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TNFAIP3

Gene Description:   similar to Tumor necrosis factor, alpha-induced protein 3 (Putative DNA binding protein A20) (Zinc finger protein A20); tumor necrosis factor, alpha-induced protein 3 Synonyms:   Tnfaip3, TNFA1P2, MGC104522, A20, Tnfip3, TNFAIP3, MGC138687, OTUD7C, LOC683206, MGC138688 Orthologs:   Human TNFAIP3 (protein-coding), Mouse Tnfaip3 (protein-coding), Rat LOC683206 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, KEGG Human-Rat: KEGG Mouse-Rat: KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

(Human) GRCh37 - chr6:138188351..138204449 (16.10 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr10:18720716..18735463 (14.75 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas                 no data no data no data no data no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for TNFAIP3: The TNFAIP3 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs TNFAIP3   MED16   BioGRID  empirical  20211142  TNFAIP3   TNIP1   HPRD, MINT  empirical  10385526  12965196  11389905  TNFAIP3   KRR1   MINT  empirical    TNFAIP3   CHUK   HPRD, BioGRID  empirical  11594795  TNFAIP3   TICAM1   HPRD, MINT  empirical  15474016  TNFAIP3   CCDC50   HPRD  empirical  18029035  TNFAIP3   ALDH9A1   BioGRID  empirical  19615732  TNFAIP3   SSBP2   BioGRID  empirical  20211142  TNFAIP3   SSBP3   BioGRID  empirical  20211142  TNFAIP3   FBXO3   BioGRID  empirical  19615732  TNFAIP3   RNF11   HPRD, MINT, BioGRID  empirical  15231748  19131965  TNFAIP3   GLDC   BioGRID  empirical  19615732  TNFAIP3   TBK1   BioGRID  empirical  19615732  TNFAIP3   IKBKB   HPRD, BioGRID  empirical  11594795  TNFAIP3   KIF11   BioGRID  empirical  19615732  TNFAIP3   LAMP1   BioGRID  empirical  18329387  TNFAIP3   MCM6   BioGRID  empirical  19615732  TNFAIP3   NDUFS1   BioGRID  empirical  19615732  TNFAIP3   PPP2R1B   BioGRID  empirical  19615732  TNFAIP3   PPP6R3   BioGRID  empirical  19615732  TNFAIP3   LRRC47   BioGRID  empirical  19615732  TNFAIP3   RARRES3   BioGRID  empirical  16306043  TNFAIP3   RNH1   BioGRID  empirical  19615732  TNFAIP3   WNK1   IntAct  empirical  20936779  TNFAIP3   TNFAIP3   HPRD, MINT, BioGRID  empirical  8692885  11389905  8797804  TNFAIP3   TRAF1   HPRD, BioGRID  empirical  8692885  9928991  TNFAIP3   TRAF2   HPRD, IntAct  empirical  8692885  15102471  TNFAIP3   TRAF6   HPRD, IntAct, BioGRID  empirical  9928991  11463333  18164316  17703191  TNFAIP3   YWHAB   HPRD, BioGRID  empirical  8702721  19615732  TNFAIP3   YWHAE   HPRD, BioGRID  empirical  8702721  TNFAIP3   YWHAG   HPRD, IntAct, BioGRID  empirical  8702721  20936779  TNFAIP3   YWHAH   HPRD, BioGRID  empirical  8702721  9299557  19615732  TNFAIP3   YWHAZ   HPRD, BioGRID  empirical  9299557  8702721  20936779  TNFAIP3   ZFAND5   HPRD  empirical  14754897  TNFAIP3   LAPTM5   HPRD, MINT  empirical  15231748  TNFAIP3   TNIP2   HPRD, MINT, IntAct  empirical  11390377  10385526  11389905  15169888  TNFAIP3   CASP8   BioGRID  empirical  19060883  TNFAIP3   IKBKG   HPRD, MINT, BioGRID  empirical  10755617  11389905  20211142  TNFAIP3   RIPK1   HPRD, BioGRID  empirical  15258597  19131965  TNFAIP3   TAX1BP1   HPRD, MINT, BioGRID, Reactome  empirical  10435631  11389905

View all

KEGG Network: 2   Measles Human - 5162 Mouse - 5162 Rat - 5162 NOD-like receptor signaling pathway Human - 4621 Mouse - 4621 Rat - 4621

Biocarta: 3   CD40L Signaling Pathway Human Mouse NF-kB Signaling Pathway Human Mouse TNFR2 Signaling Pathway Human Mouse

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: 3   Canonical NF-kappaB pathway TNF receptor signaling pathway CD40/CD40L signaling

Gene Ontology: 63   B-1 B cell homeostasis GO:0001922 Protease binding GO:0002020 Activation of innate immune response GO:0002218 Response to molecule of bacterial origin GO:0002237 Regulation of germinal center formation GO:0002634 DNA binding GO:0003677 Ubiquitin thiolesterase activity GO:0004221 Ubiquitin-protein ligase activity GO:0004842 Ubiquitin-specific protease activity GO:0004843 Protein binding GO:0005515 Nucleus GO:0005634 Cytoplasm GO:0005737 Centrosome GO:0005813 Cytosol GO:0005829 Proteolysis GO:0006508 Apoptosis GO:0006915 Anti-apoptosis GO:0006916 Peptidase activity GO:0008233 Cysteine-type peptidase activity GO:0008234 Zinc ion binding GO:0008270 Protein deubiquitination GO:0016579 Ligase activity GO:0016874 Kinase binding GO:0019900 Negative regulation of protein ubiquitination GO:0031397 Negative regulation of NF-kappaB transcription factor activity GO:0032088 Negative regulation of type I interferon production GO:0032480 Response to muramyl dipeptide GO:0032495 Negative regulation of interleukin-1 beta production GO:0032691 Negative regulation of interleukin-2 production GO:0032703 Negative regulation of interleukin-6 production GO:0032715 Negative regulation of tumor necrosis factor production GO:0032720 Negative regulation of toll-like receptor 2 signaling pathway GO:0034136 Negative regulation of toll-like receptor 3 signaling pathway GO:0034140 Negative regulation of toll-like receptor 4 signaling pathway GO:0034144 Negative regulation of toll-like receptor 5 signaling pathway GO:0034148 Caspase inhibitor activity GO:0043027 Negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 Ubiquitin binding GO:0043130 Negative regulation of caspase activity GO:0043154 Protein self-association GO:0043621 Innate immune response GO:0045087 Positive regulation of protein catabolic process GO:0045732 Negative regulation of cyclin-dependent protein kinase activity GO:0045736 Negative regulation of bone resorption GO:0045779 Metal ion binding GO:0046872 Negative regulation of smooth muscle cell proliferation GO:0048662 Regulation of defense response to virus by host GO:0050691 Negative regulation of inflammatory response GO:0050728 Negative regulation of B cell activation GO:0050869 Protein oligomerization GO:0051259 Negative regulation of cell death GO:0060548 Regulation of vascular wound healing GO:0061043 Nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 Negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070429 Negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070433 Protein K63-linked deubiquitination GO:0070536 Protein K48-linked ubiquitination GO:0070936 Cellular response to lipopolysaccharide GO:0071222 Tolerance induction to lipopolysaccharide GO:0072573 Negative regulation of osteoclast proliferation GO:0090291 Positive regulation of hepatocyte proliferation GO:2000347 Negative regulation of CD40 signaling pathway GO:2000349 Negative regulation of endothelial cell apoptosis GO:2000352

	KEGG Network: 2 Measles Human - 5162 Mouse - 5162 Rat - 5162 NOD-like receptor signaling pathway Human - 4621 Mouse - 4621 Rat - 4621
	Biocarta: 3 CD40L Signaling Pathway Human Mouse NF-kB Signaling Pathway Human Mouse TNFR2 Signaling Pathway Human Mouse
	Reactome: None available
	NCI-Nature Pathway Interaction Database: 3 Canonical NF-kappaB pathway TNF receptor signaling pathway CD40/CD40L signaling
	Gene Ontology: 63 B-1 B cell homeostasis GO:0001922 Protease binding GO:0002020 Activation of innate immune response GO:0002218 Response to molecule of bacterial origin GO:0002237 Regulation of germinal center formation GO:0002634 DNA binding GO:0003677 Ubiquitin thiolesterase activity GO:0004221 Ubiquitin-protein ligase activity GO:0004842 Ubiquitin-specific protease activity GO:0004843 Protein binding GO:0005515 Nucleus GO:0005634 Cytoplasm GO:0005737 Centrosome GO:0005813 Cytosol GO:0005829 Proteolysis GO:0006508 Apoptosis GO:0006915 Anti-apoptosis GO:0006916 Peptidase activity GO:0008233 Cysteine-type peptidase activity GO:0008234 Zinc ion binding GO:0008270 Protein deubiquitination GO:0016579 Ligase activity GO:0016874 Kinase binding GO:0019900 Negative regulation of protein ubiquitination GO:0031397 Negative regulation of NF-kappaB transcription factor activity GO:0032088 Negative regulation of type I interferon production GO:0032480 Response to muramyl dipeptide GO:0032495 Negative regulation of interleukin-1 beta production GO:0032691 Negative regulation of interleukin-2 production GO:0032703 Negative regulation of interleukin-6 production GO:0032715 Negative regulation of tumor necrosis factor production GO:0032720 Negative regulation of toll-like receptor 2 signaling pathway GO:0034136 Negative regulation of toll-like receptor 3 signaling pathway GO:0034140 Negative regulation of toll-like receptor 4 signaling pathway GO:0034144 Negative regulation of toll-like receptor 5 signaling pathway GO:0034148 Caspase inhibitor activity GO:0043027 Negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 Ubiquitin binding GO:0043130 Negative regulation of caspase activity GO:0043154 Protein self-association GO:0043621 Innate immune response GO:0045087 Positive regulation of protein catabolic process GO:0045732 Negative regulation of cyclin-dependent protein kinase activity GO:0045736 Negative regulation of bone resorption GO:0045779 Metal ion binding GO:0046872 Negative regulation of smooth muscle cell proliferation GO:0048662 Regulation of defense response to virus by host GO:0050691 Negative regulation of inflammatory response GO:0050728 Negative regulation of B cell activation GO:0050869 Protein oligomerization GO:0051259 Negative regulation of cell death GO:0060548 Regulation of vascular wound healing GO:0061043 Nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 Negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070429 Negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070433 Protein K63-linked deubiquitination GO:0070536 Protein K48-linked ubiquitination GO:0070936 Cellular response to lipopolysaccharide GO:0071222 Tolerance induction to lipopolysaccharide GO:0072573 Negative regulation of osteoclast proliferation GO:0090291 Positive regulation of hepatocyte proliferation GO:2000347 Negative regulation of CD40 signaling pathway GO:2000349 Negative regulation of endothelial cell apoptosis GO:2000352

Type 1 Diabetes Publications: 9

• Uncoupling protein-2 knockout increases nitric oxide production and TNFAIP3 pathway activation in pancreatic islets.
  Nino Fong R, Fatehi-Hassanabad Z, Lee SC, Lu H, Wheeler MB, Chan C
  J Mol Endocrinol. 2011
  PubMed ID: 21321094
   
  
• A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.
  Budarf ML, Goyette P, Boucher G, Lian J, Graham RR, Claudio JO, Hudson T, Gladman D, Clarke AE, Pope JE, Peschken C, Smith CD, Hanly J, Rich E, Boire G, Barr SG, Zummer M, GenES Investigators, Fortin PR, Wither J, Rioux JD
  Genes Immun. 2010
  PubMed ID: 20962850
   
  
• African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity.
  Lodolce JP, Kolodziej LE, Rhee L, Kariuki SN, Franek BS, McGreal NM, Logsdon MF, Bartulis SJ, Perera MA, Ellis NA, Adams EJ, Hanauer SB, Jolly M, Niewold TB, Boone DL
  J Immunol. 2010
  PubMed ID: 20483768
   
  
• Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.
  Wang K, Baldassano R, Zhang H, Qu HQ, Imielinski M, Kugathasan S, Annese V, Dubinsky M, Rotter JI, Russell RK, Bradfield JP, Sleiman PM, Glessner JT, Walters T, Hou C, Kim C, Frackelton EC, Garris M, Doran J, Romano C, Catassi C, Van Limbergen J, Guthery SL, Denson L, Piccoli D, Silverberg MS, Stanley CA, Monos D, Wilson DC, Griffiths A, Grant SF, Satsangi J, Polychronakos C, Hakonarson H
  Hum Mol Genet. 2010
  PubMed ID: 20176734
   
  
• The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology.
  Vereecke L, Beyaert R, van Loo G
  Trends Immunol. 2009
  PubMed ID: 19643665
   
  
• Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.
  Fung EY, Smyth DJ, Howson JM, Cooper JD, Walker NM, Stevens H, Wicker LS, Todd JA
  Genes Immun. 2009
  PubMed ID: 19110536
   
  
• A new role for the anti-apoptotic gene A20 in angiogenesis.
  Chng HW, Camplejohn RS, Stone MG, Hart IR, Nicholson LJ
  Exp Cell Res. 2006
  PubMed ID: 16824518
   
  
• Nuclear factor-kappaB regulates beta-cell death: a critical role for A20 in beta-cell protection.
  Liuwantara D, Elliot M, Smith MW, Yam AO, Walters SN, Marino E, McShea A, Grey ST
  Diabetes. 2006
  PubMed ID: 16936197
   
  
• Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function.
  Grey ST, Longo C, Shukri T, Patel VI, Csizmadia E, Daniel S, Arvelo MB, Tchipashvili V, Ferran C
  J Immunol. 2003
  PubMed ID: 12794157
   
  

Publications: 186

• miR-29c targets TNFAIP3, inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma.
  Wang CM, Wang Y, Fan CG, Xu FF, Sun WS, Liu YG, Jia JH
  Biochem Biophys Res Commun. 2011
  PubMed ID: 21763284
   
  
• The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity.
  Kool M, van Loo G, Waelput W, De Prijck S, Muskens F, Sze M, van Praet J, Branco-Madeira F, Janssens S, Reizis B, Elewaut D, Beyaert R, Hammad H, Lambrecht BN
  Immunity. 2011
  PubMed ID: 21723156
   
  
• A20 is induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner.
  Matta H, Gopalakrishnan R, Punj V, Yi H, Suo Y, Chaudhary PM
  J Biol Chem. 2011
  PubMed ID: 21531730
   
  
• Sustained NF-kappaB activity in chronic lymphocytic leukemia is independent of genetic and epigenetic alterations in the TNFAIP3 (A20) locus.
  Frenzel LP, Claus R, Plume N, Schwamb J, Konermann C, Pallasch CP, Claasen J, Brinker R, Wollnik B, Plass C, Wendtner CM
  Int J Cancer. 2011
  PubMed ID: 20669229
   
  
• A20 (TNFAIP3) genetic alterations in EBV-associated AIDS-related lymphoma.
  Giulino L, Mathew S, Ballon G, Chadburn A, Barouk S, Antonicelli G, Leoncini L, Liu YF, Gogineni S, Tam W, Cesarman E
  Blood. 2011
  PubMed ID: 21406721
   
  
• [Significance of A20 in B-cell lymphomas].
  Kato M, Ogawa S
  Rinsho Ketsueki. 2011
  PubMed ID: 21566404
   
  
• Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC.
  Billmann-Born S, Till A, Arlt A, Lipinski S, Sina C, Latiano A, Annese V, Häsler R, Kerick M, Manke T, Seegert D, Hanidu A, Schäfer H, van Heel D, Li J, Schreiber S, Rosenstiel P
  J Immunol. 2011
  PubMed ID: 21335489
   
  
• The association between BANK1 and TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis.
  Fan Y, Tao JH, Zhang LP, Li LH, Ye DQ
  Int J Immunogenet. 2011
  PubMed ID: 21208380
   
  
• A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma.
  Dong G, Chanudet E, Zeng N, Appert A, Chen YW, Au WY, Hamoudi RA, Watkins AJ, Ye H, Liu H, Gao Z, Chuang SS, Srivastava G, Du MQ
  Clin Cancer Res. 2011
  PubMed ID: 21266526
   
  
• Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression.
  Xiong Y, Qiu F, Piao W, Song C, Wahl LM, Medvedev AE
  J Biol Chem. 2011
  PubMed ID: 21220427
   
  
• A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies.
  Hövelmeyer N, Reissig S, Xuan NT, Adams-Quack P, Lukas D, Nikolaev A, Schlüter D, Waisman A
  Eur J Immunol. 2011
  PubMed ID: 21341261
   
  
• Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.
  Adrianto I, Wen F, Templeton A, Wiley G, King JB, Lessard CJ, Bates JS, Hu Y, Kelly JA, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME, BIOLUPUS and GENLES Networks, Anaya JM, Bae SC, Bang SY, Boackle SA, Brown EE, Petri MA, Gallant C, Ramsey-Goldman R, Reveille JD, Vila LM, Criswell LA, Edberg JC, Freedman BI, Gregersen PK, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Park SY, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Moser KL, Webb CF, Humphrey MB, Montgomery CG, Gaffney PM
  Nat Genet. 2011
  PubMed ID: 21336280
   
  
• Regulation of inflammatory and antiviral signaling by A20.
  Parvatiyar K, Harhaj EW
  Microbes Infect. 2011
  PubMed ID: 21111841
   
  
• B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice.
  Chu Y, Vahl JC, Kumar D, Heger K, Bertossi A, Wójtowicz E, Soberon V, Schenten D, Mack B, Reutelshöfer M, Beyaert R, Amann K, van Loo G, Schmidt-Supprian M
  Blood. 2011
  PubMed ID: 21088135
   
  
• Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis.
  Mabilleau G, Chappard D, Sabokbar A
  J Biol Chem. 2011
  PubMed ID: 21127049
   
  
• Mucosal and systemic anti-HIV immunity controlled by A20 in mouse dendritic cells.
  Hong B, Song XT, Rollins L, Berry L, Huang XF, Chen SY
  J Clin Invest. 2011
  PubMed ID: 21206085
   
  
• A20 modulates lipid metabolism and energy production to promote liver regeneration.
  Damrauer SM, Studer P, da Silva CG, Longo CR, Ramsey HE, Csizmadia E, Shrikhande GV, Scali ST, Libermann TA, Bhasin MK, Ferran C
  PLoS One. 2011
  PubMed ID: 21437236
   
  
• Investigation of genetic susceptibility factors for human longevity - A targeted nonsynonymous SNP study.
  Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A
  Mutat Res. 2010
  PubMed ID: 20800603
   
  
• Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis.
  Bowes J, Lawrence R, Eyre S, Panoutsopoulou K, Orozco G, Elliott KS, Ke X, Morris AP, UKRAG, Thomson W, Worthington J, Barton A, Zeggini E
  Hum Genet. 2010
  PubMed ID: 20852893
   
  
• Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation.
  Won M, Park KA, Byun HS, Sohn KC, Kim YR, Jeon J, Hong JH, Park J, Seok JH, Kim JM, Yoon WH, Jang IS, Shen HM, Liu ZG, Hur GM
  Cell Death Differ. 2010
  PubMed ID: 20448643
   
  
• Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
  Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
  Haematologica. 2010
  PubMed ID: 21048031
   
  
• A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
  Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2, Strange A, Capon F, Spencer CC, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, Bergboer JG, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Cork MJ, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, Estivill X, Fitzgerald O, Freeman C, Giardina E, Gray E, Hofer A, Hüffmeier U, Hunt SE, Irvine AD, Jankowski J, Kirby B, Langford C, Lascorz J, Leman J, Leslie S, Mallbris L, Markus HS, Mathew CG, McLean WH, McManus R, Mössner R, Moutsianas L, Naluai AT, Nestle FO, Novelli G, Onoufriadis A, Palmer CN, Perricone C, Pirinen M, Plomin R, Potter SC, Pujol RM, Rautanen A, Riveira-Munoz E, Ryan AW, Salmhofer W, Samuelsson L, Sawcer SJ, Schalkwijk J, Smith CH, Ståhle M, Su Z, Tazi-Ahnini R, Traupe H, Viswanathan AC, Warren RB, Weger W, Wolk K, Wood N, Worthington J, Young HS, Zeeuwen PL, Hayday A, Burden AD, Griffiths CE, Kere J, Reis A, McVean G, Evans DM, Brown MA, Barker JN, Peltonen L, Donnelly P, Trembath RC
  Nat Genet. 2010
  PubMed ID: 20953190
   
  
• Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans.
  Hughes LB, Reynolds RJ, Brown EE, Kelley JM, Thomson B, Conn DL, Jonas BL, Westfall AO, Padilla MA, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Plenge RM, Bridges SL
  Arthritis Rheum. 2010
  PubMed ID: 20973039
   
  
• A genetic marker at the OLIG3/TNFAIP3 locus associates with methotrexate continuation in early inflammatory polyarthritis: results from the Norfolk Arthritis Register.
  Plant D, Farragher T, Flynn E, Martin P, Eyre S, Bunn D, Worthington J, Symmons D, Barton A, Thomson W
  Pharmacogenomics J. 2010
  PubMed ID: 20921970
   
  
• A human MAP kinase interactome.
  Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
  Nat Methods. 2010
  PubMed ID: 20936779
   
  
• Cleavage by MALT1 induces cytosolic release of A20.
  Malinverni C, Unterreiner A, Staal J, Demeyer A, Galaup M, Luyten M, Beyaert R, Bornancin F
  Biochem Biophys Res Commun. 2010
  PubMed ID: 20804738
   
  
• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
  Diabetes Care. 2010
  PubMed ID: 20628086
   
  
• Functional evaluation of TNFAIP3 (A20) in rheumatoid arthritis.
  Elsby LM, Orozco G, Denton J, Worthington J, Ray DW, Donn RP
  Clin Exp Rheumatol. 2010
  PubMed ID: 20822710
   
  
• Genetic variants in the prediction of rheumatoid arthritis.
  van der Helm-van Mil AH, Toes RE, Huizinga TW
  Ann Rheum Dis. 2010
  PubMed ID: 20439292
   
  
• The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.
  Tavares RM, Turer EE, Liu CL, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn BA, Ma A
  Immunity. 2010
  PubMed ID: 20705491
   
  
• Tumor suppressor A20 protects against cardiac hypertrophy and fibrosis by blocking transforming growth factor-beta-activated kinase 1-dependent signaling.
  Huang H, Tang QZ, Wang AB, Chen M, Yan L, Liu C, Jiang H, Yang Q, Bian ZY, Bai X, Zhu LH, Wang L, Li H
  Hypertension. 2010
  PubMed ID: 20585109
   
  
• A20 inhibits post-angioplasty restenosis by blocking macrophage trafficking and decreasing adventitial neovascularization.
  Damrauer SM, Fisher MD, Wada H, Siracuse JJ, da Silva CG, Moon K, Csizmadia E, Maccariello ER, Patel VI, Studer P, Essayagh S, Aird WC, Daniel S, Ferran C
  Atherosclerosis. 2010
  PubMed ID: 20430393
   
  
• Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis.
  Vereecke L, Sze M, Guire CM, Rogiers B, Chu Y, Schmidt-Supprian M, Pasparakis M, Beyaert R, van Loo G
  J Exp Med. 2010
  PubMed ID: 20530205
   
  
• Mutation analysis of the TNFAIP3 (A20) tumor suppressor gene in CLL.
  Philipp C, Edelmann J, Bühler A, Winkler D, Stilgenbauer S, Küppers R
  Int J Cancer. 2010
  PubMed ID: 20533286
   
  
• Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
  Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FA, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Brouwer E, Burtt NP, Catanese JJ, Coblyn J, Coenen MJ, Costenbader KH, Criswell LA, Crusius JB, Cui J, de Bakker PI, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Lee AT, Liu X, Martin P, Morgan AW, Padyukov L, Posthumus MD, Radstake TR, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, van der Schoot CE, van Riel PL, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth BP, YEAR Consortium, Wijmenga C, Karlson EW, Toes RE, de Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM
  Nat Genet. 2010
  PubMed ID: 20453842
   
  
• A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
  Kochi Y, Okada Y, Suzuki A, Ikari K, Terao C, Takahashi A, Yamazaki K, Hosono N, Myouzen K, Tsunoda T, Kamatani N, Furuichi T, Ikegawa S, Ohmura K, Mimori T, Matsuda F, Iwamoto T, Momohara S, Yamanaka H, Yamada R, Kubo M, Nakamura Y, Yamamoto K
  Nat Genet. 2010
  PubMed ID: 20453841
   
  
• Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.
  Tan RJ, Gibbons LJ, Potter C, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, BRAGGSS, Barton A
  Ann Rheum Dis. 2010
  PubMed ID: 20444755
   
  
• The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7.
  Ning S, Pagano JS
  J Virol. 2010
  PubMed ID: 20392859
   
  
• Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population.
  Dieudé P, Guedj M, Wipff J, Ruiz B, Riemekasten G, Matucci-Cerinic M, Melchers I, Hachulla E, Airo P, Diot E, Hunzelmann N, Cabane J, Mouthon L, Cracowski JL, Riccieri V, Distler J, Meyer O, Kahan A, Boileau C, Allanore Y
  Ann Rheum Dis. 2010
  PubMed ID: 20511617
   
  
• TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases.
  Parvatiyar K, Barber GN, Harhaj EW
  J Biol Chem. 2010
  PubMed ID: 20304918
   
  
• Lack of association between the rs6920220 (G/A) polymorphism of the 6q23 region and biopsy-proven giant cell arteritis.
  Palomino-Morales R, Torres O, Vazquez-Rodriguez TR, Castañeda S, Morado IC, Miranda-Filloy JA, Amigo-Diaz E, Callejas-Rubio JL, Fernandez-Gutierrez B, Martin J, Gonzalez-Gay MA
  J Rheumatol. 2010
  PubMed ID: 20231195
   
  
• Multiple common variants for celiac disease influencing immune gene expression.
  Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Adány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek WH, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA
  Nat Genet. 2010
  PubMed ID: 20190752
   
  
• A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis.
  Wieczorek S, Holle JU, Müller S, Fricke H, Gross WL, Epplen JT
  J Mol Med. 2010
  PubMed ID: 20049410
   
  
• Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.
  Karlson EW, Chibnik LB, Kraft P, Cui J, Keenan BT, Ding B, Raychaudhuri S, Klareskog L, Alfredsson L, Plenge RM
  Ann Rheum Dis. 2010
  PubMed ID: 20233754
   
  
• An atlas of combinatorial transcriptional regulation in mouse and man.
  Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
  Cell. 2010
  PubMed ID: 20211142
   
  
• Ca2+ influx via TRPC channels induces NF-kappaB-dependent A20 expression to prevent thrombin-induced apoptosis in endothelial cells.
  Thippegowda PB, Singh V, Sundivakkam PC, Xue J, Malik AB, Tiruppathi C
  Am J Physiol Cell Physiol. 2010
  PubMed ID: 20032510
   
  
• Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes.
  Shembade N, Ma A, Harhaj EW
  Science. 2010
  PubMed ID: 20185725
   
  
• The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population.
  Shimane K, Kochi Y, Horita T, Ikari K, Amano H, Hirakata M, Okamoto A, Yamada R, Myouzen K, Suzuki A, Kubo M, Atsumi T, Koike T, Takasaki Y, Momohara S, Yamanaka H, Nakamura Y, Yamamoto K
  Arthritis Rheum. 2010
  PubMed ID: 20112363
   
  
• A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation.
  Oshima N, Ishihara S, Rumi MA, Aziz MM, Mishima Y, Kadota C, Moriyama I, Ishimura N, Amano Y, Kinoshita Y
  Clin Exp Immunol. 2010
  PubMed ID: 19912257
   
  
• A20 is targeted by promoter methylation, deletion and inactivating mutation in MALT lymphoma.
  Chanudet E, Huang Y, Ichimura K, Dong G, Hamoudi RA, Radford J, Wotherspoon AC, Isaacson PG, Ferry J, Du MQ
  Leukemia. 2010
  PubMed ID: 19907439
   
  
• O-glycosylation regulates ubiquitination and degradation of the anti-inflammatory protein A20 to accelerate atherosclerosis in diabetic ApoE-null mice.
  Shrikhande GV, Scali ST, da Silva CG, Damrauer SM, Csizmadia E, Putheti P, Matthey M, Arjoon R, Patel R, Siracuse JJ, Maccariello ER, Andersen ND, Monahan T, Peterson C, Essayagh S, Studer P, Guedes RP, Kocher O, Usheva A, Veves A, Kaczmarek E, Ferran C
  PLoS One. 2010
  PubMed ID: 21151899
   
  
• Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study.
  Kawasaki A, Ito S, Furukawa H, Hayashi T, Goto D, Matsumoto I, Kusaoi M, Ohashi J, Graham RR, Matsuta K, Behrens TW, Tohma S, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N
  Arthritis Res Ther. 2010
  PubMed ID: 20849588
   
  
• Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
  Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer)
  PLoS Genet. 2010
  PubMed ID: 20628624
   
  
• Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population.
  Kawasaki A, Ito I, Ito S, Hayashi T, Goto D, Matsumoto I, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N
  J Biomed Biotechnol. 2010
  PubMed ID: 20617138
   
  
• Candidate genes for chromosomes 6 and 10 quantitative trait loci for age-related retinal degeneration in mice.
  Ogando DG, Dahlquist KD, Alizadeh M, Kunchithapautham K, Li J, Yu N, LaVail MM, Rohrer B, Vollrath D, Danciger M
  Mol Vis. 2010
  PubMed ID: 20577653
   
  
• TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy.
  Shi CS, Kehrl JH
  Sci Signal. 2010
  PubMed ID: 20501938
   
  
• Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort.
  Morgan AW, Robinson JI, Conaghan PG, Martin SG, Hensor EM, Morgan MD, Steiner L, Erlich HA, Gooi HC, Barton A, Worthington J, Emery P, UKRAG Consortium, YEAR Consortium
  Arthritis Res Ther. 2010
  PubMed ID: 20353580
   
  
• Targeting A20 decreases glioma stem cell survival and tumor growth.
  Hjelmeland AB, Wu Q, Wickman S, Eyler C, Heddleston J, Shi Q, Lathia JD, Macswords J, Lee J, McLendon RE, Rich JN
  PLoS Biol. 2010
  PubMed ID: 20186265
   
  
• Generation of human inflammation-resistant endothelial progenitor cells by A20 gene transfer.
  Liu JW, Dunoyer-Geindre S, Blot-Chabaud M, Sabatier F, Fish RJ, Bounameaux H, Dignat-George F, Kruithof EK
  J Vasc Res. 2010
  PubMed ID: 19851077
   
  
• A single-nucleotide polymorphism of the TNFAIP3 gene is associated with systemic lupus erythematosus in Chinese Han population.
  Cai LQ, Wang ZX, Lu WS, Han JW, Sun LD, Du WH, Zhang SM, Zuo XB, Zhang XJ, Yang S
  Mol Biol Rep. 2010
  PubMed ID: 19774492
   
  
• Mutations in the genes coding for the NF-κB regulating factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin's lymphoma.
  Schumacher MA, Schmitz R, Brune V, Tiacci E, Döring C, Hansmann ML, Siebert R, Küppers R
  Haematologica. 2010
  PubMed ID: 19648161
   
  
• Integrative predictive model of coronary artery calcification in atherosclerosis.
  McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF
  Circulation. 2009
  PubMed ID: 19948975
   
  
• A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
  Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
  Dev Cell. 2009
  PubMed ID: 20059953
   
  
• Association of TNFAIP3 polymorphism with rheumatic heart disease in Chinese Han population.
  Hua R, Xu JB, Wang JC, Zhu L, Li B, Liu Y, Huang SD, Jin L, Xu ZY, Wang XF
  Immunogenetics. 2009
  PubMed ID: 19902201
   
  
• Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.
  De Jager PL, Chibnik LB, Cui J, Reischl J, Lehr S, Simon KC, Aubin C, Bauer D, Heubach JF, Sandbrink R, Tyblova M, Lelkova P, Steering committee of the BENEFIT study, Steering committee of the BEYOND study, Steering committee of the LTF study, Steering committee of the CCR1 study, Havrdova E, Pohl C, Horakova D, Ascherio A, Hafler DA, Karlson EW
  Lancet Neurol. 2009
  PubMed ID: 19879194
   
  
• Impaired TNFalpha-induced A20 expression in E1A/Ras-transformed cells.
  Huang HL, Yeh WC, Lai MZ, Mirtsos C, Chau H, Chou CH, Benchimol S
  Br J Cancer. 2009
  PubMed ID: 19826422
   
  
• Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
  Am J Hum Genet. 2009
  PubMed ID: 19913121
   
  
• A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression.
  Ramsey HE, Da Silva CG, Longo CR, Csizmadia E, Studer P, Patel VI, Damrauer SM, Siracuse JJ, Daniel S, Ferran C
  Liver Transpl. 2009
  PubMed ID: 19877201
   
  
• Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
  Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, Xu JH, Cai ZM, Huang W, Zhao GP, Xie HF, Fang H, Lu QJ, Xu JH, Li XP, Pan YF, Deng DQ, Zeng FQ, Ye ZZ, Zhang XY, Wang QW, Hao F, Ma L, Zuo XB, Zhou FS, Du WH, Cheng YL, Yang JQ, Shen SK, Li J, Sheng YJ, Zuo XX, Zhu WF, Gao F, Zhang PL, Guo Q, Li B, Gao M, Xiao FL, Quan C, Zhang C, Zhang Z, Zhu KJ, Li Y, Hu DY, Lu WS, Huang JL, Liu SX, Li H, Ren YQ, Wang ZX, Yang CJ, Wang PG, Zhou WM, Lv YM, Zhang AP, Zhang SQ, Lin D, Li Y, Low HQ, Shen M, Zhai ZF, Wang Y, Zhang FY, Yang S, Liu JJ, Zhang XJ
  Nat Genet. 2009
  PubMed ID: 19838193
   
  
• Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10.
  Folco EJ, Rocha VZ, López-Ilasaca M, Libby P
  J Biol Chem. 2009
  PubMed ID: 19617629
   
  
• TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas.
  Honma K, Tsuzuki S, Nakagawa M, Tagawa H, Nakamura S, Morishima Y, Seto M
  Blood. 2009
  PubMed ID: 19608751
   
  
• Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
  Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C
  Gut. 2009
  PubMed ID: 19240061
   
  
• Defining the human deubiquitinating enzyme interaction landscape.
  Sowa ME, Bennett EJ, Gygi SP, Harper JW
  Cell. 2009
  PubMed ID: 19615732
   
  
• Ubiquitin-editing enzyme A20 promotes tolerance to lipopolysaccharide in enterocytes.
  Wang J, Ouyang Y, Guner Y, Ford HR, Grishin AV
  J Immunol. 2009
  PubMed ID: 19570823
   
  
• Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis.
  Prahalad S, Hansen S, Whiting A, Guthery SL, Clifford B, McNally B, Zeft AS, Bohnsack JF, Jorde LB
  Arthritis Rheum. 2009
  PubMed ID: 19565500
   
  
• A20 is overexpressed in glioma cells and may serve as a potential therapeutic target.
  Guo Q, Dong H, Liu X, Wang C, Liu N, Zhang J, Li B, Cao W, Ding T, Yang Z, Zhang X
  Expert Opin Ther Targets. 2009
  PubMed ID: 19492975
   
  
• Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.
  Bates JS, Lessard CJ, Leon JM, Nguyen T, Battiest LJ, Rodgers J, Kaufman KM, James JA, Gilkeson GS, Kelly JA, Humphrey MB, Harley JB, Gray-McGuire C, Moser KL, Gaffney PM
  Genes Immun. 2009
  PubMed ID: 19387456
   
  
• Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays.
  Fenner BJ, Scannell M, Prehn JH
  Biochim Biophys Acta. 2009
  PubMed ID: 19285159
   
  
• A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.
  Düwel M, Welteke V, Oeckinghaus A, Baens M, Kloo B, Ferch U, Darnay BG, Ruland J, Marynen P, Krappmann D
  J Immunol. 2009
  PubMed ID: 19494296
   
  
• Frequent inactivation of A20 in B-cell lymphomas.
  Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S
  Nature. 2009
  PubMed ID: 19412163
   
  
• A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men.
  Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, for the MrOS Research Group
  J Bone Miner Res. 2009
  PubMed ID: 19453261
   
  
• The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas.
  Novak U, Rinaldi A, Kwee I, Nandula SV, Rancoita PM, Compagno M, Cerri M, Rossi D, Murty VV, Zucca E, Gaidano G, Dalla-Favera R, Pasqualucci L, Bhagat G, Bertoni F
  Blood. 2009
  PubMed ID: 19258598
   
  
• TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.
  Schmitz R, Hansmann ML, Bohle V, Martin-Subero JI, Hartmann S, Mechtersheimer G, Klapper W, Vater I, Giefing M, Gesk S, Stanelle J, Siebert R, Küppers R
  J Exp Med. 2009
  PubMed ID: 19380639
   
  
• A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme.
  Malynn BA, Ma A
  J Exp Med. 2009
  PubMed ID: 19380636
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritis.
  Scherer HU, van der Linden MP, Kurreeman FA, Stoeken-Rijsbergen G, le Cessie S, Huizinga TW, van der Helm-van Mil AH, Toes RE
  Ann Rheum Dis. 2009
  PubMed ID: 19366996
   
  
• Determination of genetic predisposition to patent ductus arteriosus in preterm infants.
  Dagle JM, Lepp NT, Cooper ME, Schaa KL, Kelsey KJ, Orr KL, Caprau D, Zimmerman CR, Steffen KM, Johnson KJ, Marazita ML, Murray JC
  Pediatrics. 2009
  PubMed ID: 19336370
   
  
• Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis.
  Elder JT
  Genes Immun. 2009
  PubMed ID: 19262574
   
  
• The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling.
  Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW
  EMBO J. 2009
  PubMed ID: 19131965
   
  
• TNFalpha-induced macrophage death via caspase-dependent and independent pathways.
  Tran TM, Temkin V, Shi B, Pagliari L, Daniel S, Ferran C, Pope RM
  Apoptosis. 2009
  PubMed ID: 19152111
   
  
• ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development.
  Oshima S, Turer EE, Callahan JA, Chai S, Advincula R, Barrera J, Shifrin N, Lee B, Yen B, Woo T, Malynn BA, Ma A
  Nature. 2009
  PubMed ID: 19060883
   
  
• Polymorphisms in the tumour necrosis factor alpha-induced protein 3 (TNFAIP3) gene are associated with chronic rhinosinusitis.
  Cormier C, Bossé Y, Mfuna L, Hudson TJ, Desrosiers M
  J Otolaryngol Head Neck Surg. 2009
  PubMed ID: 19344623
   
  
• Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
  Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ, Ruether A, Schreiber S, Weichenthal M, Gladman D, Rahman P, Schrodi SJ, Prahalad S, Guthery SL, Fischer J, Liao W, Kwok PY, Menter A, Lathrop GM, Wise CA, Begovich AB, Voorhees JJ, Elder JT, Krueger GG, Bowcock AM, Abecasis GR, Collaborative Association Study of Psoriasis
  Nat Genet. 2009
  PubMed ID: 19169254
   
  
• The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation.
  Li L, Soetandyo N, Wang Q, Ye Y
  Biochim Biophys Acta. 2009
  PubMed ID: 18952128
   
  
• Attenuated expression of A20 markedly increases the efficacy of double-stranded RNA-activated dendritic cells as an anti-cancer vaccine.
  Breckpot K, Aerts-Toegaert C, Heirman C, Peeters U, Beyaert R, Aerts JL, Thielemans K
  J Immunol. 2009
  PubMed ID: 19124729
   
  
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
  Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
  Sci Signal. 2009
  PubMed ID: 19690332
   
  
• Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility.
  Dieguez-Gonzalez R, Calaza M, Perez-Pampin E, Balsa A, Blanco FJ, Cañete JD, Caliz R, Carreño L, de la Serna AR, Fernandez-Gutierrez B, Ortiz AM, Herrero-Beaumont G, Pablos JL, Narvaez J, Navarro F, Marenco JL, Gomez-Reino JJ, Gonzalez A
  Arthritis Res Ther. 2009
  PubMed ID: 19292917
   
  
• A20 overexpression inhibits low shear flow-induced CD14-positive monocyte recruitment to endothelial cells.
  Zeng W, Li L, Yuan W, Wei Y, Mi J, Sun J, Wen C, Zhang W, Ying D, Zhu C
  Biorheology. 2009
  PubMed ID: 19252225
   
  
• Gene-expression profiles of peripheral blood mononuclear cell subpopulations in acute graft-vs-host disease following cord blood transplantation.
  Takahashi N, Sato N, Takahashi S, Tojo A
  Exp Hematol. 2008
  PubMed ID: 18814951
   
  
• The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation.
  Lutz J, Luong le A, Strobl M, Deng M, Huang H, Anton M, Zakkar M, Enesa K, Chaudhury H, Haskard DO, Baumann M, Boyle J, Harten S, Maxwell PH, Pusey C, Heemann U, Evans PC
  J Mol Med. 2008
  PubMed ID: 18813897
   
  
• Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
  Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FA, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil AH, Neale BM, Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TW, Shadick NA, Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes RE, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ, Plenge RM
  Nat Genet. 2008
  PubMed ID: 18794853
   
  
• Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.
  Musone SL, Taylor KE, Lu TT, Nititham J, Ferreira RC, Ortmann W, Shifrin N, Petri MA, Kamboh MI, Manzi S, Seldin MF, Gregersen PK, Behrens TW, Ma A, Kwok PY, Criswell LA
  Nat Genet. 2008
  PubMed ID: 19165919
   
  
• Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
  Graham RR, Cotsapas C, Davies L, Hackett R, Lessard CJ, Leon JM, Burtt NP, Guiducci C, Parkin M, Gates C, Plenge RM, Behrens TW, Wither JE, Rioux JD, Fortin PR, Graham DC, Wong AK, Vyse TJ, Daly MJ, Altshuler D, Moser KL, Gaffney PM
  Nat Genet. 2008
  PubMed ID: 19165918
   
  
• Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20.
  Werner SL, Kearns JD, Zadorozhnaya V, Lynch C, O'Dea E, Boldin MP, Ma A, Baltimore D, Hoffmann A
  Genes Dev. 2008
  PubMed ID: 18676814
   
  
• Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signaling.
  Li L, Hailey DW, Soetandyo N, Li W, Lippincott-Schwartz J, Shu HB, Ye Y
  Biochim Biophys Acta. 2008
  PubMed ID: 18329387
   
  
• A20 is a negative regulator of BCL10- and CARMA3-mediated activation of NF-kappaB.
  Stilo R, Varricchio E, Liguoro D, Leonardi A, Vito P
  J Cell Sci. 2008
  PubMed ID: 18349075
   
  
• GUDMAP: the genitourinary developmental molecular anatomy project.
  McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
  J Am Soc Nephrol. 2008
  PubMed ID: 18287559
   
  
• The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals.
  Hitotsumatsu O, Ahmad RC, Tavares R, Wang M, Philpott D, Turer EE, Lee BL, Shiffin N, Advincula R, Malynn BA, Werts C, Ma A
  Immunity. 2008
  PubMed ID: 18342009
   
  
• T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20.
  Coornaert B, Baens M, Heyninck K, Bekaert T, Haegman M, Staal J, Sun L, Chen ZJ, Marynen P, Beyaert R
  Nat Immunol. 2008
  PubMed ID: 18223652
   
  
• Toward a confocal subcellular atlas of the human proteome.
  Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
  Mol Cell Proteomics. 2008
  PubMed ID: 18029348
   
  
• Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation.
  Iha H, Peloponese JM, Verstrepen L, Zapart G, Ikeda F, Smith CD, Starost MF, Yedavalli V, Heyninck K, Dikic I, Beyaert R, Jeang KT
  EMBO J. 2008
  PubMed ID: 18239685
   
  
• Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.
  Turer EE, Tavares RM, Mortier E, Hitotsumatsu O, Advincula R, Lee B, Shifrin N, Malynn BA, Ma A
  J Exp Med. 2008
  PubMed ID: 18268035
   
  
• Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20.
  Lin SC, Chung JY, Lamothe B, Rajashankar K, Lu M, Lo YC, Lam AY, Darnay BG, Wu H
  J Mol Biol. 2008
  PubMed ID: 18164316
   
  
• Interplay between E-box and NF-kappaB in regulation of A20 gene by DRB sensitivity-inducing factor (DSIF).
  Amir-Zilberstein L, Dikstein R
  J Biol Chem. 2008
  PubMed ID: 17962196
   
  
• Structure of the A20 OTU domain and mechanistic insights into deubiquitination.
  Komander D, Barford D
  Biochem J. 2008
  PubMed ID: 17961127
   
  
• TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in ocular adnexal marginal zone B cell lymphoma.
  Honma K, Tsuzuki S, Nakagawa M, Karnan S, Aizawa Y, Kim WS, Kim YD, Ko YH, Seto M
  Genes Chromosomes Cancer. 2008
  PubMed ID: 17886247
   
  
• Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.
  Plenge RM, Cotsapas C, Davies L, Price AL, de Bakker PI, Maller J, Pe'er I, Burtt NP, Blumenstiel B, DeFelice M, Parkin M, Barry R, Winslow W, Healy C, Graham RR, Neale BM, Izmailova E, Roubenoff R, Parker AN, Glass R, Karlson EW, Maher N, Hafler DA, Lee DM, Seldin MF, Remmers EF, Lee AT, Padyukov L, Alfredsson L, Coblyn J, Weinblatt ME, Gabriel SB, Purcell S, Klareskog L, Gregersen PK, Shadick NA, Daly MJ, Altshuler D
  Nat Genet. 2007
  PubMed ID: 17982456
   
  
• The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-kappaB target genes.
  Wolfrum S, Teupser D, Tan M, Chen KY, Breslow JL
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 18006655
   
  
• TNF pretreatment interferes with mitochondrial apoptosis in the mouse liver by A20-mediated down-regulation of Bax.
  Sass G, Shembade ND, Haimerl F, Lamoureux N, Hashemolhosseini S, Tannapfel A, Tiegs G
  J Immunol. 2007
  PubMed ID: 17982095
   
  
• IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway.
  Hutti JE, Turk BE, Asara JM, Ma A, Cantley LC, Abbott DW
  Mol Cell Biol. 2007
  PubMed ID: 17709380
   
  
• Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.
  Shembade N, Harhaj NS, Liebl DJ, Harhaj EW
  EMBO J. 2007
  PubMed ID: 17703191
   
  
• [Expressions of cytoprotective proteins for human renal allografts]
  Teng DH, Lu YP, Cao GH, Zhang HY, Li X, Wang L, Wang J, Li YP
  Sichuan Da Xue Xue Bao Yi Xue Ban. 2007
  PubMed ID: 17953374
   
  
• A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells.
  Vendrell JA, Ghayad S, Ben-Larbi S, Dumontet C, Mechti N, Cohen PA
  Oncogene. 2007
  PubMed ID: 17297453
   
  
• Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction.
  Li HL, Zhuo ML, Wang D, Wang AB, Cai H, Sun LH, Yang Q, Huang Y, Wei YS, Liu PP, Liu DP, Liang CC
  Circulation. 2007
  PubMed ID: 17389268
   
  
• Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes.
  Boonyasrisawat W, Eberle D, Bacci S, Zhang YY, Nolan D, Gervino EV, Johnstone MT, Trischitta V, Shoelson SE, Doria A
  Diabetes. 2007
  PubMed ID: 17259397
   
  
• The full-ORF clone resource of the German cDNA Consortium.
  Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blöcker H, Heubner D, Hoerlein A, Michel G, Wedler H, Köhrer K, Ottenwälder B, Poustka A, Wiemann S, Schupp I
  BMC Genomics. 2007
  PubMed ID: 17974005
   
  
• Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
  Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
  Cell. 2006
  PubMed ID: 17081983
   
  
• A global genomic transcriptional code associated with CNS-expressed genes.
  Bailey PJ, Klos JM, Andersson E, Karlén M, Källström M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J
  Exp Cell Res. 2006
  PubMed ID: 16919269
   
  
• ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB.
  Mauro C, Pacifico F, Lavorgna A, Mellone S, Iannetti A, Acquaviva R, Formisano S, Vito P, Leonardi A
  J Biol Chem. 2006
  PubMed ID: 16684768
   
  
• A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia.
  Patel VI, Daniel S, Longo CR, Shrikhande GV, Scali ST, Czismadia E, Groft CM, Shukri T, Motley-Dore C, Ramsey HE, Fisher MD, Grey ST, Arvelo MB, Ferran C
  FASEB J. 2006
  PubMed ID: 16816117
   
  
• Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20.
  Lin R, Yang L, Nakhaei P, Sun Q, Sharif-Askari E, Julkunen I, Hiscott J
  J Biol Chem. 2006
  PubMed ID: 16306043
   
  
• Neuroprotective effect of A20 on TNF-induced postischemic apoptosis.
  Yu L, Miao H, Hou Y, Zhang B, Guo L
  Neurochem Res. 2006
  PubMed ID: 16474993
   
  
• Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells.
  Kunter U, Daniel S, Arvelo MB, Choi J, Shukri T, Patel VI, Longo CR, Scali ST, Shrikhande G, Rocha E, Czismadia E, Mottley C, Grey ST, Floege J, Ferran C
  Kidney Int. 2005
  PubMed ID: 16164629
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism.
  Longo CR, Patel VI, Shrikhande GV, Scali ST, Csizmadia E, Daniel S, Sun DW, Grey ST, Arvelo MB, Ferran C
  Hepatology. 2005
  PubMed ID: 15962316
   
  
• A20 gene expression is regulated by TNF, Vitamin D and androgen in prostate cancer cells.
  Golovko O, Nazarova N, Tuohimaa P
  J Steroid Biochem Mol Biol. 2005
  PubMed ID: 15862966
   
  
• A20 is a negative regulator of IFN regulatory factor 3 signaling.
  Saitoh T, Yamamoto M, Miyagishi M, Taira K, Nakanishi M, Fujita T, Akira S, Yamamoto N, Yamaoka S
  J Immunol. 2005
  PubMed ID: 15661910
   
  
• Core promoter binding by histone-like TAF complexes.
  Shao H, Revach M, Moshonov S, Tzuman Y, Gazit K, Albeck S, Unger T, Dikstein R
  Mol Cell Biol. 2005
  PubMed ID: 15601843
   
  
• Mouse brain organization revealed through direct genome-scale TF expression analysis.
  Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
  Science. 2004
  PubMed ID: 15618518
   
  
• A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation.
  Daniel S, Arvelo MB, Patel VI, Longo CR, Shrikhande G, Shukri T, Mahiou J, Sun DW, Mottley C, Grey ST, Ferran C
  Blood. 2004
  PubMed ID: 15251990
   
  
• A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter.
  Wang YY, Li L, Han KJ, Zhai Z, Shu HB
  FEBS Lett. 2004
  PubMed ID: 15474016
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses.
  Boone DL, Turer EE, Lee EG, Ahmad RC, Wheeler MT, Tsui C, Hurley P, Chien M, Chai S, Hitotsumatsu O, McNally E, Pickart C, Ma A
  Nat Immunol. 2004
  PubMed ID: 15334086
   
  
• Genomic analysis of mouse retinal development.
  Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
  PLoS Biol. 2004
  PubMed ID: 15226823
   
  
• A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells.
  Gon Y, Asai Y, Hashimoto S, Mizumura K, Jibiki I, Machino T, Ra C, Horie T
  Am J Respir Cell Mol Biol. 2004
  PubMed ID: 15142865
   
  
• De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.
  Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM
  Nature. 2004
  PubMed ID: 15258597
   
  
• Functional proteomics mapping of a human signaling pathway.
  Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM
  Genome Res. 2004
  PubMed ID: 15231748
   
  
• ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.
  Lang V, Symons A, Watton SJ, Janzen J, Soneji Y, Beinke S, Howell S, Ley SC
  Mol Cell Biol. 2004
  PubMed ID: 15169888
   
  
• ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation.
  Huang J, Teng L, Li L, Liu T, Li L, Chen D, Xu LG, Zhai Z, Shu HB
  J Biol Chem. 2004
  PubMed ID: 14754897
   
  
• Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity.
  Evans PC, Ovaa H, Hamon M, Kilshaw PJ, Hamm S, Bauer S, Ploegh HL, Smith TS
  Biochem J. 2004
  PubMed ID: 14748687
   
  
• Complete sequencing and characterization of 21,243 full-length human cDNAs.
  Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
  Nat Genet. 2004
  PubMed ID: 14702039
   
  
• A20, a regulator of NFkappaB, maps to an atherosclerosis locus and differs between parental sensitive C57BL/6J and resistant FVB/N strains.
  Idel S, Dansky HM, Breslow JL
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 14614151
   
  
• The DNA sequence and analysis of human chromosome 6.
  Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
  Nature. 2003
  PubMed ID: 14574404
   
  
• Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays.
  Gallagher J, Howlin J, McCarthy C, Murphy EP, Bresnihan B, FitzGerald O, Godson C, Brady HR, Martin F
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• A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis.
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• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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  PubMed ID: 12477932
   
  
• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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  Nature. 2002
  PubMed ID: 12466851
   
  
• A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells.
  He KL, Ting AT
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  PubMed ID: 12167698
   
  
• The promyelocytic leukemia protein represses A20-mediated transcription.
  Wu WS, Xu ZX, Chang KS
  J Biol Chem. 2002
  PubMed ID: 12080044
   
  
• A phenotype-sensitizing Apoe-deficient genetic background reveals novel atherosclerosis predisposition loci in the mouse.
  Dansky HM, Shu P, Donavan M, Montagno J, Nagle DL, Smutko JS, Roy N, Whiteing S, Barrios J, McBride TJ, Smith JD, Duyk G, Breslow JL, Moore KJ
  Genetics. 2002
  PubMed ID: 11973313
   
  
• A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome.
  Zetoune FS, Murthy AR, Shao Z, Hlaing T, Zeidler MG, Li Y, Vincenz C
  Cytokine. 2001
  PubMed ID: 11594795
   
  
• Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
  Piao Y, Ko NT, Lim MK, Ko MS
  Genome Res. 2001
  PubMed ID: 11544199
   
  
• Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2.
  Van Huffel S, Delaei F, Heyninck K, De Valck D, Beyaert R
  J Biol Chem. 2001
  PubMed ID: 11390377
   
  
• Expression of different NF-kappaB pathway genes in dendritic cells (DCs) or macrophages assessed by gene expression profiling.
  Baltathakis I, Alcantara O, Boldt DH
  J Cell Biochem. 2001
  PubMed ID: 11573245
   
  
• Isolation and characterization of two novel A20-like proteins.
  Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ
  Biochem J. 2001
  PubMed ID: 11463333
   
  
• Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions.
  Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R
  FEBS Lett. 2001
  PubMed ID: 11389905
   
  
• Functional annotation of a full-length mouse cDNA collection.
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  PubMed ID: 11217851
   
  
• RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
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  PubMed ID: 11076861
   
  
• Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
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  Genome Res. 2000
  PubMed ID: 11042159
   
  
• Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice.
  Lee EG, Boone DL, Chai S, Libby SL, Chien M, Lodolce JP, Ma A
  Science. 2000
  PubMed ID: 11009421
   
  
• Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation.
  Zhang SQ, Kovalenko A, Cantarella G, Wallach D
  Immunity. 2000
  PubMed ID: 10755617
   
  
• The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.
  De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R
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  PubMed ID: 10435631
   
  
• The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN.
  Heyninck K, De Valck D, Vanden Berghe W, Van Criekinge W, Contreras R, Fiers W, Haegeman G, Beyaert R
  J Cell Biol. 1999
  PubMed ID: 10385526
   
  
• Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2.
  Eliopoulos AG, Blake SM, Floettmann JE, Rowe M, Young LS
  J Virol. 1999
  PubMed ID: 9882303
   
  
• The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6.
  Heyninck K, Beyaert R
  FEBS Lett. 1999
  PubMed ID: 9928991
   
  
• High-efficiency full-length cDNA cloning.
  Carninci P, Hayashizaki Y
  Methods Enzymol. 1999
  PubMed ID: 10349636
   
  
• Major histocompatibility complex class I- and II-deficient knock-out mice are resistant to primary but susceptible to secondary Eimeria papillata infections.
  Schito ML, Chobotar B, Barta JR
  Parasitol Res. 1998
  PubMed ID: 9610637
   
  
• A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins.
  De Valck D, Heyninck K, Van Criekinge W, Vandenabeele P, Fiers W, Beyaert R
  Biochem Biophys Res Commun. 1997
  PubMed ID: 9299557
   
  
• 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules.
  Vincenz C, Dixit VM
  J Biol Chem. 1996
  PubMed ID: 8702721
   
  
• A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism.
  Cooper JT, Stroka DM, Brostjan C, Palmetshofer A, Bach FH, Ferran C
  J Biol Chem. 1996
  PubMed ID: 8663499
   
  
• The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.
  Song HY, Rothe M, Goeddel DV
  Proc Natl Acad Sci U S A. 1996
  PubMed ID: 8692885
   
  
• A20, an inhibitor of cell death, self-associates by its zinc finger domain.
  De Valck D, Heyninck K, Van Criekinge W, Contreras R, Beyaert R, Fiers W
  FEBS Lett. 1996
  PubMed ID: 8797804
   
  
• Lymphoid expression and regulation of A20, an inhibitor of programmed cell death.
  Tewari M, Wolf FW, Seldin MF, O'Shea KS, Dixit VM, Turka LA
  J Immunol. 1995
  PubMed ID: 7836754
   
  
• The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.
  Opipari AW, Boguski MS, Dixit VM
  J Biol Chem. 1990
  PubMed ID: 2118515
   
  
• Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin.
  Dixit VM, Green S, Sarma V, Holzman LB, Wolf FW, O'Rourke K, Ward PA, Prochownik EV, Marks RM
  J Biol Chem. 1990
  PubMed ID: 2406243
   
  

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