BUB1

Summary Top Help

Gene Description:

budding uninhibited by benzimidazoles 1 homolog (yeast); budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)

Synonyms:

hBUB1, Bub1, BUB1A, BUB1, C80208, AL022991, D2Xrf87, Bub1a, BUB1L

Orthologs:

Human BUB1 (protein-coding), Mouse Bub1 (protein-coding), Rat Bub1 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1 Rat: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd13	Mouse	chr2:114118625..158330390	44.21	582	3 no lod score

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm27	Rat	chr3:96506745..149496698	52.99	606

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr2:111395275..111435691 (40.42 kb) View in Genome Browser

(Mouse) NCBIM37 - chr2:127625936..127657601 (31.66 kb) View in Genome Browser

(Rat) RGSC3.4 - chr3:115323510..115354906 (31.40 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for BUB1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
										no data		no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for BUB1:

The BUB1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
BUB1	NDC80	IntAct, BioGRID	empirical	20360068
BUB1	ARIH2	HPRD, MINT, IntAct, BioGRID	empirical	16189514
BUB1	CENPA	Reactome	predicted
BUB1	CENPE	Reactome	predicted
BUB1	CENPF	Reactome	predicted
BUB1	AP4B1	HPRD	empirical	12419313
BUB1	NUDC	Reactome	predicted
BUB1	KIF2C	Reactome	predicted
BUB1	ZWINT	IntAct, BioGRID, Reactome	empirical	20360068
BUB1	PMF1	IntAct	empirical	20360068
BUB1	CRK	HPRD, MINT, IntAct, BioGRID	empirical	16189514
BUB1	RDH12	IntAct	empirical	21988832
BUB1	SPC24	IntAct, BioGRID	empirical	20360068
BUB1	SGOL2	Reactome	predicted
BUB1	SGOL1	Reactome	predicted
BUB1	AP1B1	HPRD	empirical	12419313
BUB1	AP2B1	HPRD	empirical	12419313
BUB1	EIF4EBP1	HPRD	empirical	10198256
BUB1	SKA1	Reactome	predicted
BUB1	MAPRE1	Reactome	predicted
BUB1	CLASP2	Reactome	predicted
BUB1	CLASP1	Reactome	predicted
BUB1	AHCTF1	Reactome	predicted
BUB1	NSL1	IntAct, BioGRID	empirical	20360068
BUB1	HDAC1	HPRD, BioGRID	empirical	15388328
BUB1	APC	HPRD, BioGRID	empirical	11283619
BUB1	INCENP	Reactome	predicted
BUB1	KIF2A	Reactome	predicted
BUB1	MYC	IntAct	empirical	21150319
BUB1	PAFAH1B1	Reactome	predicted
BUB1	UBR5	IntAct, BioGRID	empirical	20360068
BUB1	PDE4D	IntAct, BioGRID	empirical	20360068
BUB1	PLK1	HPRD, Reactome	empirical	16760428
BUB1	NDE1	Reactome	predicted
BUB1	ERCC6L	Reactome	predicted
BUB1	CCDC99	Reactome	predicted
BUB1	PPP1CC	Reactome	predicted
BUB1	RCC2	Reactome	predicted
BUB1	CASC5	IntAct, BioGRID	empirical	20360068
BUB1	SPC25	IntAct, BioGRID	empirical	20360068
BUB1	TAOK1	Reactome	predicted
BUB1	RANBP2	Reactome	predicted
BUB1	RANGAP1	Reactome	predicted
BUB1	RPS27	Reactome	predicted
BUB1	CLIP1	Reactome	predicted
BUB1	SVIL	BioGRID	empirical	20309963
BUB1	BUB1	IntAct, BioGRID	empirical	20360068
BUB1	BUB1B	IntAct, BioGRID	empirical	20360068
BUB1	UBC	BioGRID	empirical	21139048
BUB1	XPO1	Reactome	predicted
BUB1	MIS12	IntAct, BioGRID	empirical	20360068
BUB1	DSN1	IntAct, BioGRID	empirical	20360068
BUB1	B9D2	Reactome	predicted
BUB1	NDEL1	IntAct, Reactome	empirical	17600710
BUB1	KIF18A	Reactome	predicted
BUB1	NUF2	IntAct, BioGRID	empirical	20360068
BUB1	MAD1L1	Reactome	predicted
BUB1	KIF2B	Reactome	predicted
BUB1	RAE1	HPRD, BioGRID	empirical	11352911
BUB1	AP3B1	HPRD	empirical	12419313
BUB1	ZW10	IntAct	empirical	15824131
BUB1	BUB3	HPRD, IntAct, BioGRID	empirical	11283619 9660858 21988832 11352911
BUB1	CKAP5	Reactome	predicted
BUB1	CDK1	HPRD	empirical	16760428
BUB1	CDC20	HPRD, IntAct, BioGRID, Reactome	empirical	15525512 20360068

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 3

Biocarta: None available

Reactome: 5

NCI-Nature Pathway Interaction Database: 3

Gene Ontology: 25

Publications from PubMed Top Help

Publications: 125

Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint.
Yang C, Tang X, Guo X, Niikura Y, Kitagawa K, Cui K, Wong ST, Fu L, Xu B
Mol Cell. 2011
PubMed ID: 22099307
Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation.
Ricke RM, Jeganathan KB, van Deursen JM
J Cell Biol. 2011
PubMed ID: 21646403
Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip.
Machold R, Klein C, Fishell G
Gene Expr Patterns. 2011
PubMed ID: 21440680
Protein interaction domain mapping of human kinetochore protein Blinkin reveals a consensus motif for binding of spindle assembly checkpoint proteins Bub1 and BubR1.
Kiyomitsu T, Murakami H, Yanagida M
Mol Cell Biol. 2011
PubMed ID: 21199919
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Reduced expression of Mad2 and Bub1 proteins is associated with spontaneous miscarriages.
Shi Q, Hu M, Luo M, Liu Q, Jiang F, Zhang Y, Wang S, Yan C, Weng Y
Mol Hum Reprod. 2011
PubMed ID: 20643875
Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol.
Radulescu S, Ridgway RA, Appleton P, Kroboth K, Patel S, Woodgett J, Taylor S, Nathke IS, Sansom OJ
Oncogene. 2010
PubMed ID: 20729907
Two histone marks establish the inner centromere and chromosome bi-orientation.
Yamagishi Y, Honda T, Tanno Y, Watanabe Y
Science. 2010
PubMed ID: 20929775
Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochores.
Xiao B, Verma SC, Cai Q, Kaul R, Lu J, Saha A, Robertson ES
J Virol. 2010
PubMed ID: 20660191
[Regulation of Bub1 mRNA expression in endometrial carcinoma Ishikawa cells by estrogen and paclitaxel].
Chen YH, Li XP, Wang Y, Wang JL, Wei LH
Zhonghua Fu Chan Ke Za Zhi. 2010
PubMed ID: 21092550
Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.
Dick DM, Meyers J, Aliev F, Nurnberger J, Kramer J, Kuperman S, Porjesz B, Tischfield J, Edenberg HJ, Foroud T, Schuckit M, Goate A, Hesselbrock V, Bierut L
Am J Med Genet B Neuropsychiatr Genet. 2010
PubMed ID: 20468071
The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis.
Li M, Fang X, Baker DJ, Guo L, Gao X, Wei Z, Han S, van Deursen JM, Zhang P
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20663956
Novel interactors and a role for supervillin in early cytokinesis.
Smith TC, Fang Z, Luna EJ
Cytoskeleton (Hoboken). 2010
PubMed ID: 20309963
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
Sgo1 establishes the centromeric cohesion protection mechanism in G2 before subsequent Bub1-dependent recruitment in mitosis.
Perera D, Taylor SS
J Cell Sci. 2010
PubMed ID: 20124418
Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin.
Kawashima SA, Yamagishi Y, Honda T, Ishiguro K, Watanabe Y
Science. 2010
PubMed ID: 19965387
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer)
PLoS Genet. 2010
PubMed ID: 20628624
Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.
Baker DJ, Jin F, Jeganathan KB, van Deursen JM
Cancer Cell. 2009
PubMed ID: 19962666
Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice.
Leland S, Nagarajan P, Polyzos A, Thomas S, Samaan G, Donnell R, Marchetti F, Venkatachalam S
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19617567
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
A nucleolar protein RRS1 contributes to chromosome congression.
Gambe AE, Matsunaga S, Takata H, Ono-Maniwa R, Baba A, Uchiyama S, Fukui K
FEBS Lett. 2009
PubMed ID: 19465021
Bub1 regulates chromosome segregation in a kinetochore-independent manner.
Klebig C, Korinth D, Meraldi P
J Cell Biol. 2009
PubMed ID: 19487456
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation.
Gao F, Ponte JF, Levy M, Papageorgis P, Cook NM, Ozturk S, Lambert AW, Thiagalingam A, Abdolmaleky HM, Sullivan BA, Thiagalingam S
Cancer Biol Ther. 2009
PubMed ID: 19252416
hBub1 deficiency triggers a novel p53 mediated early apoptotic checkpoint pathway in mitotic spindle damaged cells.
Gao F, Ponte JF, Papageorgis P, Levy M, Ozturk S, Lambert AW, Pan H, Chinnappan D, Cheng KH, Thiagalingam A, Abdolmaleky HM, Thiagalingam S
Cancer Biol Ther. 2009
PubMed ID: 19242126
Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint.
McGuinness BE, Anger M, Kouznetsova A, Gil-Bernabé AM, Helmhart W, Kudo NR, Wuensche A, Taylor S, Hoog C, Novak B, Nasmyth K
Curr Biol. 2009
PubMed ID: 19249208
TAp73alpha binds the kinetochore proteins Bub1 and Bub3 resulting in polyploidy.
Vernole P, Neale MH, Barcaroli D, Munarriz E, Knight RA, Tomasini R, Mak TW, Melino G, De Laurenzi V
Cell Cycle. 2009
PubMed ID: 19182530
Multiple anaphase-promoting complex/cyclosome degrons mediate the degradation of human Sgo1.
Karamysheva Z, Diaz-Martinez LA, Crow SE, Li B, Yu H
J Biol Chem. 2009
PubMed ID: 19015261
The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores.
Bolanos-Garcia VM, Kiyomitsu T, D'Arcy S, Chirgadze DY, Grossmann JG, Matak-Vinkovic D, Venkitaraman AR, Yanagida M, Robinson CV, Blundell TL
Structure. 2009
PubMed ID: 19141287
Inactivating the spindle checkpoint kinase Bub1 during embryonic development results in a global shutdown of proliferation.
Tilston V, Taylor SS, Perera D
BMC Res Notes. 2009
PubMed ID: 19772675
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.
Schliekelman M, Cowley DO, O'Quinn R, Oliver TG, Lu L, Salmon ED, Van Dyke T
Cancer Res. 2009
PubMed ID: 19117986
Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.
Hein J, Boichuk S, Wu J, Cheng Y, Freire R, Jat PS, Roberts TM, Gjoerup OV
J Virol. 2009
PubMed ID: 18922873
Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.
Wang B, Malik R, Nigg EA, Körner R
Anal Chem. 2008
PubMed ID: 19007248
Metaphase I arrest in LT/Sv mouse oocytes involves the spindle assembly checkpoint.
Hupalowska A, Kalaszczynska I, Hoffmann S, Tsurumi C, Kubiak JZ, Polanski Z, Ciemerych MA
Biol Reprod. 2008
PubMed ID: 18753610
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1.
Kang J, Yang M, Li B, Qi W, Zhang C, Shokat KM, Tomchick DR, Machius M, Yu H
Mol Cell. 2008
PubMed ID: 18995837
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Characterization of the tetratricopeptide-containing domain of BUB1, BUBR1, and PP5 proves that domain amphiphilicity over amino acid sequence specificity governs protein adsorption and interfacial activity.
Beaufils S, Grossmann JG, Renault A, Bolanos-Garcia VM
J Phys Chem B. 2008
PubMed ID: 18547097
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Changes in cell morphology and cytoskeletal organization are induced by human mitotic checkpoint gene, Bub1.
Ando J, Sugimoto K, Tamayose K, Sasaki M, Ando M, Oshimi K
Biochem Biophys Res Commun. 2008
PubMed ID: 18036341
Overexpression of the mitotic checkpoint genes BUB1 and BUBR1 is associated with genomic complexity in clear cell kidney carcinomas.
Pinto M, Vieira J, Ribeiro FR, Soares MJ, Henrique R, Oliveira J, Jerónimo C, Teixeira MR
Cell Oncol. 2008
PubMed ID: 18791270
Overexpression of the mitotic spindle assembly checkpoint genes hBUB1, hBUBR1 and hMAD2 in thyroid carcinomas with aggressive nature.
Wada N, Yoshida A, Miyagi Y, Yamamoto T, Nakayama H, Suganuma N, Matsuzu K, Masudo K, Hirakawa S, Rino Y, Masuda M, Imada T
Anticancer Res. 2008
PubMed ID: 18383837
Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells.
Lee J, Kitajima TS, Tanno Y, Yoshida K, Morita T, Miyano T, Miyake M, Watanabe Y
Nat Cell Biol. 2008
PubMed ID: 18084284
Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1.
Kiyomitsu T, Obuse C, Yanagida M
Dev Cell. 2007
PubMed ID: 17981135
Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.
Jeganathan K, Malureanu L, Baker DJ, Abraham SC, van Deursen JM
J Cell Biol. 2007
PubMed ID: 17938250
Bub1 maintains centromeric cohesion by activation of the spindle checkpoint.
Perera D, Tilston V, Hopwood JA, Barchi M, Boot-Handford RP, Taylor SS
Dev Cell. 2007
PubMed ID: 17925231
BUB1 mediation of caspase-independent mitotic death determines cell fate.
Niikura Y, Dixit A, Scott R, Perkins G, Kitagawa K
J Cell Biol. 2007
PubMed ID: 17620410
Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1.
Pouwels J, Kukkonen AM, Lan W, Daum JR, Gorbsky GJ, Stukenberg T, Kallio MJ
Cell Cycle. 2007
PubMed ID: 17617734
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ
Science. 2007
PubMed ID: 17525332
Surveillance mechanism linking Bub1 loss to the p53 pathway.
Gjoerup OV, Wu J, Chandler-Militello D, Williams GL, Zhao J, Schaffhausen B, Jat PS, Roberts TM
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17488820
Breast cancer risk associated with genotypic polymorphism of the mitotic checkpoint genes: a multigenic study on cancer susceptibility.
Lo YL, Yu JC, Chen ST, Hsu GC, Mau YC, Yang SL, Wu PE, Shen CY
Carcinogenesis. 2007
PubMed ID: 17210994
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen.
Bertheau P, Turpin E, Rickman DS, Espié M, de Reyniès A, Feugeas JP, Plassa LF, Soliman H, Varna M, de Roquancourt A, Lehmann-Che J, Beuzard Y, Marty M, Misset JL, Janin A, de Thé H
PLoS Med. 2007
PubMed ID: 17388661
KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome.
Qi W, Yu H
J Biol Chem. 2007
PubMed ID: 17158872
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.
Dikovskaya D, Schiffmann D, Newton IP, Oakley A, Kroboth K, Sansom O, Jamieson TJ, Meniel V, Clarke A, Näthke IS
J Cell Biol. 2007
PubMed ID: 17227893
Bub1 prevents chromosome misalignment and precocious anaphase during mouse oocyte meiosis.
Yin S, Wang Q, Liu JH, Ai JS, Liang CG, Hou Y, Chen DY, Schatten H, Sun QY
Cell Cycle. 2006
PubMed ID: 16969117
Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1.
Qi W, Tang Z, Yu H
Mol Biol Cell. 2006
PubMed ID: 16760428
Spindle checkpoint protein Bub1 corrects mitotic aberrancy induced by human T-cell leukemia virus type I Tax.
Sasaki M, Sugimoto K, Tamayose K, Ando M, Tanaka Y, Oshimi K
Oncogene. 2006
PubMed ID: 16449967
Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation.
Nagamori I, Yomogida K, Adams PD, Sassone-Corsi P, Nojima H
J Biol Chem. 2006
PubMed ID: 16595651
Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors.
Shigeishi H, Yoneda S, Taki M, Nobumori T, Ohta K, Higashikawa K, Yasui W, Kamata N
Oncol Rep. 2006
PubMed ID: 16525682
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20.
Morrow CJ, Tighe A, Johnson VL, Scott MI, Ditchfield C, Taylor SS
J Cell Sci. 2005
PubMed ID: 16046481
Human spindle checkpoint kinase Bub1 is cleaved during apoptosis.
Perera D, Freire R
Cell Death Differ. 2005
PubMed ID: 15818396
Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.
Glinsky GV, Berezovska O, Glinskii AB
J Clin Invest. 2005
PubMed ID: 15931389
A dual role for Bub1 in the spindle checkpoint and chromosome congression.
Meraldi P, Sorger PK
EMBO J. 2005
PubMed ID: 15933723
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
Nature. 2005
PubMed ID: 15815621
Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization.
Kitajima TS, Hauf S, Ohsugi M, Yamamoto T, Watanabe Y
Curr Biol. 2005
PubMed ID: 15723797
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis.
Tang Z, Sun Y, Harley SE, Zou H, Yu H
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15604152
The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes.
Tsurumi C, Hoffmann S, Geley S, Graeser R, Polanski Z
J Cell Biol. 2004
PubMed ID: 15611331
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.
Tang Z, Shu H, Oncel D, Chen S, Yu H
Mol Cell. 2004
PubMed ID: 15525512
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase.
Yoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, Hwang SG, Chun JS, Lee CW
FEBS Lett. 2004
PubMed ID: 15388328
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S
Genome Res. 2004
PubMed ID: 15342556
The E4F protein is required for mitotic progression during embryonic cell cycles.
Le Cam L, Lacroix M, Ciemerych MA, Sardet C, Sicinski P
Mol Cell Biol. 2004
PubMed ID: 15226446
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
Differential expression of the MAD2, BUB1 and HSP27 genes in Barrett's oesophagus-their association with aneuploidy and neoplastic progression.
Doak SH, Jenkins GJ, Parry EM, Griffiths AP, Baxter JN, Parry JM
Mutat Res. 2004
PubMed ID: 15013707
Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression.
Johnson VL, Scott MI, Holt SV, Hussein D, Taylor SS
J Cell Sci. 2004
PubMed ID: 15020684
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas.
Lee H
Exp Mol Med. 2003
PubMed ID: 14646599
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Inhibition of BUB1 results in genomic instability and anchorage-independent growth of normal human fibroblasts.
Musio A, Montagna C, Zambroni D, Indino E, Barbieri O, Citti L, Villa A, Ried T, Vezzoni P
Cancer Res. 2003
PubMed ID: 12782591
A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T.
Hempen PM, Kurpad H, Calhoun ES, Abraham S, Kern SE
Hum Mutat. 2003
PubMed ID: 12655561
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1.
Cayrol C, Cougoule C, Wright M
Biochem Biophys Res Commun. 2002
PubMed ID: 12419313
No mutations of the Bub1 gene in human gastric and oral cancer cell lines.
Nakagawa H, Yokozaki H, Oue N, Sugiyama M, Ishikawa T, Tahara E, Yasui W
Oncol Rep. 2002
PubMed ID: 12375025
Simultaneous analysis of chromosomes and chromosome-associated proteins in mammalian oocytes and embryos.
Hodges CA, Hunt PA
Chromosoma. 2002
PubMed ID: 12355205
hBUB1 defects in leukemia and lymphoma cells.
Ru HY, Chen RL, Lu WC, Chen JH
Oncogene. 2002
PubMed ID: 12096343
Expression of hBUB1 in acute myeloid leukemia.
Lin SF, Lin PM, Yang MC, Liu TC, Chang JG, Sue YC, Chen TP
Leuk Lymphoma. 2002
PubMed ID: 11999574
Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival.
Shichiri M, Yoshinaga K, Hisatomi H, Sugihara K, Hirata Y
Cancer Res. 2002
PubMed ID: 11782350
Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells.
Taylor SS, Hussein D, Wang Y, Elderkin S, Morrow CJ
J Cell Sci. 2001
PubMed ID: 11792804
The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins.
Wang X, Babu JR, Harden JM, Jablonski SA, Gazi MH, Lingle WL, de Groen PC, Yen TJ, van Deursen JM
J Biol Chem. 2001
PubMed ID: 11352911
A role for the Adenomatous Polyposis Coli protein in chromosome segregation.
Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, Näthke IS
Nat Cell Biol. 2001
PubMed ID: 11283619
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Association between spindle assembly checkpoint expression and maternal age in human oocytes.
Steuerwald N, Cohen J, Herrera RJ, Sandalinas M, Brenner CA
Mol Hum Reprod. 2001
PubMed ID: 11134360
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genomic instability at the BUB1 locus in colorectal cancer, but not in non-small cell lung cancer.
Jaffrey RG, Pritchard SC, Clark C, Murray GI, Cassidy J, Kerr KM, Nicolson MC, McLeod HL
Cancer Res. 2000
PubMed ID: 10969775
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
Retention of the BUB3 checkpoint protein on lagging chromosomes.
Martinez-Exposito MJ, Kaplan KB, Copeland J, Sorger PK
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10411903
Characterization of MAD2B and other mitotic spindle checkpoint genes.
Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B, Lengauer C
Genomics. 1999
PubMed ID: 10366450
Phosphorylation of human MAD1 by the BUB1 kinase in vitro.
Seeley TW, Wang L, Zhen JY
Biochem Biophys Res Commun. 1999
PubMed ID: 10198256
The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner.
Davenport JW, Fernandes ER, Harris LD, Neale GA, Goorha R
Genomics. 1999
PubMed ID: 9889005
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis.
Jablonski SA, Chan GK, Cooke CA, Earnshaw WC, Yen TJ
Chromosoma. 1998
PubMed ID: 9914370
Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation.
Ouyang B, Lan Z, Meadows J, Pan H, Fukasawa K, Li W, Dai W
Cell Growth Differ. 1998
PubMed ID: 9790499
The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase.
Taylor SS, Ha E, McKeon F
J Cell Biol. 1998
PubMed ID: 9660858
Mutations of mitotic checkpoint genes in human cancers.
Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B
Nature. 1998
PubMed ID: 9521327
Mammalian BUB1 protein kinases: map positions and in vivo expression.
Pangilinan F, Li Q, Weaver T, Lewis BC, Dang CV, Spencer F
Genomics. 1997
PubMed ID: 9441741
Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
Gene. 1997
PubMed ID: 9373149
Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage.
Taylor SS, McKeon F
Cell. 1997
PubMed ID: 9182760
Ott, a mouse X-linked multigene family expressed specifically during meiosis.
Kerr SM, Taggart MH, Lee M, Cooke HJ
Hum Mol Genet. 1996
PubMed ID: 8842733
Comparative genomics, genome cross-referencing and XREFdb.
Bassett DE, Boguski MS, Spencer F, Reeves R, Goebl M, Hieter P
Trends Genet. 1995
PubMed ID: 7482790
Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.
Harrison SM, Dunwoodie SL, Arkell RM, Lehrach H, Beddington RS
Development. 1995
PubMed ID: 7671812
Analysis of cDNA sequences from mouse testis.
Kerr SM, Vambrie S, McKay SJ, Cooke HJ
Mamm Genome. 1994
PubMed ID: 8000140
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
PubMed ID: 8125298

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	699	12235	296137
EnsEMBL Gene(s)	ENSG00000169679	ENSMUSG00000027379	ENSRNOG00000032778
Unigene	Hs.469649	Mm.2185	Rn.56816
Homologene	BUB1	Bub1	Bub1
OMIM	602452	N/A	N/A
GeneCards	BUB1	N/A	N/A
Beta Cell Genomics	DT.100646001 DT.112990 DT.121000041 DT.97844027	DT.530175 DT.91305638	N/A
Reactome	O43683	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	699	12235	296137

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