Home CAMK2A
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Regions Overlapping this Feature:
Rat: 1
Other Regions: 1 Available
Other Regions: 1 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes |
|---|---|---|---|---|
| Iddm35 | Rat | chr18:4320091..76880933 | 72.56 | 466 |
(Human) GRCh37 - chr5:149599054..149669854 (70.80 kb) View in Genome Browser
(Mouse) NCBIM37 - chr18:61085272..61147806 (62.53 kb) View in Genome Browser
(Rat) RGSC3.4 - chr18:56879247..56948537 (69.29 kb) View in Genome Browser
HaemAtlas Expression Table for CAMK2A:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for CAMK2A:The CAMK2A interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| CAMK2A | ABI1 | MINT, IntAct | empirical | 15102471 |
| CAMK2A | HDAC5 | BioGRID | empirical | 18292392 |
| CAMK2A | PDCD6IP | MINT, IntAct | empirical | 15102471 |
| CAMK2A | CEBPB | HPRD | empirical | 1314426 |
| CAMK2A | PAIP1 | MINT, IntAct | empirical | 15102471 |
| CAMK2A | YWHAQ | BioGRID | empirical | 18292392 |
| CAMK2A | CHAT | HPRD | empirical | 12486117 10861222 |
| CAMK2A | CPSF6 | MINT, IntAct | empirical | 15102471 |
| CAMK2A | CLTC | IntAct | empirical | 19562802 |
| CAMK2A | CREB1 | BioGRID | empirical | 8663317 |
| CAMK2A | PARP1 | BioGRID | empirical | 15607978 |
| CAMK2A | DLG1 | HPRD, BioGRID | empirical | 12933808 |
| CAMK2A | DLG3 | IntAct, BioGRID | empirical | 17353931 |
| CAMK2A | DLG4 | IntAct | empirical | 19455133 |
| CAMK2A | EGFR | HPRD | empirical | 1309762 10347170 |
| CAMK2A | NR2F6 | IntAct | empirical | 20195357 |
| CAMK2A | ETS1 | HPRD | empirical | 12475968 |
| CAMK2A | RIMS1 | BioGRID | empirical | 12871946 |
| CAMK2A | DAPK2 | HPRD | empirical | 10629061 |
| CAMK2A | RCHY1 | MINT, BioGRID | empirical | 17568776 |
| CAMK2A | GFAP | HPRD | empirical | 2155236 9099667 7822264 2114109 |
| CAMK2A | GRIA1 | MINT | empirical | 12536214 |
| CAMK2A | GRIA4 | MINT | empirical | 10366608 |
| CAMK2A | GIT1 | BioGRID | empirical | 18292392 |
| CAMK2A | GRIN1 | HPRD, MINT, IntAct | empirical | 10862698 16635246 |
| CAMK2A | GRIN2A | HPRD, MINT | empirical | 11104776 11222640 12147342 |
| CAMK2A | GRIN2B | HPRD, MINT, IntAct, BioGRID | empirical | 16436603 11306676 8940188 12147342 11459059 16120608 16710293 20141836 10862698 16635246 |
| CAMK2A | BLNK | MINT, IntAct | empirical | 15102471 |
| CAMK2A | HES1 | BioGRID | empirical | 15607978 |
| CAMK2A | HSF1 | HPRD | empirical | 11447121 |
| CAMK2A | IFIT3 | MINT, IntAct | empirical | 15102471 |
| CAMK2A | ITPKA | HPRD | empirical | 11468283 |
| CAMK2A | KPNB1 | MINT, IntAct | empirical | 15102471 |
| CAMK2A | KRT18 | HPRD | empirical | 7523419 1374067 |
| CAMK2A | SMAD2 | HPRD | empirical | 11027280 |
| CAMK2A | MAPT | HPRD, MINT | empirical | 9771888 9735171 10090741 9832145 12387894 7706316 8999860 10737616 12435421 17512525 |
| CAMK2A | ATF1 | BioGRID | empirical | 8663317 |
| CAMK2A | NOS1 | HPRD | empirical | 10400690 10874031 12630910 1375933 |
| CAMK2A | NOS3 | BioGRID | empirical | 11397791 |
| CAMK2A | ATP2A2 | HPRD | empirical | 7929371 |
| CAMK2A | PARK2 | BioGRID | empirical | 11679592 |
| CAMK2A | PDC | HPRD | empirical | 2394752 11331285 |
| CAMK2A | CHMP5 | IntAct, BioGRID | empirical | 17353931 |
| CAMK2A | PLCG1 | BioGRID | empirical | 18292392 |
| CAMK2A | PSMC1 | IntAct | empirical | 20178748 |
| CAMK2A | PSMC2 | IntAct | empirical | 20178748 |
| CAMK2A | PSMC4 | IntAct | empirical | 20178748 |
| CAMK2A | PSMC5 | IntAct | empirical | 20178748 |
| CAMK2A | LRRC7 | HPRD, MINT, BioGRID | empirical | 11160423 16120608 |
| CAMK2A | RAD23B | IntAct | empirical | 20178748 |
| CAMK2A | GPBP1 | MINT, IntAct | empirical | 15102471 |
| CAMK2A | SNCA | IntAct | empirical | 18614564 |
| CAMK2A | SRF | HPRD | empirical | 10753652 8413226 10318869 |
| CAMK2A | SYN1 | IntAct | empirical | 19562802 |
| CAMK2A | UBC | BioGRID | empirical | 21906983 |
| CAMK2A | YWHAB | IntAct, BioGRID | empirical | 16635246 12619878 |
| CAMK2A | BAG6 | MINT, IntAct | empirical | 15102471 |
| CAMK2A | ACTN4 | HPRD, BioGRID | empirical | 11160423 |
| CAMK2A | CAMK2A | HPRD, IntAct | empirical | 12408851 9452388 21884935 |
| CAMK2A | CAMK2B | MINT, IntAct, BioGRID | empirical | 17353931 15102471 |
| CAMK2A | CAMK2D | IntAct, BioGRID, Reactome | empirical | 17353931 18218981 8615909 |
| CAMK2A | CAMK2G | Reactome | predicted | 18218981 8615909 |
| CAMK2A | CAMLG | MINT, IntAct | empirical | 15102471 |
| CAMK2A | TANC1 | HPRD | empirical | 15673434 |
| CAMK2A | ACTN1 | HPRD, MINT | empirical | 12223541 16120608 |
| CAMK2A | MPDZ | HPRD | empirical | 15312654 |
| CAMK2A | ACTN2 | HPRD, MINT | empirical | 16120608 |
| CAMK2A | IQGAP1 | MINT, IntAct | empirical | 15102471 |
| CAMK2A | SYNGAP1 | HPRD | empirical | 15312654 12951199 11278737 15358237 14970204 |
| CAMK2A | CDK5R1 | HPRD, BioGRID | empirical | 12223541 |
| CAMK2A | CDK5R2 | HPRD, MINT | empirical | 12223541 |
| CAMK2A | ITGB1BP1 | HPRD | empirical | 9813144 |
| CAMK2A | CAMK2N2 | HPRD | empirical | 9724800 |
| CAMK2A | PPM1F | HPRD | empirical | 15140879 |
| CAMK2A | ARHGAP32 | BioGRID | empirical | 12531901 |
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Type 1 Diabetes Publications: 2
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Multiple kinases regulate mafA expression in the pancreatic beta cell line MIN6.
Vanderford NL, Cantrell JE, Popa GJ, Ozcan S
Arch Biochem Biophys. 2008
PubMed ID: 18948074
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A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKIIalpha (Thr286Asp) in pancreatic beta-cells.
Kato I, Oya T, Suzuki H, Takasawa K, Ichsan AM, Nakada S, Ishii Y, Shimada Y, Sasahara M, Tobe K, Takasawa S, Okamoto H, Hiraga K
Diabetes Metab Res Rev. 2008
PubMed ID: 18551708
Publications: 427
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CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death.
Chen S, Xu Y, Xu B, Guo M, Zhang Z, Liu L, Ma H, Chen Z, Luo Y, Huang S, Chen L
J Neurochem. 2011
PubMed ID: 21933187
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Mechanism for long-term memory formation when synaptic strengthening is impaired.
Radwanska K, Medvedev NI, Pereira GS, Engmann O, Thiede N, Moraes MF, Villers A, Irvine EE, Maunganidze NS, Pyza EM, Ris L, Szymańska M, Lipiński M, Kaczmarek L, Stewart MG, Giese KP
Proc Natl Acad Sci U S A. 2011
PubMed ID: 22025701
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Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers.
Mikl M, Vendra G, Kiebler MA
EMBO Rep. 2011
PubMed ID: 21869818
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PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome.
Mouton-Liger F, Thomas S, Rattenbach R, Magnol L, Larigaldie V, Ledru A, Herault Y, Verney C, Créau N
J Comp Neurol. 2011
PubMed ID: 21491429
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Oxidized CaMKII causes cardiac sinus node dysfunction in mice.
Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, He BJ, Luczak ED, Joiner ML, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM, Ogawa M, Chen PS, Efimov I, Dobrev D, Mohler PJ, Hund TJ, Anderson ME
J Clin Invest. 2011
PubMed ID: 21785215
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Loss of Thr286 phosphorylation disrupts synaptic CaMKIIα targeting, NMDAR activity and behavior in pre-adolescent mice.
Gustin RM, Shonesy BC, Robinson SL, Rentz TJ, Baucum AJ, Jalan-Sakrikar N, Winder DG, Stanwood GD, Colbran RJ
Mol Cell Neurosci. 2011
PubMed ID: 21627991
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Association of ADAM10 and CAMK2A polymorphisms with conduct disorder: evidence from family-based studies.
Jian XQ, Wang KS, Wu TJ, Hillhouse JJ, Mullersman JE
J Abnorm Child Psychol. 2011
PubMed ID: 21611732
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Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
Jiao Y, Jalan-Sakrikar N, Robison AJ, Baucum AJ, Bass MA, Colbran RJ
J Biol Chem. 2011
PubMed ID: 21610080
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βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses.
Borgesius NZ, van Woerden GM, Buitendijk GH, Keijzer N, Jaarsma D, Hoogenraad CC, Elgersma Y
J Neurosci. 2011
PubMed ID: 21752990
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Role of the CaMKII/NMDA receptor complex in the maintenance of synaptic strength.
Sanhueza M, Fernandez-Villalobos G, Stein IS, Kasumova G, Zhang P, Bayer KU, Otmakhov N, Hell JW, Lisman J
J Neurosci. 2011
PubMed ID: 21697368
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A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
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Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating.
Kristensen AS, Jenkins MA, Banke TG, Schousboe A, Makino Y, Johnson RC, Huganir R, Traynelis SF
Nat Neurosci. 2011
PubMed ID: 21516102
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Regional alterations of JNK3 and CaMKIIα subunit expression in the rat brain after soman poisoning.
Ramarao G, Waghmare C, Srivastava N, Bhattacharya B
Hum Exp Toxicol. 2011
PubMed ID: 21041242
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Calcium/calmodulin-dependent protein kinase II mediates group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus.
Mockett BG, Guévremont D, Wutte M, Hulme SR, Williams JM, Abraham WC
J Neurosci. 2011
PubMed ID: 21593322
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Conformational changes underlying calcium/calmodulin-dependent protein kinase II activation.
Hoffman L, Stein RA, Colbran RJ, Mchaourab HS
EMBO J. 2011
PubMed ID: 21343908
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Bidirectional control of BK channel open probability by CAMKII and PKC in medial vestibular nucleus neurons.
van Welie I, du Lac S
J Neurophysiol. 2011
PubMed ID: 21307321
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Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload.
Wagner S, Ruff HM, Weber SL, Bellmann S, Sowa T, Schulte T, Anderson ME, Grandi E, Bers DM, Backs J, Belardinelli L, Maier LS
Circ Res. 2011
PubMed ID: 21252154
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LTP in hippocampal neurons is associated with a CaMKII-mediated increase in GluA1 surface expression.
Appleby VJ, Corrêa SA, Duckworth JK, Nash JE, Noël J, Fitzjohn SM, Collingridge GL, Molnár E
J Neurochem. 2011
PubMed ID: 21143596
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Beta Ca2+/CaM-dependent kinase type II triggers upregulation of GluA1 to coordinate adaptation to synaptic inactivity in hippocampal neurons.
Groth RD, Lindskog M, Thiagarajan TC, Li L, Tsien RW
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21187407
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Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.
Shioda N, Beppu H, Fukuda T, Li E, Kitajima I, Fukunaga K
J Neurosci. 2011
PubMed ID: 21209221
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Properties of contextual memory formed in the absence of αCaMKII autophosphorylation.
Irvine EE, Danhiez A, Radwanska K, Nassim C, Lucchesi W, Godaux E, Ris L, Giese KP
Mol Brain. 2011
PubMed ID: 21276220
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Ca2+/calmodulin-dependent protein kinase II and protein kinase C activities mediate extracellular glucose-regulated hippocampal synaptic efficacy.
Moriguchi S, Oomura Y, Shioda N, Han F, Hori N, Aou S, Fukunaga K
Mol Cell Neurosci. 2011
PubMed ID: 20807573
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MicroRNA-148/152 impair innate response and antigen presentation of TLR-triggered dendritic cells by targeting CaMKIIα.
Liu X, Zhan Z, Xu L, Ma F, Li D, Guo Z, Li N, Cao X
J Immunol. 2010
PubMed ID: 21068402
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Selective translocation of Ca2+/calmodulin protein kinase IIalpha (CaMKIIalpha) to inhibitory synapses.
Marsden KC, Shemesh A, Bayer KU, Carroll RC
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21059908
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Hypothyroidism following developmental iodine deficiency reduces hippocampal neurogranin, CaMK II and calmodulin and elevates calcineurin in lactational rats.
Dong J, Liu W, Wang Y, Xi Q, Chen J
Int J Dev Neurosci. 2010
PubMed ID: 20654708
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A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice.
Hund TJ, Koval OM, Li J, Wright PJ, Qian L, Snyder JS, Gudmundsson H, Kline CF, Davidson NP, Cardona N, Rasband MN, Anderson ME, Mohler PJ
J Clin Invest. 2010
PubMed ID: 20877009
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Hyperactive mice show elevated D2(High) receptors, a model for schizophrenia: Calcium/calmodulin-dependent kinase II alpha knockouts.
Novak G, Seeman P
Synapse. 2010
PubMed ID: 20336626
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CaMKII control of spine size and synaptic strength: role of phosphorylation states and nonenzymatic action.
Pi HJ, Otmakhov N, El Gaamouch F, Lemelin D, De Koninck P, Lisman J
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20660727
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Alterations of L-type calcium current and cardiac function in CaMKII{delta} knockout mice.
Xu L, Lai D, Cheng J, Lim HJ, Keskanokwong T, Backs J, Olson EN, Wang Y
Circ Res. 2010
PubMed ID: 20538682
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NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1.
Guetg N, Aziz SA, Holbro N, Turecek R, Rose T, Seddik R, Gassmann M, Moes S, Jenoe P, Oertner TG, Casanova E, Bettler B
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20643921
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Effective post-insult neuroprotection by a novel Ca(2+)/ calmodulin-dependent protein kinase II (CaMKII) inhibitor.
Vest RS, O'Leary H, Coultrap SJ, Kindy MS, Bayer KU
J Biol Chem. 2010
PubMed ID: 20424167
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Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
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CaMKII hunkers down on the muscarinic M4 receptor to help curb cocaine-induced hyperlocomotion.
Stein IS, Hell JW
EMBO J. 2010
PubMed ID: 20551968
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CaMKIIalpha interacts with M4 muscarinic receptors to control receptor and psychomotor function.
Guo ML, Fibuch EE, Liu XY, Choe ES, Buch S, Mao LM, Wang JQ
EMBO J. 2010
PubMed ID: 20461055
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Facilitation of murine cardiac L-type Ca(v)1.2 channel is modulated by calmodulin kinase II-dependent phosphorylation of S1512 and S1570.
Blaich A, Welling A, Fischer S, Wegener JW, Köstner K, Hofmann F, Moosmang S
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20479240
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CaMKII regulates contraction- but not insulin-induced glucose uptake in mouse skeletal muscle.
Witczak CA, Jessen N, Warro DM, Toyoda T, Fujii N, Anderson ME, Hirshman MF, Goodyear LJ
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 20215576
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Effects of subchronic perfluorooctane sulfonate exposure of rats on calcium-dependent signaling molecules in the brain tissue.
Liu X, Liu W, Jin Y, Yu W, Liu L, Yu H
Arch Toxicol. 2010
PubMed ID: 20127074
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The signalling pathway of CaMKII-mediated apoptosis and necrosis in the ischemia/reperfusion injury.
Salas MA, Valverde CA, Sánchez G, Said M, Rodriguez JS, Portiansky EL, Kaetzel MA, Dedman JR, Donoso P, Kranias EG, Mattiazzi A
J Mol Cell Cardiol. 2010
PubMed ID: 20060004
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Interaction between Ca(v)2.1alpha (1) and CaMKII in Ca (v)2.1alpha (1) mutant mice, Rolling Nagoya.
Takahashi E, Niimi K, Itakura C
J Mol Neurosci. 2010
PubMed ID: 19609731
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Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function.
Skelding KA, Suzuki T, Gordon S, Xue J, Verrills NM, Dickson PW, Rostas JA
Cell Signal. 2010
PubMed ID: 20060891
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Ca2+-dependent facilitation of Cav1.3 Ca2+ channels by densin and Ca2+/calmodulin-dependent protein kinase II.
Jenkins MA, Christel CJ, Jiao Y, Abiria S, Kim KY, Usachev YM, Obermair GJ, Colbran RJ, Lee A
J Neurosci. 2010
PubMed ID: 20392935
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Structural plasticity underlies experience-dependent functional plasticity of cortical circuits.
Wilbrecht L, Holtmaat A, Wright N, Fox K, Svoboda K
J Neurosci. 2010
PubMed ID: 20371813
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Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II.
Pang ZP, Cao P, Xu W, Südhof TC
J Neurosci. 2010
PubMed ID: 20237283
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Involvement of calcium-calmodulin-dependent protein kinase II in endothelin receptor expression in rat cerebral arteries.
Waldsee R, Ahnstedt H, Eftekhari S, Edvinsson L
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 20008273
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Autophosphorylated CaMKIIalpha acts as a scaffold to recruit proteasomes to dendritic spines.
Bingol B, Wang CF, Arnott D, Cheng D, Peng J, Sheng M
Cell. 2010
PubMed ID: 20178748
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Calmodulin kinase II is required for angiotensin II-mediated vascular smooth muscle hypertrophy.
Li H, Li W, Gupta AK, Mohler PJ, Anderson ME, Grumbach IM
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 20023119
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The presence and activation of two essential transcription factors (cAMP response element-binding protein and cAMP-dependent transcription factor ATF1) in the two-cell mouse embryo.
Jin XL, O'Neill C
Biol Reprod. 2010
PubMed ID: 19776387
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CaM kinase II in colonic smooth muscle contributes to dysmotility in murine DSS-colitis.
Qureshi S, Song J, Lee HT, Koh SD, Hennig GW, Perrino BA
Neurogastroenterol Motil. 2010
PubMed ID: 19735476
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Ca2+/calmodulin-dependent protein kinase II alpha is required for the initiation and maintenance of opioid-induced hyperalgesia.
Chen Y, Yang C, Wang ZJ
J Neurosci. 2010
PubMed ID: 20053885
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Photounbinding of calmodulin from a family of CaM binding peptides.
Neumüller KG, Elsayad K, Reisecker JM, Waxham MN, Heinze KG
PLoS One. 2010
PubMed ID: 21124984
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The 14-3-3ζ protein binds to the cell adhesion molecule L1, promotes L1 phosphorylation by CKII and influences L1-dependent neurite outgrowth.
Ramser EM, Wolters G, Dityateva G, Dityatev A, Schachner M, Tilling T
PLoS One. 2010
PubMed ID: 20976158
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Depression of Ca(2+)/calmodulin-dependent protein kinase II in dorsal root ganglion neurons after spinal nerve ligation.
Kojundzic SL, Puljak L, Hogan Q, Sapunar D
J Comp Neurol. 2010
PubMed ID: 19882720
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A novel role for calcium/calmodulin kinase II within the brainstem pedunculopontine tegmentum for the regulation of wakefulness and rapid eye movement sleep.
Stack EC, Desarnaud F, Siwek DF, Datta S
J Neurochem. 2010
PubMed ID: 19860859
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CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation.
Abiria SA, Colbran RJ
J Neurochem. 2010
PubMed ID: 19840220
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CaMKIIalpha interacts with multi-PDZ domain protein MUPP1 in spermatozoa and prevents spontaneous acrosomal exocytosis.
Ackermann F, Zitranski N, Borth H, Buech T, Gudermann T, Boekhoff I
J Cell Sci. 2009
PubMed ID: 19934217
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Different role of cAMP dependent protein kinase and CaMKII in H3 receptor regulation of histamine synthesis and release.
Moreno-Delgado D, Gómez-Ramírez J, Torrent-Moreno A, González-Sepúlveda M, Blanco I, Ortiz J
Neuroscience. 2009
PubMed ID: 19735700
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The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag?
Okamoto K, Bosch M, Hayashi Y
Physiology (Bethesda). 2009
PubMed ID: 19996366
-
Alpha-kinase anchoring protein alphaKAP interacts with SERCA2A to spatially position Ca2+/calmodulin-dependent protein kinase II and modulate phospholamban phosphorylation.
Singh P, Salih M, Tuana BS
J Biol Chem. 2009
PubMed ID: 19671701
-
Time-dependent autoinactivation of phospho-Thr286-alphaCa2+/calmodulin-dependent protein kinase II.
Jama AM, Fenton J, Robertson SD, Török K
J Biol Chem. 2009
PubMed ID: 19654320
-
Constitutive CaMKII activity regulates Na+ channel in rat ventricular myocytes.
Yoon JY, Ho WK, Kim ST, Cho H
J Mol Cell Cardiol. 2009
PubMed ID: 19591836
-
Sustained depolarization decreases calcium/calmodulin-dependent protein kinase II activity and gene expression in dopamine neurons.
Padmanabhan S, Prasad BM
Neuroscience. 2009
PubMed ID: 19555740
-
Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II.
Djakovic SN, Schwarz LA, Barylko B, DeMartino GN, Patrick GN
J Biol Chem. 2009
PubMed ID: 19638347
-
Regulation of kinesin light chain 1 level correlates with the development of morphine reward in the mouse brain.
Bilecki W, Wawrzczak-Bargiela A, Przewłocki R
Eur J Neurosci. 2009
PubMed ID: 19735294
-
A role for calcium-calmodulin-dependent protein kinase II in the consolidation of visual object recognition memory.
Tinsley CJ, Narduzzo KE, Ho JW, Barker GR, Brown MW, Warburton EC
Eur J Neurosci. 2009
PubMed ID: 19735285
-
Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.
Yosifova A, Mushiroda T, Stoianov D, Vazharova R, Dimova I, Karachanak S, Zaharieva I, Milanova V, Madjirova N, Gerdjikov I, Tolev T, Velkova S, Kirov G, Owen MJ, O'Donovan MC, Toncheva D, Nakamura Y
J Affect Disord. 2009
PubMed ID: 19328558
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Acute inhibition of Ca2+/calmodulin-dependent protein kinase II reverses experimental neuropathic pain in mice.
Chen Y, Luo F, Yang C, Kirkmire CM, Wang ZJ
J Pharmacol Exp Ther. 2009
PubMed ID: 19478130
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BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV.
Kokubo M, Nishio M, Ribar TJ, Anderson KA, West AE, Means AR
J Neurosci. 2009
PubMed ID: 19605628
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Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.
Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XH
J Clin Invest. 2009
PubMed ID: 19603549
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Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice.
Moriguchi S, Han F, Shioda N, Yamamoto Y, Nakajima T, Nakagawasai O, Tadano T, Yeh JZ, Narahashi T, Fukunaga K
J Neurochem. 2009
PubMed ID: 19457128
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Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II.
Raveendran R, Devi Suma Priya S, Mayadevi M, Steephan M, Santhoshkumar TR, Cheriyan J, Sanalkumar R, Pradeep KK, James J, Omkumar RV
J Neurochem. 2009
PubMed ID: 19453375
-
Tissue and developmental regulation of fragile X mental retardation 1 exon 12 and 15 isoforms.
Xie W, Dolzhanskaya N, LaFauci G, Dobkin C, Denman RB
Neurobiol Dis. 2009
PubMed ID: 19362146
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Autophosphorylation of alphaCaMKII downregulates excitability of CA1 pyramidal neurons following synaptic stimulation.
Sametsky EA, Disterhoft JF, Ohno M
Neurobiol Learn Mem. 2009
PubMed ID: 19245842
-
Role of Ca2+/calmodulin-dependent protein kinase II in dendritic spine remodeling during epileptiform activity in vitro.
Zha XM, Dailey ME, Green SH
J Neurosci Res. 2009
PubMed ID: 19235894
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N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons.
Butcher AJ, Torrecilla I, Young KW, Kong KC, Mistry SC, Bottrill AR, Tobin AB
J Biol Chem. 2009
PubMed ID: 19332541
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Kinase-dead knock-in mouse reveals an essential role of kinase activity of Ca2+/calmodulin-dependent protein kinase IIalpha in dendritic spine enlargement, long-term potentiation, and learning.
Yamagata Y, Kobayashi S, Umeda T, Inoue A, Sakagami H, Fukaya M, Watanabe M, Hatanaka N, Totsuka M, Yagi T, Obata K, Imoto K, Yanagawa Y, Manabe T, Okabe S
J Neurosci. 2009
PubMed ID: 19515929
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Enhanced CaMKII activity and spatial cognitive function in SAMP6 mice.
Takahashi E, Niimi K, Itakura C
Behav Neurosci. 2009
PubMed ID: 19485558
-
Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1.
Fujiyama T, Yamada M, Terao M, Terashima T, Hioki H, Inoue YU, Inoue T, Masuyama N, Obata K, Yanagawa Y, Kawaguchi Y, Nabeshima Y, Hoshino M
Development. 2009
PubMed ID: 19439493
-
Activation of Ca2+/calmodulin-dependent protein kinase II alpha in the spinal cords of rats with clip compression injury.
Song MS, Seo HS, Yang M, Kim JS, Kim SH, Kim JC, Wang H, Sim KB, Kim H, Shin T, Moon C
Brain Res. 2009
PubMed ID: 19332038
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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{beta}-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+/calmodulin-dependent protein kinase II synaptic distribution.
Gu Z, Liu W, Yan Z
J Biol Chem. 2009
PubMed ID: 19240035
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Structural rearrangement of CaMKIIalpha catalytic domains encodes activation.
Thaler C, Koushik SV, Puhl HL, Blank PS, Vogel SS
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19339497
-
Improvement of depressive behaviors by nefiracetam is associated with activation of CaM kinases in olfactory bulbectomized mice.
Han F, Nakano T, Yamamoto Y, Shioda N, Lu YM, Fukunaga K
Brain Res. 2009
PubMed ID: 19233146
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Calmodulin kinase II is required for fight or flight sinoatrial node physiology.
Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19276108
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The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.
Sawallisch C, Berhörster K, Disanza A, Mantoani S, Kintscher M, Stoenica L, Dityatev A, Sieber S, Kindler S, Morellini F, Schweizer M, Boeckers TM, Korte M, Scita G, Kreienkamp HJ
J Biol Chem. 2009
PubMed ID: 19208628
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Phosphorylation of ribosomal protein S19 at Ser59 by CaM kinase I alpha.
Maeda N, Toku S, Naito Y, Nishiura H, Tanaka T, Yamamoto H
J Neurochem. 2009
PubMed ID: 19200342
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Selective blockade of CaMKII-alpha inhibits NMDA-induced caspase-3-dependent cell death but does not arrest PARP-1 activation or loss of plasma membrane selectivity in rat retinal neurons.
Goebel DJ
Brain Res. 2009
PubMed ID: 19135986
-
Selective inhibition of cyclooxygenase-2 attenuates nitroglycerin-induced calmodulin-dependent protein kinase II alpha in rat trigeminal nucleus caudalis.
Varga H, Pardutz A, Vamos E, Bohar Z, Bago F, Tajti J, Bari F, Vecsei L
Neurosci Lett. 2009
PubMed ID: 19121366
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Activity-dependent modulation of limbic dopamine D3 receptors by CaMKII.
Liu XY, Mao LM, Zhang GC, Papasian CJ, Fibuch EE, Lan HX, Zhou HF, Xu M, Wang JQ
Neuron. 2009
PubMed ID: 19217379
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Heterosynaptic molecular dynamics: locally induced propagating synaptic accumulation of CaM kinase II.
Rose J, Jin SX, Craig AM
Neuron. 2009
PubMed ID: 19217373
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Tensile strain-induced Ets-2 phosphorylation by CaMKII and the homeostasis of cranial sutures.
Yu JC, Chen JR, Lin CH, Zhang G, Lam PS, Wenger KH, Mozaffari FB, Huang ST, Borke JL
Plast Reconstr Surg. 2009
PubMed ID: 19182667
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Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB
Eur J Hum Genet. 2009
PubMed ID: 19156168
-
Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.
Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS, Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T, Scott HS
Genome Biol. 2009
PubMed ID: 19799774
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Neural activity changes underlying the working memory deficit in alpha-CaMKII heterozygous knockout mice.
Matsuo N, Yamasaki N, Ohira K, Takao K, Toyama K, Eguchi M, Yamaguchi S, Miyakawa T
Front Behav Neurosci. 2009
PubMed ID: 19750198
-
Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.
Fernández E, Collins MO, Uren RT, Kopanitsa MV, Komiyama NH, Croning MD, Zografos L, Armstrong JD, Choudhary JS, Grant SG
Mol Syst Biol. 2009
PubMed ID: 19455133
-
Activation of cytosolic phospholipase A2 in dorsal root ganglion neurons by Ca2+/calmodulin-dependent protein kinase II after peripheral nerve injury.
Hasegawa S, Kohro Y, Tsuda M, Inoue K
Mol Pain. 2009
PubMed ID: 19409102
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Transgenic up-regulation of alpha-CaMKII in forebrain leads to increased anxiety-like behaviors and aggression.
Hasegawa S, Furuichi T, Yoshida T, Endoh K, Kato K, Sado M, Maeda R, Kitamoto A, Miyao T, Suzuki R, Homma S, Masushige S, Kajii Y, Kida S
Mol Brain. 2009
PubMed ID: 19257910
-
Ca(2+) permeable AMPA receptor induced long-term potentiation requires PI3/MAP kinases but not Ca/CaM-dependent kinase II.
Asrar S, Zhou Z, Ren W, Jia Z
PLoS One. 2009
PubMed ID: 19190753
-
CAMKII activation is not required for maintenance of learning-induced enhancement of neuronal excitability.
Liraz O, Rosenblum K, Barkai E
PLoS ONE. 2009
PubMed ID: 19172997
-
CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages.
Liu X, Yao M, Li N, Wang C, Zheng Y, Cao X
Blood. 2008
PubMed ID: 18818394
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CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling.
Wheeler DG, Barrett CF, Groth RD, Safa P, Tsien RW
J Cell Biol. 2008
PubMed ID: 19047462
-
Activity-dependent regulation of the dopamine transporter is mediated by Ca(2+)/calmodulin-dependent protein kinase signaling.
Padmanabhan S, Lambert NA, Prasad BM
Eur J Neurosci. 2008
PubMed ID: 19046383
-
Nonclassical mechanisms of progesterone action in the brain: II. Role of calmodulin-dependent protein kinase II in progesterone-mediated signaling in the hypothalamus of female rats.
Balasubramanian B, Portillo W, Reyna A, Chen JZ, Moore AN, Dash PK, Mani SK
Endocrinology. 2008
PubMed ID: 18617607
-
Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions.
McFarland MA, Ellis CE, Markey SP, Nussbaum RL
Mol Cell Proteomics. 2008
PubMed ID: 18614564
-
A two-state model for Ca2+/CaM-dependent protein kinase II (alphaCaMKII) in response to persistent Ca2+ stimulation in hippocampal neurons.
Grant PA, Best SL, Sanmugalingam N, Alessio R, Jama AM, Török K
Cell Calcium. 2008
PubMed ID: 18436302
-
Domain structure responsible for the different properties between alpha and beta Ca2+/calmodulin-dependent protein kinase II analyzed by their chimera enzymes.
Deguchi A, Hata M, Uhara T, Yamauchi T
Brain Res. 2008
PubMed ID: 18703025
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Inducible and selective erasure of memories in the mouse brain via chemical-genetic manipulation.
Cao X, Wang H, Mei B, An S, Yin L, Wang LP, Tsien JZ
Neuron. 2008
PubMed ID: 18957226
-
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
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Chronic, but not acute morphine treatment, up-regulates alpha-Ca2+/calmodulin dependent protein kinase II gene expression in rat brain.
Chen Y, Jiang Y, Yue W, Zhou Y, Lu L, Ma L
Neurochem Res. 2008
PubMed ID: 18408996
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NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.
Bodrikov V, Sytnyk V, Leshchyns'ka I, den Hertog J, Schachner M
J Cell Biol. 2008
PubMed ID: 18809727
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Ca2+/calmodulin-dependent protein kinase II-dependent remodeling of Ca2+ current in pressure overload heart failure.
Wang Y, Tandan S, Cheng J, Yang C, Nguyen L, Sugianto J, Johnstone JL, Sun Y, Hill JA
J Biol Chem. 2008
PubMed ID: 18622016
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Optical induction of plasticity at single synapses reveals input-specific accumulation of alphaCaMKII.
Zhang YP, Holbro N, Oertner TG
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18697934
-
CaMK-II promotes focal adhesion turnover and cell motility by inducing tyrosine dephosphorylation of FAK and paxillin.
Easley CA, Brown CM, Horwitz AF, Tombes RM
Cell Motil Cytoskeleton. 2008
PubMed ID: 18613116
-
Ethanol inhibition of recombinant NMDA receptors is not altered by coexpression of CaMKII-alpha or CaMKII-beta.
Xu M, Chandler LJ, Woodward JJ
Alcohol. 2008
PubMed ID: 18562151
-
C9orf10 protein, a novel protein component of Puralpha-containing mRNA-protein particles (Puralpha-mRNPs): characterization of developmental and regional expressions in the mouse brain.
Kobayashi Y, Suzuki K, Kobayashi H, Ohashi S, Koike K, Macchi P, Kiebler M, Anzai K
J Histochem Cytochem. 2008
PubMed ID: 18413649
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Alpha-Ca2+/calmodulin-dependent protein kinase II contributes to the developmental programming of anxiety in serotonin receptor 1A knock-out mice.
Lo Iacono L, Gross C
J Neurosci. 2008
PubMed ID: 18550767
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Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II.
Song T, Hatano N, Kambe T, Miyamoto Y, Ihara H, Yamamoto H, Sugimoto K, Kume K, Yamaguchi F, Tokuda M, Watanabe Y
Biochem J. 2008
PubMed ID: 18271754
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Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells.
Mizutani A, Kuroda Y, Futatsugi A, Furuichi T, Mikoshiba K
J Neurosci. 2008
PubMed ID: 18480293
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Multiplexed dendritic targeting of alpha calcium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associated protein RNAs by the A2 pathway.
Gao Y, Tatavarty V, Korza G, Levin MK, Carson JH
Mol Biol Cell. 2008
PubMed ID: 18305102
-
GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells.
Pang J, Yan C, Natarajan K, Cavet ME, Massett MP, Yin G, Berk BC
Arterioscler Thromb Vasc Biol. 2008
PubMed ID: 18292392
-
Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle c
Lee CW, Lin CC, Luo SF, Lee HC, Lee IT, Aird WC, Hwang TL, Yang CM
Mol Pharmacol. 2008
PubMed ID: 18227124
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A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization.
Wang C, Li N, Liu X, Zheng Y, Cao X
J Biol Chem. 2008
PubMed ID: 18305109
-
Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.
Harwood BN, Cross SK, Radford EE, Haac BE, De Vries WN
Dev Dyn. 2008
PubMed ID: 18351675
-
Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation.
Correia SS, Bassani S, Brown TC, Lisé MF, Backos DS, El-Husseini A, Passafaro M, Esteban JA
Nat Neurosci. 2008
PubMed ID: 18311135
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GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
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Kinase-dependent adhesion to fibronectin: regulation by calreticulin.
Papp S, Szabo E, Kim H, McCulloch CA, Opas M
Exp Cell Res. 2008
PubMed ID: 18255058
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Reversal of chronic inflammatory pain by acute inhibition of Ca2+/calmodulin-dependent protein kinase II.
Luo F, Yang C, Chen Y, Shukla P, Tang L, Wang LX, Wang ZJ
J Pharmacol Exp Ther. 2008
PubMed ID: 18178903
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Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure.
Bossuyt J, Helmstadter K, Wu X, Clements-Jewery H, Haworth RS, Avkiran M, Martin JL, Pogwizd SM, Bers DM
Circ Res. 2008
PubMed ID: 18218981
-
CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking.
Anderson SM, Famous KR, Sadri-Vakili G, Kumaresan V, Schmidt HD, Bass CE, Terwilliger EF, Cha JH, Pierce RC
Nat Neurosci. 2008
PubMed ID: 18278040
-
Decreased locomotor activity in mice expressing tTA under control of the CaMKII alpha promoter.
McKinney BC, Schneider JS, Schafer GL, Lowing JL, Mohan S, Zhao MX, Heng MY, Albin RL, Seasholtz AF, Akil H, Murphy GG
Genes Brain Behav. 2008
PubMed ID: 17640289
-
Identification of the RA response element and transcriptional silencer in human alphaCaMKII promoter.
Wang L, Bai J, Hu Y
Mol Biol Rep. 2008
PubMed ID: 17221287
-
Calmodulin kinase II inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein.
Khoo MS, Grueter CE, Eren M, Yang J, Zhang R, Bass MA, Lwin ST, Mendes LA, Vaughan DE, Colbran RJ, Anderson ME
J Mol Cell Cardiol. 2008
PubMed ID: 18048055
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Calcium/calmodulin-dependent kinase II mediates NO-elicited PKG activation to participate in spinal reflex potentiation in anesthetized rats.
Chen GD, Peng ML, Wang PY, Lee SD, Chang HM, Pan SF, Chen MJ, Tung KC, Lai CY, Lin TB
Am J Physiol Regul Integr Comp Physiol. 2008
PubMed ID: 18046020
-
Phospholamban knockout increases CaM kinase II activity and intracellular Ca2+ wave activity and alters contractile responses of murine gastric antrum.
Kim M, Hennig GW, Smith TK, Perrino BA
Am J Physiol Cell Physiol. 2008
PubMed ID: 18045856
-
Dynamics underlying synaptic gain between pairs of cortical pyramidal neurons.
Pratt KG, Taft CE, Burbea M, Turrigiano GG
Dev Neurobiol. 2008
PubMed ID: 17948240
-
Epinephrine inhibits analgesic tolerance to intrathecal administrated morphine and increases the expression of calcium-calmodulin-dependent protein kinase IIalpha.
Satarian L, Javan M, Fathollahi Y
Neurosci Lett. 2008
PubMed ID: 18053645
-
alpha-Isoform of calcium-calmodulin-dependent protein kinase II and postsynaptic density protein 95 differentially regulate synaptic expression of NR2A- and NR2B-containing N-methyl-d-aspartate receptors in hippocampus.
Park CS, Elgersma Y, Grant SG, Morrison JH
Neuroscience. 2008
PubMed ID: 18082335
-
Autophosphorylation of alphaCaMKII is differentially involved in new learning and unlearning mechanisms of memory extinction.
Kimura R, Silva AJ, Ohno M
Learn Mem. 2008
PubMed ID: 18984565
-
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.
Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, Takao K, Tanda K, Ohira K, Toyama K, Kanzaki K, Fukunaga K, Sudo Y, Ichinose H, Ikeda M, Iwata N, Ozaki N, Suzuki H, Higuchi M, Suhara T, Yuasa S, Miyakawa T
Mol Brain. 2008
PubMed ID: 18803808
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Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling.
Faulkner RL, Low LK, Liu XB, Coble J, Jones EG, Cheng HJ
Neural Dev. 2008
PubMed ID: 18727829
-
A high through-put reverse genetic screen identifies two genes involved in remote memory in mice.
Matynia A, Anagnostaras SG, Wiltgen BJ, Lacuesta M, Fanselow MS, Silva AJ
PLoS ONE. 2008
PubMed ID: 18464936
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Disruption of KIF17-Mint1 interaction by CaMKII-dependent phosphorylation: a molecular model of kinesin-cargo release.
Guillaud L, Wong R, Hirokawa N
Nat Cell Biol. 2008
PubMed ID: 18066053
-
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
Ballif BA, Carey GR, Sunyaev SR, Gygi SP
J Proteome Res. 2008
PubMed ID: 18034455
-
Synaptic strength of individual spines correlates with bound Ca2+-calmodulin-dependent kinase II.
Asrican B, Lisman J, Otmakhov N
J Neurosci. 2007
PubMed ID: 18094239
-
Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning.
Zhou Y, Takahashi E, Li W, Halt A, Wiltgen B, Ehninger D, Li GD, Hell JW, Kennedy MB, Silva AJ
J Neurosci. 2007
PubMed ID: 18077696
-
Spatiotemporal dynamics of cortical sensorimotor integration in behaving mice.
Ferezou I, Haiss F, Gentet LJ, Aronoff R, Weber B, Petersen CC
Neuron. 2007
PubMed ID: 18054865
-
Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes.
Faul C, Dhume A, Schecter AD, Mundel P
Mol Cell Biol. 2007
PubMed ID: 17923693
-
CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses.
Zhang T, Kohlhaas M, Backs J, Mishra S, Phillips W, Dybkova N, Chang S, Ling H, Bers DM, Maier LS, Olson EN, Brown JH
J Biol Chem. 2007
PubMed ID: 17923476
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NMDA receptor-dependent long-term potentiation in mouse hippocampal interneurons shows a unique dependence on Ca(2+)/calmodulin-dependent kinases.
Lamsa K, Irvine EE, Giese KP, Kullmann DM
J Physiol. 2007
PubMed ID: 17884930
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Inactivation of the gene for the nuclear receptor tailless in the brain preserving its function in the eye.
Belz T, Liu HK, Bock D, Takacs A, Vogt M, Wintermantel T, Brandwein C, Gass P, Greiner E, Schütz G
Eur J Neurosci. 2007
PubMed ID: 17953618
-
Amphetamine sensitization elevates CaMKIIbeta mRNA.
Greenstein R, Novak G, Seeman P
Synapse. 2007
PubMed ID: 17603807
-
Postsynaptic secretion of BDNF and NT-3 from hippocampal neurons depends on calcium calmodulin kinase II signaling and proceeds via delayed fusion pore opening.
Kolarow R, Brigadski T, Lessmann V
J Neurosci. 2007
PubMed ID: 17898207
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Calmodulin kinase II inhibition enhances ischemic preconditioning by augmenting ATP-sensitive K+ current.
Li J, Marionneau C, Koval O, Zingman L, Mohler PJ, Nerbonne JM, Anderson ME
Channels (Austin). 2007
PubMed ID: 18690039
-
Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban.
Kemi OJ, Ellingsen O, Ceci M, Grimaldi S, Smith GL, Condorelli G, Wisløff U
J Mol Cell Cardiol. 2007
PubMed ID: 17689560
-
Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses.
Hojjati MR, van Woerden GM, Tyler WJ, Giese KP, Silva AJ, Pozzo-Miller L, Elgersma Y
Nat Neurosci. 2007
PubMed ID: 17660813
-
alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression.
Yuan K, Chung LW, Siegal GP, Zayzafoon M
Lab Invest. 2007
PubMed ID: 17632540
-
Effect of endurance exercise training on Ca2+ calmodulin-dependent protein kinase II expression and signalling in skeletal muscle of humans.
Rose AJ, Frøsig C, Kiens B, Wojtaszewski JF, Richter EA
J Physiol. 2007
PubMed ID: 17627985
-
Acetylcholine increases Ca2+ influx by activation of CaMKII in mouse oocytes.
Kang D, Hur CG, Park JY, Han J, Hong SG
Biochem Biophys Res Commun. 2007
PubMed ID: 17603011
-
Extracellular calcium induces activation of Ca(2+)/calmodulin-dependent protein kinase II and mediates spontaneous activation in rat oocytes.
Yoo JG, Smith LC
Biochem Biophys Res Commun. 2007
PubMed ID: 17570344
-
CaMKIIalphaB mediates a survival response in retinal ganglion cells subjected to a glutamate stimulus.
Fan W, Li X, Cooper NG
Invest Ophthalmol Vis Sci. 2007
PubMed ID: 17652761
-
Quantitative proteomics and protein network analysis of hippocampal synapses of CaMKIIalpha mutant mice.
Li KW, Miller S, Klychnikov O, Loos M, Stahl-Zeng J, Spijker S, Mayford M, Smit AB
J Proteome Res. 2007
PubMed ID: 17625814
-
CaMKII can participate in but is not sufficient for the establishment of the membrane block to polyspermy in mouse eggs.
Gardner AJ, Knott JG, Jones KT, Evans JP
J Cell Physiol. 2007
PubMed ID: 17455234
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Experience-dependent increase in CA1 place cell spatial information, but not spatial reproducibility, is dependent on the autophosphorylation of the alpha-isoform of the calcium/calmodulin-dependent protein kinase II.
Cacucci F, Wills TJ, Lever C, Giese KP, O'Keefe J
J Neurosci. 2007
PubMed ID: 17634379
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Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53.
Duan S, Yao Z, Hou D, Wu Z, Zhu WG, Wu M
EMBO J. 2007
PubMed ID: 17568776
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Identification of the sites for CaMK-II-dependent phosphorylation of GABA(A) receptors.
Houston CM, Lee HH, Hosie AM, Moss SJ, Smart TG
J Biol Chem. 2007
PubMed ID: 17442679
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Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII.
Liu S, Fa M, Ninan I, Trinchese F, Dauer W, Arancio O
Eur J Neurosci. 2007
PubMed ID: 17610578
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Calcium-calmodulin kinase II is the common factor in calcium-dependent cardiac expression and secretion of A- and B-type natriuretic peptides.
Ronkainen JJ, Vuolteenaho O, Tavi P
Endocrinology. 2007
PubMed ID: 17332063
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Reversal of synaptic memory by Ca2+/calmodulin-dependent protein kinase II inhibitor.
Sanhueza M, McIntyre CC, Lisman JE
J Neurosci. 2007
PubMed ID: 17494705
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The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure.
Okamoto K, Narayanan R, Lee SH, Murata K, Hayashi Y
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17404223
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Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells.
Liu Y, Templeton DM
FEBS Lett. 2007
PubMed ID: 17367784
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The influence of Pavlovian cues on instrumental performance is mediated by CaMKII activity in the striatum.
Wiltgen BJ, Law M, Ostlund S, Mayford M, Balleine BW
Eur J Neurosci. 2007
PubMed ID: 17445244
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Reduced contractile response to alpha1-adrenergic stimulation in atria from mice with chronic cardiac calmodulin kinase II inhibition.
Grimm M, El-Armouche A, Zhang R, Anderson ME, Eschenhagen T
J Mol Cell Cardiol. 2007
PubMed ID: 17292391
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Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus.
Kee N, Teixeira CM, Wang AH, Frankland PW
Nat Neurosci. 2007
PubMed ID: 17277773
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Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation.
van Woerden GM, Harris KD, Hojjati MR, Gustin RM, Qiu S, de Avila Freire R, Jiang YH, Elgersma Y, Weeber EJ
Nat Neurosci. 2007
PubMed ID: 17259980
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Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II.
Ishiguro K, Ando T, Goto H, Xavier R
Mol Immunol. 2007
PubMed ID: 17052756
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Changes in Ca(2+)/calmodulin-dependent protein kinase II activity and its relation to performance in passive avoidance response and long-term potentiation formation in mice prenatally exposed to diethylstilbestrol.
Kaitsuka T, Fukunaga K, Soeda F, Shirasaki T, Miyamoto E, Takahama K
Neuroscience. 2007
PubMed ID: 17184923
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Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM
Mol Cell Proteomics. 2007
PubMed ID: 17114649
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Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
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Oestrogen-modulated increase of calmodulin-dependent protein kinase II (CamKII) in rat spinal trigeminal nucleus after systemic nitroglycerin.
Pardutz A, Hoyk Z, Varga H, Vecsei L, Schoenen J
Cephalalgia. 2007
PubMed ID: 17212683
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Enriching the environment of alphaCaMKIIT286A mutant mice reveals that LTD occurs in memory processing but must be subsequently reversed by LTP.
Parsley SL, Pilgram SM, Soto F, Giese KP, Edwards FA
Learn Mem. 2007
PubMed ID: 17202430
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CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation.
Picht E, DeSantiago J, Huke S, Kaetzel MA, Dedman JR, Bers DM
J Mol Cell Cardiol. 2007
PubMed ID: 17052727
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CaMKII translocation requires local NMDA receptor-mediated Ca2+ signaling.
Thalhammer A, Rudhard Y, Tigaret CM, Volynski KE, Rusakov DA, Schoepfer R
EMBO J. 2006
PubMed ID: 17124502
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Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivo.
Yang Y, Zhu WZ, Joiner ML, Zhang R, Oddis CV, Hou Y, Yang J, Price EE, Gleaves L, Eren M, Ni G, Vaughan DE, Xiao RP, Anderson ME
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16861697
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Differential modulation of Kv4.2 and Kv4.3 channels by calmodulin-dependent protein kinase II in rat cardiac myocytes.
Colinas O, Gallego M, Setién R, López-López JR, Pérez-García MT, Casis O
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16648177
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alphaCaMKII Is essential for cerebellar LTD and motor learning.
Hansel C, de Jeu M, Belmeguenai A, Houtman SH, Buitendijk GH, Andreev D, De Zeeuw CI, Elgersma Y
Neuron. 2006
PubMed ID: 16982427
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Involvement of phosphorylated Ca2+/calmodulin-dependent protein kinase II and phosphorylated extracellular signal-regulated protein in the mouse formalin pain model.
Choi SS, Seo YJ, Shim EJ, Kwon MS, Lee JY, Ham YO, Suh HW
Brain Res. 2006
PubMed ID: 16863646
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Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model.
Sasaki T, Han F, Shioda N, Moriguchi S, Kasahara J, Ishiguro K, Fukunaga K
Brain Res. 2006
PubMed ID: 16843447
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L-type Ca2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKII.
Grueter CE, Abiria SA, Dzhura I, Wu Y, Ham AJ, Mohler PJ, Anderson ME, Colbran RJ
Mol Cell. 2006
PubMed ID: 16949361
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Aberrant dendritic branching and sensory inputs in the superficial dorsal horn of mice lacking CaMKIIalpha autophosphorylation.
Pattinson D, Baccei M, Karadottir R, Torsney C, Moss A, McCutcheon J, Giese KP, Fitzgerald M
Mol Cell Neurosci. 2006
PubMed ID: 16875841
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Mechanisms for association of Ca2+/calmodulin-dependent protein kinase II with lipid rafts.
Du F, Saitoh F, Tian QB, Miyazawa S, Endo S, Suzuki T
Biochem Biophys Res Commun. 2006
PubMed ID: 16872923
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Calmodulin kinase II is involved in voltage-dependent facilitation of the L-type Cav1.2 calcium channel: Identification of the phosphorylation sites.
Lee TS, Karl R, Moosmang S, Lenhardt P, Klugbauer N, Hofmann F, Kleppisch T, Welling A
J Biol Chem. 2006
PubMed ID: 16820363
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A beta1-adrenergic receptor CaM kinase II-dependent pathway mediates cardiac myocyte fetal gene induction.
Sucharov CC, Mariner PD, Nunley KR, Long C, Leinwand L, Bristow MR
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16501029
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Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes.
Guo T, Zhang T, Mestril R, Bers DM
Circ Res. 2006
PubMed ID: 16840718
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Calmodulin-dependent protein kinase II triggers mouse egg activation and embryo development in the absence of Ca2+ oscillations.
Knott JG, Gardner AJ, Madgwick S, Jones KT, Williams CJ, Schultz RM
Dev Biol. 2006
PubMed ID: 16824507
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Autophosphorylation of alphaCaMKII is not a general requirement for NMDA receptor-dependent LTP in the adult mouse.
Cooke SF, Wu J, Plattner F, Errington M, Rowan M, Peters M, Hirano A, Bradshaw KD, Anwyl R, Bliss TV, Giese KP
J Physiol. 2006
PubMed ID: 16728448
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Calmodulin kinase II accelerates L-type Ca2+ current recovery from inactivation and compensates for the direct inhibitory effect of [Ca2+]i in rat ventricular myocytes.
Guo J, Duff HJ
J Physiol. 2006
PubMed ID: 16627565
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Phosphorylation of microtubule-associated protein STOP by calmodulin kinase II.
Baratier J, Peris L, Brocard J, Gory-Fauré S, Dufour F, Bosc C, Fourest-Lieuvin A, Blanchoin L, Salin P, Job D, Andrieux A
J Biol Chem. 2006
PubMed ID: 16651267
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A mechanism for the inactivation of Ca2+/calmodulin-dependent protein kinase II during prolonged seizure activity and its consequence after the recovery from seizure activity in rats in vivo.
Yamagata Y, Imoto K, Obata K
Neuroscience. 2006
PubMed ID: 16632208
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Regulation of protein phosphatase 2A-mediated recruitment of IQGAP1 to beta1 integrin by EGF through activation of Ca2+/calmodulin-dependent protein kinase II.
Takahashi K, Suzuki K
J Cell Physiol. 2006
PubMed ID: 16557530
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NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.
Nakazawa T, Komai S, Watabe AM, Kiyama Y, Fukaya M, Arima-Yoshida F, Horai R, Sudo K, Ebine K, Delawary M, Goto J, Umemori H, Tezuka T, Iwakura Y, Watanabe M, Yamamoto T, Manabe T
EMBO J. 2006
PubMed ID: 16710293
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Changes in the distribution of calcium calmodulin-dependent protein kinase II at the presynaptic bouton after depolarization.
Tao-Cheng JH, Dosemeci A, Winters CA, Reese TS
Brain Cell Biol. 2006
PubMed ID: 17957478
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Long-term potentiation is mediated by multiple kinase cascades involving CaMKII or either PKA or p42/44 MAPK in the adult rat dentate gyrus in vitro.
Wu J, Rowan MJ, Anwyl R
J Neurophysiol. 2006
PubMed ID: 16709720
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Laminin activates CaMK-II to stabilize nascent embryonic axons.
Easley CA, Faison MO, Kirsch TL, Lee JA, Seward ME, Tombes RM
Brain Res. 2006
PubMed ID: 16690036
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Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells.
Bourguignon LY, Gilad E, Brightman A, Diedrich F, Singleton P
J Biol Chem. 2006
PubMed ID: 16565089
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Nuclear targeting of the CaMKII anchoring protein alphaKAP is regulated by alternative splicing and protein kinases.
O'Leary H, Sui X, Lin PJ, Volpe P, Bayer KU
Brain Res. 2006
PubMed ID: 16616897
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CaMKII inactivation by extracellular Ca(2+) depletion in dorsal root ganglion neurons.
Cohen JE, Fields RD
Cell Calcium. 2006
PubMed ID: 16519936
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Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability.
Ohno M, Sametsky EA, Silva AJ, Disterhoft JF
Eur J Neurosci. 2006
PubMed ID: 16630070
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BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
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Decreased calcium/calmodulin-dependent protein kinase II and protein kinase C activities mediate impairment of hippocampal long-term potentiation in the olfactory bulbectomized mice.
Moriguchi S, Han F, Nakagawasai O, Tadano T, Fukunaga K
J Neurochem. 2006
PubMed ID: 16515554
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Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II.
Rosenberg OS, Deindl S, Comolli LR, Hoelz A, Downing KH, Nairn AC, Kuriyan J
FEBS J. 2006
PubMed ID: 16441656
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Differential modification of phosducin protein in degenerating rd1 retina is associated with constitutively active Ca2+/calmodulin kinase II in rod outer segments.
Hauck SM, Ekström PA, Ahuja-Jensen P, Suppmann S, Paquet-Durand F, van Veen T, Ueffing M
Mol Cell Proteomics. 2006
PubMed ID: 16253986
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Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B.
Bayer KU, LeBel E, McDonald GL, O'Leary H, Schulman H, De Koninck P
J Neurosci. 2006
PubMed ID: 16436603
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Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia.
Wei F, Wang GD, Zhang C, Shokat KM, Wang H, Tsien JZ, Liauw J, Zhuo M
Mol Pain. 2006
PubMed ID: 16776832
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Identification of the isoforms of Ca2+/calmodulin-dependent protein kinase II and expression of brain-derived neurotrophic factor mRNAs in the substantia nigra.
Kamata A, Takeuchi Y, Fukunaga K
J Neurochem. 2006
PubMed ID: 16277604
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Increased expression of calcium/calmodulin-dependent protein kinase IIbeta in frontal cortex in schizophrenia and depression.
Novak G, Seeman P, Tallerico T
Synapse. 2006
PubMed ID: 16247765
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Synaptic activity and F-actin coordinately regulate CaMKIIalpha localization to dendritic postsynaptic sites in developing hippocampal slices.
Ahmed R, Zha XM, Green SH, Dailey ME
Mol Cell Neurosci. 2006
PubMed ID: 16214364
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Pharmacological interactions between calcium/calmodulin-dependent kinase II alpha and TRPV1 receptors in rat trigeminal sensory neurons.
Price TJ, Jeske NA, Flores CM, Hargreaves KM
Neurosci Lett. 2005
PubMed ID: 16095822
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Radixin stimulates Rac1 and Ca2+/calmodulin-dependent kinase, CaMKII: cross-talk with Galpha13 signaling.
Liu G, Voyno-Yasenetskaya TA
J Biol Chem. 2005
PubMed ID: 16186118
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Differential modulation of Ca2+/calmodulin-dependent protein kinase II activity by regulated interactions with N-methyl-D-aspartate receptor NR2B subunits and alpha-actinin.
Robison AJ, Bartlett RK, Bass MA, Colbran RJ
J Biol Chem. 2005
PubMed ID: 16172120
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Ocular dominance plasticity is stably maintained in the absence of alpha calcium calmodulin kinase II (alphaCaMKII) autophosphorylation.
Taha SA, Stryker MP
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16260732
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IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism.
Netea MG, Azam T, Ferwerda G, Girardin SE, Walsh M, Park JS, Abraham E, Kim JM, Yoon DY, Dinarello CA, Kim SH
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16260731
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Neuronal cell type-specific promoter of the alpha CaM kinase II gene is activated by Zic2, a Zic family zinc finger protein.
Sakurada T, Mima K, Kurisaki A, Sugino H, Yamauchi T
Neurosci Res. 2005
PubMed ID: 16157407
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Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus.
Hao ZB, Pei DS, Guan QH, Zhang GY
Brain Res Mol Brain Res. 2005
PubMed ID: 16126302
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Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2.
Robison AJ, Bass MA, Jiao Y, MacMillan LB, Carmody LC, Bartlett RK, Colbran RJ
J Biol Chem. 2005
PubMed ID: 16120608
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Activation of nuclear factor {kappa}B by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves G{alpha}14 and multiple signaling components: a mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src.
Liu AM, Wong YH
J Biol Chem. 2005
PubMed ID: 16115892
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Analysis of pThr286-CaMKII and CaMKII immunohistochemistry in the hippocampus of patients with temporal lobe epilepsy.
Lie AA, Sommersberg B, Elger CE
Epilepsy Res. 2005
PubMed ID: 16207525
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Transgenic mice overexpressing nNOS in the adult nervous system.
Packer MA, Hemish J, Mignone JL, John S, Pugach I, Enikolopov G
Cell Mol Biol (Noisy-le-grand). 2005
PubMed ID: 16191394
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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Calmodulin-dependent protein kinase II, and not protein kinase C, is sufficient for triggering cell-cycle resumption in mammalian eggs.
Madgwick S, Levasseur M, Jones KT
J Cell Sci. 2005
PubMed ID: 16091425
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Behavioral testing upregulates pCaMKII, BDNF, PSD-95 and egr-1 in hippocampus of FVB/N mice.
Pollak DD, Herkner K, Hoeger H, Lubec G
Behav Brain Res. 2005
PubMed ID: 15927279
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Hippocampal synaptic metaplasticity requires inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II.
Zhang L, Kirschstein T, Sommersberg B, Merkens M, Manahan-Vaughan D, Elgersma Y, Beck H
J Neurosci. 2005
PubMed ID: 16107656
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Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region.
Pufall MA, Lee GM, Nelson ML, Kang HS, Velyvis A, Kay LE, McIntosh LP, Graves BJ
Science. 2005
PubMed ID: 15994560
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alpha1-adrenoceptor stimulation potentiates L-type Ca2+ current through Ca2+/calmodulin-dependent PK II (CaMKII) activation in rat ventricular myocytes.
O-Uchi J, Komukai K, Kusakari Y, Obata T, Hongo K, Sasaki H, Kurihara S
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15964981
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CaMKIIalpha enhances the desensitization of NR2B-containing NMDA receptors by an autophosphorylation-dependent mechanism.
Sessoms-Sikes S, Honse Y, Lovinger DM, Colbran RJ
Mol Cell Neurosci. 2005
PubMed ID: 15866054
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Calmodulin kinase II inhibition protects against structural heart disease.
Zhang R, Khoo MS, Wu Y, Yang Y, Grueter CE, Ni G, Price EE, Thiel W, Guatimosim S, Song LS, Madu EC, Shah AN, Vishnivetskaya TA, Atkinson JB, Gurevich VV, Salama G, Lederer WJ, Colbran RJ, Anderson ME
Nat Med. 2005
PubMed ID: 15793582
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AlphaCaMKII autophosphorylation contributes to rapid learning but is not necessary for memory.
Irvine EE, Vernon J, Giese KP
Nat Neurosci. 2005
PubMed ID: 15778710
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CaMKIIgamma-mediated inactivation of the Kin I kinesin MCAK is essential for bipolar spindle formation.
Holmfeldt P, Zhang X, Stenmark S, Walczak CE, Gullberg M
EMBO J. 2005
PubMed ID: 15775983
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Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress.
Gardner OS, Shiau CW, Chen CS, Graves LM
J Biol Chem. 2005
PubMed ID: 15649892
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Calmodulin and calmodulin-dependent kinase IIalpha regulate osteoblast differentiation by controlling c-fos expression.
Zayzafoon M, Fulzele K, McDonald JM
J Biol Chem. 2005
PubMed ID: 15590632
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Proteomic analysis of in vivo phosphorylated synaptic proteins.
Collins MO, Yu L, Coba MP, Husi H, Campuzano I, Blackstock WP, Choudhary JS, Grant SG
J Biol Chem. 2005
PubMed ID: 15572359
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BAALC 1-6-8 protein is targeted to postsynaptic lipid rafts by its N-terminal myristoylation and palmitoylation, and interacts with alpha, but not beta, subunit of Ca/calmodulin-dependent protein kinase II.
Wang X, Tian QB, Okano A, Sakagami H, Moon IS, Kondo H, Endo S, Suzuki T
J Neurochem. 2005
PubMed ID: 15659234
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Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol.
Vosseller K, Hansen KC, Chalkley RJ, Trinidad JC, Wells L, Hart GW, Burlingame AL
Proteomics. 2005
PubMed ID: 15648052
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Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs.
Tomita S, Stein V, Stocker TJ, Nicoll RA, Bredt DS
Neuron. 2005
PubMed ID: 15664178
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The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology.
Wang YJ, Chen GH, Hu XY, Lu YP, Zhou JN, Liu RY
Brain Res. 2005
PubMed ID: 15621017
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Role of phosphorylated CaMKII and calcineurin in the differential effect of hypothyroidism on LTP of CA1 and dentate gyrus.
Gerges NZ, Alzoubi KH, Alkadhi KA
Hippocampus. 2005
PubMed ID: 15714506
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A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins.
Suzuki T, Li W, Zhang JP, Tian QB, Sakagami H, Usuda N, Usada N, Kondo H, Fujii T, Endo S
Eur J Neurosci. 2005
PubMed ID: 15673434
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Ca(2+)/calmodulin-dependent protein kinase II inhibition by heparin in mesangial cells.
Xiao W, Liu Y, Templeton DM
Am J Physiol Renal Physiol. 2005
PubMed ID: 15383398
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A neurogenomics approach to gene expression analysis in the developing brain.
Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T
Brain Res Mol Brain Res. 2004
PubMed ID: 15582152
-
Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway.
Ju BG, Solum D, Song EJ, Lee KJ, Rose DW, Glass CK, Rosenfeld MG
Cell. 2004
PubMed ID: 15607978
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Strong calcium entry activates mitochondrial superoxide generation, upregulating kinase signaling in hippocampal neurons.
Hongpaisan J, Winters CA, Andrews SB
J Neurosci. 2004
PubMed ID: 15574738
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Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway.
Wang W, Zhu W, Wang S, Yang D, Crow MT, Xiao RP, Cheng H
Circ Res. 2004
PubMed ID: 15375008
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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The DNA sequence and comparative analysis of human chromosome 5.
Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM
Nature. 2004
PubMed ID: 15372022
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SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation.
Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE
Neuron. 2004
PubMed ID: 15312654
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Identification of novel phosphorylation sites on postsynaptic density proteins.
Jaffe H, Vinade L, Dosemeci A
Biochem Biophys Res Commun. 2004
PubMed ID: 15358237
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Ca2+/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors.
Xu GY, Huang LY
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15292517
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Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts.
Harvey BP, Banga SS, Ozer HL
J Biol Chem. 2004
PubMed ID: 15140879
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The involvement of the anterior cingulate cortex in remote contextual fear memory.
Frankland PW, Bontempi B, Talton LE, Kaczmarek L, Silva AJ
Science. 2004
PubMed ID: 15131309
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Ventricular arrhythmias, increased cardiac calmodulin kinase II expression, and altered repolarization kinetics in ANP receptor deficient mice.
Kirchhof P, Fabritz L, Kilić A, Begrow F, Breithardt G, Kuhn M
J Mol Cell Cardiol. 2004
PubMed ID: 15135664
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Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II.
Oh JS, Manzerra P, Kennedy MB
J Biol Chem. 2004
PubMed ID: 14970204
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PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus.
Song B, Yan XB, Zhang GY
Brain Res. 2004
PubMed ID: 15044063
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Ca2+/calmodulin-dependent protein kinase II in the rat cranial sensory ganglia.
Ichikawa H, Gouty S, Regalia J, Helke CJ, Sugimoto T
Brain Res. 2004
PubMed ID: 15044062
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Defective neocortical development in Fyn-tyrosine-kinase-deficient mice.
Yuasa S, Hattori K, Yagi T
Neuroreport. 2004
PubMed ID: 15073522
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Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II.
Gaertner TR, Kolodziej SJ, Wang D, Kobayashi R, Koomen JM, Stoops JK, Waxham MN
J Biol Chem. 2004
PubMed ID: 14722083
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Bioinformatics and cellular signaling.
Papin J, Subramaniam S
Curr Opin Biotechnol. 2004
PubMed ID: 15102471
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The contribution of autophosphorylated alpha-calcium-calmodulin kinase II to injury-induced persistent pain.
Zeitz KP, Giese KP, Silva AJ, Basbaum AI
Neuroscience. 2004
PubMed ID: 15464294
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Phospholamban is required for CaMKII-dependent recovery of Ca transients and SR Ca reuptake during acidosis in cardiac myocytes.
DeSantiago J, Maier LS, Bers DM
J Mol Cell Cardiol. 2004
PubMed ID: 14734049
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Suppressing calcium/calmodulin-dependent protein kinase II activity in the ventral tegmental area enhances the acute behavioural response to cocaine but attenuates the initiation of cocaine-induced behavioural sensitization in rats.
Licata SC, Schmidt HD, Pierce RC
Eur J Neurosci. 2004
PubMed ID: 14725635
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Protein kinase C-gamma and calcium/calmodulin-dependent protein kinase II-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion.
Matsumoto S, Shamloo M, Matsumoto E, Isshiki A, Wieloch T
J Cereb Blood Flow Metab. 2004
PubMed ID: 14688616
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Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.
Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, Santos R, Schadt EE, Stoughton R, Shoemaker DD
Science. 2003
PubMed ID: 14684825
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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Calcium/calmodulin-dependent protein kinase II binds to Raf-1 and modulates integrin-stimulated ERK activation.
Illario M, Cavallo AL, Bayer KU, Di Matola T, Fenzi G, Rossi G, Vitale M
J Biol Chem. 2003
PubMed ID: 12954639
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The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.
Krapivinsky G, Krapivinsky L, Manasian Y, Ivanov A, Tyzio R, Pellegrino C, Ben-Ari Y, Clapham DE, Medina I
Neuron. 2003
PubMed ID: 14622581
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CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction.
Gardoni F, Mauceri D, Fiorentini C, Bellone C, Missale C, Cattabeni F, Di Luca M
J Biol Chem. 2003
PubMed ID: 12933808
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CyclinB1 expression is elevated and mitosis is delayed in HeLa cells expressing autonomous CaMKII.
Beauman SR, Campos B, Kaetzel MA, Dedman JR
Cell Signal. 2003
PubMed ID: 14499348
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Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival.
Linseman DA, Bartley CM, Le SS, Laessig TA, Bouchard RJ, Meintzer MK, Li M, Heidenreich KA
J Biol Chem. 2003
PubMed ID: 12896970
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Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats.
Song B, Meng F, Yan X, Guo J, Zhang G
Neurosci Lett. 2003
PubMed ID: 12951199
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Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.
Sun L, Bittner MA, Holz RW
J Biol Chem. 2003
PubMed ID: 12871946
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Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle.
Cairns BE, Svensson P, Wang K, Hupfeld S, Graven-Nielsen T, Sessle BJ, Berde CB, Arendt-Nielsen L
J Neurophysiol. 2003
PubMed ID: 12815021
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Calmodulin kinase modulates Ca2+ release in mouse skeletal muscle.
Tavi P, Allen DG, Niemelä P, Vuolteenaho O, Weckström M, Westerblad H
J Physiol. 2003
PubMed ID: 12824452
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Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII.
Fink CC, Bayer KU, Myers JW, Ferrell JE, Schulman H, Meyer T
Neuron. 2003
PubMed ID: 12873385
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Activity-dependent remodeling of presynaptic inputs by postsynaptic expression of activated CaMKII.
Pratt KG, Watt AJ, Griffith LC, Nelson SB, Turrigiano GG
Neuron. 2003
PubMed ID: 12873384
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Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle.
Afroze T, Yang LL, Wang C, Gros R, Kalair W, Hoque AN, Mungrue IN, Zhu Z, Husain M
Am J Physiol Cell Physiol. 2003
PubMed ID: 12660151
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Oscillatory CaMKII activity in mouse egg activation.
Markoulaki S, Matson S, Abbott AL, Ducibella T
Dev Biol. 2003
PubMed ID: 12798302
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Handling and environmental enrichment do not rescue learning and memory impairments in alphaCamKII(T286A) mutant mice.
Need AC, Giese KP
Genes Brain Behav. 2003
PubMed ID: 12931786
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Bursts of high-frequency stimulation trigger rapid delivery of pre-existing alpha-CaMKII mRNA to synapses: a mechanism in dendritic protein synthesis during long-term potentiation in adult awake rats.
Håvik B, Røkke H, Bårdsen K, Davanger S, Bramham CR
Eur J Neurosci. 2003
PubMed ID: 12823475
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Neocortical long-term potentiation and experience-dependent synaptic plasticity require alpha-calcium/calmodulin-dependent protein kinase II autophosphorylation.
Hardingham N, Glazewski S, Pakhotin P, Mizuno K, Chapman PF, Giese KP, Fox K
J Neurosci. 2003
PubMed ID: 12805283
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Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase.
Watanabe Y, Song T, Sugimoto K, Horii M, Araki N, Tokumitsu H, Tezuka T, Yamamoto T, Tokuda M
Biochem J. 2003
PubMed ID: 12630910
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Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II.
Hoelz A, Nairn AC, Kuriyan J
Mol Cell. 2003
PubMed ID: 12769848
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Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome.
Weeber EJ, Jiang YH, Elgersma Y, Varga AW, Carrasquillo Y, Brown SE, Christian JM, Mirnikjoo B, Silva A, Beaudet AL, Sweatt JD
J Neurosci. 2003
PubMed ID: 12684449
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Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain.
Wang H, Shimizu E, Tang YP, Cho M, Kyin M, Zuo W, Robinson DA, Alaimo PJ, Zhang C, Morimoto H, Zhuo M, Feng R, Shokat KM, Tsien JZ
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12646704
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Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse.
Hinds HL, Goussakov I, Nakazawa K, Tonegawa S, Bolshakov VY
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12629219
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RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling.
Okabe T, Nakamura T, Nishimura YN, Kohu K, Ohwada S, Morishita Y, Akiyama T
J Biol Chem. 2003
PubMed ID: 12531901
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Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.
Zhu WZ, Wang SQ, Chakir K, Yang D, Zhang T, Brown JH, Devic E, Kobilka BK, Cheng H, Xiao RP
J Clin Invest. 2003
PubMed ID: 12618516
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Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S, Nakajima D, Nagase T, Ohara O, Koga H
DNA Res. 2003
PubMed ID: 12693553
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Phosphorylation of 69-kDa choline acetyltransferase at threonine 456 in response to amyloid-beta peptide 1-42.
Dobransky T, Brewer D, Lajoie G, Rylett RJ
J Biol Chem. 2003
PubMed ID: 12486117
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Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo.
Colomer JM, Mao L, Rockman HA, Means AR
Mol Endocrinol. 2003
PubMed ID: 12554746
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CaM kinase IIdeltaC phosphorylation of 14-3-3beta in vascular smooth muscle cells: activation of class II HDAC repression.
Ellis JJ, Valencia TG, Zeng H, Roberts LD, Deaton RA, Grant SR
Mol Cell Biochem. 2003
PubMed ID: 12619878
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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Calcium regulation of GM-CSF by calmodulin-dependent kinase II phosphorylation of Ets1.
Liu H, Grundström T
Mol Biol Cell. 2002
PubMed ID: 12475968
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Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286.
Chin D, Means AR
Biochemistry. 2002
PubMed ID: 12437357
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Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha induced by cerebral ischemia immediately targets and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in hippocampus of rats.
Meng F, Zhang G
Neurosci Lett. 2002
PubMed ID: 12401560
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Disruption of dendritic translation of CaMKIIalpha impairs stabilization of synaptic plasticity and memory consolidation.
Miller S, Yasuda M, Coats JK, Jones Y, Martone ME, Mayford M
Neuron. 2002
PubMed ID: 12408852
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Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning.
Elgersma Y, Fedorov NB, Ikonen S, Choi ES, Elgersma M, Carvalho OM, Giese KP, Silva AJ
Neuron. 2002
PubMed ID: 12408851
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Autophosphorylation of alphaCaMKII is required for ocular dominance plasticity.
Taha S, Hanover JL, Silva AJ, Stryker MP
Neuron. 2002
PubMed ID: 12408850
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Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta.
Liu F, Iqbal K, Grundke-Iqbal I, Gong CX
FEBS Lett. 2002
PubMed ID: 12387894
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Developmentally regulated expression of CaMKII and iGluRs in the rat retina.
Xue J, Li G, Bharucha E, Cooper NG
Brain Res Dev Brain Res. 2002
PubMed ID: 12234658
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Estrogen induces a rapid increase of calcium-calmodulin-dependent protein kinase II activity in the hippocampus.
Sawai T, Bernier F, Fukushima T, Hashimoto T, Ogura H, Nishizawa Y
Brain Res. 2002
PubMed ID: 12231258
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The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner.
Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH
J Neurosci. 2002
PubMed ID: 12223541
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Persistent phosphorylation of synaptic proteins following middle cerebral artery occlusion.
Matsumoto S, Shamloo M, Isshiki A, Wieloch T
J Cereb Blood Flow Metab. 2002
PubMed ID: 12218416
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Phosphorylation of neuronal nitric oxide synthase at Ser847 by CaM-KII in the hippocampus of rat brain after transient forebrain ischemia.
Osuka K, Watanabe Y, Usuda N, Nakazawa A, Fukunaga K, Miyamoto E, Takayasu M, Tokuda M, Yoshida J
J Cereb Blood Flow Metab. 2002
PubMed ID: 12218415
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Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII.
Mayadevi M, Praseeda M, Kumar KS, Omkumar RV
Biochim Biophys Acta. 2002
PubMed ID: 12147342
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A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD
Science. 2002
PubMed ID: 12040188
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A pharmacogenetic inducible approach to the study of NMDA/alphaCaMKII signaling in synaptic plasticity.
Ohno M, Frankland PW, Silva AJ
Curr Biol. 2002
PubMed ID: 11967152
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Decreased prefrontal CaMKII alpha mRNA in bipolar illness.
Xing G, Russell S, Hough C, O'Grady J, Zhang L, Yang S, Zhang LX, Post R
Neuroreport. 2002
PubMed ID: 11930170
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[Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions]
Yamamoto H
Tanpakushitsu Kakusan Koso. 2002
PubMed ID: 11889801
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Beta(3)-mediated engulfment of apoptotic tumor cells by dendritic cells is dependent on CAMKII: inhibition by HIV-1 Tat.
Poggi A, Carosio R, Rubartelli A, Zocchi MR
J Leukoc Biol. 2002
PubMed ID: 11867691
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Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain.
Fallon L, Moreau F, Croft BG, Labib N, Gu WJ, Fon EA
J Biol Chem. 2002
PubMed ID: 11679592
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Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.
Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Gong CX
Neuroscience. 2002
PubMed ID: 12435421
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Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected].
Sheriff S, F Qureshy A, T Chance W, Kasckow JW, Balasubramaniam A
Peptides. 2002
PubMed ID: 11814622
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NK cell activation by dendritic cells is dependent on LFA-1-mediated induction of calcium-calmodulin kinase II: inhibition by HIV-1 Tat C-terminal domain.
Poggi A, Carosio R, Spaggiari GM, Fortis C, Tambussi G, Dell'Antonio G, Dal Cin E, Rubartelli A, Zocchi MR
J Immunol. 2002
PubMed ID: 11751951
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The septin CDCrel-1 is dispensable for normal development and neurotransmitter release.
Peng XR, Jia Z, Zhang Y, Ware J, Trimble WS
Mol Cell Biol. 2002
PubMed ID: 11739749
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Inducible, pharmacogenetic approaches to the study of learning and memory.
Ohno M, Frankland PW, Chen AP, Costa RM, Silva AJ
Nat Neurosci. 2001
PubMed ID: 11713472
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Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus.
Schell MJ, Erneux C, Irvine RF
J Biol Chem. 2001
PubMed ID: 11468283
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Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1.
Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, Meinander A, Hellman J, Morrice N, MacKintosh C, Morimoto RI, Eriksson JE, Sistonen L
EMBO J. 2001
PubMed ID: 11447121
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Characterization of 5' flanking region of alpha isoform of rat Ca2+/calmodulin-dependent protein kinase II gene and neuronal cell type specific promoter activity.
Mima K, Deguchi S, Yamauchi T
Neurosci Lett. 2001
PubMed ID: 11427314
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Modulation of the G protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding.
Thulin CD, Savage JR, McLaughlin JN, Truscott SM, Old WM, Ahn NG, Resing KA, Hamm HE, Bitensky MW, Willardson BM
J Biol Chem. 2001
PubMed ID: 11331285
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Characterization of a novel synGAP isoform, synGAP-beta.
Li W, Okano A, Tian QB, Nakayama K, Furihata T, Nawa H, Suzuki T
J Biol Chem. 2001
PubMed ID: 11278737
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Interaction with the NMDA receptor locks CaMKII in an active conformation.
Bayer KU, De Koninck P, Leonard AS, Hell JW, Schulman H
Nature. 2001
PubMed ID: 11459059
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Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity.
Fleming I, Fisslthaler B, Dimmeler S, Kemp BE, Busse R
Circ Res. 2001
PubMed ID: 11397791
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Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memory.
Frankland PW, O'Brien C, Ohno M, Kirkwood A, Silva AJ
Nature. 2001
PubMed ID: 11357133
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Identification of a cis-acting dendritic targeting element in the mRNA encoding the alpha subunit of Ca2+/calmodulin-dependent protein kinase II.
Blichenberg A, Rehbein M, Müller R, Garner CC, Richter D, Kindler S
Eur J Neurosci. 2001
PubMed ID: 11403681
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Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current.
Liao GY, Wagner DA, Hsu MH, Leonard JP
Mol Pharmacol. 2001
PubMed ID: 11306676
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Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex.
Gardoni F, Bellone C, Cattabeni F, Di Luca M
J Biol Chem. 2001
PubMed ID: 11104776
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Molecular cloning and sequence analyses of calcium/calmodulin-dependent protein kinase II from fetal and adult human brain. Sequence analyses of human brain calciuum/calmodulin-dependent protein kinase II.
Li G, Laabich A, Liu LO, Xue J, Cooper NG
Mol Biol Rep. 2001
PubMed ID: 11710563
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Hippocampal synaptic plasticity involves competition between Ca2+/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor.
Gardoni F, Schrama LH, Kamal A, Gispen WH, Cattabeni F, Di Luca M
J Neurosci. 2001
PubMed ID: 11222640
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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Tbr1 regulates differentiation of the preplate and layer 6.
Hevner RF, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, Bulfone A, Goffinet AM, Campagnoni AT, Rubenstein JL
Neuron. 2001
PubMed ID: 11239428
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Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding protein.
Wu X, McMurray CT
J Biol Chem. 2001
PubMed ID: 11013247
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Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin.
Walikonis RS, Oguni A, Khorosheva EM, Jeng CJ, Asuncion FJ, Kennedy MB
J Neurosci. 2001
PubMed ID: 11160423
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Ca(2+)/CaM-dependent kinases: from activation to function.
Hook SS, Means AR
Annu Rev Pharmacol Toxicol. 2001
PubMed ID: 11264466
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Two cis-acting elements in the 3' untranslated region of alpha-CaMKII regulate its dendritic targeting.
Mori Y, Imaizumi K, Katayama T, Yoneda T, Tohyama M
Nat Neurosci. 2000
PubMed ID: 11036263
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Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II.
Wicks SJ, Lui S, Abdel-Wahab N, Mason RM, Chantry A
Mol Cell Biol. 2000
PubMed ID: 11027280
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Photoreceptor regulated expression of Ca(2+)/calmodulin-dependent protein kinase II in the mouse retina.
Liu LO, Li G, McCall MA, Cooper NG
Brain Res Mol Brain Res. 2000
PubMed ID: 11042368
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells.
Komeima K, Hayashi Y, Naito Y, Watanabe Y
J Biol Chem. 2000
PubMed ID: 10874031
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Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat.
Szpirer C, Van Vooren P, Rivière M, Scohy S, Collau G, Szpirer J
Mamm Genome. 2000
PubMed ID: 10967130
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The role of alpha-CaMKII autophosphorylation in neocortical experience-dependent plasticity.
Glazewski S, Giese KP, Silva A, Fox K
Nat Neurosci. 2000
PubMed ID: 10966622
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Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.
Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG
Nat Neurosci. 2000
PubMed ID: 10862698
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Expression, purification and characterization of recombinant human choline acetyltransferase: phosphorylation of the enzyme regulates catalytic activity.
Dobransky T, Davis WL, Xiao GH, Rylett RJ
Biochem J. 2000
PubMed ID: 10861222
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CaM-kinases: modulators of synaptic plasticity.
Soderling TR
Curr Opin Neurobiol. 2000
PubMed ID: 10851169
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Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiple sites.
Flück M, Booth FW, Waxham MN
Biochem Biophys Res Commun. 2000
PubMed ID: 10753652
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Dissection of behavior and psychiatric disorders using the mouse as a model.
Tarantino LM, Bucan M
Hum Mol Genet. 2000
PubMed ID: 10767319
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Olfactory based spatial learning in neonatal mice and its dependence on CaMKII.
Wiedenmayer CP, Myers MM, Mayford M, Barr GA
Neuroreport. 2000
PubMed ID: 10790881
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Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta.
Reynolds CH, Betts JC, Blackstock WP, Nebreda AR, Anderton BH
J Neurochem. 2000
PubMed ID: 10737616
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Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10737800
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CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain.
Dragatsis I, Zeitlin S
Genesis. 2000
PubMed ID: 10686608
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Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis.
Inbal B, Shani G, Cohen O, Kissil JL, Kimchi A
Mol Cell Biol. 2000
PubMed ID: 10629061
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Regulation of neuronal nitric-oxide synthase by calmodulin kinases.
Hayashi Y, Nishio M, Naito Y, Yokokura H, Nimura Y, Hidaka H, Watanabe Y
J Biol Chem. 1999
PubMed ID: 10400690
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Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.
Anborgh PH, Qian X, Papageorge AG, Vass WC, DeClue JE, Lowy DR
Mol Cell Biol. 1999
PubMed ID: 10373510
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Developmental expression of the CaM kinase II isoforms: ubiquitous gamma- and delta-CaM kinase II are the early isoforms and most abundant in the developing nervous system.
Bayer KU, Löhler J, Schulman H, Harbers K
Brain Res Mol Brain Res. 1999
PubMed ID: 10381553
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Ca2+/calmodulin-dependent kinase II phosphorylates the epidermal growth factor receptor on multiple sites in the cytoplasmic tail and serine 744 within the kinase domain to regulate signal generation.
Feinmesser RL, Wicks SJ, Taverner CJ, Chantry A
J Biol Chem. 1999
PubMed ID: 10347170
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MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo.
Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill MA, Engel K, Kotlyarov A, Kraft R, Kostka S, Gaestel M, Nordheim A
J Biol Chem. 1999
PubMed ID: 10318869
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Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments.
Schneider A, Biernat J, von Bergen M, Mandelkow E, Mandelkow EM
Biochemistry. 1999
PubMed ID: 10090741
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Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O
DNA Res. 1999
PubMed ID: 10231032
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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Calcium/calmodulin-dependent protein kinase II and calmodulin: regulators of the meiotic spindle in mouse eggs.
Johnson J, Bierle BM, Gallicano GI, Capco DG
Dev Biol. 1998
PubMed ID: 9882483
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New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry.
Hanger DP, Betts JC, Loviny TL, Blackstock WP, Anderton BH
J Neurochem. 1998
PubMed ID: 9832145
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Calcium/calmodulin-dependent protein kinase II controls integrin alpha5beta1-mediated cell adhesion through the integrin cytoplasmic domain associated protein-1alpha.
Bouvard D, Block MR
Biochem Biophys Res Commun. 1998
PubMed ID: 9813144
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Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase.
Wang JZ, Wu Q, Smith A, Grundke-Iqbal I, Iqbal K
FEBS Lett. 1998
PubMed ID: 9771888
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Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.
Sengupta A, Kabat J, Novak M, Wu Q, Grundke-Iqbal I, Iqbal K
Arch Biochem Biophys. 1998
PubMed ID: 9735171
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Characterization of a calmodulin kinase II inhibitor protein in brain.
Chang BH, Mukherji S, Soderling TR
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9724800
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CA1 long-term potentiation is diminished but present in hippocampal slices from alpha-CaMKII mutant mice.
Hinds HL, Tonegawa S, Malinow R
Learn Mem. 1998
PubMed ID: 10454359
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Decreased expression of calmodulin kinase II and calcineurin messenger RNAs in the mouse hippocampus after kainic acid-induced seizures.
Solà C, Tusell JM, Serratosa J
J Neurochem. 1998
PubMed ID: 9523577
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Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning.
Giese KP, Fedorov NB, Filipkowski RK, Silva AJ
Science. 1998
PubMed ID: 9452388
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Abnormal hippocampal spatial representations in alphaCaMKIIT286A and CREBalphaDelta- mice.
Cho YH, Giese KP, Tanila H, Silva AJ, Eichenbaum H
Science. 1998
PubMed ID: 9452387
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Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+.
Wollmuth LP, Kuner T, Sakmann B
J Physiol. 1998
PubMed ID: 9481670
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Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II.
Moyers JS, Bilan PJ, Zhu J, Kahn CR
J Biol Chem. 1997
PubMed ID: 9115241
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Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase.
Kosako H, Amano M, Yanagida M, Tanabe K, Nishi Y, Kaibuchi K, Inagaki M
J Biol Chem. 1997
PubMed ID: 9099667
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Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice.
Kirkwood A, Silva A, Bear MF
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9096402
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The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase.
Paudel HK
J Biol Chem. 1997
PubMed ID: 8999860
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Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus.
Rotenberg A, Mayford M, Hawkins RD, Kandel ER, Muller RU
Cell. 1996
PubMed ID: 8980240
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Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor.
Omkumar RV, Kiely MJ, Rosenstein AJ, Min KT, Kennedy MB
J Biol Chem. 1996
PubMed ID: 8940188
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Control of memory formation through regulated expression of a CaMKII transgene.
Mayford M, Bach ME, Huang YY, Wang L, Hawkins RD, Kandel ER
Science. 1996
PubMed ID: 8939850
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Impaired learning in mice with abnormal short-lived plasticity.
Silva AJ, Rosahl TW, Chapman PF, Marowitz Z, Friedman E, Frankland PW, Cestari V, Cioffi D, Südhof TC, Bourtchuladze R
Curr Biol. 1996
PubMed ID: 8939606
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Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
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Deficient plasticity in the primary visual cortex of alpha-calcium/calmodulin-dependent protein kinase II mutant mice.
Gordon JA, Cioffi D, Silva AJ, Stryker MP
Neuron. 1996
PubMed ID: 8816712
-
Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein.
Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M
J Biol Chem. 1996
PubMed ID: 8663317
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Requirement for alpha-CaMKII in experience-dependent plasticity of the barrel cortex.
Glazewski S, Chen CM, Silva A, Fox K
Science. 1996
PubMed ID: 8602534
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Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cel
Williams CL, Phelps SH, Porter RA
Biochem Pharmacol. 1996
PubMed ID: 8615909
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Ischemia-induced neuronal damage: a role for calcium/calmodulin-dependent protein kinase II.
Waxham MN, Grotta JC, Silva AJ, Strong R, Aronowski J
J Cereb Blood Flow Metab. 1996
PubMed ID: 8530541
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An alternative, nonkinase product of the brain-specifically expressed Ca2+/calmodulin-dependent kinase II alpha isoform gene in skeletal muscle.
Bayer KU, Löhler J, Harbers K
Mol Cell Biol. 1996
PubMed ID: 8524307
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Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestation.
Andersen DL, Tannenberg AE, Burke CJ, Dodd PR
Brain Res Dev Brain Res. 1995
PubMed ID: 8665664
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Calmodulin-dependent protein kinase II is activated transiently in ethanol-stimulated mouse oocytes.
Winston NJ, Maro B
Dev Biol. 1995
PubMed ID: 7649368
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Mutational analysis of Ca(2+)-independent autophosphorylation of calcium/calmodulin-dependent protein kinase II.
Mukherji S, Soderling TR
J Biol Chem. 1995
PubMed ID: 7775466
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Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262.
Drewes G, Trinczek B, Illenberger S, Biernat J, Schmitt-Ulms G, Meyer HE, Mandelkow EM, Mandelkow E
J Biol Chem. 1995
PubMed ID: 7706316
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Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase.
Toyofuku T, Curotto Kurzydlowski K, Narayanan N, MacLennan DH
J Biol Chem. 1994
PubMed ID: 7929371
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Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II.
Chen C, Rainnie DG, Greene RW, Tonegawa S
Science. 1994
PubMed ID: 7939668
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Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization.
Ku NO, Omary MB
J Cell Biol. 1994
PubMed ID: 7523419
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The role of calcium-calmodulin kinase II in three forms of synaptic plasticity.
Stevens CF, Tonegawa S, Wang Y
Curr Biol. 1994
PubMed ID: 7953554
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Identification of phosphorylation sites on glial fibrillary acidic protein for cdc2 kinase and Ca(2+)-calmodulin-dependent protein kinase II.
Tsujimura K, Tanaka J, Ando S, Matsuoka Y, Kusubata M, Sugiura H, Yamauchi T, Inagaki M
J Biochem. 1994
PubMed ID: 7822264
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A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.
Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME
Mol Cell Biol. 1993
PubMed ID: 8413226
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The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein.
Cho KO, Hunt CA, Kennedy MB
Neuron. 1992
PubMed ID: 1419001
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Synaptic vesicle-associated Ca2+/calmodulin-dependent protein kinase II is a binding protein for synapsin I.
Benfenati F, Valtorta F, Rubenstein JL, Gorelick FS, Greengard P, Czernik AJ
Nature. 1992
PubMed ID: 1328883
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A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18.
Justice MJ, Gilbert DJ, Kinzler KW, Vogelstein B, Buchberg AM, Ceci JD, Matsuda Y, Chapman VM, Patriotis C, Makris A
Genomics. 1992
PubMed ID: 1354644
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Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice.
Silva AJ, Stevens CF, Tonegawa S, Wang Y
Science. 1992
PubMed ID: 1378648
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Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice.
Silva AJ, Paylor R, Wehner JM, Tonegawa S
Science. 1992
PubMed ID: 1321493
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Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.
Bredt DS, Ferris CD, Snyder SH
J Biol Chem. 1992
PubMed ID: 1375933
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PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18.
Omary MB, Baxter GT, Chou CF, Riopel CL, Lin WY, Strulovici B
J Cell Biol. 1992
PubMed ID: 1374067
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Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta.
Wegner M, Cao Z, Rosenfeld MG
Science. 1992
PubMed ID: 1314426
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Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.
Countaway JL, Nairn AC, Davis RJ
J Biol Chem. 1992
PubMed ID: 1309762
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Alpha calcium/calmodulin kinase II mutant mice: deficient long-term potentiation and impaired spatial learning.
Silva AJ, Wang Y, Paylor R, Wehner JM, Stevens CF, Tonegawa S
Cold Spring Harb Symp Quant Biol. 1992
PubMed ID: 1339689
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Chromosomal localization of the murine genes for the alpha- and beta-subunits of calcium/calmodulin-dependent protein kinase II.
Danciger M, Kozak CA, Adamson MC, Farber DB
Mamm Genome. 1992
PubMed ID: 1319776
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Protein kinase A phosphorylates retinal phosducin on serine 73 in situ.
Lee RH, Brown BM, Lolley RN
J Biol Chem. 1990
PubMed ID: 2394752
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Ca2+/calmodulin-dependent protein kinase II: localization in the interphase nucleus and the mitotic apparatus of mammalian cells.
Ohta Y, Ohba T, Miyamoto E
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2164678
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Ca2(+)-calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteins.
Tokui T, Yamauchi T, Yano T, Nishi Y, Kusagawa M, Yatani R, Inagaki M
Biochem Biophys Res Commun. 1990
PubMed ID: 2114109
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Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-alpha-helical head domain.
Inagaki M, Gonda Y, Nishizawa K, Kitamura S, Sato C, Ando S, Tanabe K, Kikuchi K, Tsuiki S, Nishi Y
J Biol Chem. 1990
PubMed ID: 2155236
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Sequence analysis and DNA-protein interactions within the 5' flanking region of the Ca2+/calmodulin-dependent protein kinase II alpha-subunit gene.
Sunyer T, Sahyoun N
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2153289
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Studies of the regulatory mechanism of Ca2+/calmodulin-dependent protein kinase II. Mutation of threonine 286 to alanine and aspartate.
Fong YL, Taylor WL, Means AR, Soderling TR
J Biol Chem. 1989
PubMed ID: 2550458
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Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain.
Hanley RM, Payne ME, Cruzalegui F, Christenson MA, Means AR
Nucleic Acids Res. 1989
PubMed ID: 2543961
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Ca2+/calmodulin-dependent protein kinase II: identification of threonine-286 as the autophosphorylation site in the alpha subunit associated with the generation of Ca2+-independent activity.
Thiel G, Czernik AJ, Gorelick F, Nairn AC, Greengard P
Proc Natl Acad Sci U S A. 1988
PubMed ID: 2842767
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Conserved and variable regions in the subunits of brain type II Ca2+/calmodulin-dependent protein kinase.
Bulleit RF, Bennett MK, Molloy SS, Hurley JB, Kennedy MB
Neuron. 1988
PubMed ID: 2856087
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Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.
Lin CR, Kapiloff MS, Durgerian S, Tatemoto K, Russo AF, Hanson P, Schulman H, Rosenfeld MG
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3475713
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Functional analysis of a complementary DNA for the 50-kilodalton subunit of calmodulin kinase II.
Hanley RM, Means AR, Ono T, Kemp BE, Burgin KE, Waxham N, Kelly PT
Science. 1987
PubMed ID: 3037704
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