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TDGF1

Gene Description:   teratocarcinoma-derived growth factor 1 Synonyms:   CRIPTO, CRGF, TDGF1, CR1, CR, cripto, Tdgf1 Orthologs:   Human TDGF1 (protein-coding), Mouse Tdgf1 (protein-coding), Rat Tdgf1 (protein-coding)   Sources Sources Human-Mouse: MGD, RGD, Inparanoid, OrthoMCL Human-Rat: MGD, RGD, Inparanoid, OrthoMCL Mouse-Rat: MGD, RGD, Inparanoid, OrthoMCL Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1 Rat: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
3p21.31	Human	chr3:45980673..46654132	0.67	77	rs333 rs11711054

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 3p21.31 Orthologous Region	Rat	chr8:115324105..115463724	0.14	7
Human 3p21.31 Orthologous Region	Mouse	chr9:110823597..110967895	0.14	5

(Human) GRCh37 - chr3:46616045..46623953 (7.91 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr9:110842112..110848662 (6.55 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr8:115341587..115346871 (5.28 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas       no data         no data no data no data no data no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Interactions Table for TDGF1: The TDGF1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs TDGF1   COPS6   HPRD, MINT, IntAct, BioGRID  empirical  16169070  TDGF1   ACVR1C   HPRD, Reactome  empirical  11485994  TDGF1   GDF9   HPRD, MINT, IntAct, BioGRID  empirical  16169070  TDGF1   GPC1   MINT  empirical  19013461  TDGF1   ANG   HPRD, IntAct  empirical  16169070  TDGF1   RIF1   IntAct, BioGRID  empirical  16169070  TDGF1   LRIF1   HPRD, MINT  empirical  16169070  TDGF1   BAG6   HPRD, MINT, IntAct, BioGRID  empirical  16169070  TDGF1   ACVR1B   HPRD, BioGRID, Reactome  empirical  11909953  TDGF1   ACVR2A   Reactome  predicted    TDGF1   ACVR2B   Reactome  predicted

View all

KEGG Network: None available   None available.

Biocarta: None available   None available.

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: 1   Glypican 1 network

Gene Ontology: 21   Activation of MAPK activity GO:0000187 Morphogenesis of a branching structure GO:0001763 Receptor binding GO:0005102 Protein binding GO:0005515 Plasma membrane GO:0005886 Epidermal growth factor receptor signaling pathway GO:0007173 Heart development GO:0007507 Growth factor activity GO:0008083 Positive regulation of cell proliferation GO:0008284 Anterior/posterior axis specification, embryo GO:0008595 Embryo development GO:0009790 Regulation of signal transduction GO:0009966 Cell surface GO:0009986 Peptidyl-serine phosphorylation GO:0018105 Extrinsic to plasma membrane GO:0019897 Cell differentiation GO:0030154 Positive regulation of cell migration GO:0030335 Mammary gland development GO:0030879 Anchored to membrane GO:0031225 Negative regulation of apoptosis GO:0043066 Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731

	KEGG Network: None available
	Biocarta: None available
	Reactome: None available
	NCI-Nature Pathway Interaction Database: 1 Glypican 1 network
	Gene Ontology: 21 Activation of MAPK activity GO:0000187 Morphogenesis of a branching structure GO:0001763 Receptor binding GO:0005102 Protein binding GO:0005515 Plasma membrane GO:0005886 Epidermal growth factor receptor signaling pathway GO:0007173 Heart development GO:0007507 Growth factor activity GO:0008083 Positive regulation of cell proliferation GO:0008284 Anterior/posterior axis specification, embryo GO:0008595 Embryo development GO:0009790 Regulation of signal transduction GO:0009966 Cell surface GO:0009986 Peptidyl-serine phosphorylation GO:0018105 Extrinsic to plasma membrane GO:0019897 Cell differentiation GO:0030154 Positive regulation of cell migration GO:0030335 Mammary gland development GO:0030879 Anchored to membrane GO:0031225 Negative regulation of apoptosis GO:0043066 Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731

Type 1 Diabetes Publications: 1

• Inhibition of activin signaling induces pancreatic epithelial cell expansion and diminishes terminal differentiation of pancreatic beta-cells.
  Zhang YQ, Cleary MM, Si Y, Liu G, Eto Y, Kritzik M, Dabernat S, Kayali AG, Sarvetnick N
  Diabetes. 2004
  PubMed ID: 15277382
   
  

Publications: 161

• Altered expression of activin, cripto, and follistatin in the endometrium of women with endometrioma.
  Rocha AL, Carrarelli P, Novembri R, Sabbioni L, Luisi S, Reis FM, Petraglia F
  Fertil Steril. 2011
  PubMed ID: 21496809
   
  
• Correct patterning of the primitive streak requires the anterior visceral endoderm.
  Stuckey DW, Di Gregorio A, Clements M, Rodriguez TA
  PLoS One. 2011
  PubMed ID: 21445260
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Intercellular transfer regulation of the paracrine activity of GPI-anchored Cripto-1 as a Nodal co-receptor.
  Watanabe K, Salomon DS
  Biochem Biophys Res Commun. 2010
  PubMed ID: 21055389
   
  
• Oct1 regulates trophoblast development during early mouse embryogenesis.
  Sebastiano V, Dalvai M, Gentile L, Schubart K, Sutter J, Wu GM, Tapia N, Esch D, Ju JY, Hübner K, Bravo MJ, Schöler HR, Cavaleri F, Matthias P
  Development. 2010
  PubMed ID: 20876643
   
  
• Structural investigations on the Nodal-Cripto binding: a theoretical and experimental approach.
  Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
  Biopolymers. 2010
  PubMed ID: 20629020
   
  
• An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo.
  Spruce T, Pernaute B, Di-Gregorio A, Cobb BS, Merkenschlager M, Manzanares M, Rodriguez TA
  Dev Cell. 2010
  PubMed ID: 20708584
   
  
• Cripto-1 is a cell surface marker for a tumorigenic, undifferentiated subpopulation in human embryonal carcinoma cells.
  Watanabe K, Meyer MJ, Strizzi L, Lee JM, Gonzales M, Bianco C, Nagaoka T, Farid SS, Margaryan N, Hendrix MJ, Vonderhaar BK, Salomon DS
  Stem Cells. 2010
  PubMed ID: 20549704
   
  
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
  Mol Med. 2010
  PubMed ID: 20379614
   
  
• Genetic evidence that SOST inhibits WNT signaling in the limb.
  Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG
  Dev Biol. 2010
  PubMed ID: 20359476
   
  
• Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro.
  Williams TA, Monticone S, Morello F, Liew CC, Mengozzi G, Pilon C, Asioli S, Sapino A, Veglio F, Mulatero P
  Hypertension. 2010
  PubMed ID: 20385969
   
  
• Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis.
  Chu J, Shen MM
  Dev Biol. 2010
  PubMed ID: 20346354
   
  
• Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo.
  Miura S, Singh AP, Mishina Y
  Dev Biol. 2010
  PubMed ID: 20211162
   
  
• TDGF1 is a novel predictive marker for metachronous metastasis of colorectal cancer.
  Miyoshi N, Ishii H, Mimori K, Sekimoto M, Doki Y, Mori M
  Int J Oncol. 2010
  PubMed ID: 20126975
   
  
• Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions.
  Zhang JG, Zhao J, Xin Y
  World J Gastroenterol. 2010
  PubMed ID: 20128024
   
  
• The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.
  Krentz AD, Murphy MW, Kim S, Cook MS, Capel B, Zhu R, Matin A, Sarver AL, Parker KL, Griswold MD, Looijenga LH, Bardwell VJ, Zarkower D
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 20007774
   
  
• Cripto-1 is required for hypoxia to induce cardiac differentiation of mouse embryonic stem cells.
  Bianco C, Cotten C, Lonardo E, Strizzi L, Baraty C, Mancino M, Gonzales M, Watanabe K, Nagaoka T, Berry C, Arai AE, Minchiotti G, Salomon DS
  Am J Pathol. 2009
  PubMed ID: 19834060
   
  
• Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate.
  Natale DR, Hemberger M, Hughes M, Cross JC
  Dev Biol. 2009
  PubMed ID: 19716815
   
  
• Teratocarcinoma-derived growth factor 1 (TDGF1) sequence variants in patients with congenital heart defect.
  Wang B, Yan J, Peng Z, Wang J, Liu S, Xie X, Ma X
  Int J Cardiol. 2009
  PubMed ID: 19853938
   
  
• Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women.
  Li GH, Kung AW, Huang QY
  Osteoporos Int. 2009
  PubMed ID: 19727905
   
  
• Activin A, activin receptor type II, nodal, and cripto mRNA are expressed by eutopic and ectopic endometrium in women with ovarian endometriosis.
  Torres PB, Florio P, Galleri L, Reis FM, Borges LE, Petraglia F
  Reprod Sci. 2009
  PubMed ID: 19386982
   
  
• G protein-coupled receptor APJ and its ligand apelin act downstream of Cripto to specify embryonic stem cells toward the cardiac lineage through extracellular signal-regulated kinase/p70S6 kinase signaling pathway.
  D'Aniello C, Lonardo E, Iaconis S, Guardiola O, Liguoro AM, Liguori GL, Autiero M, Carmeliet P, Minchiotti G
  Circ Res. 2009
  PubMed ID: 19574549
   
  
• Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning.
  Uehara M, Yashiro K, Takaoka K, Yamamoto M, Hamada H
  Genes Dev. 2009
  PubMed ID: 19605690
   
  
• Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways.
  Kelber JA, Panopoulos AD, Shani G, Booker EC, Belmonte JC, Vale WW, Gray PC
  Oncogene. 2009
  PubMed ID: 19421146
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor.
  Calvanese L, Saporito A, Oliva R, D' Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L
  J Pept Sci. 2009
  PubMed ID: 19035567
   
  
• Qualitative and quantitative proteomic profiling of cripto(-/-) embryonic stem cells by means of accurate mass LC-MS analysis.
  Chambery A, Vissers JP, Langridge JI, Lonardo E, Minchiotti G, Ruvo M, Parente A
  J Proteome Res. 2009
  PubMed ID: 19152270
   
  
• Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo.
  Yamamoto M, Beppu H, Takaoka K, Meno C, Li E, Miyazono K, Hamada H
  J Cell Biol. 2009
  PubMed ID: 19153222
   
  
• Expression of nodal signalling components in cycling human endometrium and in endometrial cancer.
  Papageorgiou I, Nicholls PK, Wang F, Lackmann M, Makanji Y, Salamonsen LA, Robertson DM, Harrison CA
  Reprod Biol Endocrinol. 2009
  PubMed ID: 19874624
   
  
• Cripto-1 overexpression is involved in the tumorigenesis of nasopharyngeal carcinoma.
  Wu Z, Li G, Wu L, Weng D, Li X, Yao K
  BMC Cancer. 2009
  PubMed ID: 19732464
   
  
• Characterization of the functional properties of the neuroectoderm in mouse Cripto(-/-) embryos showing severe gastrulation defects.
  Liguori GL, Echevarria D, Bonilla S, D'Andrea D, Liguoro A, Persico MG, Martinez S
  Int J Dev Biol. 2009
  PubMed ID: 19247965
   
  
• Cripto-1 overexpression is involved in the tumorigenesis of gastric-type and pancreatobiliary-type intraductal papillary mucinous neoplasms of the pancreas.
  Hong SP, Lee EK, Park JY, Jeon TJ, Bang S, Park S, Chung JB, Lee WJ, Kim H, Song SY
  Oncol Rep. 2009
  PubMed ID: 19082438
   
  
• Activation of a Nodal-independent signaling pathway by Cripto-1 mutants with impaired activation of a Nodal-dependent signaling pathway.
  Bianco C, Mysliwiec M, Watanabe K, Mancino M, Nagaoka T, Gonzales M, Salomon DS
  FEBS Lett. 2008
  PubMed ID: 19013461
   
  
• CRIPTO3, a presumed pseudogene, is expressed in cancer.
  Sun C, Orozco O, Olson DL, Choi E, Garber E, Tizard R, Szak S, Sanicola M, Carulli JP
  Biochem Biophys Res Commun. 2008
  PubMed ID: 18835250
   
  
• Characterization of the glycosylphosphatidylinositol-anchor signal sequence of human Cryptic with a hydrophilic extension.
  Watanabe K, Nagaoka T, Strizzi L, Mancino M, Gonzales M, Bianco C, Salomon DS
  Biochim Biophys Acta. 2008
  PubMed ID: 18930707
   
  
• Left-asymmetric expression of Galanin in the linear heart tube of the mouse embryo is independent of the nodal co-receptor gene cryptic.
  Schweickert A, Deissler K, Britsch S, Albrecht M, Ehmann H, Mauch V, Gaio U, Blum M
  Dev Dyn. 2008
  PubMed ID: 18773496
   
  
• Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner.
  Ishimura A, Chida S, Osada S
  Dev Dyn. 2008
  PubMed ID: 18697220
   
  
• Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation.
  Blanchet MH, Le Good JA, Mesnard D, Oorschot V, Baflast S, Minchiotti G, Klumperman J, Constam DB
  EMBO J. 2008
  PubMed ID: 18772886
   
  
• Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.
  Landry J, Sharov AA, Piao Y, Sharova LV, Xiao H, Southon E, Matta J, Tessarollo L, Zhang YE, Ko MS, Kuehn MR, Yamaguchi TP, Wu C
  PLoS Genet. 2008
  PubMed ID: 18974875
   
  
• Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
  Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
  Genome Res. 2008
  PubMed ID: 18799693
   
  
• Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo.
  Uez N, Lickert H, Kohlhase J, de Angelis MH, Kühn R, Wurst W, Floss T
  Genesis. 2008
  PubMed ID: 18781635
   
  
• Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland.
  Strizzi L, Mancino M, Bianco C, Raafat A, Gonzales M, Booth BW, Watanabe K, Nagaoka T, Mack DL, Howard B, Callahan R, Smith GH, Salomon DS
  J Cell Physiol. 2008
  PubMed ID: 18425773
   
  
• Positive association of up-regulated Cripto-1 and down-regulated E-cadherin with tumour progression and poor prognosis in gastric cancer.
  Zhong XY, Zhang LH, Jia SQ, Shi T, Niu ZJ, Du H, Zhang GG, Hu Y, Lu AP, Li JY, Ji JF
  Histopathology. 2008
  PubMed ID: 18312357
   
  
• Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells.
  Mancino M, Strizzi L, Wechselberger C, Watanabe K, Gonzales M, Hamada S, Normanno N, Salomon DS, Bianco C
  J Cell Physiol. 2008
  PubMed ID: 17941089
   
  
• Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo.
  Liguori GL, Borges AC, D'Andrea D, Liguoro A, Gonçalves L, Salgueiro AM, Persico MG, Belo JA
  Dev Biol. 2008
  PubMed ID: 18241853
   
  
• Cripto-1 alters keratinocyte differentiation via blockade of transforming growth factor-beta1 signaling: role in skin carcinogenesis.
  Shukla A, Ho Y, Liu X, Ryscavage A, Glick AB
  Mol Cancer Res. 2008
  PubMed ID: 18337457
   
  
• Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal.
  Kelber JA, Shani G, Booker EC, Vale WW, Gray PC
  J Biol Chem. 2008
  PubMed ID: 18089557
   
  
• Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction.
  D'Andrea D, Liguori GL, Le Good JA, Lonardo E, Andersson O, Constam DB, Persico MG, Minchiotti G
  J Cell Biol. 2008
  PubMed ID: 18268105
   
  
• Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse.
  Arnold SJ, Hofmann UK, Bikoff EK, Robertson EJ
  Development. 2008
  PubMed ID: 18171685
   
  
• Cripto localizes Nodal at the limiting membrane of early endosomes.
  Blanchet MH, Le Good JA, Oorschot V, Baflast S, Minchiotti G, Klumperman J, Constam DB
  Sci Signal. 2008
  PubMed ID: 19001664
   
  
• GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth.
  Shani G, Fischer WH, Justice NJ, Kelber JA, Vale W, Gray PC
  Mol Cell Biol. 2008
  PubMed ID: 17991893
   
  
• Requirement of glycosylphosphatidylinositol anchor of Cripto-1 for trans activity as a Nodal co-receptor.
  Watanabe K, Hamada S, Bianco C, Mancino M, Nagaoka T, Gonzales M, Bailly V, Strizzi L, Salomon DS
  J Biol Chem. 2007
  PubMed ID: 17925387
   
  
• Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis.
  Barrow JR, Howell WD, Rule M, Hayashi S, Thomas KR, Capecchi MR, McMahon AP
  Dev Biol. 2007
  PubMed ID: 18028899
   
  
• Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development.
  Andersson O, Bertolino P, Ibáñez CF
  Dev Biol. 2007
  PubMed ID: 17936261
   
  
• Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo.
  Oki S, Hashimoto R, Okui Y, Shen MM, Mekada E, Otani H, Saijoh Y, Hamada H
  Development. 2007
  PubMed ID: 17913787
   
  
• Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration.
  Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS
  J Biol Chem. 2007
  PubMed ID: 17720976
   
  
• Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome.
  Bondareva AA, Capecchi MR, Iverson SV, Li Y, Lopez NI, Lucas O, Merrill GF, Prigge JR, Siders AM, Wakamiya M, Wallin SL, Schmidt EE
  Free Radic Biol Med. 2007
  PubMed ID: 17697936
   
  
• EUCOMM--the European conditional mouse mutagenesis program.
  Friedel RH, Seisenberger C, Kaloff C, Wurst W
  Brief Funct Genomic Proteomic. 2007
  PubMed ID: 17967808
   
  
• BMP signalling inhibits premature neural differentiation in the mouse embryo.
  Di-Gregorio A, Sancho M, Stuckey DW, Crompton LA, Godwin J, Mishina Y, Rodriguez TA
  Development. 2007
  PubMed ID: 17699604
   
  
• Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development.
  Izzi L, Silvestri C, von Both I, Labbé E, Zakin L, Wrana JL, Attisano L
  EMBO J. 2007
  PubMed ID: 17568773
   
  
• Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.
  Kimura-Yoshida C, Tian E, Nakano H, Amazaki S, Shimokawa K, Rossant J, Aizawa S, Matsuo I
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17389379
   
  
• beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1.
  Hamada S, Watanabe K, Hirota M, Bianco C, Strizzi L, Mancino M, Gonzales M, Salomon DS
  Biochem Biophys Res Commun. 2007
  PubMed ID: 17291450
   
  
• Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells.
  Liu Y, Asakura M, Inoue H, Nakamura T, Sano M, Niu Z, Chen M, Schwartz RJ, Schneider MD
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17360443
   
  
• hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
  Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G, Martin P, Rogers J, Lawlor S, McLaren S, Dricot A, Borick H, Cusick ME, Vandenhaute J, Dunham I, Hill DE, Vidal M
  Genomics. 2007
  PubMed ID: 17207965
   
  
• Cripto binds transforming growth factor beta (TGF-beta) and inhibits TGF-beta signaling.
  Gray PC, Shani G, Aung K, Kelber J, Vale W
  Mol Cell Biol. 2006
  PubMed ID: 17030617
   
  
• Germ cell nuclear factor is a repressor of CRIPTO-1 and CRIPTO-3.
  Hentschke M, Kurth I, Borgmeyer U, Hübner CA
  J Biol Chem. 2006
  PubMed ID: 16954206
   
  
• Identification of cripto-1 as a novel serologic marker for breast and colon cancer.
  Bianco C, Strizzi L, Mancino M, Rehman A, Hamada S, Watanabe K, De Luca A, Jones B, Balogh G, Russo J, Mailo D, Palaia R, D'Aiuto G, Botti G, Perrone F, Salomon DS, Normanno N
  Clin Cancer Res. 2006
  PubMed ID: 16951234
   
  
• The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4.
  Ben-Haim N, Lu C, Guzman-Ayala M, Pescatore L, Mesnard D, Bischofberger M, Naef F, Robertson EJ, Constam DB
  Dev Cell. 2006
  PubMed ID: 16950123
   
  
• Disruption of early proximodistal patterning and AVE formation in Apc mutants.
  Chazaud C, Rossant J
  Development. 2006
  PubMed ID: 16887818
   
  
• Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching.
  Rakeman AS, Anderson KV
  Development. 2006
  PubMed ID: 16831833
   
  
• The DNA sequence, annotation and analysis of human chromosome 3.
  Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA
  Nature. 2006
  PubMed ID: 16641997
   
  
• The mouse embryo autonomously acquires anterior-posterior polarity at implantation.
  Takaoka K, Yamamoto M, Shiratori H, Meno C, Rossant J, Saijoh Y, Hamada H
  Dev Cell. 2006
  PubMed ID: 16580991
   
  
• Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development.
  Georgiades P, Rossant J
  Development. 2006
  PubMed ID: 16481355
   
  
• The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo.
  Chen C, Ware SM, Sato A, Houston-Hawkins DE, Habas R, Matzuk MM, Shen MM, Brown CW
  Development. 2006
  PubMed ID: 16368929
   
  
• Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
  Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
  Genome Res. 2006
  PubMed ID: 16344560
   
  
• Wnt3a links left-right determination with segmentation and anteroposterior axis elongation.
  Nakaya MA, Biris K, Tsukiyama T, Jaime S, Rawls JA, Yamaguchi TP
  Development. 2005
  PubMed ID: 16291790
   
  
• Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis.
  Chu J, Ding J, Jeays-Ward K, Price SM, Placzek M, Shen MM
  Development. 2005
  PubMed ID: 16291788
   
  
• Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm.
  Kimura-Yoshida C, Nakano H, Okamura D, Nakao K, Yonemura S, Belo JA, Aizawa S, Matsui Y, Matsuo I
  Dev Cell. 2005
  PubMed ID: 16256739
   
  
• Netrin-1 regulates invasion and migration of mouse mammary epithelial cells overexpressing Cripto-1 in vitro and in vivo.
  Strizzi L, Bianco C, Raafat A, Abdallah W, Chang C, Raafat D, Hirota M, Hamada S, Sun Y, Normanno N, Callahan R, Hinck L, Salomon D
  J Cell Sci. 2005
  PubMed ID: 16176936
   
  
• A human protein-protein interaction network: a resource for annotating the proteome.
  Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
  Cell. 2005
  PubMed ID: 16169070
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis.
  Sun Y, Strizzi L, Raafat A, Hirota M, Bianco C, Feigenbaum L, Kenney N, Wechselberger C, Callahan R, Salomon DS
  Am J Pathol. 2005
  PubMed ID: 16049342
   
  
• Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma.
  Wechselberger C, Strizzi L, Kenney N, Hirota M, Sun Y, Ebert A, Orozco O, Bianco C, Khan NI, Wallace-Jones B, Normanno N, Adkins H, Sanicola M, Salomon DS
  Oncogene. 2005
  PubMed ID: 15897912
   
  
• The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development.
  Gotoh N, Manova K, Tanaka S, Murohashi M, Hadari Y, Lee A, Hamada Y, Hiroe T, Ito M, Kurihara T, Nakazato H, Shibuya M, Lax I, Lacy E, Schlessinger J
  Mol Cell Biol. 2005
  PubMed ID: 15870281
   
  
• Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning.
  Donnison M, Beaton A, Davey HW, Broadhurst R, L'Huillier P, Pfeffer PL
  Development. 2005
  PubMed ID: 15829518
   
  
• Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos.
  Tao Q, Yokota C, Puck H, Kofron M, Birsoy B, Yan D, Asashima M, Wylie CC, Lin X, Heasman J
  Cell. 2005
  PubMed ID: 15797385
   
  
• The DNA sequence of the human X chromosome.
  Ross MT, Grafham DV, Coffey AJ, Scherer S, McLay K, Muzny D, Platzer M, Howell GR, Burrows C, Bird CP, Frankish A, Lovell FL, Howe KL, Ashurst JL, Fulton RS, Sudbrak R, Wen G, Jones MC, Hurles ME, Andrews TD, Scott CE, Searle S, Ramser J, Whittaker A, Deadman R, Carter NP, Hunt SE, Chen R, Cree A, Gunaratne P, Havlak P, Hodgson A, Metzker ML, Richards S, Scott G, Steffen D, Sodergren E, Wheeler DA, Worley KC, Ainscough R, Ambrose KD, Ansari-Lari MA, Aradhya S, Ashwell RI, Babbage AK, Bagguley CL, Ballabio A, Banerjee R, Barker GE, Barlow KF, Barrett IP, Bates KN, Beare DM, Beasley H, Beasley O, Beck A, Bethel G, Blechschmidt K, Brady N, Bray-Allen S, Bridgeman AM, Brown AJ, Brown MJ, Bonnin D, Bruford EA, Buhay C, Burch P, Burford D, Burgess J, Burrill W, Burton J, Bye JM, Carder C, Carrel L, Chako J, Chapman JC, Chavez D, Chen E, Chen G, Chen Y, Chen Z, Chinault C, Ciccodicola A, Clark SY, Clarke G, Clee CM, Clegg S, Clerc-Blankenburg K, Clifford K, Cobley V, Cole CG, Conquer JS, Corby N, Connor RE, David R, Davies J, Davis C, Davis J, Delgado O, Deshazo D, Dhami P, Ding Y, Dinh H, Dodsworth S, Draper H, Dugan-Rocha S, Dunham A, Dunn M, Durbin KJ, Dutta I, Eades T, Ellwood M, Emery-Cohen A, Errington H, Evans KL, Faulkner L, Francis F, Frankland J, Fraser AE, Galgoczy P, Gilbert J, Gill R, Glöckner G, Gregory SG, Gribble S, Griffiths C, Grocock R, Gu Y, Gwilliam R, Hamilton C, Hart EA, Hawes A, Heath PD, Heitmann K, Hennig S, Hernandez J, Hinzmann B, Ho S, Hoffs M, Howden PJ, Huckle EJ, Hume J, Hunt PJ, Hunt AR, Isherwood J, Jacob L, Johnson D, Jones S, de Jong PJ, Joseph SS, Keenan S, Kelly S, Kershaw JK, Khan Z, Kioschis P, Klages S, Knights AJ, Kosiura A, Kovar-Smith C, Laird GK, Langford C, Lawlor S, Leversha M, Lewis L, Liu W, Lloyd C, Lloyd DM, Loulseged H, Loveland JE, Lovell JD, Lozado R, Lu J, Lyne R, Ma J, Maheshwari M, Matthews LH, McDowall J, McLaren S, McMurray A, Meidl P, Meitinger T, Milne S, Miner G, Mistry SL, Morgan M, Morris S, Müller I, Mullikin JC, Nguyen N, Nordsiek G, Nyakatura G, O'Dell CN, Okwuonu G, Palmer S, Pandian R, Parker D, Parrish J, Pasternak S, Patel D, Pearce AV, Pearson DM, Pelan SE, Perez L, Porter KM, Ramsey Y, Reichwald K, Rhodes S, Ridler KA, Schlessinger D, Schueler MG, Sehra HK, Shaw-Smith C, Shen H, Sheridan EM, Shownkeen R, Skuce CD, Smith ML, Sotheran EC, Steingruber HE, Steward CA, Storey R, Swann RM, Swarbreck D, Tabor PE, Taudien S, Taylor T, Teague B, Thomas K, Thorpe A, Timms K, Tracey A, Trevanion S, Tromans AC, d'Urso M, Verduzco D, Villasana D, Waldron L, Wall M, Wang Q, Warren J, Warry GL, Wei X, West A, Whitehead SL, Whiteley MN, Wilkinson JE, Willey DL, Williams G, Williams L, Williamson A, Williamson H, Wilming L, Woodmansey RL, Wray PW, Yen J, Zhang J, Zhou J, Zoghbi H, Zorilla S, Buck D, Reinhardt R, Poustka A, Rosenthal A, Lehrach H, Meindl A, Minx PJ, Hillier LW, Willard HF, Wilson RK, Waterston RH, Rice CM, Vaudin M, Coulson A, Nelson DL, Weinstock G, Sulston JE, Durbin R, Hubbard T, Gibbs RA, Beck S, Rogers J, Bentley DR
  Nature. 2005
  PubMed ID: 15772651
   
  
• Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells.
  Sonntag KC, Simantov R, Björklund L, Cooper O, Pruszak J, Kowalke F, Gilmartin J, Ding J, Hu YP, Shen MM, Isacson O
  Mol Cell Neurosci. 2005
  PubMed ID: 15737733
   
  
• Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway.
  Wang X, Merritt AJ, Seyfried J, Guo C, Papadakis ES, Finegan KG, Kayahara M, Dixon J, Boot-Handford RP, Cartwright EJ, Mayer U, Tournier C
  Mol Cell Biol. 2005
  PubMed ID: 15601854
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• Signal peptide prediction based on analysis of experimentally verified cleavage sites.
  Zhang Z, Henzel WJ
  Protein Sci. 2004
  PubMed ID: 15340161
   
  
• Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning.
  Lu CC, Robertson EJ
  Dev Biol. 2004
  PubMed ID: 15302604
   
  
• Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
  Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
  Nature. 2004
  PubMed ID: 15057822
   
  
• Tcf3: a transcriptional regulator of axis induction in the early embryo.
  Merrill BJ, Pasolli HA, Polak L, Rendl M, García-García MJ, Anderson KV, Fuchs E
  Development. 2004
  PubMed ID: 14668413
   
  
• Cripto-1 overexpression leads to enhanced invasiveness and resistance to anoikis in human MCF-7 breast cancer cells.
  Normanno N, De Luca A, Bianco C, Maiello MR, Carriero MV, Rehman A, Wechselberger C, Arra C, Strizzi L, Sanicola M, Salomon DS
  J Cell Physiol. 2004
  PubMed ID: 14584041
   
  
• Anterior neural plate regionalization in cripto null mutant mouse embryos in the absence of node and primitive streak.
  Liguori GL, Echevarría D, Improta R, Signore M, Adamson E, Martínez S, Persico MG
  Dev Biol. 2003
  PubMed ID: 14651936
   
  
• Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.
  Xiao C, Shim JH, Klüppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S
  Genes Dev. 2003
  PubMed ID: 14633973
   
  
• Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.
  Morkel M, Huelsken J, Wakamiya M, Ding J, van de Wetering M, Clevers H, Taketo MM, Behringer RR, Shen MM, Birchmeier W
  Development. 2003
  PubMed ID: 14623818
   
  
• Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
  Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 14610273
   
  
• Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells.
  Parisi S, D'Andrea D, Lago CT, Adamson ED, Persico MG, Minchiotti G
  J Cell Biol. 2003
  PubMed ID: 14581455
   
  
• Whole-embryo culture of E5.5 mouse embryos: development to the gastrulation stage.
  Miura S, Mishina Y
  Genesis. 2003
  PubMed ID: 14502576
   
  
• The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis.
  Foley SF, van Vlijmen HW, Boynton RE, Adkins HB, Cheung AE, Singh J, Sanicola M, Young CN, Wen D
  Eur J Biochem. 2003
  PubMed ID: 12919325
   
  
• Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling.
  Robertson EJ, Norris DP, Brennan J, Bikoff EK
  Philos Trans R Soc Lond B Biol Sci. 2003
  PubMed ID: 14511481
   
  
• A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
  Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 12904583
   
  
• Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo.
  Adkins HB, Bianco C, Schiffer SG, Rayhorn P, Zafari M, Cheung AE, Orozco O, Olson D, De Luca A, Chen LL, Miatkowski K, Benjamin C, Normanno N, Williams KP, Jarpe M, LePage D, Salomon D, Sanicola M
  J Clin Invest. 2003
  PubMed ID: 12925698
   
  
• Cripto forms a complex with activin and type II activin receptors and can block activin signaling.
  Gray PC, Harrison CA, Vale W
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 12682303
   
  
• A Nodal- and ALK4-independent signaling pathway activated by Cripto-1 through Glypican-1 and c-Src.
  Bianco C, Strizzi L, Rehman A, Normanno N, Wechselberger C, Sun Y, Khan N, Hirota M, Adkins H, Williams K, Margolis RU, Sanicola M, Salomon DS
  Cancer Res. 2003
  PubMed ID: 12649175
   
  
• Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity.
  Hsieh JC, Lee L, Zhang L, Wefer S, Brown K, DeRossi C, Wines ME, Rosenquist T, Holdener BC
  Cell. 2003
  PubMed ID: 12581525
   
  
• BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
  Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
  Nucleic Acids Res. 2003
  PubMed ID: 12520002
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
  Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1.
  Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM
  Science. 2002
  PubMed ID: 12471260
   
  
• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
  Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
  Nature. 2002
  PubMed ID: 12466851
   
  
• Extraembryonic proteases regulate Nodal signalling during gastrulation.
  Beck S, Le Good JA, Guzman M, Ben Haim N, Roy K, Beermann F, Constam DB
  Nat Cell Biol. 2002
  PubMed ID: 12447384
   
  
• Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo.
  Hanna LA, Foreman RK, Tarasenko IA, Kessler DS, Labosky PA
  Genes Dev. 2002
  PubMed ID: 12381664
   
  
• Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6.
  Mitchem KL, Hibbard E, Beyer LA, Bosom K, Dootz GA, Dolan DF, Johnson KR, Raphael Y, Kohrman DC
  Hum Mol Genet. 2002
  PubMed ID: 12140191
   
  
• Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects.
  Regan CP, Li W, Boucher DM, Spatz S, Su MS, Kuida K
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12093914
   
  
• The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo.
  Norris DP, Brennan J, Bikoff EK, Robertson EJ
  Development. 2002
  PubMed ID: 12091315
   
  
• Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.
  Yan YT, Liu JJ, Luo Y, E C, Haltiwanger RS, Abate-Shen C, Shen MM
  Mol Cell Biol. 2002
  PubMed ID: 12052855
   
  
• A loss-of-function mutation in the CFC domain of TDGF1 is associated with human forebrain defects.
  de la Cruz JM, Bamford RN, Burdine RD, Roessler E, Barkovich AJ, Donnai D, Schier AF, Muenke M
  Hum Genet. 2002
  PubMed ID: 12073012
   
  
• Role of the EGF-CFC gene cripto in cell differentiation and embryo development.
  Minchiotti G, Parisi S, Liguori GL, D'Andrea D, Persico MG
  Gene. 2002
  PubMed ID: 11992720
   
  
• Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells.
  Bianco C, Adkins HB, Wechselberger C, Seno M, Normanno N, De Luca A, Sun Y, Khan N, Kenney N, Ebert A, Williams KP, Sanicola M, Salomon DS
  Mol Cell Biol. 2002
  PubMed ID: 11909953
   
  
• Cripto: a tumor growth factor and more.
  Adamson ED, Minchiotti G, Salomon DS
  J Cell Physiol. 2002
  PubMed ID: 11857442
   
  
• Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.
  Tian E, Kimura C, Takeda N, Aizawa S, Matsuo I
  Dev Biol. 2002
  PubMed ID: 11820816
   
  
• Detection and localization of Cripto-1 binding in mouse mammary epithelial cells and in the mouse mammary gland using an immunoglobulin-cripto-1 fusion protein.
  Bianco C, Normanno N, De Luca A, Maiello MR, Wechselberger C, Sun Y, Khan N, Adkins H, Sanicola M, Vonderhaar B, Cohen B, Seno M, Salomon D
  J Cell Physiol. 2002
  PubMed ID: 11807813
   
  
• Cripto in tumors and embryo development.
  Persico MG, Liguori GL, Parisi S, D'Andrea D, Salomon DS, Minchiotti G
  Biochim Biophys Acta. 2001
  PubMed ID: 11825688
   
  
• The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development.
  Reissmann E, Jörnvall H, Blokzijl A, Andersson O, Chang C, Minchiotti G, Persico MG, Ibáñez CF, Brivanlou AH
  Genes Dev. 2001
  PubMed ID: 11485994
   
  
• Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast.
  Kimura C, Shen MM, Takeda N, Aizawa S, Matsuo I
  Dev Biol. 2001
  PubMed ID: 11412024
   
  
• Nodal signalling in the epiblast patterns the early mouse embryo.
  Brennan J, Lu CC, Norris DP, Rodriguez TA, Beddington RS, Robertson EJ
  Nature. 2001
  PubMed ID: 11418863
   
  
• Conversion of threonine 757 to valine enhances Stat5a transactivation potential.
  Gowri PM, Ganguly TC, Cao J, Devalaraja MN, Groner B, Vore M
  J Biol Chem. 2001
  PubMed ID: 11133982
   
  
• Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo.
  Perea-Gomez A, Lawson KA, Rhinn M, Zakin L, Brûlet P, Mazan S, Ang SL
  Development. 2001
  PubMed ID: 11171400
   
  
• Functional annotation of a full-length mouse cDNA collection.
  Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
  Nature. 2001
  PubMed ID: 11217851
   
  
• RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
  Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
  Genome Res. 2000
  PubMed ID: 11076861
   
  
• Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
  Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
  Genome Res. 2000
  PubMed ID: 11042159
   
  
• Visceral endoderm mediates forebrain development by suppressing posteriorizing signals.
  Kimura C, Yoshinaga K, Tian E, Suzuki M, Aizawa S, Matsuo I
  Dev Biol. 2000
  PubMed ID: 10985852
   
  
• Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
  Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
  Proc Natl Acad Sci U S A. 2000
  PubMed ID: 10922068
   
  
• BMP type II receptor is required for gastrulation and early development of mouse embryos.
  Beppu H, Kawabata M, Hamamoto T, Chytil A, Minowa O, Noda T, Miyazono K
  Dev Biol. 2000
  PubMed ID: 10772805
   
  
• Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development.
  Minchiotti G, Parisi S, Liguori G, Signore M, Lania G, Adamson ED, Lago CT, Persico MG
  Mech Dev. 2000
  PubMed ID: 10640699
   
  
• Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis.
  Brown D, Wagner D, Li X, Richardson JA, Olson EN
  Development. 1999
  PubMed ID: 10477299
   
  
• Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells.
  Ebert AD, Wechselberger C, Frank S, Wallace-Jones B, Seno M, Martinez-Lacaci I, Bianco C, De Santis M, Weitzel HK, Salomon DS
  Cancer Res. 1999
  PubMed ID: 10493495
   
  
• Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes.
  Xu C, Liguori G, Persico MG, Adamson ED
  Development. 1999
  PubMed ID: 9876177
   
  
• Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1.
  Scognamiglio B, Baldassarre G, Cassano C, Tucci M, Montuori N, Dono R, Lembo G, Barra A, Lago CT, Viglietto G, Rocchi M, Persico MG
  Cytogenet Cell Genet. 1999
  PubMed ID: 10393436
   
  
• High-efficiency full-length cDNA cloning.
  Carninci P, Hayashizaki Y
  Methods Enzymol. 1999
  PubMed ID: 10349636
   
  
• Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia.
  Salomon DS, Bianco C, De Santis M
  Bioessays. 1999
  PubMed ID: 10070255
   
  
• Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
  Ko MS, Threat TA, Wang X, Horton JH, Cui Y, Wang X, Pryor E, Paris J, Wells-Smith J, Kitchen JR, Rowe LB, Eppig J, Satoh T, Brant L, Fujiwara H, Yotsumoto S, Nakashima H
  Hum Mol Genet. 1998
  PubMed ID: 9811942
   
  
• Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo.
  Ding J, Yang L, Yan YT, Chen A, Desai N, Wynshaw-Boris A, Shen MM
  Nature. 1998
  PubMed ID: 9790191
   
  
• Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1.
  Xu C, Liguori G, Adamson ED, Persico MG
  Dev Biol. 1998
  PubMed ID: 9576836
   
  
• Mapping of the mouse Tdgf1 gene and Tdgf pseudogenes.
  Liguori G, De Gregorio L, Tucci M, Lago CT, Barra A, Dragani TA, Persico M
  Mamm Genome. 1997
  PubMed ID: 9195995
   
  
• Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells.
  Kannan S, De Santis M, Lohmeyer M, Riese DJ, Smith GH, Hynes N, Seno M, Brandt R, Bianco C, Persico G, Kenney N, Normanno N, Martinez-Lacaci I, Ciardiello F, Stern DF, Gullick WJ, Salomon DS
  J Biol Chem. 1997
  PubMed ID: 9013573
   
  
• A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation.
  Shen MM, Wang H, Leder P
  Development. 1997
  PubMed ID: 9053319
   
  
• Characterization of the mouse Tdgf1 gene and Tdgf pseudogenes.
  Liguori G, Tucci M, Montuori N, Dono R, Lago CT, Pacifico F, Armenante F, Persico MG
  Mamm Genome. 1996
  PubMed ID: 8661720
   
  
• Differential immunohistochemical detection of transforming growth factor alpha, amphiregulin and CRIPTO in human normal and malignant breast tissues.
  Panico L, D'Antonio A, Salvatore G, Mezza E, Tortora G, De Laurentiis M, De Placido S, Giordano T, Merino M, Salomon DS, Mullick WJ, Pettinato G, Schnitt SJ, Bianco AR, Ciardiello F
  Int J Cancer. 1996
  PubMed ID: 8543395
   
  
• Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation.
  Acampora D, Mazan S, Lallemand Y, Avantaggiato V, Maury M, Simeone A, Brûlet P
  Development. 1995
  PubMed ID: 7588062
   
  
• Detection and location of amphiregulin and Cripto-1 expression in the developing postnatal mouse mammary gland.
  Kenney NJ, Huang RP, Johnson GR, Wu JX, Okamura D, Matheny W, Kordon E, Gullick WJ, Plowman G, Smith GH
  Mol Reprod Dev. 1995
  PubMed ID: 8588926
   
  
• Regional localization of the human EGF-like growth factor CRIPTO gene (TDGF-1) to chromosome 3p21.
  Saccone S, Rapisarda A, Motta S, Dono R, Persico GM, Della Valle G
  Hum Genet. 1995
  PubMed ID: 7860072
   
  
• Expression of epidermal growth factor family gene members in early mouse development.
  Johnson SE, Rothstein JL, Knowles BB
  Dev Dyn. 1994
  PubMed ID: 7881126
   
  
• Identification and biological characterization of an epidermal growth factor-related protein: cripto-1.
  Brandt R, Normanno N, Gullick WJ, Lin JH, Harkins R, Schneider D, Jones BW, Ciardiello F, Persico MG, Armenante F
  J Biol Chem. 1994
  PubMed ID: 8006041
   
  
• Cripto, a member of the epidermal growth factor family, is over-expressed in human pancreatic cancer and chronic pancreatitis.
  Friess H, Yamanaka Y, Büchler M, Kobrin MS, Tahara E, Korc M
  Int J Cancer. 1994
  PubMed ID: 8314343
   
  
• The murine cripto gene: expression during mesoderm induction and early heart morphogenesis.
  Dono R, Scalera L, Pacifico F, Acampora D, Persico MG, Simeone A
  Development. 1993
  PubMed ID: 7916676
   
  
• Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence.
  Dono R, Montuori N, Rocchi M, De Ponti-Zilli L, Ciccodicola A, Persico MG
  Am J Hum Genet. 1991
  PubMed ID: 1882841
   
  
• Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells.
  Ciccodicola A, Dono R, Obici S, Simeone A, Zollo M, Persico MG
  EMBO J. 1989
  PubMed ID: 2792079
   
  

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