TUBA4A
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Linkage Regions: 1 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes | Linkage and Congenic Studies |
|---|---|---|---|---|---|
| Idd5.2 | Mouse | chr1:73984129..75465013 | 1.48 | 52 | 3 no lod score |
(Human) GRCh37 - chr2:220114433..220142892 (28.46 kb) View in Genome Browser
(Mouse) NCBIM37 - chr1:75211549..75215828 (4.28 kb) View in Genome Browser
(Rat) RGSC3.4 - chr9:74496508..74500192 (3.68 kb) View in Genome Browser
HaemAtlas Expression Table for TUBA4A:
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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Expression Legend
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for TUBA4A:The TUBA4A interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| TUBA4A | HDAC6 | HPRD, MINT | empirical | 12024216 |
| TUBA4A | ACTR1A | Reactome | predicted | 12852856 |
| TUBA4A | AKAP9 | Reactome | predicted | 12852856 |
| TUBA4A | GPHN | HPRD | empirical | 1657993 |
| TUBA4A | TUBB4A | Reactome | predicted | 12852856 |
| TUBA4A | TUBB4B | Reactome | predicted | 12852856 |
| TUBA4A | DCTN2 | Reactome | predicted | 12852856 |
| TUBA4A | CCT7 | Reactome | predicted | |
| TUBA4A | CCT4 | Reactome | predicted | |
| TUBA4A | CCT2 | Reactome | predicted | |
| TUBA4A | CETN2 | Reactome | predicted | 12852856 |
| TUBA4A | CCT8 | Reactome | predicted | |
| TUBA4A | PLK4 | Reactome | predicted | 12852856 |
| TUBA4A | SDCCAG8 | Reactome | predicted | 12852856 |
| TUBA4A | HSPH1 | HPRD | empirical | 12749852 |
| TUBA4A | CNTRL | Reactome | predicted | 12852856 |
| TUBA4A | FGFR1OP | Reactome | predicted | 12852856 |
| TUBA4A | CEP250 | Reactome | predicted | 12852856 |
| TUBA4A | DCTN3 | Reactome | predicted | 12852856 |
| TUBA4A | GABARAP | IntAct | empirical | 20562859 |
| TUBA4A | GABARAPL2 | IntAct | empirical | 20562859 |
| TUBA4A | TBCB | HPRD | empirical | 9265649 |
| TUBA4A | NEDD1 | Reactome | predicted | 12852856 |
| TUBA4A | CSNK1D | Reactome | predicted | 12852856 |
| TUBA4A | CSNK1E | Reactome | predicted | 12852856 |
| TUBA4A | DCTN1 | Reactome | predicted | 12852856 |
| TUBA4A | DLG4 | IntAct | empirical | 19022416 |
| TUBA4A | DYNC1H1 | Reactome | predicted | 12852856 |
| TUBA4A | DYNC1I2 | Reactome | predicted | 12852856 |
| TUBA4A | E2F1 | IntAct | empirical | 20195357 |
| TUBA4A | EGFR | HPRD, IntAct | empirical | 16799092 |
| TUBA4A | ENO2 | HPRD, MINT, IntAct, BioGRID | empirical | 16169070 |
| TUBA4A | EPB41 | HPRD | empirical | 15184364 |
| TUBA4A | SKA1 | MINT | empirical | 17093495 |
| TUBA4A | CEP164 | Reactome | predicted | 12852856 |
| TUBA4A | MAPRE1 | Reactome | predicted | 12852856 |
| TUBA4A | SIRT2 | HPRD | empirical | 12620231 |
| TUBA4A | CCT5 | Reactome | predicted | |
| TUBA4A | NINL | Reactome | predicted | 12852856 |
| TUBA4A | AZI1 | Reactome | predicted | 12852856 |
| TUBA4A | CEP152 | Reactome | predicted | 12852856 |
| TUBA4A | NCOA6 | BioGRID | empirical | 12482968 |
| TUBA4A | RPGRIP1L | IntAct | empirical | 21565611 |
| TUBA4A | CLASP1 | Reactome | predicted | 12852856 |
| TUBA4A | SRRM2 | BioGRID | empirical | 16159877 |
| TUBA4A | GABARAPL1 | IntAct | empirical | 20562859 |
| TUBA4A | FYN | HPRD | empirical | 8566014 |
| TUBA4A | NPHP4 | IntAct | empirical | 21565611 |
| TUBA4A | B4GALT1 | HPRD | empirical | 7744867 |
| TUBA4A | GNAI2 | HPRD, IntAct | empirical | 16169070 |
| TUBA4A | GRB2 | IntAct | empirical | 12577067 |
| TUBA4A | GRIN1 | MINT | empirical | 10862698 |
| TUBA4A | RACGAP1 | HPRD | empirical | 11942621 |
| TUBA4A | GRM7 | HPRD | empirical | 11953448 |
| TUBA4A | APC | HPRD, BioGRID | empirical | 11166179 |
| TUBA4A | HSP90AA1 | Reactome | predicted | 12852856 |
| TUBA4A | C5orf25 | HPRD, MINT, IntAct | empirical | 16169070 |
| TUBA4A | KCNMA1 | IntAct | empirical | 19423573 |
| TUBA4A | ARHGAP1 | HPRD | empirical | 14697242 |
| TUBA4A | LGALS2 | HPRD | empirical | 15129282 |
| TUBA4A | LTA | HPRD | empirical | 15129282 |
| TUBA4A | TM4SF1 | HPRD, IntAct | empirical | 16169070 |
| TUBA4A | ARRB1 | IntAct | empirical | 17620599 |
| TUBA4A | SMAD1 | MINT | empirical | 17183365 |
| TUBA4A | SMAD2 | IntAct | empirical | 20195357 |
| TUBA4A | ARRB2 | IntAct | empirical | 17620599 |
| TUBA4A | MAP1A | HPRD | empirical | 9593747 11278895 |
| TUBA4A | MAPT | HPRD | empirical | 9922135 |
| TUBA4A | ASCL2 | BioGRID | empirical | 12482968 |
| TUBA4A | MYC | HPRD, IntAct, BioGRID | empirical | 7651436 17314511 21150319 |
| TUBA4A | NEK2 | Reactome | predicted | 12852856 |
| TUBA4A | ODF2 | Reactome | predicted | 12852856 |
| TUBA4A | PAFAH1B1 | Reactome | predicted | 12852856 |
| TUBA4A | PARK2 | HPRD | empirical | 12716939 |
| TUBA4A | PCM1 | Reactome | predicted | 12852856 |
| TUBA4A | PCNT | Reactome | predicted | 12852856 |
| TUBA4A | UCHL5 | BioGRID | empirical | 21800051 |
| TUBA4A | RAB8B | HPRD | empirical | 12639940 |
| TUBA4A | PFDN4 | HPRD | empirical | 14634002 |
| TUBA4A | PLK1 | HPRD, Reactome | empirical | 10191277 12852856 |
| TUBA4A | NDE1 | Reactome | predicted | 12852856 |
| TUBA4A | CEP192 | Reactome | predicted | 12852856 |
| TUBA4A | HAUS2 | Reactome | predicted | 12852856 |
| TUBA4A | RBM23 | HPRD, MINT, IntAct, BioGRID | empirical | 16169070 |
| TUBA4A | PPP2R1A | Reactome | predicted | 12852856 |
| TUBA4A | PPP2R2A | BioGRID | empirical | 19156129 |
| TUBA4A | PRKACA | Reactome | predicted | 12852856 |
| TUBA4A | CEP72 | Reactome | predicted | 12852856 |
| TUBA4A | CDK5RAP2 | Reactome | predicted | 12852856 |
| TUBA4A | PRKAR2B | Reactome | predicted | 12852856 |
| TUBA4A | CENPJ | Reactome | predicted | 12852856 |
| TUBA4A | MAPK3 | MINT | empirical | 19935650 |
| TUBA4A | RTN4 | HPRD | empirical | 12377379 |
| TUBA4A | MARK4 | HPRD | empirical | 14594945 |
| TUBA4A | RAC1 | HPRD | empirical | 8631991 |
| TUBA4A | RAD23B | IntAct | empirical | 20178748 |
| TUBA4A | RBBP5 | BioGRID | empirical | 12482968 |
| TUBA4A | RPL12 | IntAct | empirical | 16169070 |
| TUBA4A | CLIP1 | MINT | empirical | 16455083 16362039 |
| TUBA4A | S100A8 | HPRD, IntAct | empirical | 16169070 |
| TUBA4A | SHC1 | IntAct | empirical | 20697350 |
| TUBA4A | SIAH1 | HPRD | empirical | 11146551 |
| TUBA4A | SUMO3 | BioGRID | empirical | 22082260 |
| TUBA4A | SNCA | IntAct | empirical | 18614564 |
| TUBA4A | BRCA1 | HPRD | empirical | 12353262 |
| TUBA4A | STXBP1 | BioGRID | empirical | 12963086 |
| TUBA4A | SYK | HPRD | empirical | 8617742 |
| TUBA4A | TBCE | HPRD | empirical | 9265649 |
| TUBA4A | BTK | IntAct | empirical | 21080425 |
| TUBA4A | TCP1 | HPRD, Reactome | empirical | 9885248 |
| TUBA4A | CCT3 | Reactome | predicted | |
| TUBA4A | TUBG1 | Reactome | predicted | 12852856 |
| TUBA4A | UBC | BioGRID | empirical | 19850743 21987572 20972266 21139048 21890473 21906983 |
| TUBA4A | VAV1 | HPRD | empirical | 8530437 |
| TUBA4A | VDAC1 | HPRD | empirical | 12087096 |
| TUBA4A | VHL | BioGRID | empirical | 21942715 |
| TUBA4A | YWHAG | HPRD, Reactome | empirical | 15324660 12852856 |
| TUBA4A | ZAP70 | HPRD | empirical | 8530437 |
| TUBA4A | ALMS1 | Reactome | predicted | 12852856 |
| TUBA4A | TUBA1A | Reactome | predicted | 12852856 |
| TUBA4A | CALB2 | HPRD | empirical | 10942575 |
| TUBA4A | CEP76 | Reactome | predicted | 12852856 |
| TUBA4A | CEP290 | Reactome | predicted | 12852856 |
| TUBA4A | CEP63 | Reactome | predicted | 12852856 |
| TUBA4A | CEP70 | Reactome | predicted | 12852856 |
| TUBA4A | MAP1LC3B | IntAct | empirical | 20562859 |
| TUBA4A | NCALD | HPRD | empirical | 11964161 |
| TUBA4A | C4orf17 | HPRD, IntAct, BioGRID | empirical | 16169070 |
| TUBA4A | CEP78 | Reactome | predicted | 12852856 |
| TUBA4A | MAP1LC3A | HPRD, IntAct | empirical | 11278895 20562859 |
| TUBA4A | OFD1 | Reactome | predicted | 12852856 |
| TUBA4A | SSNA1 | Reactome | predicted | 12852856 |
| TUBA4A | DYNLL1 | Reactome | predicted | 12852856 |
| TUBA4A | ACTN2 | IntAct | empirical | 16169070 |
| TUBA4A | STARD13 | HPRD, IntAct | empirical | 14697242 |
| TUBA4A | CCT6A | Reactome | predicted | |
| TUBA4A | TAOK2 | HPRD | empirical | 12639963 |
| TUBA4A | MAGED1 | HPRD, IntAct | empirical | 16169070 |
| TUBA4A | BCAR1 | HPRD, IntAct | empirical | 16169070 |
| TUBA4A | CEP41 | Reactome | predicted | 12852856 |
| TUBA4A | IQCB1 | IntAct | empirical | 21565611 |
| TUBA4A | CEP135 | Reactome | predicted | 12852856 |
| TUBA4A | CEP57 | Reactome | predicted | 12852856 |
| TUBA4A | CCP110 | Reactome | predicted | 12852856 |
| TUBA4A | KIAA0101 | BioGRID | empirical | 21628590 |
| TUBA4A | CKAP5 | Reactome | predicted | 12852856 |
| TUBA4A | SFI1 | Reactome | predicted | 12852856 |
| TUBA4A | CDK1 | Reactome | predicted | 12852856 |
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Publications: 112
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Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics.
Yang W, Thompson JW, Wang Z, Wang L, Sheng H, Foster MW, Moseley MA, Paschen W
J Proteome Res. 2012
PubMed ID: 22082260
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The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.
Fang Y, Mu J, Ma Y, Ma D, Fu D, Shen X
Mol Cell Biochem. 2012
PubMed ID: 21800051
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Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
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Proteomic dissection of the von Hippel-Lindau (VHL) interactome.
Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y
J Proteome Res. 2011
PubMed ID: 21942715
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Postmortem proteomic analysis in human amygdala of drug addicts: possible impact of tubulin on drug-abusing behavior.
Zill P, Vielsmeier V, Büttner A, Eisenmenger W, Siedler F, Scheffer B, Möller HJ, Bondy B
Eur Arch Psychiatry Clin Neurosci. 2011
PubMed ID: 20686780
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Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA
PLoS One. 2011
PubMed ID: 21731673
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Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
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Dynamic subunit exchange and the regulation of microtubule assembly by the stress response protein human alphaB crystallin.
Houck SA, Clark JI
PLoS One. 2010
PubMed ID: 20668689
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The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
Zhao J, Li M, Bradfield JP, Zhang H, Mentch FD, Wang K, Sleiman PM, Kim CE, Glessner JT, Hou C, Keating BJ, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Chiavacci RM, Berkowitz RI, Hakonarson H, Grant SF
BMC Med Genet. 2010
PubMed ID: 20546612
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TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells.
Vanderwerf SM, Svahn J, Olson S, Rathbun RK, Harrington C, Yates J, Keeble W, Anderson DC, Anur P, Pereira NF, Pilonetto DV, Pasquini R, Bagby GC
Blood. 2009
PubMed ID: 19850743
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Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
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Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.
Rogowski K, Juge F, van Dijk J, Wloga D, Strub JM, Levilliers N, Thomas D, Bré MH, Van Dorsselaer A, Gaertig J, Janke C
Cell. 2009
PubMed ID: 19524510
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An integrated workflow for charting the human interaction proteome: insights into the PP2A system.
Glatter T, Wepf A, Aebersold R, Gstaiger M
Mol Syst Biol. 2009
PubMed ID: 19156129
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Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions.
McFarland MA, Ellis CE, Markey SP, Nussbaum RL
Mol Cell Proteomics. 2008
PubMed ID: 18614564
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Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
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A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
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Many sequence variants affecting diversity of adult human height.
Gudbjartsson DF, Walters GB, Thorleifsson G, Stefansson H, Halldorsson BV, Zusmanovich P, Sulem P, Thorlacius S, Gylfason A, Steinberg S, Helgadottir A, Ingason A, Steinthorsdottir V, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Borch-Johnsen K, Hansen T, Andersen G, Jorgensen T, Pedersen O, Aben KK, Witjes JA, Swinkels DW, den Heijer M, Franke B, Verbeek AL, Becker DM, Yanek LR, Becker LC, Tryggvadottir L, Rafnar T, Gulcher J, Kiemeney LA, Kong A, Thorsteinsdottir U, Stefansson K
Nat Genet. 2008
PubMed ID: 18391951
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Phosphoproteome of resting human platelets.
Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schütz C, Walter U, Gambaryan S, Sickmann A
J Proteome Res. 2008
PubMed ID: 18088087
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Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
Ballif BA, Carey GR, Sunyaev SR, Gygi SP
J Proteome Res. 2008
PubMed ID: 18034455
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Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD
J Proteome Res. 2007
PubMed ID: 17924679
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A revised nomenclature for the human and rodent alpha-tubulin gene family.
Khodiyar VK, Maltais LJ, Ruef BJ, Sneddon KM, Smith JR, Shimoyama M, Cabral F, Dumontet C, Dutcher SK, Harvey RJ, Lafanechère L, Murray JM, Nogales E, Piquemal D, Stanchi F, Povey S, Lovering RC
Genomics. 2007
PubMed ID: 17543498
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Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.
Koch HB, Zhang R, Verdoodt B, Bailey A, Zhang CD, Yates JR, Menssen A, Hermeking H
Cell Cycle. 2007
PubMed ID: 17314511
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Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA).
Wu SL, Kim J, Bandle RW, Liotta L, Petricoin E, Karger BL
Mol Cell Proteomics. 2006
PubMed ID: 16799092
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Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease.
Sacksteder CA, Qian WJ, Knyushko TV, Wang H, Chin MH, Lacan G, Melega WP, Camp DG, Smith RD, Smith DJ, Squier TC, Bigelow DJ
Biochemistry. 2006
PubMed ID: 16800626
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The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.
Petretti C, Savoian M, Montembault E, Glover DM, Prigent C, Giet R
EMBO Rep. 2006
PubMed ID: 16462731
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Tubulin nitration in human gliomas.
Fiore G, Di Cristo C, Monti G, Amoresano A, Columbano L, Pucci P, Cioffi FA, Di Cosmo A, Palumbo A, d'Ischia M
Neurosci Lett. 2006
PubMed ID: 16257120
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Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells.
Canani RB, De Marco G, Passariello A, Buccigrossi V, Ruotolo S, Bracale I, Porcaro F, Bifulco G, Guarino A
AIDS. 2006
PubMed ID: 16327313
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Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.
McCracken S, Longman D, Marcon E, Moens P, Downey M, Nickerson JA, Jessberger R, Wilde A, Caceres JF, Emili A, Blencowe BJ
J Biol Chem. 2005
PubMed ID: 16159877
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Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection.
Valenzuela-Fernández A, Alvarez S, Gordon-Alonso M, Barrero M, Ursa A, Cabrero JR, Fernández G, Naranjo-Suárez S, Yáñez-Mo M, Serrador JM, Muñoz-Fernández MA, Sánchez-Madrid F
Mol Biol Cell. 2005
PubMed ID: 16148047
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A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
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MYND domain specific interaction of the melanin-concentrating hormone receptor 1 interacting zinc-finger protein with alpha- and beta-tubulin.
Francke F, Buck F, Bächner D
Biochem Biophys Res Commun. 2005
PubMed ID: 16039987
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
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Tubulin polyglutamylase enzymes are members of the TTL domain protein family.
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Protein tyrosine nitration in rat brain is associated with raft proteins, flotillin-1 and alpha-tubulin: effect of biological aging.
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J Neurochem. 2005
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Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography.
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Mol Cell Proteomics. 2005
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Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
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Nature. 2005
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HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?
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Retrovirology. 2005
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Retrovirology. 2005
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Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
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Nat Biotechnol. 2005
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The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis.
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J Biol Chem. 2004
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Phosphoproteomic analysis of the developing mouse brain.
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Mol Cell Proteomics. 2004
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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Genome Res. 2004
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Genomic analysis of mouse retinal development.
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PLoS Biol. 2004
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Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
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Curr Biol. 2004
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Protein 4.1R, a microtubule-associated protein involved in microtubule aster assembly in mammalian mitotic extract.
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J Biol Chem. 2004
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Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro.
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Nature. 2004
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HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy.
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Proc Natl Acad Sci U S A. 2004
PubMed ID: 15103018
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Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions.
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Blood. 2004
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MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes.
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J Biol Chem. 2004
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Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding.
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J Biol Chem. 2004
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Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.
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Biochem Biophys Res Commun. 2004
PubMed ID: 14697242
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
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Nat Genet. 2004
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Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins.
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Neurochem Int. 2004
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Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.
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Dev Cell. 2003
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Identification of alpha-tubulin as an hsp105alpha-binding protein by the yeast two-hybrid system.
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Exp Cell Res. 2003
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The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability.
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J Biol Chem. 2003
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Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation.
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J Neurosci. 2003
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Rab8B GTPase and junction dynamics in the testis.
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Endocrinology. 2003
PubMed ID: 12639940
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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.
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Mol Cell. 2003
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Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.
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Mol Cell Biol. 2003
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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Proc Natl Acad Sci U S A. 2002
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HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.
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EMBO J. 2002
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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Nature. 2002
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Subcellular localization of the BRCA1 gene product in mitotic cells.
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Genes Chromosomes Cancer. 2002
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Tubulin is an inherent component of mitochondrial membranes that interacts with the voltage-dependent anion channel.
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Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.
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Mol Biol Cell. 2002
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Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex.
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Nat Cell Biol. 2002
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Nature. 2002
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Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin.
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Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells.
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Interaction between metabotropic glutamate receptor 7 and alpha tubulin.
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Role of MgcRacGAP/Cyk4 as a regulator of the small GTPase Rho family in cytokinesis and cell differentiation.
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Feierbach B, Nogales E, Downing KH, Stearns T
J Cell Biol. 1999
PubMed ID: 9885248
-
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
-
The microtubule-associated protein tau cross-links to two distinct sites on each alpha and beta tubulin monomer via separate domains.
Chau MF, Radeke MJ, de Inés C, Barasoain I, Kohlstaedt LA, Feinstein SC
Biochemistry. 1998
PubMed ID: 9922135
-
Tubulin and FtsZ structures: functional and therapeutic implications.
Desai A, Mitchison TJ
Bioessays. 1998
PubMed ID: 9722999
-
Characterization of the microtubule-binding domain of microtubule-associated protein 1A and its effects on microtubule dynamics.
Vaillant AR, Müller R, Langkopf A, Brown DL
J Biol Chem. 1998
PubMed ID: 9593747
-
Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors.
Tian G, Lewis SA, Feierbach B, Stearns T, Rommelaere H, Ampe C, Cowan NJ
J Cell Biol. 1997
PubMed ID: 9265649
-
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
-
Functionally distinct isoforms of dynactin are expressed in human neurons.
Tokito MK, Howland DS, Lee VM, Holzbaur EL
Mol Biol Cell. 1996
PubMed ID: 8856662
-
Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine.
Peters JD, Furlong MT, Asai DJ, Harrison ML, Geahlen RL
J Biol Chem. 1996
PubMed ID: 8617742
-
The Ras-related GTPase Rac1 binds tubulin.
Best A, Ahmed S, Kozma R, Lim L
J Biol Chem. 1996
PubMed ID: 8631991
-
Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells.
Huby RD, Carlile GW, Ley SC
J Biol Chem. 1995
PubMed ID: 8530437
-
Human T lymphocyte activation induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase.
Marie-Cardine A, Kirchgessner H, Eckerskorn C, Meuer SC, Schraven B
Eur J Immunol. 1995
PubMed ID: 8566014
-
The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro.
Alexandrova N, Niklinski J, Bliskovsky V, Otterson GA, Blake M, Kaye FJ, Zajac-Kaye M
Mol Cell Biol. 1995
PubMed ID: 7651436
-
Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.
Golsteyn RM, Mundt KE, Fry AM, Nigg EA
J Cell Biol. 1995
PubMed ID: 7790358
-
Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins.
Yamaguchi N, Fukuda MN
J Biol Chem. 1995
PubMed ID: 7744867
-
The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1).
Waterman-Storer CM, Karki S, Holzbaur EL
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7878030
-
In vitro analysis of microtubule assembly of isotypically pure tubulin dimers. Intrinsic differences in the assembly properties of alpha beta II, alpha beta III, and alpha beta IV tubulin dimers in the absence of microtubule-associated proteins.
Lu Q, Luduena RF
J Biol Chem. 1994
PubMed ID: 8294455
-
Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin.
Paschal BM, Holzbaur EL, Pfister KK, Clark S, Meyer DI, Vallee RB
J Biol Chem. 1993
PubMed ID: 8325901
-
The 93-kDa glycine receptor-associated protein binds to tubulin.
Kirsch J, Langosch D, Prior P, Littauer UZ, Schmitt B, Betz H
J Biol Chem. 1991
PubMed ID: 1657993
-
Alternative 5' exons either provide or deny an initiator methionine codon to the same alpha-tubulin coding region.
Dobner PR, Kislauskis E, Wentworth BM, Villa-Komaroff L
Nucleic Acids Res. 1987
PubMed ID: 3029670
-
Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes.
Villasante A, Wang D, Dobner P, Dolph P, Lewis SA, Cowan NJ
Mol Cell Biol. 1986
PubMed ID: 3785200
-
Structural features and restricted expression of a human alpha-tubulin gene.
Hall JL, Cowan NJ
Nucleic Acids Res. 1985
PubMed ID: 3839072
-
Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa.
Gogstad GO, Hagen I, Korsmo R, Solum NO
Biochim Biophys Acta. 1981
PubMed ID: 6457647
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