Home DEK
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Regions Overlapping this Feature:
Mouse: 1
Rat: 2
Linkage Regions: 2 Available
Other Regions: 1 Available
Linkage Regions: 2 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes | Linkage and Congenic Studies |
|---|---|---|---|---|---|
| Idd14 | Mouse | chr13:25424067..120284312 | 94.86 | 733 | 1 no lod score |
| Iddm20 | Rat | chr17:19877005..27819082 | 7.94 | 62 | 1 Significant for backcross |
Other Regions: 1 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes |
|---|---|---|---|---|
| Iddm36 | Rat | chr17:22932286..47628829 | 24.70 | 149 |
(Human) GRCh37 - chr6:18224099..18265054 (40.95 kb) View in Genome Browser
(Mouse) NCBIM37 - chr13:47180136..47201589 (21.45 kb) View in Genome Browser
(Rat) RGSC3.4 - chr17:23633551..23655507 (21.96 kb) View in Genome Browser
HaemAtlas Expression Table for DEK:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for DEK:The DEK interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| DEK | SRRM1 | HPRD, BioGRID | empirical | 10908574 |
| DEK | CREBBP | BioGRID | empirical | 15987677 |
| DEK | CSNK2A1 | IntAct | empirical | 22113938 |
| DEK | AP2A1 | HPRD | empirical | 12595566 |
| DEK | DAXX | IntAct, BioGRID | empirical | 12140263 |
| DEK | KHDRBS2 | BioGRID | empirical | 17643375 |
| DEK | EP300 | BioGRID | empirical | 15987677 |
| DEK | ESR1 | IntAct | empirical | 21182205 |
| DEK | ZIK1 | HPRD | empirical | 8910362 |
| DEK | TLX3 | BioGRID | empirical | 20211142 |
| DEK | HIST1H1A | BioGRID | empirical | 16696975 |
| DEK | HDAC2 | IntAct, BioGRID | empirical | 12140263 |
| DEK | HLA-A | HPRD | empirical | 9684994 |
| DEK | UPF1 | IntAct | empirical | 11546874 |
| DEK | SRSF2 | BioGRID | empirical | 10908574 |
| DEK | TFAP2A | HPRD, BioGRID | empirical | 12595566 |
| DEK | UBC | BioGRID | empirical | 21139048 21890473 21906983 |
| DEK | DEK | HPRD | empirical | 15199153 |
| DEK | HIST2H2AC | BioGRID | empirical | 16696975 |
| DEK | HIST2H2BE | BioGRID | empirical | 16696975 |
| DEK | HIST1H3A | BioGRID | empirical | 16696975 |
| DEK | HIST1H4A | BioGRID | empirical | 16696975 12140263 |
| DEK | KAT2B | BioGRID | empirical | 15987677 |
| DEK | BAZ1B | BioGRID | empirical | 16603771 |
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Publications: 113
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The human DEK oncogene regulates DNA damage response signaling and repair.
Kavanaugh GM, Wise-Draper TM, Morreale RJ, Morrison MA, Gole B, Schwemberger S, Tichy ED, Lu L, Babcock GF, Wells JM, Drissi R, Bissler JJ, Stambrook PJ, Andreassen PR, Wiesmüller L, Wells SI
Nucleic Acids Res. 2011
PubMed ID: 21653549
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DEK expression in melanocytic lesions.
Kappes F, Khodadoust MS, Yu L, Kim DS, Fullen DR, Markovitz DM, Ma L
Hum Pathol. 2011
PubMed ID: 21316078
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A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
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The human DEK oncogene stimulates β-catenin signaling, invasion and mammosphere formation in breast cancer.
Privette Vinnedge LM, McClaine R, Wagh PK, Wikenheiser-Brokamp KA, Waltz SE, Wells SI
Oncogene. 2011
PubMed ID: 21317931
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The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity.
Kappes F, Waldmann T, Mathew V, Yu J, Zhang L, Khodadoust MS, Chinnaiyan AM, Luger K, Erhardt S, Schneider R, Markovitz DM
Genes Dev. 2011
PubMed ID: 21460035
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DEK in the synovium of patients with juvenile idiopathic arthritis: characterization of DEK antibodies and posttranslational modification of the DEK autoantigen.
Mor-Vaknin N, Kappes F, Dick AE, Legendre M, Damoc C, Teitz-Tennenbaum S, Kwok R, Ferrando-May E, Adams BS, Markovitz DM
Arthritis Rheum. 2011
PubMed ID: 21280010
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Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.
Campbell GR, Baudhuin A, Vranizan K, Ngai J
Mol Cell Neurosci. 2011
PubMed ID: 21194568
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Oncoprotein DEK as a tissue and urinary biomarker for bladder cancer.
Datta A, Adelson ME, Mogilevkin Y, Mordechai E, Sidi AA, Trama JP
BMC Cancer. 2011
PubMed ID: 21663673
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Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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The t(6;9) associated DEK/CAN fusion protein targets a population of long-term repopulating hematopoietic stem cells for leukemogenic transformation.
Oancea C, Rüster B, Henschler R, Puccetti E, Ruthardt M
Leukemia. 2010
PubMed ID: 20827285
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High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length.
Fahrer J, Popp O, Malanga M, Beneke S, Markovitz DM, Ferrando-May E, Bürkle A, Kappes F
Biochemistry. 2010
PubMed ID: 20669926
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DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung.
Shibata T, Kokubu A, Miyamoto M, Hosoda F, Gotoh M, Tsuta K, Asamura H, Matsuno Y, Kondo T, Imoto I, Inazawa J, Hirohashi S
Oncogene. 2010
PubMed ID: 20543864
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Control of tumorigenesis and chemoresistance by the DEK oncogene.
Riveiro-Falkenbach E, Soengas MS
Clin Cancer Res. 2010
PubMed ID: 20501624
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Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Dev Cell. 2010
PubMed ID: 20412781
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The oncogene DEK promotes leukemic cell survival and is downregulated by both Nutlin-3 and chlorambucil in B-chronic lymphocytic leukemic cells.
Secchiero P, Voltan R, di Iasio MG, Melloni E, Tiribelli M, Zauli G
Clin Cancer Res. 2010
PubMed ID: 20215548
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An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
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A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor.
Sawatsubashi S, Murata T, Lim J, Fujiki R, Ito S, Suzuki E, Tanabe M, Zhao Y, Kimura S, Fujiyama S, Ueda T, Umetsu D, Ito T, Takeyama K, Kato S
Genes Dev. 2010
PubMed ID: 20040570
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A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
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Melanoma proliferation and chemoresistance controlled by the DEK oncogene.
Khodadoust MS, Verhaegen M, Kappes F, Riveiro-Falkenbach E, Cigudosa JC, Kim DS, Chinnaiyan AM, Markovitz DM, Soengas MS
Cancer Res. 2009
PubMed ID: 19679545
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Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
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Proteome analysis of human nuclear insoluble fractions.
Takata H, Nishijima H, Ogura S, Sakaguchi T, Bubulya PA, Mochizuki T, Shibahara K
Genes Cells. 2009
PubMed ID: 19695025
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Clinicopathological significance of DEK overexpression in serous ovarian tumors.
Han S, Xuan Y, Liu S, Zhang M, Jin D, Jin R, Lin Z
Pathol Int. 2009
PubMed ID: 19563407
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Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Proteomic analysis of apoptosis related proteins regulated by proto-oncogene protein DEK.
Kim DW, Chae JI, Kim JY, Pak JH, Koo DB, Bahk YY, Seo SB
J Cell Biochem. 2009
PubMed ID: 19229864
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Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo.
Wise-Draper TM, Mintz-Cole RA, Morris TA, Simpson DS, Wikenheiser-Brokamp KA, Currier MA, Cripe TP, Grosveld GC, Wells SI
Cancer Res. 2009
PubMed ID: 19223548
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DEK proto-oncogene expression interferes with the normal epithelial differentiation program.
Wise-Draper TM, Morreale RJ, Morris TA, Mintz-Cole RA, Hoskins EE, Balsitis SJ, Husseinzadeh N, Witte DP, Wikenheiser-Brokamp KA, Lambert PF, Wells SI
Am J Pathol. 2009
PubMed ID: 19036808
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Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.
Wang B, Malik R, Nigg EA, Körner R
Anal Chem. 2008
PubMed ID: 19007248
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Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
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Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
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A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
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DEK overexpression in uterine cervical cancers.
Wu Q, Li Z, Lin H, Han L, Liu S, Lin Z
Pathol Int. 2008
PubMed ID: 18477217
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DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress.
Kappes F, Fahrer J, Khodadoust MS, Tabbert A, Strasser C, Mor-Vaknin N, Moreno-Villanueva M, Bürkle A, Markovitz DM, Ferrando-May E
Mol Cell Biol. 2008
PubMed ID: 18332104
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Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
Han G, Ye M, Zhou H, Jiang X, Feng S, Jiang X, Tian R, Wan D, Zou H, Gu J
Proteomics. 2008
PubMed ID: 18318008
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Caspase-dependent apoptosis induction by targeted expression of DEK in Drosophila involves histone acetylation inhibition.
Lee KS, Kim DW, Kim JY, Choo JK, Yu K, Seo SB
J Cell Biochem. 2008
PubMed ID: 17685435
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Solution NMR structure of the N-terminal domain of the human DEK protein.
Devany M, Kappes F, Chen KM, Markovitz DM, Matsuo H
Protein Sci. 2008
PubMed ID: 18227428
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Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD
J Proteome Res. 2007
PubMed ID: 17924679
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A differential phosphoproteomic analysis of retinoic acid-treated P19 cells.
Smith JC, Duchesne MA, Tozzi P, Ethier M, Figeys D
J Proteome Res. 2007
PubMed ID: 17622165
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Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.
Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B
Mol Cell. 2007
PubMed ID: 17643375
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The distribution of the DEK protein in mammalian chromatin.
Hu HG, Scholten I, Gruss C, Knippers R
Biochem Biophys Res Commun. 2007
PubMed ID: 17524367
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Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.
Molina H, Horn DM, Tang N, Mathivanan S, Pandey A
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17287340
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Serum from mice immunized in the context of Treg inhibition identifies DEK as a neuroblastoma tumor antigen.
Zheng J, Kohler ME, Chen Q, Weber J, Khan J, Johnson BD, Orentas RJ
BMC Immunol. 2007
PubMed ID: 17397536
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The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity.
Ouararhni K, Hadj-Slimane R, Ait-Si-Ali S, Robin P, Mietton F, Harel-Bellan A, Dimitrov S, Hamiche A
Genes Dev. 2006
PubMed ID: 17158748
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The DEK nuclear autoantigen is a secreted chemotactic factor.
Mor-Vaknin N, Punturieri A, Sitwala K, Faulkner N, Legendre M, Khodadoust MS, Kappes F, Ruth JH, Koch A, Glass D, Petruzzelli L, Adams BS, Markovitz DM
Mol Cell Biol. 2006
PubMed ID: 17030615
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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
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Apoptosis inhibition by the human DEK oncoprotein involves interference with p53 functions.
Wise-Draper TM, Allen HV, Jones EE, Habash KB, Matsuo H, Wells SI
Mol Cell Biol. 2006
PubMed ID: 16894028
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Negative regulation of the RelA/p65 transactivation function by the product of the DEK proto-oncogene.
Sammons M, Wan SS, Vogel NL, Mientjes EJ, Grosveld G, Ashburner BP
J Biol Chem. 2006
PubMed ID: 16829531
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Intron removal requires proofreading of U2AF/3' splice site recognition by DEK.
Soares LM, Zanier K, Mackereth C, Sattler M, Valcárcel J
Science. 2006
PubMed ID: 16809543
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The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.
Cavellán E, Asp P, Percipalle P, Farrants AK
J Biol Chem. 2006
PubMed ID: 16603771
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DEK Expression is controlled by E2F and deregulated in diverse tumor types.
Carro MS, Spiga FM, Quarto M, Di Ninni V, Volorio S, Alcalay M, Müller H
Cell Cycle. 2006
PubMed ID: 16721057
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Regulation of histone acetyltransferase activity of p300 and PCAF by proto-oncogene protein DEK.
Ko SI, Lee IS, Kim JY, Kim SM, Kim DW, Lee KS, Woo KM, Baek JH, Choo JK, Seo SB
FEBS Lett. 2006
PubMed ID: 16696975
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The involvement of cellular proliferation status in the expression of the human proto-oncogene DEK.
Ageberg M, Gullberg U, Lindmark A
Haematologica. 2006
PubMed ID: 16461319
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Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
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High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization.
Yoshikawa T, Piao Y, Zhong J, Matoba R, Carter MG, Wang Y, Goldberg I, Ko MS
Gene Expr Patterns. 2006
PubMed ID: 16325481
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Expression analysis of 6p22 genomic gain in retinoblastoma.
Orlic M, Spencer CE, Wang L, Gallie BL
Genes Chromosomes Cancer. 2006
PubMed ID: 16180235
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The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7.
Wise-Draper TM, Allen HV, Thobe MN, Jones EE, Habash KB, Münger K, Wells SI
J Virol. 2005
PubMed ID: 16254365
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Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma.
Grasemann C, Gratias S, Stephan H, Schüler A, Schramm A, Klein-Hitpass L, Rieder H, Schneider S, Kappes F, Eggert A, Lohmann DR
Oncogene. 2005
PubMed ID: 16007192
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p300/CBP-associated factor drives DEK into interchromatin granule clusters.
Cleary J, Sitwala KV, Khodadoust MS, Kwok RP, Mor-Vaknin N, Cebrat M, Cole PA, Markovitz DM
J Biol Chem. 2005
PubMed ID: 15987677
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
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Science. 2005
PubMed ID: 16141072
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Distribution of the chromatin protein DEK distinguishes active and inactive CD21/CR2 gene in pre- and mature B lymphocytes.
Hu HG, Illges H, Gruss C, Knippers R
Int Immunol. 2005
PubMed ID: 15908448
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Expression and isotopic labeling of structural domains of the human protein DEK.
Devany M, Kotharu NP, Matsuo H
Protein Expr Purif. 2005
PubMed ID: 15766865
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The SAF-box domain of chromatin protein DEK.
Böhm F, Kappes F, Scholten I, Richter N, Matsuo H, Knippers R, Waldmann T
Nucleic Acids Res. 2005
PubMed ID: 15722484
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NMR resonance assignments for the DNA-supercoiling domain of the human protein DEK.
Devany M, Matsuo H
J Biomol NMR. 2005
PubMed ID: 15692740
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Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
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The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin.
Waldmann T, Scholten I, Kappes F, Hu HG, Knippers R
Gene. 2004
PubMed ID: 15563827
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Evidence for a novel rheumatoid arthritis susceptibility locus on chromosome 6p.
Brintnell W, Zeggini E, Barton A, Thomson W, Eyre S, Hinks A, Silman AJ, Worthington J
Arthritis Rheum. 2004
PubMed ID: 15593216
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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Solution NMR structure of the C-terminal domain of the human protein DEK.
Devany M, Kotharu NP, Matsuo H
Protein Sci. 2004
PubMed ID: 15238633
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Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK.
Kappes F, Damoc C, Knippers R, Przybylski M, Pinna LA, Gruss C
Mol Cell Biol. 2004
PubMed ID: 15199154
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Functional domains of the ubiquitous chromatin protein DEK.
Kappes F, Scholten I, Richter N, Gruss C, Waldmann T
Mol Cell Biol. 2004
PubMed ID: 15199153
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Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW
Nat Biotechnol. 2004
PubMed ID: 15146197
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
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Structure-specific binding of the proto-oncogene protein DEK to DNA.
Waldmann T, Baack M, Richter N, Gruss C
Nucleic Acids Res. 2003
PubMed ID: 14627833
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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Aberrant expression of HOXA9, DEK, CBL and CSF1R in acute myeloid leukemia.
Casas S, Nagy B, Elonen E, Aventín A, Larramendy ML, Sierra J, Ruutu T, Knuutila S
Leuk Lymphoma. 2003
PubMed ID: 14738146
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The DNA sequence and analysis of human chromosome 6.
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Nature. 2003
PubMed ID: 14574404
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A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
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Transcriptional activation by AP-2alpha is modulated by the oncogene DEK.
Campillos M, García MA, Valdivieso F, Vázquez J
Nucleic Acids Res. 2003
PubMed ID: 12595566
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BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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YY1 and NF-Y binding sites regulate the transcriptional activity of the dek and dek-can promoter.
Sitwala KV, Adams K, Markovitz DM
Oncogene. 2002
PubMed ID: 12483538
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes.
Krithivas A, Fujimuro M, Weidner M, Young DB, Hayward SD
J Virol. 2002
PubMed ID: 12388720
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Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
Hollenbach AD, McPherson CJ, Mientjes EJ, Iyengar R, Grosveld G
J Cell Sci. 2002
PubMed ID: 12140263
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The ubiquitous chromatin protein DEK alters the structure of DNA by introducing positive supercoils.
Waldmann T, Eckerich C, Baack M, Gruss C
J Biol Chem. 2002
PubMed ID: 11997399
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Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.
Larramendy ML, Niini T, Elonen E, Nagy B, Ollila J, Vihinen M, Knuutila S
Haematologica. 2002
PubMed ID: 12031912
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Gene expression in the developing mouse retina by EST sequencing and microarray analysis.
Mu X, Zhao S, Pershad R, Hsieh TF, Scarpa A, Wang SW, White RA, Beremand PD, Thomas TL, Gan L, Klein WH
Nucleic Acids Res. 2001
PubMed ID: 11812828
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Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.
Lykke-Andersen J, Shu MD, Steitz JA
Science. 2001
PubMed ID: 11546874
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Subcellular localization of the human proto-oncogene protein DEK.
Kappes F, Burger K, Baack M, Fackelmayer FO, Gruss C
J Biol Chem. 2001
PubMed ID: 11333257
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.
Le Hir H, Izaurralde E, Maquat LE, Moore MJ
EMBO J. 2000
PubMed ID: 11118221
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Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs.
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Int J Cancer. 2000
PubMed ID: 11058868
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
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Genome Res. 2000
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
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Genome Res. 2000
PubMed ID: 11042159
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The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes.
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J Cell Biol. 2000
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The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner.
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Genes Dev. 2000
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A method to identify cDNAs based on localization of green fluorescent protein fusion products.
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Proc Natl Acad Sci U S A. 2000
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Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells.
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J Biol Chem. 1999
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Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus.
Wichmann I, Garcia-Lozano JR, Respaldiza N, Gonzalez-Escribano MF, Nuñez-Roldan A
Hum Immunol. 1999
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
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Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis.
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Arthritis Rheum. 1998
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Juvenile arthritis, HLA-A2 and binding of DEK oncogene-peptides.
Forero L, Zwirner NW, Fink CW, Fernández-Viña MA, Stastny P
Hum Immunol. 1998
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DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer.
Fu GK, Grosveld G, Markovitz DM
Proc Natl Acad Sci U S A. 1997
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Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular onset juvenile rheumatoid arthritis and iridocyclitis: selective association with MHC gene.
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J Rheumatol. 1997
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Cloning, RNA expression, and chromosomal location of a mouse histamine H2 receptor gene.
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Genomics. 1996
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Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein.
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J Biol Chem. 1996
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Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.
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Mapping of murine fibroblast growth factor receptors refines regions of homology between mouse and human chromosomes.
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Science. 1993
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Translocation t(6;9) in acute non-lymphocytic leukaemia results in the formation of a DEK-CAN fusion gene.
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Baillieres Clin Haematol. 1992
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The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.
von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A, Grosveld G
Mol Cell Biol. 1992
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