CANX

Summary Top Help

Gene Description:

calnexin

Synonyms:

D11Ertd153e, P90, 1110069N15Rik, AI988026, CNX, Canx, IP90, CANX, Cnx

Orthologs:

Human CANX (protein-coding), Mouse Canx (protein-coding), Rat Canx (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd4.3	Mouse	chr11:44552713..55855725	11.30	182

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr5:179105629..179158642 (531 kb) View in Genome Browser

(Mouse) NCBIM37 - chr11:50107459..50139175 (31.72 kb) View in Genome Browser

(Rat) RGSC3.4 - chr10:35850944..35883494 (32.55 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CANX:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CANX:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 3

Biocarta: 1

Reactome: 5

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 17

Publications from PubMed Top Help

Type 1 Diabetes Publications: 3

Publications: 229

Pathomechanistic characterization of two exonic L1CAM variants located in trans in an obligate carrier of X-linked hydrocephalus.
Marx M, Diestel S, Bozon M, Keglowich L, Drouot N, Bouché E, Frebourg T, Minz M, Saugier-Veber P, Castellani V, Schäfer MK
Neurogenetics. 2012
PubMed ID: 22222883
Specialization of endoplasmic reticulum chaperones for the folding and function of myelin glycoproteins P0 and PMP22.
Jung J, Coe H, Michalak M
FASEB J. 2011
PubMed ID: 21831887
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Mutational analysis of calnexin.
Groenendyk J, Dabrowska M, Michalak M
Biochim Biophys Acta. 2011
PubMed ID: 20385098
Cell surface targeting of myelin oligodendrocyte glycoprotein (MOG) in the absence of endoplasmic reticulum molecular chaperones.
Jung J, Michalak M
Biochim Biophys Acta. 2011
PubMed ID: 21172390
Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm.
Han C, Park I, Lee B, Jin S, Choi H, Kwon JT, Kwon YI, Kim do H, Park ZY, Cho C
J Cell Physiol. 2011
PubMed ID: 20945367
Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Jo Y, Sguigna PV, DeBose-Boyd RA
J Biol Chem. 2011
PubMed ID: 21343306
A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis.
Neutzner A, Neutzner M, Benischke AS, Ryu SW, Frank S, Youle RJ, Karbowski M
J Biol Chem. 2011
PubMed ID: 21205830
Association of defective HLA-I expression with antigen processing machinery and their association with clinicopathological characteristics in Kazak patients with esophageal cancer.
Ayshamgul H, Ma H, Ilyar S, Zhang LW, Abulizi A
Chin Med J (Engl). 2011
PubMed ID: 21362330
Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
Greco TM, Yu F, Guise AJ, Cristea IM
Mol Cell Proteomics. 2011
PubMed ID: 21081666
Enhanced clathrin-dependent endocytosis in the absence of calnexin.
Li HD, Liu WX, Michalak M
PLoS One. 2011
PubMed ID: 21747946
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain.
Kozlov G, Bastos-Aristizabal S, Määttänen P, Rosenauer A, Zheng F, Killikelly A, Trempe JF, Thomas DY, Gehring K
J Biol Chem. 2010
PubMed ID: 20801878
Transmembrane segments prevent surface expression of sodium channel Nav1.8 and promote calnexin-dependent channel degradation.
Li Q, Su YY, Wang H, Li L, Wang Q, Bao L
J Biol Chem. 2010
PubMed ID: 20720009
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Calnexin inhibits thermal aggregation and neurotoxicity of prion protein.
Wang W, Chen R, Luo K, Wu D, Huang L, Huang T, Xiao G
J Cell Biochem. 2010
PubMed ID: 20506117
Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development.
Kumada T, Yamanaka Y, Kitano A, Shibata M, Awaya T, Kato T, Okawa K, Abe T, Oshima N, Nakahata T, Heike T
Dev Dyn. 2010
PubMed ID: 20568244
Human delta opioid receptor biogenesis is regulated via interactions with SERCA2b and calnexin.
Tuusa JT, Leskelä TT, Petäjä-Repo UE
FEBS J. 2010
PubMed ID: 20528919
Calnexin deficiency leads to dysmyelination.
Kraus A, Groenendyk J, Bedard K, Baldwin TA, Krause KH, Dubois-Dauphin M, Dyck J, Rosenbaum EE, Korngut L, Colley NJ, Gosgnach S, Zochodne D, Todd K, Agellon LB, Michalak M
J Biol Chem. 2010
PubMed ID: 20400506
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
Mapping of domains on HIV envelope protein mediating association with calnexin and protein-disulfide isomerase.
Papandréou MJ, Barbouche R, Guieu R, Rivera S, Fantini J, Khrestchatisky M, Jones IM, Fenouillet E
J Biol Chem. 2010
PubMed ID: 20202930
Cyclophilin C-associated protein/Mac-2 binding protein colocalizes with calnexin and regulates the expression of tissue transglutaminase.
Kong W, Lin BW, Li S, Longaker MT, Lorenz HP
J Cell Physiol. 2010
PubMed ID: 20049854
The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons.
Hryciw T, MacDonald JI, Phillips R, Seah C, Pasternak S, Meakin SO
J Neurochem. 2010
PubMed ID: 19943849
Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs.
Bollo M, Paredes RM, Holstein D, Zheleznova N, Camacho P, Lechleiter JD
PLoS One. 2010
PubMed ID: 20700529
Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling.
Mao C, Wang M, Luo B, Wey S, Dong D, Wesselschmidt R, Rawlings S, Lee AS
PLoS One. 2010
PubMed ID: 20520781
Growth of peripheral and central nervous system tumors is supported by cytoplasmic c-Fos in humans and mice.
Silvestre DC, Gil GA, Tomasini N, Bussolino DF, Caputto BL
PLoS One. 2010
PubMed ID: 20209053
Calnexin phosphorylation attenuates the release of partially misfolded alpha1-antitrypsin to the secretory pathway.
Cameron PH, Chevet E, Pluquet O, Thomas DY, Bergeron JJ
J Biol Chem. 2009
PubMed ID: 19815548
Calnexin improves the folding efficiency of mutant rhodopsin in the presence of pharmacological chaperone 11-cis-retinal.
Noorwez SM, Sama RR, Kaushal S
J Biol Chem. 2009
PubMed ID: 19801547
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Altered expression of glycoproteins on the cell surface of Jurkat cells during etoposide-induced apoptosis: shedding and intracellular translocation of glycoproteins.
Sato H, Azuma Y, Higai K, Matsumoto K
Biochim Biophys Acta. 2009
PubMed ID: 19524015
Cloning of mouse ojoplano, a reticular cytoplasmic protein expressed during embryonic development.
Mertes F, Martinez-Morales JR, Nolden T, Spörle R, Wittbrodt J, Lehrach H, Himmelbauer H
Gene Expr Patterns. 2009
PubMed ID: 19766735
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors.
Rezvani K, Teng Y, Pan Y, Dani JA, Lindstrom J, García Gras EA, McIntosh JM, De Biasi M
J Neurosci. 2009
PubMed ID: 19474315
Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.
Combes AN, Lesieur E, Harley VR, Sinclair AH, Little MH, Wilhelm D, Koopman P
Dev Dyn. 2009
PubMed ID: 19334288
Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ
Mol Cell Proteomics. 2009
PubMed ID: 19131326
In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12I protein.
Fukumoto R, Andresen V, Bialuk I, Cecchinato V, Walser JC, Valeri VW, Nauroth JM, Gessain A, Nicot C, Franchini G
Blood. 2009
PubMed ID: 18791162
ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules, and it enhances peptide loading independently of its redox activity.
Zhang Y, Kozlov G, Pocanschi CL, Brockmeier U, Ireland BS, Maattanen P, Howe C, Elliott T, Gehring K, Williams DB
J Biol Chem. 2009
PubMed ID: 19196713
Accessory proteins are vital for the functional expression of certain G protein-coupled receptors.
Cooray SN, Chan L, Webb TR, Metherell L, Clark AJ
Mol Cell Endocrinol. 2009
PubMed ID: 19000738
Substrate specificity of the oxidoreductase ERp57 is determined primarily by its interaction with calnexin and calreticulin.
Jessop CE, Tavender TJ, Watkins RH, Chambers JE, Bulleid NJ
J Biol Chem. 2009
PubMed ID: 19054761
Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice.
Wang X, Rao RP, Kosakowska-Cholody T, Masood MA, Southon E, Zhang H, Berthet C, Nagashim K, Veenstra TK, Tessarollo L, Acharya U, Acharya JK
J Cell Biol. 2009
PubMed ID: 19139267
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
The phagosomal proteome in interferon-gamma-activated macrophages.
Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P
Immunity. 2009
PubMed ID: 19144319
Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.
Wang B, Malik R, Nigg EA, Körner R
Anal Chem. 2008
PubMed ID: 19007248
Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
Carrascal M, Ovelleiro D, Casas V, Gay M, Abian J
J Proteome Res. 2008
PubMed ID: 19367720
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
Endoplasmic reticulum stress in the absence of calnexin.
Coe H, Bedard K, Groenendyk J, Jung J, Michalak M
Cell Stress Chaperones. 2008
PubMed ID: 18528784
Assembly and misassembly of cystic fibrosis transmembrane conductance regulator: folding defects caused by deletion of F508 occur before and after the calnexin-dependent association of membrane spanning domain (MSD) 1 and MSD2.
Rosser MF, Grove DE, Chen L, Cyr DM
Mol Biol Cell. 2008
PubMed ID: 18716059
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.
Zhou H, Ye M, Dong J, Han G, Jiang X, Wu R, Zou H
J Proteome Res. 2008
PubMed ID: 18630941
Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals.
Boden G, Duan X, Homko C, Molina EJ, Song W, Perez O, Cheung P, Merali S
Diabetes. 2008
PubMed ID: 18567819
Role of calnexin in the ER quality control and productive folding of CFTR; differential effect of calnexin knockout on wild-type and DeltaF508 CFTR.
Okiyoneda T, Niibori A, Harada K, Kohno T, Michalak M, Duszyk M, Wada I, Ikawa M, Shuto T, Suico MA, Kai H
Biochim Biophys Acta. 2008
PubMed ID: 18457676
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
The subcellular distribution of calnexin is mediated by PACS-2.
Myhill N, Lynes EM, Nanji JA, Blagoveshchenskaya AD, Fei H, Carmine Simmen K, Cooper TJ, Thomas G, Simmen T
Mol Biol Cell. 2008
PubMed ID: 18417615
Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria.
Kiebish MA, Han X, Cheng H, Lunceford A, Clarke CF, Moon H, Chuang JH, Seyfried TN
J Neurochem. 2008
PubMed ID: 18373617
The role of tapasin in MHC class I protein trafficking in embryos and T cells.
Lampton PW, Goldstein CY, Warner CM
J Reprod Immunol. 2008
PubMed ID: 18061684
Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodies.
Korkhov VM, Milan-Lobo L, Zuber B, Farhan H, Schmid JA, Freissmuth M, Sitte HH
J Mol Biol. 2008
PubMed ID: 18367207
Getting in and out from calnexin/calreticulin cycles.
Caramelo JJ, Parodi AJ
J Biol Chem. 2008
PubMed ID: 18303019
Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
Han G, Ye M, Zhou H, Jiang X, Feng S, Jiang X, Tian R, Wan D, Zou H, Gu J
Proteomics. 2008
PubMed ID: 18318008
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Phosphoproteome of resting human platelets.
Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schütz C, Walter U, Gambaryan S, Sickmann A
J Proteome Res. 2008
PubMed ID: 18088087
Calnexin is not essential for mammalian rod opsin biogenesis.
Kosmaoglou M, Cheetham ME
Mol Vis. 2008
PubMed ID: 19116670
Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation.
Ballar P, Zhong Y, Nagahama M, Tagaya M, Shen Y, Fang S
J Biol Chem. 2007
PubMed ID: 17872946
MARCKS-like protein, a membrane protein identified for its expression in developing neural retina, plays a role in regulating retinal cell proliferation.
Zhao J, Izumi T, Nunomura K, Satoh S, Watanabe S
Biochem J. 2007
PubMed ID: 17688421
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD
J Proteome Res. 2007
PubMed ID: 17924679
Endoplasmic reticulum stress during the embryonic development of the central nervous system in the mouse.
Zhang X, Szabo E, Michalak M, Opas M
Int J Dev Neurosci. 2007
PubMed ID: 17913437
Endoplasmic reticulum chaperones stabilize nicotinic receptor subunits and regulate receptor assembly.
Wanamaker CP, Green WN
J Biol Chem. 2007
PubMed ID: 17728248
Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse.
Zhang M, Hu P, Krois CR, Kane MA, Napoli JL
FASEB J. 2007
PubMed ID: 17435174
A differential phosphoproteomic analysis of retinoic acid-treated P19 cells.
Smith JC, Duchesne MA, Tozzi P, Ethier M, Figeys D
J Proteome Res. 2007
PubMed ID: 17622165
Substrate-specific requirements for UGT1-dependent release from calnexin.
Soldà T, Galli C, Kaufman RJ, Molinari M
Mol Cell. 2007
PubMed ID: 17643373
D1 and D2 dopamine receptor expression is regulated by direct interaction with the chaperone protein calnexin.
Free RB, Hazelwood LA, Cabrera DM, Spalding HN, Namkung Y, Rankin ML, Sibley DR
J Biol Chem. 2007
PubMed ID: 17395585
Calumin, a novel Ca2+-binding transmembrane protein on the endoplasmic reticulum.
Zhang M, Yamazaki T, Yazawa M, Treves S, Nishi M, Murai M, Shibata E, Zorzato F, Takeshima H
Cell Calcium. 2007
PubMed ID: 17204322
ERp57 interacts with conserved cysteine residues in the MHC class I peptide-binding groove.
Antoniou AN, Santos SG, Campbell EC, Lynch S, Arosa FA, Powis SJ
FEBS Lett. 2007
PubMed ID: 17467700
Expression of the murine Pomt1 gene in both the developing brain and adult muscle tissues and its relationship with clinical aspects of Walker-Warburg syndrome.
Prados B, Peña A, Cotarelo RP, Valero MC, Cruces J
Am J Pathol. 2007
PubMed ID: 17456771
Purification and identification of G protein-coupled receptor protein complexes under native conditions.
Daulat AM, Maurice P, Froment C, Guillaume JL, Broussard C, Monsarrat B, Delagrange P, Jockers R
Mol Cell Proteomics. 2007
PubMed ID: 17215244
Identification of novel proteins associated with both alpha-synuclein and DJ-1.
Jin J, Li GJ, Davis J, Zhu D, Wang Y, Pan C, Zhang J
Mol Cell Proteomics. 2007
PubMed ID: 16854843
Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.
Tu LC, Yan X, Hood L, Lin B
Mol Cell Proteomics. 2007
PubMed ID: 17220478
Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.
Lee J, Xu Y, Chen Y, Sprung R, Kim SC, Xie S, Zhao Y
Mol Cell Proteomics. 2007
PubMed ID: 17208939
Molecular pathogenesis of seipin/BSCL2-related motor neuron diseases.
Ito D, Suzuki N
Ann Neurol. 2007
PubMed ID: 17387721
Calnexin-dependent regulation of tunicamycin-induced apoptosis in breast carcinoma MCF-7 cells.
Delom F, Emadali A, Cocolakis E, Lebrun JJ, Nantel A, Chevet E
Cell Death Differ. 2007
PubMed ID: 16858427
Regulation of calnexin sub-cellular localization modulates endoplasmic reticulum stress-induced apoptosis in MCF-7 cells.
Delom F, Fessart D, Chevet E
Apoptosis. 2007
PubMed ID: 17203246
Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM
Mol Cell Proteomics. 2007
PubMed ID: 17114649
Differentially expressed genes in embryonic cardiac tissues of mice lacking Folr1 gene activity.
Zhu H, Cabrera RM, Wlodarczyk BJ, Bozinov D, Wang D, Schwartz RJ, Finnell RH
BMC Dev Biol. 2007
PubMed ID: 18028541
Calnexin regulated gonadotropin-releasing hormone receptor plasma membrane expression.
Brothers SP, Janovick JA, Conn PM
J Mol Endocrinol. 2006
PubMed ID: 17170088
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins.
Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM, Mori K, Sadighi Akha AA, Raden D, Kaufman RJ
PLoS Biol. 2006
PubMed ID: 17090218
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF
J Proteome Res. 2006
PubMed ID: 17081065
N-glycosylation of human nicastrin is required for interaction with the lectins from the secretory pathway calnexin and ERGIC-53.
Morais VA, Brito C, Pijak DS, Crystal AS, Fortna RR, Li T, Wong PC, Doms RW, Costa J
Biochim Biophys Acta. 2006
PubMed ID: 16938437
GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development.
Luo S, Mao C, Lee B, Lee AS
Mol Cell Biol. 2006
PubMed ID: 16847323
The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis.
Raschperger E, Thyberg J, Pettersson S, Philipson L, Fuxe J, Pettersson RF
Exp Cell Res. 2006
PubMed ID: 16542650
The effect of aging on the chaperone concentrations in the hepatic, endoplasmic reticulum of male rats: the possible role of protein misfolding due to the loss of chaperones in the decline in physiological function seen with age.
Erickson RR, Dunning LM, Holtzman JL
J Gerontol A Biol Sci Med Sci. 2006
PubMed ID: 16720739
Phosphoproteome analysis of the human mitotic spindle.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16565220
Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat.
Norez C, Noel S, Wilke M, Bijvelds M, Jorna H, Melin P, DeJonge H, Becq F
FEBS Lett. 2006
PubMed ID: 16546175
alphaIIbbeta3 biogenesis is controlled by engagement of alphaIIb in the calnexin cycle via the N15-linked glycan.
Mitchell WB, Li J, French DL, Coller BS
Blood. 2006
PubMed ID: 16304048
Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum.
Williams DB
J Cell Sci. 2006
PubMed ID: 16467570
Development of a deer mouse whole-genome radiation hybrid panel and comparative mapping of Mus chromosome 11 loci.
Ramsdell CM, Thames EL, Weston JL, Dewey MJ
Mamm Genome. 2006
PubMed ID: 16416089
Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS.
Moser K, White FM
J Proteome Res. 2006
PubMed ID: 16396499
Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes.
Maric J, Kiss RS, Franklin V, Marcel YL
J Biol Chem. 2005
PubMed ID: 16204232
Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice.
Pontén A, Folestad EB, Pietras K, Eriksson U
Circ Res. 2005
PubMed ID: 16224065
Mixed-disulfide folding intermediates between thyroglobulin and endoplasmic reticulum resident oxidoreductases ERp57 and protein disulfide isomerase.
Di Jeso B, Park YN, Ulianich L, Treglia AS, Urbanas ML, High S, Arvan P
Mol Cell Biol. 2005
PubMed ID: 16260597
Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
Polypeptide substrate recognition by calnexin requires specific conformations of the calnexin protein.
Thammavongsa V, Mancino L, Raghavan M
J Biol Chem. 2005
PubMed ID: 16061483
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with beta 2-microglobulin in the endoplasmic reticulum.
Zhu X, Peng J, Chen D, Liu X, Ye L, Iijima H, Kadavil K, Lencer WI, Blumberg RS
J Immunol. 2005
PubMed ID: 16002696
Global phosphoproteome of HT-29 human colon adenocarcinoma cells.
Kim JE, Tannenbaum SR, White FM
J Proteome Res. 2005
PubMed ID: 16083285
Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin.
Farinha CM, Amaral MD
Mol Cell Biol. 2005
PubMed ID: 15923638
Soluble tyrosinase is an endoplasmic reticulum (ER)-associated degradation substrate retained in the ER by calreticulin and BiP/GRP78 and not calnexin.
Popescu CI, Paduraru C, Dwek RA, Petrescu SM
J Biol Chem. 2005
PubMed ID: 15677452
Overexpression of ERp29 in the thyrocytes of FRTL-5 cells.
Park S, You KH, Shong M, Goo TW, Yun EY, Kang SW, Kwon OY
Mol Biol Rep. 2005
PubMed ID: 15865205
Proteomic analysis of in vivo phosphorylated synaptic proteins.
Collins MO, Yu L, Coba MP, Husi H, Campuzano I, Blackstock WP, Choudhary JS, Grant SG
J Biol Chem. 2005
PubMed ID: 15572359
Glycan-independent role of calnexin in the intracellular retention of Charcot-Marie-tooth 1A Gas3/PMP22 mutants.
Fontanini A, Chies R, Snapp EL, Ferrarini M, Fabrizi GM, Brancolini C
J Biol Chem. 2005
PubMed ID: 15537650
Age-related decline in expression of calnexin.
Choi BH, Kim JS
Exp Mol Med. 2004
PubMed ID: 15557823
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis.
Watanabe K, Hasegawa Y, Yamashita H, Shimizu K, Ding Y, Abe M, Ohta H, Imagawa K, Hojo K, Maki H, Sonoda H, Sato Y
J Clin Invest. 2004
PubMed ID: 15467828
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway.
Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, Zheng H, Saftig P, De Strooper B, Klumperman J, Annaert W
J Cell Biol. 2004
PubMed ID: 15452145
The DNA sequence and comparative analysis of human chromosome 5.
Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM
Nature. 2004
PubMed ID: 15372022
Cleavage of calnexin caused by apoptotic stimuli: implication for the regulation of apoptosis.
Takizawa T, Tatematsu C, Watanabe K, Kato K, Nakanishi Y
J Biochem. 2004
PubMed ID: 15598898
Protein folding and quality control in the endoplasmic reticulum.
Kleizen B, Braakman I
Curr Opin Cell Biol. 2004
PubMed ID: 15261665
ER-60 domains responsible for interaction with calnexin and calreticulin.
Urade R, Okudo H, Kato H, Moriyama T, Arakaki Y
Biochemistry. 2004
PubMed ID: 15236594
Functional proteomics mapping of a human signaling pathway.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM
Genome Res. 2004
PubMed ID: 15231748
Transient calnexin interaction confers long-term stability on folded K+ channel protein in the ER.
Khanna R, Lee EJ, Papazian DM
J Cell Sci. 2004
PubMed ID: 15161937
A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet.
Cao J, Hawkins E, Brozinick J, Liu X, Zhang H, Burn P, Shi Y
J Biol Chem. 2004
PubMed ID: 14966132
Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects.
Egan ME, Pearson M, Weiner SA, Rajendran V, Rubin D, Glöckner-Pagel J, Canny S, Du K, Lukacs GL, Caplan MJ
Science. 2004
PubMed ID: 15105504
Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-aspartate NR1/NR2 receptors.
Papadakis M, Hawkins LM, Stephenson FA
J Biol Chem. 2004
PubMed ID: 14732708
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
The low-density lipoprotein receptor-related protein associates with calnexin, calreticulin, and protein disulfide isomerase in receptor-associated-protein-deficient fibroblasts.
Orlando RA
Exp Cell Res. 2004
PubMed ID: 14980518
Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.
Shu H, Chen S, Bi Q, Mumby M, Brekken DL
Mol Cell Proteomics. 2004
PubMed ID: 14729942
Differential downregulation of endoplasmic reticulum-residing chaperones calnexin and calreticulin in human metastatic melanoma.
Dissemond J, Busch M, Kothen T, Mörs J, Weimann TK, Lindeke A, Goos M, Wagner SN
Cancer Lett. 2004
PubMed ID: 14732231
Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality control.
Molinari M, Eriksson KK, Calanca V, Galli C, Cresswell P, Michalak M, Helenius A
Mol Cell. 2004
PubMed ID: 14731400
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
A role for palmitoylation in the quality control, assembly and secretion of apolipoprotein B.
Vilas GL, Berthiaume LG
Biochem J. 2004
PubMed ID: 14498830
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes.
Rouvinski A, Gahali-Sass I, Stav I, Metzer E, Atlan H, Taraboulos A
Biochem Biophys Res Commun. 2003
PubMed ID: 12927782
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Role of calnexin in the glycan-independent quality control of proteolipid protein.
Swanton E, High S, Woodman P
EMBO J. 2003
PubMed ID: 12805210
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
Chen F, Tandon A, Sanjo N, Gu YJ, Hasegawa H, Arawaka S, Lee FJ, Ruan X, Mastrangelo P, Erdebil S, Wang L, Westaway D, Mount HT, Yankner B, Fraser PE, St George-Hyslop P
J Biol Chem. 2003
PubMed ID: 12646573
Compromised calnexin function in calreticulin-deficient cells.
Knee R, Ahsan I, Mesaeli N, Kaufman RJ, Michalak M
Biochem Biophys Res Commun. 2003
PubMed ID: 12727205
Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge.
Ohishi K, Nagamune K, Maeda Y, Kinoshita T
J Biol Chem. 2003
PubMed ID: 12582175
Apolipoprotein[a] secretion from hepatoma cells is regulated in a size-dependent manner by alterations in disulfide bond formation.
Nassir F, Xie Y, Davidson NO
J Lipid Res. 2003
PubMed ID: 12562843
Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle.
Molinari M, Calanca V, Galli C, Lucca P, Paganetti P
Science. 2003
PubMed ID: 12610306
EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin.
Oda Y, Hosokawa N, Wada I, Nagata K
Science. 2003
PubMed ID: 12610305
Isolation and characterisation of a calnexin homologue, clxA, from Aspergillus niger.
Wang H, Entwistle J, Morlon E, Archer DB, Peberdy JF, Ward M, Jeenes DJ
Mol Genet Genomics. 2003
PubMed ID: 12589443
Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.
Basrur V, Yang F, Kushimoto T, Higashimoto Y, Yasumoto K, Valencia J, Muller J, Vieira WD, Watabe H, Shabanowitz J, Hearing VJ, Hunt DF, Appella E
J Proteome Res. 2003
PubMed ID: 12643545
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Distinct expression of calnexin in major human salivary glands.
Gassler N, Bohn J, Schnölzer M, Scheuerer J, Obermüller N, Otto HF, Autschbach F
Histol Histopathol. 2003
PubMed ID: 12507291
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain.
Kang SJ, Cresswell P
J Biol Chem. 2002
PubMed ID: 12239218
Early postnatal death and motor disorders in mice congenitally deficient in calnexin expression.
Denzel A, Molinari M, Trigueros C, Martin JE, Velmurgan S, Brown S, Stamp G, Owen MJ
Mol Cell Biol. 2002
PubMed ID: 12370287
Association of the thyrotropin receptor with calnexin, calreticulin and BiP. Efects on the maturation of the receptor.
Siffroi-Fernandez S, Giraud A, Lanet J, Franc JL
Eur J Biochem. 2002
PubMed ID: 12383251
Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins.
Boyd GW, Low P, Dunlop JI, Robertson LA, Vardy A, Lambert JJ, Peters JA, Connolly CN
Mol Cell Neurosci. 2002
PubMed ID: 12359150
Calnexin Delta 185-520 partially reverses the misprocessing of the Delta F508 cystic fibrosis transmembrane conductance regulator.
Okiyoneda T, Wada I, Jono H, Shuto T, Yoshitake K, Nakano N, Nagayama S, Harada K, Isohama Y, Miyata T, Kai H
FEBS Lett. 2002
PubMed ID: 12208510
Localization of the lectin, ERp57 binding, and polypeptide binding sites of calnexin and calreticulin.
Leach MR, Cohen-Doyle MF, Thomas DY, Williams DB
J Biol Chem. 2002
PubMed ID: 12052826
Association of calnexin with mutant peripheral myelin protein-22 ex vivo: a basis for "gain-of-function" ER diseases.
Dickson KM, Bergeron JJ, Shames I, Colby J, Nguyen DT, Chevet E, Thomas DY, Snipes GJ
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12119418
Reconstitution of transport-active multidrug resistance protein 2 (MRP2; ABCC2) in proteoliposomes.
Hagmann W, Schubert J, König J, Keppler D
Biol Chem. 2002
PubMed ID: 12222674
Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity.
Elagoz A, Benjannet S, Mammarbassi A, Wickham L, Seidah NG
J Biol Chem. 2002
PubMed ID: 11756446
The prosequence of human lactase-phlorizin hydrolase modulates the folding of the mature enzyme.
Jacob R, Peters K, Naim HY
J Biol Chem. 2002
PubMed ID: 11751874
Calnexin deficiency and endoplasmic reticulum stress-induced apoptosis.
Zuppini A, Groenendyk J, Cormack LA, Shore G, Opas M, Bleackley RC, Michalak M
Biochemistry. 2002
PubMed ID: 11851433
Localization of neutral ceramidase in caveolin-enriched light membranes of murine endothelial cells.
Romiti E, Meacci E, Tanzi G, Becciolini L, Mitsutake S, Farnararo M, Ito M, Bruni P
FEBS Lett. 2001
PubMed ID: 11591392
The Structure of calnexin, an ER chaperone involved in quality control of protein folding.
Schrag JD, Bergeron JJ, Li Y, Borisova S, Hahn M, Thomas DY, Cygler M
Mol Cell. 2001
PubMed ID: 11583625
Effect of gestational ethanol exposure on the NMDA receptor complex in rat forebrain: from gene transcription to cell surface.
Hughes PD, Wilson WR, Leslie SW
Brain Res Dev Brain Res. 2001
PubMed ID: 11506858
Importance of the T cell receptor alpha-chain transmembrane distal region for assembly with cognate subunits.
Shelton JG, Gülland S, Nicolson K, Kearse KP, Bäckström BT
Mol Immunol. 2001
PubMed ID: 11566319
Quality control of transmembrane domain assembly in the tetraspanin CD82.
Cannon KS, Cresswell P
EMBO J. 2001
PubMed ID: 11350933
Characterization of the biosynthesis of human immunodeficiency virus type 1 Env from infected T-cells and the effects of glucose trimming of Env on virion infectivity.
Dettenhofer M, Yu XF
J Biol Chem. 2001
PubMed ID: 11054427
Functional expression of the new gap junction gene connexin47 transcribed in mouse brain and spinal cord neurons.
Teubner B, Odermatt B, Guldenagel M, Sohl G, Degen J, Bukauskas F, Kronengold J, Verselis VK, Jung YT, Kozak CA, Schilling K, Willecke K
J Neurosci. 2001
PubMed ID: 11160382
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
The measles virus (MV) glycoproteins interact with cellular chaperones in the endoplasmic reticulum and MV infection upregulates chaperone expression.
Bolt G
Arch Virol. 2001
PubMed ID: 11765911
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo.
Pelletier MF, Marcil A, Sevigny G, Jakob CA, Tessier DC, Chevet E, Menard R, Bergeron JJ, Thomas DY
Glycobiology. 2000
PubMed ID: 10929008
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
The HIV-1 Env protein signal sequence retards its cleavage and down-regulates the glycoprotein folding.
Li Y, Luo L, Thomas DY, Kang CY
Virology. 2000
PubMed ID: 10873786
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
Protein-disulfide isomerase (PDI) in FRTL5 cells. pH-dependent thyroglobulin/PDI interactions determine a novel PDI function in the post-endoplasmic reticulum of thyrocytes.
Mezghrani A, Courageot J, Mani JC, Pugniere M, Bastiani P, Miquelis R
J Biol Chem. 2000
PubMed ID: 10636893
Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation.
Yamaguchi A, Hori O, Stern DM, Hartmann E, Ogawa S, Tohyama M
J Cell Biol. 1999
PubMed ID: 10601334
Syntaxin 3 and Munc-18-2 in epithelial cells during kidney development.
Lehtonen S, Riento K, Olkkonen VM, Lehtonen E
Kidney Int. 1999
PubMed ID: 10469351
Calnexin and the immunoglobulin binding protein (BiP) coimmunoprecipitate with AMPA receptors.
Rubio ME, Wenthold RJ
J Neurochem. 1999
PubMed ID: 10461883
Biosynthesis of inositol trisphosphate receptors: selective association with the molecular chaperone calnexin.
Joseph SK, Boehning D, Bokkala S, Watkins R, Widjaja J
Biochem J. 1999
PubMed ID: 10432312
ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin.
Oliver JD, Roderick HL, Llewellyn DH, High S
Mol Biol Cell. 1999
PubMed ID: 10436013
Phosphorylation by CK2 and MAPK enhances calnexin association with ribosomes.
Chevet E, Wong HN, Gerber D, Cochet C, Fazel A, Cameron PH, Gushue JN, Thomas DY, Bergeron JJ
EMBO J. 1999
PubMed ID: 10393181
Calnexin interaction with N-glycosylation mutants of a polytopic membrane glycoprotein, the human erythrocyte anion exchanger 1 (band 3).
Popov M, Reithmeier RA
J Biol Chem. 1999
PubMed ID: 10364201
Molecular chaperones stimulate the functional expression of the cocaine-sensitive serotonin transporter.
Tate CG, Whiteley E, Betenbaugh MJ
J Biol Chem. 1999
PubMed ID: 10364189
Genes regulating MHC class I processing of antigen.
van Endert PM
Curr Opin Immunol. 1999
PubMed ID: 10047538
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Proteasome-mediated degradation of apolipoprotein B targets both nascent peptides cotranslationally before translocation and full-length apolipoprotein B after translocation into the endoplasmic reticulum.
Liao W, Yeung SC, Chan L
J Biol Chem. 1998
PubMed ID: 9765244
Inhibition of N-linked glycosylation results in retention of intracellular apo[a] in hepatoma cells, although nonglycosylated and immature forms of apolipoprotein[a] are competent to associate with apolipoprotein B-100 in vitro.
Bonen DK, Nassir F, Hausman AM, Davidson NO
J Lipid Res. 1998
PubMed ID: 9717723
Conserved in vivo phosphorylation of calnexin at casein kinase II sites as well as a protein kinase C/proline-directed kinase site.
Wong HN, Ward MA, Bell AW, Chevet E, Bains S, Blackstock WP, Solari R, Thomas DY, Bergeron JJ
J Biol Chem. 1998
PubMed ID: 9642293
Targeting of endoplasmic reticulum-associated proteins to axons and dendrites in rotavirus-infected neurons.
Weclewicz K, Svensson L, Kristensson K
Brain Res Bull. 1998
PubMed ID: 9671265
ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly.
Lindquist JA, Jensen ON, Mann M, Hämmerling GJ
EMBO J. 1998
PubMed ID: 9545232
Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin.
Pipe SW, Morris JA, Shah J, Kaufman RJ
J Biol Chem. 1998
PubMed ID: 9525969
Association of gonadotropin receptor precursors with the protein folding chaperone calnexin.
Rozell TG, Davis DP, Chai Y, Segaloff DL
Endocrinology. 1998
PubMed ID: 9528938
Promotion of transferrin folding by cyclic interactions with calnexin and calreticulin.
Wada I, Kai M, Imai S, Sakane F, Kanoh H
EMBO J. 1997
PubMed ID: 9312001
CD9, but not other tetraspans, associates with the beta1 integrin precursor.
Rubinstein E, Poindessous-Jazat V, Le Naour F, Billard M, Boucheix C
Eur J Immunol. 1997
PubMed ID: 9295027
Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells.
Hay JC, Chao DS, Kuo CS, Scheller RH
Cell. 1997
PubMed ID: 9094723
Large-scale concatenation cDNA sequencing.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA
Genome Res. 1997
PubMed ID: 9110174
Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of "ER-resident" molecular chaperones.
Wiest DL, Bhandoola A, Punt J, Kreibich G, McKean D, Singer A
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9050874
Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome.
Gruenheid S, Pinner E, Desjardins M, Gros P
J Exp Med. 1997
PubMed ID: 9034150
Interactions between newly synthesized glycoproteins, calnexin and a network of resident chaperones in the endoplasmic reticulum.
Tatu U, Helenius A
J Cell Biol. 1997
PubMed ID: 9024687
Endoplasmic reticulum glucosidase II is composed of a catalytic subunit, conserved from yeast to mammals, and a tightly bound noncatalytic HDEL-containing subunit.
Trombetta ES, Simons JF, Helenius A
J Biol Chem. 1996
PubMed ID: 8910335
Involvement of the chaperone protein calnexin and the acetylcholine receptor beta-subunit in the assembly and cell surface expression of the receptor.
Keller SH, Lindstrom J, Taylor P
J Biol Chem. 1996
PubMed ID: 8798466
Effects of inefficient cleavage of the signal sequence of HIV-1 gp 120 on its association with calnexin, folding, and intracellular transport.
Li Y, Bergeron JJ, Luo L, Ou WJ, Thomas DY, Kang CY
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8790377
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
The glut 1 glucose transporter interacts with calnexin and calreticulin.
Oliver JD, Hresko RC, Mueckler M, High S
J Biol Chem. 1996
PubMed ID: 8662691
Calnexin associates exclusively with individual CD3 delta and T cell antigen receptor (TCR) alpha proteins containing incompletely trimmed glycans that are not assembled into multisubunit TCR complexes.
van Leeuwen JE, Kearse KP
J Biol Chem. 1996
PubMed ID: 8621641
A "double adaptor" method for improved shotgun library construction.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA
Anal Biochem. 1996
PubMed ID: 8619474
A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes.
Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M
J Virol. 1996
PubMed ID: 8551575
Retinol binding protein and transthyretin are secreted as a complex formed in the endoplasmic reticulum in HepG2 human hepatocarcinoma cells.
Bellovino D, Morimoto T, Tosetti F, Gaetani S
Exp Cell Res. 1996
PubMed ID: 8549676
Calreticulin interacts with newly synthesized human immunodeficiency virus type 1 envelope glycoprotein, suggesting a chaperone function similar to that of calnexin.
Otteken A, Moss B
J Biol Chem. 1996
PubMed ID: 8550632
The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes.
Wiest DL, Burgess WH, McKean D, Kearse KP, Singer A
EMBO J. 1995
PubMed ID: 7628443
Aglycosylated and phosphatidylinositol-anchored MHC class I molecules are associated with calnexin. Evidence implicating the class I-connecting peptide segment in calnexin association.
Carreno BM, Schreiber KL, McKean DJ, Stroynowski I, Hansen TH
J Immunol. 1995
PubMed ID: 7730623
Localization of three genes expressed in retina on mouse chromosome 11.
Kozak CA, Danciger M, Bowes C, Adamson MC, Palczewski K, Polans AS, Farber DB
Mamm Genome. 1995
PubMed ID: 7767000
Molecular cloning and sequencing of calnexin-t. An abundant male germ cell-specific calcium-binding protein of the endoplasmic reticulum.
Ohsako S, Hayashi Y, Bunick D
J Biol Chem. 1994
PubMed ID: 8188695
Participation of the endoplasmic reticulum chaperone calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator.
Pind S, Riordan JR, Williams DB
J Biol Chem. 1994
PubMed ID: 7513695
The integrin chains beta 1 and alpha 6 associate with the chaperone calnexin prior to integrin assembly.
Lenter M, Vestweber D
J Biol Chem. 1994
PubMed ID: 8163531
Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5.
Tjoelker LW, Seyfried CE, Eddy RL, Byers MG, Shows TB, Calderon J, Schreiber RB, Gray PW
Biochemistry. 1994
PubMed ID: 8136357
Calnexin: a membrane-bound chaperone of the endoplasmic reticulum.
Bergeron JJ, Brenner MB, Thomas DY, Williams DB
Trends Biochem Sci. 1994
PubMed ID: 8203019
The molecular chaperones HSP28, GRP78, endoplasmin, and calnexin exhibit strikingly different levels in quiescent keratinocytes as compared to their proliferating normal and transformed counterparts: cDNA cloning and expression of calnexin.
Honoré B, Rasmussen HH, Celis A, Leffers H, Madsen P, Celis JE
Electrophoresis. 1994
PubMed ID: 8055875
Retention of unassembled components of integral membrane proteins by calnexin.
Rajagopalan S, Xu Y, Brenner MB
Science. 1994
PubMed ID: 8278814
Class II histocompatibility molecules associate with calnexin during assembly in the endoplasmic reticulum.
Schreiber KL, Bell MP, Huntoon CJ, Rajagopalan S, Brenner MB, McKean DJ
Int Immunol. 1994
PubMed ID: 8148318
Interaction with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin).
David V, Hochstenbach F, Rajagopalan S, Brenner MB
J Biol Chem. 1993
PubMed ID: 8486646
Identification and purification of a calcium-binding protein in hepatic nuclear membranes.
Gilchrist JS, Pierce GN
J Biol Chem. 1993
PubMed ID: 8440713
Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.
Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J
Electrophoresis. 1992
PubMed ID: 1286667
The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene.
Galvin K, Krishna S, Ponchel F, Frohlich M, Cummings DE, Carlson R, Wands JR, Isselbacher KJ, Pillai S, Ozturk M
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1326756
The endoplasmic reticulum of Purkinje neuron body and dendrites: molecular identity and specializations for Ca2+ transport.
Villa A, Sharp AH, Racchetti G, Podini P, Bole DG, Dunn WA, Pozzan T, Snyder SH, Meldolesi J
Neuroscience. 1992
PubMed ID: 1331857

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	821	12330	29144
EnsEMBL Gene(s)	ENSG00000127022	ENSMUSG00000020368	ENSRNOG00000003343
Unigene	Hs.567968	Mm.248827	Rn.1762
Homologene	CANX	Canx	Canx
OMIM	114217	N/A	N/A
GeneCards	CANX	N/A	N/A
Beta Cell Genomics	DT.100887015 DT.40116945 DT.450755 DT.91889830 DT.97865395	DT.101152166 DT.103575559 DT.94139258 DT.94209265 DT.99865571	N/A
Reactome	P27824	N/A	N/A
Plasma Peptide Atlas	ENSP00000247461	N/A	N/A
WikiGenes	821	12330	29144

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
CANX	HDAC5	BioGRID	empirical	21081666
CANX	PIGK	BioGRID	empirical	12582175
CANX	BCAP31	HPRD	empirical	11851433
CANX	EBI3	HPRD, BioGRID	empirical	8551575
CANX	NDRG1	HPRD, IntAct	empirical	17220478
CANX	CFTR	HPRD, MINT, IntAct	empirical	12208510 16546175 17110338
CANX	USP19	MINT	empirical	19465887
CANX	FAM107A	HPRD, MINT, IntAct	empirical	16169070
CANX	PRAF2	MINT	empirical	15757671
CANX	GABARAPL2	IntAct	empirical	20562859
CANX	ABCC2	HPRD	empirical	12222674
CANX	CSNK2A1	IntAct	empirical	22113938
CANX	ZNRF4	BioGRID	empirical	21205830
CANX	F8	HPRD, BioGRID	empirical	9525969
CANX	GABARAPL1	IntAct	empirical	20562859
CANX	FSHR	HPRD, MIPS	empirical	9528938
CANX	AMBN	IntAct	empirical	15883644
CANX	SVIP	BioGRID	empirical	17872946
CANX	TOR1AIP1	IntAct, BioGRID	empirical	20360068
CANX	BSCL2	BioGRID	empirical	17387721
CANX	AMFR	BioGRID	empirical	21343306
CANX	SERP1	HPRD	empirical	10601334
CANX	GRIA1	HPRD, MIPS	empirical	10461883
CANX	GRIA2	MIPS	empirical	10461883
CANX	GRIA3	MIPS	empirical	10461883
CANX	GRIN1	HPRD	empirical	14732708 11506858
CANX	PDIA3	HPRD, Reactome	empirical	10436013
CANX	HLA-A	HPRD	empirical	17467700
CANX	HTR3A	HPRD	empirical	12359150
CANX	APOB	HPRD, BioGRID	empirical	14498830 9765244
CANX	IFNGR1	HPRD	empirical	8136357
CANX	APP	IntAct	empirical	17934213
CANX	ITGA6	HPRD	empirical	8163531
CANX	ITGB1	BioGRID	empirical	8163531
CANX	CD82	HPRD	empirical	11350933
CANX	L1CAM	BioGRID	empirical	22222883
CANX	LCT	HPRD, BioGRID	empirical	11751874
CANX	LHCGR	HPRD, MIPS	empirical	9528938
CANX	LPA	HPRD, BioGRID	empirical	9717723 12562843
CANX	LRP1	HPRD, BioGRID	empirical	14980518
CANX	MTNR1A	HPRD, IntAct	empirical	17215244
CANX	MTNR1B	HPRD, IntAct	empirical	17215244
CANX	SEPSECS	Sanger Interaction Map	predicted	15345047
CANX	SERPINA1	MINT, MIPS	empirical	17380188 9065464 8125971
CANX	PLP1	HPRD	empirical	12805210
CANX	PMP22	HPRD	empirical	12119418
CANX	PRKCSH	HPRD	empirical	8910335
CANX	MAPK13	IntAct, BioGRID	empirical	19135240
CANX	TRPV4	IntAct	empirical	16293632
CANX	RPL7	MINT	empirical	17258209
CANX	SMURF2	HPRD, MINT	empirical	15231748
CANX	SLC2A1	HPRD	empirical	8662691
CANX	SLC2A4	IntAct	empirical	16396496
CANX	SLC4A1	HPRD, BioGRID	empirical	10364201
CANX	SSR1	MINT	empirical	17380188
CANX	TF	HPRD, BioGRID	empirical	9312001
CANX	TG	HPRD	empirical	10636893
CANX	TNF	IntAct	empirical	17623297
CANX	TNFRSF1A	MINT, IntAct	empirical	14743216 16680093
CANX	TSHR	HPRD, BioGRID	empirical	12383251
CANX	UBC	BioGRID	empirical	16196087 21205830 18781797 21139048 21890473 21906983
CANX	YWHAB	IntAct	empirical	16635246
CANX	YWHAZ	IntAct	empirical	19562802
CANX	CALR	BioGRID, Reactome	empirical	10436013
CANX	C11orf68	IntAct, BioGRID	empirical	20360068
CANX	IKBKG	MINT, IntAct	empirical	14743216
CANX	MBTPS1	HPRD	empirical	11756446
CANX	KSR1	IntAct	empirical	20679487
CANX	CD1D	HPRD	empirical	12239218
CANX	CD3D	HPRD, BioGRID	empirical	8621641 8278814
CANX	MAPK8IP1	IntAct	empirical	18286207
CANX	EDEM1	HPRD, BioGRID	empirical	12610305