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TH

Gene Description:   tyrosine hydroxylase Synonyms:   TYH, TH, DYT14, DYT5b, Th, The Orthologs:   Human TH (protein-coding), Mouse Th (protein-coding), Rat Th (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Human-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 2 Rat: 3

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
11p15.5	Human	chr11:2068424..2308304	0.24	37	rs689 rs7111341

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Not assigned	Mouse	chr7:117936155..152524553	34.59	560

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 11p15.5 Orthologous Region	Mouse	chr7:149800921..150160408	0.36	6
Human 11p15.5 Orthologous Region	Rat	chr1:202870115..203251634	0.38	4
Iddm25	Rat	chr1:193831373..230411453	36.58	766

(Human) GRCh37 - chr11:2185159..2193107 (7.95 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr7:150078657..150117033 (38.38 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr1:203164253..203171514 (7.26 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for TH: The TH interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs TH   CSNK2A1   HPRD  empirical  14675149  TH   PRKACA   HPRD  empirical  2874140  11359875  TH   MAPK1   HPRD, BioGRID  empirical  14570886  1347949  TH   MAPK3   HPRD, MINT, BioGRID  empirical  1347949  19935650  TH   SNCA   HPRD, BioGRID  empirical  11943812  TH   YWHAB   HPRD  empirical  14675149  TH   YWHAZ   HPRD  empirical  11359875  TH   CAMK2G   HPRD  empirical  6150037  11359875  TH   RPS6KA5   HPRD  empirical  12421349  TH   MAPKAPK2   HPRD  empirical  6150037  11359875  7901013

View all

KEGG Network: 3   Metabolic pathways Human - 1100 Mouse - 1100 Rat - 1100 Parkinson's disease Human - 5012 Mouse - 5012 Rat - 5012 Tyrosine metabolism Human - 350 Mouse - 350 Rat - 350

Biocarta: None available   None available.

Reactome: 9   Amine-derived hormones REACT_15513 Catecholamine biosynthesis REACT_15551 Dopamine Neurotransmitter Release Cycle REACT_15293 Hormone biosynthesis REACT_15314 Metabolism of amino acids and derivatives REACT_13 Neurotransmitter Release Cycle REACT_13723 Synaptic Transmission REACT_13685 Synthesis of Dopamine REACT_15431 Transmission across Chemical Synapses REACT_13477

NCI-Nature Pathway Interaction Database: 4   AP-1 transcription factor network ATF-2 transcription factor network Alpha-synuclein signaling p38 signaling mediated by MAPKAP kinases

Gene Ontology: 89   Response to hypoxia GO:0001666 Synaptic transmission, dopaminergic GO:0001963 Response to amphetamine GO:0001975 Heart morphogenesis GO:0003007 Tyrosine 3-monooxygenase activity GO:0004511 Iron ion binding GO:0005506 Protein binding GO:0005515 Nucleus GO:0005634 Cytoplasm GO:0005737 Mitochondrion GO:0005739 Smooth endoplasmic reticulum GO:0005790 Cytosol GO:0005829 Dopamine biosynthetic process from tyrosine GO:0006585 Fatty acid metabolic process GO:0006631 Sphingolipid metabolic process GO:0006665 Synaptic transmission GO:0007268 Neurotransmitter secretion GO:0007269 Heart development GO:0007507 Visual perception GO:0007601 Sensory perception of sound GO:0007605 Learning GO:0007612 Memory GO:0007613 Mating behavior GO:0007617 Locomotory behavior GO:0007626 Regulation of heart contraction GO:0008016 Synaptic vesicle GO:0008021 Ferrous iron binding GO:0008198 Ferric iron binding GO:0008199 Aromatic amino acid family metabolic process GO:0009072 Response to water deprivation GO:0009414 Response to light stimulus GO:0009416 Response to herbicide GO:0009635 Response to salt stress GO:0009651 Anatomical structure morphogenesis GO:0009653 Organ morphogenesis GO:0009887 Internal side of plasma membrane GO:0009898 Response to zinc ion GO:0010043 Multicellular organismal aging GO:0010259 Response to activity GO:0014823 Synaptic vesicle amine transport GO:0015842 O-glycoside metabolic process GO:0016140 Amino acid binding GO:0016597 Phthalate metabolic process GO:0018963 Synaptosome GO:0019717 Oxygen binding GO:0019825 Protein domain specific binding GO:0019904 Cerebral cortex development GO:0021987 Axon GO:0030424 Dendrite GO:0030425 Cytoplasmic vesicle GO:0031410 Response to nutrient levels GO:0031667 Response to estradiol stimulus GO:0032355 Response to lipopolysaccharide GO:0032496 Isoquinoline alkaloid metabolic process GO:0033076 Melanosome membrane GO:0033162 Tetrahydrobiopterin binding GO:0034617 Cellular nitrogen compound metabolic process GO:0034641 Social behavior GO:0035176 Dopamine binding GO:0035240 Cellular response to drug GO:0035690 Neurotransmitter biosynthetic process GO:0042136 Terpene metabolic process GO:0042214 Dopamine biosynthetic process GO:0042416 Epinephrine biosynthetic process GO:0042418 Norepinephrine biosynthetic process GO:0042421 Hormone biosynthetic process GO:0042446 Eye photoreceptor cell development GO:0042462 Circadian sleep/wake cycle GO:0042745 Eating behavior GO:0042755 Neuron projection GO:0043005 Terminal button GO:0043195 Perikaryon GO:0043204 Response to peptide hormone stimulus GO:0043434 Pigmentation GO:0043473 Response to ethanol GO:0045471 Response to ether GO:0045472 Response to pyrethroid GO:0046684 Metal ion binding GO:0046872 Response to steroid hormone stimulus GO:0048545 Embryonic camera-type eye morphogenesis GO:0048596 Cognition GO:0050890 Response to corticosterone stimulus GO:0051412 Response to electrical stimulus GO:0051602 Phytoalexin metabolic process GO:0052314 Oxidation-reduction process GO:0055114 Cellular response to manganese ion GO:0071287 Cellular response to nicotine GO:0071316 Cellular response to glucose stimulus GO:0071333 Cellular response to growth factor stimulus GO:0071363

	KEGG Network: 3 Metabolic pathways Human - 1100 Mouse - 1100 Rat - 1100 Parkinson's disease Human - 5012 Mouse - 5012 Rat - 5012 Tyrosine metabolism Human - 350 Mouse - 350 Rat - 350
	Biocarta: None available
	Reactome: 9 Amine-derived hormones REACT_15513 Catecholamine biosynthesis REACT_15551 Dopamine Neurotransmitter Release Cycle REACT_15293 Hormone biosynthesis REACT_15314 Metabolism of amino acids and derivatives REACT_13 Neurotransmitter Release Cycle REACT_13723 Synaptic Transmission REACT_13685 Synthesis of Dopamine REACT_15431 Transmission across Chemical Synapses REACT_13477
	NCI-Nature Pathway Interaction Database: 4 AP-1 transcription factor network ATF-2 transcription factor network Alpha-synuclein signaling p38 signaling mediated by MAPKAP kinases
	Gene Ontology: 89 Response to hypoxia GO:0001666 Synaptic transmission, dopaminergic GO:0001963 Response to amphetamine GO:0001975 Heart morphogenesis GO:0003007 Tyrosine 3-monooxygenase activity GO:0004511 Iron ion binding GO:0005506 Protein binding GO:0005515 Nucleus GO:0005634 Cytoplasm GO:0005737 Mitochondrion GO:0005739 Smooth endoplasmic reticulum GO:0005790 Cytosol GO:0005829 Dopamine biosynthetic process from tyrosine GO:0006585 Fatty acid metabolic process GO:0006631 Sphingolipid metabolic process GO:0006665 Synaptic transmission GO:0007268 Neurotransmitter secretion GO:0007269 Heart development GO:0007507 Visual perception GO:0007601 Sensory perception of sound GO:0007605 Learning GO:0007612 Memory GO:0007613 Mating behavior GO:0007617 Locomotory behavior GO:0007626 Regulation of heart contraction GO:0008016 Synaptic vesicle GO:0008021 Ferrous iron binding GO:0008198 Ferric iron binding GO:0008199 Aromatic amino acid family metabolic process GO:0009072 Response to water deprivation GO:0009414 Response to light stimulus GO:0009416 Response to herbicide GO:0009635 Response to salt stress GO:0009651 Anatomical structure morphogenesis GO:0009653 Organ morphogenesis GO:0009887 Internal side of plasma membrane GO:0009898 Response to zinc ion GO:0010043 Multicellular organismal aging GO:0010259 Response to activity GO:0014823 Synaptic vesicle amine transport GO:0015842 O-glycoside metabolic process GO:0016140 Amino acid binding GO:0016597 Phthalate metabolic process GO:0018963 Synaptosome GO:0019717 Oxygen binding GO:0019825 Protein domain specific binding GO:0019904 Cerebral cortex development GO:0021987 Axon GO:0030424 Dendrite GO:0030425 Cytoplasmic vesicle GO:0031410 Response to nutrient levels GO:0031667 Response to estradiol stimulus GO:0032355 Response to lipopolysaccharide GO:0032496 Isoquinoline alkaloid metabolic process GO:0033076 Melanosome membrane GO:0033162 Tetrahydrobiopterin binding GO:0034617 Cellular nitrogen compound metabolic process GO:0034641 Social behavior GO:0035176 Dopamine binding GO:0035240 Cellular response to drug GO:0035690 Neurotransmitter biosynthetic process GO:0042136 Terpene metabolic process GO:0042214 Dopamine biosynthetic process GO:0042416 Epinephrine biosynthetic process GO:0042418 Norepinephrine biosynthetic process GO:0042421 Hormone biosynthetic process GO:0042446 Eye photoreceptor cell development GO:0042462 Circadian sleep/wake cycle GO:0042745 Eating behavior GO:0042755 Neuron projection GO:0043005 Terminal button GO:0043195 Perikaryon GO:0043204 Response to peptide hormone stimulus GO:0043434 Pigmentation GO:0043473 Response to ethanol GO:0045471 Response to ether GO:0045472 Response to pyrethroid GO:0046684 Metal ion binding GO:0046872 Response to steroid hormone stimulus GO:0048545 Embryonic camera-type eye morphogenesis GO:0048596 Cognition GO:0050890 Response to corticosterone stimulus GO:0051412 Response to electrical stimulus GO:0051602 Phytoalexin metabolic process GO:0052314 Oxidation-reduction process GO:0055114 Cellular response to manganese ion GO:0071287 Cellular response to nicotine GO:0071316 Cellular response to glucose stimulus GO:0071333 Cellular response to growth factor stimulus GO:0071363

Type 1 Diabetes Publications: 8

• Diabetes induces changes of catecholamines in primary mesangial cells.
  Marco GS, Colucci JA, Fernandes FB, Vio CP, Schor N, Casarini DE
  Int J Biochem Cell Biol. 2008
  PubMed ID: 18037336
   
  
• Embryonic sympathoblasts transiently express TrkB in vivo and proliferate in response to brain-derived neurotrophic factor in vitro.
  Straub JA, Sholler GL, Nishi R
  BMC Dev Biol. 2007
  PubMed ID: 17309801
   
  
• IDDM2 and the polymorphism of the human tyrosine hydroxylase (hTH) gene in African Americans with type-1 diabetes.
  Berka N, Nunlee-Bland G, Erabhaoui E, Belmamoun M, Dunston GM
  J Natl Med Assoc. 2004
  PubMed ID: 15303408
   
  
• Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits.
  Rodríguez S, Gaunt TR, O'Dell SD, Chen XH, Gu D, Hawe E, Miller GJ, Humphries SE, Day IN
  Hum Mol Genet. 2004
  PubMed ID: 14749349
   
  
• Multicentre Italian family-based association study on tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders.
  Serretti A, Cusin C, Cristina S, Lorenzi C, Lilli R, Lattuada E, Grieco G, Costa A, Santorelli F, Barale F, Smeraldi E, Nappi G
  Psychiatr Genet. 2003
  PubMed ID: 12782971
   
  
• Low insulin resistance and preserved beta-cell function contribute to human longevity but are not associated with TH-INS genes.
  Paolisso G, Barbieri M, Rizzo MR, Carella C, Rotondi M, Bonafè M, Franceschi C, Rose G, De Benedictis G
  Exp Gerontol. 2001
  PubMed ID: 11738155
   
  
• Pax6 regulates the identity of embryonic diencephalic neurons.
  Mastick GS, Andrews GL
  Mol Cell Neurosci. 2001
  PubMed ID: 11161479
   
  
• Immunohistochemical investigation of tyrosine-hydroxylase in the islets of Langerhans of adult mice, rats and guinea pigs.
  Iturriza FC, Thibault J
  Neuroendocrinology. 1993
  PubMed ID: 8100618
   
  

Publications: 838

• Activation of cerebral peroxisome proliferator-activated receptors γ (PPARγ) reduces neuronal damage in the substantia nigra after transient focal cerebral ischaemia in the rat.
  Zuhayra M, Zhao Y, von Forstner C, Henze E, Gohlke P, Culman J, Lützen U
  Neuropathol Appl Neurobiol. 2011
  PubMed ID: 21366664
   
  
• Changes with aging in the dopaminergic and noradrenergic innervation of rat neocortex.
  Allard S, Gosein V, Cuello AC, Ribeiro-da-Silva A
  Neurobiol Aging. 2011
  PubMed ID: 20096955
   
  
• Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.
  Matsuoka RL, Chivatakarn O, Badea TC, Samuels IS, Cahill H, Katayama K, Kumar SR, Suto F, Chédotal A, Peachey NS, Nathans J, Yoshida Y, Giger RJ, Kolodkin AL
  Neuron. 2011
  PubMed ID: 21835343
   
  
• Analysis of Cdh22 expression and function in the developing mouse brain.
  Saarimäki-Vire J, Alitalo A, Partanen J
  Dev Dyn. 2011
  PubMed ID: 21761482
   
  
• Association of TH01 with human longevity revisited.
  von Wurmb-Schwark N, Caliebe A, Schwark T, Kleindorp R, Poetsch M, Schreiber S, Nebel A
  Eur J Hum Genet. 2011
  PubMed ID: 21407269
   
  
• Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson's disease.
  García C, Palomo-Garo C, García-Arencibia M, Ramos J, Pertwee R, Fernández-Ruiz J
  Br J Pharmacol. 2011
  PubMed ID: 21323909
   
  
• Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis.
  Ferrón SR, Charalambous M, Radford E, McEwen K, Wildner H, Hind E, Morante-Redolat JM, Laborda J, Guillemot F, Bauer SR, Fariñas I, Ferguson-Smith AC
  Nature. 2011
  PubMed ID: 21776083
   
  
• An extended domain of Kcnq1ot1 silencing revealed by an imprinted fluorescent reporter.
  Jones MJ, Bogutz AB, Lefebvre L
  Mol Cell Biol. 2011
  PubMed ID: 21576366
   
  
• Netrin1 is required for neural and glial precursor migrations into the olfactory bulb.
  Hakanen J, Duprat S, Salminen M
  Dev Biol. 2011
  PubMed ID: 21545793
   
  
• The transcription factors AP-2β and AP-2α are required for survival of sympathetic progenitors and differentiated sympathetic neurons.
  Schmidt M, Huber L, Majdazari A, Schütz G, Williams T, Rohrer H
  Dev Biol. 2011
  PubMed ID: 21539825
   
  
• Renin expression in large renal vessels during fetal development depends on functional beta1/beta2-adrenergic receptors.
  Neubauer B, Machura K, Schnermann J, Wagner C
  Am J Physiol Renal Physiol. 2011
  PubMed ID: 21389089
   
  
• Specification of a Foxj1-dependent lineage in the forebrain is required for embryonic-to-postnatal transition of neurogenesis in the olfactory bulb.
  Jacquet BV, Muthusamy N, Sommerville LJ, Xiao G, Liang H, Zhang Y, Holtzman MJ, Ghashghaei HT
  J Neurosci. 2011
  PubMed ID: 21697387
   
  
• Role of the dopamine transporter in mediating the neuroleptic-induced reduction of tyrosine hydroxylase-immunoreactive midbrain neurons.
  Reynolds KB, MacGillivray L, Zettler M, Rosebush PI, Mazurek MF
  Brain Res. 2011
  PubMed ID: 21396352
   
  
• Sexual dimorphism in locus coeruleus dendritic morphology: a structural basis for sex differences in emotional arousal.
  Bangasser DA, Zhang X, Garachh V, Hanhauser E, Valentino RJ
  Physiol Behav. 2011
  PubMed ID: 21362438
   
  
• High frequency stimulation of the subthalamic nucleus impacts adult neurogenesis in a rat model of Parkinson's disease.
  Khaindrava V, Salin P, Melon C, Ugrumov M, Kerkerian-Le-Goff L, Daszuta A
  Neurobiol Dis. 2011
  PubMed ID: 21296669
   
  
• Alterations in cognitive function and behavioral response to amphetamine induced by prenatal inflammation are dependent on the stage of pregnancy.
  Aguilar-Valles A, Luheshi GN
  Psychoneuroendocrinology. 2011
  PubMed ID: 20934257
   
  
• Doublesex and mab-3-related transcription factor 5 promotes midbrain dopaminergic identity in pluripotent stem cells by enforcing a ventral-medial progenitor fate.
  Gennet N, Gale E, Nan X, Farley E, Takacs K, Oberwallner B, Chambers D, Li M
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21576465
   
  
• Protective effect of resveratrol derived from Polygonum cuspidatum and its liposomal form on nigral cells in Parkinsonian rats.
  Wang Y, Xu H, Fu Q, Ma R, Xiang J
  J Neurol Sci. 2011
  PubMed ID: 21376343
   
  
• Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).
  Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, Kobayashi M, Hirasawa A, Tsujimoto G
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21518883
   
  
• Wnt5a-dopamine D2 receptor interactions regulate dopamine neuron development via extracellular signal-regulated kinase (ERK) activation.
  Yoon S, Choi MH, Chang MS, Baik JH
  J Biol Chem. 2011
  PubMed ID: 21454669
   
  
• Characterisation of a novel model of Parkinson's disease by intra-striatal infusion of the pesticide rotenone.
  Mulcahy P, Walsh S, Paucard A, Rea K, Dowd E
  Neuroscience. 2011
  PubMed ID: 21277943
   
  
• Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing.
  Besse L, Neti M, Anselme I, Gerhardt C, Rüther U, Laclef C, Schneider-Maunoury S
  Development. 2011
  PubMed ID: 21490064
   
  
• α-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator.
  Zhu Y, Duan C, Lü L, Gao H, Zhao C, Yu S, Uéda K, Chan P, Yang H
  Int J Biochem Cell Biol. 2011
  PubMed ID: 21310263
   
  
• Paraventricular nucleus corticotrophin releasing hormone contributes to sympathoexcitation via interaction with neurotransmitters in heart failure.
  Kang YM, Zhang AQ, Zhao XF, Cardinale JP, Elks C, Cao XM, Zhang ZW, Francis J
  Basic Res Cardiol. 2011
  PubMed ID: 21287352
   
  
• Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme.
  Nakashima A, Mori K, Kaneko YS, Hayashi N, Nagatsu T, Ota A
  Biochem Biophys Res Commun. 2011
  PubMed ID: 21392500
   
  
• Pax6 is required at the telencephalic pallial-subpallial boundary for the generation of neuronal diversity in the postnatal limbic system.
  Cocas LA, Georgala PA, Mangin JM, Clegg JM, Kessaris N, Haydar TF, Gallo V, Price DJ, Corbin JG
  J Neurosci. 2011
  PubMed ID: 21471366
   
  
• Increasing proportions of tyrosine hydroxylase-immunoreactive interneurons colocalize with choline acetyltransferase or vasoactive intestinal peptide in the developing rat cerebral cortex.
  Asmus SE, Cocanougher BT, Allen DL, Boone JB, Brooks EA, Hawkins SM, Hench LA, Ijaz T, Mayfield MN
  Brain Res. 2011
  PubMed ID: 21295554
   
  
• Retinoic acid functions as a key GABAergic differentiation signal in the basal ganglia.
  Chatzi C, Brade T, Duester G
  PLoS Biol. 2011
  PubMed ID: 21532733
   
  
• Developmental expression of δ-opioid receptors during maturation of the parasympathetic, sympathetic, and sensory innervations of the neonatal heart: early targets for opioid regulation of autonomic control.
  Mousa SA, Shaqura M, Schäper J, Treskatsch S, Habazettl H, Schäfer M, Abdul-Khaliq H
  J Comp Neurol. 2011
  PubMed ID: 21280046
   
  
• Cholecystokinin and hypothalamic corticotrophin-releasing factor participate in endotoxin-induced hypophagia.
  Rorato R, Reis WL, Antunes-Rodrigues J, Elias LL
  Exp Physiol. 2011
  PubMed ID: 21239462
   
  
• Vascular-dependent effects of elevated glucose on postganglionic sympathetic neurons.
  Damon DH
  Am J Physiol Heart Circ Physiol. 2011
  PubMed ID: 21217063
   
  
• Suppressor of fused is required to maintain the multipotency of neural progenitor cells in the retina.
  Cwinn MA, Mazerolle C, McNeill B, Ringuette R, Thurig S, Hui CC, Wallace VA
  J Neurosci. 2011
  PubMed ID: 21451052
   
  
• Treadmill training improves motor skills and increases tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta in diabetic rats.
  Nascimento PS, Lovatel GA, Barbosa S, Ilha J, Centenaro LA, Malysz T, Xavier LL, Schaan BD, Achaval M
  Brain Res. 2011
  PubMed ID: 21276429
   
  
• Slit2 activity in the migration of guidepost neurons shapes thalamic projections during development and evolution.
  Bielle F, Marcos-Mondejar P, Keita M, Mailhes C, Verney C, Nguyen Ba-Charvet K, Tessier-Lavigne M, Lopez-Bendito G, Garel S
  Neuron. 2011
  PubMed ID: 21435555
   
  
• Cytoprotective effects of growth factors: BDNF more potent than GDNF in an organotypic culture model of Parkinson's disease.
  Stahl K, Mylonakou MN, Skare Ø, Amiry-Moghaddam M, Torp R
  Brain Res. 2011
  PubMed ID: 21236244
   
  
• Photoperiodic suppression of drug reinstatement.
  Sorg BA, Stark G, Sergeeva A, Jansen HT
  Neuroscience. 2011
  PubMed ID: 21185915
   
  
• Multiple coregulatory control of tyrosine hydroxylase gene transcription.
  Reddy SD, Rayala SK, Ohshiro K, Pakala SB, Kobori N, Dash P, Yun S, Qin J, O'Malley BW, Kumar R
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21368136
   
  
• Significant association of TH01 allele 9.3 and SIDS.
  Courts C, Madea B
  J Forensic Sci. 2011
  PubMed ID: 21265843
   
  
• Expression of PINK1 in the brain, eye and ear of mouse during embryonic development.
  d'Amora M, Angelini C, Marcoli M, Cervetto C, Kitada T, Vallarino M
  J Chem Neuroanat. 2011
  PubMed ID: 21126574
   
  
• Activation of different neuronal phenotypes in the rat brain induced by liver ischemia–reperfusion injury: dual Fos/neuropeptide immunohistochemistry.
  Bundzikova J, Pirnik Z, Lackovicova L, Mravec B, Kiss A
  Cell Mol Neurobiol. 2011
  PubMed ID: 21061149
   
  
• Mono-(2-ethylhexyl) phthalate impairs neurodevelopment: inhibition of proliferation and promotion of differentiation in PC12 cells.
  Chen T, Yang W, Li Y, Chen X, Xu S
  Toxicol Lett. 2011
  PubMed ID: 21145954
   
  
• Dopaminergic projections from midbrain to primary motor cortex mediate motor skill learning.
  Hosp JA, Pekanovic A, Rioult-Pedotti MS, Luft AR
  J Neurosci. 2011
  PubMed ID: 21325515
   
  
• Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development.
  Armstrong A, Ryu YK, Chieco D, Kuruvilla R
  J Neurosci. 2011
  PubMed ID: 21325504
   
  
• Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development.
  Kunwar AJ, Rickmann M, Backofen B, Browski SM, Rosenbusch J, Schöning S, Fleischmann T, Krieglstein K, Fischer von Mollard G
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21262811
   
  
• Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity.
  Jeong Y, Dolson DK, Waclaw RR, Matise MP, Sussel L, Campbell K, Kaestner KH, Epstein DJ
  Development. 2011
  PubMed ID: 21205797
   
  
• Neuronal activity regulates expression of tyrosine hydroxylase in adult mouse substantia nigra pars compacta neurons.
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  J Neurochem. 2011
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• Mechanisms involved in the long-term modulation of tyrosine hydroxylase by endothelins in the olfactory bulb of normotensive rats.
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  Neurochem Int. 2011
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• Modulation of sphingosine 1-phosphate and tyrosine hydroxylase in the stress-induced anxiety.
  Jang S, Kim D, Lee Y, Moon S, Oh S
  Neurochem Res. 2011
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• Divergence in enzyme regulation between Caenorhabditis elegans and human tyrosine hydroxylase, the key enzyme in the synthesis of dopamine.
  Calvo AC, Pey AL, Miranda-Vizuete A, Døskeland AP, Martinez A
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• Thalamocortical pathfinding defects precede degeneration of the reticular thalamic nucleus in polysialic acid-deficient mice.
  Schiff M, Röckle I, Burkhardt H, Weinhold B, Hildebrandt H
  J Neurosci. 2011
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• Melatonin attenuates the amphetamine-induced decrease in vesicular monoamine transporter-2 expression in postnatal rat striatum.
  Mukda S, Vimolratana O, Govitrapong P
  Neurosci Lett. 2011
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• Traumatic brain injury reduces striatal tyrosine hydroxylase activity and potassium-evoked dopamine release in rats.
  Shin SS, Bray ER, Zhang CQ, Dixon CE
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• Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus.
  Pelling M, Anthwal N, McNay D, Gradwohl G, Leiter AB, Guillemot F, Ang SL
  Dev Biol. 2011
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• Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6.
  Larder R, Clark DD, Miller NL, Mellon PL
  J Neurosci. 2011
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• Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: behavioral, neurochemical and immunohistochemical studies.
  Khuwaja G, Khan MM, Ishrat T, Ahmad A, Raza SS, Ashafaq M, Javed H, Khan MB, Khan A, Vaibhav K, Safhi MM, Islam F
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• Sim1 is a novel regulator in the differentiation of mouse dorsal raphe serotonergic neurons.
  Osterberg N, Wiehle M, Oehlke O, Heidrich S, Xu C, Fan CM, Krieglstein K, Roussa E
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• Loss of ATF2 function leads to cranial motoneuron degeneration during embryonic mouse development.
  Ackermann J, Ashton G, Lyons S, James D, Hornung JP, Jones N, Breitwieser W
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• Wnt5a regulates midbrain dopaminergic axon growth and guidance.
  Blakely BD, Bye CR, Fernando CV, Horne MK, Macheda ML, Stacker SA, Arenas E, Parish CL
  PLoS One. 2011
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• Sequential generation of olfactory bulb glutamatergic neurons by Neurog2-expressing precursor cells.
  Winpenny E, Lebel-Potter M, Fernandez ME, Brill MS, Götz M, Guillemot F, Raineteau O
  Neural Dev. 2011
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• Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension.
  Rothman RB, Cadet JL, Dersch CM, McCoy MT, Lehrmann E, Becker KG, Bader M, Alenina N, Baumann MH
  PLoS One. 2011
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• Moderate caloric restriction during gestation in rats alters adipose tissue sympathetic innervation and later adiposity in offspring.
  García AP, Palou M, Sánchez J, Priego T, Palou A, Picó C
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• Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis.
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• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
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• Autoantibodies against tyrosine hydroxylase in patients with non-segmental (generalised) vitiligo.
  Kemp EH, Emhemad S, Akhtar S, Watson PF, Gawkrodger DJ, Weetman AP
  Exp Dermatol. 2011
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• Midbrain dopaminergic axons are guided longitudinally through the diencephalon by Slit/Robo signals.
  Dugan JP, Stratton A, Riley HP, Farmer WT, Mastick GS
  Mol Cell Neurosci. 2011
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• Vasopressinergic neurons of the supraoptic nucleus in perinatal rats: reaction to osmotic stimulation and its regulation.
  Abramova MA, Calas A, Ugrumov M
  Brain Struct Funct. 2011
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• Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity.
  Mavromatakis YE, Lin W, Metzakopian E, Ferri AL, Yan CH, Sasaki H, Whisett J, Ang SL
  Mech Dev. 2011
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• Hypobaric hypoxia modulates brain biogenic amines and disturbs sleep architecture.
  Ray K, Dutta A, Panjwani U, Thakur L, Anand JP, Kumar S
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• Transcription factor AP-2β regulates the neurotransmitter phenotype and maturation of chromaffin cells.
  Hong SJ, Huh YH, Leung A, Choi HJ, Ding Y, Kang UJ, Yoo SH, Buettner R, Kim KS
  Mol Cell Neurosci. 2011
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• The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland.
  Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR
  Neurochem Res. 2011
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• Subtypes of medulloblastoma have distinct developmental origins.
  Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang ZJ, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ
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• Human DJ-1-specific transcriptional activation of tyrosine hydroxylase gene.
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  J Biol Chem. 2010
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• Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression.
  Li Z, Caron MG, Blakely RD, Margolis KG, Gershon MD
  J Neurosci. 2010
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• The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain.
  Kanu N, Penicud K, Hristova M, Wong B, Irvine E, Plattner F, Raivich G, Behrens A
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• Effects of Glycyrrhizae Radix on Repeated Restraint Stress-induced Neurochemical and Behavioral Responses.
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  Korean J Physiol Pharmacol. 2010
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• Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation.
  Coppola E, d'Autréaux F, Rijli FM, Brunet JF
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• Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP.
  Di Salvio M, Di Giovannantonio LG, Acampora D, Prosperi R, Omodei D, Prakash N, Wurst W, Simeone A
  Nat Neurosci. 2010
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• Tyrosine hydroxylase polymorphism (C-824T) and hypertension: a population-based study.
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  Am J Hypertens. 2010
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• Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium.
  Sammeta N, Hardin DL, McClintock TS
  Mol Cell Neurosci. 2010
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• MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders.
  Kim AH, Reimers M, Maher B, Williamson V, McMichael O, McClay JL, van den Oord EJ, Riley BP, Kendler KS, Vladimirov VI
  Schizophr Res. 2010
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• Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation.
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  Prostate. 2010
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• Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem.
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  J Neurosci. 2010
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• Expressions and possible roles of GDNF receptors in the developing dopaminergic neurons.
  Cao JP, Li FZ, Zhu YY, Yuan HH, Yu ZQ, Gao DS
  Brain Res Bull. 2010
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• Limited Associations of Dopamine System Genes With Alcohol Dependence and Related Traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD).
  Hack LM, Kalsi G, Aliev F, Kuo PH, Prescott CA, Patterson DG, Walsh D, Dick DM, Riley BP, Kendler KS
  Alcohol Clin Exp Res. 2010
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• VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.
  Lagerström MC, Rogoz K, Abrahamsen B, Persson E, Reinius B, Nordenankar K, Olund C, Smith C, Mendez JA, Chen ZF, Wood JN, Wallén-Mackenzie A, Kullander K
  Neuron. 2010
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• A large-scale candidate gene association study of age at menarche and age at natural menopause.
  He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ
  Hum Genet. 2010
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• Human tyrosine hydroxylase natural allelic variation: influence on autonomic function and hypertension.
  Rao F, Zhang K, Zhang L, Rana BK, Wessel J, Fung MM, Rodriguez-Flores JL, Taupenot L, Ziegler MG, O'Connor DT
  Cell Mol Neurobiol. 2010
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• Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment.
  Gompf HS, Mathai C, Fuller PM, Wood DA, Pedersen NP, Saper CB, Lu J
  J Neurosci. 2010
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• Enlarged lateral ventricles and aberrant behavior in mice overexpressing PDGF-B in embryonic neural stem cells.
  Niklasson M, Bergström T, Zhang XQ, Gustafsdottir SM, Sjögren M, Edqvist PH, Vennström B, Forsberg M, Forsberg-Nilsson K
  Exp Cell Res. 2010
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• Expression pattern of mUBPy in the brain and sensory organs of mouse during embryonic development.
  d'Amora M, Angelini C, Aluigi MG, Marcoli M, Maura G, Berruti G, Vallarino M
  Brain Res. 2010
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• Increased expression of tyrosine hydroxylase in the supraoptic nucleus of the human neonate under hypoxic conditions: a potential neuropathological marker for prolonged perinatal hypoxia.
  Ganou V, Pagida MA, Konstantinidou AE, Malidelis YI, Kontostavlaki DP, Tsekoura E, Patsouris E, Panayotacopoulou MT
  J Neuropathol Exp Neurol. 2010
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• Pet-1 is required across different stages of life to regulate serotonergic function.
  Liu C, Maejima T, Wyler SC, Casadesus G, Herlitze S, Deneris ES
  Nat Neurosci. 2010
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• A rare novel deletion of the tyrosine hydroxylase gene in Parkinson disease.
  Bademci G, Edwards TL, Torres AL, Scott WK, Züchner S, Martin ER, Vance JM, Wang L
  Hum Mutat. 2010
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• Metabotropic glutamate receptors 1 and 5 differentially regulate bulbar dopaminergic cell function.
  Jian K, Cifelli P, Pignatelli A, Frigato E, Belluzzi O
  Brain Res. 2010
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• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
  Diabetes Care. 2010
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• The effects of docosahexaenoic acid on glial derived neurotrophic factor and neurturin in bilateral rat model of Parkinson's disease.
  Tanriover G, Seval-Celik Y, Ozsoy O, Akkoyunlu G, Savcioglu F, Hacioglu G, Demir N, Agar A
  Folia Histochem Cytobiol. 2010
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• Early B-cell factors are required for specifying multiple retinal cell types and subtypes from postmitotic precursors.
  Jin K, Jiang H, Mo Z, Xiang M
  J Neurosci. 2010
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• Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neurons.
  Tilleman H, Hakim V, Novikov O, Liser K, Nashelsky L, Di Salvio M, Krauthammer M, Scheffner O, Maor I, Mayseless O, Meir I, Kayam G, Sela-Donenfeld D, Simeone A, Brodski C
  Mol Cell Neurosci. 2010
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• Differences in tyrosine hydroxylase expression after short-term hypoxia, hypercapnia or hypercapnic hypoxia in rat carotid body.
  Wakai J, Kizaki K, Yamaguchi-Yamada M, Yamamoto Y
  Respir Physiol Neurobiol. 2010
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• Critical roles for the netrin receptor deleted in colorectal cancer in dopaminergic neuronal precursor migration, axon guidance, and axon arborization.
  Xu B, Goldman JS, Rymar VV, Forget C, Lo PS, Bull SJ, Vereker E, Barker PA, Trudeau LE, Sadikot AF, Kennedy TE
  Neuroscience. 2010
  PubMed ID: 20493932
   
  
• The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons.
  Tsarovina K, Reiff T, Stubbusch J, Kurek D, Grosveld FG, Parlato R, Schütz G, Rohrer H
  J Neurosci. 2010
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• Anti-stress effects of ginseng via down-regulation of tyrosine hydroxylase (TH) and dopamine β-hydroxylase (DBH) gene expression in immobilization-stressed rats and PC12 cells.
  Kim Y, Choi EH, Doo M, Kim JY, Kim CJ, Kim CT, Kim IH
  Nutr Res Pract. 2010
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• [Genetic polymorphism in tyrosine hydroxylase gene and essential hypertension in Hunan Han population.].
  Chen L, Chen X, Shi R, Guo Y, Chen A, Bai Y, Chen J, Yang T, Zhang G
  Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010
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• The α2-adrenoceptors do not modify the activity of tyrosine hydroxylase, corticoliberine, and neuropeptide Y producing hypothalamic magnocellular neurons ion the Long Evans and Brattleboro rats.
  Bundzikova J, Pirnik Z, Zelena D, Mikkelsen JD, Kiss A
  J Physiol Pharmacol. 2010
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• Effect of zinc and paraquat co-exposure on neurodegeneration: Modulation of oxidative stress and expression of metallothioneins, toxicant responsive and transporter genes in rats.
  Kumar A, Ahmad I, Shukla S, Singh BK, Patel DK, Pandey HP, Singh C
  Free Radic Res. 2010
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• Interactions between orexin-immunoreactive fibers and adrenaline or noradrenaline-expressing neurons of the lower brainstem in rats and mice.
  Puskás N, Papp RS, Gallatz K, Palkovits M
  Peptides. 2010
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• Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats.
  Perry ML, Leinninger GM, Chen R, Luderman KD, Yang H, Gnegy ME, Myers MG, Kennedy RT
  J Neurochem. 2010
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• Alternating array of tyrosine hydroxylase and heat shock protein 25 immunopositive Purkinje cell stripes in zebrin II-defined transverse zone of the cerebellum of rolling mouse Nagoya.
  Sawada K, Sakata-Haga H, Fukui Y
  Brain Res. 2010
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• Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons.
  Tang M, Villaescusa JC, Luo SX, Guitarte C, Lei S, Miyamoto Y, Taketo MM, Arenas E, Huang EJ
  J Neurosci. 2010
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• Expression of dopamine pathway genes in the midbrain is independent of known ETS transcription factor activity.
  Wang S, Turner EE
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• Fos expression in tyrosine hydroxylase containing hypothalamic neurons in CRH-KO mice: effect of immobilization stress.
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  Endocr Regul. 2010
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• Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
  Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH
  Pharmacogenomics. 2010
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• The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons.
  Chung CY, Licznerski P, Alavian KN, Simeone A, Lin Z, Martin E, Vance J, Isacson O
  Brain. 2010
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• Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes-diencephalic basal plate.
  Moreno-Bravo JA, Perez-Balaguer A, Martinez S, Puelles E
  Dev Dyn. 2010
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• Association study of 182 candidate genes in anorexia nervosa.
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  Am J Med Genet B Neuropsychiatr Genet. 2010
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• Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes.
  Sriram K, Lin GX, Jefferson AM, Roberts JR, Chapman RS, Chen BT, Soukup JM, Ghio AJ, Antonini JM
  Arch Toxicol. 2010
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• Adenosine A(2)A receptor but not HIF-1 mediates Tyrosine hydroxylase induction in hypoxic PC12 cells.
  Gammella E, Cairo G, Tacchini L
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• SOX10 structure-function analysis in the chicken neural tube reveals important insights into its role in human neurocristopathies.
  Cossais F, Wahlbuhl M, Kriesch J, Wegner M
  Hum Mol Genet. 2010
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• Tyrosine hydroxylase deficiency in three Greek patients with a common ancestral mutation.
  Pons R, Serrano M, Ormazabal A, Toma C, Garcia-Cazorla A, Area E, Ribasés M, Kanavakis E, Drakaki K, Giannakopoulos A, Orfanou I, Youroukos S, Cormand B, Artuch R
  Mov Disord. 2010
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• Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.
  Lou H, Montoya SE, Alerte TN, Wang J, Wu J, Peng X, Hong CS, Friedrich EE, Mader SA, Pedersen CJ, Marcus BS, McCormack AL, Di Monte DA, Daubner SC, Perez RG
  J Biol Chem. 2010
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• A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei.
  García-Moreno F, Pedraza M, Di Giovannantonio LG, Di Salvio M, López-Mascaraque L, Simeone A, De Carlos JA
  Nat Neurosci. 2010
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• The basic helix-loop-helix transcription factor Nato3 controls neurogenic activity in mesencephalic floor plate cells.
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  Development. 2010
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• Wnt1-cre-mediated conditional loss of Dicer results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation in mice.
  Huang T, Liu Y, Huang M, Zhao X, Cheng L
  J Mol Cell Biol. 2010
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• Expression by midbrain dopamine neurons of Sema3A and 3F receptors is associated with chemorepulsion in vitro but a mild in vivo phenotype.
  Torre ER, Gutekunst CA, Gross RE
  Mol Cell Neurosci. 2010
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• [Study of follicle-stimulating hormone receptor and tyrosine hydroxylase polymorphisms and pre-eclampsia in Chinese Han population].
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• FoxP1 promotes midbrain identity in embryonic stem cell-derived dopamine neurons by regulating Pitx3.
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• A unique expression pattern of Tbx10 in the hindbrain as revealed by Tbx10(LacZ) allele.
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  Genesis. 2010
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• Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression.
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• Dephosphorylation/inactivation of tyrosine hydroxylase at the median eminence of the hypothalamus is required for suckling-induced prolactin and adrenocorticotrop hormone responses.
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• No association between polymorphism in tyrosine hydroxylase and personality traits in healthy Japanese subjects.
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  Psychiatry Clin Neurosci. 2010
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• Human tyrosine hydroxylase natural genetic variation: delineation of functional transcriptional control motifs disrupted in the proximal promoter.
  Zhang K, Zhang L, Rao F, Brar B, Rodriguez-Flores JL, Taupenot L, O'Connor DT
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• Vulnerability of peripheral catecholaminergic neurons to MPTP is not regulated by alpha-synuclein.
  Cano-Jaimez M, Pérez-Sánchez F, Milán M, Buendía P, Ambrosio S, Fariñas I
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• Biochemical and molecular characterization of tyrosine hydroxylase deficiency in Hong Kong Chinese.
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  Mol Genet Metab. 2010
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• Atrophy of mesenteric sympathetic innervation may contribute to splanchnic vasodilation in rat portal hypertension.
  Coll M, Martell M, Raurell I, Ezkurdia N, Cuenca S, Hernández-Losa J, Esteban R, Guardia J, Bosch J, Genescà J
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• Tyrosine hydroxylase, interleukin-1beta and tumor necrosis factor-alpha are overexpressed in peripheral blood mononuclear cells from schizophrenia patients as determined by semi-quantitative analysis.
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• Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream.
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• Association study between a functional polymorphism of tyrosine hydroxylase gene promoter and personality traits in healthy subjects.
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  Behav Brain Res. 2010
  PubMed ID: 19958792
   
  
• Wnt2 regulates progenitor proliferation in the developing ventral midbrain.
  Sousa KM, Villaescusa JC, Cajanek L, Ondr JK, Castelo-Branco G, Hofstra W, Bryja V, Palmberg C, Bergman T, Wainwright B, Lang RA, Arenas E
  J Biol Chem. 2010
  PubMed ID: 20018874
   
  
• Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system.
  Potzner MR, Tsarovina K, Binder E, Penzo-Méndez A, Lefebvre V, Rohrer H, Wegner M, Sock E
  Development. 2010
  PubMed ID: 20147379
   
  
• Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog.
  Huang CC, Miyagawa S, Matsumaru D, Parker KL, Yao HH
  Endocrinology. 2010
  PubMed ID: 20118198
   
  
• Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon.
  Nakatani T, Kumai M, Mizuhara E, Minaki Y, Ono Y
  Dev Biol. 2010
  PubMed ID: 20035737
   
  
• Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum.
  Guo Q, Li K, Sunmonu NA, Li JY
  Dev Biol. 2010
  PubMed ID: 19968985
   
  
• Association analysis between gene variants of the tyrosine hydroxylase and the serotonin transporter in borderline personality disorder.
  Tadić A, Elsässer A, Storm N, Baade U, Wagner S, Başkaya O, Lieb K, Dahmen N
  World J Biol Psychiatry. 2010
  PubMed ID: 20146650
   
  
• Progesterone decreases tyrosine hydroxylase phosphorylation state and increases protein phosphatase 2A activity in the stalk-median eminence on proestrous afternoon.
  Liu B, Arbogast LA
  J Endocrinol. 2010
  PubMed ID: 19945993
   
  
• Infarction-induced cytokines cause local depletion of tyrosine hydroxylase in cardiac sympathetic nerves.
  Parrish DC, Alston EN, Rohrer H, Nkadi P, Woodward WR, Schütz G, Habecker BA
  Exp Physiol. 2010
  PubMed ID: 19880537
   
  
• Measurement of intrinsic rate constants in the tyrosine hydroxylase reaction.
  Eser BE, Fitzpatrick PF
  Biochemistry. 2010
  PubMed ID: 20025246
   
  
• A biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles.
  Cartier EA, Parra LA, Baust TB, Quiroz M, Salazar G, Faundez V, Egaña L, Torres GE
  J Biol Chem. 2010
  PubMed ID: 19903816
   
  
• Expression of PTPRO in the interneurons of adult mouse olfactory bulb.
  Kotani T, Murata Y, Ohnishi H, Mori M, Kusakari S, Saito Y, Okazawa H, Bixby JL, Matozaki T
  J Comp Neurol. 2010
  PubMed ID: 19924828
   
  
• VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation.
  Birgner C, Nordenankar K, Lundblad M, Mendez JA, Smith C, le Grevès M, Galter D, Olson L, Fredriksson A, Trudeau LE, Kullander K, Wallén-Mackenzie A
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20018672
   
  
• Molecular characterization of the mouse superior lateral parabrachial nucleus through expression of the transcription factor Runx1.
  Zagami CJ, Stifani S
  PLoS One. 2010
  PubMed ID: 21085653
   
  
• Loss of LMO4 in the retina leads to reduction of GABAergic amacrine cells and functional deficits.
  Duquette PM, Zhou X, Yap NL, MacLaren EJ, Lu JJ, Wallace VA, Chen HH
  PLoS One. 2010
  PubMed ID: 20949055
   
  
• Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents.
  Manitt C, Labelle-Dumais C, Eng C, Grant A, Mimee A, Stroh T, Flores C
  PLoS One. 2010
  PubMed ID: 20628609
   
  
• Inactivation of Dicer1 in Steroidogenic factor 1-positive cells reveals tissue-specific requirement for Dicer1 in adrenal, testis, and ovary.
  Huang CC, Yao HH
  BMC Dev Biol. 2010
  PubMed ID: 20540774
   
  
• Polymorphisms of genes for brain-derived neurotrophic factor, methylenetetrahydrofolate reductase, tyrosine hydroxylase, and endothelial nitric oxide synthase in depression and metabolic syndrome.
  Zeman M, Jáchymová M, Jirák R, Vecka M, Tvrzická E, Stanková B, Zák A
  Folia Biol (Praha). 2010
  PubMed ID: 20163778
   
  
• Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology.
  Bedogni F, Hodge RD, Nelson BR, Frederick EA, Shiba N, Daza RA, Hevner RF
  Gene Expr Patterns. 2010
  PubMed ID: 19948250
   
  
• Dynamic expression and heterogeneous intracellular location of En-1 during late mouse embryonic development.
  Zhong SC, Chen XS, Cai QY, Luo X, Chen XH, Liu J, Yao ZX
  Cells Tissues Organs. 2010
  PubMed ID: 19940436
   
  
• Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect.
  Stuebner S, Faus-Kessler T, Fischer T, Wurst W, Prakash N
  Dev Dyn. 2010
  PubMed ID: 19842188
   
  
• Membrane-initiated estradiol signaling increases tyrosine hydroxylase promoter activity with ER alpha in PC12 cells.
  Maharjan S, Serova LI, Sabban EL
  J Neurochem. 2010
  PubMed ID: 19818101
   
  
• Expression of tyrosine hydroxylase increases the resistance of human neuroblastoma cells to oxidative insults.
  Franco JL, Posser T, Gordon SL, Bobrovskaya L, Schneider JJ, Farina M, Dafre AL, Dickson PW, Dunkley PR
  Toxicol Sci. 2010
  PubMed ID: 19815691
   
  
• Delayed dopaminergic neuron differentiation in Lrp6 mutant mice.
  Castelo-Branco G, Andersson ER, Minina E, Sousa KM, Ribeiro D, Kokubu C, Imai K, Prakash N, Wurst W, Arenas E
  Dev Dyn. 2010
  PubMed ID: 19795519
   
  
• Protective effect of ginsenoside against acute renal failure and expression of tyrosine hydroxylase in the locus coeruleus.
  Zhang HA, Wang M, Zhou J, Yao QY, Ma JM, Jiang CL
  Physiol Res. 2010
  PubMed ID: 19249909
   
  
• Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1.
  Rose MF, Ahmad KA, Thaller C, Zoghbi HY
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 20080794
   
  
• Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities.
  Samaco RC, Mandel-Brehm C, Chao HT, Ward CS, Fyffe-Maricich SL, Ren J, Hyland K, Thaller C, Maricich SM, Humphreys P, Greer JJ, Percy A, Glaze DG, Zoghbi HY, Neul JL
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 20007372
   
  
• The dual dopamine-glutamate phenotype of growing mesencephalic neurons regresses in mature rat brain.
  Bérubé-Carrière N, Riad M, Dal Bo G, Lévesque D, Trudeau LE, Descarries L
  J Comp Neurol. 2009
  PubMed ID: 19844994
   
  
• Emx1-lineage progenitors differentially contribute to neural diversity in the striatum and amygdala.
  Cocas LA, Miyoshi G, Carney RS, Sousa VH, Hirata T, Jones KR, Fishell G, Huntsman MM, Corbin JG
  J Neurosci. 2009
  PubMed ID: 20016109
   
  
• Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons.
  Kadkhodaei B, Ito T, Joodmardi E, Mattsson B, Rouillard C, Carta M, Muramatsu S, Sumi-Ichinose C, Nomura T, Metzger D, Chambon P, Lindqvist E, Larsson NG, Olson L, Björklund A, Ichinose H, Perlmann T
  J Neurosci. 2009
  PubMed ID: 20016108
   
  
• Mutant torsinA interacts with tyrosine hydroxylase in cultured cells.
  O'Farrell CA, Martin KL, Hutton M, Delatycki MB, Cookson MR, Lockhart PJ
  Neuroscience. 2009
  PubMed ID: 19761814
   
  
• Differential regulation of human tyrosine hydroxylase isoforms 1 and 2 in situ: Isoform 2 is not phosphorylated at Ser35.
  Gordon SL, Bobrovskaya L, Dunkley PR, Dickson PW
  Biochim Biophys Acta. 2009
  PubMed ID: 19833152
   
  
• Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons.
  Hwang DY, Hong S, Jeong JW, Choi S, Kim H, Kim J, Kim KS
  J Neurochem. 2009
  PubMed ID: 19780901
   
  
• Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin-proteasome system in PC12D cells.
  Kawahata I, Tokuoka H, Parvez H, Ichinose H
  J Neural Transm. 2009
  PubMed ID: 19756365
   
  
• DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina.
  Fuerst PG, Bruce F, Tian M, Wei W, Elstrott J, Feller MB, Erskine L, Singer JH, Burgess RW
  Neuron. 2009
  PubMed ID: 19945391
   
  
• Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons.
  Dubreuil V, Thoby-Brisson M, Rallu M, Persson K, Pattyn A, Birchmeier C, Brunet JF, Fortin G, Goridis C
  J Neurosci. 2009
  PubMed ID: 19940179
   
  
• Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranes.
  Halskau Ø, Ying M, Baumann A, Kleppe R, Rodriguez-Larrea D, Almås B, Haavik J, Martinez A
  J Biol Chem. 2009
  PubMed ID: 19801645
   
  
• Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling.
  Mascarenhas MI, Parker A, Dzierzak E, Ottersbach K
  Blood. 2009
  PubMed ID: 19794138
   
  
• Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis.
  Ferrón SR, Marqués-Torrejón MA, Mira H, Flores I, Taylor K, Blasco MA, Fariñas I
  J Neurosci. 2009
  PubMed ID: 19923274
   
  
• Math1 is essential for the development of hindbrain neurons critical for perinatal breathing.
  Rose MF, Ren J, Ahmad KA, Chao HT, Klisch TJ, Flora A, Greer JJ, Zoghbi HY
  Neuron. 2009
  PubMed ID: 19914183
   
  
• Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.
  Quina LA, Wang S, Ng L, Turner EE
  J Neurosci. 2009
  PubMed ID: 19906978
   
  
• Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking.
  Land BB, Bruchas MR, Schattauer S, Giardino WJ, Aita M, Messinger D, Hnasko TS, Palmiter RD, Chavkin C
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19864633
   
  
• Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools.
  Joksimovic M, Anderegg A, Roy A, Campochiaro L, Yun B, Kittappa R, McKay R, Awatramani R
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19850875
   
  
• Immobilization stress elevates intron-containing transcripts for tyrosine hydroxylase in rat superior cervical ganglia indicating transcriptional activation.
  Cheng SY, Serova LI, Sabban EL
  Stress. 2009
  PubMed ID: 20102321
   
  
• Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
  Am J Hum Genet. 2009
  PubMed ID: 19913121
   
  
• Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers.
  Levin MD, Lu MM, Petrenko NB, Hawkins BJ, Gupta TH, Lang D, Buckley PT, Jochems J, Liu F, Spurney CF, Yuan LJ, Jacobson JT, Brown CB, Huang L, Beermann F, Margulies KB, Madesh M, Eberwine JH, Epstein JA, Patel VV
  J Clin Invest. 2009
  PubMed ID: 19855129
   
  
• BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways.
  Morikawa Y, Zehir A, Maska E, Deng C, Schneider MD, Mishina Y, Cserjesi P
  Development. 2009
  PubMed ID: 19793887
   
  
• The duration of Fgf8 isthmic organizer expression is key to patterning different tectal-isthmo-cerebellum structures.
  Sato T, Joyner AL
  Development. 2009
  PubMed ID: 19793884
   
  
• Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles.
  Wang J, Rahman MF, Duhart HM, Newport GD, Patterson TA, Murdock RC, Hussain SM, Schlager JJ, Ali SF
  Neurotoxicology. 2009
  PubMed ID: 19781568
   
  
• Melatonin attenuates methamphetamine-induced reduction of tyrosine hydroxylase, synaptophysin and growth-associated protein-43 levels in the neonatal rat brain.
  Kaewsuk S, Sae-ung K, Phansuwan-Pujito P, Govitrapong P
  Neurochem Int. 2009
  PubMed ID: 19409439
   
  
• Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1.
  Ishikawa S, Taira T, Niki T, Takahashi-Niki K, Maita C, Maita H, Ariga H, Iguchi-Ariga SM
  J Biol Chem. 2009
  PubMed ID: 19703902
   
  
• Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting.
  Kolk SM, Gunput RA, Tran TS, van den Heuvel DM, Prasad AA, Hellemons AJ, Adolfs Y, Ginty DD, Kolodkin AL, Burbach JP, Smidt MP, Pasterkamp RJ
  J Neurosci. 2009
  PubMed ID: 19812329
   
  
• Psychosocial stress-related changes in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia of adult rats.
  Gavrilovic L, Spasojevic N, Dronjak S
  Auton Neurosci. 2009
  PubMed ID: 19482560
   
  
• Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.
  Sacchetti P, Sousa KM, Hall AC, Liste I, Steffensen KR, Theofilopoulos S, Parish CL, Hazenberg C, Richter LA, Hovatta O, Gustafsson JA, Arenas E
  Cell Stem Cell. 2009
  PubMed ID: 19796621
   
  
• Catalponol enhances dopamine biosynthesis and protects against L-DOPA-induced cytotoxicity in PC12 cells.
  Huang HS, Han XH, Hwang BY, Park JI, Yoo SK, Choi HS, Lim SC, Lee MK
  J Asian Nat Prod Res. 2009
  PubMed ID: 20183248
   
  
• Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
  Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, Muir K, Hopper JL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL, Stanford JL, Ostrander EA, Ingles SA, John EM, Thibodeau SN, Schaid D, Park JY, Spurdle A, Clements J, Dickinson JL, Maier C, Vogel W, Dörk T, Rebbeck TR, Cooney KA, Cannon-Albright L, Chappuis PO, Hutter P, Zeegers M, Kaneva R, Zhang HW, Lu YJ, Foulkes WD, English DR, Leongamornlert DA, Tymrakiewicz M, Morrison J, Ardern-Jones AT, Hall AL, O'Brien LT, Wilkinson RA, Saunders EJ, Page EC, Sawyer EJ, Edwards SM, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Southey MC, Lophatananon A, Liu JF, Kolonel LN, Le Marchand L, Wahlfors T, Tammela TL, Auvinen A, Lewis SJ, Cox A, FitzGerald LM, Koopmeiners JS, Karyadi DM, Kwon EM, Stern MC, Corral R, Joshi AD, Shahabi A, McDonnell SK, Sellers TA, Pow-Sang J, Chambers S, Aitken J, Gardiner RA, Batra J, Kedda MA, Lose F, Polanowski A, Patterson B, Serth J, Meyer A, Luedeke M, Stefflova K, Ray AM, Lange EM, Farnham J, Khan H, Slavov C, Mitkova A, Cao G, UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, UK ProtecT Study Collaborators, PRACTICAL Consortium, Easton DF
  Nat Genet. 2009
  PubMed ID: 19767753
   
  
• Abnormal retinal development in the Btrc null mouse.
  Baguma-Nibasheka M, Kablar B
  Dev Dyn. 2009
  PubMed ID: 19705444
   
  
• Patterning of ventral telencephalon requires positive function of Gli transcription factors.
  Yu W, Wang Y, McDonnell K, Stephen D, Bai CB
  Dev Biol. 2009
  PubMed ID: 19632216
   
  
• Periphilin is strongly expressed in the murine nervous system and is indispensable for murine development.
  Soehn AS, Pham TT, Schaeferhoff K, Floss T, Weisenhorn DM, Wurst W, Bonin M, Riess O
  Genesis. 2009
  PubMed ID: 19621438
   
  
• Misexpression of Gbx2 throughout the mesencephalon by a conditional gain-of-function transgene leads to deletion of the midbrain and cerebellum in mice.
  Sunmonu NA, Chen L, Li JY
  Genesis. 2009
  PubMed ID: 19603509
   
  
• Expression of ephrinA5 during development and potential involvement in the guidance of the mesostriatal pathway.
  Deschamps C, Faideau M, Jaber M, Gaillard A, Prestoz L
  Exp Neurol. 2009
  PubMed ID: 19576892
   
  
• In vivo role for CREB signaling in the noradrenergic differentiation of sympathetic neurons.
  Rüdiger R, Binder E, Tsarovina K, Schmidt M, Reiff T, Stubbusch J, Rohrer H
  Mol Cell Neurosci. 2009
  PubMed ID: 19545628
   
  
• The low affinity dopamine binding site on tyrosine hydroxylase: the role of the N-terminus and in situ regulation of enzyme activity.
  Gordon SL, Webb JK, Shehadeh J, Dunkley PR, Dickson PW
  Neurochem Res. 2009
  PubMed ID: 19448984
   
  
• Decreased expression of ErbB4 and tyrosine hydroxylase mRNA and protein in the ventral midbrain of aged rats.
  Dickerson JW, Hemmerle AM, Numan S, Lundgren KH, Seroogy KB
  Neuroscience. 2009
  PubMed ID: 19505538
   
  
• Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development.
  Lin W, Metzakopian E, Mavromatakis YE, Gao N, Balaskas N, Sasaki H, Briscoe J, Whitsett JA, Goulding M, Kaestner KH, Ang SL
  Dev Biol. 2009
  PubMed ID: 19607821
   
  
• Dopamine is necessary for cue-dependent fear conditioning.
  Fadok JP, Dickerson TM, Palmiter RD
  J Neurosci. 2009
  PubMed ID: 19741115
   
  
• Association between Antipsychotics-Induced Restless Legs Syndrome and Tyrosine Hydroxylase Gene Polymorphism.
  Cho CH, Kang SG, Choi JE, Park YM, Lee HJ, Kim L
  Psychiatry Investig. 2009
  PubMed ID: 20046397
   
  
• IGF-I promotes neuronal migration and positioning in the olfactory bulb and the exit of neuroblasts from the subventricular zone.
  Hurtado-Chong A, Yusta-Boyo MJ, Vergaño-Vera E, Bulfone A, de Pablo F, Vicario-Abejón C
  Eur J Neurosci. 2009
  PubMed ID: 19712103
   
  
• NCAM and polysialyltransferase profiles match dopaminergic marker gene expression but polysialic acid is dispensable for development of the midbrain dopamine system.
  Schiff M, Weinhold B, Grothe C, Hildebrandt H
  J Neurochem. 2009
  PubMed ID: 19619134
   
  
• Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons.
  Ulusoy A, Sahin G, Björklund T, Aebischer P, Kirik D
  Mol Ther. 2009
  PubMed ID: 19584816
   
  
• Targeted disruption of Sonic Hedgehog in the mouse adrenal leads to adrenocortical hypoplasia.
  Ching S, Vilain E
  Genesis. 2009
  PubMed ID: 19536807
   
  
• Spatiotemporal expression in mouse brain of Kiaa2022, a gene disrupted in two patients with severe mental retardation.
  Cantagrel V, Haddad MR, Ciofi P, Andrieu D, Lossi AM, Maldergem L, Roux JC, Villard L
  Gene Expr Patterns. 2009
  PubMed ID: 19524067
   
  
• Effects of prodynorphin deletion on striatal dopamine in mice during normal aging and in response to MPTP.
  Nguyen XV, Liu M, Kim HC, Bing G
  Exp Neurol. 2009
  PubMed ID: 19500577
   
  
• Profound changes in dopaminergic neurotransmission in the prefrontal cortex in response to flattening of the diurnal glucocorticoid rhythm: implications for bipolar disorder.
  Minton GO, Young AH, McQuade R, Fairchild G, Ingram CD, Gartside SE
  Neuropsychopharmacology. 2009
  PubMed ID: 19494803
   
  
• ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells.
  Obara Y, Yamauchi A, Takehara S, Nemoto W, Takahashi M, Stork PJ, Nakahata N
  J Biol Chem. 2009
  PubMed ID: 19581298
   
  
• Restriction of dopamine signaling to the dorsolateral striatum is sufficient for many cognitive behaviors.
  Darvas M, Palmiter RD
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19667174
   
  
• Subtype specification of GABAergic amacrine cells by the orphan nuclear receptor Nr4a2/Nurr1.
  Jiang H, Xiang M
  J Neurosci. 2009
  PubMed ID: 19692620
   
  
• Stress-induced activity in the locus coeruleus is not sensitive to stressor controllability.
  McDevitt RA, Szot P, Baratta MV, Bland ST, White SS, Maier SF, Neumaier JF
  Brain Res. 2009
  PubMed ID: 19524553
   
  
• Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain.
  Prakash N, Puelles E, Freude K, Trümbach D, Omodei D, Di Salvio M, Sussel L, Ericson J, Sander M, Simeone A, Wurst W
  Development. 2009
  PubMed ID: 19592574
   
  
• Two types of tyrosine hydroxylase positive GABAergic juxtaglomerular neurons in the mouse main olfactory bulb are different in their time of origin.
  Kosaka T, Kosaka K
  Neurosci Res. 2009
  PubMed ID: 19445978
   
  
• Novel markers reveal subpopulations of subplate neurons in the murine cerebral cortex.
  Hoerder-Suabedissen A, Wang WZ, Lee S, Davies KE, Goffinet AM, Rakić S, Parnavelas J, Reim K, Nicolić M, Paulsen O, Molnár Z
  Cereb Cortex. 2009
  PubMed ID: 19008461
   
  
• Examination of tetrahydrobiopterin pathway genes in autism.
  Schnetz-Boutaud NC, Anderson BM, Brown KD, Wright HH, Abramson RK, Cuccaro ML, Gilbert JR, Pericak-Vance MA, Haines JL
  Genes Brain Behav. 2009
  PubMed ID: 19674121
   
  
• The neuronal nitric oxide synthase (nNOS) gene contributes to the regulation of tyrosine hydroxylase (TH) by cocaine.
  Balda MA, Anderson KL, Itzhak Y
  Neurosci Lett. 2009
  PubMed ID: 19429176
   
  
• Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.
  O'Doherty C, Favorov A, Heggarty S, Graham C, Favorova O, Ochs M, Hawkins S, Hutchinson M, O'Rourke K, Vandenbroeck K
  Pharmacogenomics. 2009
  PubMed ID: 19604093
   
  
• Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain.
  Jacob J, Storm R, Castro DS, Milton C, Pla P, Guillemot F, Birchmeier C, Briscoe J
  Development. 2009
  PubMed ID: 19542360
   
  
• Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons.
  Jacobs FM, van der Linden AJ, Wang Y, von Oerthel L, Sul HS, Burbach JP, Smidt MP
  Development. 2009
  PubMed ID: 19515692
   
  
• Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia.
  Clot F, Grabli D, Cazeneuve C, Roze E, Castelnau P, Chabrol B, Landrieu P, Nguyen K, Ponsot G, Abada M, Doummar D, Damier P, Gil R, Thobois S, Ward AJ, Hutchinson M, Toutain A, Picard F, Camuzat A, Fedirko E, Sân C, Bouteiller D, LeGuern E, Durr A, Vidailhet M, Brice A, French Dystonia Network
  Brain. 2009
  PubMed ID: 19491146
   
  
• Tyrosine hydroxylase phosphorylation after naloxone-induced morphine withdrawal in the left ventricle.
  Almela P, Victoria Milanés M, Luisa Laorden M
  Basic Res Cardiol. 2009
  PubMed ID: 19104749
   
  
• In situ hybridization reveals developmental regulation of ErbB1-4 mRNA expression in mouse midbrain: implication of ErbB receptors for dopaminergic neurons.
  Abe Y, Namba H, Zheng Y, Nawa H
  Neuroscience. 2009
  PubMed ID: 19298847
   
  
• Multiple lineage-specific roles of Smad4 during neural crest development.
  Büchmann-Møller S, Miescher I, John N, Krishnan J, Deng CX, Sommer L
  Dev Biol. 2009
  PubMed ID: 19361496
   
  
• Wnt5a mediates nerve growth factor-dependent axonal branching and growth in developing sympathetic neurons.
  Bodmer D, Levine-Wilkinson S, Richmond A, Hirsh S, Kuruvilla R
  J Neurosci. 2009
  PubMed ID: 19515925
   
  
• Spectroscopy and kinetics of wild-type and mutant tyrosine hydroxylase: mechanistic insight into O2 activation.
  Chow MS, Eser BE, Wilson SA, Hodgson KO, Hedman B, Fitzpatrick PF, Solomon EI
  J Am Chem Soc. 2009
  PubMed ID: 19489646
   
  
• Identification by hydrogen/deuterium exchange of structural changes in tyrosine hydroxylase associated with regulation.
  Wang S, Sura GR, Dangott LJ, Fitzpatrick PF
  Biochemistry. 2009
  PubMed ID: 19371093
   
  
• Tyrosine hydroxylase Val81Met polymorphism: lack of association with schizophrenia.
  Andreou D, Saetre P, Lundmark P, Hansen T, Timm S, Melle I, Djurovic S, Andreassen OA, Werge T, Hall H, Agartz I, Terenius L, Jönsson EG
  Psychiatr Genet. 2009
  PubMed ID: 19491717
   
  
• Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons.
  Tang M, Miyamoto Y, Huang EJ
  Development. 2009
  PubMed ID: 19439492
   
  
• Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A.
  Elia J, Capasso M, Zaheer Z, Lantieri F, Ambrosini P, Berrettini W, Devoto M, Hakonarson H
  Psychiatr Genet. 2009
  PubMed ID: 19352218
   
  
• Defects in neural stem cell proliferation and olfaction in Chd7 deficient mice indicate a mechanism for hyposmia in human CHARGE syndrome.
  Layman WS, McEwen DP, Beyer LA, Lalani SR, Fernbach SD, Oh E, Swaroop A, Hegg CC, Raphael Y, Martens JR, Martin DM
  Hum Mol Genet. 2009
  PubMed ID: 19279158
   
  
• Effects of scoparone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells.
  Yang YJ, Lee HJ, Huang HS, Lee BK, Choi HS, Lim SC, Lee CK, Lee MK
  J Neurosci Res. 2009
  PubMed ID: 19185027
   
  
• Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning.
  Tsai HC, Zhang F, Adamantidis A, Stuber GD, Bonci A, de Lecea L, Deisseroth K
  Science. 2009
  PubMed ID: 19389999
   
  
• 14-3-3zeta contributes to tyrosine hydroxylase activity in MN9D cells: localization of dopamine regulatory proteins to mitochondria.
  Wang J, Lou H, Pedersen CJ, Smith AD, Perez RG
  J Biol Chem. 2009
  PubMed ID: 19289463
   
  
• The bHLH transcription factor Hand2 is essential for the maintenance of noradrenergic properties in differentiated sympathetic neurons.
  Schmidt M, Lin S, Pape M, Ernsberger U, Stanke M, Kobayashi K, Howard MJ, Rohrer H
  Dev Biol. 2009
  PubMed ID: 19254708
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells.
  Friling S, Andersson E, Thompson LH, Jönsson ME, Hebsgaard JB, Nanou E, Alekseenko Z, Marklund U, Kjellander S, Volakakis N, Hovatta O, El Manira A, Björklund A, Perlmann T, Ericson J
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19383789
   
  
• Shh dependent and independent maintenance of basal midbrain.
  Perez-Balaguer A, Puelles E, Wurst W, Martinez S
  Mech Dev. 2009
  PubMed ID: 19298856
   
  
• High-fat diet decreases tyrosine hydroxylase mRNA expression irrespective of obesity susceptibility in mice.
  Li Y, South T, Han M, Chen J, Wang R, Huang XF
  Brain Res. 2009
  PubMed ID: 19285041
   
  
• Infantile hypokinetic-hypotonic syndrome due to two novel mutations of the tyrosine hydroxylase gene.
  Doummar D, Clot F, Vidailhet M, Afenjar A, Durr A, Brice A, Mignot C, Guet A, de Villemeur TB, Rodriguez D
  Mov Disord. 2009
  PubMed ID: 19224593
   
  
• Gene regulatory logic of dopamine neuron differentiation.
  Flames N, Hobert O
  Nature. 2009
  PubMed ID: 19287374
   
  
• Human longevity and 11p15.5: a study in 1321 centenarians.
  Lescai F, Blanché H, Nebel A, Beekman M, Sahbatou M, Flachsbart F, Slagboom E, Schreiber S, Sorbi S, Passarino G, Franceschi C
  Eur J Hum Genet. 2009
  PubMed ID: 19367319
   
  
• SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a.
  Kim MJ, Ahn K, Park SH, Kang HJ, Jang BG, Oh SJ, Oh SM, Jeong YJ, Heo JI, Suh JG, Lim SS, Ko YJ, Huh SO, Kim SC, Park JB, Kim J, Kim JI, Jo SA, Lee JY
  FEBS Lett. 2009
  PubMed ID: 19285077
   
  
• Expression of EGR-1 in a subset of olfactory bulb dopaminergic cells.
  Akiba N, Jo S, Akiba Y, Baker H, Cave JW
  J Mol Histol. 2009
  PubMed ID: 19387849
   
  
• Catecholaminergic systems in stress: structural and molecular genetic approaches.
  Kvetnansky R, Sabban EL, Palkovits M
  Physiol Rev. 2009
  PubMed ID: 19342614
   
  
• FGF8 signaling regulates growth of midbrain dopaminergic axons by inducing semaphorin 3F.
  Yamauchi K, Mizushima S, Tamada A, Yamamoto N, Takashima S, Murakami F
  J Neurosci. 2009
  PubMed ID: 19339600
   
  
• Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome.
  Medina CF, Mazerolle C, Wang Y, Bérubé NG, Coupland S, Gibbons RJ, Wallace VA, Picketts DJ
  Hum Mol Genet. 2009
  PubMed ID: 19088125
   
  
• Identification of an activator protein-1-like sequence as the glucocorticoid response element in the rat tyrosine hydroxylase gene.
  Rani CS, Elango N, Wang SS, Kobayashi K, Strong R
  Mol Pharmacol. 2009
  PubMed ID: 19060113
   
  
• The EGFR is required for proper innervation to the skin.
  Maklad A, Nicolai JR, Bichsel KJ, Evenson JE, Lee TC, Threadgill DW, Hansen LA
  J Invest Dermatol. 2009
  PubMed ID: 18830272
   
  
• Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice.
  Yoshida M, Takayanagi Y, Inoue K, Kimura T, Young LJ, Onaka T, Nishimori K
  J Neurosci. 2009
  PubMed ID: 19228979
   
  
• Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression.
  Jacobs FM, van Erp S, van der Linden AJ, von Oerthel L, Burbach JP, Smidt MP
  Development. 2009
  PubMed ID: 19144721
   
  
• Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis.
  Joksimovic M, Yun BA, Kittappa R, Anderegg AM, Chang WW, Taketo MM, McKay RD, Awatramani RB
  Nat Neurosci. 2009
  PubMed ID: 19122665
   
  
• Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation.
  Kao SC, Wu H, Xie J, Chang CP, Ranish JA, Graef IA, Crabtree GR
  Science. 2009
  PubMed ID: 19179536
   
  
• Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
  Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB
  Eur J Hum Genet. 2009
  PubMed ID: 19156168
   
  
• Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB(1) cannabinoid receptor agonists on tyrosine hydroxylase expression.
  Bosier B, Hermans E, Lambert DM
  Biochem Pharmacol. 2009
  PubMed ID: 18992715
   
  
• Aging reveals a role for nigral tyrosine hydroxylase ser31 phosphorylation in locomotor activity generation.
  Salvatore MF, Pruett BS, Spann SL, Dempsey C
  PLoS One. 2009
  PubMed ID: 20037632
   
  
• New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling.
  Badea TC, Hua ZL, Smallwood PM, Williams J, Rotolo T, Ye X, Nathans J
  PLoS One. 2009
  PubMed ID: 19924248
   
  
• Genetical genomic determinants of alcohol consumption in rats and humans.
  Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL, WHO/ISBRA Study on State and Trait Markers of Alcoholism
  BMC Biol. 2009
  PubMed ID: 19874574
   
  
• Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons.
  Hammond R, Blaess S, Abeliovich A
  PLoS One. 2009
  PubMed ID: 19774071
   
  
• Two-stage case-control association study of dopamine-related genes and migraine.
  Corominas R, Ribases M, Camiña M, Cuenca-León E, Pardo J, Boronat S, Sobrido MJ, Cormand B, Macaya A
  BMC Med Genet. 2009
  PubMed ID: 19772578
   
  
• Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
  Roe BE, Tilley MR, Gu HH, Beversdorf DQ, Sadee W, Haab TC, Papp AC
  PLoS One. 2009
  PubMed ID: 19693267
   
  
• Effect of dioxins on regulation of tyrosine hydroxylase gene expression by aryl hydrocarbon receptor: a neurotoxicology study.
  Akahoshi E, Yoshimura S, Uruno S, Ishihara-Sugano M
  Environ Health. 2009
  PubMed ID: 19500377
   
  
• Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression.
  Alavian KN, Sgadò P, Alberi L, Subramaniam S, Simon HH
  Neural Dev. 2009
  PubMed ID: 19291307
   
  
• Tyrosine hydroxylase and DOPA decarboxylase gene variants in personality traits.
  Giegling I, Moreno-De-Luca D, Calati R, Hartmann AM, Möller HJ, De Ronchi D, Rujescu D, Serretti A
  Neuropsychobiology. 2009
  PubMed ID: 19221445
   
  
• Molecular implications of repeated aggression: Th, Dat1, Snca and Bdnf gene expression in the VTA of victorious male mice.
  Bondar NP, Boyarskikh UA, Kovalenko IL, Filipenko ML, Kudryavtseva NN
  PLoS One. 2009
  PubMed ID: 19142237
   
  
• Minimal residual disease in peripheral blood stem cell harvests from high-risk neuroblastoma patients.
  Avigad S, Feinberg-Gorenshtein G, Luria D, Jeison M, Stein J, Grunshpan A, Sverdlov Y, Ash S, Yaniv I
  J Pediatr Hematol Oncol. 2009
  PubMed ID: 19125082
   
  
• Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons.
  Kala K, Haugas M, Lilleväli K, Guimera J, Wurst W, Salminen M, Partanen J
  Development. 2009
  PubMed ID: 19088086
   
  
• Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects.
  Zhang Y, Singh MK, Degenhardt KR, Lu MM, Bennett J, Yoshida Y, Epstein JA
  Dev Biol. 2009
  PubMed ID: 18992737
   
  
• Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons.
  Guo C, Qiu HY, Shi M, Huang Y, Johnson RL, Rubinstein M, Chen SD, Ding YQ
  J Neurosci. 2008
  PubMed ID: 19109492
   
  
• mRNAs of tyrosine hydroxylase and dopa decarboxylase but not of GD2 synthase are specific for neuroblastoma minimal disease and predicts outcome for children with high-risk disease when measured at diagnosis.
  Träger C, Vernby A, Kullman A, Ora I, Kogner P, Kågedal B
  Int J Cancer. 2008
  PubMed ID: 18814238
   
  
• Examination of association to autism of common genetic variationin genes related to dopamine.
  Anderson BM, Schnetz-Boutaud N, Bartlett J, Wright HH, Abramson RK, Cuccaro ML, Gilbert JR, Pericak-Vance MA, Haines JL
  Autism Res. 2008
  PubMed ID: 19360691
   
  
• Impaired chronotropic response to exercise in mice lacking catecholamines in adrenergic cells.
  Bao X, Liu F, Gu Y, Lu CM, Ziegler MG
  Ann N Y Acad Sci. 2008
  PubMed ID: 19120121
   
  
• Adrenergic polymorphism and the human stress response.
  Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork NJ, Taupenot L, Ziegler MG, O'Connor DT
  Ann N Y Acad Sci. 2008
  PubMed ID: 19120120
   
  
• Stress-induced changes in tyrosine hydroxylase gene expression in rat hypothalamic paraventricular, periventricular, and dorsomedial nuclei.
  Kiss A, Mravec B, Palkovits M, Kvetnanský R
  Ann N Y Acad Sci. 2008
  PubMed ID: 19120093
   
  
• Chronic isolation of adult rats decreases gene expression of catecholamine biosynthetic enzymes in adrenal medulla.
  Gavrilovic L, Spasojevic N, Tanic N, Dronjak S
  Neuro Endocrinol Lett. 2008
  PubMed ID: 19112418
   
  
• TGIF, a homeodomain transcription factor, regulates retinal progenitor cell differentiation.
  Satoh S, Watanabe S
  Exp Eye Res. 2008
  PubMed ID: 18926818
   
  
• Dopaminergic system dysregulation in the mrsk2_KO mouse, an animal model of the Coffin-Lowry syndrome.
  Marques Pereira P, Gruss M, Braun K, Foos N, Pannetier S, Hanauer A
  J Neurochem. 2008
  PubMed ID: 18823370
   
  
• DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brain.
  Shi M, Guo C, Dai JX, Ding YQ
  Mol Cell Neurosci. 2008
  PubMed ID: 18771734
   
  
• Tyrosine hydroxylase immunoreactivity in the locus coeruleus is elevated in violent suicidal depressive patients.
  Gos T, Krell D, Bielau H, Brisch R, Trübner K, Steiner J, Bernstein HG, Jankowski Z, Bogerts B
  Eur Arch Psychiatry Clin Neurosci. 2008
  PubMed ID: 18574609
   
  
• Fine structural survey of tyrosine hydroxylase immunoreactive terminals in the myenteric ganglion of the rat duodenum.
  Hayakawa T, Kuwahara S, Maeda S, Tanaka K, Seki M
  J Chem Neuroanat. 2008
  PubMed ID: 18572382
   
  
• Molecular analyses of GCH-1, TH and parkin genes in Chinese dopa-responsive dystonia families.
  Wu ZY, Lin Y, Chen WJ, Zhao GX, Xie H, Murong SX, Wang N
  Clin Genet. 2008
  PubMed ID: 18554280
   
  
• Expression levels of mRNAs for catecholamine biosynthetic enzymes as markers of acute response to contusion stress during the early postmortem period.
  Takahashi S
  Tohoku J Exp Med. 2008
  PubMed ID: 18987458
   
  
• Rat mesenchymal stem cells increase tyrosine hydroxylase expression and dopamine content in ventral mesencephalic cells in vitro.
  Jin GZ, Cho SJ, Choi EG, Lee YS, Yu XF, Choi KS, Yee ST, Jeon JT, Kim MO, Kong IK
  Cell Biol Int. 2008
  PubMed ID: 18778785
   
  
• Tyrosine hydroxylase expression and Cdk5 kinase activity in ataxic cerebellum.
  Cheung KJ, Rosales JL, Lee BC, Jeong YG, Lee KY
  Mol Cell Biochem. 2008
  PubMed ID: 18618229
   
  
• Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants.
  Sakae N, Yamasaki N, Kitaichi K, Fukuda T, Yamada M, Yoshikawa H, Hiranita T, Tatsumi Y, Kira J, Yamamoto T, Miyakawa T, Nakayama KI
  Hum Mol Genet. 2008
  PubMed ID: 18647754
   
  
• [The association of tyrosine hydroxylase gene polymorphism with mental disorder]
  Yu J, Pang H, Wang BJ
  Fa Yi Xue Za Zhi. 2008
  PubMed ID: 18979915
   
  
• Control of precerebellar neuron development by Olig3 bHLH transcription factor.
  Liu Z, Li H, Hu X, Yu L, Liu H, Han R, Colella R, Mower GD, Chen Y, Qiu M
  J Neurosci. 2008
  PubMed ID: 18829970
   
  
• Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon.
  Omodei D, Acampora D, Mancuso P, Prakash N, Di Giovannantonio LG, Wurst W, Simeone A
  Development. 2008
  PubMed ID: 18820178
   
  
• Oestrogen receptor beta contributes to the transient sex difference in tyrosine hydroxylase expression in the mouse locus coeruleus.
  Pendergast JS, Tuesta LM, Bethea JR
  J Neuroendocrinol. 2008
  PubMed ID: 18680559
   
  
• Development of satellite glia in mouse sympathetic ganglia: GDNF and GFRalpha1 are not essential.
  Callahan T, Young HM, Anderson RB, Enomoto H, Anderson CR
  Glia. 2008
  PubMed ID: 18551627
   
  
• Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities.
  Katayama K, Yamada K, Ornthanalai VG, Inoue T, Ota M, Murphy NP, Aruga J
  Mol Psychiatry. 2008
  PubMed ID: 18794888
   
  
• MPTP-induced Parkinsonism is associated with damage to Leydig cells and testosterone loss.
  Ruffoli R, Giambelluca MA, Scavuzzo MC, Pasquali L, Giannessi F, Fornai F
  Brain Res. 2008
  PubMed ID: 18644355
   
  
• Induction of dopamine biosynthesis by l-DOPA in PC12 cells: implications of L-DOPA influx and cyclic AMP.
  Jin CM, Yang YJ, Huang HS, Lim SC, Kai M, Lee MK
  Eur J Pharmacol. 2008
  PubMed ID: 18602388
   
  
• Abnormal sympathetic nervous system development and physiological dysautonomia in Egr3-deficient mice.
  Eldredge LC, Gao XM, Quach DH, Li L, Han X, Lomasney J, Tourtellotte WG
  Development. 2008
  PubMed ID: 18653557
   
  
• High oxygen prevents fetal lethality due to lack of catecholamines.
  Ream MA, Chandra R, Peavey M, Ray AM, Roffler-Tarlov S, Kim HG, Wetsel WC, Rockman HA, Chikaraishi DM
  Am J Physiol Regul Integr Comp Physiol. 2008
  PubMed ID: 18635452
   
  
• The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts.
  Almela P, Milanés M, Laorden M
  Br J Pharmacol. 2008
  PubMed ID: 18536752
   
  
• Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia.
  Sato K, Sumi-Ichinose C, Kaji R, Ikemoto K, Nomura T, Nagatsu I, Ichinose H, Ito M, Sako W, Nagahiro S, Graybiel AM, Goto S
  Proc Natl Acad Sci U S A. 2008
  PubMed ID: 18713855
   
  
• Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.
  Bedford L, Hay D, Devoy A, Paine S, Powe DG, Seth R, Gray T, Topham I, Fone K, Rezvani N, Mee M, Soane T, Layfield R, Sheppard PW, Ebendal T, Usoskin D, Lowe J, Mayer RJ
  J Neurosci. 2008
  PubMed ID: 18701681
   
  
• Effect of the co-administration of vitamin C and vitamin E on tyrosine hydroxylase and Nurr1 expression in the prenatal rat ventral mesencephalon.
  Lee HY, Naha N, Ullah N, Jin GZ, Kong IK, Koh PO, Seong HH, Kim MO
  J Vet Med Sci. 2008
  PubMed ID: 18772553
   
  
• Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex.
  Kim AC, Reuter AL, Zubair M, Else T, Serecky K, Bingham NC, Lavery GG, Parker KL, Hammer GD
  Development. 2008
  PubMed ID: 18599507
   
  
• A functional polymorphism in the tyrosine hydroxylase gene indicates a role of noradrenalinergic signaling in sudden infant death syndrome.
  Klintschar M, Reichenpfader B, Saternus KS
  J Pediatr. 2008
  PubMed ID: 18534229
   
  
• Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches.
  Yoon MJ, Koo BK, Song R, Jeong HW, Shin J, Kim YW, Kong YY, Suh PG
  Mol Cell Biol. 2008
  PubMed ID: 18505817
   
  
• Neurochemical characterization of tyrosine hydroxylase-immunoreactive interneurons in the developing rat cerebral cortex.
  Asmus SE, Anderson EK, Ball MW, Barnes BA, Bohnen AM, Brown AM, Hartley LJ, Lally MC, Lundblad TM, Martin JB, Moss BD, Phelps KD, Phillips LR, Quilligan CG, Steed RB, Terrell SL, Warner AE
  Brain Res. 2008
  PubMed ID: 18589406
   
  
• Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons.
  Hendershot TJ, Liu H, Clouthier DE, Shepherd IT, Coppola E, Studer M, Firulli AB, Pittman DL, Howard MJ
  Dev Biol. 2008
  PubMed ID: 18501887
   
  
• Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease.
  Alves S, Régulier E, Nascimento-Ferreira I, Hassig R, Dufour N, Koeppen A, Carvalho AL, Simões S, de Lima MC, Brouillet E, Gould VC, Déglon N, de Almeida LP
  Hum Mol Genet. 2008
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• [Association of the tyrosine hydroxylase gene polymorphism with schizophrenia in the population of central Poland]
  Jacewicz R, Gałecki P, Florkowski A, Berent J
  Psychiatr Pol. 2008
  PubMed ID: 19189602
   
  
• Effects of asimilobine on dopamine biosynthesis and l-DOPA-induced cytotoxicity in PC12 cells.
  Jin CM, Lee JJ, Kim YK, Ryu SY, Lim SC, Hwang BY, Lee CK, Lee MK
  J Asian Nat Prod Res. 2008
  PubMed ID: 18696327
   
  
• Generation and characterization of a Gdf1 conditional null allele.
  Bengtsson H, Epifantseva I, Abrink M, Kylberg A, Kullander K, Ebendal T, Usoskin D
  Genesis. 2008
  PubMed ID: 18615710
   
  
• Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
  Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L
  Nat Genet. 2008
  PubMed ID: 18583979
   
  
• Loss of the Prader-Willi syndrome protein necdin causes defective migration, axonal outgrowth, and survival of embryonic sympathetic neurons.
  Tennese AA, Gee CB, Wevrick R
  Dev Dyn. 2008
  PubMed ID: 18570257
   
  
• Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension.
  Coll M, Genescà J, Raurell I, Rodríguez-Vilarrupla A, Mejías M, Otero T, Oria M, Esteban R, Guardia J, Bosch J, Martell M
  J Hepatol. 2008
  PubMed ID: 18457899
   
  
• Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb.
  Harrison SJ, Nishinakamura R, Monaghan AP
  Cereb Cortex. 2008
  PubMed ID: 18024993
   
  
• Preliminary evidence for a modulation of fetal dopaminergic development by maternal immune activation during pregnancy.
  Meyer U, Engler A, Weber L, Schedlowski M, Feldon J
  Neuroscience. 2008
  PubMed ID: 18495356
   
  
• Regulation of the noradrenaline neurotransmitter phenotype by the transcription factor AP-2beta.
  Hong SJ, Lardaro T, Oh MS, Huh Y, Ding Y, Kang UJ, Kirfel J, Buettner R, Kim KS
  J Biol Chem. 2008
  PubMed ID: 18424435
   
  
• Haplotype analysis of the IGF2-INS-TH gene cluster in Parkinson's disease.
  Sutherland G, Mellick G, Newman J, Double KL, Stevens J, Lee L, Rowe D, Silburn P, Halliday GM
  Am J Med Genet B Neuropsychiatr Genet. 2008
  PubMed ID: 18085551
   
  
• Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling.
  Blaess S, Stephen D, Joyner AL
  Development. 2008
  PubMed ID: 18480159
   
  
• Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors.
  Bonilla S, Hall AC, Pinto L, Attardo A, Götz M, Huttner WB, Arenas E
  Glia. 2008
  PubMed ID: 18351630
   
  
• The therapeutic effects of tyrosine hydroxylase gene transfected hematopoetic stem cells in a rat model of Parkinson's disease.
  Zhang S, Zou Z, Jiang X, Xu R, Zhang W, Zhou Y, Ke Y
  Cell Mol Neurobiol. 2008
  PubMed ID: 17713852
   
  
• Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons.
  Wickramasinghe SR, Alvania RS, Ramanan N, Wood JN, Mandai K, Ginty DD
  Neuron. 2008
  PubMed ID: 18498735
   
  
• Direction selectivity in the retina is established independent of visual experience and cholinergic retinal waves.
  Elstrott J, Anishchenko A, Greschner M, Sher A, Litke AM, Chichilnisky EJ, Feller MB
  Neuron. 2008
  PubMed ID: 18498732
   
  
• Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90.
  He DY, Ron D
  J Biol Chem. 2008
  PubMed ID: 18343820
   
  
• Modular patterning of structure and function of the striatum by retinoid receptor signaling.
  Liao WL, Tsai HC, Wang HF, Chang J, Lu KM, Wu HL, Lee YC, Tsai TF, Takahashi H, Wagner M, Ghyselinck NB, Chambon P, Liu FC
  Proc Natl Acad Sci U S A. 2008
  PubMed ID: 18443282
   
  
• A model for neuronal competition during development.
  Deppmann CD, Mihalas S, Sharma N, Lonze BE, Niebur E, Ginty DD
  Science. 2008
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• Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice.
  Alerte TN, Akinfolarin AA, Friedrich EE, Mader SA, Hong CS, Perez RG
  Neurosci Lett. 2008
  PubMed ID: 18314273
   
  
• Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons.
  Makita T, Sucov HM, Gariepy CE, Yanagisawa M, Ginty DD
  Nature. 2008
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• Sall3 is required for the terminal maturation of olfactory glomerular interneurons.
  Harrison SJ, Parrish M, Monaghan AP
  J Comp Neurol. 2008
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• Dopa decarboxylase and tyrosine hydroxylase gene variants in suicidal behavior.
  Giegling I, Moreno-De-Luca D, Rujescu D, Schneider B, Hartmann AM, Schnabel A, Maurer K, Möller HJ, Serretti A
  Am J Med Genet B Neuropsychiatr Genet. 2008
  PubMed ID: 17948905
   
  
• Selective losses of brainstem catecholamine neurons after hypoxia-ischemia in the immature rat pup.
  Buller KM, Wixey JA, Pathipati P, Carty M, Colditz PB, Williams CE, Scheepens A
  Pediatr Res. 2008
  PubMed ID: 18356740
   
  
• Differential expression and dynamic changes of murine NEDD9 in progenitor cells of diverse tissues.
  Aquino JB, Marmigère F, Lallemend F, Lundgren TK, Villar MJ, Wegner M, Ernfors P
  Gene Expr Patterns. 2008
  PubMed ID: 18282814
   
  
• Activity-dependent regulation of tyrosine hydroxylase expression in the enteric nervous system.
  Chevalier J, Derkinderen P, Gomes P, Thinard R, Naveilhan P, Vanden Berghe P, Neunlist M
  J Physiol. 2008
  PubMed ID: 18258664
   
  
• Reduced striatal tyrosine hydroxylase in incidental Lewy body disease.
  Beach TG, Adler CH, Sue LI, Peirce JB, Bachalakuri J, Dalsing-Hernandez JE, Lue LF, Caviness JN, Connor DJ, Sabbagh MN, Walker DG
  Acta Neuropathol. 2008
  PubMed ID: 17985144
   
  
• Oxygen dependence of tyrosine hydroxylase.
  Rostrup M, Fossbakk A, Hauge A, Kleppe R, Gnaiger E, Haavik J
  Amino Acids. 2008
  PubMed ID: 17520326
   
  
• A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors.
  Qiu F, Jiang H, Xiang M
  J Neurosci. 2008
  PubMed ID: 18367606
   
  
• A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice--as a mouse model for Parkinson's disease.
  Takazawa C, Fujimoto K, Homma D, Sumi-Ichinose C, Nomura T, Ichinose H, Katoh S
  Biochem Biophys Res Commun. 2008
  PubMed ID: 18201550
   
  
• Plexin-A3 and plexin-A4 restrict the migration of sympathetic neurons but not their neural crest precursors.
  Waimey KE, Huang PH, Chen M, Cheng HJ
  Dev Biol. 2008
  PubMed ID: 18262512
   
  
• Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor.
  Vizard TN, O'Keeffe GW, Gutierrez H, Kos CH, Riccardi D, Davies AM
  Nat Neurosci. 2008
  PubMed ID: 18223649
   
  
• Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development.
  Basson MA, Echevarria D, Ahn CP, Sudarov A, Joyner AL, Mason IJ, Martinez S, Martin GR
  Development. 2008
  PubMed ID: 18216176
   
  
• Tyrosine hydroxylase-positive GABAergic juxtaglomerular neurons are the main source of the interglomerular connections in the mouse main olfactory bulb.
  Kosaka T, Kosaka K
  Neurosci Res. 2008
  PubMed ID: 18206259
   
  
• Differential expressions and roles of hypoxia-inducible factor-1alpha, -2alpha and -3alpha in the rat carotid body during chronic and intermittent hypoxia.
  Lam SY, Tipoe GL, Liong EC, Fung ML
  Histol Histopathol. 2008
  PubMed ID: 18072084
   
  
• Influence of the tyrosine hydroxylase val81met polymorphism and catechol-O-methyltransferase val158met polymorphism on the antidepressant effect of milnacipran.
  Yoshida K, Higuchi H, Takahashi H, Kamata M, Sato K, Inoue K, Suzuki T, Itoh K, Ozaki N
  Hum Psychopharmacol. 2008
  PubMed ID: 18023073
   
  
• Worldwide genetic variation in dopamine and serotonin pathway genes: Implications for association studies.
  Gardner M, Bertranpetit J, Comas D
  Am J Med Genet B Neuropsychiatr Genet. 2008
  PubMed ID: 18270970
   
  
• The 14-3-3 protein affects the conformation of the regulatory domain of human tyrosine hydroxylase.
  Obsilova V, Nedbalkova E, Silhan J, Boura E, Herman P, Vecer J, Sulc M, Teisinger J, Dyda F, Obsil T
  Biochemistry. 2008
  PubMed ID: 18181650
   
  
• Regulation of sympathetic neuron differentiation by endogenous nerve growth factor and neurotrophin-3.
  Andres R, Herraez-Baranda LA, Thompson J, Wyatt S, Davies AM
  Neurosci Lett. 2008
  PubMed ID: 18162309
   
  
• Tyrosine hydroxylase cells appearing in the mouse striatum after dopamine denervation are likely to be projection neurones regulated by L-DOPA.
  Darmopil S, Muñetón-Gómez VC, de Ceballos ML, Bernson M, Moratalla R
  Eur J Neurosci. 2008
  PubMed ID: 18279311
   
  
• FRS2 alpha 2F/2F mice lack carotid body and exhibit abnormalities of the superior cervical sympathetic ganglion and carotid sinus nerve.
  Kameda Y, Ito M, Nishimaki T, Gotoh N
  Dev Biol. 2008
  PubMed ID: 18177855
   
  
• Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage.
  Wildner H, Gierl MS, Strehle M, Pla P, Birchmeier C
  Development. 2008
  PubMed ID: 18094025
   
  
• Presence of corticotrophin-releasing factor and/or tyrosine hydroxylase in cells of a neural brain-testicular pathway that are labelled by a transganglionic tracer.
  James P, Rivier C, Lee S
  J Neuroendocrinol. 2008
  PubMed ID: 18047555
   
  
• Delta-like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons.
  Bauer M, Szulc J, Meyer M, Jensen CH, Terki TA, Meixner A, Kinkl N, Gasser T, Aebischer P, Ueffing M
  J Neurochem. 2008
  PubMed ID: 17986227
   
  
• A functional intronic variant in tyrosine hydroxylase (TH) gene confers risk of essential hypertension in northern Chinese Han population.
  Wang L, Li B, Lu X, Zhao Q, Li Y, Ge D, Li H, Zhang P, Chen S, Chen R, Qiang B, Gu D
  Clin Sci (Lond). 2008
  PubMed ID: 18208403
   
  
• A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons.
  Dubreuil V, Ramanantsoa N, Trochet D, Vaubourg V, Amiel J, Gallego J, Brunet JF, Goridis C
  Proc Natl Acad Sci U S A. 2008
  PubMed ID: 18198276
   
  
• Subthalamic stimulation increases striatal tyrosine hydroxylase phosphorylation.
  Reese R, Winter C, Nadjar A, Harnack D, Morgenstern R, Kupsch A, Bezard E, Meissner W
  Neuroreport. 2008
  PubMed ID: 18185104
   
  
• Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum.
  Arlotta P, Molyneaux BJ, Jabaudon D, Yoshida Y, Macklis JD
  J Neurosci. 2008
  PubMed ID: 18199763
   
  
• Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphology.
  Rotolo T, Smallwood PM, Williams J, Nathans J
  PLoS ONE. 2008
  PubMed ID: 19116659
   
  
• Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo.
  Andersson ER, Prakash N, Cajanek L, Minina E, Bryja V, Bryjova L, Yamaguchi TP, Hall AC, Wurst W, Arenas E
  PLoS ONE. 2008
  PubMed ID: 18953410
   
  
• Effects of anonaine on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells.
  Lee JJ, Jin CM, Kim YK, Ryu SY, Lim SC, Lee MK
  Molecules. 2008
  PubMed ID: 18305432
   
  
• TH and NPY in sympathetic neurovascular cultures: role of LIF and NT-3.
  Damon DH
  Am J Physiol Cell Physiol. 2008
  PubMed ID: 18032527
   
  
• Postinfarct sympathetic hyperactivity differentially stimulates expression of tyrosine hydroxylase and norepinephrine transporter.
  Parrish DC, Gritman K, Van Winkle DM, Woodward WR, Bader M, Habecker BA
  Am J Physiol Heart Circ Physiol. 2008
  PubMed ID: 17951370
   
  
• Expression of connexin30.2 in interneurons of the central nervous system in the mouse.
  Kreuzberg MM, Deuchars J, Weiss E, Schober A, Sonntag S, Wellershaus K, Draguhn A, Willecke K
  Mol Cell Neurosci. 2008
  PubMed ID: 17942321
   
  
• Power based association analysis (PBAT) of serotonergic and noradrenergic polymorphisms in bipolar patients with suicidal behaviour.
  De Luca V, Strauss J, Kennedy JL
  Prog Neuropsychopharmacol Biol Psychiatry. 2008
  PubMed ID: 17869399
   
  
• Neuronal nitric oxide synthase gene inactivation reduces the expression of vasopressin in the hypothalamic paraventricular nucleus and of catecholamine biosynthetic enzymes in the adrenal gland of the mouse.
  Orlando GF, Langnaese K, Schulz C, Wolf G, Engelmann M
  Stress. 2008
  PubMed ID: 17853069
   
  
• The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age.
  Kittappa R, Chang WW, Awatramani RB, McKay RD
  PLoS Biol. 2007
  PubMed ID: 18076286
   
  
• Up-regulation of IL-1 receptor type I and tyrosine hydroxylase in the rat carotid body following intraperitoneal injection of IL-1beta.
  Zhang XJ, Wang X, Xiong LZ, Fan J, Duan XL, Wang BR
  Histochem Cell Biol. 2007
  PubMed ID: 17926059
   
  
• Regulation of serine (Ser)-31 and Ser40 tyrosine hydroxylase phosphorylation during morphine withdrawal in the hypothalamic paraventricular nucleus and nucleus tractus solitarius-A2 cell group: role of ERK1/2.
  Núñez C, Laorden ML, Milanés MV
  Endocrinology. 2007
  PubMed ID: 17823252
   
  
• Pubertal impairment in Nhlh2 null mice is associated with hypothalamic and pituitary deficiencies.
  Cogliati T, Delgado-Romero P, Norwitz ER, Guduric-Fuchs J, Kaiser UB, Wray S, Kirsch IR
  Mol Endocrinol. 2007
  PubMed ID: 17717072
   
  
• RNAi of 14-3-3eta protein increases intracellular stability of tyrosine hydroxylase.
  Nakashima A, Hayashi N, Kaneko YS, Mori K, Sabban EL, Nagatsu T, Ota A
  Biochem Biophys Res Commun. 2007
  PubMed ID: 17900529
   
  
• Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes.
  Vadasz C, Smiley JF, Figarsky K, Saito M, Toth R, Gyetvai BM, Oros M, Kovacs KK, Mohan P, Wang R
  Neuroscience. 2007
  PubMed ID: 17920205
   
  
• [The mRNA expression levels of IL-1beta, TNF-alpha and tyrosine hydroxylase in peripheral blood of paranoid schizophrenic patients]
  Liu L, Jia FJ, Li HF
  Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007
  PubMed ID: 17988588
   
  
• A homozygous tyrosine hydroxylase gene promoter mutation in a patient with dopa-responsive encephalopathy: clinical, biochemical and genetic analysis.
  Ribasés M, Serrano M, Fernández-Alvarez E, Pahisa S, Ormazabal A, García-Cazorla A, Pérez-Dueñas B, Campistol J, Artuch R, Cormand B
  Mol Genet Metab. 2007
  PubMed ID: 17698383
   
  
• Cell death in the Purkinje cells of the cerebellum of senescence accelerated mouse (SAMP(8)).
  Zhu Y, Lee CC, Lam WP, Wai MS, Rudd JA, Yew DT
  Biogerontology. 2007
  PubMed ID: 17415677
   
  
• The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors.
  Flora A, Garcia JJ, Thaller C, Zoghbi HY
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17878293
   
  
• Dmbx1 is essential in agouti-related protein action.
  Fujimoto W, Shiuchi T, Miki T, Minokoshi Y, Takahashi Y, Takeuchi A, Kimura K, Saito M, Iwanaga T, Seino S
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17873059
   
  
• Colocalization of somatostatin receptor subtypes (SSTR1-5) with somatostatin, NADPH-diaphorase (NADPH-d), and tyrosine hydroxylase in the rat hypothalamus.
  Kumar U
  J Comp Neurol. 2007
  PubMed ID: 17626271
   
  
• Association of gastric cancer with tyrosine hydroxylase gene polymorphism in a northwestern Chinese population.
  Li ZQ, Yu WP, Xie XD, Li PQ, Guo TK, Zhang WH, An LZ, Wang XL
  Clin Exp Med. 2007
  PubMed ID: 17972051
   
  
• OL-Protocadherin is essential for growth of striatal axons and thalamocortical projections.
  Uemura M, Nakao S, Suzuki ST, Takeichi M, Hirano S
  Nat Neurosci. 2007
  PubMed ID: 17721516
   
  
• Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages.
  Schreiner S, Cossais F, Fischer K, Scholz S, Bösl MR, Holtmann B, Sendtner M, Wegner M
  Development. 2007
  PubMed ID: 17699610
   
  
• Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells.
  Ono Y, Nakatani T, Sakamoto Y, Mizuhara E, Minaki Y, Kumai M, Hamaguchi A, Nishimura M, Inoue Y, Hayashi H, Takahashi J, Imai T
  Development. 2007
  PubMed ID: 17670789
   
  
• Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome.
  Zhang B, Jain S, Song H, Fu M, Heuckeroth RO, Erlich JM, Jay PY, Milbrandt J
  Development. 2007
  PubMed ID: 17652350
   
  
• Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line.
  Bosier B, Tilleux S, Najimi M, Lambert DM, Hermans E
  J Neurochem. 2007
  PubMed ID: 17540007
   
  
• Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo.
  Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork NJ, Taupenot L, Ziegler MG, O'Connor DT
  Circulation. 2007
  PubMed ID: 17698732
   
  
• Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain.
  Saarimäki-Vire J, Peltopuro P, Lahti L, Naserke T, Blak AA, Vogt Weisenhorn DM, Yu K, Ornitz DM, Wurst W, Partanen J
  J Neurosci. 2007
  PubMed ID: 17687036
   
  
• Tyrosine hydroxylase deficiency presenting with a biphasic clinical course.
  Giovanniello T, Leuzzi V, Carducci C, Carducci C, Sabato ML, Artiola C, Santagata S, Pozzessere S, Antonozzi I
  Neuropediatrics. 2007
  PubMed ID: 18058633
   
  
• Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells.
  Kumar M, Bagchi B, Gupta SK, Meena AS, Gressens P, Mani S
  Stem Cells Dev. 2007
  PubMed ID: 17784840
   
  
• Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner.
  Ferri AL, Lin W, Mavromatakis YE, Wang JC, Sasaki H, Whitsett JA, Ang SL
  Development. 2007
  PubMed ID: 17596284
   
  
• Nicotine induces tyrosine hydroxylase plasticity in the neurodegenerating striatum.
  Urbanavicius J, Ferreira M, Costa G, Abin-Carriquiry JA, Wonnacott S, Dajas F
  J Neurochem. 2007
  PubMed ID: 17437548
   
  
• Sodium butyrate modifies the stabilizing complexes of tyrosine hydroxylase mRNA.
  Arányi T, Sarkis C, Berrard S, Sardin K, Siron V, Khalfallah O, Mallet J
  Biochem Biophys Res Commun. 2007
  PubMed ID: 17524356
   
  
• Evidence for regulation of tyrosine hydroxylase mRNA translation by stress in rat adrenal medulla.
  Xu L, Chen X, Sun B, Sterling C, Tank AW
  Brain Res. 2007
  PubMed ID: 17543899
   
  
• Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency.
  Jacobs FM, Smits SM, Noorlander CW, von Oerthel L, van der Linden AJ, Burbach JP, Smidt MP
  Development. 2007
  PubMed ID: 17592014
   
  
• Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system.
  Morikawa Y, D'Autréaux F, Gershon MD, Cserjesi P
  Dev Biol. 2007
  PubMed ID: 17531968
   
  
• Embryonic and postnatal development of the serotonergic raphe system and its target regions in 5-HT1A receptor deletion or overexpressing mouse mutants.
  Deng DR, Djalali S, Höltje M, Grosse G, Stroh T, Voigt I, Kusserow H, Theuring F, Ahnert-Hilger G, Hörtnagl H
  Neuroscience. 2007
  PubMed ID: 17543467
   
  
• A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors.
  Kohwi M, Petryniak MA, Long JE, Ekker M, Obata K, Yanagawa Y, Rubenstein JL, Alvarez-Buylla A
  J Neurosci. 2007
  PubMed ID: 17596436
   
  
• Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome.
  Van de Putte T, Francis A, Nelles L, van Grunsven LA, Huylebroeck D
  Hum Mol Genet. 2007
  PubMed ID: 17478475
   
  
• Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage.
  Val P, Martinez-Barbera JP, Swain A
  Development. 2007
  PubMed ID: 17537799
   
  
• Neuronal PAS domain protein 1 regulates tyrosine hydroxylase level in dopaminergic neurons.
  Teh CH, Loh CC, Lam KK, Loo JM, Yan T, Lim TM
  J Neurosci Res. 2007
  PubMed ID: 17457889
   
  
• Alpha11 beta1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor.
  Popova SN, Barczyk M, Tiger CF, Beertsen W, Zigrino P, Aszodi A, Miosge N, Forsberg E, Gullberg D
  Mol Cell Biol. 2007
  PubMed ID: 17420280
   
  
• Tyrosine hydroxylase and dopamine transporter expression in lactotrophs from postlactating rats: involvement in dopamine-induced apoptosis.
  Jaubert A, Drutel G, Leste-Lasserre T, Ichas F, Bresson-Bepoldin L
  Endocrinology. 2007
  PubMed ID: 17363452
   
  
• Emergence of the sensory nervous system as defined by Foxs1 expression.
  Montelius A, Marmigère F, Baudet C, Aquino JB, Enerbäck S, Ernfors P
  Differentiation. 2007
  PubMed ID: 17309606
   
  
• Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis.
  Cheng LE, Reed RR
  Neuron. 2007
  PubMed ID: 17521568
   
  
• Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors.
  Inoue T, Ota M, Ogawa M, Mikoshiba K, Aruga J
  J Neurosci. 2007
  PubMed ID: 17507568
   
  
• EphB1 null mice exhibit neuronal loss in substantia nigra pars reticulata and spontaneous locomotor hyperactivity.
  Richards AB, Scheel TA, Wang K, Henkemeyer M, Kromer LF
  Eur J Neurosci. 2007
  PubMed ID: 17561836
   
  
• Patterning of frontal cortex subdivisions by Fgf17.
  Cholfin JA, Rubenstein JL
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17442747
   
  
• Sema3a maintains normal heart rhythm through sympathetic innervation patterning.
  Ieda M, Kanazawa H, Kimura K, Hattori F, Ieda Y, Taniguchi M, Lee JK, Matsumura K, Tomita Y, Miyoshi S, Shimoda K, Makino S, Sano M, Kodama I, Ogawa S, Fukuda K
  Nat Med. 2007
  PubMed ID: 17417650
   
  
• Specific ablation of the transcription factor CREB in sympathetic neurons surprisingly protects against developmentally regulated apoptosis.
  Parlato R, Otto C, Begus Y, Stotz S, Schütz G
  Development. 2007
  PubMed ID: 17376811
   
  
• Transcription and epigenetic profile of the promoter, first exon and first intron of the human tyrosine hydroxylase gene.
  Romano G, Macaluso M, Lucchetti C, Iacovitti L
  J Cell Physiol. 2007
  PubMed ID: 17195153
   
  
• Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation.
  Colombo E, Collombat P, Colasante G, Bianchi M, Long J, Mansouri A, Rubenstein JL, Broccoli V
  J Neurosci. 2007
  PubMed ID: 17460091
   
  
• Characterisation of novel splicing variants of the tyrosine hydroxylase C-terminal domain in human neuroblastic tumours.
  Roma J, Saus E, Cuadros M, Reventós J, Sánchez de Toledo J, Gallego S
  Biol Chem. 2007
  PubMed ID: 17391063
   
  
• Evaluation of anti-Fas ligand-induced apoptosis and neural differentiation of PC12 cells treated with nerve growth factor using small interfering RNA method and sampling by microdialysis.
  Chiou SH, Kao CL, Chang YL, Ku HH, Tsai YJ, Lin HT, Yen CJ, Peng CH, Chiu JH, Tsai TH
  Anal Biochem. 2007
  PubMed ID: 17306206
   
  
• Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells.
  Andersson EK, Irvin DK, Ahlsiö J, Parmar M
  Exp Cell Res. 2007
  PubMed ID: 17291494
   
  
• Corticotropin-releasing factor (CRF) and the urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRF receptor type-specific manner.
  Dermitzaki E, Tsatsanis C, Minas V, Chatzaki E, Charalampopoulos I, Venihaki M, Androulidaki A, Lambropoulou M, Spiess J, Michalodimitrakis E, Gravanis A, Margioris AN
  Endocrinology. 2007
  PubMed ID: 17194738
   
  
• Alpha-synuclein and tyrosine hydroxylase expression in acute rotenone toxicity.
  Luo C, Rajput AH, Akhtar S, Rajput A
  Int J Mol Med. 2007
  PubMed ID: 17273802
   
  
• Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain.
  Blak AA, Naserke T, Saarimäki-Vire J, Peltopuro P, Giraldo-Velasquez M, Vogt Weisenhorn DM, Prakash N, Sendtner M, Partanen J, Wurst W
  Dev Biol. 2007
  PubMed ID: 17150206
   
  
• Aging of the rat mesostriatal system: differences between the nigrostriatal and the mesolimbic compartments.
  Cruz-Muros I, Afonso-Oramas D, Abreu P, Barroso-Chinea P, Rodríguez M, González MC, Hernández TG
  Exp Neurol. 2007
  PubMed ID: 17112516
   
  
• Delayed increase of tyrosine hydroxylase expression in rat nigrostriatal system after traumatic brain injury.
  Yan HQ, Ma X, Chen X, Li Y, Shao L, Dixon CE
  Brain Res. 2007
  PubMed ID: 17196177
   
  
• Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study.
  Ton TG, Rossing MA, Bowen DJ, Srinouanprachan S, Wicklund K, Farin FM
  Behav Brain Funct. 2007
  PubMed ID: 17466074
   
  
• PreproThyrotropin-releasing hormone 178-199 affects tyrosine hydroxylase biosynthesis in hypothalamic neurons: a possible role for pituitary prolactin regulation.
  Goldstein J, Perello M, Nillni EA
  J Mol Neurosci. 2007
  PubMed ID: 17416971
   
  
• Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice.
  Guo C, Qiu HY, Huang Y, Chen H, Yang RQ, Chen SD, Johnson RL, Chen ZF, Ding YQ
  Development. 2007
  PubMed ID: 17166916
   
  
• Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons.
  Zhang J, Pho V, Bonasera SJ, Holtzman J, Tang AT, Hellmuth J, Tang S, Janak PH, Tecott LH, Huang EJ
  Nat Neurosci. 2007
  PubMed ID: 17159989
   
  
• Multiple co-localizations in arcuate GHRH-eGFP neurons in the mouse hypothalamus.
  Bouyer K, Loudes C, Robinson IC, Epelbaum J, Faivre-Bauman A
  J Chem Neuroanat. 2007
  PubMed ID: 17137749
   
  
• Expression of Hand2 is sufficient for neurogenesis and cell type-specific gene expression in the enteric nervous system.
  Hendershot TJ, Liu H, Sarkar AA, Giovannucci DR, Clouthier DE, Abe M, Howard MJ
  Dev Dyn. 2007
  PubMed ID: 17075884
   
  
• Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina.
  Feng L, Xie X, Joshi PS, Yang Z, Shibasaki K, Chow RL, Gan L
  Development. 2006
  PubMed ID: 17092954
   
  
• Nerve growth factor is critical for cardiac sensory innervation and rescues neuropathy in diabetic hearts.
  Ieda M, Kanazawa H, Ieda Y, Kimura K, Matsumura K, Tomita Y, Yagi T, Onizuka T, Shimoji K, Ogawa S, Makino S, Sano M, Fukuda K
  Circulation. 2006
  PubMed ID: 17101855
   
  
• Vesicular glutamate transporter 2 is required for central respiratory rhythm generation but not for locomotor central pattern generation.
  Wallén-Mackenzie A, Gezelius H, Thoby-Brisson M, Nygård A, Enjin A, Fujiyama F, Fortin G, Kullander K
  J Neurosci. 2006
  PubMed ID: 17122055
   
  
• The effect of streptozotocin-induced diabetes on the rat seminal vesicle: A possible pathophysiological basis for disorders of ejaculation.
  Morrison JF, Dhanasekaran S, Sheen R, Frampton CM, Mensah-Brown E
  Ann N Y Acad Sci. 2006
  PubMed ID: 17151307
   
  
• Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells.
  Asai N, Fukuda T, Wu Z, Enomoto A, Pachnis V, Takahashi M, Costantini F
  Development. 2006
  PubMed ID: 17050626
   
  
• Generation of GABAergic and dopaminergic interneurons from endogenous embryonic olfactory bulb precursor cells.
  Vergaño-Vera E, Yusta-Boyo MJ, de Castro F, Bernad A, de Pablo F, Vicario-Abejón C
  Development. 2006
  PubMed ID: 17038521
   
  
• Will genetic polymorphism of tetranucleotide sequences help in the diagnostics of major psychiatric disorders?
  Jacewicz R, Szram S, Gałecki P, Berent J
  Forensic Sci Int. 2006
  PubMed ID: 16887311
   
  
• A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene.
  Kelly BB, Hedlund E, Kim C, Ishiguro H, Isacson O, Chikaraishi DM, Kim KS, Feng G
  Neuroscience. 2006
  PubMed ID: 16876957
   
  
• BMPs, FGF8 and Wnts regulate the differentiation of locus coeruleus noradrenergic neuronal precursors.
  Holm PC, Rodríguez FJ, Kele J, Castelo-Branco G, Kitajewski J, Arenas E
  J Neurochem. 2006
  PubMed ID: 16987254
   
  
• Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.
  Bouwman J, Spijker S, Schut D, Wächtler B, Ylstra B, Smit AB, Verhage M
  J Neurochem. 2006
  PubMed ID: 16987237
   
  
• Megane/Heslike is required for normal GABAergic differentiation in the mouse superior colliculus.
  Guimera J, Weisenhorn DV, Wurst W
  Development. 2006
  PubMed ID: 16968817
   
  
• Gata3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation.
  Moriguchi T, Takako N, Hamada M, Maeda A, Fujioka Y, Kuroha T, Huber RE, Hasegawa SL, Rao A, Yamamoto M, Takahashi S, Lim KC, Engel JD
  Development. 2006
  PubMed ID: 16943277
   
  
• FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region.
  Jukkola T, Lahti L, Naserke T, Wurst W, Partanen J
  Dev Biol. 2006
  PubMed ID: 16782087
   
  
• Transforming growth factor beta is required for differentiation of mouse mesencephalic progenitors into dopaminergic neurons in vitro and in vivo: ectopic induction in dorsal mesencephalon.
  Roussa E, Wiehle M, Dünker N, Becker-Katins S, Oehlke O, Krieglstein K
  Stem Cells. 2006
  PubMed ID: 16741229
   
  
• Mice without transcription factor KLF7 provide new insight into olfactory bulb development.
  Laub F, Dragomir C, Ramirez F
  Brain Res. 2006
  PubMed ID: 16814267
   
  
• PRUNE and NM23-M1 expression in embryonic and adult mouse brain.
  Carotenuto P, Marino N, Bello AM, D'Angelo A, Di Porzio U, Lombardi D, Zollo M
  J Bioenerg Biomembr. 2006
  PubMed ID: 17033939
   
  
• Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia.
  Li D, He L
  Hum Genet. 2006
  PubMed ID: 16741719
   
  
• Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor.
  Kim SM, Yang JW, Park MJ, Lee JK, Kim SU, Lee YS, Lee MA
  Biochem Biophys Res Commun. 2006
  PubMed ID: 16764822
   
  
• DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor.
  Zhong N, Kim CY, Rizzu P, Geula C, Porter DR, Pothos EN, Squitieri F, Heutink P, Xu J
  J Biol Chem. 2006
  PubMed ID: 16731528
   
  
• Regulation of tyrosine hydroxylase gene expression by retinoic acid receptor.
  Jeong H, Kim MS, Kim SW, Kim KS, Seol W
  J Neurochem. 2006
  PubMed ID: 16805833
   
  
• Development and topography of the lateral olfactory tract in the mouse: imaging by genetically encoded and injected fluorescent markers.
  Walz A, Omura M, Mombaerts P
  J Neurobiol. 2006
  PubMed ID: 16673392
   
  
• Time course analysis of tyrosine hydroxylase and angiotensinogen mRNA expression in central nervous system of rats submitted to experimental hypertension.
  Maximino JR, Ferrari MF, Coelho EF, Fior-Chadi DR
  Neurosci Res. 2006
  PubMed ID: 16650497
   
  
• Tyrosine hydroxylase is expressed in a subpopulation of small dorsal root ganglion neurons in the adult mouse.
  Brumovsky P, Villar MJ, Hökfelt T
  Exp Neurol. 2006
  PubMed ID: 16516890
   
  
• Mash1 is required for generic and subtype differentiation of hypothalamic neuroendocrine cells.
  McNay DE, Pelling M, Claxton S, Guillemot F, Ang SL
  Mol Endocrinol. 2006
  PubMed ID: 16469766
   
  
• Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation.
  Lehmann IT, Bobrovskaya L, Gordon SL, Dunkley PR, Dickson PW
  J Biol Chem. 2006
  PubMed ID: 16644734
   
  
• Doxycycline-regulated co-expression of GDNF and TH in PC12 cells.
  Wang JJ, Zhang T, Niu DB, Wang K, Li KR, Xue B, Wang XM
  Neurosci Lett. 2006
  PubMed ID: 16584838
   
  
• Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia.
  Hnasko TS, Perez FA, Scouras AD, Stoll EA, Gale SD, Luquet S, Phillips PE, Kremer EJ, Palmiter RD
  Proc Natl Acad Sci U S A. 2006
  PubMed ID: 16723393
   
  
• A flexible loop in tyrosine hydroxylase controls coupling of amino acid hydroxylation to tetrahydropterin oxidation.
  Daubner SC, McGinnis JT, Gardner M, Kroboth SL, Morris AR, Fitzpatrick PF
  J Mol Biol. 2006
  PubMed ID: 16618490
   
  
• Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese.
  Gu D, Su S, Ge D, Chen S, Huang J, Li B, Chen R, Qiang B
  Hypertension. 2006
  PubMed ID: 16636198
   
  
• Human glioblastoma ADF cells express tyrosinase, L-tyrosine hydroxylase and melanosomes and are sensitive to L-tyrosine and phenylthiourea.
  Bonfigli A, Zarivi O, Colafarina S, Cimini AM, Ragnelli AM, Aimola P, Natali PG, Cerù MP, Amicarelli F, Miranda M
  J Cell Physiol. 2006
  PubMed ID: 16447258
   
  
• Dynamic temporal and cell type-specific expression of Wnt signaling components in the developing midbrain.
  Rawal N, Castelo-Branco G, Sousa KM, Kele J, Kobayashi K, Okano H, Arenas E
  Exp Cell Res. 2006
  PubMed ID: 16510140
   
  
• Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border.
  Griesel G, Treichel D, Collombat P, Krull J, Zembrzycki A, van den Akker WM, Gruss P, Simeone A, Mansouri A
  Development. 2006
  PubMed ID: 16571633
   
  
• Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region.
  Blaess S, Corrales JD, Joyner AL
  Development. 2006
  PubMed ID: 16571630
   
  
• The dopamine D2 receptor regulates the development of dopaminergic neurons via extracellular signal-regulated kinase and Nurr1 activation.
  Kim SY, Choi KC, Chang MS, Kim MH, Kim SY, Na YS, Lee JE, Jin BK, Lee BH, Baik JH
  J Neurosci. 2006
  PubMed ID: 16641236
   
  
• Differential distributions of the Ca2+ -dependent activator protein for secretion family proteins (CAPS2 and CAPS1) in the mouse brain.
  Sadakata T, Itakura M, Kozaki S, Sekine Y, Takahashi M, Furuichi T
  J Comp Neurol. 2006
  PubMed ID: 16506193
   
  
• Prolonged activation of cAMP-response element-binding protein and ATF-2 needed for nicotine-triggered elevation of tyrosine hydroxylase gene transcription in PC12 cells.
  Gueorguiev VD, Cheng SY, Sabban EL
  J Biol Chem. 2006
  PubMed ID: 16452470
   
  
• Low frequency of Parkin, Tyrosine Hydroxylase, and GTP Cyclohydrolase I gene mutations in a Danish population of early-onset Parkinson's Disease.
  Hertz JM, Ostergaard K, Juncker I, Pedersen S, Romstad A, Møller LB, Güttler F, Dupont E
  Eur J Neurol. 2006
  PubMed ID: 16643317
   
  
• BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
  Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
  PLoS Biol. 2006
  PubMed ID: 16602821
   
  
• Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously.
  Hirata T, Nakazawa M, Yoshihara S, Miyachi H, Kitamura K, Yoshihara Y, Hibi M
  Development. 2006
  PubMed ID: 16540508
   
  
• Up-regulation of tyrosine hydroxylase gene transcription by tetradecanoylphorbol acetate is mediated by the transcription factors Ets-like protein-1 (Elk-1) and Egr-1.
  Stefano L, Al Sarraj J, Rössler OG, Vinson C, Thiel G
  J Neurochem. 2006
  PubMed ID: 16515541
   
  
• Kinetics of regulatory serine variants of tyrosine hydroxylase with cyclic AMP-dependent protein kinase and extracellular signal-regulated protein kinase 2.
  Royo M, Colette Daubner S
  Biochim Biophys Acta. 2006
  PubMed ID: 16503426
   
  
• Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats.
  Inouye KE, Yue JT, Chan O, Kim T, Akirav EM, Park E, Riddell MC, Burdett E, Matthews SG, Vranic M
  Endocrinology. 2006
  PubMed ID: 16396986
   
  
• Tyrosine hydroxylase gene regulation in human neuronal progenitor cells does not depend on Nurr1 as in the murine and rat systems.
  Jin H, Romano G, Marshall C, Donaldson AE, Suon S, Iacovitti L
  J Cell Physiol. 2006
  PubMed ID: 16252282
   
  
• Human chromosome 11 DNA sequence and analysis including novel gene identification.
  Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
  Nature. 2006
  PubMed ID: 16554811
   
  
• Regulation of the transcriptional activity of the tyrosine hydroxylase gene by androgen receptor.
  Jeong H, Kim MS, Kwon J, Kim KS, Seol W
  Neurosci Lett. 2006
  PubMed ID: 16356647
   
  
• Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice.
  Li ZS, Schmauss C, Cuenca A, Ratcliffe E, Gershon MD
  J Neurosci. 2006
  PubMed ID: 16525059
   
  
• Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon.
  Thompson LH, Andersson E, Jensen JB, Barraud P, Guillemot F, Parmar M, Björklund A
  Exp Neurol. 2006
  PubMed ID: 16438966
   
  
• Combined analysis of association between personality traits and three functional polymorphisms in the tyrosine hydroxylase, monoamine oxidase A, and catechol-O-methyltransferase genes.
  Tochigi M, Otowa T, Hibino H, Kato C, Otani T, Umekage T, Utsumi T, Kato N, Sasaki T
  Neurosci Res. 2006
  PubMed ID: 16360899
   
  
• The inhibitory effects of deltamethrin on dopamine biosynthesis in rat PC12 cells.
  Liu GP, Shi N
  Toxicol Lett. 2006
  PubMed ID: 16229977
   
  
• Effect of anti-NGF on ovarian expression of alpha1- and beta2-adrenoceptors, TrkA, p75NTR, and tyrosine hydroxylase in rats with steroid-induced polycystic ovaries.
  Manni L, Holmäng A, Cajander S, Lundeberg T, Aloe L, Stener-Victorin E
  Am J Physiol Regul Integr Comp Physiol. 2006
  PubMed ID: 16195501
   
  
• Reduction and oxidation of the active site iron in tyrosine hydroxylase: kinetics and specificity.
  Frantom PA, Seravalli J, Ragsdale SW, Fitzpatrick PF
  Biochemistry. 2006
  PubMed ID: 16475826
   
  
• The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons.
  Waclaw RR, Allen ZJ, Bell SM, Erdélyi F, Szabó G, Potter SS, Campbell K
  Neuron. 2006
  PubMed ID: 16476661
   
  
• Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla.
  Oberle S, Schober A, Meyer V, Holtmann B, Henderson C, Sendtner M, Unsicker K
  J Neurosci. 2006
  PubMed ID: 16467531
   
  
• Ectopic expression of tyrosine hydroxylase in the pigmented epithelium rescues the retinal abnormalities and visual function common in albinos in the absence of melanin.
  Lavado A, Jeffery G, Tovar V, de la Villa P, Montoliu L
  J Neurochem. 2006
  PubMed ID: 16445854
   
  
• Substrate-mediated enhancement of phosphorylated tyrosine hydroxylase in nigrostriatal dopamine neurons: evidence for a role of alpha-synuclein.
  Drolet RE, Behrouz B, Lookingland KJ, Goudreau JL
  J Neurochem. 2006
  PubMed ID: 16412098
   
  
• Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons.
  Kele J, Simplicio N, Ferri AL, Mira H, Guillemot F, Arenas E, Ang SL
  Development. 2006
  PubMed ID: 16410412
   
  
• Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2.
  Andersson E, Jensen JB, Parmar M, Guillemot F, Björklund A
  Development. 2006
  PubMed ID: 16396906
   
  
• Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain.
  Wijchers PJ, Hoekman MF, Burbach JP, Smidt MP
  Brain Res. 2006
  PubMed ID: 16376864
   
  
• No evidence of an association between tyrosine hydroxylase gene polymorphisms and suicide victims.
  Hattori H, Shirakawa O, Nishiguchi N, Nushida H, Ueno Y, Maeda K
  Kobe J Med Sci. 2006
  PubMed ID: 17329957
   
  
• Co-expression of tyrosine hydroxylase and GTP cyclohydrolase I in arginine vasopressin-synthesizing neurons of the human supraoptic nucleus demonstrated by laser microdissection and real-time PCR.
  Kontostavlaki DP, Panayotacopoulou MT, Sluijs JA, Unmehopa UA, Huitinga I, Hol EM, Swaab DF
  Neuroendocrinology. 2006
  PubMed ID: 17135716
   
  
• No association of DRD2, DRD3, and tyrosine hydroxylase gene polymorphisms with personality traits in the Japanese population.
  Hibino H, Tochigi M, Otowa T, Kato N, Sasaki T
  Behav Brain Funct. 2006
  PubMed ID: 17018139
   
  
• Compensation by tumor suppressor genes during retinal development in mice and humans.
  Donovan SL, Schweers B, Martins R, Johnson D, Dyer MA
  BMC Biol. 2006
  PubMed ID: 16672052
   
  
• A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys.
  Rodríguez S, Huang S, Chen XH, Gaunt TR, Syddall HE, Gilg JA, Miller GJ, Cooper CC, Cook DG, Whincup PH, Day IN
  Pharmacogenet Genomics. 2006
  PubMed ID: 16344718
   
  
• A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo.
  Prakash N, Brodski C, Naserke T, Puelles E, Gogoi R, Hall A, Panhuysen M, Echevarria D, Sussel L, Weisenhorn DM, Martinez S, Arenas E, Simeone A, Wurst W
  Development. 2006
  PubMed ID: 16339193
   
  
• Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes.
  Rodríguez S, Gaunt TR, Dennison E, Chen XH, Syddall HE, Phillips DI, Cooper C, Day IN
  Eur J Hum Genet. 2006
  PubMed ID: 16251897
   
  
• Reciprocal gene replacements reveal unique functions for Phox2 genes during neural differentiation.
  Coppola E, Pattyn A, Guthrie SC, Goridis C, Studer M
  EMBO J. 2005
  PubMed ID: 16319924
   
  
• Molecular genetics of tyrosine 3-monooxygenase and inherited diseases.
  Kobayashi K, Nagatsu T
  Biochem Biophys Res Commun. 2005
  PubMed ID: 16105653
   
  
• p63 is an essential proapoptotic protein during neural development.
  Jacobs WB, Govoni G, Ho D, Atwal JK, Barnabe-Heider F, Keyes WM, Mills AA, Miller FD, Kaplan DR
  Neuron. 2005
  PubMed ID: 16337913
   
  
• The assays of activities and function of TH, AADC, and GCH1 and their potential use in ex vivo gene therapy of PD.
  Duan CL, Su Y, Zhao CL, Lu LL, Xu QY, Yang H
  Brain Res Brain Res Protoc. 2005
  PubMed ID: 16338639
   
  
• Dysregulation of dopamine signaling in the dorsal striatum inhibits feeding.
  Sotak BN, Hnasko TS, Robinson S, Kremer EJ, Palmiter RD
  Brain Res. 2005
  PubMed ID: 16226228
   
  
• Butyrate, a gut-derived environmental signal, regulates tyrosine hydroxylase gene expression via a novel promoter element.
  Patel P, Nankova BB, LaGamma EF
  Brain Res Dev Brain Res. 2005
  PubMed ID: 16165221
   
  
• Ethanol consumption increases rat stress hormones and adrenomedullary gene expression.
  Patterson-Buckendahl P, Kubovcakova L, Krizanova O, Pohorecky LA, Kvetnansky R
  Alcohol. 2005
  PubMed ID: 16713504
   
  
• Ret deficiency in mice impairs the development of A5 and A6 neurons and the functional maturation of the respiratory rhythm.
  Viemari JC, Maussion G, Bévengut M, Burnet H, Pequignot JM, Népote V, Pachnis V, Simonneau M, Hilaire G
  Eur J Neurosci. 2005
  PubMed ID: 16307583
   
  
• Ontogeny of tyrosine hydroxylase mRNA expression in mid- and forebrain: neuromeric pattern and novel positive regions.
  Marín F, Herrero MT, Vyas S, Puelles L
  Dev Dyn. 2005
  PubMed ID: 15973733
   
  
• DNA polymorphisms in the tyrosine hydroxylase and GNB3 genes: association with unexpected death from acute myocardial infarction and increased heart weight.
  Klintschar M, Stiller D, Schwaiger P, Kleiber M
  Forensic Sci Int. 2005
  PubMed ID: 16139102
   
  
• Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo.
  Hasbani DM, Perez FA, Palmiter RD, O'Malley KL
  J Neurosci. 2005
  PubMed ID: 16221852
   
  
• Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum.
  Wang VY, Rose MF, Zoghbi HY
  Neuron. 2005
  PubMed ID: 16202707
   
  
• Lack of an adrenal cortex in Sf1 mutant mice is compatible with the generation and differentiation of chromaffin cells.
  Gut P, Huber K, Lohr J, Brühl B, Oberle S, Treier M, Ernsberger U, Kalcheim C, Unsicker K
  Development. 2005
  PubMed ID: 16176945
   
  
• Notch signaling coordinates the patterning of striatal compartments.
  Mason HA, Rakowiecki SM, Raftopoulou M, Nery S, Huang Y, Gridley T, Fishell G
  Development. 2005
  PubMed ID: 16120638
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Runx1 expression defines a subpopulation of displaced amacrine cells in the developing mouse retina.
  Stewart L, Potok MA, Camper SA, Stifani S
  J Neurochem. 2005
  PubMed ID: 16026391
   
  
• Tyrosine hydroxylase in rat auditory midbrain: distribution and changes following deafness.
  Tong L, Altschuler RA, Holt AG
  Hear Res. 2005
  PubMed ID: 16080996
   
  
• Dehydroepiandrosterone sulfate and allopregnanolone directly stimulate catecholamine production via induction of tyrosine hydroxylase and secretion by affecting actin polymerization.
  Charalampopoulos I, Dermitzaki E, Vardouli L, Tsatsanis C, Stournaras C, Margioris AN, Gravanis A
  Endocrinology. 2005
  PubMed ID: 15860555
   
  
• Characterization of five evolutionary conserved regions of the human tyrosine hydroxylase (TH) promoter: implications for the engineering of a human TH minimal promoter assembled in a self-inactivating lentiviral vector system.
  Romano G, Suon S, Jin H, Donaldson AE, Iacovitti L
  J Cell Physiol. 2005
  PubMed ID: 15744773
   
  
• Developmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdin.
  Pagliardini S, Ren J, Wevrick R, Greer JJ
  Am J Pathol. 2005
  PubMed ID: 15972963
   
  
• The tissue-specific methylation of the human tyrosine hydroxylase gene reveals new regulatory elements in the first exon.
  Arányi T, Faucheux BA, Khalfallah O, Vodjdani G, Biguet NF, Mallet J, Meloni R
  J Neurochem. 2005
  PubMed ID: 15953356
   
  
• Deletion of N-terminus of human tyrosine hydroxylase type 1 enhances stability of the enzyme in AtT-20 cells.
  Nakashima A, Hayashi N, Kaneko YS, Mori K, Egusa H, Nagatsu T, Ota A
  J Neurosci Res. 2005
  PubMed ID: 15898085
   
  
• Mash1 is required for glomus cell formation in the mouse carotid body.
  Kameda Y
  Dev Biol. 2005
  PubMed ID: 15878769
   
  
• Prenatal morphine exposure affects sympathoadrenal axis activity and serotonin metabolism in adult male rats both under basal conditions and after an ether inhalation stress.
  Laborie C, Dutriez-Casteloot I, Montel V, Dickès-Coopman A, Lesage J, Vieau D
  Neurosci Lett. 2005
  PubMed ID: 15896472
   
  
• Pitx3 regulates tyrosine hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development.
  Maxwell SL, Ho HY, Kuehner E, Zhao S, Li M
  Dev Biol. 2005
  PubMed ID: 15950611
   
  
• Transcriptional regulation of tyrosine hydroxylase by estrogen: opposite effects with estrogen receptors alpha and beta and interactions with cyclic AMP.
  Maharjan S, Serova L, Sabban EL
  J Neurochem. 2005
  PubMed ID: 15935066
   
  
• Levodopa-responsive infantile parkinsonism due to a novel mutation in the tyrosine hydroxylase gene and exacerbation by viral infections.
  Diepold K, Schütz B, Rostasy K, Wilken B, Hougaard P, Güttler F, Romstad A, Birk Møller L
  Mov Disord. 2005
  PubMed ID: 15747353
   
  
• Urocortin 2 induces tyrosine hydroxylase phosphorylation in PC12 cells.
  Nemoto T, Mano-Otagiri A, Shibasaki T
  Biochem Biophys Res Commun. 2005
  PubMed ID: 15809070
   
  
• Decreased tyrosine hydroxylase activity in the adrenals of spontaneously hypertensive rats.
  Moura E, Pinho Costa PM, Moura D, Guimarães S, Vieira-Coelho MA
  Life Sci. 2005
  PubMed ID: 15820506
   
  
• Influences of dopaminergic lesion on epidermal growth factor-ErbB signals in Parkinson's disease and its model: neurotrophic implication in nigrostriatal neurons.
  Iwakura Y, Piao YS, Mizuno M, Takei N, Kakita A, Takahashi H, Nawa H
  J Neurochem. 2005
  PubMed ID: 15857400
   
  
• Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives.
  Engleka KA, Gitler AD, Zhang M, Zhou DD, High FA, Epstein JA
  Dev Biol. 2005
  PubMed ID: 15882581
   
  
• CAPS1 regulates catecholamine loading of large dense-core vesicles.
  Speidel D, Bruederle CE, Enk C, Voets T, Varoqueaux F, Reim K, Becherer U, Fornai F, Ruggieri S, Holighaus Y, Weihe E, Bruns D, Brose N, Rettig J
  Neuron. 2005
  PubMed ID: 15820695
   
  
• Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance.
  Suto F, Ito K, Uemura M, Shimizu M, Shinkawa Y, Sanbo M, Shinoda T, Tsuboi M, Takashima S, Yagi T, Fujisawa H
  J Neurosci. 2005
  PubMed ID: 15814794
   
  
• NPY and TH innervation in human choroidal whole-mounts.
  Triviño A, de Hoz R, Rojas B, Salazar JJ, Ramirez AI, Ramirez JM
  Histol Histopathol. 2005
  PubMed ID: 15736042
   
  
• The role of Phox2B in chromaffin cell development.
  Huber K, Karch N, Ernsberger U, Goridis C, Unsicker K
  Dev Biol. 2005
  PubMed ID: 15733675
   
  
• Monoaminergic neuronal development is not affected in PACAP-gene-deficient mice.
  Ogawa T, Nakamachi T, Ohtaki H, Hashimoto H, N S, Baba A, Watanabe J, Kikuyama S, Shioda S
  Regul Pept. 2005
  PubMed ID: 15620422
   
  
• Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception.
  Warnecke M, Oster H, Revelli JP, Alvarez-Bolado G, Eichele G
  Genes Dev. 2005
  PubMed ID: 15741322
   
  
• Tyrosine hydroxylase Val-81-Met polymorphism associated with early-onset alcoholism.
  Dahmen N, Völp M, Singer P, Hiemke C, Szegedi A
  Psychiatr Genet. 2005
  PubMed ID: 15722952
   
  
• Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth.
  Lee S, Walker CL, Karten B, Kuny SL, Tennese AA, O'Neill MA, Wevrick R
  Hum Mol Genet. 2005
  PubMed ID: 15649943
   
  
• Mutation of regulatory serines of rat tyrosine hydroxylase to glutamate: effects on enzyme stability and activity.
  Royo M, Fitzpatrick PF, Daubner SC
  Arch Biochem Biophys. 2005
  PubMed ID: 15639226
   
  
• Expression of the neuronal calcium sensor protein NCS-1 in the developing mouse olfactory pathway.
  Treloar HB, Uboha U, Jeromin A, Greer CA
  J Comp Neurol. 2005
  PubMed ID: 15611992
   
  
• Arx homeobox gene is essential for development of mouse olfactory system.
  Yoshihara S, Omichi K, Yanazawa M, Kitamura K, Yoshihara Y
  Development. 2005
  PubMed ID: 15677725
   
  
• Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.
  Jiang Z, Dalton TP, Jin L, Wang B, Tsuneoka Y, Shertzer HG, Deka R, Nebert DW
  Hum Mutat. 2005
  PubMed ID: 15643613
   
  
• MPTP treatment impairs tyrosine hydroxylase immunopositive fibers not only in the striatum, but also in the amygdala.
  von Bohlen und Halbach O, Schober A, Hertel R, Unsicker K
  Neurodegener Dis. 2005
  PubMed ID: 16909002
   
  
• Inverse blood pressure rhythm of transgenic hypertensive TGR(mREN2)27 rats: role of norepinephrine and expression of tyrosine-hydroxylase and reuptake1-transporter.
  Lemmer B, Schiffer S, Witte K, Gorbey S
  Chronobiol Int. 2005
  PubMed ID: 16076648
   
  
• TH01, a tetrameric short tandem repeat locus in the tyrosine hydroxylase gene: association with myocardial hypertrophy and death from myocardial infarction?
  Klintschar M, Immel UD, Stiller D, Kleiber M
  Dis Markers. 2005
  PubMed ID: 15735319
   
  
• Upregulation of neuronal nitric oxide synthase mRNA and protein in adrenal medulla of water-deprived rats.
  Lai FJ, Huang SS, Hsieh MC, Hsin SC, Wu CH, Hsin YC, Shin SJ
  J Histochem Cytochem. 2005
  PubMed ID: 15637337
   
  
• Engrailed genes control developmental fate of serotonergic and noradrenergic neurons in mid- and hindbrain in a gene dose-dependent manner.
  Simon HH, Scholz C, O'Leary DD
  Mol Cell Neurosci. 2005
  PubMed ID: 15607945
   
  
• Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator.
  Keegan CE, Hutz JE, Else T, Adamska M, Shah SP, Kent AE, Howes JM, Beamer WG, Hammer GD
  Hum Mol Genet. 2005
  PubMed ID: 15537664
   
  
• Effects of mutations in tyrosine hydroxylase associated with progressive dystonia on the activity and stability of the protein.
  Royo M, Daubner SC, Fitzpatrick PF
  Proteins. 2005
  PubMed ID: 15468323
   
  
• Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability.
  Moy LY, Tsai LH
  J Biol Chem. 2004
  PubMed ID: 15471880
   
  
• Defective postnatal neurogenesis and disorganization of the rostral migratory stream in absence of the Vax1 homeobox gene.
  Soria JM, Taglialatela P, Gil-Perotin S, Galli R, Gritti A, Verdugo JM, Bertuzzi S
  J Neurosci. 2004
  PubMed ID: 15590934
   
  
• Transient expression of tyrosine hydroxylase promoter/reporter gene constructs in the olfactory epithelium of transgenic mice.
  Sasaki H, Berlin R, Baker H
  J Neurocytol. 2004
  PubMed ID: 16217623
   
  
• Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral corr
  Sun M, Kong L, Wang X, Holmes C, Gao Q, Zhang GR, Pfeilschifter J, Goldstein DS, Geller AI
  Hum Gene Ther. 2004
  PubMed ID: 15684695
   
  
• The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta.
  Thuret S, Alavian KN, Gassmann M, Lloyd CK, Smits SM, Smidt MP, Klein R, Dyck RH, Simon HH
  J Neurochem. 2004
  PubMed ID: 15584907
   
  
• Fibroblast growth factor-20 promotes the differentiation of Nurr1-overexpressing neural stem cells into tyrosine hydroxylase-positive neurons.
  Grothe C, Timmer M, Scholz T, Winkler C, Nikkhah G, Claus P, Itoh N, Arenas E
  Neurobiol Dis. 2004
  PubMed ID: 15474354
   
  
• A role for dopamine in feeding responses produced by orexigenic agents.
  Hnasko TS, Szczypka MS, Alaynick WA, During MJ, Palmiter RD
  Brain Res. 2004
  PubMed ID: 15374756
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• [TH gene mutation in Chinese patients with autosomal recessive dopa-responsive dystonia]
  Liu W, Tang BS, Cao GF, Chen T, Li HY
  Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004
  PubMed ID: 15476168
   
  
• Transgenic expression of Cre recombinase from the tyrosine hydroxylase locus.
  Lindeberg J, Usoskin D, Bengtsson H, Gustafsson A, Kylberg A, Söderström S, Ebendal T
  Genesis. 2004
  PubMed ID: 15452869
   
  
• Identification of tyrosine hydroxylase as a physiological substrate for Cdk5.
  Kansy JW, Daubner SC, Nishi A, Sotogaku N, Lloyd MD, Nguyen C, Lu L, Haycock JW, Hope BT, Fitzpatrick PF, Bibb JA
  J Neurochem. 2004
  PubMed ID: 15447670
   
  
• Essential role of Gata transcription factors in sympathetic neuron development.
  Tsarovina K, Pattyn A, Stubbusch J, Müller F, van der Wees J, Schneider C, Brunet JF, Rohrer H
  Development. 2004
  PubMed ID: 15329349
   
  
• Firing properties of dopamine neurons in freely moving dopamine-deficient mice: effects of dopamine receptor activation and anesthesia.
  Robinson S, Smith DM, Mizumori SJ, Palmiter RD
  Proc Natl Acad Sci U S A. 2004
  PubMed ID: 15317940
   
  
• Isoosmotic isolation of rat brain synaptic vesicles, some of which contain tyrosine hydroxylase.
  Tsudzuki T, Tsujita M
  J Biochem. 2004
  PubMed ID: 15496595
   
  
• Analytical characterization of a sensitive radioassay for tyrosine hydroxylase activity in rodent striatum.
  Khan HA
  Neurochem Res. 2004
  PubMed ID: 15260122
   
  
• Coordinated regulation of gene expression by Brn3a in developing sensory ganglia.
  Eng SR, Lanier J, Fedtsova N, Turner EE
  Development. 2004
  PubMed ID: 15253936
   
  
• EphA receptors direct the differentiation of mammalian neural precursor cells through a mitogen-activated protein kinase-dependent pathway.
  Aoki M, Yamashita T, Tohyama M
  J Biol Chem. 2004
  PubMed ID: 15145949
   
  
• Response of tyrosine hydroxylase and GTP cyclohydrolase I gene expression to estrogen in brain catecholaminergic regions varies with mode of administration.
  Serova LI, Maharjan S, Huang A, Sun D, Kaley G, Sabban EL
  Brain Res. 2004
  PubMed ID: 15223360
   
  
• AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons.
  Theriault FM, Roy P, Stifani S
  Proc Natl Acad Sci U S A. 2004
  PubMed ID: 15240886
   
  
• c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice.
  Burau K, Stenull I, Huber K, Misawa H, Berse B, Unsicker K, Ernsberger U
  Eur J Neurosci. 2004
  PubMed ID: 15233745
   
  
• Engrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons.
  Albéri L, Sgadò P, Simon HH
  Development. 2004
  PubMed ID: 15175251
   
  
• Presenilin 1 in migration and morphogenesis in the central nervous system.
  Louvi A, Sisodia SS, Grove EA
  Development. 2004
  PubMed ID: 15163631
   
  
• Caspase-3 and caspase-9 mediate developmental apoptosis in the mouse olfactory system.
  Cowan CM, Roskams AJ
  J Comp Neurol. 2004
  PubMed ID: 15156583
   
  
• Different stabilities and denaturation pathways for structurally related aromatic amino acid hydroxylases.
  Kleppe R, Haavik J
  FEBS Lett. 2004
  PubMed ID: 15135070
   
  
• The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction.
  Bolon B, Jing S, Asuncion F, Scully S, Pisegna M, Van GY, Hu Z, Yu YB, Min H, Wild K, Rosenfeld RD, Tarpley J, Carnahan J, Duryea D, Hill D, Kaufman S, Yan XQ, Juan T, Christensen K, McCabe J, Simonet WS
  Toxicol Pathol. 2004
  PubMed ID: 15204970
   
  
• Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain.
  Puelles E, Annino A, Tuorto F, Usiello A, Acampora D, Czerny T, Brodski C, Ang SL, Wurst W, Simeone A
  Development. 2004
  PubMed ID: 15105370
   
  
• Stereospecific regulation of tyrosine hydroxylase and proenkephalin genes by short-chain fatty acids in rat PC12 cells.
  Mally P, Mishra R, Gandhi S, Decastro MH, Nankova BB, Lagamma EF
  Pediatr Res. 2004
  PubMed ID: 14739357
   
  
• Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase.
  Kobayashi K, Takahashi M, Matsushita N, Miyazaki J, Koike M, Yaginuma H, Osumi N, Kaibuchi K, Kobayashi K
  J Neurosci. 2004
  PubMed ID: 15071095
   
  
• Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression.
  Ieda M, Fukuda K, Hisaka Y, Kimura K, Kawaguchi H, Fujita J, Shimoda K, Takeshita E, Okano H, Kurihara Y, Kurihara H, Ishida J, Fukamizu A, Federoff HJ, Ogawa S
  J Clin Invest. 2004
  PubMed ID: 15067320
   
  
• Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.
  Thuret S, Bhatt L, O'Leary DD, Simon HH
  Mol Cell Neurosci. 2004
  PubMed ID: 15033168
   
  
• Abnormal expression of tyrosine hydroxylase not accompanied by phosphorylation at serine 40 in cerebellar Purkinje cells of ataxic mutant mice, rolling mouse Nagoya and dilute-lethal.
  Sawada K, Ando M, Sakata-Haga H, Sun XZ, Jeong YG, Hisano S, Takeda N, Fukui Y
  Congenit Anom (Kyoto). 2004
  PubMed ID: 15008900
   
  
• Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection.
  Wang SS, Lewcock JW, Feinstein P, Mombaerts P, Reed RR
  Development. 2004
  PubMed ID: 14993187
   
  
• PITX2 is required for normal development of neurons in the mouse subthalamic nucleus and midbrain.
  Martin DM, Skidmore JM, Philips ST, Vieira C, Gage PJ, Condie BG, Raphael Y, Martinez S, Camper SA
  Dev Biol. 2004
  PubMed ID: 14975719
   
  
• Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3.
  Smidt MP, Smits SM, Bouwmeester H, Hamers FP, van der Linden AJ, Hellemons AJ, Graw J, Burbach JP
  Development. 2004
  PubMed ID: 14973278
   
  
• Expression of a member of tumor necrosis factor receptor superfamily, TROY, in the developing olfactory system.
  Hisaoka T, Morikawa Y, Kitamura T, Senba E
  Glia. 2004
  PubMed ID: 14966863
   
  
• Nicotine dependence in a prospective population-based study of adolescents: the protective role of a functional tyrosine hydroxylase polymorphism.
  Anney RJ, Olsson CA, Lotfi-Miri M, Patton GC, Williamson R
  Pharmacogenetics. 2004
  PubMed ID: 15077008
   
  
• Heterogeneous requirement of NGF for sympathetic target innervation in vivo.
  Glebova NO, Ginty DD
  J Neurosci. 2004
  PubMed ID: 14736860
   
  
• Central angiotensin II increases biosynthesis of tyrosine hydroxylase in the rat adrenal medulla.
  Dogan MD, Sumners C, Broxson CS, Clark N, Tümer N
  Biochem Biophys Res Commun. 2004
  PubMed ID: 14697237
   
  
• Enhancement of tyrosine hydroxylase phosphorylation and activity by glial cell line-derived neurotrophic factor.
  Kobori N, Waymire JC, Haycock JW, Clifton GL, Dash PK
  J Biol Chem. 2004
  PubMed ID: 14570886
   
  
• Regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum.
  Mengual E, Pickel VM
  J Comp Neurol. 2004
  PubMed ID: 14681933
   
  
• The role of dopamine in learning, memory, and performance of a water escape task.
  Denenberg VH, Kim DS, Palmiter RD
  Behav Brain Res. 2004
  PubMed ID: 14684249
   
  
• Social hierarchy affects gene expression for catecholamine biosynthetic enzymes in rat adrenal glands.
  Pohorecky LA, Blakley GG, Kubovcakova L, Krizanova O, Patterson-Buckendahl P, Kvetnansky R
  Neuroendocrinology. 2004
  PubMed ID: 15345906
   
  
• Association between dependent smoking and a polymorphism in the tyrosine hydroxylase gene in a prospective population-based study of adolescent health.
  Olsson C, Anney R, Forrest S, Patton G, Coffey C, Cameron T, Hassett A, Williamson R
  Behav Genet. 2004
  PubMed ID: 14739699
   
  
• Cyclin-dependent kinase 11p110 and casein kinase 2 (CK2) inhibit the interaction between tyrosine hydroxylase and 14-3-3.
  Sachs NA, Vaillancourt RR
  J Neurochem. 2004
  PubMed ID: 14675149
   
  
• Cloning and cell type-specific regulation of the human tyrosine hydroxylase gene promoter.
  Kim TE, Park MJ, Choi EJ, Lee HS, Lee SH, Yoon SH, Oh CK, Lee BJ, Kim SU, Lee YS, Lee MA
  Biochem Biophys Res Commun. 2003
  PubMed ID: 14651989
   
  
• Regulation of the tyrosine hydroxylase gene promoter by histone deacetylase inhibitors.
  Kim HS, Park JS, Hong SJ, Woo MS, Kim SY, Kim KS
  Biochem Biophys Res Commun. 2003
  PubMed ID: 14651963
   
  
• p57(Kip2) cooperates with Nurr1 in developing dopamine cells.
  Joseph B, Wallén-Mackenzie A, Benoit G, Murata T, Joodmardi E, Okret S, Perlmann T
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 14671317
   
  
• Quantitative genetic analysis of ventral midbrain and liver iron in BXD recombinant inbred mice.
  Jones BC, Reed CL, Hitzemann R, Wiesinger JA, McCarthy KA, Buwen JP, Beard JL
  Nutr Neurosci. 2003
  PubMed ID: 14744041
   
  
• Effects of acute, repeated and chronic variable stress on in vivo tyrosine hydroxylase activity and on alpha(2)-adrenoceptor sensitivity in the rat brain.
  Prieto M, Gómez FM, Teresa Giralt M
  Stress. 2003
  PubMed ID: 14660060
   
  
• Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation.
  Simon R, Lufkin T
  Mol Cell Biol. 2003
  PubMed ID: 14645517
   
  
• Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways.
  Dauger S, Pattyn A, Lofaso F, Gaultier C, Goridis C, Gallego J, Brunet JF
  Development. 2003
  PubMed ID: 14627719
   
  
• Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development.
  Nishida A, Furukawa A, Koike C, Tano Y, Aizawa S, Matsuo I, Furukawa T
  Nat Neurosci. 2003
  PubMed ID: 14625556
   
  
• Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons.
  Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, Bhatnagar A, Meloni EG, Wu N, Ackerson LC, Klapstein GJ, Gajendiran M, Roth BL, Chesselet MF, Maidment NT, Levine MS, Shen J
  J Biol Chem. 2003
  PubMed ID: 12930822
   
  
• Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a.
  Castelo-Branco G, Wagner J, Rodriguez FJ, Kele J, Sousa K, Rawal N, Pasolli HA, Fuchs E, Kitajewski J, Arenas E
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 14557550
   
  
• Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons.
  Smits SM, Ponnio T, Conneely OM, Burbach JP, Smidt MP
  Eur J Neurosci. 2003
  PubMed ID: 14622207
   
  
• Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells.
  Hermanson E, Joseph B, Castro D, Lindqvist E, Aarnisalo P, Wallén A, Benoit G, Hengerer B, Olson L, Perlmann T
  Exp Cell Res. 2003
  PubMed ID: 12915123
   
  
• Transgenic mice engineered to target Cre/loxP-mediated DNA recombination into catecholaminergic neurons.
  Gelman DM, Noaín D, Avale ME, Otero V, Low MJ, Rubinstein M
  Genesis. 2003
  PubMed ID: 12929090
   
  
• Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons.
  Holm PC, Rodríguez FJ, Kresse A, Canals JM, Silos-Santiago I, Arenas E
  Development. 2003
  PubMed ID: 12810600
   
  
• Activation of tyrosine hydroxylase by intermittent hypoxia: involvement of serine phosphorylation.
  Kumar GK, Kim DK, Lee MS, Ramachandran R, Prabhakar NR
  J Appl Physiol. 2003
  PubMed ID: 12692140
   
  
• Tyrosinase: a developmentally specific major determinant of peripheral dopamine.
  Eisenhofer G, Tian H, Holmes C, Matsunaga J, Roffler-Tarlov S, Hearing VJ
  FASEB J. 2003
  PubMed ID: 12832289
   
  
• Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1.
  Kawano H, Horie M, Honma S, Kawamura K, Takeuchi K, Kimura S
  Exp Neurol. 2003
  PubMed ID: 12821380
   
  
• Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina.
  de Melo J, Qiu X, Du G, Cristante L, Eisenstat DD
  J Comp Neurol. 2003
  PubMed ID: 12724837
   
  
• Lack of Reelin causes malpositioning of nigral dopaminergic neurons: evidence from comparison of normal and Reln(rl) mutant mice.
  Nishikawa S, Goto S, Yamada K, Hamasaki T, Ushio Y
  J Comp Neurol. 2003
  PubMed ID: 12724835
   
  
• Patterning of the lateral ganglionic eminence by the Gsh1 and Gsh2 homeobox genes regulates striatal and olfactory bulb histogenesis and the growth of axons through the basal ganglia.
  Yun K, Garel S, Fischman S, Rubenstein JL
  J Comp Neurol. 2003
  PubMed ID: 12724834
   
  
• The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum.
  Chi CL, Martinez S, Wurst W, Martin GR
  Development. 2003
  PubMed ID: 12736208
   
  
• Catecholamines act via a beta-adrenergic receptor to maintain fetal heart rate and survival.
  Portbury AL, Chandra R, Groelle M, McMillian MK, Elias A, Herlong JR, Rios M, Roffler-Tarlov S, Chikaraishi DM
  Am J Physiol Heart Circ Physiol. 2003
  PubMed ID: 12574001
   
  
• Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer.
  Brodski C, Weisenhorn DM, Signore M, Sillaber I, Oesterheld M, Broccoli V, Acampora D, Simeone A, Wurst W
  J Neurosci. 2003
  PubMed ID: 12764108
   
  
• Normal nigrostriatal innervation but dopamine dysfunction in mice carrying hypomorphic tyrosine hydroxylase alleles.
  Althini S, Bengtsson H, Usoskin D, Söderström S, Kylberg A, Lindqvist E, Chuva de Sousa Lopes S, Olson L, Lindeberg J, Ebendal T
  J Neurosci Res. 2003
  PubMed ID: 12704806
   
  
• Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus.
  Andrews GL, Yun K, Rubenstein JL, Mastick GS
  Mol Cell Neurosci. 2003
  PubMed ID: 12799141
   
  
• Angiotensin II AT(1) and AT(2) receptors contribute to maintain basal adrenomedullary norepinephrine synthesis and tyrosine hydroxylase transcription.
  Jezova M, Armando I, Bregonzio C, Yu ZX, Qian S, Ferrans VJ, Imboden H, Saavedra JM
  Endocrinology. 2003
  PubMed ID: 12697718
   
  
• Tyrosine hydroxylase and norepinephrine transporter in sympathetic ganglia of female rats vary with reproductive state.
  Anglin JC, Brooks VL
  Auton Neurosci. 2003
  PubMed ID: 12742186
   
  
• FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals.
  Trokovic R, Trokovic N, Hernesniemi S, Pirvola U, Vogt Weisenhorn DM, Rossant J, McMahon AP, Wurst W, Partanen J
  EMBO J. 2003
  PubMed ID: 12682014
   
  
• The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouse.
  Levi G, Puche AC, Mantero S, Barbieri O, Trombino S, Paleari L, Egeo A, Merlo GR
  Mol Cell Neurosci. 2003
  PubMed ID: 12727448
   
  
• Dopamine modulates cell cycle in the lateral ganglionic eminence.
  Ohtani N, Goto T, Waeber C, Bhide PG
  J Neurosci. 2003
  PubMed ID: 12684471
   
  
• Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors.
  Schnell PO, Ignacak ML, Bauer AL, Striet JB, Paulding WR, Czyzyk-Krzeska MF
  J Neurochem. 2003
  PubMed ID: 12675925
   
  
• Effect of novel stressors on tyrosine hydroxylase gene expression in the adrenal medulla of repeatedly immobilized rats.
  Kvetnansky R, Rusnak M, Dronjak S, Krizanova O, Sabban EL
  Neurochem Res. 2003
  PubMed ID: 12675153
   
  
• Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism.
  Paladini CA, Robinson S, Morikawa H, Williams JT, Palmiter RD
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 12604788
   
  
• Determination of retinal cell fates is affected in the absence of extraocular striated muscles.
  Kablar B
  Dev Dyn. 2003
  PubMed ID: 12619134
   
  
• Development of adrenal chromaffin cells is largely normal in mice lacking the receptor tyrosine kinase c-Ret.
  Allmendinger A, Stoeckel E, Saarma M, Unsicker K, Huber K
  Mech Dev. 2003
  PubMed ID: 12591599
   
  
• Different populations of tyrosine-hydroxylase-immunoreactive neurons defined by differential expression of nitric oxide synthase in the human temporal cortex.
  Benavides-Piccione R, DeFelipe J
  Cereb Cortex. 2003
  PubMed ID: 12571119
   
  
• Long-term gonadectomy affects the density of tyrosine hydroxylase- but not dopamine-beta-hydroxylase-, choline acetyltransferase- or serotonin-immunoreactive axons in the medial prefrontal cortices of adult male rats.
  Kritzer MF
  Cereb Cortex. 2003
  PubMed ID: 12571118
   
  
• Estrogen regulates tyrosine hydroxylase expression in the neonate mouse midbrain.
  Ivanova T, Beyer C
  J Neurobiol. 2003
  PubMed ID: 12555275
   
  
• Adenosine receptor blockade reverses hypophagia and enhances locomotor activity of dopamine-deficient mice.
  Kim DS, Palmiter RD
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 12538862
   
  
• Tyrosine hydroxylase isoenzyme I is present in human melanosomes: a possible novel function in pigmentation.
  Marles LK, Peters EM, Tobin DJ, Hibberts NA, Schallreuter KU
  Exp Dermatol. 2003
  PubMed ID: 12631248
   
  
• Age-related decline in the tyrosine hydroxylase-immunoreactive innervation of the amygdala and dentate gyrus in mice.
  von Bohlen und Halbach O, Unsicker K
  Cell Tissue Res. 2003
  PubMed ID: 12596034
   
  
• Real-time analysis of tyrosine hydroxylase gene expression: a sensitive and semiquantitative marker for minimal residual disease detection of neuroblastoma.
  Lambooy LH, Gidding CE, van den Heuvel LP, Hulsbergen-van de Kaa CA, Ligtenberg M, Bökkerink JP, De Abreu RA
  Clin Cancer Res. 2003
  PubMed ID: 12576454
   
  
• Polymorphism of the insulin gene is associated with increased prostate cancer risk.
  Ho GY, Melman A, Liu SM, Li M, Yu H, Negassa A, Burk RD, Hsing AW, Ghavamian R, Chua SC
  Br J Cancer. 2003
  PubMed ID: 12610512
   
  
• DLX5 regulates development of peripheral and central components of the olfactory system.
  Long JE, Garel S, Depew MJ, Tobet S, Rubenstein JL
  J Neurosci. 2003
  PubMed ID: 12533617
   
  
• New splicing variants for human Tyrosine Hydroxylase gene with possible implications for the detection of minimal residual disease in patients with neuroblastoma.
  Parareda A, Villaescusa JC, Sanchez de Toledo J, Gallego S
  Neurosci Lett. 2003
  PubMed ID: 12493595
   
  
• Regulation of tyrosine hydroxylase expression in tottering mouse Purkinje cells.
  Fureman BE, Campbell DB, Hess EJ
  Neurotox Res. 2003
  PubMed ID: 14715436
   
  
• Tyrosine hydroxylase deficiency causes progressive encephalopathy and dopa-nonresponsive dystonia.
  Hoffmann GF, Assmann B, Bräutigam C, Dionisi-Vici C, Häussler M, de Klerk JB, Naumann M, Steenbergen-Spanjers GC, Strassburg HM, Wevers RA
  Ann Neurol. 2003
  PubMed ID: 12891655
   
  
• VNTR polymorphism of tyrosine hydroxylase gene and schizophrenia in the Korean population.
  Pae CU, Kim JJ, Serretti A, Lee CU, Lee SJ, Lee C, Paik IH
  Neuropsychobiology. 2003
  PubMed ID: 12759555
   
  
• Polymorphisms of the tyrosine hydroxylase gene in subjects susceptible to high-altitude pulmonary edema.
  Hanaoka M, Droma Y, Hotta J, Matsuzawa Y, Kobayashi T, Kubo K, Ota M
  Chest. 2003
  PubMed ID: 12527603
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH.
  Mahy NL, Perry PE, Bickmore WA
  J Cell Biol. 2002
  PubMed ID: 12473685
   
  
• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
  Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
  Nature. 2002
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• Modulation of olfactory bulb tyrosine hydroxylase and catecholamine transporter mRNA by estrogen.
  Dluzen DE, Park JH, Kim K
  Brain Res Mol Brain Res. 2002
  PubMed ID: 12480184
   
  
• Ultrastructural localization of tyrosine hydroxylase in human peripheral blood mononuclear cells: effect of stimulation with phytohaemagglutinin.
  Reguzzoni M, Cosentino M, Rasini E, Marino F, Ferrari M, Bombelli R, Congiu T, Protasoni M, Quacci D, Lecchini S, Raspanti M, Frigo G
  Cell Tissue Res. 2002
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• A role for midbrain arcs in nucleogenesis.
  Agarwala S, Ragsdale CW
  Development. 2002
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• Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40.
  Simon AM, McWhorter AR
  Dev Biol. 2002
  PubMed ID: 12435353
   
  
• Information provided by the skeletal muscle and associated neurons is necessary for proper brain development.
  Kablar B, Rudnicki MA
  Int J Dev Neurosci. 2002
  PubMed ID: 12485625
   
  
• Regulation of tyrosine hydroxylase by stress-activated protein kinases.
  Toska K, Kleppe R, Armstrong CG, Morrice NA, Cohen P, Haavik J
  J Neurochem. 2002
  PubMed ID: 12421349
   
  
• Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1.
  Fitzpatrick GV, Soloway PD, Higgins MJ
  Nat Genet. 2002
  PubMed ID: 12410230
   
  
• Perinatal nicotine attenuates the hypoxia-induced up-regulation of tyrosine hydroxylase and galanin mRNA in locus ceruleus of the newborn mouse.
  Wickström HR, Mas C, Simonneau M, Holgert H, Hökfelt T, Lagercrantz H
  Pediatr Res. 2002
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• Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene.
  Suzuki T, Yamakuni T, Hagiwara M, Ichinose H
  J Biol Chem. 2002
  PubMed ID: 12196528
   
  
• Murine Lix1, a novel marker for substantia nigra, cortical layer 5, and hindbrain structures.
  Moeller C, Yaylaoglu MB, Alvarez-Bolado G, Thaller C, Eichele G
  Brain Res Gene Expr Patterns. 2002
  PubMed ID: 12638132
   
  
• Post-genomic era and gene discovery for psychiatric diseases: there is a new art of the trade? The example of the HUMTH01 microsatellite in the Tyrosine Hydroxylase gene.
  Meloni R, Biguet NF, Mallet J
  Mol Neurobiol. 2002
  PubMed ID: 12428766
   
  
• Galanin inhibits tyrosine hydroxylase expression in midbrain dopaminergic neurons.
  Counts SE, McGuire SO, Sortwell CE, Crawley JN, Collier TJ, Mufson EJ
  J Neurochem. 2002
  PubMed ID: 12423254
   
  
• Development of chromaffin cells depends on MASH1 function.
  Huber K, Brühl B, Guillemot F, Olson EN, Ernsberger U, Unsicker K
  Development. 2002
  PubMed ID: 12361965
   
  
• Frizzled-3 is required for the development of major fiber tracts in the rostral CNS.
  Wang Y, Thekdi N, Smallwood PM, Macke JP, Nathans J
  J Neurosci. 2002
  PubMed ID: 12351730
   
  
• Expression of estrogen receptor-alpha and cFos in norepinephrine and epinephrine neurons of young and middle-aged rats during the steroid-induced luteinizing hormone surge.
  Temel S, Lin W, Lakhlani S, Jennes L
  Endocrinology. 2002
  PubMed ID: 12239109
   
  
• Glial cell line-derived neurotrophic factor up-regulates the expression of tyrosine hydroxylase gene in human neuroblastoma cell lines.
  Xiao H, Hirata Y, Isobe K, Kiuchi K
  J Neurochem. 2002
  PubMed ID: 12358785
   
  
• Gender differences in hypothalamic tyrosine hydroxylase and alpha(2)-adrenoceptor subtype gene expression in cafeteria diet-induced hypertension and consequences of neonatal androgenization.
  Plut C, Ribiere C, Giudicelli Y, Dausse JP
  J Pharmacol Exp Ther. 2002
  PubMed ID: 12130711
   
  
• Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons.
  Honma Y, Araki T, Gianino S, Bruce A, Heuckeroth R, Johnson E, Milbrandt J
  Neuron. 2002
  PubMed ID: 12160745
   
  
• Dynamics of tyrosine hydroxylase promoter activity during midbrain dopaminergic neuron development.
  Matsushita N, Okada H, Yasoshima Y, Takahashi K, Kiuchi K, Kobayashi K
  J Neurochem. 2002
  PubMed ID: 12124430
   
  
• Homeobox gene hoxa3 is essential for the formation of the carotid body in the mouse embryos.
  Kameda Y, Nishimaki T, Takeichi M, Chisaka O
  Dev Biol. 2002
  PubMed ID: 12074562
   
  
• Developmental timing of hair follicle and dorsal skin innervation in mice.
  Peters EM, Botchkarev VA, Müller-Röver S, Moll I, Rice FL, Paus R
  J Comp Neurol. 2002
  PubMed ID: 12012374
   
  
• Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology.
  Fukami S, Watanabe K, Iwata N, Haraoka J, Lu B, Gerard NP, Gerard C, Fraser P, Westaway D, St George-Hyslop P, Saido TC
  Neurosci Res. 2002
  PubMed ID: 12074840
   
  
• Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB.
  Lonze BE, Riccio A, Cohen S, Ginty DD
  Neuron. 2002
  PubMed ID: 11988169
   
  
• Peroxynitrite-induced nitration of tyrosine hydroxylase: identification of tyrosines 423, 428, and 432 as sites of modification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry and tyrosine-scanning mutagenesis.
  Kuhn DM, Sadidi M, Liu X, Kreipke C, Geddes T, Borges C, Watson JT
  J Biol Chem. 2002
  PubMed ID: 11834745
   
  
• A role for alpha-synuclein in the regulation of dopamine biosynthesis.
  Perez RG, Waymire JC, Lin E, Liu JJ, Guo F, Zigmond MJ
  J Neurosci. 2002
  PubMed ID: 11943812
   
  
• Role of tryptophan hydroxylase phe313 in determining substrate specificity.
  Daubner SC, Moran GR, Fitzpatrick PF
  Biochem Biophys Res Commun. 2002
  PubMed ID: 11922614
   
  
• Testosterone increased blood pressure and decreased renal tyrosine hydroxylase activity in SHR/y and Wistar-Kyoto rats.
  Sharma U, Dunphy G, Ely D
  Clin Exp Hypertens. 2002
  PubMed ID: 11883789
   
  
• Estradiol stimulates gene expression of norepinephrine biosynthetic enzymes in rat locus coeruleus.
  Serova L, Rivkin M, Nakashima A, Sabban EL
  Neuroendocrinology. 2002
  PubMed ID: 11914591
   
  
• Transcriptional and post-transcriptional regulation of tyrosine hydroxylase messenger RNA in PC12 cells during persistent stimulation by VIP and PACAP38: differential regulation by protein kinase A and protein kinase C-dependent pathways.
  Corbitt J, Hagerty T, Fernandez E, Morgan WW, Strong R
  Neuropeptides. 2002
  PubMed ID: 12147212
   
  
• Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections.
  Marín O, Baker J, Puelles L, Rubenstein JL
  Development. 2002
  PubMed ID: 11830575
   
  
• Requirement of neuropilin 1-mediated Sema3A signals in patterning of the sympathetic nervous system.
  Kawasaki T, Bekku Y, Suto F, Kitsukawa T, Taniguchi M, Nagatsu I, Nagatsu T, Itoh K, Yagi T, Fujisawa H
  Development. 2002
  PubMed ID: 11830568
   
  
• Essential role for the lymphostromal plasma membrane Ly-6 superfamily molecule thymic shared antigen 1 in development of the embryonic adrenal gland.
  Zammit DJ, Berzins SP, Gill JW, Randle-Barrett ES, Barnett L, Koentgen F, Lambert GW, Harvey RP, Boyd RL, Classon BJ
  Mol Cell Biol. 2002
  PubMed ID: 11784869
   
  
• Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.
  Bagri A, Marín O, Plump AS, Mak J, Pleasure SJ, Rubenstein JL, Tessier-Lavigne M
  Neuron. 2002
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• Purification and characterization of the active form of tyrosine hydroxylase from mesangial cells in culture.
  Arita DY, Di Marco GS, Schor N, Casarini DE
  J Cell Biochem. 2002
  PubMed ID: 12210722
   
  
• Association between tyrosine hydroxylase polymorphisms and left ventricular structure in young normotensive men.
  Linhart A, Jindra A, Golán L, Jáchymová M, Sedlácek K, Peleska J, Umnerová V, Bultas J, Horký K, Aschermann M
  Br J Biomed Sci. 2002
  PubMed ID: 12113410
   
  
• Overexpression of c-Fos is sufficient to stimulate tyrosine hydroxylase (TH) gene transcription in rat pheochromocytoma PC18 cells.
  Sun B, Tank AW
  J Neurochem. 2002
  PubMed ID: 11902120
   
  
• Melatonin induces tyrosine hydroxylase mRNA expression in the ventral mesencephalon but not in the hypothalamus.
  Venero JL, Absi el-H, Cano J, Machado A
  J Pineal Res. 2002
  PubMed ID: 11841594
   
  
• Apoptosis in the preimplantation mouse embryo: effect of strain difference and in vitro culture.
  Kamjoo M, Brison DR, Kimber SJ
  Mol Reprod Dev. 2002
  PubMed ID: 11774377
   
  
• Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis.
  Washbourne P, Thompson PM, Carta M, Costa ET, Mathews JR, Lopez-Benditó G, Molnár Z, Becher MW, Valenzuela CF, Partridge LD, Wilson MC
  Nat Neurosci. 2002
  PubMed ID: 11753414
   
  
• Gene expression of catecholamine synthesizing enzymes in A5 cell group and modulation of tyrosine hydroxylase mRNA by immobilization stress.
  Micutkova L, Kiss A, Filipenko M, Rychkova N, Krizanova O, Palkovits M, Kvetnansky R
  Endocr Regul. 2001
  PubMed ID: 11858766
   
  
• Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem.
  Wallén A A, Castro DS, Zetterström RH, Karlén M, Olson L, Ericson J, Perlmann T
  Mol Cell Neurosci. 2001
  PubMed ID: 11749040
   
  
• Genetic evidence for noradrenergic control of long-term memory consolidation.
  Kobayashi K, Kobayashi T
  Brain Dev. 2001
  PubMed ID: 11738836
   
  
• A role for Gsh1 in the developing striatum and olfactory bulb of Gsh2 mutant mice.
  Toresson H, Campbell K
  Development. 2001
  PubMed ID: 11731457
   
  
• Phosphorylation of Ser(19) alters the conformation of tyrosine hydroxylase to increase the rate of phosphorylation of Ser(40).
  Bevilaqua LR, Graham ME, Dunkley PR, von Nagy-Felsobuki EI, Dickson PW
  J Biol Chem. 2001
  PubMed ID: 11502746
   
  
• Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS.
  Sakakibara S, Nakamura Y, Satoh H, Okano H
  J Neurosci. 2001
  PubMed ID: 11588182
   
  
• RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons.
  Enomoto H, Crawford PA, Gorodinsky A, Heuckeroth RO, Johnson EM, Milbrandt J
  Development. 2001
  PubMed ID: 11641220
   
  
• Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3.
  Qian Y, Fritzsch B, Shirasawa S, Chen CL, Choi Y, Ma Q
  Genes Dev. 2001
  PubMed ID: 11581159
   
  
• Induction of stereotypy in dopamine-deficient mice requires striatal D1 receptor activation.
  Chartoff EH, Marck BT, Matsumoto AM, Dorsa DM, Palmiter RD
  Proc Natl Acad Sci U S A. 2001
  PubMed ID: 11517332
   
  
• Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain.
  Hirata H, Tomita K, Bessho Y, Kageyama R
  EMBO J. 2001
  PubMed ID: 11500373
   
  
• Math5 is required for retinal ganglion cell and optic nerve formation.
  Brown NL, Patel S, Brzezinski J, Glaser T
  Development. 2001
  PubMed ID: 11493566
   
  
• Mice lacking the Nkx6.2 (Gtx) homeodomain transcription factor develop and reproduce normally.
  Cai J, Qi Y, Wu R, Modderman G, Fu H, Liu R, Qiu M
  Mol Cell Biol. 2001
  PubMed ID: 11390667
   
  
• Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice.
  Szczypka MS, Kwok K, Brot MD, Marck BT, Matsumoto AM, Donahue BA, Palmiter RD
  Neuron. 2001
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• Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent association.
  Kleppe R, Toska K, Haavik J
  J Neurochem. 2001
  PubMed ID: 11359875
   
  
• Exon 3 of tyrosine hydroxylase gene: lack of association with Japanese schizophrenic patients.
  Ota M, Nakashima A, Ikemoto K, Nojima S, Tanaka M, Okuda M, Koga H, Mori K, Kaneko YS, Fujiwara K, Yamamoto H, Nagatsu T, Ota A
  Mol Psychiatry. 2001
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• Fate of midbrain dopaminergic neurons controlled by the engrailed genes.
  Simon HH, Saueressig H, Wurst W, Goulding MD, O'Leary DD
  J Neurosci. 2001
  PubMed ID: 11312297
   
  
• Functional annotation of a full-length mouse cDNA collection.
  Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
  Nature. 2001
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• Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor are required simultaneously for survival of dopaminergic primary sensory neurons in vivo.
  Erickson JT, Brosenitsch TA, Katz DM
  J Neurosci. 2001
  PubMed ID: 11160437
   
  
• Deletion of tyrosine hydroxylase gene reveals functional interdependence of adrenocortical and chromaffin cell system in vivo.
  Bornstein SR, Tian H, Haidan A, Böttner A, Hiroi N, Eisenhofer G, McCann SM, Chrousos GP, Roffler-Tarlov S
  Proc Natl Acad Sci U S A. 2000
  PubMed ID: 11121073
   
  
• Evidence for intrinsic development of olfactory structures in Pax-6 mutant mice.
  Jiménez D, García C, de Castro F, Chédotal A, Sotelo C, de Carlos JA, Valverde F, López-Mascaraque L
  J Comp Neurol. 2000
  PubMed ID: 11074448
   
  
• The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons.
  Sakai R, Henderson JT, O'Bryan JP, Elia AJ, Saxton TM, Pawson T
  Neuron. 2000
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• RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
  Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
  Genome Res. 2000
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• Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain.
  Onyango P, Miller W, Lehoczky J, Leung CT, Birren B, Wheelan S, Dewar K, Feinberg AP
  Genome Res. 2000
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• Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo.
  Rossi J, Tomac A, Saarma M, Airaksinen MS
  Eur J Neurosci. 2000
  PubMed ID: 11069590
   
  
• Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting.
  Engemann S, Strödicke M, Paulsen M, Franck O, Reinhardt R, Lane N, Reik W, Walter J
  Hum Mol Genet. 2000
  PubMed ID: 11063728
   
  
• Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin.
  Enomoto H, Heuckeroth RO, Golden JP, Johnson EM, Milbrandt J
  Development. 2000
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• p75 is important for axon growth and schwann cell migration during development.
  Bentley CA, Lee KF
  J Neurosci. 2000
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• Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
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  Genome Res. 2000
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• Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS.
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• Catecholamines are required for the acquisition of secretory responsiveness by sweat glands.
  Tian H, Habecker B, Guidry G, Gurtan A, Rios M, Roffler-Tarlov S, Landis SC
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• Dopamine control of striatal gene expression during development: relevance to knockout mice for the dopamine transporter.
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  Eur J Neurosci. 2000
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• GDNF family receptors in the embryonic and postnatal rat heart and reduced cholinergic innervation in mice hearts lacking ret or GFRalpha2.
  Hiltunen JO, Laurikainen A, Airaksinen MS, Saarma M
  Dev Dyn. 2000
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• Defect of tyrosine hydroxylase-immunoreactive neurons in the brains of mice lacking the transcription factor Pax6.
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• Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
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  Proc Natl Acad Sci U S A. 2000
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• Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family.
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• Characterization of single-nucleotide polymorphisms in coding regions of human genes.
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• Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome.
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• Impaired extrapyramidal function caused by the targeted disruption of retinoid X receptor RXRgamma1 isoform.
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• A human tyrosine hydroxylase isoform associated with progressive supranuclear palsy shows altered enzymatic activity.
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• The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system.
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• Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons.
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• Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons.
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• Isolation and characterization of ovine tyrosine hydroxylase mRNA.
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• Comparative mapping of novel simple sequence repeat markers in a hypertension-related region on rat chromosome 1.
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• Effect of the weaver mutation on the expression of dopamine membrane transporter, tyrosine hydroxylase and vesicular monoamine transporter in dopaminergic neurons of the substantia nigra and the ventral tegmental area.
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• Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1.
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• TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo.
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• POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells.
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• Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and Mash-1-dependence.
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• Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids.
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• Targeted disruption of the tyrosine hydroxylase locus results in severe catecholamine depletion and perinatal lethality in mice.
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  Hum Mol Genet. 1995
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• Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.
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  Nature. 1995
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• Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development.
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  Nature. 1995
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• A point mutation in the tyrosine hydroxylase gene associated with Segawa's syndrome.
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• Mapping of the genes for four members of the transmembrane 4 superfamily: mouse Cd9, Cd63, Cd81, and Cd82.
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• Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40.
  Haycock JW
  J Biol Chem. 1990
  PubMed ID: 1973163
   
  
• The NXSM recombinant inbred strains of mice: genetic profile for 58 loci including the Mtv proviral loci.
  Eicher EM, Lee BK
  Genetics. 1990
  PubMed ID: 2165966
   
  
• Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease.
  Wolff JA, Fisher LJ, Xu L, Jinnah HA, Langlais PJ, Iuvone PM, O'Malley KL, Rosenberg MB, Shimohama S, Friedmann T
  Proc Natl Acad Sci U S A. 1989
  PubMed ID: 2573072
   
  
• Characterization of rat and human tyrosine hydroxylase genes: functional expression of both promoters in neuronal and non-neuronal cell types.
  Coker GT, Vinnedge L, O'Malley KL
  Biochem Biophys Res Commun. 1988
  PubMed ID: 2905129
   
  
• Human tyrosinase gene, mapped to chromosome 11 (q14----q21), defines second region of homology with mouse chromosome 7.
  Barton DE, Kwon BS, Francke U
  Genomics. 1988
  PubMed ID: 3146546
   
  
• Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types.
  Kobayashi K, Kaneda N, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T
  J Biochem. 1988
  PubMed ID: 2902075
   
  
• Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector.
  Ginns EI, Rehavi M, Martin BM, Weller M, O'Malley KL, LaMarca ME, McAllister CG, Paul SM
  J Biol Chem. 1988
  PubMed ID: 2896667
   
  
• Analysis of the 5' region of the human tyrosine hydroxylase gene: combinatorial patterns of exon splicing generate multiple regulated tyrosine hydroxylase isoforms.
  Le Bourdellès B, Boularand S, Boni C, Horellou P, Dumas S, Grima B, Mallet J
  J Neurochem. 1988
  PubMed ID: 2892893
   
  
• Isolation and characterization of the human tyrosine hydroxylase gene: identification of 5' alternative splice sites responsible for multiple mRNAs.
  O'Malley KL, Anhalt MJ, Martin BM, Kelsoe JR, Winfield SL, Ginns EI
  Biochemistry. 1987
  PubMed ID: 2892528
   
  
• Isolation of a full-length cDNA clone encoding human tyrosine hydroxylase type 3.
  Kobayashi K, Kaneda N, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T
  Nucleic Acids Res. 1987
  PubMed ID: 2888085
   
  
• Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene.
  Kaneda N, Kobayashi K, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T
  Biochem Biophys Res Commun. 1987
  PubMed ID: 2887169
   
  
• Organization and evolution of the rat tyrosine hydroxylase gene.
  Brown ER, Coker GT, O'Malley KL
  Biochemistry. 1987
  PubMed ID: 2889468
   
  
• Murine tyrosine hydroxylase maps to the distal end of chromosome 7 within a region conserved in mouse and man.
  Brilliant MH, Niemann MM, Eicher EM
  J Neurogenet. 1987
  PubMed ID: 2889817
   
  
• Genetic determination of mesencephalic tyrosine hydroxylase activity in the mouse.
  Vadász C, Sziráki I, Murthy LR, Vadász I, Badalamenti AF, Kóbor G, Lajtha A
  J Neurogenet. 1987
  PubMed ID: 2889816
   
  
• Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP.
  Lewis EJ, Harrington CA, Chikaraishi DM
  Proc Natl Acad Sci U S A. 1987
  PubMed ID: 2884660
   
  
• A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics.
  Grima B, Lamouroux A, Boni C, Julien JF, Javoy-Agid F, Mallet J
  Nature. 1987
  PubMed ID: 2882428
   
  
• Identification and cell type specificity of the tyrosine hydroxylase gene promoter.
  Harrington CA, Lewis EJ, Krzemien D, Chikaraishi DM
  Nucleic Acids Res. 1987
  PubMed ID: 2882469
   
  
• A single RNA species injected in Xenopus oocyte directs the synthesis of active tyrosine hydroxylase.
  Horellou P, Guibert B, Leviel V, Mallet J
  FEBS Lett. 1986
  PubMed ID: 2427363
   
  
• Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase.
  Campbell DG, Hardie DG, Vulliet PR
  J Biol Chem. 1986
  PubMed ID: 2874140
   
  
• Activities of cerebral dihydropteridine reductase and tyrosine hydroxylase in chronic uremia in rats.
  Mullen BJ, Wang M
  J Nutr. 1986
  PubMed ID: 2875142
   
  
• Localization of the human tyrosine hydroxylase gene to 11p15: gene duplication and evolution of metabolic pathways.
  Craig SP, Buckle VJ, Lamouroux A, Mallet J, Craig I
  Cytogenet Cell Genet. 1986
  PubMed ID: 2872999
   
  
• Complete coding sequence of rat tyrosine hydroxylase mRNA.
  Grima B, Lamouroux A, Blanot F, Biguet NF, Mallet J
  Proc Natl Acad Sci U S A. 1985
  PubMed ID: 2857492
   
  
• Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase.
  Vulliet PR, Woodgett JR, Cohen P
  J Biol Chem. 1984
  PubMed ID: 6150037
   
  
• Tyrosine hydroxylase regulation in the central nervous system.
  Masserano JM, Weiner N
  Mol Cell Biochem. 1983
  PubMed ID: 6137760
   
  
• Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation.
  Joh TH, Park DH, Reis DJ
  Proc Natl Acad Sci U S A. 1978
  PubMed ID: 33381
   
  
• The activity of some neurotransmitter-synthetizing enzymes in experimental cobalt epilepsy.
  Altamura AC, Bonati M, Brunello N, Giordano PL, Algeri S
  Neurosci Lett. 1978
  PubMed ID: 19605093
   
  
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  PubMed ID: 20301610