Home CUBN
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(Human) GRCh37 - chr10:16865963..17171830 (305.87 kb) View in Genome Browser
(Mouse) NCBIM37 - chr2:13197965..13413551 (215.59 kb) View in Genome Browser
(Rat) RGSC3.4 - chr17:87545893..87772079 (226.19 kb) View in Genome Browser
HaemAtlas Expression Table for CUBN:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for CUBN:The CUBN interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| CUBN | ALB | HPRD | empirical | 10811843 |
| CUBN | RRP1B | BioGRID | empirical | 19710015 |
| CUBN | GC | HPRD, Reactome | empirical | 11717447 11085925 9821970 |
| CUBN | GIF | HPRD, IntAct, BioGRID | empirical | 9572993 20237569 |
| CUBN | LGALS3 | HPRD | empirical | 11856751 |
| CUBN | LRP2 | HPRD | empirical | 11994745 11595644 |
| CUBN | POU5F1 | IntAct, BioGRID | empirical | 20362542 |
| CUBN | TF | HPRD | empirical | 11606717 |
| CUBN | SCGB1A1 | HPRD, BioGRID | empirical | 11278724 |
| CUBN | CUBN | IntAct | empirical | 20237569 |
| CUBN | AMN | Reactome | predicted |
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Type 1 Diabetes Publications: 4
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CUBN Is a Gene Locus for Albuminuria.
Böger CA, Chen MH, Tin A, Olden M, Köttgen A, Deboer IH, Fuchsberger C, O'Seaghdha CM, Pattaro C, Teumer A, Liu CT, Glazer NL, Li M, O'Connell JR, Tanaka T, Peralta CA, Kutalik Z, Luan J, Zhao JH, Hwang SJ, Akylbekova E, Kramer H, van der Harst P, Smith AV, Lohman K, de Andrade M, Hayward C, Kollerits B, Tönjes A, Aspelund T, Ingelsson E, Eiriksdottir G, Launer LJ, Harris TB, Shuldiner AR, Mitchell BD, Arking DE, Franceschini N, Boerwinkle E, Egan J, Hernandez D, Reilly M, Townsend RR, Lumley T, Siscovick DS, Psaty BM, Kestenbaum B, Haritunians T, Bergmann S, Vollenweider P, Waeber G, Mooser V, Waterworth D, Johnson AD, Florez JC, Meigs JB, Lu X, Turner ST, Atkinson EJ, Leak TS, Aasarød K, Skorpen F, Syvänen AC, Illig T, Baumert J, Koenig W, Krämer BK, Devuyst O, Mychaleckyj JC, Minelli C, Bakker SJ, Kedenko L, Paulweber B, Coassin S, Endlich K, Kroemer HK, Biffar R, Stracke S, Völzke H, Stumvoll M, Mägi R, Campbell H, Vitart V, Hastie ND, Gudnason V, Kardia SL, Liu Y, Polasek O, Curhan G, Kronenberg F, Prokopenko I, Rudan I, Arnlöv J, Hallan S, Navis G, the CKDGen Consortium, Parsa A, Ferrucci L, Coresh J, Shlipak MG, Bull SB, Paterson AD, Paterson on behalf of DCCT/EDIC, Wichmann HE, Wareham NJ, Loos RJ, Rotter JI, Pramstaller PP, Cupples LA, Beckmann JS, Yang Q, Heid IM, Rettig R, Dreisbach AW, Bochud M, Fox CS, Kao WH
J Am Soc Nephrol. 2011
PubMed ID: 21355061
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The role of cubilin gene polymorphisms and their influence on 25(OH)D(3) and 1,25(OH)(2)D(3) plasma levels in type 1 diabetes patients.
Ramos-Lopez E, Lange B, Penna-Martinez M, Brück P, Swiech K, Mauf S, Kahles H, Badenhoop K
J Steroid Biochem Mol Biol. 2010
PubMed ID: 20398757
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Microalbuminuria in type 1 diabetes mellitus is associated with enhanced excretion of the endocytic, multiligand receptors megalin and cubilin.
Thrailkill KM, Nimmo T, Bunn RC, Cockrell GE, Moreau CS, Mackintosh S, Edmondson RD, Fowlkes JL
Diabetes Care. 2009
PubMed ID: 19366958
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Global expression analysis of gene regulatory pathways during endocrine pancreatic development.
Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA
Development. 2004
PubMed ID: 14660441
Publications: 101
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Luminal expression of cubilin is impaired in Imerslund-Grasbeck syndrome with compound AMN mutations in intron 3 and exon 7.
Namour F, Dobrovoljski G, Chery C, Audonnet S, Feillet F, Sperl W, Gueant JL
Haematologica. 2011
PubMed ID: 21750092
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Exome sequencing reveals cubilin mutation as a single-gene cause of proteinuria.
Ovunc B, Otto EA, Vega-Warner V, Saisawat P, Ashraf S, Ramaswami G, Fathy HM, Schoeb D, Chernin G, Lyons RH, Yilmaz E, Hildebrandt F
J Am Soc Nephrol. 2011
PubMed ID: 21903995
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Role of megalin and cubilin in the metabolism of vitamin D(3).
Kaseda R, Hosojima M, Sato H, Saito A
Ther Apher Dial. 2011
PubMed ID: 21595846
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Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.
Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D, Lin ML, Teague J, Bignell G, Butler A, Cho J, Dalgliesh GL, Galappaththige D, Greenman C, Hardy C, Jia M, Latimer C, Lau KW, Marshall J, McLaren S, Menzies A, Mudie L, Stebbings L, Largaespada DA, Wessels LF, Richard S, Kahnoski RJ, Anema J, Tuveson DA, Perez-Mancera PA, Mustonen V, Fischer A, Adams DJ, Rust A, Chan-on W, Subimerb C, Dykema K, Furge K, Campbell PJ, Teh BT, Stratton MR, Futreal PA
Nature. 2011
PubMed ID: 21248752
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Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs.
Wang Q, Chow J, Hong J, Smith AF, Moreno C, Seaby P, Vrana P, Miri K, Tak J, Chung ED, Mastromonaco G, Caniggia I, Varmuza S
BMC Genomics. 2011
PubMed ID: 21510876
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.
Peloso GM, Demissie S, Collins D, Mirel DB, Gabriel SB, Cupples LA, Robins SJ, Schaefer EJ, Brousseau ME
J Lipid Res. 2010
PubMed ID: 20855565
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Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
Furney SJ, Simmons A, Breen G, Pedroso I, Lunnon K, Proitsi P, Hodges A, Powell J, Wahlund LO, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Spenger C, Lathrop M, Shen L, Kim S, Saykin AJ, Weiner MW, Lovestone S
Mol Psychiatry. 2010
PubMed ID: 21116278
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Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer.
Collin SM, Metcalfe C, Refsum H, Lewis SJ, Smith GD, Cox A, Davis M, Marsden G, Johnston C, Lane JA, Donovan JL, Neal DE, Hamdy FC, Smith AD, Martin RM
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20852008
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Cubilin is essential for albumin reabsorption in the renal proximal tubule.
Amsellem S, Gburek J, Hamard G, Nielsen R, Willnow TE, Devuyst O, Nexo E, Verroust PJ, Christensen EI, Kozyraki R
J Am Soc Nephrol. 2010
PubMed ID: 20798259
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O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.
Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC
Dev Biol. 2010
PubMed ID: 20637190
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Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
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A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.
Levine AJ, Figueiredo JC, Lee W, Conti DV, Kennedy K, Duggan DJ, Poynter JN, Campbell PT, Newcomb P, Martinez ME, Hopper JL, Le Marchand L, Baron JA, Limburg PJ, Ulrich CM, Haile RW
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20615890
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Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
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An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.
Pardo M, Lang B, Yu L, Prosser H, Bradley A, Babu MM, Choudhary J
Cell Stem Cell. 2010
PubMed ID: 20362542
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Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes.
Andersen CB, Madsen M, Storm T, Moestrup SK, Andersen GR
Nature. 2010
PubMed ID: 20237569
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Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.
Quina LA, Wang S, Ng L, Turner EE
J Neurosci. 2009
PubMed ID: 19906978
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Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
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The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.
Crawford NP, Yang H, Mattaini KR, Hunter KW
J Biol Chem. 2009
PubMed ID: 19710015
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
Wollscheid B, Bausch-Fluck D, Henderson C, O'Brien R, Bibel M, Schiess R, Aebersold R, Watts JD
Nat Biotechnol. 2009
PubMed ID: 19349973
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Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
Tanaka T, Scheet P, Giusti B, Bandinelli S, Piras MG, Usala G, Lai S, Mulas A, Corsi AM, Vestrini A, Sofi F, Gori AM, Abbate R, Guralnik J, Singleton A, Abecasis GR, Schlessinger D, Uda M, Ferrucci L
Am J Hum Genet. 2009
PubMed ID: 19303062
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The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.
Nada S, Hondo A, Kasai A, Koike M, Saito K, Uchiyama Y, Okada M
EMBO J. 2009
PubMed ID: 19177150
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An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).
Franke B, Vermeulen SH, Steegers-Theunissen RP, Coenen MJ, Schijvenaars MM, Scheffer H, den Heijer M, Blom HJ
Birth Defects Res A Clin Mol Teratol. 2009
PubMed ID: 19161160
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Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
Lowe JK, Maller JB, Pe'er I, Neale BM, Salit J, Kenny EE, Shea JL, Burkhardt R, Smith JG, Ji W, Noel M, Foo JN, Blundell ML, Skilling V, Garcia L, Sullivan ML, Lee HE, Labek A, Ferdowsian H, Auerbach SB, Lifton RP, Newton-Cheh C, Breslow JL, Stoffel M, Daly MJ, Altshuler DM, Friedman JM
PLoS Genet. 2009
PubMed ID: 19197348
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Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.
Chen SN, Cilingiroglu M, Todd J, Lombardi R, Willerson JT, Gotto AM, Ballantyne CM, Marian AJ
BMC Med Genet. 2009
PubMed ID: 19878569
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Cubilin and megalin co-localize in the neonatal inner ear.
Tauris J, Christensen EI, Nykjaer A, Jacobsen C, Petersen CM, Ovesen T
Audiol Neurootol. 2009
PubMed ID: 19202329
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Megalin and cubilin in the human gallbladder epithelium.
Tsaroucha AK, Chatzaki E, Lambropoulou M, Despoudi K, Laftsidis P, Charsou C, Polychronidis A, Papadopoulos N, Simopoulos CE
Clin Exp Med. 2008
PubMed ID: 18791690
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Silencing megalin and cubilin genes inhibits myeloma light chain endocytosis and ameliorates toxicity in human renal proximal tubule epithelial cells.
Li M, Balamuthusamy S, Simon EE, Batuman V
Am J Physiol Renal Physiol. 2008
PubMed ID: 18448595
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Interactions of cubilin with megalin and the product of the amnionless gene (AMN): effect on its stability.
Ahuja R, Yammani R, Bauer JA, Kalra S, Seetharam S, Seetharam B
Biochem J. 2008
PubMed ID: 17990981
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Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst.
Gerbe F, Cox B, Rossant J, Chazaud C
Dev Biol. 2008
PubMed ID: 18083160
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Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex.
Gelineau-van Waes J, Maddox JR, Smith LM, van Waes M, Wilberding J, Eudy JD, Bauer LK, Finnell RH
BMC Genomics. 2008
PubMed ID: 18400109
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Age-related change of endocytic receptors megalin and cubilin in the kidney in rats.
Odera K, Goto S, Takahashi R
Biogerontology. 2007
PubMed ID: 17453355
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Cobalamin-mediated regulation of transcobalamin receptor levels in rat organs.
Kalra S, Ahuja R, Mutti E, Veber D, Seetharam S, Scalabrino G, Seetharam B
Arch Biochem Biophys. 2007
PubMed ID: 17442257
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Mechanisms of discrimination between cobalamins and their natural analogues during their binding to the specific B12-transporting proteins.
Fedosov SN, Fedosova NU, Kräutler B, Nexø E, Petersen TE
Biochemistry. 2007
PubMed ID: 17487979
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Identification of the ligands of protein interaction domains through a functional approach.
Caratù G, Allegra D, Bimonte M, Schiattarella GG, D'Ambrosio C, Scaloni A, Napolitano M, Russo T, Zambrano N
Mol Cell Proteomics. 2007
PubMed ID: 17124247
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Multiligand endocytosis and congenital defects: roles of cubilin, megalin and amnionless.
Kozyraki R, Gofflot F
Curr Pharm Des. 2007
PubMed ID: 17979745
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A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE).
Hou J, Charters AM, Lee SC, Zhao Y, Wu MK, Jones SJ, Marra MA, Hoodless PA
BMC Dev Biol. 2007
PubMed ID: 17683524
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Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation.
Frankenberg S, Smith L, Greenfield A, Zernicka-Goetz M
BMC Dev Biol. 2007
PubMed ID: 17302988
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PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.
Yoshida Y, Han B, Mendelsohn M, Jessell TM
Neuron. 2006
PubMed ID: 17145500
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The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
Science. 2006
PubMed ID: 16959974
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A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.
Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA
Development. 2006
PubMed ID: 16971476
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[Expression level of cubilin in the rat model of diabetic nephropathy].
Feng M, Zhang Z, Fu P, Huang SM, Yang YB, Su KL, Chen ZJ, Tang WX
Sichuan Da Xue Xue Bao Yi Xue Ban. 2006
PubMed ID: 17037740
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BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
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Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation.
Smith BT, Mussell JC, Fleming PA, Barth JL, Spyropoulos DD, Cooley MA, Drake CJ, Argraves WS
BMC Dev Biol. 2006
PubMed ID: 16787536
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A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A
Am J Hum Genet. 2006
PubMed ID: 16385451
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Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay.
Osafune K, Takasato M, Kispert A, Asashima M, Nishinakamura R
Development. 2006
PubMed ID: 16319116
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Overlapping expression patterns of the multiligand endocytic receptors cubilin and megalin in the CNS, sensory organs and developing epithelia of the rodent embryo.
Assémat E, Châtelet F, Chandellier J, Commo F, Cases O, Verroust P, Kozyraki R
Gene Expr Patterns. 2005
PubMed ID: 16027047
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Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein.
Maurer ME, Cooper JA
J Cell Sci. 2005
PubMed ID: 16263760
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
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Science. 2005
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Am J Physiol Renal Physiol. 2005
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Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo.
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Biol Reprod. 2005
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Biochemistry. 2005
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Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones.
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Endocr Rev. 2004
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Cell Tissue Res. 2004
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Nature. 2004
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Anat Rec A Discov Mol Cell Evol Biol. 2004
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Blood. 2004
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Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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Am J Physiol Renal Physiol. 2003
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Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules.
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Proc Natl Acad Sci U S A. 2003
PubMed ID: 12815097
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Pediatr Nephrol. 2003
PubMed ID: 12687456
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PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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Nature. 2002
PubMed ID: 12466851
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Cubilin, a binding partner for galectin-3 in the murine utero-placental complex.
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J Biol Chem. 2002
PubMed ID: 11856751
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Nat Rev Mol Cell Biol. 2002
PubMed ID: 11994745
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Comparative analysis of cobalamin binding kinetics and ligand protection for intrinsic factor, transcobalamin, and haptocorrin.
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J Biol Chem. 2002
PubMed ID: 11788601
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Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin.
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J Am Soc Nephrol. 2002
PubMed ID: 11805171
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Identification and characterization of two distinct ligand binding regions of cubilin.
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J Biol Chem. 2001
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Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).
Nykjaer A, Fyfe JC, Kozyraki R, Leheste JR, Jacobsen C, Nielsen MS, Verroust PJ, Aminoff M, de la Chapelle A, Moestrup SK, Ray R, Gliemann J, Willnow TE, Christensen EI
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11717447
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Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy.
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Am J Physiol Endocrinol Metab. 2001
PubMed ID: 11595644
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Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia.
Kozyraki R, Fyfe J, Verroust PJ, Jacobsen C, Dautry-Varsat A, Gburek J, Willnow TE, Christensen EI, Moestrup SK
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11606717
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Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
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Genome Res. 2001
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A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney.
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J Biol Chem. 2001
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Functional annotation of a full-length mouse cDNA collection.
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Nature. 2001
PubMed ID: 11217851
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
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Genome Res. 2000
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
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Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B(12) by cubilin.
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Blood. 2000
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Cubilin is an albumin binding protein important for renal tubular albumin reabsorption.
Birn H, Fyfe JC, Jacobsen C, Mounier F, Verroust PJ, Orskov H, Willnow TE, Moestrup SK, Christensen EI
J Clin Invest. 2000
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Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins.
Hammad SM, Barth JL, Knaak C, Argraves WS
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Genetic evidence of an accessory activity required specifically for cubilin brush-border expression and intrinsic factor-cobalamin absorption.
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Blood. 1999
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Molecular dissection of the intrinsic factor-vitamin B12 receptor, cubilin, discloses regions important for membrane association and ligand binding.
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J Biol Chem. 1999
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The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein.
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Nat Med. 1999
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The intrinsic factor-vitamin B12 receptor, cubilin, is assembled into trimers via a coiled-coil alpha-helix.
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Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1.
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