TCF3

Summary Top Help

Gene Description:

transcription factor 3; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)

Synonyms:

E12, bHLHb21, A1, AA408400, E47, VDIR, ALF2, Tcfe2a, ME2, TCF-3, Tcf3, TCF3, ITF1, Pan1, E12/E47, AW209082, E2A, Pan2

Orthologs:

Human TCF3 (protein-coding), Mouse Tcf3 (protein-coding), Rat Tcfe2a (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr19:1609289..1652328 (434 kb) View in Genome Browser

(Mouse) NCBIM37 - chr10:79871910..79896398 (24.49 kb) View in Genome Browser

(Rat) RGSC3.4 - chr7:10791311..10813613 (22.30 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for TCF3:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for TCF3:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: 2

NCI-Nature Pathway Interaction Database: 3

Gene Ontology: 45

G1 phase of mitotic cell cycle	GO:0000080
Nuclear nucleosome	GO:0000788
Natural killer cell differentiation	GO:0001779
B cell lineage commitment	GO:0002326
DNA binding	GO:0003677
Chromatin binding	GO:0003682
Sequence-specific DNA binding transcription factor activity	GO:0003700
Transcription coactivator activity	GO:0003713
Protein binding	GO:0005515
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Transcription factor complex	GO:0005667
Cytoplasm	GO:0005737
Transcription, DNA-dependent	GO:0006351
Regulation of transcription, DNA-dependent	GO:0006355
Nervous system development	GO:0007399
Transcription factor binding	GO:0008134
B cell differentiation	GO:0030183
Positive regulation of B cell proliferation	GO:0030890
Mitogen-activated protein kinase kinase kinase binding	GO:0031435
Response to lipopolysaccharide	GO:0032496
T cell differentiation in thymus	GO:0033077
Immunoglobulin V(D)J recombination	GO:0033152
Response to drug	GO:0042493
Muscle cell differentiation	GO:0042692
Protein homodimerization activity	GO:0042803
Protein complex	GO:0043234
BHLH transcription factor binding	GO:0043425
Sequence-specific DNA binding	GO:0043565
Histone H3 acetylation	GO:0043966
Histone H4 acetylation	GO:0043967
Transcription regulatory region DNA binding	GO:0044212
Positive regulation of neuron differentiation	GO:0045666
Positive regulation of cell cycle	GO:0045787
Positive regulation of transcription, DNA-dependent	GO:0045893
Positive regulation of transcription from RNA polymerase II promoter	GO:0045944
Protein heterodimerization activity	GO:0046982
Cell development	GO:0048468
Peyer's patch development	GO:0048541
Protein stabilization	GO:0050821
Positive regulation of sequence-specific DNA binding transcription factor activity	GO:0051091
Positive regulation of muscle cell differentiation	GO:0051149
Repressing transcription factor binding	GO:0070491
Vitamin D response element binding	GO:0070644
E-box binding	GO:0070888

Publications from PubMed Top Help

Type 1 Diabetes Publications: 13

Menin promotes the Wnt signaling pathway in pancreatic endocrine cells.
Chen G, A J, Wang M, Farley S, Lee LY, Lee LC, Sawicki MP
Mol Cancer Res. 2008
PubMed ID: 19074834
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.
Masui T, Long Q, Beres TM, Magnuson MA, MacDonald RJ
Genes Dev. 2007
PubMed ID: 17938243
Transcription factor cycling on the insulin promoter.
Barrow J, Hay CW, Ferguson LA, Docherty HM, Docherty K
FEBS Lett. 2006
PubMed ID: 16412423
Activin A-induced expression of PAX4 in AR42J-B13 cells involves the increase in transactivation of E47/E12.
Kanno R, Ogihara T, Igarashi Y, Tanaka Y, Smith SB, Kojima I, German MS, Kawamori R, Watada H
Biochim Biophys Acta. 2006
PubMed ID: 16546275
Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.
Amemiya-Kudo M, Oka J, Ide T, Matsuzaka T, Sone H, Yoshikawa T, Yahagi N, Ishibashi S, Osuga J, Yamada N, Murase T, Shimano H
J Biol Chem. 2005
PubMed ID: 16055439
Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.
Kim JY, Chu K, Kim HJ, Seong HA, Park KC, Sanyal S, Takeda J, Ha H, Shong M, Tsai MJ, Choi HS
Mol Endocrinol. 2004
PubMed ID: 14752053
Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter.
Glick E, Leshkowitz D, Walker MD
J Biol Chem. 2000
PubMed ID: 10636926
Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription.
Thomas MK, Yao KM, Tenser MS, Wong GG, Habener JF
Mol Cell Biol. 1999
PubMed ID: 10567574
Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus.
Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH, Montminy M, Krolewski AS
Nat Genet. 1999
PubMed ID: 10545951
Ubiquitous, but variable, expression of two alternatively spliced mRNAs encoding mouse homologues of transcription factors E47 and E12.
Watada H, Kajimoto Y, Umayahara Y, Matsuoka T, Morishima T, Yamasaki Y, Kawamori R, Kamada T
Gene. 1995
PubMed ID: 7875598
Isolation and characterization of a novel transcription factor that binds to and activates insulin control element-mediated expression.
Robinson GL, Cordle SR, Henderson E, Weil PA, Teitelman G, Stein R
Mol Cell Biol. 1994
PubMed ID: 7935390
Cell-specific expression of helix-loop-helix transcription factors encoded by the E2A gene.
Aronheim A, Shiran R, Rosen A, Walker MD
Nucleic Acids Res. 1993
PubMed ID: 8479911
A cDNA from a mouse pancreatic beta cell encoding a putative transcription factor of the insulin gene.
Walker MD, Park CW, Rosen A, Aronheim A
Nucleic Acids Res. 1990
PubMed ID: 2181401

Publications: 351

Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells.
Ji Y, Pos Z, Rao M, Klebanoff CA, Yu Z, Sukumar M, Reger RN, Palmer DC, Borman ZA, Muranski P, Wang E, Schrump DS, Marincola FM, Restifo NP, Gattinoni L
Nat Immunol. 2011
PubMed ID: 22057288
HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain.
Andoniadou CL, Signore M, Young RM, Gaston-Massuet C, Wilson SW, Fuchs E, Martinez-Barbera JP
Development. 2011
PubMed ID: 22007134
The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor.
Welinder E, Mansson R, Mercer EM, Bryder D, Sigvardsson M, Murre C
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21972416
The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells.
Miyazaki M, Rivera RR, Miyazaki K, Lin YC, Agata Y, Murre C
Nat Immunol. 2011
PubMed ID: 21857655
Cross-talk between distinct nuclear import pathways enables efficient nuclear import of E47 in conjunction with its partner transcription factors.
Mehmood R, Yasuhara N, Fukumoto M, Oe S, Tachibana T, Yoneda Y
Mol Biol Cell. 2011
PubMed ID: 21832153
Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS.
Wang H, Lei Q, Oosterveen T, Ericson J, Matise MP
Development. 2011
PubMed ID: 21775418
TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis.
Petersson M, Brylka H, Kraus A, John S, Rappl G, Schettina P, Niemann C
EMBO J. 2011
PubMed ID: 21694721
RT-PCR and real-time PCR analysis of E2A-PBX1, TEL-AML1, mBCR-ABL and MLL-AF4 fusion gene transcripts in de novo B-lineage acute lymphoblastic leukaemia patients in south India.
Sudhakar N, Rajalekshmy KR, Rajkumar T, Nancy KN
J Genet. 2011
PubMed ID: 21869488
HEB and E2A function as SMAD/FOXH1 cofactors.
Yoon SJ, Wills AE, Chuong E, Gupta R, Baker JC
Genes Dev. 2011
PubMed ID: 21828274
Genomic loss of the putative tumor suppressor gene E2A in human lymphoma.
Steininger A, Möbs M, Ullmann R, Köchert K, Kreher S, Lamprecht B, Anagnostopoulos I, Hummel M, Richter J, Beyer M, Janz M, Klemke CD, Stein H, Dörken B, Sterry W, Schrock E, Mathas S, Assaf C
J Exp Med. 2011
PubMed ID: 21788410
T-cell factor 3 (Tcf3) deletion increases somatic cell reprogramming by inducing epigenome modifications.
Lluis F, Ombrato L, Pedone E, Pepe S, Merrill BJ, Cosma MP
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21730189
Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal.
Yi F, Pereira L, Hoffman JA, Shy BR, Yuen CM, Liu DR, Merrill BJ
Nat Cell Biol. 2011
PubMed ID: 21685894
Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation.
Wray J, Kalkan T, Gomez-Lopez S, Eckardt D, Cook A, Kemler R, Smith A
Nat Cell Biol. 2011
PubMed ID: 21685889
Prognostic impact of t(1;19)/ TCF3-PBX1 in childhood acute lymphoblastic leukemia in the context of Berlin-Frankfurt-Münster-based protocols.
Felice MS, Gallego MS, Alonso CN, Alfaro EM, Guitter MR, Bernasconi AR, Rubio PL, Zubizarreta PA, Rossi JG
Leuk Lymphoma. 2011
PubMed ID: 21534874
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
The B lineage transcription factor E2A regulates apoptosis in chronic lymphocytic leukemia (CLL) cells.
Kardava L, Yang Q, St Leger A, Foon KA, Lentzsch S, Vallejo AN, Milcarek C, Borghesi L
Int Immunol. 2011
PubMed ID: 21551245
The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma.
Lee SH, Hao E, Kiselyuk A, Shapiro J, Shields DJ, Lowy A, Levine F, Itkin-Ansari P
Mol Cancer Res. 2011
PubMed ID: 21498546
miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1.
Hwang-Verslues WW, Chang PH, Wei PC, Yang CY, Huang CK, Kuo WH, Shew JY, Chang KJ, Lee EY, Lee WH
Oncogene. 2011
PubMed ID: 21258409
Regulation of TCR Vγ2 gene rearrangement by the helix-loop-helix protein, E2A.
Nozaki M, Wakae K, Tamaki N, Sakamoto S, Ohnishi K, Uejima T, Minato N, Yanagihara I, Agata Y
Int Immunol. 2011
PubMed ID: 21421735
Interaction of Hand2 and E2a is important for transcription of Phox2b in sympathetic nervous system neuron differentiation.
Hashimoto Y, Tsutsumi M, Myojin R, Maruta K, Onoda F, Tashiro F, Ohtsu M, Murakami Y
Biochem Biophys Res Commun. 2011
PubMed ID: 21453680
Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2.
Hikasa H, Sokol SY
J Biol Chem. 2011
PubMed ID: 21285352
E47 retroviral rescue of intrinsic B-cell defects in senescent mice.
Landin AM, Frasca D, Harrison P, Scallan M, Riley RL, Blomberg BB
Aging Cell. 2011
PubMed ID: 21241451
E47 regulates hematopoietic stem cell proliferation and energetics but not myeloid lineage restriction.
Yang Q, Esplin B, Borghesi L
Blood. 2011
PubMed ID: 21273306
Claudin-4 induction by E-protein activity in later stages of CD4/8 double-positive thymocytes to increase positive selection efficiency.
Kawai Y, Hamazaki Y, Fujita H, Fujita A, Sato T, Furuse M, Fujimoto T, Jetten AM, Agata Y, Minato N
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21325057
E2A is a transcriptional regulator of CD38 expression in chronic lymphocytic leukemia.
Saborit-Villarroya I, Vaisitti T, Rossi D, D'Arena G, Gaidano G, Malavasi F, Deaglio S
Leukemia. 2011
PubMed ID: 21212793
Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells.
Chen Z, Xiao Y, Zhang J, Li J, Liu Y, Zhao Y, Ma C, Luo J, Qiu Y, Huang G, Korteweg C, Gu J
PLoS One. 2011
PubMed ID: 21655267
Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis.
Lee K, Gjorevski N, Boghaert E, Radisky DC, Nelson CM
EMBO J. 2011
PubMed ID: 21610693
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3.
Maruyama T, Li J, Vaque JP, Konkel JE, Wang W, Zhang B, Zhang P, Zamarron BF, Yu D, Wu Y, Zhuang Y, Gutkind JS, Chen W
Nat Immunol. 2011
PubMed ID: 21131965
Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.
Nie L, Zhao Y, Wu W, Yang YZ, Wang HC, Sun XH
Cell Res. 2010
PubMed ID: 21119685
E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response.
Liu TY, Chen SU, Kuo SH, Cheng AL, Lin CW
Mod Pathol. 2010
PubMed ID: 20802470
Context-dependent regulation of hematopoietic lineage choice by HEBAlt.
Wang D, Claus CL, Rajkumar P, Braunstein M, Moore AJ, Sigvardsson M, Anderson MK
J Immunol. 2010
PubMed ID: 20826759
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Hirose K, Inukai T, Kikuchi J, Furukawa Y, Ikawa T, Kawamoto H, Oram SH, Göttgens B, Kiyokawa N, Miyagawa Y, Okita H, Akahane K, Zhang X, Kuroda I, Honna H, Kagami K, Goi K, Kurosawa H, Look AT, Matsui H, Inaba T, Sugita K
Blood. 2010
PubMed ID: 20519628
TIF1gamma controls erythroid cell fate by regulating transcription elongation.
Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI
Cell. 2010
PubMed ID: 20603019
Genetic evidence that SOST inhibits WNT signaling in the limb.
Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG
Dev Biol. 2010
PubMed ID: 20359476
Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation.
Salomonis N, Schlieve CR, Pereira L, Wahlquist C, Colas A, Zambon AC, Vranizan K, Spindler MJ, Pico AR, Cline MS, Clark TA, Williams A, Blume JE, Samal E, Mercola M, Merrill BJ, Conklin BR
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20498046
Protein phosphatase 2A (PP2A) is increased in old murine B cells and mediates p38 MAPK/tristetraprolin dephosphorylation and E47 mRNA instability.
Frasca D, Romero M, Landin AM, Diaz A, Riley RL, Blomberg BB
Mech Ageing Dev. 2010
PubMed ID: 20219523
Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development.
Holler KL, Hendershot TJ, Troy SE, Vincentz JW, Firulli AB, Howard MJ
Dev Biol. 2010
PubMed ID: 20144608
Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function.
Pan F, Yang TL, Chen XD, Chen Y, Gao G, Liu YZ, Pei YF, Sha BY, Jiang Y, Xu C, Recker RR, Deng HW
Immunogenetics. 2010
PubMed ID: 20217071
Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia.
Yamasaki N, Miyazaki K, Nagamachi A, Koller R, Oda H, Miyazaki M, Sasaki T, Honda ZI, Wolff L, Inaba T, Honda H
Oncogene. 2010
PubMed ID: 20062079
Non-cell-autonomous stimulation of stem cell proliferation following ablation of Tcf3.
Yi F, Merrill BJ
Exp Cell Res. 2010
PubMed ID: 20006604
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells.
D'Cruz LM, Knell J, Fujimoto JK, Goldrath AW
Nat Immunol. 2010
PubMed ID: 20154672
Calmodulin inhibition of E2A stops expression of surrogate light chains of the pre-B-cell receptor and CD19.
Hauser J, Wallenius A, Sveshnikova N, Saarikettu J, Grundström T
Mol Immunol. 2010
PubMed ID: 20022378
Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.
Malin S, McManus S, Cobaleda C, Novatchkova M, Delogu A, Bouillet P, Strasser A, Busslinger M
Nat Immunol. 2010
PubMed ID: 19946273
Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription.
Furumatsu T, Shukunami C, Amemiya-Kudo M, Shimano H, Ozaki T
Int J Biochem Cell Biol. 2010
PubMed ID: 19828133
Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors.
Cai Y, Xu Z, Xie J, Ham AJ, Koury MJ, Hiebert SW, Brandt SJ
Biochem Biophys Res Commun. 2009
PubMed ID: 19799863
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin.
Rittié L, Stoll SW, Kang S, Voorhees JJ, Fisher GJ
Aging Cell. 2009
PubMed ID: 20050020
Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways.
Pedraza N, Rafel M, Navarro I, Encinas M, Aldea M, Gallego C
J Biol Chem. 2009
PubMed ID: 19801649
Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development.
Inlay MA, Bhattacharya D, Sahoo D, Serwold T, Seita J, Karsunky H, Plevritis SK, Dill DL, Weissman IL
Genes Dev. 2009
PubMed ID: 19833765
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
Nishiyama A, Xin L, Sharov AA, Thomas M, Mowrer G, Meyers E, Piao Y, Mehta S, Yee S, Nakatake Y, Stagg C, Sharova L, Correa-Cerro LS, Bassey U, Hoang H, Kim E, Tapnio R, Qian Y, Dudekula D, Zalzman M, Li M, Falco G, Yang HT, Lee SL, Monti M, Stanghellini I, Islam MN, Nagaraja R, Goldberg I, Wang W, Longo DL, Schlessinger D, Ko MS
Cell Stem Cell. 2009
PubMed ID: 19796622
Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.
Mandal M, Powers SE, Ochiai K, Georgopoulos K, Kee BL, Singh H, Clark MR
Nat Immunol. 2009
PubMed ID: 19734904
Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia.
Nguyen H, Merrill BJ, Polak L, Nikolova M, Rendl M, Shaver TM, Pasolli HA, Fuchs E
Nat Genet. 2009
PubMed ID: 19718027
Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci.
Beck K, Peak MM, Ota T, Nemazee D, Murre C
J Exp Med. 2009
PubMed ID: 19752184
High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population.
Mugford JW, Yu J, Kobayashi A, McMahon AP
Dev Biol. 2009
PubMed ID: 19591821
A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.
Fu H, Cai J, Clevers H, Fast E, Gray S, Greenberg R, Jain MK, Ma Q, Qiu M, Rowitch DH, Taylor CM, Stiles CD
J Neurosci. 2009
PubMed ID: 19741146
Promoter activity 5' of Dbeta2 is coordinated by E47, Runx1, and GATA-3.
McMillan RE, Sikes ML
Mol Immunol. 2009
PubMed ID: 19592096
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.
Yashiro-Ohtani Y, He Y, Ohtani T, Jones ME, Shestova O, Xu L, Fang TC, Chiang MY, Intlekofer AM, Blacklow SC, Zhuang Y, Pear WS
Genes Dev. 2009
PubMed ID: 19605688
Initiation of antigen receptor-dependent differentiation into plasma cells by calmodulin inhibition of E2A.
Hauser J, Verma-Gaur J, Wallenius A, Grundström T
J Immunol. 2009
PubMed ID: 19553523
Sequestration of E12/E47 and suppression of p27KIP1 play a role in Id2-induced proliferation and tumorigenesis.
Trabosh VA, Divito KA, D Aguda B, Simbulan-Rosenthal CM, Rosenthal DS
Carcinogenesis. 2009
PubMed ID: 19451188
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis.
Hu X, Li X, Valverde K, Fu X, Noguchi C, Qiu Y, Huang S
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19497860
Synergistic nuclear import of NeuroD1 and its partner transcription factor, E47, via heterodimerization.
Mehmood R, Yasuhara N, Oe S, Nagai M, Yoneda Y
Exp Cell Res. 2009
PubMed ID: 19272376
NK cells in the CD19- B220+ bone marrow fraction are increased in senescence and reduce E2A and surrogate light chain proteins in B cell precursors.
King AM, Keating P, Prabhu A, Blomberg BB, Riley RL
Mech Ageing Dev. 2009
PubMed ID: 19428458
Daxx inhibits muscle differentiation by repressing E2A-mediated transcription.
Gupta A, Hou R, Liu L, Hiroyasu S, Hadix JA, Huggins GS, Sibinga NE
J Cell Biochem. 2009
PubMed ID: 19308989
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
The Spt-Ada-Gcn5-acetyltransferase complex interaction motif of E2a is essential for a subset of transcriptional and oncogenic properties of E2a-Pbx1.
Scheele JS, Kolanczyk M, Gantert M, Zemojtel T, Dorn A, Sykes DP, Möbest DC, Kamps MP, Räpple D, Duchniewicz M
Leuk Lymphoma. 2009
PubMed ID: 19399691
Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis.
Decker T, Pasca di Magliano M, McManus S, Sun Q, Bonifer C, Tagoh H, Busslinger M
Immunity. 2009
PubMed ID: 19345119
Human calcium/calmodulin-dependent serine protein kinase regulates the expression of p21 via the E2A transcription factor.
Sun R, Su Y, Zhao X, Qi J, Luo X, Yang Z, Yao Y, Luo X, Xia Z
Biochem J. 2009
PubMed ID: 19125693
The class I bHLH factors E2-2A and E2-2B regulate EMT.
Sobrado VR, Moreno-Bueno G, Cubillo E, Holt LJ, Nieto MA, Portillo F, Cano A
J Cell Sci. 2009
PubMed ID: 19295128
LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons.
Joshi K, Lee S, Lee B, Lee JW, Lee SK
Neuron. 2009
PubMed ID: 19323994
MyoD and E-protein heterodimers switch rhabdomyosarcoma cells from an arrested myoblast phase to a differentiated state.
Yang Z, MacQuarrie KL, Analau E, Tyler AE, Dilworth FJ, Cao Y, Diede SJ, Tapscott SJ
Genes Dev. 2009
PubMed ID: 19299559
SCL and associated proteins distinguish active from repressive GATA transcription factor complexes.
Tripic T, Deng W, Cheng Y, Zhang Y, Vakoc CR, Gregory GD, Hardison RC, Blobel GA
Blood. 2009
PubMed ID: 19011221
E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors.
Semerad CL, Mercer EM, Inlay MA, Weissman IL, Murre C
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19181846
Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions.
Cochrane SW, Zhao Y, Welner RS, Sun XH
Blood. 2009
PubMed ID: 18927439
Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage.
Thal MA, Carvalho TL, He T, Kim HG, Gao H, Hagman J, Klug CA
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19122139
A tamoxifen inducible knock-in allele for investigation of E2A function.
Jones ME, Kondo M, Zhuang Y
BMC Dev Biol. 2009
PubMed ID: 19822014
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Regulation of the bHLH transcription factor E2A in epithelial cells by interaction with the Na/K-ATPase beta1 subunit.
Plotkin M, Pelger L
Arch Biochem Biophys. 2008
PubMed ID: 18727914
E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.
Yang Q, Kardava L, St Leger A, Martincic K, Varnum-Finney B, Bernstein ID, Milcarek C, Borghesi L
J Immunol. 2008
PubMed ID: 18941177
Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.
Stevens JD, Roalson EH, Skinner MK
Differentiation. 2008
PubMed ID: 18557763
E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene.
Jia J, Dai M, Zhuang Y
Eur J Immunol. 2008
PubMed ID: 18958875
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
BCR-ABL, ETV6-RUNX1 and E2A-PBX1: prevalence of the most common acute lymphoblastic leukemia fusion genes in Mexican patients.
Jiménez-Morales S, Miranda-Peralta E, Saldaña-Alvarez Y, Perez-Vera P, Paredes-Aguilera R, Rivera-Luna R, Velázquez-Cruz R, Ramírez-Bello J, Carnevale A, Orozco L
Leuk Res. 2008
PubMed ID: 18455790
The helix-loop-helix factors Id3 and E47 are novel regulators of adiponectin.
Doran AC, Meller N, Cutchins A, Deliri H, Slayton RP, Oldham SN, Kim JB, Keller SR, McNamara CA
Circ Res. 2008
PubMed ID: 18669923
Stem cell-specific epigenetic priming and B cell-specific transcriptional activation at the mouse Cd19 locus.
Walter K, Bonifer C, Tagoh H
Blood. 2008
PubMed ID: 18552207
Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis.
Kassouf MT, Chagraoui H, Vyas P, Porcher C
Blood. 2008
PubMed ID: 18550854
Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins.
Ji M, Li H, Suh HC, Klarmann KD, Yokota Y, Keller JR
Blood. 2008
PubMed ID: 18523151
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
E2A proteins promote development of lymphoid-primed multipotent progenitors.
Dias S, Månsson R, Gurbuxani S, Sigvardsson M, Kee BL
Immunity. 2008
PubMed ID: 18674933
Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin.
Lavoie PL, Budry L, Balsalobre A, Drouin J
Mol Endocrinol. 2008
PubMed ID: 18388149
Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development.
Kwon K, Hutter C, Sun Q, Bilic I, Cobaleda C, Malin S, Busslinger M
Immunity. 2008
PubMed ID: 18538592
A role for E2-2 at the DN3 stage of early thymopoiesis.
Wikström I, Forssell J, Penha-Goncalves MN, Bergqvist I, Holmberg D
Mol Immunol. 2008
PubMed ID: 18384878
Calcium regulation of myogenesis by differential calmodulin inhibition of basic helix-loop-helix transcription factors.
Hauser J, Saarikettu J, Grundström T
Mol Biol Cell. 2008
PubMed ID: 18353974
E protein dosage influences brain development more than family member identity.
Ravanpay AC, Olson JM
J Neurosci Res. 2008
PubMed ID: 18214987
Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells.
Frasca D, Landin AM, Lechner SC, Ryan JG, Schwartz R, Riley RL, Blomberg BB
J Immunol. 2008
PubMed ID: 18390709
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
E2A-ZNF384 and NOL1-E2A fusion created by a cryptic t(12;19)(p13.3; p13.3) in acute leukemia.
Zhong CH, Prima V, Liang X, Frye C, McGavran L, Meltesen L, Wei Q, Boomer T, Varella-Garcia M, Gump J, Hunger SP
Leukemia. 2008
PubMed ID: 18185522
Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.
Landry JR, Kinston S, Knezevic K, de Bruijn MF, Wilson N, Nottingham WT, Peitz M, Edenhofer F, Pimanda JE, Ottersbach K, Göttgens B
Blood. 2008
PubMed ID: 18184866
Regulation of lymphocyte development by cell-type-specific interpretation of Notch signals.
Nie L, Perry SS, Zhao Y, Huang J, Kincade PW, Farrar MA, Sun XH
Mol Cell Biol. 2008
PubMed ID: 18195039
differential roles for the E2A activation domains in B lymphocytes and macrophages.
Bhalla S, Spaulding C, Brumbaugh RL, Zagort DE, Massari ME, Murre C, Kee BL
J Immunol. 2008
PubMed ID: 18209066
Pod1 induces myofibroblast differentiation in mesenchymal progenitor cells from mouse kidney.
Plotkin M, Mudunuri V
J Cell Biochem. 2008
PubMed ID: 17551956
Crystal structure of E47-NeuroD1/beta2 bHLH domain-DNA complex: heterodimer selectivity and DNA recognition.
Longo A, Guanga GP, Rose RB
Biochemistry. 2008
PubMed ID: 18069799
Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors.
Pla P, Hirsch MR, Le Crom S, Reiprich S, Harley VR, Goridis C
Neural Dev. 2008
PubMed ID: 18565209
Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47.
Agata Y, Tamaki N, Sakamoto S, Ikawa T, Masuda K, Kawamoto H, Murre C
Immunity. 2007
PubMed ID: 18093539
Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors.
Jones ME, Zhuang Y
Immunity. 2007
PubMed ID: 18093538
Regulation of neurogenin stability by ubiquitin-mediated proteolysis.
Vosper JM, Fiore-Heriche CS, Horan I, Wilson K, Wise H, Philpott A
Biochem J. 2007
PubMed ID: 17623011
The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors.
Flora A, Garcia JJ, Thaller C, Zoghbi HY
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17878293
Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities.
Firulli BA, Redick BA, Conway SJ, Firulli AB
J Biol Chem. 2007
PubMed ID: 17652084
YY1 functions with INO80 to activate transcription.
Cai Y, Jin J, Yao T, Gottschalk AJ, Swanson SK, Wu S, Shi Y, Washburn MP, Florens L, Conaway RC, Conaway JW
Nat Struct Mol Biol. 2007
PubMed ID: 17721549
Tristetraprolin, a negative regulator of mRNA stability, is increased in old B cells and is involved in the degradation of E47 mRNA.
Frasca D, Landin AM, Alvarez JP, Blackshear PJ, Riley RL, Blomberg BB
J Immunol. 2007
PubMed ID: 17617583
Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts.
Léjard V, Brideau G, Blais F, Salingcarnboriboon R, Wagner G, Roehrl MH, Noda M, Duprez D, Houillier P, Rossert J
J Biol Chem. 2007
PubMed ID: 17430895
Nine-amino-acid transactivation domain: establishment and prediction utilities.
Piskacek S, Gregor M, Nemethova M, Grabner M, Kovarik P, Piskacek M
Genomics. 2007
PubMed ID: 17467953
Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas.
Xu W, Kee BL
Blood. 2007
PubMed ID: 17272506
Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity.
Boos MD, Yokota Y, Eberl G, Kee BL
J Exp Med. 2007
PubMed ID: 17452521
E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.
Wojciechowski J, Lai A, Kondo M, Zhuang Y
J Immunol. 2007
PubMed ID: 17442955
Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia.
Barber KE, Harrison CJ, Broadfield ZJ, Stewart AR, Wright SL, Martineau M, Strefford JC, Moorman AV
Genes Chromosomes Cancer. 2007
PubMed ID: 17311319
The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytes.
Suleiman H, Heudobler D, Raschta AS, Zhao Y, Zhao Q, Hertting I, Vitzthum H, Moeller MJ, Holzman LB, Rachel R, Johnson R, Westphal H, Rascle A, Witzgall R
Dev Biol. 2007
PubMed ID: 17316599
Accelerated Notch-dependent degradation of E47 proteins in aged B cell precursors is associated with increased ERK MAPK activation.
King AM, Van der Put E, Blomberg BB, Riley RL
J Immunol. 2007
PubMed ID: 17339447
1alpha,25(OH)2D3-induced DNA methylation suppresses the human CYP27B1 gene.
Kim MS, Fujiki R, Kitagawa H, Kato S
Mol Cell Endocrinol. 2007
PubMed ID: 17250953
Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19.
Inukai T, Hirose K, Inaba T, Kurosawa H, Hama A, Inada H, Chin M, Nagatoshi Y, Ohtsuka Y, Oda M, Goto H, Endo M, Morimoto A, Imaizumi M, Kawamura N, Miyajima Y, Ohtake M, Miyaji R, Saito M, Tawa A, Yanai F, Goi K, Nakazawa S, Sugita K
Leukemia. 2007
PubMed ID: 17183364
Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene.
Turunen MM, Dunlop TW, Carlberg C, Väisänen S
Nucleic Acids Res. 2007
PubMed ID: 17426122
Novel binding partners of Ldb1 are required for haematopoietic development.
Meier N, Krpic S, Rodriguez P, Strouboulis J, Monti M, Krijgsveld J, Gering M, Patient R, Hostert A, Grosveld F
Development. 2006
PubMed ID: 17108004
E2-2 regulates the expansion of pro-B cells and follicular versus marginal zone decisions.
Wikström I, Forssell J, Goncalves M, Colucci F, Holmberg D
J Immunol. 2006
PubMed ID: 17082585
ABCB1 over-expression and drug-efflux in acute lymphoblastic leukemia cell lines with t(17;19) and E2A-HLF expression.
Baudis M, Prima V, Tung YH, Hunger SP
Pediatr Blood Cancer. 2006
PubMed ID: 16206189
The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
Science. 2006
PubMed ID: 16959974
Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition.
Moreno-Bueno G, Cubillo E, Sarrió D, Peinado H, Rodríguez-Pinilla SM, Villa S, Bolós V, Jordá M, Fabra A, Portillo F, Palacios J, Cano A
Cancer Res. 2006
PubMed ID: 17018611
A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.
Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA
Development. 2006
PubMed ID: 16971476
E2A promotes the survival of precursor and mature B lymphocytes.
Lazorchak AS, Wojciechowski J, Dai M, Zhuang Y
J Immunol. 2006
PubMed ID: 16888011
Overexpression of E2A proteins induces epithelial-mesenchymal transition in human renal proximal tubular epithelial cells suggesting a potential role in renal fibrosis.
Slattery C, McMorrow T, Ryan MP
FEBS Lett. 2006
PubMed ID: 16814783
Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development.
Schwartz R, Engel I, Fallahi-Sichani M, Petrie HT, Murre C
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16782810
The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line.
Casagrande G, te Kronnie G, Basso G
Haematologica. 2006
PubMed ID: 16769578
Identification of a candidate regulatory element within the 5' flanking region of the mouse Igh locus defined by pro-B cell-specific hypersensitivity associated with binding of PU.1, Pax5, and E2A.
Pawlitzky I, Angeles CV, Siegel AM, Stanton ML, Riblet R, Brodeur PH
J Immunol. 2006
PubMed ID: 16709844
E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells.
Rothschild G, Zhao X, Iavarone A, Lasorella A
Mol Cell Biol. 2006
PubMed ID: 16705184
E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment.
Ikawa T, Kawamoto H, Goldrath AW, Murre C
J Exp Med. 2006
PubMed ID: 16682500
Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms.
Reschly EJ, Spaulding C, Vilimas T, Graham WV, Brumbaugh RL, Aifantis I, Pear WS, Kee BL
Blood. 2006
PubMed ID: 16449526
Cortical thinning and hydrocephalus in mice lacking the immunoglobulin superfamily member CDO.
Zhang W, Yi MJ, Chen X, Cole F, Krauss RS, Kang JS
Mol Cell Biol. 2006
PubMed ID: 16648472
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells.
Lazorchak AS, Schlissel MS, Zhuang Y
Mol Cell Biol. 2006
PubMed ID: 16428437
ETO2 coordinates cellular proliferation and differentiation during erythropoiesis.
Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T
EMBO J. 2006
PubMed ID: 16407974
HIC-5 is a novel repressor of lymphoid enhancer factor/T-cell factor-driven transcription.
Ghogomu SM, van Venrooy S, Ritthaler M, Wedlich D, Gradl D
J Biol Chem. 2006
PubMed ID: 16291758
E47 is required for V(D)J recombinase activity in common lymphoid progenitors.
Borghesi L, Aites J, Nelson S, Lefterov P, James P, Gerstein R
J Exp Med. 2005
PubMed ID: 16365147
Pax1/E2a double-mutant mice develop non-lethal neural tube defects that resemble human malformations.
Joosten PH, van Zoelen EJ, Murre C
Transgenic Res. 2005
PubMed ID: 16315099
A mutually stimulating loop involving emx2 and canonical wnt signalling specifically promotes expansion of occipital cortex and hippocampus.
Muzio L, Soria JM, Pannese M, Piccolo S, Mallamaci A
Cereb Cortex. 2005
PubMed ID: 15800025
Ligand-induced transrepression by VDR through association of WSTF with acetylated histones.
Fujiki R, Kim MS, Sasaki Y, Yoshimura K, Kitagawa H, Kato S
EMBO J. 2005
PubMed ID: 16252006
RNA stability of the E2A-encoded transcription factor E47 is lower in splenic activated B cells from aged mice.
Frasca D, Van der Put E, Landin AM, Gong D, Riley RL, Blomberg BB
J Immunol. 2005
PubMed ID: 16272318
RFP represses transcriptional activation by bHLH transcription factors.
Bloor AJ, Kotsopoulou E, Hayward P, Champion BR, Green AR
Oncogene. 2005
PubMed ID: 16007160
[Detection of fusion genes resulting from chromosome abnormalities in childhood acute lymphoblastic leukemia]
He J, Chen ZX, Xue YQ, Li JQ, He HL, Huang YP, He YX, Chai YH, Zhu LL
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005
PubMed ID: 16215946
Deficient B lymphopoiesis in murine senescence: potential roles for dysregulation of E2A, Pax-5, and STAT5.
Riley RL, Van der Put E, King AM, Frasca D, Blomberg BB
Semin Immunol. 2005
PubMed ID: 15967678
E12 and E47 modulate cellular localization and proteasome-mediated degradation of MyoD and Id1.
Lingbeck JM, Trausch-Azar JS, Ciechanover A, Schwartz AL
Oncogene. 2005
PubMed ID: 16007194
MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters.
Morin S, Pozzulo G, Robitaille L, Cross J, Nemer M
J Biol Chem. 2005
PubMed ID: 16043483
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2.
Nakagawa O, Arnold M, Nakagawa M, Hamada H, Shelton JM, Kusano H, Harris TM, Childs G, Campbell KP, Richardson JA, Nishino I, Olson EN
Genes Dev. 2005
PubMed ID: 16140986
Role of the basic helix-loop-helix transcription factor, scleraxis, in the regulation of Sertoli cell function and differentiation.
Muir T, Sadler-Riggleman I, Skinner MK
Mol Endocrinol. 2005
PubMed ID: 15831523
The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1.
Hetfeld BK, Helfrich A, Kapelari B, Scheel H, Hofmann K, Guterman A, Glickman M, Schade R, Kloetzel PM, Dubiel W
Curr Biol. 2005
PubMed ID: 16005295
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS
J Cell Sci. 2005
PubMed ID: 15923648
Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Taniwaki T, Haruna K, Nakamura H, Sekimoto T, Oike Y, Imaizumi T, Saito F, Muta M, Soejima Y, Utoh A, Nakagata N, Araki M, Yamamura K, Araki K
Dev Growth Differ. 2005
PubMed ID: 15840001
E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription.
Lluís F, Ballestar E, Suelves M, Esteller M, Muñoz-Cánoves P
EMBO J. 2005
PubMed ID: 15719023
Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells.
Lee SK, Lee B, Ruiz EC, Pfaff SL
Genes Dev. 2005
PubMed ID: 15655114
E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells.
Bayly R, Chuen L, Currie RA, Hyndman BD, Casselman R, Blobel GA, LeBrun DP
J Biol Chem. 2004
PubMed ID: 15507449
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
Snail regulates p21(WAF/CIP1) expression in cooperation with E2A and Twist.
Takahashi E, Funato N, Higashihori N, Hata Y, Gridley T, Nakamura M
Biochem Biophys Res Commun. 2004
PubMed ID: 15555546
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO.
Cole F, Zhang W, Geyra A, Kang JS, Krauss RS
Dev Cell. 2004
PubMed ID: 15572127
Netrins and neogenin promote myotube formation.
Kang JS, Yi MJ, Zhang W, Feinleib JL, Cole F, Krauss RS
J Cell Biol. 2004
PubMed ID: 15520228
Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2.
Hill AA, Riley PR
Mol Cell Biol. 2004
PubMed ID: 15509787
E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII).
van der Stoep N, Quinten E, Marcondes Rezende M, van den Elsen PJ
Blood. 2004
PubMed ID: 15242870
Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1.
Viñals F, Ventura F
J Biol Chem. 2004
PubMed ID: 15322112
Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes.
Greenbaum S, Lazorchak AS, Zhuang Y
J Biol Chem. 2004
PubMed ID: 15310760
Differential cooperation between dHAND and three different E-proteins.
Murakami M, Kataoka K, Tominaga J, Nakagawa O, Kurihara H
Biochem Biophys Res Commun. 2004
PubMed ID: 15351717
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination.
Huang Z, Nie L, Xu M, Sun XH
Mol Cell Biol. 2004
PubMed ID: 15456869
Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription.
Maier H, Ostraat R, Gao H, Fields S, Shinton SA, Medina KL, Ikawa T, Murre C, Singh H, Hardy RR, Hagman J
Nat Immunol. 2004
PubMed ID: 15361869
Calcium/calmodulin inhibition of transcriptional activity of E-proteins by prevention of their binding to DNA.
Saarikettu J, Sveshnikova N, Grundström T
J Biol Chem. 2004
PubMed ID: 15280352
Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.
Schlaeger TM, Schuh A, Flitter S, Fisher A, Mikkola H, Orkin SH, Vyas P, Porcher C
Mol Cell Biol. 2004
PubMed ID: 15314159
Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation.
Samanta J, Kessler JA
Development. 2004
PubMed ID: 15280210
Genomic analysis of mouse retinal development.
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
PLoS Biol. 2004
PubMed ID: 15226823
E protein silencing by the leukemogenic AML1-ETO fusion protein.
Zhang J, Kalkum M, Yamamura S, Chait BT, Roeder RG
Science. 2004
PubMed ID: 15333839
Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function.
Xing Y, Clements WK, Le Trong I, Hinds TR, Stenkamp R, Kimelman D, Xu W
Mol Cell. 2004
PubMed ID: 15327769
MEKK1 signaling through p38 leads to transcriptional inactivation of E47 and repression of skeletal myogenesis.
Page JL, Wang X, Sordillo LM, Johnson SE
J Biol Chem. 2004
PubMed ID: 15159407
Regulation of cellular senescence and p16(INK4a) expression by Id1 and E47 proteins in human diploid fibroblast.
Zheng W, Wang H, Xue L, Zhang Z, Tong T
J Biol Chem. 2004
PubMed ID: 15138269
Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A.
Seet CS, Brumbaugh RL, Kee BL
J Exp Med. 2004
PubMed ID: 15210745
TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.
O'Neil J, Shank J, Cusson N, Murre C, Kelliher M
Cancer Cell. 2004
PubMed ID: 15193261
Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary.
Bayne RA, Martins da Silva SJ, Anderson RA
Mol Hum Reprod. 2004
PubMed ID: 15044608
E2A/HEB and Id3 proteins control the sensitivity to glucocorticoid-induced apoptosis in thymocytes by regulating the SRG3 expression.
Ko M, Ahn J, Lee C, Chung H, Jeon SH, Chung HY, Seong RH
J Biol Chem. 2004
PubMed ID: 15016815
Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A.
Quong MW, Martensson A, Langerak AW, Rivera RR, Nemazee D, Murre C
J Exp Med. 2004
PubMed ID: 15078898
Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein.
Matsunaga T, Inaba T, Matsui H, Okuya M, Miyajima A, Inukai T, Funabiki T, Endo M, Look AT, Kurosawa H
Blood. 2004
PubMed ID: 15070701
Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching.
Murayama A, Kim MS, Yanagisawa J, Takeyama K, Kato S
EMBO J. 2004
PubMed ID: 15934135
The DNA sequence and biology of human chromosome 19.
Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM
Nature. 2004
PubMed ID: 15057824
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Regulation of E2A gene expression in B-lymphocyte development.
Zhuang Y, Jackson A, Pan L, Shen K, Dai M
Mol Immunol. 2004
PubMed ID: 15104122
Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent.
Ikawa T, Kawamoto H, Wright LY, Murre C
Immunity. 2004
PubMed ID: 15030778
Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase.
Frasca D, Van der Put E, Riley RL, Blomberg BB
J Immunol. 2004
PubMed ID: 14764681
Effects of aging on DNA-binding activity of the E47 transcription factor in splenic B cells.
Frasca D, Nguyen D, Riley RL, Blomberg BB
Mech Ageing Dev. 2004
PubMed ID: 15037012
Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes.
Pan L, Bradney C, Zheng B, Zhuang Y
Immunology. 2004
PubMed ID: 15027899
Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.
Gazit R, Krizhanovsky V, Ben-Arie N
Development. 2004
PubMed ID: 14757642
Genomic organization and characterization of the promoter for the E2A gene.
Hata K, Mizuguchi J
Gene. 2004
PubMed ID: 14697510
E2A proteins enforce a proliferation checkpoint in developing thymocytes.
Engel I, Murre C
EMBO J. 2004
PubMed ID: 14685278
Synergistic activation of the human orphan nuclear receptor SHP gene promoter by basic helix-loop-helix protein E2A and orphan nuclear receptor SF-1.
Kim HJ, Kim JY, Park YY, Choi HS
Nucleic Acids Res. 2003
PubMed ID: 14627819
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities.
Nie L, Xu M, Vladimirova A, Sun XH
EMBO J. 2003
PubMed ID: 14592976
Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex.
Sun T, Dong H, Wu L, Kane M, Rowitch DH, Stiles CD
J Neurosci. 2003
PubMed ID: 14573534
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
The LIM-only protein LMO4 modulates the transcriptional activity of HEN1.
Manetopoulos C, Hansson A, Karlsson J, Jönsson JI, Axelson H
Biochem Biophys Res Commun. 2003
PubMed ID: 12878195
Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1.
Smith KS, Chanda SK, Lingbeek M, Ross DT, Botstein D, van Lohuizen M, Cleary ML
Mol Cell. 2003
PubMed ID: 14536079
E-proteins directly regulate expression of activation-induced deaminase in mature B cells.
Sayegh CE, Quong MW, Agata Y, Murre C
Nat Immunol. 2003
PubMed ID: 12717431
The age-related decrease in E47 DNA-binding does not depend on increased Id inhibitory proteins in bone marrow-derived B cell precursors.
Frasca D, Nguyen D, Van der Put E, Riley RL, Blomberg BB
Front Biosci. 2003
PubMed ID: 12700059
E2A basic helix-loop-helix transcription factors in human leukemia.
LeBrun DP
Front Biosci. 2003
PubMed ID: 12700034
Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL.
Tremblay M, Herblot S, Lecuyer E, Hoang T
J Biol Chem. 2003
PubMed ID: 12566462
Effects of aging on proliferation and E47 transcription factor activity induced by different stimuli in murine splenic B cells.
Frasca D, Nguyen D, Riley RL, Blomberg BB
Mech Ageing Dev. 2003
PubMed ID: 12714241
Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 suppresses differentiation by negative regulation of transcription.
Funato N, Ohyama K, Kuroda T, Nakamura M
J Biol Chem. 2003
PubMed ID: 12493738
Regulation of E2A activities by histone acetyltransferases in B lymphocyte development.
Bradney C, Hjelmeland M, Komatsu Y, Yoshida M, Yao TP, Zhuang Y
J Biol Chem. 2003
PubMed ID: 12435739
Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice.
Frasca D, Nguyen D, Riley RL, Blomberg BB
J Immunol. 2003
PubMed ID: 12517933
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Levels of E2A protein expression in B cell precursors are stage-dependent and inhibited by stem cell factor (c-kit ligand).
Riley RL, Knowles J, King AM
Exp Hematol. 2002
PubMed ID: 12482503
Stra13 homodimers repress transcription through class B E-box elements.
St-Pierre B, Flock G, Zacksenhaus E, Egan SE
J Biol Chem. 2002
PubMed ID: 12297495
Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system.
Greenbaum S, Zhuang Y
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12415115
Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain.
Heng JI, Tan SS
J Biol Chem. 2002
PubMed ID: 12200424
Transformation of bone marrow B-cell progenitors by E2a-Hlf requires coexpression of Bcl-2.
Smith KS, Rhee JW, Cleary ML
Mol Cell Biol. 2002
PubMed ID: 12370314
N-twist, an evolutionarily conserved bHLH protein expressed in the developing CNS, functions as a transcriptional inhibitor.
Verzi MP, Anderson JP, Dodou E, Kelly KK, Greene SB, North BJ, Cripps RM, Black BL
Dev Biol. 2002
PubMed ID: 12217327
Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice.
Engel I, Murre C
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12172006
Aberrant localization of beta-catenin correlates with overexpression of its target gene in human papillary thyroid cancer.
Ishigaki K, Namba H, Nakashima M, Nakayama T, Mitsutake N, Hayashi T, Maeda S, Ichinose M, Kanematsu T, Yamashita S
J Clin Endocrinol Metab. 2002
PubMed ID: 12107263
Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding.
McFadden DG, McAnally J, Richardson JA, Charité J, Olson EN
Development. 2002
PubMed ID: 12070084
Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants.
Wistow G, Bernstein SL, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K
Mol Vis. 2002
PubMed ID: 12107413
The human V-preB promoter is a target for coordinated activation by early B cell factor and E47.
Gisler R, Sigvardsson M
J Immunol. 2002
PubMed ID: 11994467
Notch signaling induces rapid degradation of achaete-scute homolog 1.
Sriuranpong V, Borges MW, Strock CL, Nakakura EK, Watkins DN, Blaumueller CM, Nelkin BD, Ball DW
Mol Cell Biol. 2002
PubMed ID: 11940670
An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus.
Pan L, Hanrahan J, Li J, Hale LP, Zhuang Y
J Immunol. 2002
PubMed ID: 11937548
The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer.
Dai YS, Cserjesi P
J Biol Chem. 2002
PubMed ID: 11812799
The basic helix-loop-helix domain of the E47 transcription factor requires other protein regions for full DNA binding activity.
Lu J, Sloan SR
Biochem Biophys Res Commun. 2002
PubMed ID: 11820794
PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors.
DeKoter RP, Lee HJ, Singh H
Immunity. 2002
PubMed ID: 11869689
Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains.
Knöfler M, Meinhardt G, Bauer S, Loregger T, Vasicek R, Bloor DJ, Kimber SJ, Husslein P
Biochem J. 2002
PubMed ID: 11802795
IL-7Ralpha and E47: independent pathways required for development of multipotent lymphoid progenitors.
Kee BL, Bain G, Murre C
EMBO J. 2002
PubMed ID: 11782430
Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice.
Yoshida S, Ohbo K, Takakura A, Takebayashi H, Okada T, Abe K, Nabeshima Y
Dev Biol. 2001
PubMed ID: 11784080
Protein-protein interaction panel using mouse full-length cDNAs.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y
Genome Res. 2001
PubMed ID: 11591653
Promotion of cell cycle progression by basic helix-loop-helix E2A.
Zhao F, Vilardi A, Neely RJ, Choi JK
Mol Cell Biol. 2001
PubMed ID: 11509675
Role of the transcriptional coactivator CBP/p300 in linking basic helix-loop-helix and CREB responses for follicle-stimulating hormone-mediated activation of the transferrin promoter in Sertoli cells.
Chaudhary J, Skinner MK
Biol Reprod. 2001
PubMed ID: 11466227
A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions.
Perez-Moreno MA, Locascio A, Rodrigo I, Dhondt G, Portillo F, Nieto MA, Cano A
J Biol Chem. 2001
PubMed ID: 11309385
A two-hybrid system for transactivator bait proteins.
Hirst M, Ho C, Sabourin L, Rudnicki M, Penn L, Sadowski I
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11447261
The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice.
O'Neil J, Billa M, Oikemus S, Kelliher M
Oncogene. 2001
PubMed ID: 11439353
Molecular evolution of Sry and Sox gene.
Nagai K
Gene. 2001
PubMed ID: 11404013
p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos.
Obata J, Yano M, Mimura H, Goto T, Nakayama R, Mibu Y, Oka C, Kawaichi M
Genes Cells. 2001
PubMed ID: 11318877
Inhibition of Tcf3 binding by I-mfa domain proteins.
Snider L, Thirlwell H, Miller JR, Moon RT, Groudine M, Tapscott SJ
Mol Cell Biol. 2001
PubMed ID: 11238923
The leukemogenic transcription factor E2a-Pbx1 induces expression of the putative N-myc and p53 target gene NDRG1 in Ba/F3 cells.
Rutherford MN, Bayly GR, Matthews BP, Okuda T, Dinjens WM, Kondoh H, LeBrun DP
Leukemia. 2001
PubMed ID: 11237058
Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-beta.
Kee BL, Rivera RR, Murre C
Nat Immunol. 2001
PubMed ID: 11224524
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function.
Firulli BA, Hadzic DB, McDaid JR, Firulli AB
J Biol Chem. 2000
PubMed ID: 10924525
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints.
Puttagunta R, Gordon LA, Meyer GE, Kapfhamer D, Lamerdin JE, Kantheti P, Portman KM, Chung WK, Jenne DE, Olsen AS, Burmeister M
Genome Res. 2000
PubMed ID: 10984455
A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice.
Feldman BJ, Hampton T, Cleary ML
Blood. 2000
PubMed ID: 10961893
Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB.
Barndt RJ, Dai M, Zhuang Y
Mol Cell Biol. 2000
PubMed ID: 10958665
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Human homologue of maid: A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression.
Terai S, Aoki H, Ashida K, Thorgeirsson SS
Hepatology. 2000
PubMed ID: 10915743
Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity.
Neufeld B, Grosse-Wilde A, Hoffmeyer A, Jordan BW, Chen P, Dinev D, Ludwig S, Rapp UR
J Biol Chem. 2000
PubMed ID: 10781029
A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts.
Vitelli L, Condorelli G, Lulli V, Hoang T, Luchetti L, Croce CM, Peschle C
Mol Cell Biol. 2000
PubMed ID: 10866689
A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors.
Onions J, Hermann S, Grundström T
Biochemistry. 2000
PubMed ID: 10757985
Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location.
El Ghouzzi V, Legeai-Mallet L, Aresta S, Benoist C, Munnich A, de Gunzburg J, Bonaventure J
Hum Mol Genet. 2000
PubMed ID: 10749989
Role of the basic helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells.
Adell T, Gómez-Cuadrado A, Skoudy A, Pettengill OS, Longnecker DS, Real FX
Cell Growth Differ. 2000
PubMed ID: 10768861
Regulation of scleraxis function by interaction with the bHLH protein E47.
Carlberg AL, Tuan RS, Hall DJ
Mol Cell Biol Res Commun. 2000
PubMed ID: 10775504
Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47.
Bain G, Quong MW, Soloff RS, Hedrick SM, Murre C
J Exp Med. 1999
PubMed ID: 10587351
Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain.
Law SF, Zhang YZ, Fashena SJ, Toby G, Estojak J, Golemis EA
Exp Cell Res. 1999
PubMed ID: 10502414
Characterization of the mUBC9-binding sites required for E2A protein degradation.
Huggins GS, Chin MT, Sibinga NE, Lee SL, Haber E, Lee ME
J Biol Chem. 1999
PubMed ID: 10497239
A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1.
Knoepfler PS, Bergstrom DA, Uetsuki T, Dac-Korytko I, Sun YH, Wright WE, Tapscott SJ, Kamps MP
Nucleic Acids Res. 1999
PubMed ID: 10471746
The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cells.
Thorsteinsdottir U, Krosl J, Kroon E, Haman A, Hoang T, Sauvageau G
Mol Cell Biol. 1999
PubMed ID: 10454582
Exchangeable gene trap using the Cre/mutated lox system.
Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki M, Miura K, Araki M, Yamamura K
Cell Mol Biol (Noisy-le-grand). 1999
PubMed ID: 10512203
Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A.
O'Riordan M, Grosschedl R
Immunity. 1999
PubMed ID: 10435576
Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice.
Chervinsky DS, Zhao XF, Lam DH, Ellsworth M, Gross KW, Aplan PD
Mol Cell Biol. 1999
PubMed ID: 10373552
Disrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic mice.
Smith KS, Rhee JW, Naumovski L, Cleary ML
Mol Cell Biol. 1999
PubMed ID: 10330184
Identification of a novel molecular partner of the E2A gene in childhood leukemia.
Brambillasca F, Mosna G, Colombo M, Rivolta A, Caslini C, Minuzzo M, Giudici G, Mizzi L, Biondi A, Privitera E
Leukemia. 1999
PubMed ID: 10086727
Positive and negative regulation of V(D)J recombination by the E2A proteins.
Bain G, Romanow WJ, Albers K, Havran WL, Murre C
J Exp Med. 1999
PubMed ID: 9892611
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF.
Inukai T, Inaba T, Ikushima S, Look AT
Mol Cell Biol. 1998
PubMed ID: 9742120
The transition to endoreduplication in trophoblast giant cells is regulated by the mSNA zinc finger transcription factor.
Nakayama H, Scott IC, Cross JC
Dev Biol. 1998
PubMed ID: 9676199
Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation.
Layne MD, Endege WO, Jain MK, Yet SF, Hsieh CM, Chin MT, Perrella MA, Blanar MA, Haber E, Lee ME
J Biol Chem. 1998
PubMed ID: 9624159
Functional replacement of the mouse E2A gene with a human HEB cDNA.
Zhuang Y, Barndt RJ, Pan L, Kelley R, Dai M
Mol Cell Biol. 1998
PubMed ID: 9584174
Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes.
Massari ME, Rivera RR, Voland JR, Quong MW, Breit TM, van Dongen JJ, de Smit O, Murre C
Mol Cell Biol. 1998
PubMed ID: 9584154
A conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1.
Green NC, Rambaldi I, Teakles J, Featherstone MS
J Biol Chem. 1998
PubMed ID: 9582372
Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells.
Deed RW, Jasiok M, Norton JD
J Biol Chem. 1998
PubMed ID: 9525934
Capsulin: a novel bHLH transcription factor expressed in epicardial progenitors and mesenchyme of visceral organs.
Lu J, Richardson JA, Olson EN
Mech Dev. 1998
PubMed ID: 9545521
The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition.
Park ST, Sun XH
J Biol Chem. 1998
PubMed ID: 9507011
Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2.
Black BL, Molkentin JD, Olson EN
Mol Cell Biol. 1998
PubMed ID: 9418854
High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice.
Yan W, Young AZ, Soares VC, Kelley R, Benezra R, Zhuang Y
Mol Cell Biol. 1997
PubMed ID: 9372963
The mUBC9 murine ubiquitin conjugating enzyme interacts with the E2A transcription factors.
Loveys DA, Streiff MB, Schaefer TS, Kato GJ
Gene. 1997
PubMed ID: 9409784
The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist.
Hamamori Y, Wu HY, Sartorelli V, Kedes L
Mol Cell Biol. 1997
PubMed ID: 9343420
Differential interactions of Id proteins with basic-helix-loop-helix transcription factors.
Langlands K, Yin X, Anand G, Prochownik EV
J Biol Chem. 1997
PubMed ID: 9242638
Novel regulation of the helix-loop-helix protein Id1 by S5a, a subunit of the 26 S proteasome.
Anand G, Yin X, Shahidi AK, Grove L, Prochownik EV
J Biol Chem. 1997
PubMed ID: 9235903
E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas.
Bain G, Engel I, Robanus Maandag EC, te Riele HP, Voland JR, Sharp LL, Chun J, Huey B, Pinkel D, Murre C
Mol Cell Biol. 1997
PubMed ID: 9234734
Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity.
Johnson JD, Zhang W, Rudnick A, Rutter WJ, German MS
Mol Cell Biol. 1997
PubMed ID: 9199284
MyoD-E12 heterodimers and MyoD-MyoD homodimers are equally stable.
Maleki SJ, Royer CA, Hurlburt BK
Biochemistry. 1997
PubMed ID: 9184158
The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins.
Wadman IA, Osada H, Grütz GG, Agulnick AD, Westphal H, Forster A, Rabbitts TH
EMBO J. 1997
PubMed ID: 9214632
LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1.
Osada H, Grutz GG, Axelson H, Forster A, Rabbitts TH
Leukemia. 1997
PubMed ID: 9209374
Identification of interaction partners for the basic-helix-loop-helix protein E47.
Dear TN, Hainzl T, Follo M, Nehls M, Wilmore H, Matena K, Boehm T
Oncogene. 1997
PubMed ID: 9050988
Degradation of E2A proteins through a ubiquitin-conjugating enzyme, UbcE2A.
Kho CJ, Huggins GS, Endege WO, Hsieh CM, Lee ME, Haber E
J Biol Chem. 1997
PubMed ID: 9013644
Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern.
Lemercier C, To RQ, Swanson BJ, Lyons GE, Konieczny SF
Dev Biol. 1997
PubMed ID: 9073453
Both E12 and E47 allow commitment to the B cell lineage.
Bain G, Robanus Maandag EC, te Riele HP, Feeney AJ, Sheehy A, Schlissel M, Shinton SA, Hardy RR, Murre C
Immunity. 1997
PubMed ID: 9047236
Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins.
Lenormand JL, Benayoun B, Guillier M, Vandromme M, Leibovitch MP, Leibovitch SA
Mol Cell Biol. 1997
PubMed ID: 9001211
Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression.
Chen B, Lim RW
J Biol Chem. 1997
PubMed ID: 8999959
Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors.
Gradwohl G, Fode C, Guillemot F
Dev Biol. 1996
PubMed ID: 8948587
Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif.
Maira SM, Wurtz JM, Wasylyk B
EMBO J. 1996
PubMed ID: 8918463
Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family.
Black BL, Ligon KL, Zhang Y, Olson EN
J Biol Chem. 1996
PubMed ID: 8900141
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation.
Hofmann TJ, Cole MD
Oncogene. 1996
PubMed ID: 8760303
E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein.
Loveys DA, Streiff MB, Kato GJ
Nucleic Acids Res. 1996
PubMed ID: 8759016
B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.
Zhuang Y, Cheng P, Weintraub H
Mol Cell Biol. 1996
PubMed ID: 8649400
Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells.
Miyamoto A, Cui X, Naumovski L, Cleary ML
Mol Cell Biol. 1996
PubMed ID: 8628307
Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins.
Groisman R, Masutani H, Leibovitch MP, Robin P, Soudant I, Trouche D, Harel-Bellan A
J Biol Chem. 1996
PubMed ID: 8617811
Polymorphism of the mouse E2A gene due to an intronic deletion of 536 bp.
Marlow SA, Kay PH, Papadimitriou JM
Gene. 1996
PubMed ID: 8654934
Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis.
Li L, Cserjesi P, Olson EN
Dev Biol. 1995
PubMed ID: 7589808
Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1.
Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7568177
The ski/sno protooncogene family in hematopoietic development.
Pearson-White S, Deacon D, Crittenden R, Brady G, Iscove N, Quesenberry PJ
Blood. 1995
PubMed ID: 7662963
B-cell-specific DNA binding by an E47 homodimer.
Shen CP, Kadesch T
Mol Cell Biol. 1995
PubMed ID: 7623842
Failure of B-cell differentiation in mice lacking the transcription factor EBF.
Lin H, Grosschedl R
Nature. 1995
PubMed ID: 7542362
A novel initiator regulates expression of the nontissue-specific helix-loop-helix gene ME1.
Shain DH, Neuman T, Zuber MX
Nucleic Acids Res. 1995
PubMed ID: 7784173
E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements.
Bain G, Maandag EC, Izon DJ, Amsen D, Kruisbeek AM, Weintraub BC, Krop I, Schlissel MS, Feeney AJ, van Roon M
Cell. 1994
PubMed ID: 8001125
The helix-loop-helix gene E2A is required for B cell formation.
Zhuang Y, Soriano P, Weintraub H
Cell. 1994
PubMed ID: 8001124
Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function.
Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB
J Virol. 1994
PubMed ID: 7933101
DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein.
Inaba T, Shapiro LH, Funabiki T, Sinclair AE, Jones BG, Ashmun RA, Look AT
Mol Cell Biol. 1994
PubMed ID: 8164688
Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity.
Xia Y, Hwang LY, Cobb MH, Baer R
Oncogene. 1994
PubMed ID: 8152805
Polymorphism of the mouse transcription factor-encoding gene E2A.
Marlow SA, Kay PH, Papadimitriou JM
Gene. 1994
PubMed ID: 8163208
Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells.
Hsu HL, Wadman I, Baer R
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8159721
Identification of amino-acid polymorphism within the leucine zipper motif of mouse transcription factor A1.
Kajimoto Y, Kawamori R, Umayahara Y, Watada H, Iwama N, Morishima T, Yamasaki Y, Kamada T
Gene. 1994
PubMed ID: 8112613
A genetic linkage map of the mouse: current applications and future prospects.
Copeland NG, Jenkins NA, Gilbert DJ, Eppig JT, Maltais LJ, Miller JC, Dietrich WF, Weaver A, Lincoln SE, Steen RG
Science. 1993
PubMed ID: 8211130
Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice.
Dedera DA, Waller EK, LeBrun DP, Sen-Majumdar A, Stevens ME, Barsh GS, Cleary ML
Cell. 1993
PubMed ID: 8104101
Proposed structure for the DNA-binding domain of the helix-loop-helix family of eukaryotic gene regulatory proteins.
Gibson TJ, Thompson JD, Abagyan RA
Protein Eng. 1993
PubMed ID: 8433970
Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.
Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A
Genomics. 1993
PubMed ID: 8432525
Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis.
Zhuang Y, Kim CG, Bartelmez S, Cheng P, Groudine M, Weintraub H
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1465450
Analysis of the oligomerization of myogenin and E2A products in vivo using a two-hybrid assay system.
Chakraborty T, Martin JF, Olson EN
J Biol Chem. 1992
PubMed ID: 1325437
Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloning.
Nielsen AL, Pallisgaard N, Pedersen FS, Jørgensen P
Mol Cell Biol. 1992
PubMed ID: 1321336
Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia.
Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT
Science. 1992
PubMed ID: 1386162
The nucleotide sequence of the human transcription factor HTF4a cDNA.
Zhang Y, Bina M
DNA Seq. 1992
PubMed ID: 1446075
The helix-loop-helix protein rE12 and the C/EBP-related factor rNFIL-6 bind to neighboring sites within the c-fos serum response element.
Metz R, Ziff E
Oncogene. 1991
PubMed ID: 1766666
Nuclear targeting of the transcription factor PTF1 is mediated by a protein subunit that does not bind to the PTF1 cognate sequence.
Sommer L, Hagenbüchle O, Wellauer PK, Strubin M
Cell. 1991
PubMed ID: 1720355
Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo.
Lassar AB, Davis RL, Wright WE, Kadesch T, Murre C, Voronova A, Baltimore D, Weintraub H
Cell. 1991
PubMed ID: 1649701
The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias.
Hunger SP, Galili N, Carroll AJ, Crist WM, Link MP, Cleary ML
Blood. 1991
PubMed ID: 1671560
Sequence of a HeLa cDNA provides the DNA binding domain and carboxy terminus of HE47: a human helix-loop-helix protein related to the enhancer binding factor E47.
Zhang Y, Bina M
DNA Seq. 1991
PubMed ID: 1818757
Transcriptional activation domain of the muscle-specific gene-regulatory protein myf5.
Braun T, Winter B, Bober E, Arnold HH
Nature. 1990
PubMed ID: 2385294
A congenic line of the BALB/c mouse strain with the endogenous mouse mammary tumor virus proviral gene Mtv-3: tissue-specific expression and correlation with resistance to mouse mammary tumor virus infection and tumorigenesis.
Hainaut P, Castellazzi M, Gonzales D, Clausse N, Hilgers J, Crépin M
Cancer Res. 1990
PubMed ID: 2160325
Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs.
Nelson C, Shen LP, Meister A, Fodor E, Rutter WJ
Genes Dev. 1990
PubMed ID: 2200736
Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains.
Voronova A, Baltimore D
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2112746
Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization.
Brennan TJ, Olson EN
Genes Dev. 1990
PubMed ID: 2163343
A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.
Kamps MP, Murre C, Sun XH, Baltimore D
Cell. 1990
PubMed ID: 1967983
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.
Nourse J, Mellentin JD, Galili N, Wilkinson J, Stanbridge E, Smith SD, Cleary ML
Cell. 1990
PubMed ID: 1967982
Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor.
Henthorn P, McCarrick-Walmsley R, Kadesch T
Nucleic Acids Res. 1990
PubMed ID: 2308859
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif.
Henthorn P, Kiledjian M, Kadesch T
Science. 1990
PubMed ID: 2105528
The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias.
Mellentin JD, Murre C, Donlon TA, McCaw PS, Smith SD, Carroll AJ, McDonald ME, Baltimore D, Cleary ML
Science. 1989
PubMed ID: 2799390
Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence.
Murre C, McCaw PS, Vaessin H, Caudy M, Jan LY, Jan YN, Cabrera CV, Buskin JN, Hauschka SD, Lassar AB
Cell. 1989
PubMed ID: 2503252
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins.
Murre C, McCaw PS, Baltimore D
Cell. 1989
PubMed ID: 2493990

Model Organism Phenotype Links from MGI Top Help

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	Human	Mouse	Rat
Entrez Gene	6929	21423	171046
EnsEMBL Gene(s)	ENSG00000071564	ENSMUSG00000020167	ENSRNOG00000016970
Unigene	Hs.371282	Mm.3406	Rn.10290
Homologene	TCF3	Tcf3	Tcfe2a
OMIM	147141	N/A	N/A
GeneCards	TCF3	N/A	N/A
Beta Cell Genomics	DT.100867319 DT.119679 DT.40133480 DT.454302 DT.92019877 DT.95150823	DT.101160919 DT.101166896 DT.492901 DT.97343385	N/A
Reactome	P15923	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	6929	21423	171046

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Interactor	Interactor	Sources	Classification	Pubmed IDs
TCF3	OLIG2	IntAct	empirical	15280210
TCF3	RUVBL2	IntAct	empirical	16230350
TCF3	OLIG1	IntAct	empirical	15280210
TCF3	CREBBP	HPRD, BioGRID	empirical	12435739 15507449
TCF3	CTNNB1	HPRD	empirical	12107263 15327769
TCF3	DAXX	BioGRID	empirical	19308989
TCF3	AEBP1	HPRD	empirical	9624159
TCF3	BHLHA15	HPRD	empirical	9073453
TCF3	DNMT1	BioGRID	empirical	17250953
TCF3	ELK3	HPRD, BioGRID	empirical	8918463
TCF3	EP300	HPRD, BioGRID	empirical	12435739 15934135
TCF3	FERD3L	HPRD	empirical	12217327
TCF3	PHLDA1	IntAct	empirical	11591653
TCF3	CCNDBP1	IntAct	empirical	10915743
TCF3	RALGAPA1	HPRD	empirical	12200424
TCF3	SIN3A	BioGRID	empirical	16252006 15934135
TCF3	GATA1	IntAct	empirical	7568177
TCF3	GATA2	IntAct	empirical	7568177
TCF3	INO80E	BioGRID	empirical	17721549
TCF3	TFPT	HPRD	empirical	10086727
TCF3	HDAC2	BioGRID	empirical	16252006 15934135 17250953
TCF3	HOXA1	HPRD	empirical	9582372
TCF3	ID1	HPRD, MINT, IntAct, BioGRID	empirical	11591653 10915743 9242638 19125693
TCF3	ID2	HPRD, MINT, IntAct, BioGRID	empirical	11591653 9242638 10915743
TCF3	ID3	HPRD, IntAct, MIPS, BioGRID	empirical	8759016 9525934 10915743 10567574 9242638
TCF3	PDX1	HPRD	empirical	10636926
TCF3	LMO2	IntAct	empirical	7568177
TCF3	LMX1A	BioGRID	empirical	9199284
TCF3	LMX1B	HPRD	empirical	9199284
TCF3	LYL1	HPRD, BioGRID	empirical	8628307
TCF3	MDFI	HPRD	empirical	11238923
TCF3	ASCL1	IntAct	empirical	10903890
TCF3	MYF5	HPRD, BioGRID, Reactome	empirical	2385294 9242638
TCF3	MYF6	BioGRID, Reactome	empirical	9242638
TCF3	MYOD1	HPRD, IntAct, BioGRID, Reactome	empirical	9001211 9184158 1649701 10915743 9242638
TCF3	MYOG	HPRD, BioGRID, Reactome	empirical	1325437 2163343 9242638
TCF3	NEDD9	HPRD	empirical	10502414
TCF3	NHLH1	BioGRID	empirical	12878195
TCF3	TRIM33	BioGRID	empirical	20603019
TCF3	ASB2	BioGRID	empirical	21119685
TCF3	SERPINA1	IntAct	empirical	10915743
TCF3	PRKACA	BioGRID	empirical	15934135
TCF3	MAPK1	HPRD	empirical	14592976
TCF3	MAPK3	HPRD	empirical	14592976
TCF3	ASCL3	HPRD	empirical	11784080
TCF3	PSMD4	HPRD	empirical	9235903
TCF3	PSMD9	HPRD, MIPS	empirical	10567574
TCF3	RB1	BioGRID	empirical	10866689
TCF3	RPL37	IntAct	empirical	21988832
TCF3	SKP2	HPRD, BioGRID	empirical	14592976
TCF3	SMARCA4	BioGRID	empirical	16252006
TCF3	SOX2	BioGRID	empirical	21532573
TCF3	SRF	HPRD	empirical	8617811
TCF3	TAL1	HPRD, MINT, IntAct, BioGRID	empirical	8159721 9507011 16407974 9824680 7568177 19497860
TCF3	TAL2	HPRD	empirical	8152805
TCF3	TCF4	BioGRID	empirical	20211142
TCF3	TCF3	HPRD, IntAct, BioGRID	empirical	8628307 8948587 8900141 9584154 10567574 1649701 15351717 7623842 2503252 9409784 10915743 12435739
TCF3	TCF12	HPRD	empirical	1446075 12566462
TCF3	TCF21	HPRD, MINT, IntAct	empirical	11591653
TCF3	TWIST1	HPRD, MIPS, BioGRID	empirical	10749989 10567574
TCF3	UBC	BioGRID	empirical	21119685
TCF3	UBE2I	HPRD, IntAct, BioGRID	empirical	10497239 9409784
TCF3	VDR	BioGRID	empirical	16252006 15934135 17250953
TCF3	YY1	BioGRID	empirical	17721549
TCF3	MAPKAPK3	HPRD, BioGRID	empirical	10781029
TCF3	CALM1	HPRD	empirical	10757985
TCF3	CALM3	HPRD	empirical	10757985
TCF3	RUVBL1	IntAct	empirical	16230350
TCF3	RUNX1	BioGRID	empirical	15333839
TCF3	RUNX1T1	HPRD, BioGRID	empirical	15333839
TCF3	CBFA2T3	MINT, BioGRID	empirical	16407974
TCF3	KAT2B	HPRD, BioGRID	empirical	12435739
TCF3	LDB1	BioGRID	empirical	16407974
TCF3	BAZ1B	BioGRID	empirical	16252006
TCF3	MSC	HPRD	empirical	9584154
TCF3	MAPKAPK2	HPRD	empirical	10781029
TCF3	HAND1	HPRD, IntAct	empirical	11802795 10924525
TCF3	HAND2	HPRD, IntAct, BioGRID	empirical	11812799 15351717 10924525
TCF3	NCOR1	BioGRID	empirical	16252006 15934135