U2AF1

Summary Top Help

Gene Description:

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1; similar to Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 snRNP auxiliary factor small subunit); U2 small nuclear RNA auxiliary factor 1

Synonyms:

RN, 35kDa, U2AFBP, U2af1, 2010107D16Rik, LOC687575, U2AF35, U2AF1, RNU2AF1, FP793

Orthologs:

Human U2AF1 (protein-coding), Mouse U2af1 (protein-coding), Rat LOC687575 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr21:44513066..44527697 (14.63 kb) View in Genome Browser

(Mouse) NCBIM37 - chr17:31784027..31795699 (11.67 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for U2AF1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
								no data	no data	no data	no data	no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for U2AF1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 2

Biocarta: 1

Reactome: 16

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 21

KEGG Network: 2
Shigellosis	Human - 5131
Spliceosome	Human - 3040	Mouse - 3040	Rat - 3040

Biocarta: 1
Spliceosomal Assembly	Human

Reactome: 16
Cleavage of Growing Transcript in the Termination Region	REACT_387
Formation and Maturation of mRNA Transcript	REACT_2039
Gene Expression	REACT_71
mRNA 3-end processing	REACT_1849
mRNA Processing	REACT_1675
mRNA Splicing	REACT_1735
mRNA Splicing - Major Pathway	REACT_467
Post-Elongation Processing of Intron-Containing pre-mRNA	REACT_397
Post-Elongation Processing of the Transcript	REACT_78
Processing of Capped Intron-Containing Pre-mRNA	REACT_125
Processing of Capped Transcripts	REACT_1021
RNA Polymerase II Transcription	REACT_1366
RNA Polymerase II Transcription Termination	REACT_894
Transcription	REACT_1788
Transport of Mature mRNA derived from an Intron-Containing Transcript	REACT_1597
Transport of Mature Transcript to Cytoplasm	REACT_1281

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 21
Nucleotide binding	GO:0000166
Nuclear mRNA splicing, via spliceosome	GO:0000398
RNA binding	GO:0003723
Protein binding	GO:0005515
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Spliceosomal complex	GO:0005681
Nucleolus	GO:0005730
Transcription from RNA polymerase II promoter	GO:0006366
Termination of RNA polymerase II transcription	GO:0006369
MRNA processing	GO:0006397
MRNA export from nucleus	GO:0006406
Zinc ion binding	GO:0008270
RNA splicing	GO:0008380
Gene expression	GO:0010467
Cajal body	GO:0015030
Nuclear speck	GO:0016607
MRNA 3'-end processing	GO:0031124
Metal ion binding	GO:0046872
RS domain binding	GO:0050733
Catalytic step 2 spliceosome	GO:0071013

Publications from PubMed Top Help

Publications: 87

Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs).
Lopitz-Otsoa F, Rodriguez-Suarez E, Aillet F, Casado-Vela J, Lang V, Matthiesen R, Elortza F, Rodriguez MS
J Proteomics. 2011
PubMed ID: 22178446
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Altun M, Kramer HB, Willems LI, McDermott JL, Leach CA, Goldenberg SJ, Kumar KG, Konietzny R, Fischer R, Kogan E, Mackeen MM, McGouran J, Khoronenkova SV, Parsons JL, Dianov GL, Nicholson B, Kessler BM
Chem Biol. 2011
PubMed ID: 22118674
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome.
Pereira PL, Magnol L, Sahún I, Brault V, Duchon A, Prandini P, Gruart A, Bizot JC, Chadefaux-Vekemans B, Deutsch S, Trovero F, Delgado-García JM, Antonarakis SE, Dierssen M, Herault Y
Hum Mol Genet. 2009
PubMed ID: 19783846
Variants of organic anion transporter polypeptide 2 gene are not risk factors associated with severe neonatal hyperbilirubinemia.
Wong FL, Boo NY, Ainoon O, Wang MK
Malays J Pathol. 2009
PubMed ID: 20514852
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Splicing factors SF1 and U2AF associate in extraspliceosomal complexes.
Rino J, Desterro JM, Pacheco TR, Gadella TW, Carmo-Fonseca M
Mol Cell Biol. 2008
PubMed ID: 18285458
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Splicing factor SPF30 bridges an interaction between the prespliceosome protein U2AF35 and tri-small nuclear ribonucleoprotein protein hPrp3.
Little JT, Jurica MS
J Biol Chem. 2008
PubMed ID: 18211889
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
PHF5A represents a bridge protein between splicing proteins and ATP-dependent helicases and is differentially expressed during mouse spermatogenesis.
Rzymski T, Grzmil P, Meinhardt A, Wolf S, Burfeind P
Cytogenet Genome Res. 2008
PubMed ID: 18758164
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing.
Miele A, Medina R, van Wijnen AJ, Stein GS, Stein JL
J Cell Biochem. 2007
PubMed ID: 17577209
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.
Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B
Mol Cell. 2007
PubMed ID: 17643375
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ
Science. 2007
PubMed ID: 17525332
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G, Martin P, Rogers J, Lawlor S, McLaren S, Dricot A, Borick H, Cusick ME, Vandenhaute J, Dunham I, Hill DE, Vidal M
Genomics. 2007
PubMed ID: 17207965
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
In vivo requirement of the small subunit of U2AF for recognition of a weak 3' splice site.
Pacheco TR, Coelho MB, Desterro JM, Mollet I, Carmo-Fonseca M
Mol Cell Biol. 2006
PubMed ID: 16940179
RNA interference knockdown of hU2AF35 impairs cell cycle progression and modulates alternative splicing of Cdc25 transcripts.
Pacheco TR, Moita LF, Gomes AQ, Hacohen N, Carmo-Fonseca M
Mol Biol Cell. 2006
PubMed ID: 16855028
Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
Wang AG, Yoon SY, Oh JH, Jeon YJ, Kim M, Kim JM, Byun SS, Yang JO, Kim JH, Kim DG, Yeom YI, Yoo HS, Kim YS, Kim NS
Biochem Biophys Res Commun. 2006
PubMed ID: 16712791
Intron removal requires proofreading of U2AF/3' splice site recognition by DEK.
Soares LM, Zanier K, Mackereth C, Sattler M, Valcárcel J
Science. 2006
PubMed ID: 16809543
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
Nuclear export factor family protein participates in cytoplasmic mRNA trafficking.
Tretyakova I, Zolotukhin AS, Tan W, Bear J, Propst F, Ruthel G, Felber BK
J Biol Chem. 2005
PubMed ID: 16014633
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
FRET analyses of the U2AF complex localize the U2AF35/U2AF65 interaction in vivo and reveal a novel self-interaction of U2AF35.
Chusainow J, Ajuh PM, Trinkle-Mulcahy L, Sleeman JE, Ellenberg J, Lamond AI
RNA. 2005
PubMed ID: 16043505
Shigella effector IpaH9.8 binds to a splicing factor U2AF(35) to modulate host immune responses.
Okuda J, Toyotome T, Kataoka N, Ohno M, Abe H, Shimura Y, Seyedarabi A, Pickersgill R, Sasakawa C
Biochem Biophys Res Commun. 2005
PubMed ID: 15950937
Substrate-dependent differences in U2AF requirement for splicing in adenovirus-infected cell extracts.
Lützelberger M, Backström E, Akusjärvi G
J Biol Chem. 2005
PubMed ID: 15899895
A novel SR-related protein is required for the second step of Pre-mRNA splicing.
Cazalla D, Newton K, Cáceres JF
Mol Cell Biol. 2005
PubMed ID: 15798186
CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing.
Maita H, Kitaura H, Ariga H, Iguchi-Ariga SM
Exp Cell Res. 2005
PubMed ID: 15652350
A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
McKee AE, Minet E, Stern C, Riahi S, Stiles CD, Silver PA
BMC Dev Biol. 2005
PubMed ID: 16033648
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor.
Maita H, Kitaura H, Keen TJ, Inglehearn CF, Ariga H, Iguchi-Ariga SM
Exp Cell Res. 2004
PubMed ID: 15474994
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Diversity of vertebrate splicing factor U2AF35: identification of alternatively spliced U2AF1 mRNAS.
Pacheco TR, Gomes AQ, Barbosa-Morais NL, Benes V, Ansorge W, Wollerton M, Smith CW, Valcárcel J, Carmo-Fonseca M
J Biol Chem. 2004
PubMed ID: 15096518
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.
Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R
RNA. 2004
PubMed ID: 15146077
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome.
Hayano T, Yanagida M, Yamauchi Y, Shinkawa T, Isobe T, Takahashi N
J Biol Chem. 2003
PubMed ID: 12777385
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
A gene expression map of human chromosome 21 orthologues in the mouse.
Gitton Y, Dahmane N, Baik S, Ruiz i Altaba A, Neidhardt L, Scholze M, Herrmann BG, Kahlem P, Benkahla A, Schrinner S, Yildirimman R, Herwig R, Lehrach H, Yaspo ML, HSA21 expression map initiative
Nature. 2002
PubMed ID: 12466855
Human chromosome 21 gene expression atlas in the mouse.
Reymond A, Marigo V, Yaylaoglu MB, Leoni A, Ucla C, Scamuffa N, Caccioppoli C, Dermitzakis ET, Lyle R, Banfi S, Eichele G, Antonarakis SE, Ballabio A
Nature. 2002
PubMed ID: 12466854
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Induced folding of the U2AF35 RRM upon binding to U2AF65.
Kellenberger E, Stier G, Sattler M
FEBS Lett. 2002
PubMed ID: 12297299
Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.
Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R
EMBO J. 2002
PubMed ID: 12234937
Comprehensive proteomic analysis of the human spliceosome.
Zhou Z, Licklider LJ, Gygi SP, Reed R
Nature. 2002
PubMed ID: 12226669
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD
Science. 2002
PubMed ID: 12040188
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ
RNA. 2002
PubMed ID: 11991638
U2AF participates in the binding of TAP (NXF1) to mRNA.
Zolotukhin AS, Tan W, Bear J, Smulevitch S, Felber BK
J Biol Chem. 2002
PubMed ID: 11724776
A misspliced form of the cholecystokinin-B/gastrin receptor in pancreatic carcinoma: role of reduced sellular U2AF35 and a suboptimal 3'-splicing site leading to retention of the fourth intron.
Ding WQ, Kuntz SM, Miller LJ
Cancer Res. 2002
PubMed ID: 11830556
Characterization of U2AF(6), a splicing factor related to U2AF(35).
Shepard J, Reick M, Olson S, Graveley BR
Mol Cell Biol. 2002
PubMed ID: 11739736
Evolutionary breakpoints on human chromosome 21.
Davisson MT, Bechtel LJ, Akeson EC, Fortna A, Slavov D, Gardiner K
Genomics. 2001
PubMed ID: 11707078
Dual function for U2AF(35) in AG-dependent pre-mRNA splicing.
Guth S, Tange TØ, Kellenberger E, Valcárcel J
Mol Cell Biol. 2001
PubMed ID: 11604503
Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation.
Nesic D, Krämer A
Mol Cell Biol. 2001
PubMed ID: 11533230
A novel peptide recognition mode revealed by the X-ray structure of a core U2AF35/U2AF65 heterodimer.
Kielkopf CL, Rodionova NA, Green MR, Burley SK
Cell. 2001
PubMed ID: 11551507
A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site.
Will CL, Schneider C, MacMillan AM, Katopodis NF, Neubauer G, Wilm M, Lührmann R, Query CC
EMBO J. 2001
PubMed ID: 11500380
ZNF265--a novel spliceosomal protein able to induce alternative splicing.
Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE
J Cell Biol. 2001
PubMed ID: 11448987
Nucleocytoplasmic shuttling of heterodimeric splicing factor U2AF.
Gama-Carvalho M, Carvalho MP, Kehlenbach A, Valcarcel J, Carmo-Fonseca M
J Biol Chem. 2001
PubMed ID: 11118443
The sequence of the human genome.
Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigó R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X
Science. 2001
PubMed ID: 11181995
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.
de Vries H, Rüegsegger U, Hübner W, Friedlein A, Langen H, Keller W
EMBO J. 2000
PubMed ID: 11060040
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
The DNA sequence of human chromosome 21.
Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML, Chromosome 21 mapping and sequencing consortium
Nature. 2000
PubMed ID: 10830953
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2.
Xiao SH, Manley JL
EMBO J. 1998
PubMed ID: 9799243
Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.
Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M
Nat Genet. 1998
PubMed ID: 9731529
SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements.
Nayler O, Strätling W, Bourquin JP, Stagljar I, Lindemann L, Jasper H, Hartmann AM, Fackelmayer FO, Ullrich A, Stamm S
Nucleic Acids Res. 1998
PubMed ID: 9671816
A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site.
Gozani O, Potashkin J, Reed R
Mol Cell Biol. 1998
PubMed ID: 9671485
Functional association of nuclear protein 4.1 with pre-mRNA splicing factors.
Lallena MJ, Martínez C, Valcárcel J, Correas I
J Cell Sci. 1998
PubMed ID: 9645944
Interaction between subunits of heterodimeric splicing factor U2AF is essential in vivo.
Rudner DZ, Kanaar R, Breger KS, Rio DC
Mol Cell Biol. 1998
PubMed ID: 9528748
SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells.
Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD
J Cell Biol. 1998
PubMed ID: 9472028
A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA.
Tronchère H, Wang J, Fu XD
Nature. 1997
PubMed ID: 9237760
Association of U2 snRNP with the spliceosomal complex E.
Hong W, Bennett M, Xiao Y, Feld Kramer R, Wang C, Reed R
Nucleic Acids Res. 1997
PubMed ID: 9016565
Functional properties of p54, a novel SR protein active in constitutive and alternative splicing.
Zhang WJ, Wu JY
Mol Cell Biol. 1996
PubMed ID: 8816452
The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing.
Zuo P, Maniatis T
Genes Dev. 1996
PubMed ID: 8647433
The gene for human U2 snRNP auxiliary factor small 35-kDa subunit (U2AF1) maps to the progressive myoclonus epilepsy (EPM1) critical region on chromosome 21q22.3.
Lalioti MD, Gos A, Green MR, Rossier C, Morris MA, Antonarakis SE
Genomics. 1996
PubMed ID: 8660980
Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5.
Kalcheva I, Plass C, Sait S, Eddy R, Shows T, Watkins-Chow D, Camper S, Shibata H, Ueda T, Takagi N
Cytogenet Cell Genet. 1995
PubMed ID: 7956352
Specific interactions between proteins implicated in splice site selection and regulated alternative splicing.
Wu JY, Maniatis T
Cell. 1993
PubMed ID: 8261509
Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit.
Zhang M, Zamore PD, Carmo-Fonseca M, Lamond AI, Green MR
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1388271
Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution.
Zamore PD, Green MR
EMBO J. 1991
PubMed ID: 1824937

Model Organism Phenotype Links from MGI Top Help

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	Human	Mouse	Rat
Entrez Gene	7307	108121	687575
EnsEMBL Gene(s)	ENSG00000160201	ENSMUSG00000061613	N/A
Unigene	Hs.365116	Mm.379289	Rn.216659
Homologene	U2AF1	U2af1	LOC687575
OMIM	191317	N/A	N/A
GeneCards	U2AF1	N/A	N/A
Beta Cell Genomics	DT.100814480 DT.446719 DT.446720 DT.65285770 DT.91770412 DT.97769413 DT.97859339 DT.97859340	DT.101235198 DT.532581	N/A
Reactome	Q01081	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	7307	108121	687575

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Interactor	Interactor	Sources	Classification	Pubmed IDs
U2AF1	RBM5	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
U2AF1	ALYREF	Reactome	predicted	12176931 11991638 12477934
U2AF1	HNRNPR	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	SRRM1	Reactome	predicted	12176931 11991638 12477934
U2AF1	CD2BP2	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
U2AF1	NXF1	HPRD, BioGRID	empirical	11724776
U2AF1	NOP56	BioGRID	empirical	12777385
U2AF1	PAPOLA	Reactome	predicted
U2AF1	RNPS1	IntAct	empirical	17353931
U2AF1	SF3A3	HPRD	empirical	11533230
U2AF1	HNRNPA0	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	HNRNPUL1	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
U2AF1	GABARAP	IntAct	empirical	20562859
U2AF1	U2AF2	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	1388271 11551507 16189514 21988832 12176931 11991638 12477934 6088074 6206566
U2AF1	GABARAPL2	IntAct	empirical	20562859
U2AF1	DHX9	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
U2AF1	EPB41	HPRD	empirical	9645944
U2AF1	HNRNPA3	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	DNAJC8	Reactome	predicted	12176931 11991638 6088074 6206566
U2AF1	SRRM2	Sanger Interaction Map	predicted	15345047
U2AF1	FUS	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
U2AF1	RNU11	BioGRID	empirical	15146077
U2AF1	RBMX	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	HDGF	IntAct	empirical	21907836
U2AF1	HNRNPA1	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	HNRNPA2B1	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	HNRNPC	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	HNRNPD	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	HNRNPF	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	HNRNPH1	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	HNRNPH2	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	HNRNPK	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	HNRNPL	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	HNRNPU	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	MAP1B	HPRD	empirical	16014633
U2AF1	HNRNPM	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	NFX1	Reactome	predicted	12176931 11991638 12477934
U2AF1	YBX1	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
U2AF1	PCBP1	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	PCBP2	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	CDC40	Reactome	predicted	12176931 11991638 6088074 6206566
U2AF1	CCAR1	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
U2AF1	MEPCE	BioGRID	empirical	17643375
U2AF1	PTBP1	Reactome	predicted	12176931 12477934 6088074 6206566
U2AF1	SUGP1	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
U2AF1	RP9	HPRD, BioGRID	empirical	15474994
U2AF1	SAFB	BioGRID	empirical	9671816
U2AF1	SRSF1	HPRD, IntAct, BioGRID, Reactome	empirical	9799243 8261509 21988832 8816452 12176931 11991638 12477934 6088074 6206566
U2AF1	SRSF2	HPRD, BioGRID, Reactome	empirical	8261509 8816452 12176931 11991638 12477934 6088074 6206566
U2AF1	SRSF3	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
U2AF1	SRSF4	Reactome	predicted	12176931 11991638 6088074 6206566
U2AF1	SRSF5	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
U2AF1	SRSF6	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
U2AF1	SRSF7	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
U2AF1	SRPK1	HPRD	empirical	9472028
U2AF1	UBC	BioGRID	empirical	22178446 22118674 21139048 21890473
U2AF1	VEGFA	IntAct	empirical	21988832
U2AF1	PABPN1	Reactome	predicted
U2AF1	SF3A2	MINT, BioGRID	empirical	17332742 12234937
U2AF1	ZRSR2	HPRD	empirical	9237760
U2AF1	SMC1A	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
U2AF1	SRSF9	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
U2AF1	SRSF11	Reactome	predicted	12176931 11991638 6088074 6206566
U2AF1	ZRANB2	HPRD, BioGRID	empirical	11448987
U2AF1	CIR1	IntAct	empirical	15652350
U2AF1	KIAA0101	BioGRID	empirical	21628590
U2AF1	DHX38	Reactome	predicted	12176931 11991638 6088074 6206566