Home TAL1
|
(Human) GRCh37 - chr1:47681963..47697892 (15.93 kb) View in Genome Browser
(Mouse) NCBIM37 - chr4:114729031..114744360 (15.33 kb) View in Genome Browser
(Rat) RGSC3.4 - chr5:135430985..135444692 (13.71 kb) View in Genome Browser
HaemAtlas Expression Table for TAL1:|
Expression Legend
|
|
|
Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
| no data | no data | |||||||||||
Expression Legend
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
| Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Expression Legend
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for TAL1:The TAL1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| TAL1 | CDK9 | IntAct, BioGRID | empirical | 20603019 |
| TAL1 | STUB1 | HPRD, BioGRID | empirical | 17962192 |
| TAL1 | RCC1 | MINT, BioGRID | empirical | 16407974 |
| TAL1 | CHD3 | HPRD, BioGRID | empirical | 15383276 19497860 |
| TAL1 | CHD4 | BioGRID | empirical | 19497860 |
| TAL1 | SUPT16H | IntAct, BioGRID | empirical | 20603019 |
| TAL1 | ZHX1 | HPRD | empirical | 15383276 |
| TAL1 | CRK | IntAct | empirical | 17474147 |
| TAL1 | PARP1 | MINT, BioGRID | empirical | 16407974 |
| TAL1 | EP300 | HPRD, BioGRID | empirical | 10490830 |
| TAL1 | KDM1A | BioGRID | empirical | 19497860 |
| TAL1 | RCOR1 | BioGRID | empirical | 19497860 |
| TAL1 | SSBP2 | MINT, BioGRID | empirical | 16407974 19497860 |
| TAL1 | SSBP3 | MINT, BioGRID | empirical | 16407974 19497860 |
| TAL1 | BRD1 | MINT | empirical | 16407974 |
| TAL1 | XRCC6 | MINT, BioGRID | empirical | 16407974 |
| TAL1 | SIN3A | HPRD, BioGRID | empirical | 10688671 |
| TAL1 | GATA1 | MINT, IntAct, BioGRID | empirical | 16407974 7568177 15920471 |
| TAL1 | GATA2 | IntAct, BioGRID | empirical | 7568177 |
| TAL1 | GATA3 | HPRD, BioGRID | empirical | 9819382 |
| TAL1 | HTT | BioGRID | empirical | 15383276 |
| TAL1 | HDAC1 | HPRD, MINT, BioGRID | empirical | 10688671 16407974 19497860 |
| TAL1 | HDAC2 | MINT, BioGRID | empirical | 16407974 19497860 |
| TAL1 | HOXB9 | IntAct | empirical | 21988832 |
| TAL1 | LMO1 | HPRD, BioGRID | empirical | 8078932 7957052 |
| TAL1 | LMO2 | HPRD, MINT, IntAct, BioGRID | empirical | 8078932 7568177 7957052 9209374 16407974 |
| TAL1 | LYL1 | BioGRID | empirical | 19497860 |
| TAL1 | DRG1 | HPRD, IntAct | empirical | 9824680 |
| TAL1 | TRIM33 | IntAct, BioGRID | empirical | 20603019 |
| TAL1 | NCAPG2 | HPRD, BioGRID | empirical | 14729962 |
| TAL1 | PRKCQ | BioGRID | empirical | 10383400 |
| TAL1 | LMO3 | BioGRID | empirical | 20211142 |
| TAL1 | MAPK3 | HPRD | empirical | 8423803 |
| TAL1 | RB1 | BioGRID | empirical | 19497860 10866689 |
| TAL1 | RBBP7 | BioGRID | empirical | 19497860 |
| TAL1 | TRIM27 | BioGRID | empirical | 16007160 |
| TAL1 | SATB1 | BioGRID | empirical | 15677454 |
| TAL1 | ELSPBP1 | HPRD | empirical | 8159721 |
| TAL1 | SKP2 | HPRD, BioGRID | empirical | 17962192 |
| TAL1 | SP1 | HPRD, BioGRID | empirical | 12239153 |
| TAL1 | SSBP1 | BioGRID | empirical | 16407974 |
| TAL1 | SUV39H1 | BioGRID | empirical | 15677454 |
| TAL1 | TAL1 | BioGRID | empirical | 20603019 |
| TAL1 | TCF4 | MINT, IntAct, BioGRID | empirical | 16407974 9824680 8576241 9242638 |
| TAL1 | TCF3 | HPRD, MINT, IntAct, BioGRID | empirical | 8159721 9507011 16407974 9824680 7568177 19497860 |
| TAL1 | TCF12 | MINT, IntAct, BioGRID | empirical | 16407974 9824680 19497860 |
| TAL1 | TOP1 | MINT, BioGRID | empirical | 16407974 |
| TAL1 | UBC | BioGRID | empirical | 17962192 11904294 |
| TAL1 | TRRAP | MINT, BioGRID | empirical | 16407974 |
| TAL1 | RUNX1 | BioGRID | empirical | 19497860 |
| TAL1 | CBFA2T3 | MINT, BioGRID | empirical | 16407974 19497860 |
| TAL1 | KAT2B | HPRD | empirical | 11118214 |
| TAL1 | LDB1 | MINT, BioGRID | empirical | 16407974 15920471 19497860 |
| TAL1 | CBFA2T2 | MINT, BioGRID | empirical | 16407974 |
|
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
Publications: 237
-
Etv2/ER71 induces vascular mesoderm from Flk1+PDGFRα+ primitive mesoderm.
Kataoka H, Hayashi M, Nakagawa R, Tanaka Y, Izumi N, Nishikawa S, Jakt ML, Tarui H, Nishikawa S
Blood. 2011
PubMed ID: 21911838
-
TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells.
Cardoso BA, de Almeida SF, Laranjeira AB, Carmo-Fonseca M, Yunes JA, Coffer PJ, Barata JT
Leukemia. 2011
PubMed ID: 21647153
-
Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.
Tatarek J, Cullion K, Ashworth T, Gerstein R, Aster JC, Kelliher MA
Blood. 2011
PubMed ID: 21670468
-
SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis.
Chagraoui H, Kassouf M, Banerjee S, Goardon N, Clark K, Atzberger A, Pearce AC, Skoda RC, Ferguson DJ, Watson SP, Vyas P, Porcher C
Blood. 2011
PubMed ID: 21596846
-
Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.
Tijssen MR, Cvejic A, Joshi A, Hannah RL, Ferreira R, Forrai A, Bellissimo DC, Oram SH, Smethurst PA, Wilson NK, Wang X, Ottersbach K, Stemple DL, Green AR, Ouwehand WH, Göttgens B
Dev Cell. 2011
PubMed ID: 21571218
-
Adult hematopoiesis is regulated by TIF1γ, a repressor of TAL1 and PU.1 transcriptional activity.
Kusy S, Gault N, Ferri F, Lewandowski D, Barroca V, Jaracz-Ros A, Losson R, Romeo PH
Cell Stem Cell. 2011
PubMed ID: 21474105
-
A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.
Draheim KM, Hermance N, Yang Y, Arous E, Calvo J, Kelliher MA
Oncogene. 2011
PubMed ID: 21057528
-
Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages.
Palii CG, Perez-Iratxeta C, Yao Z, Cao Y, Dai F, Davison J, Atkins H, Allan D, Dilworth FJ, Gentleman R, Tapscott SJ, Brand M
EMBO J. 2011
PubMed ID: 21179004
-
Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity.
Jeong Y, Dolson DK, Waclaw RR, Matise MP, Sussel L, Campbell K, Kaestner KH, Epstein DJ
Development. 2011
PubMed ID: 21205797
-
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
-
Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.
Wilson NK, Foster SD, Wang X, Knezevic K, Schütte J, Kaimakis P, Chilarska PM, Kinston S, Ouwehand WH, Dzierzak E, Pimanda JE, de Bruijn MF, Göttgens B
Cell Stem Cell. 2010
PubMed ID: 20887958
-
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
-
NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia.
Kusy S, Gerby B, Goardon N, Gault N, Ferri F, Gérard D, Armstrong F, Ballerini P, Cayuela JM, Baruchel A, Pflumio F, Roméo PH
J Exp Med. 2010
PubMed ID: 20855495
-
Vegf regulates embryonic erythroid development through Gata1 modulation.
Drogat B, Kalucka J, Gutiérrez L, Hammad H, Goossens S, Farhang Ghahremani M, Bartunkova S, Haigh K, Deswarte K, Nyabi O, Naessens M, Ferrara N, Klingmüller U, Lambrecht BN, Nagy A, Philipsen S, Haigh JJ
Blood. 2010
PubMed ID: 20554972
-
A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model.
Nagamachi A, Htun PW, Ma F, Miyazaki K, Yamasaki N, Kanno M, Inaba T, Honda Z, Okuda T, Oda H, Tsuji K, Honda H
Dev Biol. 2010
PubMed ID: 20647008
-
Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands.
Tsunoda T, Takashima Y, Tanaka Y, Fujimoto T, Doi K, Hirose Y, Koyanagi M, Yoshida Y, Okamura T, Kuroki M, Sasazuki T, Shirasawa S
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20660741
-
Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells.
Kassouf MT, Hughes JR, Taylor S, McGowan SJ, Soneji S, Green AL, Vyas P, Porcher C
Genome Res. 2010
PubMed ID: 20566737
-
TIF1gamma controls erythroid cell fate by regulating transcription elongation.
Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI
Cell. 2010
PubMed ID: 20603019
-
Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.
Tremblay M, Tremblay CS, Herblot S, Aplan PD, Hébert J, Perreault C, Hoang T
Genes Dev. 2010
PubMed ID: 20516195
-
The TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursors.
Dey S, Curtis DJ, Jane SM, Brandt SJ
Mol Cell Biol. 2010
PubMed ID: 20194619
-
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
-
Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1.
Lausen J, Pless O, Leonard F, Kuvardina ON, Koch B, Leutz A
J Biol Chem. 2010
PubMed ID: 20028976
-
Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias.
Carbuccia N, Trouplin V, Gelsi-Boyer V, Murati A, Rocquain J, Adélaïde J, Olschwang S, Xerri L, Vey N, Chaffanet M, Birnbaum D, Mozziconacci MJ
Leukemia. 2010
PubMed ID: 19865112
-
Scl regulates the quiescence and the long-term competence of hematopoietic stem cells.
Lacombe J, Herblot S, Rojas-Sutterlin S, Haman A, Barakat S, Iscove NN, Sauvageau G, Hoang T
Blood. 2010
PubMed ID: 19850742
-
Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development.
He Y, Zhang H, Yu L, Gunel M, Boggon TJ, Chen H, Min W
Sci Signal. 2010
PubMed ID: 20371769
-
Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus.
Dhami P, Bruce AW, Jim JH, Dillon SC, Hall A, Cooper JL, Bonhoure N, Chiang K, Ellis PD, Langford C, Andrews RM, Vetrie D
PLoS One. 2010
PubMed ID: 20140202
-
Enhanced hematovascular contribution of SCL 3' enhancer expressing fetal liver cells uncovers their potential to integrate in extramedullary adult niches.
Garcia-Ortega AM, Cañete A, Quinter C, Silberstein L, Piquer-Gil M, Alvarez-Dolado M, Dekel B, Gottgens B, Sánchez MJ
Stem Cells. 2010
PubMed ID: 19785037
-
Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors.
Cai Y, Xu Z, Xie J, Ham AJ, Koury MJ, Hiebert SW, Brandt SJ
Biochem Biophys Res Commun. 2009
PubMed ID: 19799863
-
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
-
Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification.
Gandillet A, Serrano AG, Pearson S, Lie-A-Ling M, Lacaud G, Kouskoff V
Blood. 2009
PubMed ID: 19801444
-
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
-
Defective erythropoiesis in transgenic mice expressing dominant-negative upstream stimulatory factor.
Liang SY, Moghimi B, Crusselle-Davis VJ, Lin IJ, Rosenberg MH, Li X, Strouboulis J, Huang S, Bungert J
Mol Cell Biol. 2009
PubMed ID: 19704006
-
Inhibition of the hTERT promoter by the proto-oncogenic protein TAL1.
Terme JM, Mocquet V, Kuhlmann AS, Zane L, Mortreux F, Wattel E, Duc Dodon M, Jalinot P
Leukemia. 2009
PubMed ID: 19587703
-
In vivo fate mapping with SCL regulatory elements identifies progenitors for primitive and definitive hematopoiesis in mice.
Bockamp E, Antunes C, Liebner S, Schmitt S, Cabezas-Wallscheid N, Heck R, Ohnngemach S, Oesch-Bartlomowicz B, Rickert C, Sanchez MJ, Hengstler J, Kaina B, Wilson A, Trumpp A, Eshkind L
Mech Dev. 2009
PubMed ID: 19631738
-
Expression of Scl in mesoderm rescues hematopoiesis in the absence of Oct-4.
Kong KY, Williamson EA, Rogers JH, Tran T, Hromas R, Dahl R
Blood. 2009
PubMed ID: 19321862
-
TGF-beta induces degradation of TAL1/SCL by the ubiquitin-proteasome pathway through AKT-mediated phosphorylation.
Terme JM, Lhermitte L, Asnafi V, Jalinot P
Blood. 2009
PubMed ID: 19406989
-
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis.
Hu X, Li X, Valverde K, Fu X, Noguchi C, Qiu Y, Huang S
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19497860
-
Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.
Corrigan PM, Dobbin E, Freeburn RW, Wheadon H
Stem Cells Dev. 2009
PubMed ID: 18800919
-
The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development.
Wilson NK, Miranda-Saavedra D, Kinston S, Bonadies N, Foster SD, Calero-Nieto F, Dawson MA, Donaldson IJ, Dumon S, Frampton J, Janky R, Sun XH, Teichmann SA, Bannister AJ, Göttgens B
Blood. 2009
PubMed ID: 19346495
-
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
-
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.
Gekas C, Rhodes KE, Gereige LM, Helgadottir H, Ferrari R, Kurdistani SK, Montecino-Rodriguez E, Bassel-Duby R, Olson E, Krivtsov AV, Armstrong S, Orkin SH, Pellegrini M, Mikkola HK
Blood. 2009
PubMed ID: 19211936
-
LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons.
Joshi K, Lee S, Lee B, Lee JW, Lee SK
Neuron. 2009
PubMed ID: 19323994
-
SCL and associated proteins distinguish active from repressive GATA transcription factor complexes.
Tripic T, Deng W, Cheng Y, Zhang Y, Vakoc CR, Gregory GD, Hardison RC, Blobel GA
Blood. 2009
PubMed ID: 19011221
-
The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage.
Lancrin C, Sroczynska P, Stephenson C, Allen T, Kouskoff V, Lacaud G
Nature. 2009
PubMed ID: 19182774
-
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival.
Souroullas GP, Salmon JM, Sablitzky F, Curtis DJ, Goodell MA
Cell Stem Cell. 2009
PubMed ID: 19200805
-
[The bHLH TAL1 protein: a key molecule in the hematopoietic and endothelial systems]
Mathieu D
J Soc Biol. 2009
PubMed ID: 19527627
-
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.
Wilson A, Laurenti E, Oser G, van der Wath RC, Blanco-Bose W, Jaworski M, Offner S, Dunant CF, Eshkind L, Bockamp E, Lió P, Macdonald HR, Trumpp A
Cell. 2008
PubMed ID: 19062086
-
Mesodermal patterning activity of SCL.
Ismailoglu I, Yeamans G, Daley GQ, Perlingeiro RC, Kyba M
Exp Hematol. 2008
PubMed ID: 18809240
-
Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code.
Pimanda JE, Chan WY, Wilson NK, Smith AM, Kinston S, Knezevic K, Janes ME, Landry JR, Kolb-Kokocinski A, Frampton J, Tannahill D, Ottersbach K, Follows GA, Lacaud G, Kouskoff V, Göttgens B
Blood. 2008
PubMed ID: 18805961
-
Molecular hallmarks of endogenous chromatin complexes containing master regulators of hematopoiesis.
Wozniak RJ, Keles S, Lugus JJ, Young KH, Boyer ME, Tran TM, Choi K, Bresnick EH
Mol Cell Biol. 2008
PubMed ID: 18779319
-
Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.
Stevens JD, Roalson EH, Skinner MK
Differentiation. 2008
PubMed ID: 18557763
-
Cell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis.
Goldie LC, Lucitti JL, Dickinson ME, Hirschi KK
Blood. 2008
PubMed ID: 18684862
-
Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development.
Lavine KJ, Long F, Choi K, Smith C, Ornitz DM
Development. 2008
PubMed ID: 18725519
-
Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis.
Kassouf MT, Chagraoui H, Vyas P, Porcher C
Blood. 2008
PubMed ID: 18550854
-
Cross talk between expression of the human T-cell leukemia virus type 1 Tax transactivator and the oncogenic bHLH transcription factor TAL1.
Terme JM, Wencker M, Favre-Bonvin A, Bex F, Gazzolo L, Duc Dodon M, Jalinot P
J Virol. 2008
PubMed ID: 18495761
-
Impairment of granulo-monocytic development of human common myeloid progenitors but not of granulo-monocytic progenitors by decreasing stem cell leukemia/T-cell acute leukemia 1 expression.
Brunet Pde L, Zink E, Armstrong F, Rouyez MC, Pflumio F
Stem Cells. 2008
PubMed ID: 18436863
-
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
-
Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.
Landry JR, Kinston S, Knezevic K, de Bruijn MF, Wilson N, Nottingham WT, Peitz M, Edenhofer F, Pimanda JE, Ottersbach K, Göttgens B
Blood. 2008
PubMed ID: 18184866
-
V(D)J recombinase binding and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies.
Zhang M, Swanson PC
J Biol Chem. 2008
PubMed ID: 18187418
-
Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12.
Ryan DP, Duncan JL, Lee C, Kuchel PW, Matthews JM
Proteins. 2008
PubMed ID: 17910069
-
Identification of erythroid-enriched gene expression in the mouse embryonic yolk sac using microdissected cells.
Redmond LC, Dumur CI, Archer KJ, Haar JL, Lloyd JA
Dev Dyn. 2008
PubMed ID: 18213587
-
Ubiquitination and degradation of Tal1/SCL are induced by notch signaling and depend on Skp2 and CHIP.
Nie L, Wu H, Sun XH
J Biol Chem. 2008
PubMed ID: 17962192
-
Does TAL-1 deletion contribute to the high incidence of T-cell acute lymphoblastic leukemia in South Indian patients?
N S, Nirmal KA, Rajalekshmy KR, Rajkumar T
Asian Pac J Cancer Prev. 2008
PubMed ID: 18439091
-
Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.
Nottingham WT, Jarratt A, Burgess M, Speck CL, Cheng JF, Prabhakar S, Rubin EM, Li PS, Sloane-Stanley J, Kong-A-San J, de Bruijn MF
Blood. 2007
PubMed ID: 17823307
-
Protein stability and transcription factor complex assembly determined by the SCL-LMO2 interaction.
Lécuyer E, Larivière S, Sincennes MC, Haman A, Lahlil R, Todorova M, Tremblay M, Wilkes BC, Hoang T
J Biol Chem. 2007
PubMed ID: 17878155
-
NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis.
Göthert JR, Brake RL, Smeets M, Dührsen U, Begley CG, Izon DJ
Blood. 2007
PubMed ID: 17698635
-
Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene.
Salmon JM, Slater NJ, Hall MA, McCormack MP, Nutt SL, Jane SM, Curtis DJ
Blood. 2007
PubMed ID: 17644741
-
Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development.
Pimanda JE, Ottersbach K, Knezevic K, Kinston S, Chan WY, Wilson NK, Landry JR, Wood AD, Kolb-Kokocinski A, Green AR, Tannahill D, Lacaud G, Kouskoff V, Göttgens B
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17962413
-
A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool.
Del Barrio MG, Taveira-Marques R, Muroyama Y, Yuk DI, Li S, Wines-Samuelson M, Shen J, Smith HK, Xiang M, Rowitch D, Richardson WD
Development. 2007
PubMed ID: 17728344
-
The SCL +40 enhancer targets the midbrain together with primitive and definitive hematopoiesis and is regulated by SCL and GATA proteins.
Ogilvy S, Ferreira R, Piltz SG, Bowen JM, Göttgens B, Green AR
Mol Cell Biol. 2007
PubMed ID: 17709394
-
p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.
Fasseu M, Aplan PD, Chopin M, Boissel N, Bories JC, Soulier J, von Boehmer H, Sigaux F, Regnault A
Blood. 2007
PubMed ID: 17507663
-
Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems.
Taylor MK, Yeager K, Morrison SJ
Development. 2007
PubMed ID: 17537790
-
The notch pathway positively regulates programmed cell death during erythroid differentiation.
Robert-Moreno A, Espinosa L, Sanchez MJ, de la Pompa JL, Bigas A
Leukemia. 2007
PubMed ID: 17476283
-
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
Wu C, Ma MH, Brown KR, Geisler M, Li L, Tzeng E, Jia CY, Jurisica I, Li SS
Proteomics. 2007
PubMed ID: 17474147
-
Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis.
Ueda T, Watanabe-Fukunaga R, Ogawa H, Fukuyama H, Higashi Y, Nagata S, Fukunaga R
Genes Cells. 2007
PubMed ID: 17535249
-
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1.
Tsuzuki S, Hong D, Gupta R, Matsuo K, Seto M, Enver T
PLoS Med. 2007
PubMed ID: 17503961
-
Cre-loxP-mediated recombination between the SIL and SCL genes leads to a block in T-cell development at the CD4- CD8- to CD4+ CD8+ transition.
Cheng Y, Zhang Z, Slape C, Aplan PD
Neoplasia. 2007
PubMed ID: 17460775
-
Temporal regulation of Cre-recombinase activity in Scl-positive neurons of the central nervous system.
Bradley CK, Takano EA, Göthert JR, Göttgens B, Green AR, Begley CG, van Eekelen JA
Genesis. 2007
PubMed ID: 17330263
-
The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.
Chan WY, Follows GA, Lacaud G, Pimanda JE, Landry JR, Kinston S, Knezevic K, Piltz S, Donaldson IJ, Gambardella L, Sablitzky F, Green AR, Kouskoff V, Göttgens B
Blood. 2007
PubMed ID: 17053063
-
lyl-1 and tal-1/scl, two genes encoding closely related bHLH transcription factors, display highly overlapping expression patterns during cardiovascular and hematopoietic ontogeny.
Giroux S, Kaushik AL, Capron C, Jalil A, Kelaidi C, Sablitzky F, Dumenil D, Albagli O, Godin I
Gene Expr Patterns. 2007
PubMed ID: 17112790
-
The SCL 3' enhancer responds to Hedgehog signaling during hemangioblast specification.
Hochman E, Kinston S, Harmelin A, Göttgens B, Izraeli S
Exp Hematol. 2006
PubMed ID: 17157160
-
Low SCL/TAL1 expression reveals its major role in adult hematopoietic myeloid progenitors and stem cells.
Brunet de la Grange P, Armstrong F, Duval V, Rouyez MC, Goardon N, Romeo PH, Pflumio F
Blood. 2006
PubMed ID: 16849639
-
A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis.
McCormack MP, Hall MA, Schoenwaelder SM, Zhao Q, Ellis S, Prentice JA, Clarke AJ, Slater NJ, Salmon JM, Jackson SP, Jane SM, Curtis DJ
Blood. 2006
PubMed ID: 16763211
-
Tetracycline-controlled transgenic targeting from the SCL locus directs conditional expression to erythrocytes, megakaryocytes, granulocytes, and c-kit-expressing lineage-negative hematopoietic cells.
Bockamp E, Antunes C, Maringer M, Heck R, Presser K, Beilke S, Ohngemach S, Alt R, Cross M, Sprengel R, Hartwig U, Kaina B, Schmitt S, Eshkind L
Blood. 2006
PubMed ID: 16675709
-
Analysis of expansion of myeloid progenitors in mice to identify leukemic susceptibility genes.
Sollars VE, Pequignot E, Rothstein JL, Buchberg AM
Mamm Genome. 2006
PubMed ID: 16897342
-
Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia.
Palomero T, Odom DT, O'Neil J, Ferrando AA, Margolin A, Neuberg DS, Winter SS, Larson RS, Li W, Liu XS, Young RA, Look AT
Blood. 2006
PubMed ID: 16621969
-
NFKB1 is a direct target of the TAL1 oncoprotein in human T leukemia cells.
Chang PY, Draheim K, Kelliher MA, Miyamoto S
Cancer Res. 2006
PubMed ID: 16778171
-
The DNA sequence and biological annotation of human chromosome 1.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E
Nature. 2006
PubMed ID: 16710414
-
p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice.
Shank-Calvo JA, Draheim K, Bhasin M, Kelliher MA
Oncogene. 2006
PubMed ID: 16407836
-
Cross talk among Notch3, pre-TCR, and Tal1 in T-cell development and leukemogenesis.
Talora C, Cialfi S, Oliviero C, Palermo R, Pascucci M, Frati L, Vacca A, Gulino A, Screpanti I
Blood. 2006
PubMed ID: 16368887
-
The essential haematopoietic transcription factor Scl is also critical for neuronal development.
Bradley CK, Takano EA, Hall MA, Göthert JR, Harvey AR, Begley CG, van Eekelen JA
Eur J Neurosci. 2006
PubMed ID: 16623824
-
Transcriptional link between blood and bone: the stem cell leukemia gene and its +19 stem cell enhancer are active in bone cells.
Pimanda JE, Silberstein L, Dominici M, Dekel B, Bowen M, Oldham S, Kallianpur A, Brandt SJ, Tannahill D, Göttgens B, Green AR
Mol Cell Biol. 2006
PubMed ID: 16537906
-
Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6.
Matsumoto N, Kubo A, Liu H, Akita K, Laub F, Ramirez F, Keller G, Friedman SL
Blood. 2006
PubMed ID: 16234353
-
ETO2 coordinates cellular proliferation and differentiation during erythropoiesis.
Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T
EMBO J. 2006
PubMed ID: 16407974
-
PU.1/Spi-1 binds to the human TAL-1 silencer to mediate its activity.
Le Clech M, Chalhoub E, Dohet C, Roure V, Fichelson S, Moreau-Gachelin F, Mathieu D
J Mol Biol. 2006
PubMed ID: 16298389
-
ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis.
Schuh AH, Tipping AJ, Clark AJ, Hamlett I, Guyot B, Iborra FJ, Rodriguez P, Strouboulis J, Enver T, Vyas P, Porcher C
Mol Cell Biol. 2005
PubMed ID: 16287841
-
Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube.
Muroyama Y, Fujiwara Y, Orkin SH, Rowitch DH
Nature. 2005
PubMed ID: 16292311
-
RFP represses transcriptional activation by bHLH transcription factors.
Bloor AJ, Kotsopoulou E, Hayward P, Champion BR, Green AR
Oncogene. 2005
PubMed ID: 16007160
-
SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment.
Reynaud D, Ravet E, Titeux M, Mazurier F, Rénia L, Dubart-Kupperschmitt A, Roméo PH, Pflumio F
Blood. 2005
PubMed ID: 15961517
-
Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos.
Maki K, Yamagata T, Asai T, Yamazaki I, Oda H, Hirai H, Mitani K
Blood. 2005
PubMed ID: 15914564
-
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
-
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
-
Functional but abnormal adult erythropoiesis in the absence of the stem cell leukemia gene.
Hall MA, Slater NJ, Begley CG, Salmon JM, Van Stekelenburg LJ, McCormack MP, Jane SM, Curtis DJ
Mol Cell Biol. 2005
PubMed ID: 16024775
-
Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles.
Benedito R, Duarte A
Gene Expr Patterns. 2005
PubMed ID: 15923152
-
GATA-1 forms distinct activating and repressive complexes in erythroid cells.
Rodriguez P, Bonte E, Krijgsveld J, Kolodziej KE, Guyot B, Heck AJ, Vyas P, de Boer E, Grosveld F, Strouboulis J
EMBO J. 2005
PubMed ID: 15920471
-
Transcriptional regulation of the SCL locus: identification of an enhancer that targets the primitive erythroid lineage in vivo.
Delabesse E, Ogilvy S, Chapman MA, Piltz SG, Gottgens B, Green AR
Mol Cell Biol. 2005
PubMed ID: 15923636
-
Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression.
Yuasa H, Oike Y, Iwama A, Nishikata I, Sugiyama D, Perkins A, Mucenski ML, Suda T, Morishita K
EMBO J. 2005
PubMed ID: 15889140
-
SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development.
D'Souza SL, Elefanty AG, Keller G
Blood. 2005
PubMed ID: 15677567
-
Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development.
Schlaeger TM, Mikkola HK, Gekas C, Helgadottir HB, Orkin SH
Blood. 2005
PubMed ID: 15677556
-
Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.
Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP
Development. 2005
PubMed ID: 15843414
-
The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.
Willnow T, Antignac C, Brändli A, Christensen E, Cox R, Davidson D, Davies J, Devuyst O, Eichele G, Hastie N, Verroust P, Schedl A, Meij I
Organogenesis. 2005
PubMed ID: 19521566
-
Tal1/SCL binding to pericentromeric DNA represses transcription.
Wen J, Huang S, Pack SD, Yu X, Brandt SJ, Noguchi CT
J Biol Chem. 2005
PubMed ID: 15677454
-
RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.
Robert-Moreno A, Espinosa L, de la Pompa JL, Bigas A
Development. 2005
PubMed ID: 15689374
-
Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo.
Woda JM, Calzonetti T, Hilditch-Maguire P, Duyao MP, Conlon RA, MacDonald ME
BMC Dev Biol. 2005
PubMed ID: 16109169
-
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
-
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
-
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE
Mol Cell. 2004
PubMed ID: 15383276
-
Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.
Schlaeger TM, Schuh A, Flitter S, Fisher A, Mikkola H, Orkin SH, Vyas P, Porcher C
Mol Cell Biol. 2004
PubMed ID: 15314159
-
Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.
Kaput J, Klein KG, Reyes EJ, Kibbe WA, Cooney CA, Jovanovic B, Visek WJ, Wolff GL
Physiol Genomics. 2004
PubMed ID: 15306695
-
The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis.
Ransom DG, Bahary N, Niss K, Traver D, Burns C, Trede NS, Paffett-Lugassy N, Saganic WJ, Lim CA, Hersey C, Zhou Y, Barut BA, Lin S, Kingsley PD, Palis J, Orkin SH, Zon LI
PLoS Biol. 2004
PubMed ID: 15314655
-
TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.
O'Neil J, Shank J, Cusson N, Murre C, Kelliher M
Cancer Cell. 2004
PubMed ID: 15193261
-
Stem cell leukemia protein directs hematopoietic stem cell fate.
Kunisato A, Chiba S, Saito T, Kumano K, Nakagami-Yamaguchi E, Yamaguchi T, Hirai H
Blood. 2004
PubMed ID: 14726394
-
SCL is required for normal function of short-term repopulating hematopoietic stem cells.
Curtis DJ, Hall MA, Van Stekelenburg LJ, Robb L, Jane SM, Begley CG
Blood. 2004
PubMed ID: 14726374
-
Characterization of DNA-binding-dependent and -independent functions of SCL/TAL1 during human erythropoiesis.
Ravet E, Reynaud D, Titeux M, Izac B, Fichelson S, Roméo PH, Dubart-Kupperschmitt A, Pflumio F
Blood. 2004
PubMed ID: 14715640
-
Kidney, blood, and endothelium: developmental expression of stem cell leukemia during nephrogenesis.
Dekel B, Hochman E, Sanchez MJ, Maharshak N, Amariglio N, Green AR, Izraeli S
Kidney Int. 2004
PubMed ID: 15086455
-
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
-
The bHLH TAL-1/SCL regulates endothelial cell migration and morphogenesis.
Lazrak M, Deleuze V, Noel D, Haouzi D, Chalhoub E, Dohet C, Robbins I, Mathieu D
J Cell Sci. 2004
PubMed ID: 14970264
-
The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1.
Göttgens B, Broccardo C, Sanchez MJ, Deveaux S, Murphy G, Göthert JR, Kotsopoulou E, Kinston S, Delaney L, Piltz S, Barton LM, Knezevic K, Erber WN, Begley CG, Frampton J, Green AR
Mol Cell Biol. 2004
PubMed ID: 14966269
-
SCL assembles a multifactorial complex that determines glycophorin A expression.
Lahlil R, Lécuyer E, Herblot S, Hoang T
Mol Cell Biol. 2004
PubMed ID: 14749362
-
Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a.
Yoshitomi H, Zaret KS
Development. 2004
PubMed ID: 14736742
-
More than blood, a novel gene required for mammalian postimplantation development.
Smith ED, Xu Y, Tomson BN, Leung CG, Fujiwara Y, Orkin SH, Crispino JD
Mol Cell Biol. 2004
PubMed ID: 14729962
-
SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis.
Martin R, Lahlil R, Damert A, Miquerol L, Nagy A, Keller G, Hoang T
Development. 2004
PubMed ID: 14729577
-
The basic helix-loop-helix transcription factor TAL1/SCL inhibits the expression of the p16INK4A and pTalpha genes.
Hansson A, Manetopoulos C, Jönsson JI, Axelson H
Biochem Biophys Res Commun. 2003
PubMed ID: 14651981
-
Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 in erythroid gene expression and differentiation.
Xu Z, Huang S, Chang LS, Agulnick AD, Brandt SJ
Mol Cell Biol. 2003
PubMed ID: 14560005
-
Mouse placenta is a major hematopoietic organ.
Alvarez-Silva M, Belo-Diabangouaya P, Salaün J, Dieterlen-Lièvre F
Development. 2003
PubMed ID: 14507780
-
Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.
Levantini E, Giorgetti A, Cerisoli F, Traggiai E, Guidi A, Martin R, Acampora D, Aplan PD, Keller G, Simeone A, Iscove NN, Hoang T, Magli MC
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12934017
-
Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1.
Zeuner A, Eramo A, Testa U, Felli N, Pelosi E, Mariani G, Srinivasula SM, Alnemri ES, Condorelli G, Peschle C, De Maria R
Cell Death Differ. 2003
PubMed ID: 12867998
-
Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL.
Tremblay M, Herblot S, Lecuyer E, Hoang T
J Biol Chem. 2003
PubMed ID: 12566462
-
The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12.
Hall MA, Curtis DJ, Metcalf D, Elefanty AG, Sourris K, Robb L, Gothert JR, Jane SM, Begley CG
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12552125
-
Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse.
Ema M, Faloon P, Zhang WJ, Hirashima M, Reid T, Stanford WL, Orkin S, Choi K, Rossant J
Genes Dev. 2003
PubMed ID: 12569129
-
Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene.
Mikkola HK, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara Y, Orkin SH
Nature. 2003
PubMed ID: 12540851
-
Expression pattern of the stem cell leukaemia gene in the CNS of the embryonic and adult mouse.
van Eekelen JA, Bradley CK, Göthert JR, Robb L, Elefanty AG, Begley CG, Harvey AR
Neuroscience. 2003
PubMed ID: 14614907
-
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
-
SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation.
Endoh M, Ogawa M, Orkin S, Nishikawa S
EMBO J. 2002
PubMed ID: 12485991
-
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
-
Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression.
Chung YS, Zhang WJ, Arentson E, Kingsley PD, Palis J, Choi K
Development. 2002
PubMed ID: 12403720
-
The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1.
Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T
Blood. 2002
PubMed ID: 12239153
-
Ectopic expression of TAL-1 protein in Ly-6E.1-htal-1 transgenic mice induces defects in B- and T-lymphoid differentiation.
Goardon N, Schuh A, Hajar I, Ma X, Jouault H, Dzierzak E, Roméo PH, Maouche-Chrétien L
Blood. 2002
PubMed ID: 12091340
-
Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.
Göttgens B, Nastos A, Kinston S, Piltz S, Delabesse EC, Stanley M, Sanchez MJ, Ciau-Uitz A, Patient R, Green AR
EMBO J. 2002
PubMed ID: 12065417
-
Coexpression of SCL and GATA3 in the V2 interneurons of the developing mouse spinal cord.
Smith E, Hargrave M, Yamada T, Begley CG, Little MH
Dev Dyn. 2002
PubMed ID: 12112475
-
Rescue of the lethal scl(-/-) phenotype by the human SCL locus.
Sinclair AM, Bench AJ, Bloor AJ, Li J, Göttgens B, Stanley ML, Miller J, Piltz S, Hunter S, Nacheva EP, Sanchez MJ, Green AR
Blood. 2002
PubMed ID: 12010791
-
Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells.
Tang T, Arbiser JL, Brandt SJ
J Biol Chem. 2002
PubMed ID: 11904294
-
Transcriptional regulation of the stem cell leukemia gene (SCL)--comparative analysis of five vertebrate SCL loci.
Göttgens B, Barton LM, Chapman MA, Sinclair AM, Knudsen B, Grafham D, Gilbert JG, Rogers J, Bentley DR, Green AR
Genome Res. 2002
PubMed ID: 11997341
-
Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4.
Angel JM, Richie ER
Mol Carcinog. 2002
PubMed ID: 11813303
-
Selective rescue of early haematopoietic progenitors in Scl(-/-) mice by expressing Scl under the control of a stem cell enhancer.
Sánchez MJ, Bockamp EO, Miller J, Gambardella L, Green AR
Development. 2001
PubMed ID: 11731461
-
scid Thymocytes with TCRbeta gene rearrangements are targets for the oncogenic effect of SCL and LMO1 transgenes.
Chervinsky DS, Lam DH, Melman MP, Gross KW, Aplan PD
Cancer Res. 2001
PubMed ID: 11522630
-
The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice.
O'Neil J, Billa M, Oikemus S, Kelliher M
Oncogene. 2001
PubMed ID: 11439353
-
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
-
Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences.
Göttgens B, Gilbert JG, Barton LM, Grafham D, Rogers J, Bentley DR, Green AR
Genome Res. 2001
PubMed ID: 11156618
-
P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL.
Huang S, Qiu Y, Shi Y, Xu Z, Brandt SJ
EMBO J. 2000
PubMed ID: 11118214
-
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
-
Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos.
Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG
Mech Dev. 2000
PubMed ID: 11044609
-
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
-
A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts.
Vitelli L, Condorelli G, Lulli V, Hoang T, Luchetti L, Croce CM, Peschle C
Mol Cell Biol. 2000
PubMed ID: 10866689
-
Vasculogenesis in the day 6.5 to 9.5 mouse embryo.
Drake CJ, Fleming PA
Blood. 2000
PubMed ID: 10688823
-
mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor.
Huang S, Brandt SJ
Mol Cell Biol. 2000
PubMed ID: 10688671
-
Analysis of vertebrate SCL loci identifies conserved enhancers.
Göttgens B, Barton LM, Gilbert JG, Bench AJ, Sanchez MJ, Bahn S, Mistry S, Grafham D, McMurray A, Vaudin M, Amaya E, Bentley DR, Green AR, Sinclair AM
Nat Biotechnol. 2000
PubMed ID: 10657125
-
A GATA box in the GATA-1 gene hematopoietic enhancer is a critical element in the network of GATA factors and sites that regulate this gene.
Nishimura S, Takahashi S, Kuroha T, Suwabe N, Nagasawa T, Trainor C, Yamamoto M
Mol Cell Biol. 2000
PubMed ID: 10611250
-
SCL expression in the mouse embryo detected with a targeted lacZ reporter gene demonstrates its localization to hematopoietic, vascular, and neural tissues.
Elefanty AG, Begley CG, Hartley L, Papaevangeliou B, Robb L
Blood. 1999
PubMed ID: 10572089
-
Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse.
Palis J, Robertson S, Kennedy M, Wall C, Keller G
Development. 1999
PubMed ID: 10529424
-
p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein.
Huang S, Qiu Y, Stein RW, Brandt SJ
Oncogene. 1999
PubMed ID: 10490830
-
An SCL 3' enhancer targets developing endothelium together with embryonic and adult haematopoietic progenitors.
Sánchez M, Göttgens B, Sinclair AM, Stanley M, Begley CG, Hunter S, Green AR
Development. 1999
PubMed ID: 10433917
-
Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fyn.
Ron D, Napolitano EW, Voronova A, Vasquez NJ, Roberts DN, Calio BL, Caothien RH, Pettiford SM, Wellik S, Mandac JB, Kauvar LM
J Biol Chem. 1999
PubMed ID: 10383400
-
Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice.
Chervinsky DS, Zhao XF, Lam DH, Ellsworth M, Gross KW, Aplan PD
Mol Cell Biol. 1999
PubMed ID: 10373552
-
Distinct 5' SCL enhancers direct transcription to developing brain, spinal cord, and endothelium: neural expression is mediated by GATA factor binding sites.
Sinclair AM, Göttgens B, Barton LM, Stanley ML, Pardanaud L, Klaine M, Gering M, Bahn S, Sanchez M, Bench AJ, Fordham JL, Bockamp E, Green AR
Dev Biol. 1999
PubMed ID: 10208748
-
Intersections between blood cell development and leukemia genes.
Orkin SH, Porcher C, Fujiwara Y, Visvader J, Wang LC
Cancer Res. 1999
PubMed ID: 10197597
-
The leukemic oncogene tal-2 is expressed in the developing mouse brain.
Mori S, Sugawara S, Kikuchi T, Tanji M, Narumi O, Stoykova A, Nishikawa SI, Yokota Y
Brain Res Mol Brain Res. 1999
PubMed ID: 9931488
-
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
-
The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development.
Greene WK, Bahn S, Masson N, Rabbitts TH
Mol Cell Biol. 1998
PubMed ID: 9819390
-
TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3.
Ono Y, Fukuhara N, Yoshie O
Mol Cell Biol. 1998
PubMed ID: 9819382
-
SCL binds the human homologue of DRG in vivo.
Zhao XF, Aplan PD
Biochim Biophys Acta. 1998
PubMed ID: 9824680
-
AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene.
Okada H, Watanabe T, Niki M, Takano H, Chiba N, Yanai N, Tani K, Hibino H, Asano S, Mucenski ML, Ito Y, Noda T, Satake M
Oncogene. 1998
PubMed ID: 9811459
-
Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ "knock-in" strategy.
Elefanty AG, Begley CG, Metcalf D, Barnett L, Köntgen F, Robb L
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9751762
-
The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition.
Park ST, Sun XH
J Biol Chem. 1998
PubMed ID: 9507011
-
Gene organization and chromosome location of the neural-specific RNA binding protein Elavl4.
Inman MV, Levy S, Mock BA, Owens GC
Gene. 1998
PubMed ID: 9524251
-
Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development.
Visvader JE, Fujiwara Y, Orkin SH
Genes Dev. 1998
PubMed ID: 9472016
-
The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.
Visvader JE, Mao X, Fujiwara Y, Hahm K, Orkin SH
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9391090
-
Hematopoietic-specific genes are not induced during in vitro differentiation of scl-null embryonic stem cells.
Elefanty AG, Robb L, Birner R, Begley CG
Blood. 1997
PubMed ID: 9269761
-
Differential interactions of Id proteins with basic-helix-loop-helix transcription factors.
Langlands K, Yin X, Anand G, Prochownik EV
J Biol Chem. 1997
PubMed ID: 9242638
-
The SCL/TAL1 gene: roles in normal and malignant haematopoiesis.
Robb L, Begley CG
Bioessays. 1997
PubMed ID: 9230693
-
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.
Watanabe N, Madaule P, Reid T, Ishizaki T, Watanabe G, Kakizuka A, Saito Y, Nakao K, Jockusch BM, Narumiya S
EMBO J. 1997
PubMed ID: 9214622
-
Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development.
Biben C, Harvey RP
Genes Dev. 1997
PubMed ID: 9192865
-
An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice.
Aplan PD, Jones CA, Chervinsky DS, Zhao X, Ellsworth M, Wu C, McGuire EA, Gross KW
EMBO J. 1997
PubMed ID: 9171354
-
Target-dependent effect of phosphorylation on the DNA binding activity of the TAL1/SCL oncoprotein.
Prasad KS, Brandt SJ
J Biol Chem. 1997
PubMed ID: 9111058
-
LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1.
Osada H, Grutz GG, Axelson H, Forster A, Rabbitts TH
Leukemia. 1997
PubMed ID: 9209374
-
Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and Tal-1 (SCL).
Lowsky R, DeCoteau JF, Reitmair AH, Ichinohasama R, Dong WF, Xu Y, Mak TW, Kadin ME, Minden MD
Blood. 1997
PubMed ID: 9116269
-
Distinct mechanisms direct SCL/tal-1 expression in erythroid cells and CD34 positive primitive myeloid cells.
Bockamp EO, McLaughlin F, Göttgens B, Murrell AM, Elefanty AG, Green AR
J Biol Chem. 1997
PubMed ID: 9079714
-
Initiation of murine embryonic erythropoiesis: a spatial analysis.
Silver L, Palis J
Blood. 1997
PubMed ID: 9028937
-
Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha.
Kelliher MA, Seldin DC, Leder P
EMBO J. 1996
PubMed ID: 8895560
-
The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.
Robb L, Elwood NJ, Elefanty AG, Köntgen F, Li R, Barnett LD, Begley CG
EMBO J. 1996
PubMed ID: 8861941
-
The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation.
Hofmann TJ, Cole MD
Oncogene. 1996
PubMed ID: 8760303
-
Determinants of helix-loop-helix dimerization affinity. Random mutational analysis of SCL/tal.
Goldfarb AN, Lewandowska K, Shoham M
J Biol Chem. 1996
PubMed ID: 8576241
-
Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1.
Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7568177
-
Lineage-restricted regulation of the murine SCL/TAL-1 promoter.
Bockamp EO, McLaughlin F, Murrell AM, Göttgens B, Robb L, Begley CG, Green AR
Blood. 1995
PubMed ID: 7632958
-
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.
Robb L, Lyons I, Li R, Hartley L, Köntgen F, Harvey RP, Metcalf D, Begley CG
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7624372
-
Discordant regulation of SCL/TAL-1 mRNA and protein during erythroid differentiation.
Murrell AM, Bockamp EO, Göttgens B, Chan YS, Cross MA, Heyworth CM, Green AR
Oncogene. 1995
PubMed ID: 7624120
-
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL.
Shivdasani RA, Mayer EL, Orkin SH
Nature. 1995
PubMed ID: 7830794
-
Expression of TAL-1 proteins in human tissues.
Pulford K, Lecointe N, Leroy-Viard K, Jones M, Mathieu-Mahul D, Mason DY
Blood. 1995
PubMed ID: 7833471
-
Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.
Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R
EMBO J. 1994
PubMed ID: 7957052
-
Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line.
Cross MA, Heyworth CM, Murrell AM, Bockamp EO, Dexter TM, Green AR
Oncogene. 1994
PubMed ID: 8084606
-
GATA-and SP1-binding sites are required for the full activity of the tissue-specific promoter of the tal-1 gene.
Lecointe N, Bernard O, Naert K, Joulin V, Larsen CJ, Romeo PH, Mathieu-Mahul D
Oncogene. 1994
PubMed ID: 8058326
-
The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells.
Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8078932
-
The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development.
Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, Rabbitts TH
Cell. 1994
PubMed ID: 8033210
-
Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells.
Hsu HL, Wadman I, Baer R
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8159721
-
The SCL/TAL-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis.
Kallianpur AR, Jordan JE, Brandt SJ
Blood. 1994
PubMed ID: 8118024
-
Structure of the gene encoding the murine SCL protein.
Begley CG, Robb L, Rockman S, Visvader J, Bockamp EO, Chan YS, Green AR
Gene. 1994
PubMed ID: 8125323
-
TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia.
Baer R
Semin Cancer Biol. 1993
PubMed ID: 8142619
-
Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen.
Hwang LY, Siegelman M, Davis L, Oppenheimer-Marks N, Baer R
Oncogene. 1993
PubMed ID: 8414504
-
Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency.
Berry MJ, Grieco D, Taylor BA, Maia AL, Kieffer JD, Beamer W, Glover E, Poland A, Larsen PR
J Clin Invest. 1993
PubMed ID: 8104199
-
Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues.
Cheng JT, Hsu HL, Hwang LY, Baer R
Oncogene. 1993
PubMed ID: 8437851
-
Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1.
Cheng JT, Cobb MH, Baer R
Mol Cell Biol. 1993
PubMed ID: 8423803
-
Expression of tal-1 and GATA-binding proteins during human hematopoiesis.
Mouthon MA, Bernard O, Mitjavila MT, Romeo PH, Vainchenker W, Mathieu-Mahul D
Blood. 1993
PubMed ID: 7678994
-
The mouse intracisternal A particle-promoted placental gene retrotransposition is mouse-strain-specific.
Chang-Yeh A, Mold DE, Brilliant MH, Huang RC
Proc Natl Acad Sci U S A. 1993
PubMed ID: 7678343
-
T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein.
Goldfarb AN, Goueli S, Mickelson D, Greenberg JM
Blood. 1992
PubMed ID: 1450410
-
The SCL gene product: a positive regulator of erythroid differentiation.
Aplan PD, Nakahara K, Orkin SH, Kirsch IR
EMBO J. 1992
PubMed ID: 1396592
-
SCL and related hemopoietic helix-loop-helix transcription factors.
Green AR, Begley CG
Int J Cell Cloning. 1992
PubMed ID: 1453013
-
Expression of murine cyclin B1 mRNAs and genetic mapping of related genomic sequences.
Hanley-Hyde J, Mushinski JF, Sadofsky M, Huppi K, Krall M, Kozak CA, Mock B
Genomics. 1992
PubMed ID: 1387105
-
Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.
Aplan PD, Lombardi DP, Reaman GH, Sather HN, Hammond GD, Kirsch IR
Blood. 1992
PubMed ID: 1311214
-
Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene.
Bernard O, Lecointe N, Jonveaux P, Souyri M, Mauchauffé M, Berger R, Larsen CJ, Mathieu-Mahul D
Oncogene. 1991
PubMed ID: 1886719
-
Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL.
Begley CG, Visvader J, Green AR, Aplan PD, Metcalf D, Kirsch IR, Gough NM
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1704135
-
The SCL gene is formed from a transcriptionally complex locus.
Aplan PD, Begley CG, Bertness V, Nussmeier M, Ezquerra A, Coligan J, Kirsch IR
Mol Cell Biol. 1990
PubMed ID: 2247063
-
Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.
Chen Q, Yang CY, Tsan JT, Xia Y, Ragab AH, Peiper SC, Carroll A, Baer R
J Exp Med. 1990
PubMed ID: 2230650
-
The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.
Chen Q, Cheng JT, Tasi LH, Schneider N, Buchanan G, Carroll A, Crist W, Ozanne B, Siciliano MJ, Baer R
EMBO J. 1990
PubMed ID: 2303035
-
Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias.
Bernard O, Guglielmi P, Jonveaux P, Cherif D, Gisselbrecht S, Mauchauffe M, Berger R, Larsen CJ, Mathieu-Mahul D
Genes Chromosomes Cancer. 1990
PubMed ID: 1964581
-
The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.
Begley CG, Aplan PD, Denning SM, Haynes BF, Waldmann TA, Kirsch IR
Proc Natl Acad Sci U S A. 1989
PubMed ID: 2602361
-
Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.
Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM
Proc Natl Acad Sci U S A. 1989
PubMed ID: 2740341
-
Response of BALB/c mice to leishmanial infection.
Blackwell JM, Roberts B, Alexander J
Curr Top Microbiol Immunol. 1985
PubMed ID: 3930154
Model Organism Phenotype Links
|
Relevant resources: