Home CACNA1B
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(Human) GRCh37 - chr9:140772241..141019076 (246.84 kb) View in Genome Browser
(Mouse) NCBIM37 - chr2:24459407..24618672 (159.26 kb) View in Genome Browser
(Rat) RGSC3.4 - chr3:2842948..3039747 (196.80 kb) View in Genome Browser
HaemAtlas Expression Table for CACNA1B:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for CACNA1B:The CACNA1B interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| CACNA1B | CACNG2 | Reactome | predicted | |
| CACNA1B | PDLIM5 | HPRD, BioGRID | empirical | 12665800 |
| CACNA1B | RIMS1 | HPRD, IntAct | empirical | 11438518 21241895 |
| CACNA1B | RIMBP2 | IntAct | empirical | 21241895 |
| CACNA1B | GNAO1 | HPRD, BioGRID | empirical | 11395521 |
| CACNA1B | GNB1 | HPRD | empirical | 15953418 |
| CACNA1B | APBA1 | HPRD, MINT | empirical | 12177192 10455105 16007100 |
| CACNA1B | PPM1A | HPRD | empirical | 15728831 |
| CACNA1B | RGS12 | HPRD, MINT | empirical | 11130074 |
| CACNA1B | RXRB | IntAct | empirical | 20195357 |
| CACNA1B | SYT1 | IntAct | empirical | 9830048 |
| CACNA1B | SYT4 | IntAct | empirical | 9830048 |
| CACNA1B | UBC | BioGRID | empirical | 21906983 |
| CACNA1B | YWHAB | IntAct | empirical | 16635246 |
| CACNA1B | CACNA1B | HPRD | empirical | 15953418 |
| CACNA1B | CACNB3 | HPRD, Reactome | empirical | 12161429 |
| CACNA1B | SYT3 | IntAct | empirical | 9830048 |
| CACNA1B | CASK | MINT | empirical | 10455105 |
| CACNA1B | MRFAP1 | IntAct | empirical | 17353931 |
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Type 1 Diabetes Publications: 1
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Increased glucose tolerance in N-type Ca2+ channel alpha(1B)-subunit gene-deficient mice.
Takahashi E, Ito M, Miyamoto N, Nagasu T, Ino M, Tanaka I
Int J Mol Med. 2005
PubMed ID: 15870896
Publications: 133
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Bipartite syntaxin 1A interactions mediate CaV2.2 calcium channel regulation.
Davies JN, Jarvis SE, Zamponi GW
Biochem Biophys Res Commun. 2011
PubMed ID: 21763275
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A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
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Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation.
Waithe D, Ferron L, Page KM, Chaggar K, Dolphin AC
J Biol Chem. 2011
PubMed ID: 21233207
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Non-additive potentiation of glutamate release by phorbol esters and metabotropic mGlu7 receptor in cerebrocortical nerve terminals.
Martín R, Bartolomé-Martín D, Torres M, Sánchez-Prieto J
J Neurochem. 2011
PubMed ID: 21143597
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Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.
Chen J, Billings SE, Nishimune H
J Neurosci. 2011
PubMed ID: 21228161
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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The haplotype of the CACNA1B gene associated with cerebral infarction in a Japanese population.
Yamaguchi M, Nakayama T, Fu Z, Sato N, Soma M, Morita A, Hinohara S, Doba N, Mizutani T
Hereditas. 2010
PubMed ID: 21166801
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Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes.
Curtis D, Vine AE, McQuillin A, Bass NJ, Pereira A, Kandaswamy R, Lawrence J, Anjorin A, Choudhury K, Datta SR, Puri V, Krasucki R, Pimm J, Thirumalai S, Quested D, Gurling HM
Psychiatr Genet. 2010
PubMed ID: 21057379
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Opioid inhibition of N-type Ca2+ channels and spinal analgesia couple to alternative splicing.
Andrade A, Denome S, Jiang YQ, Marangoudakis S, Lipscombe D
Nat Neurosci. 2010
PubMed ID: 20852623
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Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
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G-proteins modulate invertebrate synaptic calcium channel (LCa(v)2) differently from the classical voltage-dependent regulation of mammalian Ca(v)2.1 and Ca(v)2.2 channels.
Huang X, Senatore A, Dawson TF, Quan Q, Spafford JD
J Exp Biol. 2010
PubMed ID: 20511524
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Strong synaptic transmission impact by copy number variations in schizophrenia.
Glessner JT, Reilly MP, Kim CE, Takahashi N, Albano A, Hou C, Bradfield JP, Zhang H, Sleiman PM, Flory JH, Imielinski M, Frackelton EC, Chiavacci R, Thomas KA, Garris M, Otieno FG, Davidson M, Weiser M, Reichenberg A, Davis KL, Friedman JI, Cappola TP, Margulies KB, Rader DJ, Grant SF, Buxbaum JD, Gur RE, Hakonarson H
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20489179
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Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.
Schlick B, Flucher BE, Obermair GJ
Neuroscience. 2010
PubMed ID: 20188150
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Behavioral and neurochemical characterization of mice deficient in the N-type Ca2+ channel alpha1B subunit.
Nakagawasai O, Onogi H, Mitazaki S, Sato A, Watanabe K, Saito H, Murai S, Nakaya K, Murakami M, Takahashi E, Tan-No K, Tadano T
Behav Brain Res. 2010
PubMed ID: 19963013
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Scanning mutagenesis of the I-II loop of the Cav2.2 calcium channel identifies residues Arginine 376 and Valine 416 as molecular determinants of voltage dependent G protein inhibition.
Tedford HW, Kisilevsky AE, Vieira LB, Varela D, Chen L, Zamponi GW
Mol Brain. 2010
PubMed ID: 20181083
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An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels.
Brittain JM, Piekarz AD, Wang Y, Kondo T, Cummins TR, Khanna R
J Biol Chem. 2009
PubMed ID: 19755421
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P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.
Fischer M, Pereira PM, Holtmann B, Simon CM, Hanauer A, Heisenberg M, Sendtner M
Mol Cell Neurosci. 2009
PubMed ID: 19555761
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Alternative splicing in the synaptic protein interaction site of rat Ca(v)2.2 (alpha (1B)) calcium channels: changes induced by chronic inflammatory pain.
Asadi S, Javan M, Ahmadiani A, Sanati MH
J Mol Neurosci. 2009
PubMed ID: 19125229
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Tumour necrosis factor alpha activates nuclear factor kappaB signalling to reduce N-type voltage-gated Ca2+ current in postganglionic sympathetic neurons.
Motagally MA, Lukewich MK, Chisholm SP, Neshat S, Lomax AE
J Physiol. 2009
PubMed ID: 19403618
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Gating charges per channel of Ca(V)2.2 channels are modified by G protein activation in rat sympathetic neurons.
Rebolledo-Antúnez S, Farías JM, Arenas I, García DE
Arch Biochem Biophys. 2009
PubMed ID: 19364492
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Inhibition of sympathetic N-type voltage-gated Ca2+ current underlies the reduction in norepinephrine release during colitis.
Motagally MA, Neshat S, Lomax AE
Am J Physiol Gastrointest Liver Physiol. 2009
PubMed ID: 19264956
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Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse.
Sehic A, Khuu C, Risnes S, Osmundsen H
Eur J Oral Sci. 2009
PubMed ID: 19320717
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Partial compensation for N-type Ca(2+) channel loss by P/Q-type Ca(2+) channels underlines the differential release properties supported by these channels at cerebrocortical nerve terminals.
Ladera C, Martín R, Bartolomé-Martín D, Torres M, Sánchez-Prieto J
Eur J Neurosci. 2009
PubMed ID: 19302149
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Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.
Moskvina V, Craddock N, Holmans P, Nikolov I, Pahwa JS, Green E, Wellcome Trust Case Control Consortium, Owen MJ, O'Donovan MC
Mol Psychiatry. 2009
PubMed ID: 19065143
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Deletion of N-type Ca(2+) channel Ca(v)2.2 results in hyperaggressive behaviors in mice.
Kim C, Jeon D, Kim YH, Lee CJ, Kim H, Shin HS
J Biol Chem. 2009
PubMed ID: 19004821
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A blocker of N- and T-type voltage-gated calcium channels attenuates ethanol-induced intoxication, place preference, self-administration, and reinstatement.
Newton PM, Zeng L, Wang V, Connolly J, Wallace MJ, Kim C, Shin HS, Belardetti F, Snutch TP, Messing RO
J Neurosci. 2008
PubMed ID: 18987207
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The role of MAP1A light chain 2 in synaptic surface retention of Cav2.2 channels in hippocampal neurons.
Leenders AG, Lin L, Huang LD, Gerwin C, Lu PH, Sheng ZH
J Neurosci. 2008
PubMed ID: 18971475
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Modified sympathetic nerve system activity with overexpression of the voltage-dependent calcium channel beta3 subunit.
Murakami M, Ohba T, Xu F, Satoh E, Miyoshi I, Suzuki T, Takahashi Y, Takahashi E, Watanabe H, Ono K, Sasano H, Kasai N, Ito H, Iijima T
J Biol Chem. 2008
PubMed ID: 18628210
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GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
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Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity.
Vitko I, Shcheglovitov A, Baumgart JP, Arias-Olguín II, Murbartián J, Arias JM, Perez-Reyes E
PLoS ONE. 2008
PubMed ID: 18958281
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Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.
Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y
Anal Sci. 2008
PubMed ID: 18187866
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The transmitter release-site CaV2.2 channel cluster is linked to an endocytosis coat protein complex.
Khanna R, Li Q, Schlichter LC, Stanley EF
Eur J Neurosci. 2007
PubMed ID: 17686037
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The presynaptic CaV2.2 channel-transmitter release site core complex.
Khanna R, Li Q, Bewersdorf J, Stanley EF
Eur J Neurosci. 2007
PubMed ID: 17686036
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Molecular heterogeneity of developing retinal ganglion and amacrine cells revealed through single cell gene expression profiling.
Trimarchi JM, Stadler MB, Roska B, Billings N, Sun B, Bartch B, Cepko CL
J Comp Neurol. 2007
PubMed ID: 17444492
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Differential role of N-type calcium channel splice isoforms in pain.
Altier C, Dale CS, Kisilevsky AE, Chapman K, Castiglioni AJ, Matthews EA, Evans RM, Dickenson AH, Lipscombe D, Vergnolle N, Zamponi GW
J Neurosci. 2007
PubMed ID: 17567797
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Impaired long-term memory and long-term potentiation in N-type Ca2+ channel-deficient mice.
Jeon D, Kim C, Yang YM, Rhim H, Yim E, Oh U, Shin HS
Genes Brain Behav. 2007
PubMed ID: 16939638
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A proteomic screen for presynaptic terminal N-type calcium channel (CaV2.2) binding partners.
Khanna R, Zougman A, Stanley EF
J Biochem Mol Biol. 2007
PubMed ID: 17562281
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Prospective isolation and global gene expression analysis of definitive and visceral endoderm.
Sherwood RI, Jitianu C, Cleaver O, Shaywitz DA, Lamenzo JO, Chen AE, Golub TR, Melton DA
Dev Biol. 2007
PubMed ID: 17328885
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Modified sympathetic regulation in N-type calcium channel null-mouse.
Murakami M, Ohba T, Wu TW, Fujisawa S, Suzuki T, Takahashi Y, Takahashi E, Watanabe H, Miyoshi I, Ono K, Sasano H, Ito H, Iijima T
Biochem Biophys Res Commun. 2007
PubMed ID: 17275790
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Alternative splicing controls G protein-dependent inhibition of N-type calcium channels in nociceptors.
Raingo J, Castiglioni AJ, Lipscombe D
Nat Neurosci. 2007
PubMed ID: 17293861
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Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.
Harrell MD, Harbi S, Hoffman JF, Zavadil J, Coetzee WA
Physiol Genomics. 2007
PubMed ID: 16985003
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Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM
Mol Cell Proteomics. 2007
PubMed ID: 17114649
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Munc18: a presynaptic transmitter release site N type (CaV2.2) calcium channel interacting protein.
Chan AW, Khanna R, Li Q, Stanley EF
Channels (Austin). 2007
PubMed ID: 19170253
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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
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BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling.
Berkefeld H, Sailer CA, Bildl W, Rohde V, Thumfart JO, Eble S, Klugbauer N, Reisinger E, Bischofberger J, Oliver D, Knaus HG, Schulte U, Fakler B
Science. 2006
PubMed ID: 17068255
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Alternative splicing in the C-terminus of CaV2.2 controls expression and gating of N-type calcium channels.
Castiglioni AJ, Raingo J, Lipscombe D
J Physiol. 2006
PubMed ID: 16857708
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Ethanol withdrawal is accompanied by downregulation of calcium channel alpha 1B subunit in rat inferior colliculus neurons.
N'Gouemo P, Yasuda RP, Morad M
Brain Res. 2006
PubMed ID: 16860782
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Ca2+ enhances U-type inactivation of N-type (CaV2.2) calcium current in rat sympathetic neurons.
Goo YS, Lim W, Elmslie KS
J Neurophysiol. 2006
PubMed ID: 16760341
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Blocker-resistant presynaptic voltage-dependent Ca2+ channels underlying glutamate release in mice nucleus tractus solitarii.
Yamazaki K, Shigetomi E, Ikeda R, Nishida M, Kiyonaka S, Mori Y, Kato F
Brain Res. 2006
PubMed ID: 16814754
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Role of the synprint site in presynaptic targeting of the calcium channel CaV2.2 in hippocampal neurons.
Szabo Z, Obermair GJ, Cooper CB, Zamponi GW, Flucher BE
Eur J Neurosci. 2006
PubMed ID: 16930401
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Inhibitory role of Ser-425 of the alpha1 2.2 subunit in the enhancement of Cav 2.2 currents by phorbol-12-myristate, 13-acetate.
Fang H, Patanavanich S, Rajagopal S, Yi X, Gill MS, Sando JJ, Kamatchi GL
J Biol Chem. 2006
PubMed ID: 16704976
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Differential distribution of voltage-gated calcium channels in dopaminergic neurons of the rat retina.
Witkovsky P, Shen C, McRory J
J Comp Neurol. 2006
PubMed ID: 16736476
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The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel function.
Butcher AJ, Leroy J, Richards MW, Pratt WS, Dolphin AC
J Physiol. 2006
PubMed ID: 16627564
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Enhanced expression of Ca2+ channel alpha1A and beta4 subunits and phosphorylated tyrosine hydroxylase in the adrenal gland of N-type Ca2+ channel alpha1B subunit-deficient mice with a CBA/JN genetic background.
Takahashi E, Nagasu T
Comp Med. 2006
PubMed ID: 16774125
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Comprehensive identification of phosphorylation sites in postsynaptic density preparations.
Trinidad JC, Specht CG, Thalhammer A, Schoepfer R, Burlingame AL
Mol Cell Proteomics. 2006
PubMed ID: 16452087
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Phoneutria nigriventer omega-Phonetoxin IIA: a new tool for anti-calcium channel autoantibody assays in Lambert-Eaton myasthenic syndrome.
Martin-Moutot N, Haro L, Santos RG, Mori Y, Seagar M
Neurobiol Dis. 2006
PubMed ID: 16289869
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Decreases in pheromonal responses at the accessory olfactory bulb of mice with a deficiency of the alpha1B or beta3 subunits of voltage-dependent Ca2+-channels.
Murakami M, Matsui H, Shiraiwa T, Suzuki T, Sasano H, Takahashi E, Kashiwayanagi M
Biol Pharm Bull. 2006
PubMed ID: 16508141
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International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.
Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J
Pharmacol Rev. 2005
PubMed ID: 16382099
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties.
Leroy J, Richards MW, Richards MS, Butcher AJ, Nieto-Rostro M, Pratt WS, Davies A, Dolphin AC
J Neurosci. 2005
PubMed ID: 16049174
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Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse.
Toba Y, Pakiam JG, Wray S
Eur J Neurosci. 2005
PubMed ID: 16029198
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G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.
Agler HL, Evans J, Tay LH, Anderson MJ, Colecraft HM, Yue DT
Neuron. 2005
PubMed ID: 15953418
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A tctex1-Ca2+ channel complex for selective surface expression of Ca2+ channels in neurons.
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Nat Neurosci. 2005
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A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.
Li D, Wang F, Lai M, Chen Y, Zhang JF
J Neurosci. 2005
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Testosterone modulates Ca(v2.2) calcium channels' functional expression at rat levator ani neuromuscular junction.
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Neuroscience. 2005
PubMed ID: 15987667
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Pattern of compensatory expression of voltage-dependent Ca2+ channel alpha1 and beta subunits in brain of N-type Ca2+ channel alpha1B subunit gene-deficient mice with a CBA/JN genetic background.
Takahashi E, Nagasu T
Exp Anim. 2005
PubMed ID: 15725679
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Mechanism of SNARE protein binding and regulation of Cav2 channels by phosphorylation of the synaptic protein interaction site.
Yokoyama CT, Myers SJ, Fu J, Mockus SM, Scheuer T, Catterall WA
Mol Cell Neurosci. 2005
PubMed ID: 15607937
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Effect of genetic background on Cav2 channel alpha1 and beta subunit messenger RNA expression in cerebellum of N-type Ca2+ channel alpha1B subunit-deficient mice.
Takahashi E, Ino M, Nagasu T
Comp Med. 2004
PubMed ID: 15679268
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Blocking the R-type (Cav2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance.
Yokoyama K, Kurihara T, Saegusa H, Zong S, Makita K, Tanabe T
Eur J Neurosci. 2004
PubMed ID: 15610184
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Deletion of N-type calcium channels alters ethanol reward and reduces ethanol consumption in mice.
Newton PM, Orr CJ, Wallace MJ, Kim C, Shin HS, Messing RO
J Neurosci. 2004
PubMed ID: 15525770
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Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.
Murakami M, Nakagawasai O, Suzuki T, Mobarakeh II, Sakurada Y, Murata A, Yamadera F, Miyoshi I, Yanai K, Tan-No K, Sasano H, Tadano T, Iijima T
Brain Res. 2004
PubMed ID: 15451373
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Deletion of the synaptic protein interaction site of the N-type (CaV2.2) calcium channel inhibits secretion in mouse pheochromocytoma cells.
Harkins AB, Cahill AL, Powers JF, Tischler AS, Fox AP
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15471993
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The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels.
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J Biol Chem. 2004
PubMed ID: 15166237
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DNA sequence and analysis of human chromosome 9.
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Nature. 2004
PubMed ID: 15164053
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Increased expression of P/Q-type Ca2+ channel alpha1A subunit mRNA in cerebellum of N-type Ca2+ channel alpha1B subunit gene-deficient mice.
Takahashi E, Ino M, Miyamoto N, Nagasu T
Brain Res Mol Brain Res. 2004
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Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.
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Neurosci Lett. 2004
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
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Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit.
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J Biol Chem. 2004
PubMed ID: 14602720
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Cell-specific alternative splicing increases calcium channel current density in the pain pathway.
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Neuron. 2004
PubMed ID: 14715140
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Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.
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Science. 2003
PubMed ID: 14684825
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Increased sensitivity to halothane but decreased sensitivity to propofol in mice lacking the N-type Ca2+ channel.
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Neurosci Lett. 2003
PubMed ID: 12962913
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N-type calcium channel alpha1B subunit (Cav2.2) knock-out mice display hyperactivity and vigilance state differences.
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J Neurosci. 2003
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Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.
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Nature. 2003
PubMed ID: 12827191
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A PKC epsilon-ENH-channel complex specifically modulates N-type Ca2+ channels.
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Nat Neurosci. 2003
PubMed ID: 12665800
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Latour I, Hamid J, Beedle AM, Zamponi GW, Macvicar BA
Glia. 2003
PubMed ID: 12555202
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Voltage-gated calcium channels in adult rat inferior colliculus neurons.
N'Gouemo P, Morad M
Neuroscience. 2003
PubMed ID: 12895521
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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Nature. 2002
PubMed ID: 12466851
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Characteristics of block by Pb2+ of function of human neuronal L-, N-, and R-type Ca2+ channels transiently expressed in human embryonic kidney 293 cells.
Peng S, Hajela RK, Atchison WD
Mol Pharmacol. 2002
PubMed ID: 12435810
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Mechanosensitivity of N-type calcium channel currents.
Calabrese B, Tabarean IV, Juranka P, Morris CE
Biophys J. 2002
PubMed ID: 12414690
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Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels.
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J Biol Chem. 2002
PubMed ID: 12161429
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Synaptic targeting of N-type calcium channels in hippocampal neurons.
Maximov A, Bezprozvanny I
J Neurosci. 2002
PubMed ID: 12177192
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Effects of ablation of N- and R-type Ca(2+) channels on pain transmission.
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Neurosci Res. 2002
PubMed ID: 12074836
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A direct repeat of N-type Ca2+ channel alpha1B gene functions as a negative regulatory element in HeLa cells.
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Mol Cells. 2002
PubMed ID: 12018859
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Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin.
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J Biol Chem. 2001
PubMed ID: 11438518
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Differential nociceptive responses in mice lacking the alpha(1B) subunit of N-type Ca(2+) channels.
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PubMed ID: 11496122
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PubMed ID: 11395521
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Altered nociceptive response in mice deficient in the alpha(1B) subunit of the voltage-dependent calcium channel.
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Mol Cell Neurosci. 2001
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Mouse histamine N-methyltransferase: cDNA cloning, expression, gene cloning and chromosomal localization.
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Inflamm Res. 2001
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Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis.
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PubMed ID: 11353727
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Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel.
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EMBO J. 2001
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Nature. 2001
PubMed ID: 11217851
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Biederer T, Südhof TC
J Biol Chem. 2000
PubMed ID: 11036064
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Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel.
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Nature. 2000
PubMed ID: 11130074
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
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Genome Res. 2000
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Alternative splicing in the cytoplasmic II-III loop of the N-type Ca channel alpha 1B subunit: functional differences are beta subunit-specific.
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J Neurosci. 2000
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Coexpression of cloned alpha(1B), beta(2a), and alpha(2)/delta subunits produces non-inactivating calcium currents similar to those found in bovine chromaffin cells.
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Alternative splicing of a short cassette exon in alpha1B generates functionally distinct N-type calcium channels in central and peripheral neurons.
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Mol Cell Neurosci. 1999
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Mamm Genome. 1999
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Genes Dev. 1996
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Genomics. 1995
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Genomics. 1995
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Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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Nature. 1994
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Science. 1992
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Proc Natl Acad Sci U S A. 1992
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