COIL

Summary Top Help

Gene Description:

coilin

Synonyms:

p80-coilin, CLN80, C79982, COIL, Coil, Cln80

Orthologs:

Human COIL (protein-coding), Mouse Coil (protein-coding), Rat Coil (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr17:55015560..55038411 (22.85 kb) View in Genome Browser

(Mouse) NCBIM37 - chr11:88831566..88852927 (21.36 kb) View in Genome Browser

(Rat) RGSC3.4 - chr10:77435825..77452170 (16.34 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for COIL:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for COIL:

The COIL interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
COIL	CDK2	HPRD	empirical	11102515
COIL	PSME3	HPRD, MINT, IntAct	empirical	16713569
COIL	MYBBP1A	IntAct	empirical	19928837
COIL	ZNF277	HPRD, MINT, IntAct	empirical	16713569
COIL	CSNK2B	HPRD, MINT, IntAct	empirical	16713569
COIL	ESR2	IntAct	empirical	21182203
COIL	HABP4	MINT	empirical	19523114
COIL	KAZN	HPRD, IntAct	empirical	16713569
COIL	XRCC6	BioGRID	empirical	21070772
COIL	PLEKHG4	HPRD, MINT, IntAct	empirical	16713569
COIL	PRMT1	HPRD, MINT, IntAct	empirical	16713569
COIL	KPNA3	HPRD, MINT, IntAct	empirical	16713569
COIL	MYO5B	HPRD, MINT, IntAct	empirical	16713569
COIL	NHP2L1	BioGRID	empirical	20360068
COIL	TCEB3B	HPRD, MINT, IntAct	empirical	16713569
COIL	PIAS4	HPRD	empirical	16219678
COIL	CYB5R2	HPRD, MINT, IntAct	empirical	16713569
COIL	WDYHV1	HPRD, MINT, IntAct	empirical	16713569
COIL	PRMT8	HPRD, MINT, IntAct	empirical	16713569
COIL	PSMA1	HPRD, MINT, IntAct	empirical	16713569
COIL	SCYL1	HPRD, MINT, IntAct	empirical	16713569
COIL	KLHDC5	HPRD, MINT, IntAct	empirical	16713569
COIL	KLHL8	HPRD, MINT, IntAct	empirical	16713569
COIL	SNX6	HPRD, MINT, IntAct	empirical	16713569
COIL	NIF3L1	HPRD, MINT, IntAct	empirical	16713569
COIL	ATXN1	HPRD, MINT, IntAct, BioGRID	empirical	12757932 16713569 18439907
COIL	TSPYL2	HPRD, MINT, IntAct	empirical	16713569
COIL	CCDC136	HPRD, IntAct	empirical	16713569
COIL	KLC2	HPRD, MINT, IntAct	empirical	16713569
COIL	SMN1	HPRD	empirical	12361597 11641277
COIL	SNRPB	HPRD, BioGRID	empirical	11641277
COIL	TAF9	HPRD, MINT, IntAct	empirical	16079131 16713569
COIL	TFCP2	HPRD, MINT, IntAct	empirical	16713569
COIL	BYSL	HPRD, MINT, IntAct	empirical	16713569
COIL	C1QBP	HPRD, MINT, IntAct	empirical	16713569
COIL	UBC	BioGRID	empirical	22178446 21139048 21890473 21906983
COIL	VRK1	IntAct	empirical	21920476
COIL	VRK2	IntAct	empirical	21920476
COIL	XRCC5	BioGRID	empirical	21070772
COIL	ZBTB25	HPRD, MINT, IntAct	empirical	16713569
COIL	GCC1	HPRD, MINT, IntAct	empirical	16713569
COIL	NUDT18	HPRD, MINT, IntAct	empirical	16713569
COIL	CEP76	HPRD, MINT, IntAct	empirical	16713569
COIL	CEP70	HPRD, MINT, IntAct	empirical	16713569
COIL	ACTN4	HPRD, MINT, IntAct	empirical	16713569
COIL	COIL	HPRD, MINT, IntAct, BioGRID	empirical	11102515 16713569
COIL	MAD1L1	HPRD, MINT, IntAct	empirical	16713569
COIL	DHX16	HPRD, MINT, IntAct	empirical	16713569
COIL	LNX1	HPRD, MINT, IntAct	empirical	16713569
COIL	ACTN1	HPRD, MINT, IntAct	empirical	16713569
COIL	ACTN2	HPRD, MINT, IntAct	empirical	16713569
COIL	CCNE1	HPRD, BioGRID	empirical	10751146
COIL	KLC4	HPRD, MINT, IntAct	empirical	16713569
COIL	KALRN	HPRD, MINT, IntAct	empirical	16713569
COIL	DNAJA3	HPRD, MINT, IntAct	empirical	16713569
COIL	NOLC1	HPRD, MIPS, BioGRID	empirical	9679133
COIL	FHL5	HPRD, MINT, IntAct	empirical	16713569
COIL	PICK1	HPRD, MINT, IntAct	empirical	16713569
COIL	FXR2	HPRD, MINT, IntAct	empirical	16713569
COIL	PREPL	HPRD, MINT, IntAct	empirical	16713569
COIL	TGS1	HPRD, MINT, IntAct	empirical	16713569
COIL	SART3	HPRD, MINT, IntAct	empirical	16713569
COIL	FAM115A	HPRD, MINT, IntAct	empirical	16713569

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 10

Publications from PubMed Top Help

Publications: 83

Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs).
Lopitz-Otsoa F, Rodriguez-Suarez E, Aillet F, Casado-Vela J, Lang V, Matthiesen R, Elortza F, Rodriguez MS
J Proteomics. 2011
PubMed ID: 22178446
Coilin participates in the suppression of RNA polymerase I in response to cisplatin-induced DNA damage.
Gilder AS, Do PM, Carrero ZI, Cosman AM, Broome HJ, Velma V, Martinez LA, Hebert MD
Mol Biol Cell. 2011
PubMed ID: 21289084
Coilin phosphomutants disrupt Cajal body formation, reduce cell proliferation and produce a distinct coilin degradation product.
Carrero ZI, Velma V, Douglas HE, Hebert MD
PLoS One. 2011
PubMed ID: 21991343
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Coilin interacts with Ku proteins and inhibits in vitro non-homologous DNA end joining.
Velma V, Carrero ZI, Cosman AM, Hebert MD
FEBS Lett. 2010
PubMed ID: 21070772
Solution structure of the carboxy-terminal Tudor domain from human Coilin.
Shanbhag R, Kurabi A, Kwan JJ, Donaldson LW
FEBS Lett. 2010
PubMed ID: 20875822
Nucleolar targeting of coilin is regulated by its hypomethylation state.
Tapia O, Bengoechea R, Berciano MT, Lafarga M
Chromosoma. 2010
PubMed ID: 20449600
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
Coilin phosphorylation mediates interaction with SMN and SmB'.
Toyota CG, Davis MD, Cosman AM, Hebert MD
Chromosoma. 2010
PubMed ID: 19997741
The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
Zhao J, Li M, Bradfield JP, Zhang H, Mentch FD, Wang K, Sleiman PM, Kim CE, Glessner JT, Hou C, Keating BJ, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Chiavacci RM, Berkowitz RI, Hakonarson H, Grant SF
BMC Med Genet. 2010
PubMed ID: 20546612
Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines.
Hearst SM, Gilder AS, Negi SS, Davis MD, George EM, Whittom AA, Toyota CG, Husedzinovic A, Gruss OJ, Hebert MD
J Cell Sci. 2009
PubMed ID: 19435804
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
The unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome.
Hao L, Vassena R, Wu G, Han Z, Cheng Y, Latham KE, Sapienza C
Biol Reprod. 2009
PubMed ID: 19129515
Reduced viability, fertility and fecundity in mice lacking the cajal body marker protein, coilin.
Walker MP, Tian L, Matera AG
PLoS One. 2009
PubMed ID: 19587784
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy.
Bongiorno-Borbone L, De Cola A, Vernole P, Finos L, Barcaroli D, Knight RA, Melino G, De Laurenzi V
Cell Cycle. 2008
PubMed ID: 18677100
UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1.
Hong S, Lee S, Cho SG, Kang S
Biochem Biophys Res Commun. 2008
PubMed ID: 18439907
Many sequence variants affecting diversity of adult human height.
Gudbjartsson DF, Walters GB, Thorleifsson G, Stefansson H, Halldorsson BV, Zusmanovich P, Sulem P, Thorlacius S, Gylfason A, Steinberg S, Helgadottir A, Ingason A, Steinthorsdottir V, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Borch-Johnsen K, Hansen T, Andersen G, Jorgensen T, Pedersen O, Aben KK, Witjes JA, Swinkels DW, den Heijer M, Franke B, Verbeek AL, Becker DM, Yanek LR, Becker LC, Tryggvadottir L, Rafnar T, Gulcher J, Kiemeney LA, Kong A, Thorsteinsdottir U, Stefansson K
Nat Genet. 2008
PubMed ID: 18391951
Coilin levels and modifications influence artificial reporter splicing.
Whittom AA, Xu H, Hebert MD
Cell Mol Life Sci. 2008
PubMed ID: 18322647
[Nucleolus transformation in oocytes of mouse antral follicles. Revealing of coilin and RNA polymerase I complex components]
Pochukalina GN, Parfenov VN
Tsitologiia. 2008
PubMed ID: 18822787
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing.
Miele A, Medina R, van Wijnen AJ, Stein GS, Stein JL
J Cell Biochem. 2007
PubMed ID: 17577209
Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2.
Dunphy JL, Ye K, Casanova JE
Traffic. 2007
PubMed ID: 17461797
LAP2alpha-binding protein LINT-25 is a novel chromatin-associated protein involved in cell cycle exit.
Naetar N, Hutter S, Dorner D, Dechat T, Korbei B, Gotzmann J, Beug H, Foisner R
J Cell Sci. 2007
PubMed ID: 17284516
Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.
Molina H, Horn DM, Tang N, Mathivanan S, Pandey A
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17287340
UV-induced fragmentation of Cajal bodies.
Cioce M, Boulon S, Matera AG, Lamond AI
J Cell Biol. 2006
PubMed ID: 17088425
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Implication of nucleolar protein SURF6 in ribosome biogenesis and preimplantation mouse development.
Romanova LG, Anger M, Zatsepina OV, Schultz RM
Biol Reprod. 2006
PubMed ID: 16855206
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP
Nat Biotechnol. 2006
PubMed ID: 16964243
Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies.
Lemm I, Girard C, Kuhn AN, Watkins NJ, Schneider M, Bordonné R, Lührmann R
Mol Biol Cell. 2006
PubMed ID: 16687569
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY
Cell. 2006
PubMed ID: 16713569
Phosphoproteome analysis of the human mitotic spindle.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16565220
Interactions between coilin and PIASy partially link Cajal bodies to PML bodies.
Sun J, Xu H, Subramony SH, Hebert MD
J Cell Sci. 2005
PubMed ID: 16219678
Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus.
Santama N, Ogg SC, Malekkou A, Zographos SE, Weis K, Lamond AI
J Biol Chem. 2005
PubMed ID: 16079131
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin.
Xu H, Hebert MD
BMC Cell Biol. 2005
PubMed ID: 15862129
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15302935
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Complete sequencing and characterization of 21,243 full-length human cDNAs.
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Nat Genet. 2004
PubMed ID: 14702039
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
p80 coilin, a coiled body-specific protein, interacts with ataxin-1, the SCA1 gene product.
Hong S, Ka S, Kim S, Park Y, Kang S
Biochim Biophys Acta. 2003
PubMed ID: 12757932
Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo.
Sleeman JE, Trinkle-Mulcahy L, Prescott AR, Ogg SC, Lamond AI
J Cell Sci. 2003
PubMed ID: 12679382
Control of Cajal body number is mediated by the coilin C-terminus.
Shpargel KB, Ospina JK, Tucker KE, Matera AG, Hebert MD
J Cell Sci. 2003
PubMed ID: 12482916
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Coilin methylation regulates nuclear body formation.
Hebert MD, Shpargel KB, Ospina JK, Tucker KE, Matera AG
Dev Cell. 2002
PubMed ID: 12361597
'Srcasm: a novel Src activating and signaling molecule.
Seykora JT, Mei L, Dotto GP, Stein PL
J Biol Chem. 2002
PubMed ID: 11711534
Directed proteomic analysis of the human nucleolus.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI
Curr Biol. 2002
PubMed ID: 11790298
snRNP protein expression enhances the formation of Cajal bodies containing p80-coilin and SMN.
Sleeman JE, Ajuh P, Lamond AI
J Cell Sci. 2001
PubMed ID: 11792806
Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein.
Hebert MD, Szymczyk PW, Shpargel KB, Matera AG
Genes Dev. 2001
PubMed ID: 11641277
Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product.
Tucker KE, Berciano MT, Jacobs EY, LePage DF, Shpargel KB, Rossire JJ, Chan EK, Lafarga M, Conlon RA, Matera AG
J Cell Biol. 2001
PubMed ID: 11470819
Nopp 140 involvement in nucleologenesis of mouse preimplantation embryos.
Baran V, Brochard V, Renard JP, Flechon JE
Mol Reprod Dev. 2001
PubMed ID: 11424213
Nuclear gems and Cajal (coiled) bodies in fetal tissues: nucleolar distribution of the spinal muscular atrophy protein, SMN.
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Exp Cell Res. 2001
PubMed ID: 11302690
Functional annotation of a full-length mouse cDNA collection.
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Nature. 2001
PubMed ID: 11217851
Self-association of coilin reveals a common theme in nuclear body localization.
Hebert MD, Matera AG
Mol Biol Cell. 2000
PubMed ID: 11102515
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
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Genome Res. 2000
PubMed ID: 11042159
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Cell cycle-dependent localization of the CDK2-cyclin E complex in Cajal (coiled) bodies.
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J Cell Sci. 2000
PubMed ID: 10751146
Structure and characterization of the murine p80 coilin gene, Coil.
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J Struct Biol. 2000
PubMed ID: 10806077
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
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Development. 2000
PubMed ID: 10725249
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Nopp140 functions as a molecular link between the nucleolus and the coiled bodies.
Isaac C, Yang Y, Meier UT
J Cell Biol. 1998
PubMed ID: 9679133
Dynamics of distribution of splicing components relative to the transcriptional state of human oocytes from antral follicles.
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J Cell Biochem. 1998
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[Splicing factors in oocyte nuclei from human antral follicles]
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Tsitologiia. 1998
PubMed ID: 9644758
Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.
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Genome Res. 1997
PubMed ID: 9371744
Inhibition of protein dephosphorylation results in the accumulation of splicing snRNPs and coiled bodies within the nucleolus.
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Exp Cell Res. 1997
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Normalization and subtraction: two approaches to facilitate gene discovery.
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Genome Res. 1996
PubMed ID: 8889548
Mutational analysis of p80 coilin indicates a functional interaction between coiled bodies and the nucleolus.
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J Cell Biol. 1995
PubMed ID: 7490287
Assignment of a human autoimmune antigen, p80-coilin gene to chromosome 17q21-q23 and of its possible pseudogene to chromosome 14.
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Hum Genet. 1995
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The biogenesis of the coiled body during early mouse development.
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Development. 1995
PubMed ID: 7768196
Rapid cDNA sequencing in combination with RNA expression studies in mice identifies a large number of male germ cell-specific sequence tags.
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Biol Reprod. 1995
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Structure, expression and chromosomal localization of human p80-coilin gene.
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Nucleic Acids Res. 1994
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Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.
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Genomics. 1994
PubMed ID: 7829101
Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis--evidence that the coiled body is a kinetic nuclear structure.
Carmo-Fonseca M, Ferreira J, Lamond AI
J Cell Biol. 1993
PubMed ID: 7679389
Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin.
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J Exp Med. 1991
PubMed ID: 2033369

Model Organism Phenotype Links from MGI Top Help

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	Human	Mouse	Rat
Entrez Gene	8161	12812	50998
EnsEMBL Gene(s)	ENSG00000121058	ENSMUSG00000033983	ENSRNOG00000000244
Unigene	Hs.532795	Mm.268004	Rn.203468
Homologene	COIL	Coil	Coil
OMIM	600272	N/A	N/A
GeneCards	COIL	N/A	N/A
Beta Cell Genomics	DT.117156	DT.101378647 DT.533476	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	8161	12812	50998

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