strasser A
Immunity. 2009
PubMed ID: 19119023
Activation by C5a of endothelial cell caspase 8 and cFLIP.
Albrecht EA, Sarma JV, Ward PA
Inflamm Res. 2009
PubMed ID: 19115040
Caspase 8 promotes peripheral localization and activation of Rab5.
Torres VA, Mielgo A, Barilà D, Anderson DH, Stupack D
J Biol Chem. 2008
PubMed ID: 18974049
Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Enjuanes A, Benavente Y, Bosch F, Martín-Guerrero I, Colomer D, Pérez-Alvarez S, Reina O, Ardanaz MT, Jares P, García-Orad A, Pujana MA, Montserrat E, de Sanjosé S, Campo E
Cancer Res. 2008
PubMed ID: 19074885
c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells.
Day TW, Huang S, Safa AR
Biochem Pharmacol. 2008
PubMed ID: 18840411
Novel cardiac apoptotic pathway: the dephosphorylation of apoptosis repressor with caspase recruitment domain by calcineurin.
Tan WQ, Wang JX, Lin ZQ, Li YR, Lin Y, Li PF
Circulation. 2008
PubMed ID: 19001025
Cardiolipin provides an essential activating platform for caspase-8 on mitochondria.
Gonzalvez F, Schug ZT, Houtkooper RH, MacKenzie ED, Brooks DG, Wanders RJ, Petit PX, Vaz FM, Gottlieb E
J Cell Biol. 2008
PubMed ID: 19001123
Inhibition of fatty-acid synthase induces caspase-8-mediated tumor cell apoptosis by up-regulating DDIT4.
Knowles LM, Yang C, Osterman A, Smith JW
J Biol Chem. 2008
PubMed ID: 18796435
Cleavage of phospholipase D1 by caspase promotes apoptosis via modulation of the p53-dependent cell death pathway.
Jang YH, Namkoong S, Kim YM, Lee SJ, Park BJ, Min DS
Cell Death Differ. 2008
PubMed ID: 18636075
Spatial differences in active caspase-8 defines its role in T-cell activation versus cell death.
Koenig A, Russell JQ, Rodgers WA, Budd RC
Cell Death Differ. 2008
PubMed ID: 18617900
A six-nucleotide deletion in the CASP8 promoter is not associated with a susceptibility to breast and prostate cancers in the Polish population.
Cybulski C, Wokołorczyk D, Gliniewicz B, Sikorski A, Górski B, Jakubowska A, Huzarski T, Byrski T, Debniak T, Gronwald J, Lubiński J, Narod SA
Breast Cancer Res Treat. 2008
PubMed ID: 18097748
FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells.
Bell BD, Leverrier S, Weist BM, Newton RH, Arechiga AF, Luhrs KA, Morrissette NS, Walsh CM
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18946037
Novel caspase-suicide proteins for tamoxifen-inducible apoptosis.
Chu Y, Senghaas N, Köster RW, Wurst W, Kühn R
Genesis. 2008
PubMed ID: 18802959
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
Bcl-2 and caspase-8 related anoikis resistance in human osteosarcoma MG-63 cells.
Lin D, Feng J, Chen W
Cell Biol Int. 2008
PubMed ID: 18675369
cFLIP regulates death receptor-mediated apoptosis in an ovarian granulosa cell line by inhibiting procaspase-8 cleavage.
Matsuda F, Inoue N, Goto Y, Maeda A, Cheng Y, Sakamaki K, Manabe N
J Reprod Dev. 2008
PubMed ID: 18603835
Time-dependent increases in protease activities for neuronal apoptosis in spinal cords of Lewis rats during development of acute experimental autoimmune encephalomyelitis.
Das A, Guyton MK, Matzelle DD, Ray SK, Banik NL
J Neurosci Res. 2008
PubMed ID: 18521931
CASP8 D302H and meningioma risk: An analysis of five case-control series.
Bethke L, Sullivan K, Webb E, Murray A, Schoemaker M, Auvinen A, Kiuru A, Salminen T, Johansen C, Christensen HC, Muir K, McKinney P, Hepworth S, Dimitropoulou P, Lophatananon A, Feychting M, Lönn S, Ahlbom A, Malmer B, Henriksson R, Swerdlow A, Houlston R
Cancer Lett. 2008
PubMed ID: 18823701
Association of polymorphisms in CASP10 and CASP8 with FEV/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics.
Smith AK, Lange LA, Ampleford EJ, Meyers DA, Bleecker ER, Howard TD
Clin Exp Allergy. 2008
PubMed ID: 18823309
Enhanced effect of IFNgamma on the induced apoptosis of neuroblastoma cells by cytotoxic drugs.
Tong HX, Lu CW, Zhang JH, Zhang JH
Pediatr Hematol Oncol. 2008
PubMed ID: 18728974
Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.
Maelfait J, Vercammen E, Janssens S, Schotte P, Haegman M, Magez S, Beyaert R
J Exp Med. 2008
PubMed ID: 18725521
Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.
Zhou H, Ye M, Dong J, Han G, Jiang X, Wu R, Zou H
J Proteome Res. 2008
PubMed ID: 18630941
Caspase-8 deficiency facilitates cellular transformation in vitro.
Krelin Y, Zhang L, Kang TB, Appel E, Kovalenko A, Wallach D
Cell Death Differ. 2008
PubMed ID: 18566604
In vitro activation of procaspase-8 by forming the cytoplasmic component of the death-inducing signaling complex (cDISC).
Roy A, Hong JH, Lee JH, Lee YT, Lee BJ, Kim KS
Mol Cells. 2008
PubMed ID: 18596409
Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice.
Kang TB, Oh GS, Scandella E, Bolinger B, Ludewig B, Kovalenko A, Wallach D
J Immunol. 2008
PubMed ID: 18684943
Estradiol protects PC12 cells against CoCl2-induced apoptosis.
Jung JY, Roh KH, Jeong YJ, Kim SH, Lee EJ, Kim MS, Oh WM, Oh HK, Kim WJ
Brain Res Bull. 2008
PubMed ID: 18598848
The paracaspase MALT1 controls caspase-8 activation during lymphocyte proliferation.
Kawadler H, Gantz MA, Riley JL, Yang X
Mol Cell. 2008
PubMed ID: 18691973
MUC1 oncoprotein blocks death receptor-mediated apoptosis by inhibiting recruitment of caspase-8.
Agata N, Ahmad R, Kawano T, Raina D, Kharbanda S, Kufe D
Cancer Res. 2008
PubMed ID: 18676836
Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner.
Tsao CH, Su HL, Lin YL, Yu HP, Kuo SM, Shen CI, Chen CW, Liao CL
J Gen Virol. 2008
PubMed ID: 18632964
Phosphorylation of murine caspase-9 by the protein kinase casein kinase 2 regulates its cleavage by caspase-8.
McDonnell MA, Abedin MJ, Melendez M, Platikanova TN, Ecklund JR, Ahmed K, Kelekar A
J Biol Chem. 2008
PubMed ID: 18467326
Consortium analysis of 7 candidate SNPs for ovarian cancer.
Ramus SJ, Vierkant RA, Johnatty SE, Pike MC, Van Den Berg DJ, Wu AH, Pearce CL, Menon U, Gentry-Maharaj A, Gayther SA, Dicioccio RA, McGuire V, Whittemore AS, Song H, Easton DF, Pharoah PD, Garcia-Closas M, Chanock S, Lissowska J, Brinton L, Terry KL, Cramer DW, Tworoger SS, Hankinson SE, Berchuck A, Moorman PG, Schildkraut JM, Cunningham JM, Liebow M, Kjaer SK, Hogdall E, Hogdall C, Blaakaer J, Ness RB, Moysich KB, Edwards RP, Carney ME, Lurie G, Goodman MT, Wang-Gohrke S, Kropp S, Chang-Claude J, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer), Webb PM, Chen X, Beesley J, Chenevix-Trench G, Goode EL, Ovarian Cancer Association Consortium
Int J Cancer. 2008
PubMed ID: 18431743
A mitochondrial protein compendium elucidates complex I disease biology.
Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK
Cell. 2008
PubMed ID: 18614015
Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function.
Scott FL, Fuchs GJ, Boyd SE, Denault JB, Hawkins CJ, Dequiedt F, Salvesen GS
J Biol Chem. 2008
PubMed ID: 18458084
Caspase-8 and its inhibitors in RCCs in vivo: the prominent role of ARC.
Heikaus S, Kempf T, Mahotka C, Gabbert HE, Ramp U
Apoptosis. 2008
PubMed ID: 18516683
FasL shedding is reduced by hypothermia in experimental stroke.
Liu L, Kim JY, Koike MA, Yoon YJ, Tang XN, Ma H, Lee H, Steinberg GK, Lee JE, Yenari MA
J Neurochem. 2008
PubMed ID: 18410517
CASP8 polymorphisms, estrogen and progesterone receptor status, and breast cancer risk.
Han S, Lee KM, Choi JY, Park SK, Lee JY, Lee JE, Noh DY, Ahn SH, Han W, Kim DH, Hong YC, Ha E, Yoo KY, Kang D
Breast Cancer Res Treat. 2008
PubMed ID: 17940865
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination.
Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J, Gillard JW, Jaquith JB, Morris SJ, Barker PA
Mol Cell. 2008
PubMed ID: 18570872
Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma.
Li C, Zhao H, Hu Z, Liu Z, Wang LE, Gershenwald JE, Prieto VG, Lee JE, Duvic M, Grimm EA, Wei Q
Hum Mutat. 2008
PubMed ID: 18563783
Apoptotic death of renal tubular cells in experimental sepsis.
Messaris E, Memos N, Chatzigianni E, Kataki A, Nikolopoulou M, Manouras A, Albanopoulos K, Konstadoulakis MM, Bramis J
Surg Infect (Larchmt). 2008
PubMed ID: 18570579
Cell-autonomous and non-cell-autonomous functions of caspase-8.
Ben Moshe T, Kang TB, Kovalenko A, Barash H, Abramovitch R, Galun E, Wallach D
Cytokine Growth Factor Rev. 2008
PubMed ID: 18555200
TNF-alpha induces two distinct caspase-8 activation pathways.
Wang L, Du F, Wang X
Cell. 2008
PubMed ID: 18485876
Functional variants in cell death pathway genes and risk of pancreatic cancer.
Yang M, Sun T, Wang L, Yu D, Zhang X, Miao X, Liu J, Zhao D, Li H, Tan W, Lin D
Clin Cancer Res. 2008
PubMed ID: 18483392
Relationship between expression of gastrin, somatostatin, Fas/FasL and caspases in large intestinal carcinoma.
Mao JD, Wu P, Yang YL, Wu J, Huang H
World J Gastroenterol. 2008
PubMed ID: 18473402
Identification of a critical tyrosine residue in caspase 8 that promotes cell migration.
Barbero S, Barilà D, Mielgo A, Stagni V, Clair K, Stupack D
J Biol Chem. 2008
PubMed ID: 18216014
TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis.
Sun H, Gong S, Carmody RJ, Hilliard A, Li L, Sun J, Kong L, Xu L, Hilliard B, Hu S, Shen H, Yang X, Chen YH
Cell. 2008
PubMed ID: 18455983
CASP8 variants D302H and -652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population.
Pittman AM, Broderick P, Sullivan K, Fielding S, Webb E, Penegar S, Tomlinson I, Houlston RS
Br J Cancer. 2008
PubMed ID: 18362937
The common D302H variant of CASP8 is associated with risk of glioma.
Bethke L, Sullivan K, Webb E, Murray A, Schoemaker M, Auvinen A, Kiuru A, Salminen T, Johansen C, Christensen HC, Muir K, McKinney P, Hepworth S, Dimitropoulou P, Lophatananon A, Feychting M, Lönn S, Ahlbom A, Malmer B, Henriksson R, Swerdlow A, Houlston R
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18398042
Caspase polymorphisms and genetic susceptibility to multiple myeloma.
Hosgood HD, Baris D, Zhang Y, Zhu Y, Zheng T, Yeager M, Welch R, Zahm S, Chanock S, Rothman N, Lan Q
Hematol Oncol. 2008
PubMed ID: 18381704
Caspases-3, -8, and -9 are required for induction of epithelial cell apoptosis by enteropathogenic E. coli but are dispensable for increased paracellular permeability.
Flynn AN, Buret AG
Microb Pathog. 2008
PubMed ID: 18054197
Caspase activation in fetal rat brain following experimental intrauterine inflammation.
Sharangpani A, Takanohashi A, Bell MJ
Brain Res. 2008
PubMed ID: 18289516
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation.
Conus S, Perozzo R, Reinheckel T, Peters C, Scapozza L, Yousefi S, Simon HU
J Exp Med. 2008
PubMed ID: 18299403
Yes and PI3K bind CD95 to signal invasion of glioblastoma.
Kleber S, Sancho-Martinez I, Wiestler B, Beisel A, Gieffers C, Hill O, Thiemann M, Mueller W, Sykora J, Kuhn A, Schreglmann N, Letellier E, Zuliani C, Klussmann S, Teodorczyk M, Gröne HJ, Ganten TM, Sültmann H, Tüttenberg J, von Deimling A, Regnier-Vigouroux A, Herold-Mende C, Martin-Villalba A
Cancer Cell. 2008
PubMed ID: 18328427
Identification of apoptotic proteins in thyroid gland from patients with Graves' disease and Hashimoto's thyroiditis.
Bossowski A, Czarnocka B, Bardadin K, Stasiak-Barmuta A, Urban M, Dadan J, Ratomski K, Bossowska A
Autoimmunity. 2008
PubMed ID: 18324486
A promoter polymorphism in the CASP8 gene is not associated with cancer risk.
Haiman CA, Garcia RR, Kolonel LN, Henderson BE, Wu AH, Le Marchand L
Nat Genet. 2008
PubMed ID: 18305469
Genome-wide screening and identification of novel proteolytic cleavage targets of caspase-8 and -10 in vitro.
Bae S, Ha TS, Yoon Y, Lee J, Cha HJ, Yoo H, Choe TB, Li S, Sohn I, Kim JY, Kim CS, Jin HO, Lee HC, Park IC, Kim CS, Jin YW, Ahn SK
Int J Mol Med. 2008
PubMed ID: 18288386
Preventing hypoxia/reoxygenation damage to hepatocytes by p66(shc) ablation: up-regulation of anti-oxidant and anti-apoptotic proteins.
Haga S, Terui K, Fukai M, Oikawa Y, Irani K, Furukawa H, Todo S, Ozaki M
J Hepatol. 2008
PubMed ID: 18191273
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8.
Jia SH, Parodo J, Kapus A, Rotstein OD, Marshall JC
J Biol Chem. 2008
PubMed ID: 18086677
Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein.
Chen LH, Jiang CC, Watts R, Thorne RF, Kiejda KA, Zhang XD, Hersey P
Cancer Res. 2008
PubMed ID: 18245485
Proteasome inhibition blocks caspase-8 degradation and sensitizes prostate cancer cells to death receptor-mediated apoptosis.
Thorpe JA, Christian PA, Schwarze SR
Prostate. 2008
PubMed ID: 18076022
Expression and localization of Fas-associated proteins following focal cerebral ischemia in rats.
Bi FF, Xiao B, Hu YQ, Tian FF, Wu ZG, Ding L, Zhou XF
Brain Res. 2008
PubMed ID: 18096138
Amplification of CD95 activation by caspase 8-induced endosomal acidification in rat hepatocytes.
Reinehr R, Sommerfeld A, Keitel V, Grether-Beck S, Haüssinger D
J Biol Chem. 2008
PubMed ID: 18045865
The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.
Tapper W, Hammond V, Gerty S, Ennis S, Simmonds P, Collins A, Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) Steering Group, Eccles D
Breast Cancer Res. 2008
PubMed ID: 19094228
Clinicopathological significance of caspase-8 and caspase-10 expression in rectal cancer.
Xu B, Zhou ZG, Li Y, Wang L, Yang L, Zhou B, Liu HY, Song JM, Zeng YJ, Wang R, Shen XG, Sun XF
Oncology. 2008
PubMed ID: 18716417
Sulfur mustard induces apoptosis in cultured normal human airway epithelial cells: evidence of a dominant caspase-8-mediated pathway and differential cellular responses.
Ray R, Keyser B, Benton B, Daher A, Simbulan-Rosenthal CM, Rosenthal DS
Drug Chem Toxicol. 2008
PubMed ID: 18161513
Taurine reduces caspase-8 and caspase-9 expression induced by ischemia in the mouse hypothalamic nuclei.
Taranukhin AG, Taranukhina EY, Saransaari P, Djatchkova IM, Pelto-Huikko M, Oja SS
Amino Acids. 2008
PubMed ID: 17297564
Novel noncatalytic role for caspase-8 in promoting SRC-mediated adhesion and Erk signaling in neuroblastoma cells.
Finlay D, Vuori K
Cancer Res. 2007
PubMed ID: 18089800
Caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility.
Senft J, Helfer B, Frisch SM
Cancer Res. 2007
PubMed ID: 18089778
[Apoptosis of type II alveolar epithelial cell induced by bleomycin in lung fibrotic rat]
Kong L, Gao YQ, Wang JF, Niu JZ, Zhang XX
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007
PubMed ID: 18595259
Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma.
Kaseta MK, Gomatos IP, Khaldi L, Tzagarakis GP, Alevizos L, Themistocleous GS, Leandros E, Soucacos PN
Hybridoma (Larchmt). 2007
PubMed ID: 18158779
Caspase-8 dependent apoptosis induction in malignant myeloid cells by TLR stimulation in the presence of IFN-alpha.
Lehner M, Bailo M, Stachel D, Roesler W, Parolini O, Holter W
Leuk Res. 2007
PubMed ID: 17572490
[Effects of vascular endothelial growth factor on apoptosis of sinusoidal endothelial cells caused by ethanol: experiment with rats]
Zhang YJ, Xu L, Wang XD, Shi L, Wang ZF
Zhonghua Yi Xue Za Zhi. 2007
PubMed ID: 18269875
TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia.
Lehnardt S, Wennekamp J, Freyer D, Liedtke C, Krueger C, Nitsch R, Bechmann I, Weber JR, Henneke P
J Immunol. 2007
PubMed ID: 17947688
The apoptotic effects of oxidative stress and antiapoptotic effects of caspase inhibitors on rat notochordal cells.
Kim KW, Ha KY, Lee JS, Rhyu KW, An HS, Woo YK
Spine (Phila Pa 1976). 2007
PubMed ID: 18090083
A Fas-associated death domain protein/caspase-8-signaling axis promotes S-phase entry and maintains S6 kinase activity in T cells responding to IL-2.
Arechiga AF, Bell BD, Leverrier S, Weist BM, Porter M, Wu Z, Kanno Y, Ramos SJ, Ong ST, Siegel R, Walsh CM
J Immunol. 2007
PubMed ID: 17911615
Polymorphisms in apoptosis- and proliferation-related genes, ionizing radiation exposure, and risk of breast cancer among U.S. Radiologic Technologists.
Sigurdson AJ, Bhatti P, Doody MM, Hauptmann M, Bowen L, Simon SL, Weinstock RM, Linet MS, Rosenstein M, Stovall M, Alexander BH, Preston DL, Struewing JP, Rajaraman P
Cancer Epidemiol Biomarkers Prev. 2007
PubMed ID: 17932347
HIPK2-induced p53Ser46 phosphorylation activates the KILLER/DR5-mediated caspase-8 extrinsic apoptotic pathway.
Pistritto G, Puca R, Nardinocchi L, Sacchi A, D'Orazi G
Cell Death Differ. 2007
PubMed ID: 17627287
Catalytically active Yersinia outer protein P induces cleavage of RIP and caspase-8 at the level of the DISC independently of death receptors in dendritic cells.
Gröbner S, Adkins I, Schulz S, Richter K, Borgmann S, Wesselborg S, Ruckdeschel K, Micheau O, Autenrieth IB
Apoptosis. 2007
PubMed ID: 17624595
Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock.
Matsuda N, Takano Y, Kageyama S, Hatakeyama N, Shakunaga K, Kitajima I, Yamazaki M, Hattori Y
Cardiovasc Res. 2007
PubMed ID: 17601517
p38 MAPK and MSK1 mediate caspase-8 activation in manganese-induced mitochondria-dependent cell death.
El Mchichi B, Hadji A, Vazquez A, Leca G
Cell Death Differ. 2007
PubMed ID: 17585337
The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study.
Frank B, Rigas SH, Bermejo JL, Wiestler M, Wagner K, Hemminki K, Reed MW, Sutter C, Wappenschmidt B, Balasubramanian SP, Meindl A, Kiechle M, Bugert P, Schmutzler RK, Bartram CR, Justenhoven C, Ko YD, Brüning T, Brauch H, Hamann U, Pharoah PP, Dunning AM, Pooley KA, Easton DF, Cox A, Burwinkel B
Breast Cancer Res Treat. 2007
PubMed ID: 17891485
RbAp48 is a critical mediator controlling the transforming activity of human papillomavirus type 16 in cervical cancer.
Kong L, Yu XP, Bai XH, Zhang WF, Zhang Y, Zhao WM, Jia JH, Tang W, Zhou YB, Liu CJ
J Biol Chem. 2007
PubMed ID: 17616526
Bortezomib induces apoptosis of Epstein-Barr virus (EBV)-transformed B cells and prolongs survival of mice inoculated with EBV-transformed B cells.
Zou P, Kawada J, Pesnicak L, Cohen JI
J Virol. 2007
PubMed ID: 17626072
Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot).
Ester AR, Tyerman G, Wise CA, Blanton SH, Hecht JT
Clin Orthop Relat Res. 2007
PubMed ID: 17534194
Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice.
Prows DR, Hafertepen AP, Winterberg AV, Gibbons WJ, Liu C, Nick TG
Physiol Genomics. 2007
PubMed ID: 17488888
Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.
Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff V, Jones N
Genes Dev. 2007
PubMed ID: 17699753
Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults.
Rajaraman P, Wang SS, Rothman N, Brown MM, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Chanock SJ, Inskip PD
Cancer Epidemiol Biomarkers Prev. 2007
PubMed ID: 17684142
Interactions of HIPPI, a molecular partner of Huntingtin interacting protein HIP1, with the specific motif present at the putative promoter sequence of the caspase-1, caspase-8 and caspase-10 genes.
Majumder P, Choudhury A, Banerjee M, Lahiri A, Bhattacharyya NP
FEBS J. 2007
PubMed ID: 17623017
CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
Brown L, Ongusaha PP, Kim HG, Nuti S, Mandinova A, Lee JW, Khosravi-Far R, Aaronson SA, Lee SW
EMBO J. 2007
PubMed ID: 17599062
Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation.
Misra RS, Russell JQ, Koenig A, Hinshaw-Makepeace JA, Wen R, Wang D, Huo H, Littman DR, Ferch U, Ruland J, Thome M, Budd RC
J Biol Chem. 2007
PubMed ID: 17462996
Absence of CASP7 and CASP8 mutation in gastrointestinal lymphomas.
Yoo NJ, Soung YH, Lee SH, Kim KM, Lee SH
Eur J Haematol. 2007
PubMed ID: 17532763
Caspase inhibition reduces cardiac myocyte dyshomeostasis and improves cardiac contractile function after major burn injury.
Carlson DL, Maass DL, White J, Sikes P, Horton JW
J Appl Physiol. 2007
PubMed ID: 17431085
Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome.
Yang Q, Kiernan CM, Tian Y, Salwen HR, Chlenski A, Brumback BA, London WB, Cohn SL
Clin Cancer Res. 2007
PubMed ID: 17545522
Interferon-gamma sensitizes resistant Ewing's sarcoma cells to tumor necrosis factor apoptosis-inducing ligand-induced apoptosis by up-regulation of caspase-8 without altering chemosensitivity.
Lissat A, Vraetz T, Tsokos M, Klein R, Braun M, Koutelia N, Fisch P, Romero ME, Long L, Noellke P, Mackall CL, Niemeyer CM, Kontny U
Am J Pathol. 2007
PubMed ID: 17525260
CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme.
Martinez R, Setien F, Voelter C, Casado S, Quesada MP, Schackert G, Esteller M
Carcinogenesis. 2007
PubMed ID: 17272309
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ
Science. 2007
PubMed ID: 17525332
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers.
Sun T, Gao Y, Tan W, Ma S, Shi Y, Yao J, Guo Y, Yang M, Zhang X, Zhang Q, Zeng C, Lin D
Nat Genet. 2007
PubMed ID: 17450141
The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis.
da Silva Correia J, Miranda Y, Leonard N, Ulevitch RJ
J Biol Chem. 2007
PubMed ID: 17337451
MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells.
Mulherkar N, Prasad KV, Prabhakar BS
J Biol Chem. 2007
PubMed ID: 17314102
Role of caspase-8 in hepatocyte response to infection and injury in mice.
Ben Moshe T, Barash H, Kang TB, Kim JC, Kovalenko A, Gross E, Schuchmann M, Abramovitch R, Galun E, Wallach D
Hepatology. 2007
PubMed ID: 17385212
P60-c-src suppresses apoptosis through inhibition of caspase 8 activation in hepatoma cells, but not in primary hepatocytes.
De Toni EN, Kuntzen C, Gerbes AL, Thasler WE, Sonuc N, Mucha SR, Camaj P, Bruns C, Göke B, Eichhorst ST
J Hepatol. 2007
PubMed ID: 17224200
The extrinsic caspase pathway modulates endotoxin-induced diaphragm contractile dysfunction.
Supinski GS, Ji X, Wang W, Callahan LA
J Appl Physiol. 2007
PubMed ID: 17218430
Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma.
Lan Q, Zheng T, Chanock S, Zhang Y, Shen M, Wang SS, Berndt SI, Zahm SH, Holford TR, Leaderer B, Yeager M, Welch R, Hosgood D, Boyle P, Rothman N
Carcinogenesis. 2007
PubMed ID: 17071630
Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling.
Lemmers B, Salmena L, Bidère N, Su H, Matysiak-Zablocki E, Murakami K, Ohashi PS, Jurisicova A, Lenardo M, Hakem R, Hakem A
J Biol Chem. 2007
PubMed ID: 17213198
4- [3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) induced fas expression and activated caspase-3 and -8 in a DLD-1 colon cancer cell line.
Inoue Y, Nakayama Y, Sako T, Minagawa N, Abe Y, Nagato M, Kadowaki K, Katsuki T, Matsumoto K, Tsurudome Y, Shibao K, Hirata K, Nagata N
In Vivo. 2007
PubMed ID: 17436592
A common coding variant in CASP8 is associated with breast cancer risk.
Cox A, Dunning AM, Garcia-Closas M, Balasubramanian S, Reed MW, Pooley KA, Scollen S, Baynes C, Ponder BA, Chanock S, Lissowska J, Brinton L, Peplonska B, Southey MC, Hopper JL, McCredie MR, Giles GG, Fletcher O, Johnson N, dos Santos Silva I, Gibson L, Bojesen SE, Nordestgaard BG, Axelsson CK, Torres D, Hamann U, Justenhoven C, Brauch H, Chang-Claude J, Kropp S, Risch A, Wang-Gohrke S, Schürmann P, Bogdanova N, Dörk T, Fagerholm R, Aaltonen K, Blomqvist C, Nevanlinna H, Seal S, Renwick A, Stratton MR, Rahman N, Sangrajrang S, Hughes D, Odefrey F, Brennan P, Spurdle AB, Chenevix-Trench G, Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer, Beesley J, Mannermaa A, Hartikainen J, Kataja V, Kosma VM, Couch FJ, Olson JE, Goode EL, Broeks A, Schmidt MK, Hogervorst FB, Van't Veer LJ, Kang D, Yoo KY, Noh DY, Ahn SH, Wedrén S, Hall P, Low YL, Liu J, Milne RL, Ribas G, Gonzalez-Neira A, Benitez J, Sigurdson AJ, Stredrick DL, Alexander BH, Struewing JP, Pharoah PD, Easton DF, Breast Cancer Association Consortium
Nat Genet. 2007
PubMed ID: 17293864
Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells.
Hess F, Estrugo D, Fischer A, Belka C, Cordes N
Oncogene. 2007
PubMed ID: 16936772
Death effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanism.
Yao Z, Duan S, Hou D, Heese K, Wu M
EMBO J. 2007
PubMed ID: 17290218
Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation.
Rébé C, Cathelin S, Launay S, Filomenko R, Prévotat L, L'Ollivier C, Gyan E, Micheau O, Grant S, Dubart-Kupperschmitt A, Fontenay M, Solary E
Blood. 2007
PubMed ID: 17047155
BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms.
Mailleux AA, Overholtzer M, Schmelzle T, Bouillet P, Strasser A, Brugge JS
Dev Cell. 2007
PubMed ID: 17276340
Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress.
Chang R, Wang E
J Cell Biochem. 2007
PubMed ID: 16888816
Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization.
Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR
Nature. 2007
PubMed ID: 17108969
A novel function of caspase-8 in the regulation of androgen-receptor-driven gene expression.
Qi W, Wu H, Yang L, Boyd DD, Wang Z
EMBO J. 2007
PubMed ID: 17170703
Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling.
Feig C, Tchikov V, Schütze S, Peter ME
EMBO J. 2007
PubMed ID: 17159907
Independent induction of caspase-8 and cFLIP expression during colorectal carcinogenesis in sporadic and HNPCC adenomas and carcinomas.
Heijink DM, Kleibeuker JH, Jalving M, Boersma-van Ek W, Koornstra JJ, Wesseling J, de Jong S
Cell Oncol. 2007
PubMed ID: 17726263
TRAIL signalling: decisions between life and death.
Falschlehner C, Emmerich CH, Gerlach B, Walczak H
Int J Biochem Cell Biol. 2007
PubMed ID: 17403612
CD40L and IL-4 stimulation of acute lymphoblastic leukemia cells results in upregulation of mRNA level of FLICE--an important component of apoptosis.
łuczyński W, Kowalczuk O, Iłendo E, Stasiak-Barmuta A, Krawczuk-Rybak M, Malinowska I, Kołtan A, Szczepalński T, Olejnik I, Jaworowski R, Chyczewski L, Matysiak M, Wysocki M, Sońta-Jakimczyk D, Wieczorek M
Folia Histochem Cytobiol. 2007
PubMed ID: 17378240
Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells.
Kim EJ, Park SY, Shin HK, Kwon DY, Surh YJ, Park JH
J Nutr. 2007
PubMed ID: 17182797
Caspase function in programmed cell death.
Kumar S
Cell Death Differ. 2007
PubMed ID: 17082813
BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells.
Lagna G, Nguyen PH, Ni W, Hata A
Am J Physiol Lung Cell Mol Physiol. 2006
PubMed ID: 17030903
Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis.
Garnett TO, Filippova M, Duerksen-Hughes PJ
Cell Death Differ. 2006
PubMed ID: 16528386
Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium.
Breast Cancer Association Consortium
J Natl Cancer Inst. 2006
PubMed ID: 17018785
Identification of candidate maternal-effect genes through comparison of multiple microarray data sets.
Mager J, Schultz RM, Brunk BP, Bartolomei MS
Mamm Genome. 2006
PubMed ID: 16964442
Flavopiridol induces cellular FLICE-inhibitory protein degradation by the proteasome and promotes TRAIL-induced early signaling and apoptosis in breast tumor cells.
Palacios C, Yerbes R, López-Rivas A
Cancer Res. 2006
PubMed ID: 16951203
Polymorphisms in the caspase-8 gene and the risk of lung cancer.
Son JW, Kang HK, Chae MH, Choi JE, Park JM, Lee WK, Kim CH, Kim DS, Kam S, Kang YM, Park JY
Cancer Genet Cytogenet. 2006
PubMed ID: 16938569
5-Aza-2'-deoxycytidine and IFN-gamma cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8.
Fulda S, Debatin KM
Oncogene. 2006
PubMed ID: 16607283
Caspase-8 levels correlate with the expression of signal transducer and activator of transcription 1 in high-grade but not lower grade neuroblastoma.
Muscat A, Hawkins C, Ashley DM
Cancer. 2006
PubMed ID: 16886176
Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells.
Carter BZ, Mak DH, Schober WD, McQueen T, Harris D, Estrov Z, Evans RL, Andreeff M
Blood. 2006
PubMed ID: 16556893
Bortezomib induces in HepG2 cells IkappaBalpha degradation mediated by caspase-8.
Calvaruso G, Giuliano M, Portanova P, De Blasio A, Vento R, Tesoriere G
Mol Cell Biochem. 2006
PubMed ID: 16733806
Opposing action of estrogen receptors alpha and beta on tumor necrosis factor-alpha gene expression and caspase-8-mediated apoptotic effects in HA22T cells.
Huang EJ, Wu CC, Lee SD, Chen JH, Liu JY, Ko JL, Lin JA, Lu MC, Chen LM, Huang CY, Kuo WW
Mol Cell Biochem. 2006
PubMed ID: 16633737
Identification of proteins cleaved downstream of caspase activation in monocytes undergoing macrophage differentiation.
Cathelin S, Rébé C, Haddaoui L, Simioni N, Verdier F, Fontenay M, Launay S, Mayeux P, Solary E
J Biol Chem. 2006
PubMed ID: 16636047
Sensitivity of prostate cells to TRAIL-induced apoptosis increases with tumor progression: DR5 and caspase 8 are key players.
Hesry V, Piquet-Pellorce C, Travert M, Donaghy L, Jégou B, Patard JJ, Guillaudeux T
Prostate. 2006
PubMed ID: 16541419
The structure of FADD and its mode of interaction with procaspase-8.
Carrington PE, Sandu C, Wei Y, Hill JM, Morisawa G, Huang T, Gavathiotis E, Wei Y, Werner MH
Mol Cell. 2006
PubMed ID: 16762833
Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression.
Cursi S, Rufini A, Stagni V, Condò I, Matafora V, Bachi A, Bonifazi AP, Coppola L, Superti-Furga G, Testi R, Barilà D
EMBO J. 2006
PubMed ID: 16619028
Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury.
Tsuruma K, Nakagawa T, Morimoto N, Minami M, Hara H, Uehara T, Nomura Y
J Biol Chem. 2006
PubMed ID: 16497673
Aryl hydrocarbon receptor modulation of tumor necrosis factor-alpha-induced apoptosis and lysosomal disruption in a hepatoma model that is caspase-8-independent.
Caruso JA, Mathieu PA, Joiakim A, Zhang H, Reiners JJ
J Biol Chem. 2006
PubMed ID: 16446372
TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaB.
He L, Wu X, Siegel R, Lipsky PE
J Biol Chem. 2006
PubMed ID: 16436380
Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA.
Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S
J Immunol. 2006
PubMed ID: 16585540
Interrelated roles for Mcl-1 and BIM in regulation of TRAIL-mediated mitochondrial apoptosis.
Han J, Goldstein LA, Gastman BR, Rabinowich H
J Biol Chem. 2006
PubMed ID: 16478725
TNF-alpha-induced impairment of mitochondrial integrity and apoptosis mediated by caspase-8 in adult ventricular myocytes.
Zhu J, Liu M, Kennedy RH, Liu SJ
Cytokine. 2006
PubMed ID: 16730193
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Role of caspase 8 as a determinant in chemosensitivity of p53-mutated head and neck squamous cell carcinoma cell lines.
Kaneda Y, Shimamoto H, Matsumura K, Arvind R, Zhang S, Sakai E, Omura K, Tsuchida N
J Med Dent Sci. 2006
PubMed ID: 16722146
Prolonged activation of ERK1,2 induces FADD-independent caspase 8 activation and cell death.
Cagnol S, Van Obberghen-Schilling E, Chambard JC
Apoptosis. 2006
PubMed ID: 16538383
C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP.
Cudrici C, Niculescu F, Jensen T, Zafranskaia E, Fosbrink M, Rus V, Shin ML, Rus H
J Immunol. 2006
PubMed ID: 16493077
Caspase-8 activation and oxidative stress are involved in the cytotoxic effect of beta-amyloid on rat brain microvascular endothelial cells.
Folin M, Baiguera S, Fioravanzo L, Conconi MT, Grandi C, Nussdorfer GG, Parnigotto PP
Int J Mol Med. 2006
PubMed ID: 16465389
Association of the CASP10 V410I variant with reduced familial breast cancer risk and interaction with the CASP8 D302H variant.
Frank B, Hemminki K, Wappenschmidt B, Meindl A, Klaes R, Schmutzler RK, Bugert P, Untch M, Bartram CR, Burwinkel B
Carcinogenesis. 2006
PubMed ID: 16251207
The role of CAP3 in CD95 signaling: new insights into the mechanism of procaspase-8 activation.
Golks A, Brenner D, Schmitz I, Watzl C, Krueger A, Krammer PH, Lavrik IN
Cell Death Differ. 2006
PubMed ID: 16179941
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.
Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M
Cell. 2006
PubMed ID: 16469705
[Expression of caspase-8 after brain injury from fluid percussion in rats]
Yang J, Wang Y, Chen XG, Peng QY, Li LB, Liu M
Fa Yi Xue Za Zhi. 2006
PubMed ID: 16524172
Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing.
Al-Mashat HA, Kandru S, Liu R, Behl Y, Desta T, Graves DT
Diabetes. 2006
PubMed ID: 16443785
Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70.
Matsumori Y, Northington FJ, Hong SM, Kayama T, Sheldon RA, Vexler ZS, Ferriero DM, Weinstein PR, Liu J
Stroke. 2006
PubMed ID: 16397188
Fas costimulation of naive CD4 T cells is controlled by NF-kappaB signaling and caspase activity.
Maksimow M, Söderström TS, Jalkanen S, Eriksson JE, Hänninen A
J Leukoc Biol. 2006
PubMed ID: 16330535
Interferon-alpha enhances TRAIL-mediated apoptosis by up-regulating caspase-8 transcription in human hepatoma cells.
Liedtke C, Gröger N, Manns MP, Trautwein C
J Hepatol. 2006
PubMed ID: 16225956
Potentiation of neuroblastoma metastasis by loss of caspase-8.
Stupack DG, Teitz T, Potter MD, Mikolon D, Houghton PJ, Kidd VJ, Lahti JM, Cheresh DA
Nature. 2006
PubMed ID: 16397500
Unique and overlapping substrate specificities of caspase-8 and caspase-10.
Fischer U, Stroh C, Schulze-Osthoff K
Oncogene. 2006
PubMed ID: 16186808
Impaired kinetics of Bax-GFP and Smac/DIABLO-GFP in caspase-8- and bid-silenced and Bcl-2 overexpressed breast cancer MCF-7 cells exposed to camptothecin.
Górka M, Lamparska-Przybysz M, Motyl T
Cell Mol Biol (Noisy-le-grand). 2006
PubMed ID: 17666167
Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma.
Lázcoz P, Muñoz J, Nistal M, Pestaña A, Encío I, Castresana JS
BMC Cancer. 2006
PubMed ID: 17064406
Caspase 8L, a novel inhibitory isoform of caspase 8, is associated with undifferentiated neuroblastoma.
Miller MA, Karacay B, Zhu X, O'Dorisio MS, Sandler AD
Apoptosis. 2006
PubMed ID: 16374545
In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis.
Tu S, McStay GP, Boucher LM, Mak T, Beere HM, Green DR
Nat Cell Biol. 2006
PubMed ID: 16362053
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
c-Flip expression and function in fetal mouse gonocytes.
Giampietri C, Petrungaro S, Klinger FG, Coluccia P, Paone A, Vivarelli E, Filippini A, De Cesaris P, De Felici M, Ziparo E
FASEB J. 2006
PubMed ID: 16263940
Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells.
Du A, Zhao B, Yin D, Zhang S, Miao J
Bioorg Med Chem Lett. 2006
PubMed ID: 16242324
Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand.
Varfolomeev E, Maecker H, Sharp D, Lawrence D, Renz M, Vucic D, Ashkenazi A
J Biol Chem. 2005
PubMed ID: 16227629
Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis.
Perl M, Chung CS, Lomas-Neira J, Rachel TM, Biffl WL, Cioffi WG, Ayala A
Am J Pathol. 2005
PubMed ID: 16314469
Apoptosis induced by a new member of saponin family is mediated through caspase-8-dependent cleavage of Bcl-2.
Zhu J, Xiong L, Yu B, Wu J
Mol Pharmacol. 2005
PubMed ID: 16183855
Fas-, caspase 8-, and caspase 3-dependent signaling regulates the activity of the aminophospholipid translocase and phosphatidylserine externalization in human erythrocytes.
Mandal D, Mazumder A, Das P, Kundu M, Basu J
J Biol Chem. 2005
PubMed ID: 16179347
Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells.
El-Mahdy MA, Zhu Q, Wang QE, Wani G, Wani AA
Int J Cancer. 2005
PubMed ID: 15906362
Silencing of caspase-8 in murine hepatocellular carcinomas is mediated via methylation of an essential promoter element.
Liedtke C, Zschemisch NH, Cohrs A, Roskams T, Borlak J, Manns MP, Trautwein C
Gastroenterology. 2005
PubMed ID: 16285959
Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8.
Shin S, Lee Y, Kim W, Ko H, Choi H, Kim K
EMBO J. 2005
PubMed ID: 16193064
Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.
Berube C, Boucher LM, Ma W, Wakeham A, Salmena L, Hakem R, Yeh WC, Mak TW, Benchimol S
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16183742
Partial correction of abnormal cardiac development in caspase-8-deficient mice by cardiomyocyte expression of p 35.
Yajima N, Yamada S, Morisaki T, Toyokuni S, Yonehara S, Sakamaki K
Transgenic Res. 2005
PubMed ID: 16245150
Activation of caspase 8 in the pituitaries of streptozotocin-induced diabetic rats: implication in increased apoptosis of lactotrophs.
Arroba AI, Frago LM, Argente J, Chowen JA
Endocrinology. 2005
PubMed ID: 15976052
In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice.
Wesche-Soldato DE, Chung CS, Lomas-Neira J, Doughty LA, Gregory SH, Ayala A
Blood. 2005
PubMed ID: 15941915
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder.
Salmena L, Hakem R
J Exp Med. 2005
PubMed ID: 16157684
Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.
Beisner DR, Ch'en IL, Kolla RV, Hoffmann A, Hedrick SM
J Immunol. 2005
PubMed ID: 16148088
Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells.
Werz O, Tretiakova I, Michel A, Ulke-Lemee A, Hörnig M, Franke L, Schneider G, Samuelsson B, Rådmark O, Steinhilber D
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16135563
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Transcriptional up-regulation and activation of initiating caspases in experimental glaucoma.
Huang W, Dobberfuhl A, Filippopoulos T, Ingelsson M, Fileta JB, Poulin NR, Grosskreutz CL
Am J Pathol. 2005
PubMed ID: 16127148
Apoptosis through targeted activation of caspase 8 ("ATTAC-mice"): novel mouse models of inducible and reversible tissue ablation.
Trujillo ME, Pajvani UB, Scherer PE
Cell Cycle. 2005
PubMed ID: 16096375
Caspase-dependent and -independent activation of acid sphingomyelinase signaling.
Rotolo JA, Zhang J, Donepudi M, Lee H, Fuks Z, Kolesnick R
J Biol Chem. 2005
PubMed ID: 15849201
Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8.
Dohrman A, Russell JQ, Cuenin S, Fortner K, Tschopp J, Budd RC
J Immunol. 2005
PubMed ID: 15972663
Axonal dynactin p150Glued transports caspase-8 to drive retrograde olfactory receptor neuron apoptosis.
Carson C, Saleh M, Fung FW, Nicholson DW, Roskams AJ
J Neurosci. 2005
PubMed ID: 15987939
Accelerated degradation of caspase-8 protein correlates with TRAIL resistance in a DLD1 human colon cancer cell line.
Zhang L, Zhu H, Teraishi F, Davis JJ, Guo W, Fan Z, Fang B
Neoplasia. 2005
PubMed ID: 16036110
Immunohistochemical detection of the apoptosis-related proteins FADD, FLICE, and FLIP in Langerhans cell histiocytosis.
Bank MI, Gudbrand C, Rengtved P, Carstensen H, Fadeel B, Henter JI, Petersen BL
J Pediatr Hematol Oncol. 2005
PubMed ID: 15956881
Selective induction of apoptosis through the FADD/caspase-8 pathway by a p53 c-terminal peptide in human pre-malignant and malignant cells.
Li Y, Mao Y, Rosal RV, Dinnen RD, Williams AC, Brandt-Rauf PW, Fine RL
Int J Cancer. 2005
PubMed ID: 15645452
Caspase-8 activity prevents type 2 cytokine responses and is required for protective T cell-mediated immunity against Trypanosoma cruzi infection.
Silva EM, Guillermo LV, Ribeiro-Gomes FL, De Meis J, Pereira RM, Wu Z, Calegari-Silva TC, Seabra SH, Lopes UG, Siegel RM, Dosreis GA, Lopes MF
J Immunol. 2005
PubMed ID: 15879131
Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis.
Sharp DA, Lawrence DA, Ashkenazi A
J Biol Chem. 2005
PubMed ID: 15760909
Caspase-8 sumoylation is associated with nuclear localization.
Besnault-Mascard L, Leprince C, Auffredou MT, Meunier B, Bourgeade MF, Camonis J, Lorenzo HK, Vazquez A
Oncogene. 2005
PubMed ID: 15782135
Caspase-9 can antagonize p53-induced apoptosis by generating a p76(Rb) truncated form of Rb.
Lemaire C, Godefroy N, Costina-Parvu I, Rincheval V, Renaud F, Trotot P, Bouleau S, Mignotte B, Vayssière JL
Oncogene. 2005
PubMed ID: 15735701
ASC-mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP.
Hasegawa M, Imamura R, Kinoshita T, Matsumoto N, Masumoto J, Inohara N, Suda T
J Biol Chem. 2005
PubMed ID: 15701651
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
Nature. 2005
PubMed ID: 15815621
Effector CD4+ T cells generate intermediate caspase activity and cleavage of caspase-8 substrates.
Misra RS, Jelley-Gibbs DM, Russell JQ, Huston G, Swain SL, Budd RC
J Immunol. 2005
PubMed ID: 15778357
Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics.
Crockett DK, Fillmore GC, Elenitoba-Johnson KS, Lim MS
Proteomics. 2005
PubMed ID: 15717329
Caspase-8L expression protects CD34+ hematopoietic progenitor cells and leukemic cells from CD95-mediated apoptosis.
Mohr A, Zwacka RM, Jarmy G, Büneker C, Schrezenmeier H, Döhner K, Beltinger C, Wiesneth M, Debatin KM, Stahnke K
Oncogene. 2005
PubMed ID: 15735742
Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy.
Gajate C, Mollinedo F
J Biol Chem. 2005
PubMed ID: 15659383
Loss of Rb-E2F repression results in caspase-8-mediated apoptosis through inactivation of focal adhesion kinase.
Lieman JH, Worley LA, Harbour JW
J Biol Chem. 2005
PubMed ID: 15640164
Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells.
Weng C, Li Y, Xu D, Shi Y, Tang H
J Biol Chem. 2005
PubMed ID: 15637055
Requirement for caspase-8 in NF-kappaB activation by antigen receptor.
Su H, Bidère N, Zheng L, Cubre A, Sakai K, Dale J, Salmena L, Hakem R, Straus S, Lenardo M
Science. 2005
PubMed ID: 15746428
Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis.
Sohn D, Schulze-Osthoff K, Jänicke RU
J Biol Chem. 2005
PubMed ID: 15611097
Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway.
Jun JI, Chung CW, Lee HJ, Pyo JO, Lee KN, Kim NS, Kim YS, Yoo HS, Lee TH, Kim E, Jung YK
Oncogene. 2005
PubMed ID: 15592525
Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas.
Soung YH, Lee JW, Kim SY, Sung YJ, Park WS, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH
Oncogene. 2005
PubMed ID: 15531912
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ
Nat Biotechnol. 2005
PubMed ID: 15592455
Association of a common variant of the CASP8 gene with reduced risk of breast cancer.
MacPherson G, Healey CS, Teare MD, Balasubramanian SP, Reed MW, Pharoah PD, Ponder BA, Meuth M, Bhattacharyya NP, Cox A
J Natl Cancer Inst. 2004
PubMed ID: 15601643
Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain.
Lotocki G, Alonso OF, Dietrich WD, Keane RW
J Neurosci. 2004
PubMed ID: 15590916
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Caspase-8 gene expression in neuroblastoma.
Casciano I, Banelli B, Croce M, De Ambrosis A, di Vinci A, Gelvi I, Pagnan G, Brignole C, Allemanni G, Ferrini S, Ponzoni M, Romani M
Ann N Y Acad Sci. 2004
PubMed ID: 15650242
Structure and function of HIV-1 auxiliary regulatory protein Vpr: novel clues to drug design.
Zhao LJ, Zhu H
Curr Drug Targets Immune Endocr Metabol Disord. 2004
PubMed ID: 15578977
Interferon-gamma sensitizes osteosarcoma cells to Fas-induced apoptosis by up-regulating Fas receptors and caspase-8.
Inaba H, Glibetic M, Buck S, Ravindranath Y, Kaplan J
Pediatr Blood Cancer. 2004
PubMed ID: 15390286
TNF-alpha in vivo stimulates apoptosis in fibroblasts through caspase-8 activation and modulates the expression of pro-apoptotic genes.
Alikhani M, Alikhani Z, Raptis M, Graves DT
J Cell Physiol. 2004
PubMed ID: 15389560
FLICE/caspase-8 activation triggers anoikis induced by beta1-integrin blockade in human keratinocytes.
Marconi A, Atzei P, Panza C, Fila C, Tiberio R, Truzzi F, Wachter T, Leverkus M, Pincelli C
J Cell Sci. 2004
PubMed ID: 15507484
The NS3 protein of hepatitis C virus induces caspase-8-mediated apoptosis independent of its protease or helicase activities.
Prikhod'ko EA, Prikhod'ko GG, Siegel RM, Thompson P, Major ME, Cohen JI
Virology. 2004
PubMed ID: 15476874
Calcium binding of ARC mediates regulation of caspase 8 and cell death.
Jo DG, Jun JI, Chang JW, Hong YM, Song S, Cho DH, Shim SM, Lee HJ, Cho C, Kim DH, Jung YK
Mol Cell Biol. 2004
PubMed ID: 15509781
Impaired apoptosis of lymphocytes derived from patient with decreased expression of caspase-8 results in Alps-like phenotype.
Grzela T, Krauze A, Grzela K, Lazarczyk M, Niderla J, Brawura-Biskupski-Samaha R, Dziunycz P, Milewski L, Korczak-Kowalska G, Kulus M
Int J Mol Med. 2004
PubMed ID: 15492869
Increased caspase activation in peripheral blood mononuclear cells of patients with Alzheimer's disease.
Tacconi S, Perri R, Balestrieri E, Grelli S, Bernardini S, Annichiarico R, Mastino A, Caltagirone C, Macchi B
Exp Neurol. 2004
PubMed ID: 15473998
Down-regulation of procaspase-8 expression by focal adhesion kinase protects HL-60 cells from TRAIL-induced apoptosis.
Tamagiku Y, Sonoda Y, Kunisawa M, Ichikawa D, Murakami Y, Aizu-Yokota E, Kasahara T
Biochem Biophys Res Commun. 2004
PubMed ID: 15369772
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes.
Biju MP, Neumann AK, Bensinger SJ, Johnson RS, Turka LA, Haase VH
Mol Cell Biol. 2004
PubMed ID: 15456877
Fas/FasL-mediated apoptosis in perinatal murine lungs.
De Paepe ME, Mao Q, Embree-Ku M, Rubin LP, Luks FI
Am J Physiol Lung Cell Mol Physiol. 2004
PubMed ID: 15355863
Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism.
Sinha SK, Chaudhary PM
J Biol Chem. 2004
PubMed ID: 15280356
Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions.
Nam YJ, Mani K, Ashton AW, Peng CF, Krishnamurthy B, Hayakawa Y, Lee P, Korsmeyer SJ, Kitsis RN
Mol Cell. 2004
PubMed ID: 15383280
Sequential caspase-2 and caspase-8 activation upstream of mitochondria during ceramideand etoposide-induced apoptosis.
Lin CF, Chen CL, Chang WT, Jan MS, Hsu LJ, Wu RH, Tang MJ, Chang WC, Lin YS
J Biol Chem. 2004
PubMed ID: 15262979
Tocotrienol-induced caspase-8 activation is unrelated to death receptor apoptotic signaling in neoplastic mammary epithelial cells.
Shah S, Sylvester PW
Exp Biol Med (Maywood). 2004
PubMed ID: 15337828
Caspase-8 serves both apoptotic and nonapoptotic roles.
Kang TB, Ben-Moshe T, Varfolomeev EE, Pewzner-Jung Y, Yogev N, Jurewicz A, Waisman A, Brenner O, Haffner R, Gustafsson E, Ramakrishnan P, Lapidot T, Wallach D
J Immunol. 2004
PubMed ID: 15322156
Deletion and aberrant CpG island methylation of Caspase 8 gene in medulloblastoma.
Gonzalez-Gomez P, Bello MJ, Inda MM, Alonso ME, Arjona D, Amiñoso C, Lopez-Marin I, de Campos JM, Sarasa JL, Castresana JS, Rey JA
Oncol Rep. 2004
PubMed ID: 15289853
Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation.
Murphy BM, Creagh EM, Martin SJ
J Biol Chem. 2004
PubMed ID: 15210716
Pseudomonas aeruginosa exotoxin A induces human mast cell apoptosis by a caspase-8 and -3-dependent mechanism.
Jenkins CE, Swiatoniowski A, Issekutz AC, Lin TJ
J Biol Chem. 2004
PubMed ID: 15205454
A caspase-8-independent signaling pathway activated by Fas ligation leads to exposure of the Bak N terminus.
Zhang L, Shimizu S, Sakamaki K, Yonehara S, Tsujimoto Y
J Biol Chem. 2004
PubMed ID: 15159409
Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death.
Chandra D, Choy G, Deng X, Bhatia B, Daniel P, Tang DG
Mol Cell Biol. 2004
PubMed ID: 15254227
TNF-alpha-mediated lysosomal permeabilization is FAN and caspase 8/Bid dependent.
Werneburg N, Guicciardi ME, Yin XM, Gores GJ
Am J Physiol Gastrointest Liver Physiol. 2004
PubMed ID: 15075251
Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes.
O'Reilly LA, Divisekera U, Newton K, Scalzo K, Kataoka T, Puthalakath H, Ito M, Huang DC, Strasser A
Cell Death Differ. 2004
PubMed ID: 15017386
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8.
Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH, Lenardo MJ
Science. 2004
PubMed ID: 15131264
Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation.
Kassis R, Larrous F, Estaquier J, Bourhy H
J Virol. 2004
PubMed ID: 15163747
RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells.
Aguzzi MS, Giampietri C, De Marchis F, Padula F, Gaeta R, Ragone G, Capogrossi MC, Facchiano A
Blood. 2004
PubMed ID: 14982875
Protein kinase B inhibits apoptosis induced by actinomycin D in ECV304 cells through phosphorylation of caspase 8.
Shim D, Kang HY, Jeon BW, Kang SS, Chang SI, Kim HY
Arch Biochem Biophys. 2004
PubMed ID: 15111130
Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons.
Choi WS, Eom DS, Han BS, Kim WK, Han BH, Choi EJ, Oh TH, Markelonis GJ, Cho JW, Oh YJ
J Biol Chem. 2004
PubMed ID: 14993216
The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1.
Ruiz-Ruiz C, Ruiz de Almodóvar C, Rodríguez A, Ortiz-Ferrón G, Redondo JM, López-Rivas A
J Biol Chem. 2004
PubMed ID: 14993214
Molecular ordering of hypoxia-induced apoptosis: critical involvement of the mitochondrial death pathway in a FADD/caspase-8 independent manner.
Weinmann M, Jendrossek V, Handrick R, Güner D, Goecke B, Belka C
Oncogene. 2004
PubMed ID: 15034549
Interleukin-15 delays human neutrophil apoptosis by intracellular events and not via extracellular factors: role of Mcl-1 and decreased activity of caspase-3 and caspase-8.
Bouchard A, Ratthé C, Girard D
J Leukoc Biol. 2004
PubMed ID: 14982947
Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling.
Lindsey JC, Lusher ME, Anderton JA, Bailey S, Gilbertson RJ, Pearson AD, Ellison DW, Clifford SC
Carcinogenesis. 2004
PubMed ID: 14688019
Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.
McDonald ER, El-Deiry WS
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15069192
Cellular FLIP long form-transgenic mice manifest a Th2 cytokine bias and enhanced allergic airway inflammation.
Wu W, Rinaldi L, Fortner KA, Russell JQ, Tschopp J, Irvin C, Budd RC
J Immunol. 2004
PubMed ID: 15067048
Effects of HIV-1 Vpr on neuroinvasion and neuropathogenesis.
Pomerantz RJ
DNA Cell Biol. 2004
PubMed ID: 15142380
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway.
Kataoka T, Tschopp J
Mol Cell Biol. 2004
PubMed ID: 15024054
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM
Cell Death Differ. 2004
PubMed ID: 14713958
Menin induces apoptosis in murine embryonic fibroblasts.
Schnepp RW, Mao H, Sykes SM, Zong WX, Silva A, La P, Hua X
J Biol Chem. 2004
PubMed ID: 14688275
Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis.
Knight MJ, Riffkin CD, Ekert PG, Ashley DM, Hawkins CJ
Mol Carcinog. 2004
PubMed ID: 14991747
Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat.
Schindler CK, Shinoda S, Simon RP, Henshall DC
Neurosci Lett. 2004
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p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils.
Alvarado-Kristensson M, Melander F, Leandersson K, Rönnstrand L, Wernstedt C, Andersson T
J Exp Med. 2004
PubMed ID: 14970175
Analysis of caspase-3, caspase-8 and caspase-9 enzymatic activities in mouse oocytes and zygotes.
Papandile A, Tyas D, O'Malley DM, Warner CM
Zygote. 2004
PubMed ID: 15214581
Induction of apoptosis in resistant glioma cells by synthetic caspase-activation.
Karlsson T, Henriksson R, Hedman H
J Neurooncol. 2004
PubMed ID: 15015772
An unappreciated role for RNA surveillance.
Hillman RT, Green RE, Brenner SE
Genome Biol. 2004
PubMed ID: 14759258
HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8.
Chen H, Chung S, Sukumar S
Mol Cell Biol. 2004
PubMed ID: 14701762
Enhancement of death-receptor induced caspase-8-activation in the death-inducing signalling complex by uncoupling of oxidative phosphorylation.
Vier J, Gerhard M, Wagner H, Häcker G
Mol Immunol. 2004
PubMed ID: 14644092
Lipopolysaccharides indirectly stimulate apoptosis and global induction of apoptotic genes in fibroblasts.
Alikhani M, Alikhani Z, He H, Liu R, Popek BI, Graves DT
J Biol Chem. 2003
PubMed ID: 14551216
Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor.
Rajpal A, Cho YA, Yelent B, Koza-Taylor PH, Li D, Chen E, Whang M, Kang C, Turi TG, Winoto A
EMBO J. 2003
PubMed ID: 14657025
Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells.
Park MT, Choi JA, Kim MJ, Um HD, Bae S, Kang CM, Cho CK, Kang S, Chung HY, Lee YS, Lee SJ
J Biol Chem. 2003
PubMed ID: 14522966
Decreased levels of CD95 and caspase-8 mRNA in multiple sclerosis patients with gadolinium-enhancing lesions on MRI.
Gomes AC, Morris M, Stawiarz L, Jönsson G, Putheti P, Bronge L, Link H, Hillert J
Neurosci Lett. 2003
PubMed ID: 14625033
Expression of Fas and Fas ligand protein and mRNA in mouse oocytes and embryos.
Kelkar RL, Dharma SJ, Nandedkar TD
Reproduction. 2003
PubMed ID: 14748698
Mechanisms of caspase activation.
Boatright KM, Salvesen GS
Curr Opin Cell Biol. 2003
PubMed ID: 14644197
Interferon-gamma differentially regulates monocyte matrix metalloproteinase-1 and -9 through tumor necrosis factor-alpha and caspase 8.
Zhou M, Zhang Y, Ardans JA, Wahl LM
J Biol Chem. 2003
PubMed ID: 12960156
Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4.
Gnesutta N, Minden A
Mol Cell Biol. 2003
PubMed ID: 14560027
Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins.
Howard PL, Chia MC, Del Rizzo S, Liu FF, Pawson T
Proc Natl Acad Sci U S A. 2003
PubMed ID: 13679576
ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation.
Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Esumi H
Oncogene. 2003
PubMed ID: 13679856
Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures.
Henshall DC, Araki T, Schindler CK, Shinoda S, Lan JQ, Simon RP
J Neurochem. 2003
PubMed ID: 12911633
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease.
Gamblin TC, Chen F, Zambrano A, Abraha A, Lagalwar S, Guillozet AL, Lu M, Fu Y, Garcia-Sierra F, LaPointe N, Miller R, Berry RW, Binder LI, Cryns VL
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12888622
Interdimer processing mechanism of procaspase-8 activation.
Chang DW, Xing Z, Capacio VL, Peter ME, Yang X
EMBO J. 2003
PubMed ID: 12912912
Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway.
Wang X, Ryter SW, Dai C, Tang ZL, Watkins SC, Yin XM, Song R, Choi AM
J Biol Chem. 2003
PubMed ID: 12754217
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.
Micheau O, Tschopp J
Cell. 2003
PubMed ID: 12887920
The human caspase-8 promoter sustains basal activity through SP1 and ETS-like transcription factors and can be up-regulated by a p53-dependent mechanism.
Liedtke C, Groger N, Manns MP, Trautwein C
J Biol Chem. 2003
PubMed ID: 12748179
Execution of macrophage apoptosis by Mycobacterium avium through apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase signaling and caspase 8 activation.
Bhattacharyya A, Pathak S, Basak C, Law S, Kundu M, Basu J
J Biol Chem. 2003
PubMed ID: 12724324
Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis.
Harper N, Hughes M, MacFarlane M, Cohen GM
J Biol Chem. 2003
PubMed ID: 12721308
Functional role of caspases in sphingosine-induced apoptosis in human hepatoma cells.
Chang HC, Hsu C, Hsu HK, Yang RC
IUBMB Life. 2003
PubMed ID: 14584591
Expression of short-form caspase 8 correlates with decreased sensitivity to Fas-mediated apoptosis in neuroblastoma cells.
Kisenge RR, Toyoda H, Kang J, Tanaka S, Yamamoto H, Azuma E, Komada Y
Cancer Sci. 2003
PubMed ID: 12841868
Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo.
Weishaupt JH, Diem R, Kermer P, Krajewski S, Reed JC, Bähr M
Neurobiol Dis. 2003
PubMed ID: 12828936
Caspase-8 expression and proteolysis in human brain after severe head injury.
Zhang X, Graham SH, Kochanek PM, Marion DW, Nathaniel PD, Watkins SC, Clark RS
FASEB J. 2003
PubMed ID: 12738800
Caspase 8-mediated cleavage of the pro-apoptotic BCL-2 family member BID in p53-dependent apoptosis.
Fischer B, Coelho D, Dufour P, Bergerat JP, Denis JM, Gueulette J, Bischoff P
Biochem Biophys Res Commun. 2003
PubMed ID: 12804595
Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex.
Ryu SW, Lee SJ, Park MY, Jun JI, Jung YK, Kim E
J Biol Chem. 2003
PubMed ID: 12702723
Caspase-1 and caspase-8 cleave and inactivate cellular parkin.
Kahns S, Kalai M, Jakobsen LD, Clark BF, Vandenabeele P, Jensen PH
J Biol Chem. 2003
PubMed ID: 12692130
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S
Oncogene. 2003
PubMed ID: 12761501
Post-translational modification of Bid has differential effects on its susceptibility to cleavage by caspase 8 or caspase 3.
Degli Esposti M, Ferry G, Masdehors P, Boutin JA, Hickman JA, Dive C
J Biol Chem. 2003
PubMed ID: 12598529
Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation.
Legler DF, Micheau O, Doucey MA, Tschopp J, Bron C
Immunity. 2003
PubMed ID: 12753742
Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis.
Lum JJ, Cohen OJ, Nie Z, Weaver JG, Gomez TS, Yao XJ, Lynch D, Pilon AA, Hawley N, Kim JE, Chen Z, Montpetit M, Sanchez-Dardon J, Cohen EA, Badley AD
J Clin Invest. 2003
PubMed ID: 12750404
The mitochondriotoxic domain of Vpr determines HIV-1 virulence.
Brenner C, Kroemer G
J Clin Invest. 2003
PubMed ID: 12750393
IL-7-regulated homeostatic maintenance of recent thymic emigrants in association with caspase-mediated cell proliferation and apoptotic cell death.
O'Neill RM, Hassan J, Reen DJ
J Immunol. 2003
PubMed ID: 12707329
Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop.
von Haefen C, Wieder T, Essmann F, Schulze-Osthoff K, Dörken B, Daniel PT
Oncogene. 2003
PubMed ID: 12700660
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity.
Salmena L, Lemmers B, Hakem A, Matysiak-Zablocki E, Murakami K, Au PY, Berry DM, Tamblyn L, Shehabeldin A, Migon E, Wakeham A, Bouchard D, Yeh WC, McGlade JC, Ohashi PS, Hakem R
Genes Dev. 2003
PubMed ID: 12654726
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol.
Breckenridge DG, Stojanovic M, Marcellus RC, Shore GC
J Cell Biol. 2003
PubMed ID: 12668660
ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis.
Masumoto J, Dowds TA, Schaner P, Chen FF, Ogura Y, Li M, Zhu L, Katsuyama T, Sagara J, Taniguchi S, Gumucio DL, Núñez G, Inohara N
Biochem Biophys Res Commun. 2003
PubMed ID: 12646168
Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation.
Hopkins-Donaldson S, Ziegler A, Kurtz S, Bigosch C, Kandioler D, Ludwig C, Zangemeister-Wittke U, Stahel R
Cell Death Differ. 2003
PubMed ID: 12700635
Perforin-dependent activation-induced cell death acts through caspase 3 but not through caspases 8 or 9.
Chen L, Woo M, Hakem R, Miller RG
Eur J Immunol. 2003
PubMed ID: 12616497
ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation.
Jimbo A, Fujita E, Kouroku Y, Ohnishi J, Inohara N, Kuida K, Sakamaki K, Yonehara S, Momoi T
Exp Cell Res. 2003
PubMed ID: 12581736
A unified model for apical caspase activation.
Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H, Pedersen IM, Ricci JE, Edris WA, Sutherlin DP, Green DR, Salvesen GS
Mol Cell. 2003
PubMed ID: 12620239
Enhancement of TNF-alpha-mediated cell death in vascular smooth muscle cells through cytochrome c-independent pathway by the proteasome inhibitor.
Kim HH, Kim K
FEBS Lett. 2003
PubMed ID: 12560102
DEDD and DEDD2 associate with caspase-8/10 and signal cell death.
Alcivar A, Hu S, Tang J, Yang X
Oncogene. 2003
PubMed ID: 12527898
Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation.
Marchetti MC, Di Marco B, Cifone G, Migliorati G, Riccardi C
Blood. 2003
PubMed ID: 12393559
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
LIGHT, a member of the tumor necrosis factor ligand superfamily, prevents tumor necrosis factor-alpha-mediated human primary hepatocyte apoptosis, but not Fas-mediated apoptosis.
Matsui H, Hikichi Y, Tsuji I, Yamada T, Shintani Y
J Biol Chem. 2002
PubMed ID: 12393901
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells.
Liu JJ, Nilsson A, Oredsson S, Badmaev V, Zhao WZ, Duan RD
Carcinogenesis. 2002
PubMed ID: 12507932
In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons.
Tomioka M, Shirotani K, Iwata N, Lee HJ, Yang F, Cole GM, Seyama Y, Saido TC
Brain Res Mol Brain Res. 2002
PubMed ID: 12480175
A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis.
Chiu R, Novikov L, Mukherjee S, Shields D
J Cell Biol. 2002
PubMed ID: 12438416
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex.
Micheau O, Thome M, Schneider P, Holler N, Tschopp J, Nicholson DW, Briand C, Grütter MG
J Biol Chem. 2002
PubMed ID: 12215447
Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart.
Sakamaki K, Inoue T, Asano M, Sudo K, Kazama H, Sakagami J, Sakata S, Ozaki M, Nakamura S, Toyokuni S, Osumi N, Iwakura Y, Yonehara S
Cell Death Differ. 2002
PubMed ID: 12404118
HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation.
Nie Z, Phenix BN, Lum JJ, Alam A, Lynch DH, Beckett B, Krammer PH, Sekaly RP, Badley AD
Cell Death Differ. 2002
PubMed ID: 12404116
NF-kappa B2 p100 is a pro-apoptotic protein with anti-oncogenic function.
Wang Y, Cui H, Schroering A, Ding JL, Lane WS, McGill G, Fisher DE, Ding HF
Nat Cell Biol. 2002
PubMed ID: 12389034
Murine coronavirus-induced apoptosis in 17Cl-1 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and bid cleavage.
Chen CJ, Makino S
Virology. 2002
PubMed ID: 12441076
TRAIL receptor and CD95 signal to mitochondria via FADD, caspase-8/10, Bid, and Bax but differentially regulate events downstream from truncated Bid.
Werner AB, de Vries E, Tait SW, Bontjer I, Borst J
J Biol Chem. 2002
PubMed ID: 12196516
HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells.
Muthumani K, Hwang DS, Desai BM, Zhang D, Dayes N, Green DR, Weiner DB
J Biol Chem. 2002
PubMed ID: 12095993
Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain.
Cowling V, Downward J
Cell Death Differ. 2002
PubMed ID: 12232792
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.
Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, Siegel RM, Dale JK, Puck J, Davis J, Hall CG, Skoda-Smith S, Atkinson TP, Straus SE, Lenardo MJ
Nature. 2002
PubMed ID: 12353035
Head involution defective (Hid)-triggered apoptosis requires caspase-8 but not FADD (Fas-associated death domain) and is regulated by Erk in mammalian cells.
Varghese J, Sade H, Vandenabeele P, Sarin A
J Biol Chem. 2002
PubMed ID: 12122017
Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8.
Söderström TS, Poukkula M, Holmström TH, Heiskanen KM, Eriksson JE
J Immunol. 2002
PubMed ID: 12218097
Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen.
Thomas LR, Stillman DJ, Thorburn A
J Biol Chem. 2002
PubMed ID: 12107169
Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis.
Huang CY, Wu YM, Hsu CY, Lee WS, Lai MD, Lu TJ, Huang CL, Leu TH, Shih HM, Fang HI, Robinson DR, Kung HJ, Yuan CJ
J Biol Chem. 2002
PubMed ID: 12107159
Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2.
Benchoua A, Couriaud C, Guégan C, Tartier L, Couvert P, Friocourt G, Chelly J, Ménissier-de Murcia J, Onténiente B
J Biol Chem. 2002
PubMed ID: 12065591
Identification of a basic surface area of the FADD death effector domain critical for apoptotic signaling.
Kaufmann M, Bozic D, Briand C, Bodmer JL, Zerbe O, Kohl A, Tschopp J, Grütter MG
FEBS Lett. 2002
PubMed ID: 12220669
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.
Sprick MR, Rieser E, Stahl H, Grosse-Wilde A, Weigand MA, Walczak H
EMBO J. 2002
PubMed ID: 12198154
The FLIP variation on the TRAIL DISC: doxorubicin conducts the swan song.
Guo F, Bhalla K
Cancer Biol Ther. 2002
PubMed ID: 12496482
Doxorubicin pretreatment sensitizes prostate cancer cell lines to TRAIL induced apoptosis which correlates with the loss of c-FLIP expression.
Kelly MM, Hoel BD, Voelkel-Johnson C
Cancer Biol Ther. 2002
PubMed ID: 12496481
Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells.
Bitzer M, Armeanu S, Prinz F, Ungerechts G, Wybranietz W, Spiegel M, Bernlöhr C, Cecconi F, Gregor M, Neubert WJ, Schulze-Osthoff K, Lauer UM
J Biol Chem. 2002
PubMed ID: 12021264
Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC.
Li PF, Li J, Müller EC, Otto A, Dietz R, von Harsdorf R
Mol Cell. 2002
PubMed ID: 12191471
UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells.
Jamal S, Schneider RJ
J Clin Invest. 2002
PubMed ID: 12189238
CCR5 mediates Fas- and caspase-8 dependent apoptosis of both uninfected and HIV infected primary human CD4 T cells.
Algeciras-Schimnich A, Vlahakis SR, Villasis-Keever A, Gomez T, Heppelmann CJ, Bou G, Paya CV
AIDS. 2002
PubMed ID: 12131184
Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines.
Muthumani K, Zhang D, Hwang DS, Kudchodkar S, Dayes NS, Desai BM, Malik AS, Yang JS, Chattergoon MA, Maguire HC, Weiner DB
Oncogene. 2002
PubMed ID: 12096338
Monitoring of caspase-8/FLICE processing and activation upon Fas stimulation with novel antibodies directed against a cleavage site for caspase-8 and its substrate, FLICE-like inhibitory protein (FLIP).
Niikura Y, Nonaka T, Imajoh-Ohmi S
J Biochem. 2002
PubMed ID: 12097160
Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis.
Lagace TA, Miller JR, Ridgway ND
Mol Cell Biol. 2002
PubMed ID: 12052891
Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis.
Gukovskaya AS, Gukovsky I, Jung Y, Mouria M, Pandol SJ
J Biol Chem. 2002
PubMed ID: 11964411
An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis.
Kim Y, Suh N, Sporn M, Reed JC
J Biol Chem. 2002
PubMed ID: 11940602
Alterations of Fas-pathway genes associated with nodal metastasis in non-small cell lung cancer.
Shin MS, Kim HS, Lee SH, Lee JW, Song YH, Kim YS, Park WS, Kim SY, Lee SN, Park JY, Lee JH, Xiao W, Jo KH, Wang YP, Lee KY, Park YG, Kim SH, Lee JY, Yoo NJ
Oncogene. 2002
PubMed ID: 12037669
Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade.
Himeji D, Horiuchi T, Tsukamoto H, Hayashi K, Watanabe T, Harada M
Blood. 2002
PubMed ID: 12010809
Caspase-8 activation is necessary but not sufficient for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP.
Rokhlin OW, Guseva NV, Tagiyev AF, Glover RA, Cohen MB
Prostate. 2002
PubMed ID: 11992615
Sodium salicylate-triggered apoptosis in HL-60 cells depends on caspase-8 activation.
Chen X, Wan Y, Bai Q, Zhang W, Zhu H
Int J Hematol. 2002
PubMed ID: 12041673
Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.
Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES
J Biol Chem. 2002
PubMed ID: 11832478
The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum.
Breckenridge DG, Nguyen M, Kuppig S, Reth M, Shore GC
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11917123
Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC.
Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES
Cell Death Differ. 2002
PubMed ID: 11965497
Activation of caspase-8 is critical for sensitivity to cytotoxic anti-Fas antibody-induced apoptosis in human ovarian cancer cells.
Hayakawa A, Wu J, Kawamoto Y, Zhou YW, Tanuma S, Nakashima I, Suzuki H
Apoptosis. 2002
PubMed ID: 11865194
Nicotine preconditioning antagonizes activity-dependent caspase proteolysis of a glutamate receptor.
Meyer EL, Gahring LC, Rogers SW
J Biol Chem. 2002
PubMed ID: 11751897
Intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human multiple myeloma cells.
Mitsiades N, Mitsiades CS, Poulaki V, Anderson KC, Treon SP
Blood. 2002
PubMed ID: 11877293
Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells during pancreatitis.
Beil M, Leser J, Lutz MP, Gukovskaya A, Seufferlein T, Lynch G, Pandol SJ, Adler G
Am J Physiol Gastrointest Liver Physiol. 2002
PubMed ID: 11841995
Identification and characterization of DEDD2, a death effector domain-containing protein.
Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC
J Biol Chem. 2002
PubMed ID: 11741985
Glutathione dependence of caspase-8 activation at the death-inducing signaling complex.
Hentze H, Schmitz I, Latta M, Krueger A, Krammer PH, Wendel A
J Biol Chem. 2002
PubMed ID: 11734564
Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein.
Stegh AH, Barnhart BC, Volkland J, Algeciras-Schimnich A, Ke N, Reed JC, Peter ME
J Biol Chem. 2002
PubMed ID: 11733517
[Morphologic findings in chronic abuse of heroin and pervitine]
Toupalík P, Vanĕrková H, Klír P, Bouska I
Soud Lek. 2002
PubMed ID: 11933563
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW
Nat Cell Biol. 2002
PubMed ID: 11788820
Differential inactivation of caspase-8 in lung cancers.
Shivapurkar N, Toyooka S, Eby MT, Huang CX, Sathyanarayana UG, Cunningham HT, Reddy JL, Brambilla E, Takahashi T, Minna JD, Chaudhary PM, Gazdar AF
Cancer Biol Ther. 2002
PubMed ID: 12170765
Tumor necrosis factor-alpha-induced apoptosis in T cells from aged humans: a role of TNFR-I and downstream signaling molecules.
Gupta S
Exp Gerontol. 2002
PubMed ID: 11772515
Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function.
Garvey TL, Bertin J, Siegel RM, Wang GH, Lenardo MJ, Cohen JI
J Virol. 2002
PubMed ID: 11752160
Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease.
Viswanath V, Wu Y, Boonplueang R, Chen S, Stevenson FF, Yantiri F, Yang L, Beal MF, Andersen JK
J Neurosci. 2001
PubMed ID: 11739563
Alternative splicing of caspase-8 mRNA during differentiation of human leukocytes.
Eckhart L, Henry M, Santos-Beneit AM, Schmitz I, Krueger A, Fischer H, Bach J, Ban J, Kirchhoff S, Krammer PH, Mollinedo F, Tschachler E
Biochem Biophys Res Commun. 2001
PubMed ID: 11735112
Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53.
Bush JA, Cheung KJ, Li G
Exp Cell Res. 2001
PubMed ID: 11716543
Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8.
Kischkel FC, Lawrence DA, Tinel A, LeBlanc H, Virmani A, Schow P, Gazdar A, Blenis J, Arnott D, Ashkenazi A
J Biol Chem. 2001
PubMed ID: 11583996
Serpins and other covalent protease inhibitors.
Ye S, Goldsmith EJ
Curr Opin Struct Biol. 2001
PubMed ID: 11751056
Activation of caspase-8 in the Alzheimer's disease brain.
Rohn TT, Head E, Nesse WH, Cotman CW, Cribbs DH
Neurobiol Dis. 2001
PubMed ID: 11741396
Caspase-10 is an initiator caspase in death receptor signaling.
Wang J, Chun HJ, Wong W, Spencer DM, Lenardo MJ
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11717445
A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice.
Farmer MA, Sundberg JP, Bristol IJ, Churchill GA, Li R, Elson CO, Leiter EH
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11707574
Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation.
Saelens X, Kalai M, Vandenabeele P
J Biol Chem. 2001
PubMed ID: 11555640
Identification of a caspase-9 substrate and detection of its cleavage in programmed cell death during mouse development.
Nakanishi K, Maruyama M, Shibata T, Morishima N
J Biol Chem. 2001
PubMed ID: 11514563
Caspase-mediated cleavage of the Ca2+/calmodulin-dependent protein kinase-like kinase facilitates neuronal apoptosis.
Kruidering M, Schouten T, Evan GI, Vreugdenhil E
J Biol Chem. 2001
PubMed ID: 11479289
Differential involvement of initiator caspases in apoptotic volume decrease and potassium efflux during Fas- and UV-induced cell death.
Vu CC, Bortner CD, Cidlowski JA
J Biol Chem. 2001
PubMed ID: 11431480
C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival.
Buck M, Poli V, Hunter T, Chojkier M
Mol Cell. 2001
PubMed ID: 11684016
In vitro and in vivo transfer of bcl-2 gene into keratinocytes suppresses UVB-induced apoptosis.
Takahashi H, Honma M, Ishida-Yamamoto A, Namikawa K, Miwa A, Okado H, Kiyama H, Iizuka H
Photochem Photobiol. 2001
PubMed ID: 11683038
Serum response factor cleavage by caspases 3 and 7 linked to apoptosis in human BJAB cells.
Drewett V, Devitt A, Saxton J, Portman N, Greaney P, Cheong NE, Alnemri TF, Alnemri E, Shaw PE
J Biol Chem. 2001
PubMed ID: 11387340
The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm.
Zheng L, Schickling O, Peter ME, Lenardo MJ
J Biol Chem. 2001
PubMed ID: 11395500
Caspase-14, a keratinocyte specific caspase: mRNA splice variants and expression pattern in embryonic and adult mouse.
Kuechle MK, Predd HM, Fleckman P, Dale BA, Presland RB
Cell Death Differ. 2001
PubMed ID: 11526440
Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury.
Zhao Y, Li S, Childs EE, Kuharsky DK, Yin XM
J Biol Chem. 2001
PubMed ID: 11369777
FLASH coordinates NF-kappa B activity via TRAF2.
Choi YH, Kim KB, Kim HH, Hong GS, Kwon YK, Chung CW, Park YM, Shen ZJ, Kim BJ, Lee SY, Jung YK
J Biol Chem. 2001
PubMed ID: 11340079
[W206R]-procaspase 3: an inactivatable substrate for caspase 8.
Rank KB, Mildner AM, Leone JW, Koeplinger KA, Chou KC, Tomasselli AG, Heinrikson RL, Sharma SK
Protein Expr Purif. 2001
PubMed ID: 11437602
Fas-mediated apoptosis in neuroblastoma requires mitochondrial activation and is inhibited by FLICE inhibitor protein and Bcl-2.
Poulaki V, Mitsiades N, Romero ME, Tsokos M
Cancer Res. 2001
PubMed ID: 11406564
Exploitation of a non-apoptotic caspase to regulate the abundance of the cdkI p27(KIP1) in transformed lymphoid cells.
Frost V, Al-Mehairi S, Sinclair AJ
Oncogene. 2001
PubMed ID: 11420686
Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis.
Byun Y, Chen F, Chang R, Trivedi M, Green KJ, Cryns VL
Cell Death Differ. 2001
PubMed ID: 11423904
Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis.
Hartmann A, Troadec JD, Hunot S, Kikly K, Faucheux BA, Mouatt-Prigent A, Ruberg M, Agid Y, Hirsch EC
J Neurosci. 2001
PubMed ID: 11264300
Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex.
Xu G, Cirilli M, Huang Y, Rich RL, Myszka DG, Wu H
Nature. 2001
PubMed ID: 11260720
Pro-caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation.
Qin ZH, Wang Y, Kikly KK, Sapp E, Kegel KB, Aronin N, DiFiglia M
J Biol Chem. 2001
PubMed ID: 11102441
TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis.
Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa S, Stennicke HR, Salvesen GS, Reed JC
J Biol Chem. 2001
PubMed ID: 11098060
Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway.
Melnick M, Chen H, Zhou Y, Jaskoll T
Anat Rec. 2001
PubMed ID: 11241200
Caspase-cleaved TRAF1 negatively regulates the antiapoptotic signals of TRAF2 during TNF-induced cell death.
Jang HD, Chung YM, Baik JH, Choi YG, Park IS, Jung YK, Lee SY
Biochem Biophys Res Commun. 2001
PubMed ID: 11181075
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Stable expression of human immunodeficiency virus type 1 Nef confers resistance against Fas-mediated apoptosis.
Yoon K, Jeong JG, Kim S
AIDS Res Hum Retroviruses. 2001
PubMed ID: 11177389
Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2.
Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR
Genomics. 2001
PubMed ID: 11161814
Activation of atypical protein kinase C zeta by caspase processing and degradation by the ubiquitin-proteasome system.
Smith L, Chen L, Reyland ME, DeVries TA, Talanian RV, Omura S, Smith JB
J Biol Chem. 2000
PubMed ID: 11016947
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.
Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, Bodmer JL, Schneider P, Seed B, Tschopp J
Nat Immunol. 2000
PubMed ID: 11101870
The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity.
Siegel RM, Chan FK, Chun HJ, Lenardo MJ
Nat Immunol. 2000
PubMed ID: 11101867
Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.
Sutton VR, Davis JE, Cancilla M, Johnstone RW, Ruefli AA, Sedelies K, Browne KA, Trapani JA
J Exp Med. 2000
PubMed ID: 11085743
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
The biochemistry of apoptosis.
Hengartner MO
Nature. 2000
PubMed ID: 11048727
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Human immunodeficiency virus type 1 Vpr induces apoptosis in human neuronal cells.
Patel CA, Mukhtar M, Pomerantz RJ
J Virol. 2000
PubMed ID: 11000244
Activation of the NF-kappaB pathway by caspase 8 and its homologs.
Chaudhary PM, Eby MT, Jasmin A, Kumar A, Liu L, Hood L
Oncogene. 2000
PubMed ID: 11002417
Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex.
Blanchard H, Donepudi M, Tschopp M, Kodandapani L, Wu JC, Grütter MG
J Mol Biol. 2000
PubMed ID: 10964557
Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis.
Stegh AH, Herrmann H, Lampel S, Weisenberger D, Andrä K, Seper M, Wiche G, Krammer PH, Peter ME
Mol Cell Biol. 2000
PubMed ID: 10891503
Properties of GST-CALM expressed in E. coli.
Kim JA, Kim SR, Jung YK, Woo SY, Seoh JY, Hong YS, Kim HL
Exp Mol Med. 2000
PubMed ID: 10926122
Dominant expression of a novel splice variant of caspase-8 in human peripheral blood lymphocytes.
Horiuchi T, Himeji D, Tsukamoto H, Harashima S, Hashimura C, Hayashi K
Biochem Biophys Res Commun. 2000
PubMed ID: 10860845
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2.
Sprick MR, Weigand MA, Rieser E, Rauch CT, Juo P, Blenis J, Krammer PH, Walczak H
Immunity. 2000
PubMed ID: 10894160
A yeast genetic assay for caspase cleavage of the amyloid-beta precursor protein.
Gunyuzlu PL, White WH, Davis GL, Hollis GF, Toyn JH
Mol Biotechnol. 2000
PubMed ID: 10911620
Divinations and surprises: genetic analysis of caspase function in mice.
Zheng TS, Flavell RA
Exp Cell Res. 2000
PubMed ID: 10739653
Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis.
Bratton SB, MacFarlane M, Cain K, Cohen GM
Exp Cell Res. 2000
PubMed ID: 10739648
Human immunodeficiency virus type 1 vpr induces apoptosis through caspase activation.
Stewart SA, Poon B, Song JY, Chen IS
J Virol. 2000
PubMed ID: 10708425
Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis.
Marissen WE, Guo Y, Thomas AA, Matts RL, Lloyd RE
J Biol Chem. 2000
PubMed ID: 10734073
BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins.
Zhang H, Xu Q, Krajewski S, Krajewska M, Xie Z, Fuess S, Kitada S, Pawlowski K, Godzik A, Reed JC
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10716992
Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies.
Wang J, Lenardo MJ
J Cell Sci. 2000
PubMed ID: 10671365
Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death.
Roth KA, Kuan C, Haydar TF, D'Sa-Eipper C, Shindler KS, Zheng TS, Kuida K, Flavell RA, Rakic P
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10618441
Apoptosis cascade progresses during turnover of human trophoblast: analysis of villous cytotrophoblast and syncytial fragments in vitro.
Huppertz B, Frank HG, Reister F, Kingdom J, Korr H, Kaufmann P
Lab Invest. 1999
PubMed ID: 10616217
Caspase knockouts: matters of life and death.
Zheng TS, Hunot S, Kuida K, Flavell RA
Cell Death Differ. 1999
PubMed ID: 10578172
Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis.
Lin Y, Devin A, Rodriguez Y, Liu ZG
Genes Dev. 1999
PubMed ID: 10521396
Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis.
Kitsberg D, Formstecher E, Fauquet M, Kubes M, Cordier J, Canton B, Pan G, Rolli M, Glowinski J, Chneiweiss H
J Neurosci. 1999
PubMed ID: 10493725
The atomic-resolution structure of human caspase-8, a key activator of apoptosis.
Watt W, Koeplinger KA, Mildner AM, Heinrikson RL, Tomasselli AG, Watenpaugh KD
Structure. 1999
PubMed ID: 10508785
The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis.
Blanchard H, Kodandapani L, Mittl PR, Marco SD, Krebs JF, Wu JC, Tomaselli KJ, Grütter MG
Structure. 1999
PubMed ID: 10508784
Roles of p53 and caspases in the induction of cell cycle arrest and apoptosis by HIV-1 vpr.
Shostak LD, Ludlow J, Fisk J, Pursell S, Rimel BJ, Nguyen D, Rosenblatt JD, Planelles V
Exp Cell Res. 1999
PubMed ID: 10438581
Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha.
Satoh S, Hijikata M, Handa H, Shimotohno K
Biochem J. 1999
PubMed ID: 10432301
PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis.
Condorelli G, Vigliotta G, Cafieri A, Trencia A, Andalò P, Oriente F, Miele C, Caruso M, Formisano P, Beguinot F
Oncogene. 1999
PubMed ID: 10442631
Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23.
Sagane K, Yamazaki K, Mizui Y, Tanaka I
Gene. 1999
PubMed ID: 10433968
Cleavage and relocation of the tyrosine kinase P59FYN during Fas-mediated apoptosis in T lymphocytes.
Ricci JE, Maulon L, Luciano F, Guerin S, Livolsi A, Mari B, Breittmayer JP, Peyron JF, Auberger P
Oncogene. 1999
PubMed ID: 10435619
Changes in nuclear morphology during apoptosis correlate with vimentin cleavage by different caspases located either upstream or downstream of Bcl-2 action.
Morishima N
Genes Cells. 1999
PubMed ID: 10469173
The modular nature of apoptotic signaling proteins.
Hofmann K
Cell Mol Life Sci. 1999
PubMed ID: 10442092
The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.
Los M, Wesselborg S, Schulze-Osthoff K
Immunity. 1999
PubMed ID: 10403638
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB.
Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Núñez G
J Biol Chem. 1999
PubMed ID: 10329646
The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis.
Imai Y, Kimura T, Murakami A, Yajima N, Sakamaki K, Yonehara S
Nature. 1999
PubMed ID: 10235259
Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/caspase-8.
Bartz SR, Emerman M
J Virol. 1999
PubMed ID: 9971775
Caspase-8 is required for cell death induced by expanded polyglutamine repeats.
Sánchez I, Xu CJ, Juo P, Kakizaka A, Blenis J, Yuan J
Neuron. 1999
PubMed ID: 10197541
Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases.
van de Craen M, de Jonghe C, van den Brande I, Declercq W, van Gassen G, van Criekinge W, Vanderhoeven I, Fiers W, van Broeckhoven C, Hendriks L, Vandenabeele P
FEBS Lett. 1999
PubMed ID: 10069390
Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis.
Walter J, Schindzielorz A, Grünberg J, Haass C
Proc Natl Acad Sci U S A. 1999
PubMed ID: 9990034
Targeted disruption of caspase genes in mice: what they tell us about the functions of individual caspases in apoptosis.
Colussi PA, Kumar S
Immunol Cell Biol. 1999
PubMed ID: 10101687
Cell death in development.
Vaux DL, Korsmeyer SJ
Cell. 1999
PubMed ID: 9988219
Structure and chromosome localization of the human CASP8 gene.
Grenet J, Teitz T, Wei T, Valentine V, Kidd VJ
Gene. 1999
PubMed ID: 9931493
Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus.
Furuyashiki T, Fujisawa K, Fujita A, Madaule P, Uchino S, Mishina M, Bito H, Narumiya S
J Neurosci. 1999
PubMed ID: 9870943
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Prodomains--adaptors--oligomerization: the pursuit of caspase activation in apoptosis.
Kumar S, Colussi PA
Trends Biochem Sci. 1999
PubMed ID: 10087912
Molecular cloning and identification of murine caspase-8.
Van de Craen M, Van Loo G, Declercq W, Schotte P, Van den brande I, Mandruzzato S, van der Bruggen P, Fiers W, Vandenabeele P
J Mol Biol. 1998
PubMed ID: 9837723
Cleavage of human cytosolic phospholipase A2 by caspase-1 (ICE) and caspase-8 (FLICE).
Lüschen S, Ussat S, Krönke M, Adam-Klages S
Biochem Biophys Res Commun. 1998
PubMed ID: 9875225
HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress.
Kruman II, Nath A, Mattson MP
Exp Neurol. 1998
PubMed ID: 9878167
Caspase-14 is a novel developmentally regulated protease.
Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM
J Biol Chem. 1998
PubMed ID: 9792675
Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy.
Granville DJ, Carthy CM, Jiang H, Shore GC, McManus BM, Hunt DW
FEBS Lett. 1998
PubMed ID: 9804161
DEDD, a novel death effector domain-containing protein, targeted to the nucleolus.
Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME
EMBO J. 1998
PubMed ID: 9774341
Death receptors: signaling and modulation.
Ashkenazi A, Dixit VM
Science. 1998
PubMed ID: 9721089
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.
Li H, Zhu H, Xu CJ, Yuan J
Cell. 1998
PubMed ID: 9727492
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.
Luo X, Budihardjo I, Zou H, Slaughter C, Wang X
Cell. 1998
PubMed ID: 9727491
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.
Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T, Holtmann H, Lonai P, Wallach D
Immunity. 1998
PubMed ID: 9729047
Phosphorylation of PITSLRE p110 isoforms accompanies their processing by caspases during Fas-mediated cell death.
Tang D, Gururajan R, Kidd VJ
J Biol Chem. 1998
PubMed ID: 9632733
ERICE, a novel FLICE-activatable caspase.
Humke EW, Ni J, Dixit VM
J Biol Chem. 1998
PubMed ID: 9624166
RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis.
Inohara N, del Peso L, Koseki T, Chen S, Núñez G
J Biol Chem. 1998
PubMed ID: 9575181
ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.
Koseki T, Inohara N, Chen S, Núñez G
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9560245
Molecular cloning and characterization of mouse caspase-8.
Sakamaki K, Tsukumo S, Yonehara S
Eur J Biochem. 1998
PubMed ID: 9654089
Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation.
Hu Y, Benedict MA, Wu D, Inohara N, Núñez G
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9539746
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR
J Biol Chem. 1998
PubMed ID: 9535906
Assignment of CASP8 to human chromosome band 2q33-->q34 and Casp8 to the murine syntenic region on chromosome 1B-proximal C by in situ hybridization.
Kischkel FC, Kioschis P, Weitz S, Poustka A, Lichter P, Krammer PH
Cytogenet Cell Genet. 1998
PubMed ID: 9763668
p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum.
Ng FW, Nguyen M, Kwan T, Branton PE, Nicholson DW, Cromlish JA, Shore GC
J Cell Biol. 1997
PubMed ID: 9334338
MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death.
Han DK, Chaudhary PM, Wright ME, Friedman C, Trask BJ, Riedel RT, Baskin DG, Schwartz SM, Hood L
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9326610
Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.
MacFarlane M, Ahmad M, Srinivasula SM, Fernandes-Alnemri T, Cohen GM, Alnemri ES
J Biol Chem. 1997
PubMed ID: 9325248
CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis.
Inohara N, Koseki T, Hu Y, Chen S, Núñez G
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9380701
A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma.
Mandruzzato S, Brasseur F, Andry G, Boon T, van der Bruggen P
J Exp Med. 1997
PubMed ID: 9271594
Caspases: the executioners of apoptosis.
Cohen GM
Biochem J. 1997
PubMed ID: 9337844
CASH, a novel caspase homologue with death effector domains.
Goltsev YV, Kovalenko AV, Arnold E, Varfolomeev EE, Brodianskii VM, Wallach D
J Biol Chem. 1997
PubMed ID: 9289491
FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis.
Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES
J Biol Chem. 1997
PubMed ID: 9228018
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease.
Kim TW, Pettingell WH, Jung YK, Kovacs DM, Tanzi RE
Science. 1997
PubMed ID: 9219695
Casper is a FADD- and caspase-related inducer of apoptosis.
Shu HB, Halpin DR, Goeddel DV
Immunity. 1997
PubMed ID: 9208847
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).
Medema JP, Scaffidi C, Kischkel FC, Shevchenko A, Mann M, Krammer PH, Peter ME
EMBO J. 1997
PubMed ID: 9184224
Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death.
Chinnaiyan AM, O'Rourke K, Lane BR, Dixit VM
Science. 1997
PubMed ID: 9027312
FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens.
Muzio M, Salvesen GS, Dixit VM
J Biol Chem. 1997
PubMed ID: 9006941
Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.
Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Litwack G, Alnemri ES
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8962078
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8755496
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.
Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM
Cell. 1996
PubMed ID: 8681377
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.
Boldin MP, Goncharov TM, Goltsev YV, Wallach D
Cell. 1996
PubMed ID: 8681376
Mch3, a novel human apoptotic cysteine protease highly related to CPP32.
Fernandes-Alnemri T, Takahashi A, Armstrong R, Krebs J, Fritz L, Tomaselli KJ, Wang L, Yu Z, Croce CM, Salveson G
Cancer Res. 1995
PubMed ID: 8521391
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
Fernandes-Alnemri T, Litwack G, Alnemri ES
J Biol Chem. 1994
PubMed ID: 7983002
Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system.
DuBridge RB, Tang P, Hsia HC, Leong PM, Miller JH, Calos MP
Mol Cell Biol. 1987
PubMed ID: 3031469
Production by EBV infection of an EBNA-positive subline from an EBNA-negative human lymphoma cell line without detectable EBV DNA.
Clements GB, Klein G, Povey S
Int J Cancer. 1975
PubMed ID: 170210

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	841	12370	64044
EnsEMBL Gene(s)	ENSG00000064012 LRG_34	ENSMUSG00000026029	ENSRNOG00000012331
Unigene	Hs.599762	Mm.336851	Rn.54474
Homologene	CASP8	Casp8	Casp8
OMIM	601763	N/A	N/A
GeneCards	CASP8	N/A	N/A
Beta Cell Genomics	DT.100028031 DT.100823820 DT.100823822 DT.100823826 DT.102826278 DT.120965031 DT.40273678 DT.86855731 DT.95069291 DT.97798900 DT.97841482 DT.97841484 DT.97841485	DT.101370778 DT.101400969 DT.87072360	N/A
Reactome	Q14790	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	841	12370	64044

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
CASP8	PARP2	HPRD	empirical	12065591
CASP8	PDIA6	IntAct	empirical	21988832
CASP8	BCAP31	HPRD, IntAct, BioGRID	empirical	9334338 12668660 21183955 11917123
CASP8	TOPORS	HPRD, MINT	empirical	17290218
CASP8	CDKN1B	HPRD	empirical	11420686
CASP8	NOD1	HPRD, BioGRID	empirical	10329646
CASP8	KHDRBS1	BioGRID	empirical	21620750
CASP8	GMEB1	HPRD	empirical	16497673
CASP8	RALBP1	HPRD, BioGRID	empirical	16227629 12887920
CASP8	RIPK3	IntAct	empirical	19524512 19524513
CASP8	CHD3	HPRD, MINT, IntAct, BioGRID	empirical	16169070
CASP8	FAF1	HPRD, BioGRID	empirical	12702723 21282461
CASP8	CHUK	HPRD, BioGRID	empirical	11002417
CASP8	CTNNB1	HPRD	empirical	12189238
CASP8	DEDD2	HPRD, BioGRID	empirical	12527898 11965497
CASP8	RYBP	HPRD	empirical	11395500
CASP8	CASP14	HPRD, BioGRID	empirical	9792675
CASP8	FYN	HPRD	empirical	10435619
CASP8	GRIA1	HPRD	empirical	11751897
CASP8	HIP1	HPRD, BioGRID	empirical	11788820
CASP8	APAF1	HPRD, BioGRID	empirical	9539746
CASP8	BIRC2	IntAct, BioGRID	empirical	12887920
CASP8	HSPA5	IntAct	empirical	19632185
CASP8	XIAP	BioGRID	empirical	11832478
CASP8	APP	HPRD	empirical	10911620
CASP8	FAS	HPRD, MINT, IntAct, MIPS, BioGRID	empirical	11101867 17159907 17159908 16498403 18328427 18455983 21382479 21625644 17047155 11717445 12887920 10196099 15659383 9208847 9325248
CASP8	IKBKB	HPRD, BioGRID	empirical	11002417
CASP8	FASLG	MINT, IntAct, BioGRID	empirical	16498403 12198154 12887920 15659383 12753742
CASP8	ILK	HPRD, IntAct	empirical	16936772
CASP8	AR	HPRD, MINT	empirical	17170703
CASP8	RHOA	BioGRID	empirical	15659383
CASP8	KRT18	HPRD	empirical	10891503
CASP8	ARHGDIA	BioGRID	empirical	15659383
CASP8	MAPT	HPRD	empirical	12888622
CASP8	MSN	BioGRID	empirical	15659383
CASP8	NCL	MINT	empirical	17290218
CASP8	NUCB1	MINT	empirical	18154733
CASP8	NUCB2	MINT	empirical	18154733
CASP8	PARK2	HPRD	empirical	12692130
CASP8	FIS1	IntAct	empirical	21183955
CASP8	BFAR	HPRD	empirical	10716992
CASP8	PCYT1A	HPRD	empirical	12052891
CASP8	HDAC7	BioGRID	empirical	18458084
CASP8	PLEC	HPRD	empirical	10891503
CASP8	IFT57	BioGRID	empirical	11788820
CASP8	PRKCI	IntAct	empirical	21988832
CASP8	PRKCZ	HPRD	empirical	11016947
CASP8	MAPK1	HPRD, MINT	empirical	17290218
CASP8	MAPK3	HPRD, MINT	empirical	17290218
CASP8	MAPK8	BioGRID	empirical	15659383
CASP8	EIF2AK2	HPRD	empirical	11555640
CASP8	PSEN1	HPRD	empirical	10069390
CASP8	PSEN2	HPRD	empirical	9990034 9219695 10069390
CASP8	OTUD7B	IntAct	empirical	19427028
CASP8	NLRC4	BioGRID	empirical	20085538
CASP8	RALGDS	BioGRID	empirical	21525013
CASP8	RB1	HPRD	empirical	15735701
CASP8	BCL2	HPRD, IntAct, BioGRID	empirical	11406564 16183855 11832478
CASP8	BCL2L1	HPRD, BioGRID	empirical	11733517 11832478
CASP8	EDA2R	HPRD, IntAct	empirical	15280356
CASP8	BID	HPRD, BioGRID	empirical	9727491 11085743 12196516 12097160 9727492 15659383 11832478
CASP8	SNRPD3	IntAct	empirical	21988832
CASP8	SRF	HPRD	empirical	11387340
CASP8	TFCP2	HPRD, MINT, IntAct, BioGRID	empirical	16169070
CASP8	TNFAIP3	BioGRID	empirical	19060883
CASP8	TNFRSF1A	BioGRID	empirical	15659383
CASP8	TRAF1	HPRD, IntAct, BioGRID	empirical	11098060 11181075 12887920
CASP8	TRAF2	HPRD, IntAct	empirical	16227629 11340079 17047155 12884866 12887920
CASP8	PLIN4	IntAct	empirical	21988832
CASP8	UBB	IntAct	empirical	19427028
CASP8	UBC	BioGRID	empirical	21628531 20972266 21139048 21906983
CASP8	UBE2D1	IntAct	empirical	19427028
CASP8	UBE2L3	IntAct	empirical	19427028
CASP8	UBE2V1	IntAct	empirical	19427028
CASP8	SUMO1	HPRD	empirical	15782135
CASP8	EZR	BioGRID	empirical	15659383
CASP8	VIM	HPRD, MINT, IntAct, BioGRID	empirical	11423904 10469173 16169070
CASP8	TNFAIP8L2	IntAct	empirical	18455983
CASP8	MAP1LC3B	BioGRID	empirical	21900206
CASP8	PICALM	HPRD	empirical	10926122
CASP8	CASP1	BioGRID	empirical	8962078
CASP8	CASP2	BioGRID	empirical	11832478 8962078
CASP8	CASP3	HPRD, BioGRID	empirical	11437602 11832478 8962078
CASP8	CASP4	BioGRID	empirical	8962078
CASP8	CASP6	HPRD, BioGRID	empirical	12232792 11832478 8962078
CASP8	CASP7	BioGRID	empirical	11832478 8962078
CASP8	CASP8	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	8681376 17290218 17170703 16169070 11717445 11832478 10964557 8962078 15254227
CASP8	CASP9	BioGRID	empirical	11832478 8962078
CASP8	STK24	HPRD	empirical	12107159
CASP8	CASP10	HPRD, MINT, IntAct, BioGRID	empirical	11717445 3031469 12198154 170210 12887920 17159907 15659383 11832478 8962078
CASP8	CUL3	IntAct	empirical	19427028
CASP8	MAP1LC3A	BioGRID	empirical	21628531
CASP8	IKBKG	HPRD	empirical	16227629
CASP8	PIAS1	HPRD	empirical	15782135
CASP8	USO1	HPRD	empirical	12438416
CASP8	PEA15	HPRD, BioGRID	empirical	10493725 10442631
CASP8	TRADD	IntAct, BioGRID	empirical	19524513 17047155 12887920
CASP8	RIPK1	HPRD, IntAct, BioGRID	empirical	11002417 10521396 12215447 18485876 19524512 19524513 21458669 21525013 17047155 12884866 12887920 19060883 18570872 21282461 20825417 19773432 21737329 22179575
CASP8	CRADD	HPRD	empirical	11002417
CASP8	TNFSF10	IntAct	empirical	19427028 12198154 10894160 20097879
CASP8	RIPK2	HPRD	empirical	9575181
CASP8	FADD	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	12107169 11717445 8681376 17159907 17290218 14612908 18485876 19524512 21988832 21458669 21525013 19001025 21785459 17047155 12884866 12887920 20103630 16469705 15659383 9228018 12911633 19060883 21737329 21620750 22179575 20448643
CASP8	TNFRSF10B	HPRD, IntAct, BioGRID	empirical	12218097 17047155 20103630 15659383 9325248 11940602 19343040
CASP8	TNFRSF10A	HPRD, IntAct, BioGRID	empirical	12218097 19427028 21251615 21785459 17047155 20103630 9325248 19343040
CASP8	CFLAR	HPRD, MINT, IntAct, BioGRID	empirical	9289491 9208847 12215447 9380701 12097160 17159907 17047155 12887920 9228018 9326610 11741985 19710364 21737329 19343040
CASP8	SQSTM1	IntAct, BioGRID	empirical	19427028 21628531 21576355
CASP8	NOL3	HPRD, IntAct	empirical	9560245 18245485 19001025
CASP8	MAP3K14	HPRD, IntAct, BioGRID	empirical	11002417 12884866
CASP8	USP2	BioGRID	empirical	22179575
CASP8	DEDD	HPRD, BioGRID	empirical	12527898 11965497 9774341
CASP8	MAP4K4	HPRD	empirical	11002417
CASP8	NR1H4	HPRD, BioGRID	empirical	11733517
CASP8	CDH1	HPRD	empirical	12189238
CASP8	CASP8AP2	HPRD, MINT, BioGRID	empirical	11340079 10235259 17245429