CAMK2D

Summary Top Help

Gene Description:

calcium/calmodulin-dependent protein kinase II delta; calcium/calmodulin-dependent protein kinase II, delta

Synonyms:

8030469K03Rik, RATCAMKI, Camki, Camk2d, Camk2, CAMK2D, mKIAA4163, CAMKD, 2810011D23Rik, [d]-CaMKII, CAMK1

Orthologs:

Human CAMK2D (protein-coding), Mouse Camk2d (protein-coding), Rat Camk2d (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 2

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Iddm3	Rat	chr2:197256223..242256223	45.00	281

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm33	Rat	chr2:214633709..247295816	32.66	170

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr4:114372188..114683083 (310.89 kb) View in Genome Browser

(Mouse) NCBIM37 - chr3:126299220..126547972 (248.75 kb) View in Genome Browser

(Rat) RGSC3.4 - chr2:224019877..224111174 (91.30 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CAMK2D:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: We do not have expression data for this gene.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
			no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: We do not have tissue expression data for this gene.

Interactions Top Help

Interactions Table for CAMK2D:

The CAMK2D interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
CAMK2D	WASF3	IntAct	empirical	21988832
CAMK2D	STIP1	MINT	empirical	18486612
CAMK2D	CREM	HPRD	empirical	8404858
CAMK2D	CYLD	IntAct, BioGRID	empirical	19615732
CAMK2D	FAM171B	IntAct	empirical	21988832
CAMK2D	DLG4	IntAct	empirical	19455133
CAMK2D	EIF4B	MINT	empirical	18486612
CAMK2D	SPATA24	IntAct	empirical	21988832
CAMK2D	FLII	MINT	empirical	18588881
CAMK2D	ARL2BP	IntAct	empirical	21988832
CAMK2D	GRB2	IntAct	empirical	12577067
CAMK2D	GRIN2B	HPRD, MINT	empirical	16436603 16120608
CAMK2D	HNMT	IntAct	empirical	21988832
CAMK2D	IFNGR2	IntAct	empirical	21988832
CAMK2D	ARRB2	IntAct	empirical	17620599
CAMK2D	MAP2	MINT	empirical	18588881
CAMK2D	MYC	IntAct	empirical	21150319
CAMK2D	MAPK1	Sanger Interaction Map	predicted	15345047
CAMK2D	RPS4X	IntAct	empirical	21988832
CAMK2D	RPS18	HPRD, BioGRID	empirical	12145273
CAMK2D	SLC2A4	IntAct	empirical	16396496
CAMK2D	SNCA	IntAct	empirical	18614564
CAMK2D	STAT1	HPRD	empirical	11972023
CAMK2D	UBC	BioGRID	empirical	21139048 21890473 21906983
CAMK2D	VIM	HPRD	empirical	10852918 15345747
CAMK2D	CAMK2A	IntAct, BioGRID, Reactome	empirical	17353931 18218981 8615909
CAMK2D	CAMK2B	HPRD, Reactome	empirical	16185778 18218981 8615909
CAMK2D	CAMK2D	HPRD	empirical	17192257
CAMK2D	IKBKG	MINT, IntAct	empirical	14743216
CAMK2D	ACTN2	HPRD, MINT	empirical	16120608
CAMK2D	CD5	HPRD	empirical	9692886

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 13

Biocarta: None available

Reactome: 11

NCI-Nature Pathway Interaction Database: 2

Gene Ontology: 28

Publications from PubMed Top Help

Type 1 Diabetes Publications: 3

Publications: 145

PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome.
Mouton-Liger F, Thomas S, Rattenbach R, Magnol L, Larigaldie V, Ledru A, Herault Y, Verney C, Créau N
J Comp Neurol. 2011
PubMed ID: 21491429
Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice.
Yao L, Fan P, Jiang Z, Viatchenko-Karpinski S, Wu Y, Kornyeyev D, Hirakawa R, Budas GR, Rajamani S, Shryock JC, Belardinelli L
Am J Physiol Cell Physiol. 2011
PubMed ID: 21677263
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Ca²⁺ disorder caused by rapid electrical field stimulation can be modulated by CaMKIIδ expression in primary rat atrial myocytes.
Qin Y, Zhang Z, Chen J, Ding X, Tong S, Song Z
Biochem Biophys Res Commun. 2011
PubMed ID: 21575598
Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel alpha(1C)-subunit gene (Cacna1c) by DREAM translocation.
Ronkainen JJ, Hänninen SL, Korhonen T, Koivumäki JT, Skoumal R, Rautio S, Ronkainen VP, Tavi P
J Physiol. 2011
PubMed ID: 21486818
Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk.
Permuth-Wey J, Chen YA, Tsai YY, Chen Z, Qu X, Lancaster JM, Stockwell H, Dagne G, Iversen E, Risch H, Barnholtz-Sloan J, Cunningham JM, Vierkant RA, Fridley BL, Sutphen R, McLaughlin J, Narod SA, Goode EL, Schildkraut JM, Fenstermacher D, Phelan CM, Sellers TA
Cancer Epidemiol Biomarkers Prev. 2011
PubMed ID: 21447778
The δA isoform of calmodulin kinase II mediates pathological cardiac hypertrophy by interfering with the HDAC4-MEF2 signaling pathway.
Li C, Cai X, Sun H, Bai T, Zheng X, Zhou XW, Chen X, Gill DL, Li J, Tang XD
Biochem Biophys Res Commun. 2011
PubMed ID: 21554860
The multifunctional Ca2+/calmodulin-dependent kinase II delta (CaMKIIdelta) controls neointima formation after carotid ligation and vascular smooth muscle cell proliferation through cell cycle regulation by p21.
Li W, Li H, Sanders PN, Mohler PJ, Backs J, Olson EN, Anderson ME, Grumbach IM
J Biol Chem. 2011
PubMed ID: 21193397
Diastolic dysfunction and arrhythmias caused by overexpression of CaMKIIδ(C) can be reversed by inhibition of late Na(+) current.
Sossalla S, Maurer U, Schotola H, Hartmann N, Didié M, Zimmermann WH, Jacobshagen C, Wagner S, Maier LS
Basic Res Cardiol. 2011
PubMed ID: 21174213
SR proteins induce alternative exon skipping through their activities on the flanking constitutive exons.
Han J, Ding JH, Byeon CW, Kim JH, Hertel KJ, Jeong S, Fu XD
Mol Cell Biol. 2011
PubMed ID: 21135118
Overexpression of CaMKIIδc in RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and increased mortality.
Dybkova N, Sedej S, Napolitano C, Neef S, Rokita AG, Hünlich M, Brown JH, Kockskämper J, Priori SG, Pieske B, Maier LS
J Am Coll Cardiol. 2011
PubMed ID: 21251589
Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.
Shioda N, Beppu H, Fukuda T, Li E, Kitajima I, Fukunaga K
J Neurosci. 2011
PubMed ID: 21209221
Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development.
Bolte C, Zhang Y, Wang IC, Kalin TV, Molkentin JD, Kalinichenko VV
PLoS One. 2011
PubMed ID: 21779394
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Role of CaMKII in cardiovascular health, disease, and arrhythmia.
Mohler PJ, Hund TJ
Heart Rhythm. 2011
PubMed ID: 20673813
Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium.
Sossalla S, Fluschnik N, Schotola H, Ort KR, Neef S, Schulte T, Wittköpper K, Renner A, Schmitto JD, Gummert J, El-Armouche A, Hasenfuss G, Maier LS
Circ Res. 2010
PubMed ID: 20814023
Calcium/calmodulin kinase II-dependent acetylcholine receptor cycling at the mammalian neuromuscular junction in vivo.
Martinez-Pena y Valenzuela I, Mouslim C, Akaaboune M
J Neurosci. 2010
PubMed ID: 20844140
Polymorphisms in CACNA1E and Camk2d are associated with seizure susceptibility of Sprague-Dawley rats.
Rijkers K, Mescheriakova J, Majoie M, Lemmens E, van Wijk X, Philippens M, Van Kranen-Mastenbroek V, Schijns O, Vles J, Hoogland G
Epilepsy Res. 2010
PubMed ID: 20638246
Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy.
Toko H, Takahashi H, Kayama Y, Oka T, Minamino T, Okada S, Morimoto S, Zhan DY, Terasaki F, Anderson ME, Inoue M, Yao A, Nagai R, Kitaura Y, Sasaguri T, Komuro I
Circulation. 2010
PubMed ID: 20713897
Alterations of L-type calcium current and cardiac function in CaMKII{delta} knockout mice.
Xu L, Lai D, Cheng J, Lim HJ, Keskanokwong T, Backs J, Olson EN, Wang Y
Circ Res. 2010
PubMed ID: 20538682
Calcium/Calmodulin-dependent protein kinase II delta 6 (CaMKIIdelta6) and RhoA involvement in thrombin-induced endothelial barrier dysfunction.
Wang Z, Ginnan R, Abdullaev IF, Trebak M, Vincent PA, Singer HA
J Biol Chem. 2010
PubMed ID: 20442409
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure.
Kushnir A, Shan J, Betzenhauser MJ, Reiken S, Marks AR
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20479242
beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation.
Mangmool S, Shukla AK, Rockman HA
J Cell Biol. 2010
PubMed ID: 20421423
A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP
Hum Mol Genet. 2010
PubMed ID: 20332099
L-type Ca(2+) channel facilitation mediated by H(2)O(2)-induced activation of CaMKII in rat ventricular myocytes.
Song YH, Cho H, Ryu SY, Yoon JY, Park SH, Noh CI, Lee SH, Ho WK
J Mol Cell Cardiol. 2010
PubMed ID: 19883656
CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations.
Koval OM, Guan X, Wu Y, Joiner ML, Gao Z, Chen B, Grumbach IM, Luczak ED, Colbran RJ, Song LS, Hund TJ, Mohler PJ, Anderson ME
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20194790
Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice.
Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL, Bers DM, Brown JH
Circ Res. 2010
PubMed ID: 19959778
Calmodulin kinase II is required for angiotensin II-mediated vascular smooth muscle hypertrophy.
Li H, Li W, Gupta AK, Mohler PJ, Anderson ME, Grumbach IM
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 20023119
beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes.
Mani SK, Egan EA, Addy BK, Grimm M, Kasiganesan H, Thiyagarajan T, Renaud L, Brown JH, Kern CB, Menick DR
J Mol Cell Cardiol. 2010
PubMed ID: 19945464
The presence and activation of two essential transcription factors (cAMP response element-binding protein and cAMP-dependent transcription factor ATF1) in the two-cell mouse embryo.
Jin XL, O'Neill C
Biol Reprod. 2010
PubMed ID: 19776387
Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70.
Peng W, Zhang Y, Zheng M, Cheng H, Zhu W, Cao CM, Xiao RP
Circ Res. 2010
PubMed ID: 19910575
Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.
Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S
PLoS Biol. 2010
PubMed ID: 20668654
Alpha-kinase anchoring protein alphaKAP interacts with SERCA2A to spatially position Ca2+/calmodulin-dependent protein kinase II and modulate phospholamban phosphorylation.
Singh P, Salih M, Tuana BS
J Biol Chem. 2009
PubMed ID: 19671701
Critical role of nuclear calcium/calmodulin-dependent protein kinase IIdeltaB in cardiomyocyte survival in cardiomyopathy.
Little GH, Saw A, Bai Y, Dow J, Marjoram P, Simkhovich B, Leeka J, Kedes L, Kloner RA, Poizat C
J Biol Chem. 2009
PubMed ID: 19602725
Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
Oestrogen confers cardioprotection by suppressing Ca2+/calmodulin-dependent protein kinase II.
Ma Y, Cheng WT, Wu S, Wong TM
Br J Pharmacol. 2009
PubMed ID: 19422373
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
Ca/calmodulin kinase II differentially modulates potassium currents.
Wagner S, Hacker E, Grandi E, Weber SL, Dybkova N, Sossalla S, Sowa T, Fabritz L, Kirchhof P, Bers DM, Maier LS
Circ Arrhythm Electrophysiol. 2009
PubMed ID: 19808479
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
Ling H, Zhang T, Pereira L, Means CK, Cheng H, Gu Y, Dalton ND, Peterson KL, Chen J, Bers D, Heller Brown J
J Clin Invest. 2009
PubMed ID: 19381018
Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ
Mol Cell Proteomics. 2009
PubMed ID: 19131326
The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.
Backs J, Backs T, Neef S, Kreusser MM, Lehmann LH, Patrick DM, Grueter CE, Qi X, Richardson JA, Hill JA, Katus HA, Bassel-Duby R, Maier LS, Olson EN
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19179290
Cardiac ryanodine receptor phosphorylation by CaM Kinase II: keeping the balance right.
Currie S
Front Biosci. 2009
PubMed ID: 19482609
A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease.
Burgner D, Davila S, Breunis WB, Ng SB, Li Y, Bonnard C, Ling L, Wright VJ, Thalamuthu A, Odam M, Shimizu C, Burns JC, Levin M, Kuijpers TW, Hibberd ML, International Kawasaki Disease Genetics Consortium
PLoS Genet. 2009
PubMed ID: 19132087
Calcium/calmodulin-dependent phosphorylation of tumor protein D52 on serine residue 136 may be mediated by CAMK2delta6.
Chew CS, Chen X, Zhang H, Berg EA, Zhang H
Am J Physiol Gastrointest Liver Physiol. 2008
PubMed ID: 18832449
CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes.
Yip MF, Ramm G, Larance M, Hoehn KL, Wagner MC, Guilhaus M, James DE
Cell Metab. 2008
PubMed ID: 19046570
Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions.
McFarland MA, Ellis CE, Markey SP, Nussbaum RL
Mol Cell Proteomics. 2008
PubMed ID: 18614564
kappa-Opioid receptor stimulation inhibits augmentation of Ca(2+) transient and hypertrophy induced by isoprenaline in neonatal rat ventricular myocytes - Role of CaMKIIdelta(B).
Wu G, Wang H, Yang J, Yang Y, Liu C, Jing L, Wong TM
Eur J Pharmacol. 2008
PubMed ID: 18721804
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry.
Forsman A, Rüetschi U, Ekholm J, Rymo L
J Proteome Res. 2008
PubMed ID: 18457437
CaM kinase II delta2-dependent regulation of vascular smooth muscle cell polarization and migration.
Mercure MZ, Ginnan R, Singer HA
Am J Physiol Cell Physiol. 2008
PubMed ID: 18385282
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation.
Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, O'Donnell SE, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham AJ, Weiss RM, Spitz DR, Shea MA, Colbran RJ, Mohler PJ, Anderson ME
Cell. 2008
PubMed ID: 18455987
Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
Han G, Ye M, Zhou H, Jiang X, Feng S, Jiang X, Tian R, Wan D, Zou H, Gu J
Proteomics. 2008
PubMed ID: 18318008
Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation.
Correia SS, Bassani S, Brown TC, Lisé MF, Backos DS, El-Husseini A, Passafaro M, Esteban JA
Nat Neurosci. 2008
PubMed ID: 18311135
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure.
Bossuyt J, Helmstadter K, Wu X, Clements-Jewery H, Haworth RS, Avkiran M, Martin JL, Pogwizd SM, Bers DM
Circ Res. 2008
PubMed ID: 18218981
CaMKII-delta isoform regulation of neointima formation after vascular injury.
House SJ, Singer HA
Arterioscler Thromb Vasc Biol. 2008
PubMed ID: 18096823
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
Ballif BA, Carey GR, Sunyaev SR, Gygi SP
J Proteome Res. 2008
PubMed ID: 18034455
Effects on recovery during acidosis in cardiac myocytes overexpressing CaMKII.
Sag CM, Dybkova N, Neef S, Maier LS
J Mol Cell Cardiol. 2007
PubMed ID: 17950750
The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming.
Cohen TJ, Waddell DS, Barrientos T, Lu Z, Feng G, Cox GA, Bodine SC, Yao TP
J Biol Chem. 2007
PubMed ID: 17873280
Interaction of calcium/calmodulin-dependent protein kinase IIdeltaC with sorcin indirectly modulates ryanodine receptor function in cardiac myocytes.
Anthony DF, Beattie J, Paul A, Currie S
J Mol Cell Cardiol. 2007
PubMed ID: 17707398
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
iNOS regulation by calcium/calmodulin-dependent protein kinase II in vascular smooth muscle.
Jones RJ, Jourd'heuil D, Salerno JC, Smith SM, Singer HA
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17293490
Calcium/calmodulin-dependent protein kinase II-delta isoform regulation of vascular smooth muscle cell proliferation.
House SJ, Ginnan RG, Armstrong SE, Singer HA
Am J Physiol Cell Physiol. 2007
PubMed ID: 17267544
Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells.
Liu Y, Templeton DM
FEBS Lett. 2007
PubMed ID: 17367784
Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells.
Little GH, Bai Y, Williams T, Poizat C
J Biol Chem. 2007
PubMed ID: 17179159
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H
Mol Cell Proteomics. 2007
PubMed ID: 17192257
Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart.
Maier LS, Bers DM
Cardiovasc Res. 2007
PubMed ID: 17157285
Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes.
Yang D, Zhu WZ, Xiao B, Brochet DX, Chen SR, Lakatta EG, Xiao RP, Cheng H
Circ Res. 2007
PubMed ID: 17234969
Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels.
Wagner S, Dybkova N, Rasenack EC, Jacobshagen C, Fabritz L, Kirchhof P, Maier SK, Zhang T, Hasenfuss G, Brown JH, Bers DM, Maier LS
J Clin Invest. 2006
PubMed ID: 17124532
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy.
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J Physiol. 2006
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J Neurosci. 2006
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Genome Res. 2006
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Distinct role of calmodulin and calmodulin-dependent protein kinase-II in lipopolysaccharide and tumor necrosis factor-alpha-mediated suppression of apoptosis and antiapoptotic c-IAP2 gene expression in human monocytic cells.
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J Biol Chem. 2005
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Biochim Biophys Acta. 2005
PubMed ID: 16185778
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J Biol Chem. 2005
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Science. 2005
PubMed ID: 16141073
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Science. 2005
PubMed ID: 16141072
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
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Nature. 2005
PubMed ID: 15815621
Calmodulin kinase II inhibition protects against structural heart disease.
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Nat Med. 2005
PubMed ID: 15793582
Calcium/calmodulin dependent protein kinase II regulates the phosphorylation of cyclic AMP-responsive element-binding protein of spinal cord in rats following noxious stimulation.
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Neurosci Lett. 2005
PubMed ID: 15631885
Regulation of Kv4.3 currents by Ca2+/calmodulin-dependent protein kinase II.
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Am J Physiol Cell Physiol. 2005
PubMed ID: 15456698
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle.
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Cell. 2005
PubMed ID: 15652482
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
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Nat Methods. 2004
PubMed ID: 15782199
Phosphoproteomic analysis of the developing mouse brain.
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Mol Cell Proteomics. 2004
PubMed ID: 15345747
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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Genome Res. 2004
PubMed ID: 15489334
Genomic analysis of mouse retinal development.
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PLoS Biol. 2004
PubMed ID: 15226823
Modulation of vascular smooth muscle cell migration by calcium/ calmodulin-dependent protein kinase II-delta 2.
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Am J Physiol Cell Physiol. 2004
PubMed ID: 14761894
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II.
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J Biol Chem. 2004
PubMed ID: 14722083
Complete sequencing and characterization of 21,243 full-length human cDNAs.
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Nat Genet. 2004
PubMed ID: 14702039
The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.
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Neuron. 2003
PubMed ID: 14622581
Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle.
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J Neurophysiol. 2003
PubMed ID: 12815021
Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle.
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Am J Physiol Cell Physiol. 2003
PubMed ID: 12660151
The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure.
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Circ Res. 2003
PubMed ID: 12676814
CaM kinase IIdeltaC phosphorylation of 14-3-3beta in vascular smooth muscle cells: activation of class II HDAC repression.
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Mol Cell Biochem. 2003
PubMed ID: 12619878
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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Nature. 2002
PubMed ID: 12466851
Axonal localization of delta Ca2+/calmodulin-dependent protein kinase II in developing P19 neurons.
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Int J Dev Neurosci. 2002
PubMed ID: 12526889
The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II.
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J Biol Chem. 2002
PubMed ID: 12145273
Calcium/calmodulin-dependent protein kinase IIdelta 2 and gamma isoforms regulate potassium currents of rat brain capillary endothelial cells under hypoxic conditions.
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J Biol Chem. 2002
PubMed ID: 11925434
Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.
Nair JS, DaFonseca CJ, Tjernberg A, Sun W, Darnell JE, Chait BT, Zhang JJ
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11972023
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Tanpakushitsu Kakusan Koso. 2002
PubMed ID: 11889801
The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity.
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J Biol Chem. 2002
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Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
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Genome Res. 2001
PubMed ID: 11544199
Functional annotation of a full-length mouse cDNA collection.
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Nature. 2001
PubMed ID: 11217851
Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding protein.
Wu X, McMurray CT
J Biol Chem. 2001
PubMed ID: 11013247
Ca(2+)/CaM-dependent kinases: from activation to function.
Hook SS, Means AR
Annu Rev Pharmacol Toxicol. 2001
PubMed ID: 11264466
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Activation of Ca2+/calmodulin-dependent protein kinase II within post-synaptic dendritic spines of cultured hippocampal neurons.
Inagaki N, Nishizawa M, Arimura N, Yamamoto H, Takeuchi Y, Miyamoto E, Kaibuchi K, Inagaki M
J Biol Chem. 2000
PubMed ID: 10852918
delta-Ca(2+)/calmodulin-dependent protein kinase II expression pattern in adult mouse heart and cardiogenic differentiation of embryonic stem cells.
Hoch B, Wobus AM, Krause EG, Karczewski P
J Cell Biochem. 2000
PubMed ID: 10967556
Downregulation of delta CaM kinase II in human tumor cells.
Tombes RM, Mikkelsen RB, Jarvis WD, Grant S
Biochim Biophys Acta. 1999
PubMed ID: 10525155
Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.
Anborgh PH, Qian X, Papageorge AG, Vass WC, DeClue JE, Lowy DR
Mol Cell Biol. 1999
PubMed ID: 10373510
Developmental expression of the CaM kinase II isoforms: ubiquitous gamma- and delta-CaM kinase II are the early isoforms and most abundant in the developing nervous system.
Bayer KU, Löhler J, Schulman H, Harbers K
Brain Res Mol Brain Res. 1999
PubMed ID: 10381553
Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium.
Hoch B, Meyer R, Hetzer R, Krause EG, Karczewski P
Circ Res. 1999
PubMed ID: 10189359
Nuclear localization of the delta subunit of Ca2+/calmodulin-dependent protein kinase II in rat cerebellar granule cells.
Takeuchi Y, Yamamoto H, Matsumoto K, Kimura T, Katsuragi S, Miyakawa T, Miyamoto E
J Neurochem. 1999
PubMed ID: 9930758
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Toward a complete human genome sequence.

Genome Res. 1998
PubMed ID: 9847074
Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution.
Szpirer C, Szpirer J, Van Vooren P, Tissir F, Simon JS, Koike G, Jacob HJ, Lander ES, Helou K, Klinga-Levan K, Levan G
Mamm Genome. 1998
PubMed ID: 9716657
Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta.
Bauch A, Campbell KS, Reth M
Eur J Immunol. 1998
PubMed ID: 9692886
Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+.
Wollmuth LP, Kuner T, Sakmann B
J Physiol. 1998
PubMed ID: 9481670
Mapping of rat chromosome 2 markers generated from chromosome-sorted DNA.
Deng AY, Jackson CM, Hoebee B, Rapp JP
Mamm Genome. 1997
PubMed ID: 9321465
Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II.
Moyers JS, Bilan PJ, Zhu J, Kahn CR
J Biol Chem. 1997
PubMed ID: 9115241
Identification of novel human tumor cell-specific CaMK-II variants.
Tombes RM, Krystal GW
Biochim Biophys Acta. 1997
PubMed ID: 9060999
Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cel
Williams CL, Phelps SH, Porter RA
Biochem Pharmacol. 1996
PubMed ID: 8615909
Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestation.
Andersen DL, Tannenberg AE, Burke CJ, Dodd PR
Brain Res Dev Brain Res. 1995
PubMed ID: 8665664
Novel and uncommon isoforms of the calcium sensing enzyme calcium/calmodulin dependent protein kinase II in heart tissue.
Mayer P, Möhlig M, Idlibe D, Pfeiffer A
Basic Res Cardiol. 1995
PubMed ID: 8585858
Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.
Deng AY, Dene H, Rapp JP
J Clin Invest. 1994
PubMed ID: 8040284
Identification and characterization of delta B-CaM kinase and delta C-CaM kinase from rat heart, two new multifunctional Ca2+/calmodulin-dependent protein kinase isoforms.
Edman CF, Schulman H
Biochim Biophys Acta. 1994
PubMed ID: 8130281
New isoforms of multifunctional calcium/calmodulin-dependent protein kinase II.
Mayer P, Möhlig M, Schatz H, Pfeiffer A
FEBS Lett. 1993
PubMed ID: 8224201
Multiple and cooperative phosphorylation events regulate the CREM activator function.
de Groot RP, den Hertog J, Vandenheede JR, Goris J, Sassone-Corsi P
EMBO J. 1993
PubMed ID: 8404858
Identification of novel isoforms of the delta subunit of Ca2+/calmodulin-dependent protein kinase II. Differential expression in rat brain and aorta.
Schworer CM, Rothblum LI, Thekkumkara TJ, Singer HA
J Biol Chem. 1993
PubMed ID: 8390994
Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs.
Tobimatsu T, Fujisawa H
J Biol Chem. 1989
PubMed ID: 2553697

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	817	108058	24246
EnsEMBL Gene(s)	ENSG00000145349	ENSMUSG00000053819	ENSRNOG00000011589
Unigene	Hs.144114	Mm.255822	Rn.87208
Homologene	CAMK2D	Camk2d	Camk2d
OMIM	607708	N/A	N/A
GeneCards	CAMK2D	N/A	N/A
Beta Cell Genomics	DT.100026499 DT.100787058 DT.100787059 DT.100787061 DT.318204 DT.454654	DT.101299356 DT.101354893 DT.101399576 DT.527906 DT.55242332 DT.87025868 DT.91409751 DT.91445949 DT.91553373 DT.91564938 DT.94131845 DT.94278361 DT.94278363 DT.94278406 DT.97402707	N/A
Reactome	Q13557	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	817	108058	24246

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