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STAT4

Gene Description:   signal transducer and activator of transcription 4 Synonyms:   SLEB11, STAT4, Stat4 Orthologs:   Human STAT4 (protein-coding), Mouse Stat4 (protein-coding), Rat Stat4 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, KEGG Human-Rat: HomoloGene, MGD, RGD, KEGG Mouse-Rat: HomoloGene, MGD, RGD, KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1 Rat: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
2q32.2	Human	chr2:191888224..192030553	0.14	6	rs6752770

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 2q32.2 Orthologous Region	Mouse	chr1:52053290..52167895	0.11	2
Human 2q32.2 Orthologous Region	Rat	chr9:46506510..46666202	0.16	2

(Human) GRCh37 - chr2:191894302..192016316 (1221 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr1:52043992..52164032 (1204 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr9:46455636..46650076 (194.44 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas                     no data   no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for STAT4: The STAT4 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs STAT4   CREBBP   HPRD  empirical  14660657  STAT4   MAPK14   HPRD  empirical  10961885  STAT4   ZNF467   HPRD  empirical  12426389  STAT4   IL12RB1   HPRD  empirical  10415122  STAT4   IL12RB2   HPRD  empirical  10415122  STAT4   JUN   HPRD  empirical  11801649  STAT4   MAP2K6   HPRD  empirical  10961885  STAT4   STAT3   HPRD  empirical  15522880  STAT4   STAT4   HPRD  empirical  14704793  STAT4   PIAS2   HPRD  empirical  12716907  STAT4   NMI   HPRD, IntAct  empirical  9989503

View all

KEGG Network: 1   Jak-STAT signaling pathway Human - 4630 Mouse - 4630 Rat - 4630

Biocarta: 2   IL12 and Stat4 Dependent Signaling Pathway in Th1 Development Human Mouse NO2-dependent IL 12 Pathway in NK cells Human Mouse

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: 5   IL23-mediated signaling events Downstream signaling in naïve CD8+ T cells IL27-mediated signaling events IL12 signaling mediated by STAT4 IL12-mediated signaling events

Gene Ontology: 13   Sequence-specific DNA binding transcription factor activity GO:0003700 Signal transducer activity GO:0004871 Calcium ion binding GO:0005509 Nucleus GO:0005634 Nucleolus GO:0005730 Cytoplasm GO:0005737 Transcription, DNA-dependent GO:0006351 Regulation of transcription, DNA-dependent GO:0006355 Protein phosphorylation GO:0006468 JAK-STAT cascade GO:0007259 Cell proliferation GO:0008283 Cytokine-mediated signaling pathway GO:0019221 Sequence-specific DNA binding GO:0043565

	KEGG Network: 1 Jak-STAT signaling pathway Human - 4630 Mouse - 4630 Rat - 4630
	Biocarta: 2 IL12 and Stat4 Dependent Signaling Pathway in Th1 Development Human Mouse NO2-dependent IL 12 Pathway in NK cells Human Mouse
	Reactome: None available
	NCI-Nature Pathway Interaction Database: 5 IL23-mediated signaling events Downstream signaling in naïve CD8+ T cells IL27-mediated signaling events IL12 signaling mediated by STAT4 IL12-mediated signaling events
	Gene Ontology: 13 Sequence-specific DNA binding transcription factor activity GO:0003700 Signal transducer activity GO:0004871 Calcium ion binding GO:0005509 Nucleus GO:0005634 Nucleolus GO:0005730 Cytoplasm GO:0005737 Transcription, DNA-dependent GO:0006351 Regulation of transcription, DNA-dependent GO:0006355 Protein phosphorylation GO:0006468 JAK-STAT cascade GO:0007259 Cell proliferation GO:0008283 Cytokine-mediated signaling pathway GO:0019221 Sequence-specific DNA binding GO:0043565

Type 1 Diabetes Publications: 11

• A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.
  Budarf ML, Goyette P, Boucher G, Lian J, Graham RR, Claudio JO, Hudson T, Gladman D, Clarke AE, Pope JE, Peschken C, Smith CD, Hanly J, Rich E, Boire G, Barr SG, Zummer M, GenES Investigators, Fortin PR, Wither J, Rioux JD
  Genes Immun. 2010
  PubMed ID: 20962850
   
  
• STAT4 gene polymorphism is associated with psoriasis in the genetically homogeneous population of Crete, Greece.
  Zervou MI, Goulielmos GN, Castro-Giner F, Tosca AD, Krueger-Krasagakis S
  Hum Immunol. 2009
  PubMed ID: 19500629
   
  
• STAT4 is not associated with type 2 diabetes in the genetically homogeneous population of Crete.
  Kofteridis D, Krasoudaki E, Kavousanaki M, Zervou MI, Panierakis C, Boumpas DT, Goulielmos GN
  Genet Test Mol Biomarkers. 2009
  PubMed ID: 19371230
   
  
• Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.
  Fung EY, Smyth DJ, Howson JM, Cooper JD, Walker NM, Stevens H, Wicker LS, Todd JA
  Genes Immun. 2009
  PubMed ID: 19110536
   
  
• STAT4 polymorphism is associated with early-onset type 1 diabetes, but not with late-onset type 1 diabetes.
  Lee HS, Park H, Yang S, Kim D, Park Y
  Ann N Y Acad Sci. 2008
  PubMed ID: 19120275
   
  
• Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases.
  Martínez A, Varadé J, Márquez A, Cénit MC, Espino L, Perdigones N, Santiago JL, Fernández-Arquero M, de la Calle H, Arroyo R, Mendoza JL, Fernández-Gutiérrez B, de la Concha EG, Urcelay E
  Arthritis Rheum. 2008
  PubMed ID: 18759272
   
  
• STAT4: A risk factor for type 1 diabetes?
  Zervou MI, Mamoulakis D, Panierakis C, Boumpas DT, Goulielmos GN
  Hum Immunol. 2008
  PubMed ID: 18703106
   
  
• Stat4-null non-obese diabetic mice: protection from diabetes and experimental allergic encephalomyelitis, but with concomitant epitope spread.
  Boyton RJ, Davies S, Marden C, Fantino C, Reynolds C, Portugal K, Dewchand H, Altmann DM
  Int Immunol. 2005
  PubMed ID: 16027138
   
  
• Effect of targeted disruption of signal transducer and activator of transcription (Stat)4 and Stat6 genes on the autoimmune diabetes development induced by multiple low doses of streptozotocin.
  Cetkovic-Cvrlje M, Uckun FM
  Clin Immunol. 2005
  PubMed ID: 15721841
   
  
• Autoimmune diabetes is blocked in Stat4-deficient mice.
  Yang Z, Chen M, Ellett JD, Fialkow LB, Carter JD, McDuffie M, Nadler JL
  J Autoimmun. 2004
  PubMed ID: 15041039
   
  
• Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence.
  Holz A, Bot A, Coon B, Wolfe T, Grusby MJ, von Herrath MG
  J Immunol. 1999
  PubMed ID: 10553062
   
  

Publications: 327

• Signal transducer and activator of transcription 4 gene polymorphisms associated with rheumatoid arthritis in Northwestern Chinese Han population.
  Liang YL, Wu H, Li PQ, Xie XD, Shen X, Yang XQ, Cheng X, Liang L
  Life Sci. 2011
  PubMed ID: 21683716
   
  
• Interleukin-12 treatment down-regulates STAT4 and induces apoptosis with increasing ROS production in human natural killer cells.
  Huang Y, Lei Y, Zhang H, Zhang M, Dayton A
  J Leukoc Biol. 2011
  PubMed ID: 21543583
   
  
• Stat4 is critical for the balance between Th17 cells and regulatory T cells in colitis.
  Xu J, Yang Y, Qiu G, Lal G, Yin N, Wu Z, Bromberg JS, Ding Y
  J Immunol. 2011
  PubMed ID: 21525389
   
  
• Polymorphisms in STAT4 increase the risk of acute renal allograft rejection in the Chinese population.
  Yang H, Zhou Q, Chen ZM, Chen WQ, Wang MM, Chen JH
  Transpl Immunol. 2011
  PubMed ID: 21237270
   
  
• Chronic effects of single and fractionated γ-irradiation on an impairment of Th1-related immune response.
  Park HR, Jo SK, Eom HS
  Int J Radiat Biol. 2011
  PubMed ID: 21219110
   
  
• Signal transducer and activator of transcription and the risk of rheumatoid arthritis and thyroid autoimmune disorders.
  Ben Hamad M, Cornelis F, Mbarek H, Chabchoub G, Marzouk S, Bahloul Z, Rebai A, Fakhfakh F, Ayadi H, Petit-Teixeira E, Maalej A
  Clin Exp Rheumatol. 2011
  PubMed ID: 21418779
   
  
• Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
  Chung SA, Taylor KE, Graham RR, Nititham J, Lee AT, Ortmann WA, Jacob CO, Alarcón-Riquelme ME, Tsao BP, Harley JB, Gaffney PM, Moser KL, SLEGEN, Petri M, Demirci FY, Kamboh MI, Manzi S, Gregersen PK, Langefeld CD, Behrens TW, Criswell LA
  PLoS Genet. 2011
  PubMed ID: 21408207
   
  
• Association of genetic variations in the STAT4 and IRF7/KIAA1542 regions with systemic lupus erythematosus in a Northern Han Chinese population.
  Li P, Cao C, Luan H, Li C, Hu C, Zhang S, Zeng X, Zhang F, Zeng C, Li Y
  Hum Immunol. 2011
  PubMed ID: 21167895
   
  
• Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
  Zhernakova A, Stahl EA, Trynka G, Raychaudhuri S, Festen EA, Franke L, Westra HJ, Fehrmann RS, Kurreeman FA, Thomson B, Gupta N, Romanos J, McManus R, Ryan AW, Turner G, Brouwer E, Posthumus MD, Remmers EF, Tucci F, Toes R, Grandone E, Mazzilli MC, Rybak A, Cukrowska B, Coenen MJ, Radstake TR, van Riel PL, Li Y, de Bakker PI, Gregersen PK, Worthington J, Siminovitch KA, Klareskog L, Huizinga TW, Wijmenga C, Plenge RM
  PLoS Genet. 2011
  PubMed ID: 21383967
   
  
• Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice.
  Wüthrich M, Gern B, Hung CY, Ersland K, Rocco N, Pick-Jacobs J, Galles K, Filutowicz H, Warner T, Evans M, Cole G, Klein B
  J Clin Invest. 2011
  PubMed ID: 21206087
   
  
• Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice.
  Menke J, Bork T, Kutska B, Byrne KT, Blanfeld M, Relle M, Kelley VR, Schwarting A
  Kidney Int. 2011
  PubMed ID: 20980973
   
  
• STAT4 is required for IFN-β-induced MCP-1 mRNA expression in murine mast cells.
  Iida K, Suzuki K, Yokota M, Nakagomi D, Wakashin H, Iwata A, Kawashima H, Takatori H, Nakajima H
  Int Arch Allergy Immunol. 2011
  PubMed ID: 21646799
   
  
• Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
  Mells GF, Floyd JA, Morley KI, Cordell HJ, Franklin CS, Shin SY, Heneghan MA, Neuberger JM, Donaldson PT, Day DB, Ducker SJ, Muriithi AW, Wheater EF, Hammond CJ, Dawwas MF, UK PBC Consortium, Wellcome Trust Case Control Consortium 3, Jones DE, Peltonen L, Alexander GJ, Sandford RN, Anderson CA
  Nat Genet. 2011
  PubMed ID: 21399635
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Attenuated expression of tenascin-C in ovalbumin-challenged STAT4-/- mice.
  Meuronen A, Karisola P, Leino M, Savinko T, Sirola K, Majuri ML, Piirilä P, Virtanen I, Mäkelä M, Laitinen A, Laitinen LA, Alenius H
  Respir Res. 2011
  PubMed ID: 21205293
   
  
• Genetically determined amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus.
  Sanchez E, Webb RD, Rasmussen A, Kelly JA, Riba L, Kaufman KM, Garcia-de la Torre I, Moctezuma JF, Maradiaga-Ceceña MA, Cardiel-Rios MH, Acevedo E, Cucho-Venegas M, Garcia MA, Gamron S, Pons-Estel BA, Vasconcelos C, Martin J, Tusié-Luna T, Harley JB, Richardson B, Sawalha AH, Alarcón-Riquelme ME
  Arthritis Rheum. 2010
  PubMed ID: 20848568
   
  
• Variation in STAT4 is associated with systemic lupus erythematosus in Chinese Northern Han population.
  Su Y, Zhao Y, Liu X, Guo JP, Jiang Q, Liu XY, Zhang FC, Zheng Y, Li XX, Song H, Huang CB, Huang YH, Wang T, Pan SS, Li C, Liu X, Zhu L, Zhang CF, Li ZG
  Chin Med J (Engl). 2010
  PubMed ID: 21163111
   
  
• Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans.
  Hughes LB, Reynolds RJ, Brown EE, Kelley JM, Thomson B, Conn DL, Jonas BL, Westfall AO, Padilla MA, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Plenge RM, Bridges SL
  Arthritis Rheum. 2010
  PubMed ID: 20973039
   
  
• Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients.
  Webb R, Kelly JA, Somers EC, Hughes T, Kaufman KM, Sanchez E, Nath SK, Bruner G, Alarcón-Riquelme ME, Gilkeson GS, Kamen DL, Richardson BC, Harley JB, Sawalha AH
  Ann Rheum Dis. 2010
  PubMed ID: 20881011
   
  
• Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome.
  Nordmark G, Kristjansdottir G, Theander E, Appel S, Eriksson P, Vasaitis L, Kvarnström M, Delaleu N, Lundmark P, Lundmark A, Sjöwall C, Brun JG, Jonsson MV, Harboe E, Gøransson LG, Johnsen SJ, Söderkvist P, Eloranta ML, Alm G, Baecklund E, Wahren-Herlenius M, Omdal R, Rönnblom L, Jonsson R, Syvänen AC
  Genes Immun. 2010
  PubMed ID: 20861858
   
  
• N-ethyl-N-nitrosourea-induced mutation in ubiquitin-specific peptidase 18 causes hyperactivation of IFN-αß signaling and suppresses STAT4-induced IFN-γ production, resulting in increased susceptibility to Salmonella typhimurium.
  Richer E, Prendergast C, Zhang DE, Qureshi ST, Vidal SM, Malo D
  J Immunol. 2010
  PubMed ID: 20693420
   
  
• Lack of association of PTPN22, STAT4 and TRAF1/C5 gene polymorphisms with cardiovascular risk in rheumatoid arthritis.
  Palomino-Morales R, Gonzalez-Juanatey C, Vazquez-Rodriguez TR, Rodriguez L, Miranda-Filloy JA, Pascual-Salcedo D, Balsa A, Fernandez-Gutierrez B, Llorca J, Martin J, Gonzalez-Gay MA
  Clin Exp Rheumatol. 2010
  PubMed ID: 20822712
   
  
• Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.
  Chang JS, Wiemels JL, Chokkalingam AP, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Green J, May SL, Kiley VA, Wiencke JK, Buffler PA
  Cancer Epidemiol Biomarkers Prev. 2010
  PubMed ID: 20716621
   
  
• Regulation of mouse spermatogonial stem cell differentiation by STAT3 signaling.
  Oatley JM, Kaucher AV, Avarbock MR, Brinster RL
  Biol Reprod. 2010
  PubMed ID: 20505165
   
  
• Genetic variants in the prediction of rheumatoid arthritis.
  van der Helm-van Mil AH, Toes RE, Huizinga TW
  Ann Rheum Dis. 2010
  PubMed ID: 20439292
   
  
• IL-12-STAT4-IFN-gamma axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model.
  Kim YS, Choi SJ, Choi JP, Jeon SG, Oh SY, Lee BJ, Gho YS, Lee CG, Zhu Z, Elias JA, Kim YK
  Exp Mol Med. 2010
  PubMed ID: 20592486
   
  
• Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1.
  Sundqvist J, Falconer H, Seddighzadeh M, Vodolazkaia A, Fassbender A, Kyama C, Bokor A, Stephansson O, Padyukov L, Gemzell-Danielsson K, D'Hooghe TM
  Fertil Steril. 2010
  PubMed ID: 20797713
   
  
• Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype.
  Yeh N, Glosson NL, Wang N, Guindon L, McKinley C, Hamada H, Li Q, Dutton RW, Shrikant P, Zhou B, Brutkiewicz RR, Blum JS, Kaplan MH
  J Immunol. 2010
  PubMed ID: 20624947
   
  
• Distal regions of the human IFNG locus direct cell type-specific expression.
  Collins PL, Chang S, Henderson M, Soutto M, Davis GM, McLoed AG, Townsend MJ, Glimcher LH, Mortlock DP, Aune TM
  J Immunol. 2010
  PubMed ID: 20574006
   
  
• Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers.
  Plant D, Flynn E, Mbarek H, Dieudé P, Cornelis F, Arlestig L, Dahlqvist SR, Goulielmos G, Boumpas DT, Sidiropoulos P, Johansen JS, Ørnbjerg LM, Hetland ML, Klareskog L, Filer A, Buckley CD, Raza K, Witte T, Schmidt RE, Worthington J
  Ann Rheum Dis. 2010
  PubMed ID: 20498205
   
  
• Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli.
  Balasubramani A, Shibata Y, Crawford GE, Baldwin AS, Hatton RD, Weaver CT
  Immunity. 2010
  PubMed ID: 20643337
   
  
• STAT4 is a confirmed genetic risk factor for Sjögren's syndrome and could be involved in type 1 interferon pathway signaling.
  Gestermann N, Mekinian A, Comets E, Loiseau P, Puechal X, Hachulla E, Gottenberg JE, Mariette X, Miceli-Richard C
  Genes Immun. 2010
  PubMed ID: 20535138
   
  
• STAT4 polymorphism in a Chinese Han population with Vogt-Koyanagi-Harada syndrome and Behçet's disease.
  Hu K, Yang P, Jiang Z, Hou S, Du L, Li F
  Hum Immunol. 2010
  PubMed ID: 20438790
   
  
• Polymorphisms in innate immunity genes and risk of childhood leukemia.
  Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D
  Hum Immunol. 2010
  PubMed ID: 20438785
   
  
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
  Mol Med. 2010
  PubMed ID: 20379614
   
  
• Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation.
  Wei L, Vahedi G, Sun HW, Watford WT, Takatori H, Ramos HL, Takahashi H, Liang J, Gutierrez-Cruz G, Zang C, Peng W, O'Shea JJ, Kanno Y
  Immunity. 2010
  PubMed ID: 20620946
   
  
• Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
  Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R
  Pediatr Pulmonol. 2010
  PubMed ID: 20503287
   
  
• Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
  Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FA, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Brouwer E, Burtt NP, Catanese JJ, Coblyn J, Coenen MJ, Costenbader KH, Criswell LA, Crusius JB, Cui J, de Bakker PI, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Lee AT, Liu X, Martin P, Morgan AW, Padyukov L, Posthumus MD, Radstake TR, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, van der Schoot CE, van Riel PL, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth BP, YEAR Consortium, Wijmenga C, Karlson EW, Toes RE, de Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM
  Nat Genet. 2010
  PubMed ID: 20453842
   
  
• A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
  Kochi Y, Okada Y, Suzuki A, Ikari K, Terao C, Takahashi A, Yamazaki K, Hosono N, Myouzen K, Tsunoda T, Kamatani N, Furuichi T, Ikegawa S, Ohmura K, Mimori T, Matsuda F, Iwamoto T, Momohara S, Yamanaka H, Yamada R, Kubo M, Nakamura Y, Yamamoto K
  Nat Genet. 2010
  PubMed ID: 20453841
   
  
• Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.
  Tan RJ, Gibbons LJ, Potter C, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, BRAGGSS, Barton A
  Ann Rheum Dis. 2010
  PubMed ID: 20444755
   
  
• Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage.
  Mukasa R, Balasubramani A, Lee YK, Whitley SK, Weaver BT, Shibata Y, Crawford GE, Hatton RD, Weaver CT
  Immunity. 2010
  PubMed ID: 20471290
   
  
• Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.
  Hinks A, Eyre S, Ke X, Barton A, Martin P, Flynn E, Packham J, Childhood Arthritis Prospective Study (CAPS), UKRAG Consortium, BSPAR Study Group, Worthington J, Thomson W
  Ann Rheum Dis. 2010
  PubMed ID: 19674979
   
  
• Risk of meningioma and common variation in genes related to innate immunity.
  Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD
  Cancer Epidemiol Biomarkers Prev. 2010
  PubMed ID: 20406964
   
  
• Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.
  Radstake TR, Gorlova O, Rueda B, Martin JE, Alizadeh BZ, Palomino-Morales R, Coenen MJ, Vonk MC, Voskuyl AE, Schuerwegh AJ, Broen JC, van Riel PL, van 't Slot R, Italiaander A, Ophoff RA, Riemekasten G, Hunzelmann N, Simeon CP, Ortego-Centeno N, González-Gay MA, González-Escribano MF, Spanish Scleroderma Group, Airo P, van Laar J, Herrick A, Worthington J, Hesselstrand R, Smith V, de Keyser F, Houssiau F, Chee MM, Madhok R, Shiels P, Westhovens R, Kreuter A, Kiener H, de Baere E, Witte T, Padykov L, Klareskog L, Beretta L, Scorza R, Lie BA, Hoffmann-Vold AM, Carreira P, Varga J, Hinchcliff M, Gregersen PK, Lee AT, Ying J, Han Y, Weng SF, Amos CI, Wigley FM, Hummers L, Nelson JL, Agarwal SK, Assassi S, Gourh P, Tan FK, Koeleman BP, Arnett FC, Martin J, Mayes MD
  Nat Genet. 2010
  PubMed ID: 20383147
   
  
• Influence of STAT4 polymorphism in primary Sjögren's syndrome.
  Palomino-Morales RJ, Diaz-Gallo LM, Witte T, Anaya JM, Martín J
  J Rheumatol. 2010
  PubMed ID: 20360187
   
  
• STAT4 gene influences genetic predisposition to ulcerative colitis but not Crohn's disease in the Spanish population: a replication study.
  Diaz-Gallo LM, Palomino-Morales RJ, Gómez-García M, Cardeña C, Rodrigo L, Nieto A, Alcain G, Cueto I, López-Nevot MA, Martin J
  Hum Immunol. 2010
  PubMed ID: 20153791
   
  
• A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus.
  Svenungsson E, Gustafsson J, Leonard D, Sandling J, Gunnarsson I, Nordmark G, Jönsen A, Bengtsson AA, Sturfelt G, Rantapää-Dahlqvist S, Elvin K, Sundin U, Garnier S, Simard JF, Sigurdsson S, Padyukov L, Syvänen AC, Rönnblom L
  Ann Rheum Dis. 2010
  PubMed ID: 19762360
   
  
• Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease.
  Moon CM, Cheon JH, Kim SW, Shin DJ, Kim ES, Shin ES, Kang Y, Park JJ, Hong SP, Nam SY, Kim TI, Kim WH
  Life Sci. 2010
  PubMed ID: 20176035
   
  
• Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
  Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
  Dev Cell. 2010
  PubMed ID: 20412781
   
  
• New genetic associations detected in a host response study to hepatitis B vaccine.
  Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
  Genes Immun. 2010
  PubMed ID: 20237496
   
  
• Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans.
  Kelley JM, Hughes LB, Malik A, Danila MI, Edberg Y, Alarcón GS, Conn DL, Jonas BL, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Bridges SL
  Ann Rheum Dis. 2010
  PubMed ID: 20237121
   
  
• IRF5 is associated with primary antiphospholipid syndrome, but is not a major risk factor.
  Fredi M, Tincani A, Yin H, Delgado-Vega AM, Borghi MO, Meroni PL, Alarcón-Riquelme ME
  Arthritis Rheum. 2010
  PubMed ID: 20131273
   
  
• A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis.
  Wieczorek S, Holle JU, Müller S, Fricke H, Gross WL, Epplen JT
  J Mol Med. 2010
  PubMed ID: 20049410
   
  
• Polymorphisms of signal transducers and activators of transcription 1 and 4 (STAT1 and STAT4) contribute to progression of childhood IgA nephropathy.
  Hahn WH, Suh JS, Cho SH, Cho BS, Kim SD
  Cytokine. 2010
  PubMed ID: 20045654
   
  
• Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.
  Karlson EW, Chibnik LB, Kraft P, Cui J, Keenan BT, Ding B, Raychaudhuri S, Klareskog L, Alfredsson L, Plenge RM
  Ann Rheum Dis. 2010
  PubMed ID: 20233754
   
  
• The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register.
  Plant D, Thomson W, Lunt M, Flynn E, Martin P, Eyre S, Farragher T, Bunn D, Worthington J, Symmons D, Barton A
  Rheumatology (Oxford). 2010
  PubMed ID: 20219786
   
  
• T-bet, a Th1 transcription factor regulates the expression of Tim-3.
  Anderson AC, Lord GM, Dardalhon V, Lee DH, Sabatos-Peyton CA, Glimcher LH, Kuchroo VK
  Eur J Immunol. 2010
  PubMed ID: 20049876
   
  
• A meta-analysis of the association of STAT4 polymorphism with systemic lupus erythematosus.
  Yuan H, Feng JB, Pan HF, Qiu LX, Li LH, Zhang N, Ye DQ
  Mod Rheumatol. 2010
  PubMed ID: 20169389
   
  
• Type I IFN controls chikungunya virus via its action on nonhematopoietic cells.
  Schilte C, Couderc T, Chretien F, Sourisseau M, Gangneux N, Guivel-Benhassine F, Kraxner A, Tschopp J, Higgs S, Michault A, Arenzana-Seisdedos F, Colonna M, Peduto L, Schwartz O, Lecuit M, Albert ML
  J Exp Med. 2010
  PubMed ID: 20123960
   
  
• Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.
  Vuong MT, Gunnarsson I, Lundberg S, Svenungsson E, Wramner L, Fernström A, Syvänen AC, Do LT, Jacobson SH, Padyukov L
  PLoS One. 2010
  PubMed ID: 20479942
   
  
• Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
  Glas J, Seiderer J, Nagy M, Fries C, Beigel F, Weidinger M, Pfennig S, Klein W, Epplen JT, Lohse P, Folwaczny M, Göke B, Ochsenkühn T, Diegelmann J, Müller-Myhsok B, Roeske D, Brand S
  PLoS One. 2010
  PubMed ID: 20454450
   
  
• Association of IRF5, STAT4 and BLK with systemic lupus erythematosus and other rheumatic diseases.
  Tsuchiya N, Ito I, Kawasaki A
  Nihon Rinsho Meneki Gakkai Kaishi. 2010
  PubMed ID: 20453440
   
  
• Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort.
  Morgan AW, Robinson JI, Conaghan PG, Martin SG, Hensor EM, Morgan MD, Steiner L, Erlich HA, Gooi HC, Barton A, Worthington J, Emery P, UKRAG Consortium, YEAR Consortium
  Arthritis Res Ther. 2010
  PubMed ID: 20353580
   
  
• Loss of Jak2 selectively suppresses DC-mediated innate immune response and protects mice from lethal dose of LPS-induced septic shock.
  Zhong J, Yang P, Muta K, Dong R, Marrero M, Gong F, Wang CY
  PLoS One. 2010
  PubMed ID: 20231889
   
  
• Involvement of STAT4 in IgG subtype switching and ocular HSV-1 replication in mice.
  Allen SJ, Mott KR, Ghiasi H
  Mol Vis. 2010
  PubMed ID: 20104254
   
  
• A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
  Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
  Dev Cell. 2009
  PubMed ID: 20059953
   
  
• Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines.
  Gourh P, Agarwal SK, Divecha D, Assassi S, Paz G, Arora-Singh RK, Reveille JD, Shete S, Mayes MD, Arnett FC, Tan FK
  Arthritis Rheum. 2009
  PubMed ID: 19950257
   
  
• BANK1 is a genetic risk factor for diffuse cutaneous systemic sclerosis and has additive effects with IRF5 and STAT4.
  Dieudé P, Wipff J, Guedj M, Ruiz B, Melchers I, Hachulla E, Riemekasten G, Diot E, Hunzelmann N, Sibilia J, Tiev K, Mouthon L, Cracowski JL, Carpentier PH, Distler J, Amoura Z, Tarner I, Avouac J, Meyer O, Kahan A, Boileau C, Allanore Y
  Arthritis Rheum. 2009
  PubMed ID: 19877059
   
  
• Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
  Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, Xu JH, Cai ZM, Huang W, Zhao GP, Xie HF, Fang H, Lu QJ, Xu JH, Li XP, Pan YF, Deng DQ, Zeng FQ, Ye ZZ, Zhang XY, Wang QW, Hao F, Ma L, Zuo XB, Zhou FS, Du WH, Cheng YL, Yang JQ, Shen SK, Li J, Sheng YJ, Zuo XX, Zhu WF, Gao F, Zhang PL, Guo Q, Li B, Gao M, Xiao FL, Quan C, Zhang C, Zhang Z, Zhu KJ, Li Y, Hu DY, Lu WS, Huang JL, Liu SX, Li H, Ren YQ, Wang ZX, Yang CJ, Wang PG, Zhou WM, Lv YM, Zhang AP, Zhang SQ, Lin D, Li Y, Low HQ, Shen M, Zhai ZF, Wang Y, Zhang FY, Yang S, Liu JJ, Zhang XJ
  Nat Genet. 2009
  PubMed ID: 19838193
   
  
• Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci.
  McClure A, Lunt M, Eyre S, Ke X, Thomson W, Hinks A, Bowes J, Gibbons L, Plant D, Wilson AG, Marinou I, Morgan AW, Emery P, BIRAC consortium, Steer S, Hocking LJ, Reid DM, Wordsworth P, Harrison P, Worthington J, Barton A
  Rheumatology (Oxford). 2009
  PubMed ID: 19741008
   
  
• A haplotype in STAT4 gene associated with rheumatoid arthritis in Caucasians is not associated in the Han Chinese population, but with the presence of rheumatoid factor.
  Li H, Zou Q, Xie Z, Liu Y, Zhong B, Yang S, Zheng P, Yang F, Fang Y, Wu Y
  Rheumatology (Oxford). 2009
  PubMed ID: 19737838
   
  
• Epigenetic regulation of the alternatively activated macrophage phenotype.
  Ishii M, Wen H, Corsa CA, Liu T, Coelho AL, Allen RM, Carson WF, Cavassani KA, Li X, Lukacs NW, Hogaboam CM, Dou Y, Kunkel SL
  Blood. 2009
  PubMed ID: 19567879
   
  
• A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome.
  Ranatunga D, Hedrich CM, Wang F, McVicar DW, Nowak N, Joshi T, Feigenbaum L, Grant LR, Stäger S, Bream JH
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19805095
   
  
• Cigarette smoking, STAT4 and TNFRSF1B polymorphisms, and systemic lupus erythematosus in a Japanese population.
  Kiyohara C, Washio M, Horiuchi T, Tada Y, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H, Kyushu Sapporo SLE (KYSS) Study Group
  J Rheumatol. 2009
  PubMed ID: 19684152
   
  
• Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming.
  Good SR, Thieu VT, Mathur AN, Yu Q, Stritesky GL, Yeh N, O'Malley JT, Perumal NB, Kaplan MH
  J Immunol. 2009
  PubMed ID: 19710469
   
  
• Variation in STAT4 is associated with systemic lupus erythematosus (SLE) in a Finnish family cohort.
  Hellquist A, Sandling JK, Zucchelli M, Koskenmies S, Julkunen H, D'Amato M, Garnier S, Syvänen AC, Kere J
  Ann Rheum Dis. 2009
  PubMed ID: 19717398
   
  
• Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose.
  Saraiva M, Christensen JR, Veldhoen M, Murphy TL, Murphy KM, O'Garra A
  Immunity. 2009
  PubMed ID: 19646904
   
  
• IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells.
  Guo L, Wei G, Zhu J, Liao W, Leonard WJ, Zhao K, Paul W
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19666510
   
  
• STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis.
  Dieudé P, Guedj M, Wipff J, Ruiz B, Hachulla E, Diot E, Granel B, Sibilia J, Tiev K, Mouthon L, Cracowski JL, Carpentier PH, Amoura Z, Fajardy I, Avouac J, Meyer O, Kahan A, Boileau C, Allanore Y
  Arthritis Rheum. 2009
  PubMed ID: 19644887
   
  
• Association of STAT4 and BLK, but not BANK1 or IRF5, with primary antiphospholipid syndrome.
  Yin H, Borghi MO, Delgado-Vega AM, Tincani A, Meroni PL, Alarcón-Riquelme ME
  Arthritis Rheum. 2009
  PubMed ID: 19644876
   
  
• Association of STAT4 polymorphism with systemic sclerosis in a Japanese population.
  Tsuchiya N, Kawasaki A, Hasegawa M, Fujimoto M, Takehara K, Kawaguchi Y, Kawamoto M, Hara M, Sato S
  Ann Rheum Dis. 2009
  PubMed ID: 19605749
   
  
• STAT4 single nucleotide polymorphism, rs7574865 G/T, as a risk for antiphospholipid syndrome.
  Horita T, Atsumi T, Yoshida N, Nakagawa H, Kataoka H, Yasuda S, Koike T
  Ann Rheum Dis. 2009
  PubMed ID: 19605742
   
  
• Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells.
  O'Malley JT, Sehra S, Thieu VT, Yu Q, Chang HC, Stritesky GL, Nguyen ET, Mathur AN, Levy DE, Kaplan MH
  Immunology. 2009
  PubMed ID: 19604309
   
  
• Association between the rs7574865 polymorphism of STAT4 and rheumatoid arthritis: a meta-analysis.
  Lee YH, Woo JH, Choi SJ, Ji JD, Song GG
  Rheumatol Int. 2009
  PubMed ID: 19588142
   
  
• Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis.
  Prahalad S, Hansen S, Whiting A, Guthery SL, Clifford B, McNally B, Zeft AS, Bohnsack JF, Jorde LB
  Arthritis Rheum. 2009
  PubMed ID: 19565500
   
  
• Impaired development of human Th1 cells in patients with deficient expression of STAT4.
  Chang HC, Han L, Goswami R, Nguyen ET, Pelloso D, Robertson MJ, Kaplan MH
  Blood. 2009
  PubMed ID: 19359411
   
  
• The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype.
  Rueda B, Broen J, Simeon C, Hesselstrand R, Diaz B, Suárez H, Ortego-Centeno N, Riemekasten G, Fonollosa V, Vonk MC, van den Hoogen FH, Sanchez-Román J, Aguirre-Zamorano MA, García-Portales R, Pros A, Camps MT, Gonzalez-Gay MA, Coenen MJ, Airo P, Beretta L, Scorza R, van Laar J, Gonzalez-Escribano MF, Nelson JL, Radstake TR, Martin J
  Hum Mol Genet. 2009
  PubMed ID: 19286670
   
  
• Association of STAT4 polymorphism with rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis.
  Ji JD, Lee WJ, Kong KA, Woo JH, Choi SJ, Lee YH, Song GG
  Mol Biol Rep. 2009
  PubMed ID: 19479340
   
  
• STAT6 inhibits T-bet-independent Th1 cell differentiation.
  Tamachi T, Takatori H, Fujiwara M, Hirose K, Maezawa Y, Kagami S, Suto A, Watanabe N, Iwamoto I, Nakajima H
  Biochem Biophys Res Commun. 2009
  PubMed ID: 19324016
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• Common variation in genes related to innate immunity and risk of adult glioma.
  Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ
  Cancer Epidemiol Biomarkers Prev. 2009
  PubMed ID: 19423540
   
  
• Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis.
  Daha NA, Kurreeman FA, Marques RB, Stoeken-Rijsbergen G, Verduijn W, Huizinga TW, Toes RE
  Arthritis Rheum. 2009
  PubMed ID: 19404967
   
  
• IL-23 drives pathogenic IL-17-producing CD8+ T cells.
  Ciric B, El-behi M, Cabrera R, Zhang GX, Rostami A
  J Immunol. 2009
  PubMed ID: 19380776
   
  
• CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis.
  Zhang S, Bernard D, Khan WI, Kaplan MH, Bramson JL, Wan Y
  Eur J Immunol. 2009
  PubMed ID: 19338001
   
  
• Lack of association between STAT4 gene polymorphism and biopsy-proven giant cell arteritis.
  Palomino-Morales R, Vazquez-Rodriguez TR, Morado IC, Castañeda S, Ortego-Centeno N, Miranda-Filloy JA, Lamas JR, Martin J, Gonzalez-Gay MA
  J Rheumatol. 2009
  PubMed ID: 19332627
   
  
• Association of single-nucleotide polymorphisms in JAK3, STAT4, and STAT6 with new cardiovascular events in incident dialysis patients.
  Sperati CJ, Parekh RS, Berthier-Schaad Y, Jaar BG, Plantinga L, Fink N, Powe NR, Smith MW, Coresh J, Kao WH
  Am J Kidney Dis. 2009
  PubMed ID: 19282076
   
  
• The Current STATus of lymphocyte signaling: new roles for old players.
  Adamson AS, Collins K, Laurence A, O'Shea JJ
  Curr Opin Immunol. 2009
  PubMed ID: 19362457
   
  
• High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.
  Namjou B, Sestak AL, Armstrong DL, Zidovetzki R, Kelly JA, Jacob N, Ciobanu V, Kaufman KM, Ojwang JO, Ziegler J, Quismorio FP, Reiff A, Myones BL, Guthridge JM, Nath SK, Bruner GR, Mehrian-Shai R, Silverman E, Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Nocton JJ, Putterman C, Bae SC, Kim YJ, Petri M, Reveille JD, Vyse TJ, Gilkeson GS, Kamen DL, Alarcón-Riquelme ME, Gaffney PM, Moser KL, Merrill JT, Scofield RH, James JA, Langefeld CD, Harley JB, Jacob CO
  Arthritis Rheum. 2009
  PubMed ID: 19333953
   
  
• Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
  Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
  Pediatr Infect Dis J. 2009
  PubMed ID: 19258923
   
  
• Beta-glycoglycosphingolipid-induced alterations of the STAT signaling pathways are dependent on CD1d and the lipid raft protein flotillin-2.
  Lalazar G, Ben Ya'acov A, Livovsky DM, El Haj M, Pappo O, Preston S, Zolotarov L, Ilan Y
  Am J Pathol. 2009
  PubMed ID: 19246642
   
  
• Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese.
  Yang W, Ng P, Zhao M, Hirankarn N, Lau CS, Mok CC, Chan TM, Wong RW, Lee KW, Mok MY, Wong SN, Avihingsanon Y, Lee TL, Ho MH, Lee PP, Wong WH, Lau YL
  Genes Immun. 2009
  PubMed ID: 19225526
   
  
• Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities.
  Eddahri F, Denanglaire S, Bureau F, Spolski R, Leonard WJ, Leo O, Andris F
  Blood. 2009
  PubMed ID: 19020307
   
  
• MOG(35-55) i.v suppresses experimental autoimmune encephalomyelitis partially through modulation of Th17 and JAK/STAT pathways.
  Jiang Z, Li H, Fitzgerald DC, Zhang GX, Rostami A
  Eur J Immunol. 2009
  PubMed ID: 19224632
   
  
• Signal transducer and activation of transcription (STAT) 4beta, a shorter isoform of interleukin-12-induced STAT4, is preferentially activated by estrogen.
  Karpuzoglu E, Phillips RA, Dai R, Graniello C, Gogal RM, Ahmed SA
  Endocrinology. 2009
  PubMed ID: 18988675
   
  
• Late developmental plasticity in the T helper 17 lineage.
  Lee YK, Turner H, Maynard CL, Oliver JR, Chen D, Elson CO, Weaver CT
  Immunity. 2009
  PubMed ID: 19119024
   
  
• Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.
  Kariuki SN, Kirou KA, MacDermott EJ, Barillas-Arias L, Crow MK, Niewold TB
  J Immunol. 2009
  PubMed ID: 19109131
   
  
• Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome.
  Nordmark G, Kristjansdottir G, Theander E, Eriksson P, Brun JG, Wang C, Padyukov L, Truedsson L, Alm G, Eloranta ML, Jonsson R, Rönnblom L, Syvänen AC
  Genes Immun. 2009
  PubMed ID: 19092842
   
  
• T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation.
  Chang S, Collins PL, Aune TM
  J Immunol. 2008
  PubMed ID: 19050254
   
  
• STAT4 Associates with SLE through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk.
  Abelson AK, Delgado-Vega AM, Kozyrev SV, Sánchez E, Velázquez-Cruz R, Eriksson N, Wojcik J, Linga Reddy P, Lima G, D'Alfonso S, Migliaresi S, Baca V, Orozco L, Witte T, Ortego-Centeno N, Abderrahim H, Pons-Estel BA, Gutiérrez C, Suárez A, González-Escribano MF, Martin J, Alarcón-Riquelme ME
  Ann Rheum Dis. 2008
  PubMed ID: 19019891
   
  
• Graft rejection as a Th1-type process amenable to regulation by donor Th2-type cells through an interleukin-4/STAT6 pathway.
  Mariotti J, Foley J, Ryan K, Buxhoeveden N, Kapoor V, Amarnath S, Fowler DH
  Blood. 2008
  PubMed ID: 18625883
   
  
• Cutting edge: Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced disease.
  Castilow EM, Legge KL, Varga SM
  J Immunol. 2008
  PubMed ID: 18981084
   
  
• Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination.
  Thieu VT, Yu Q, Chang HC, Yeh N, Nguyen ET, Sehra S, Kaplan MH
  Immunity. 2008
  PubMed ID: 18993086
   
  
• Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis.
  Mo C, Chearwae W, O'Malley JT, Adams SM, Kanakasabai S, Walline CC, Stritesky GL, Good SR, Perumal NB, Kaplan MH, Bright JJ
  J Immunol. 2008
  PubMed ID: 18832727
   
  
• STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease.
  O'Malley JT, Eri RD, Stritesky GL, Mathur AN, Chang HC, Hogenesch H, Srinivasan M, Kaplan MH
  J Immunol. 2008
  PubMed ID: 18802110
   
  
• Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
  Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
  Genome Res. 2008
  PubMed ID: 18799693
   
  
• Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region.
  Kawasaki A, Ito I, Hikami K, Ohashi J, Hayashi T, Goto D, Matsumoto I, Ito S, Tsutsumi A, Koga M, Arinami T, Graham RR, Hom G, Takasaki Y, Hashimoto H, Behrens TW, Sumida T, Tsuchiya N
  Arthritis Res Ther. 2008
  PubMed ID: 18803832
   
  
• Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1.
  Devoss JJ, Shum AK, Johannes KP, Lu W, Krawisz AK, Wang P, Yang T, Leclair NP, Austin C, Strauss EC, Anderson MS
  J Immunol. 2008
  PubMed ID: 18768863
   
  
• Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
  Graham RR, Cotsapas C, Davies L, Hackett R, Lessard CJ, Leon JM, Burtt NP, Guiducci C, Parkin M, Gates C, Plenge RM, Behrens TW, Wither JE, Rioux JD, Fortin PR, Graham DC, Wong AK, Vyse TJ, Daly MJ, Altshuler D, Moser KL, Gaffney PM
  Nat Genet. 2008
  PubMed ID: 19165918
   
  
• Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity.
  Martin SF, Dudda JC, Bachtanian E, Lembo A, Liller S, Dürr C, Heimesaat MM, Bereswill S, Fejer G, Vassileva R, Jakob T, Freudenberg N, Termeer CC, Johner C, Galanos C, Freudenberg MA
  J Exp Med. 2008
  PubMed ID: 18725520
   
  
• Transcription factor-dependent chromatin remodeling of Il18r1 during Th1 and Th2 differentiation.
  Yu Q, Chang HC, Ahyi AN, Kaplan MH
  J Immunol. 2008
  PubMed ID: 18714006
   
  
• Autoregulation of Th1-mediated inflammation by twist1.
  Niesner U, Albrecht I, Janke M, Doebis C, Loddenkemper C, Lexberg MH, Eulenburg K, Kreher S, Koeck J, Baumgrass R, Bonhagen K, Kamradt T, Enghard P, Humrich JY, Rutz S, Schulze-Topphoff U, Aktas O, Bartfeld S, Radbruch H, Hegazy AN, Löhning M, Baumgart DC, Duchmann R, Rudwaleit M, Häupl T, Gitelman I, Krenn V, Gruen J, Sieper J, Zeitz M, Wiedenmann B, Zipp F, Hamann A, Janitz M, Scheffold A, Burmester GR, Chang HD, Radbruch A
  J Exp Med. 2008
  PubMed ID: 18663125
   
  
• Stat4 suppresses the proliferation of connective tissue-type mast cells.
  Kataoka TR, Nishizawa Y
  Lab Invest. 2008
  PubMed ID: 18521064
   
  
• Interleukin-12 (IL-12) and IL-23 induction of substance p synthesis in murine T cells and macrophages is subject to IL-10 and transforming growth factor beta regulation.
  Blum A, Setiawan T, Hang L, Stoyanoff K, Weinstock JV
  Infect Immun. 2008
  PubMed ID: 18505813
   
  
• Association of a TRAF1 and a STAT4 gene polymorphism with increased risk for rheumatoid arthritis in a genetically homogeneous population.
  Zervou MI, Sidiropoulos P, Petraki E, Vazgiourakis V, Krasoudaki E, Raptopoulou A, Kritikos H, Choustoulaki E, Boumpas DT, Goulielmos GN
  Hum Immunol. 2008
  PubMed ID: 18625278
   
  
• Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages.
  Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, Wang YH, Watowich SS, Jetten AM, Tian Q, Dong C
  Immunity. 2008
  PubMed ID: 18599325
   
  
• Association of STAT4 with rheumatoid arthritis: a replication study in three European populations.
  Orozco G, Alizadeh BZ, Delgado-Vega AM, González-Gay MA, Balsa A, Pascual-Salcedo D, Fernández-Gutierrez B, González-Escribano MF, Petersson IF, van Riel PL, Barrera P, Coenen MJ, Radstake TR, van Leeuwen MA, Wijmenga C, Koeleman BP, Alarcón-Riquelme M, Martín J
  Arthritis Rheum. 2008
  PubMed ID: 18576336
   
  
• Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population.
  Kobayashi S, Ikari K, Kaneko H, Kochi Y, Yamamoto K, Shimane K, Nakamura Y, Toyama Y, Mochizuki T, Tsukahara S, Kawaguchi Y, Terai C, Hara M, Tomatsu T, Yamanaka H, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Okamoto H, Kamatani N, Momohara S
  Arthritis Rheum. 2008
  PubMed ID: 18576330
   
  
• A common STAT4 risk haplotype for Systemic Lupus Erythematosus is over-expressed, correlates with anti-dsDNA production and shows additive effects with two IRF5 risk alleles.
  Sigurdsson S, Nordmark G, Garnier S, Grundberg E, Kwan T, Nilsson O, Eloranta ML, Gunnarsson I, Svenungsson E, Sturfelt G, Bengtsson AA, Jönsen A, Truedsson L, Rantapää-Dahlqvist S, Eriksson C, Alm G, Göring HH, Pastinen T, Syvänen AC, Rönnblom L
  Hum Mol Genet. 2008
  PubMed ID: 18579578
   
  
• STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians.
  Palomino-Morales RJ, Rojas-Villarraga A, González CI, Ramírez G, Anaya JM, Martín J
  Genes Immun. 2008
  PubMed ID: 18432273
   
  
• IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD.
  Villarino AV, Artis D, Bezbradica JS, Miller O, Saris CJ, Joyce S, Hunter CA
  Int Immunol. 2008
  PubMed ID: 18375937
   
  
• Overlapping and distinct roles of STAT4 and T-bet in the regulation of T cell differentiation and allergic airway inflammation.
  Furuta S, Kagami S, Tamachi T, Ikeda K, Fujiwara M, Suto A, Hirose K, Watanabe N, Saito Y, Iwamoto I, Nakajima H
  J Immunol. 2008
  PubMed ID: 18453585
   
  
• IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection.
  Wilson DC, Matthews S, Yap GS
  J Immunol. 2008
  PubMed ID: 18424713
   
  
• Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.
  Barton A, Thomson W, Ke X, Eyre S, Hinks A, Bowes J, Gibbons L, Plant D, Wellcome Trust Case Control Consortium, Wilson AG, Marinou I, Morgan A, Emery P, YEAR consortium, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Worthington J
  Hum Mol Genet. 2008
  PubMed ID: 18434327
   
  
• GUDMAP: the genitourinary developmental molecular anatomy project.
  McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
  J Am Soc Nephrol. 2008
  PubMed ID: 18287559
   
  
• Variant form of STAT4 is associated with primary Sjögren's syndrome.
  Korman BD, Alba MI, Le JM, Alevizos I, Smith JA, Nikolov NP, Kastner DL, Remmers EF, Illei GG
  Genes Immun. 2008
  PubMed ID: 18273036
   
  
• Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival.
  Peck-Palmer OM, Unsinger J, Chang KC, Davis CG, McDunn JE, Hotchkiss RS
  J Leukoc Biol. 2008
  PubMed ID: 18211965
   
  
• BART is essential for nuclear retention of STAT3.
  Muromoto R, Sekine Y, Imoto S, Ikeda O, Okayama T, Sato N, Matsuda T
  Int Immunol. 2008
  PubMed ID: 18234692
   
  
• Toward a confocal subcellular atlas of the human proteome.
  Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
  Mol Cell Proteomics. 2008
  PubMed ID: 18029348
   
  
• Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
  Hom G, Graham RR, Modrek B, Taylor KE, Ortmann W, Garnier S, Lee AT, Chung SA, Ferreira RC, Pant PV, Ballinger DG, Kosoy R, Demirci FY, Kamboh MI, Kao AH, Tian C, Gunnarsson I, Bengtsson AA, Rantapää-Dahlqvist S, Petri M, Manzi S, Seldin MF, Rönnblom L, Syvänen AC, Criswell LA, Gregersen PK, Behrens TW
  N Engl J Med. 2008
  PubMed ID: 18204098
   
  
• IL-12 is required for anti-OX40-mediated CD4 T cell survival.
  Ruby CE, Montler R, Zheng R, Shu S, Weinberg AD
  J Immunol. 2008
  PubMed ID: 18250420
   
  
• Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
  International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), Harley JB, Alarcón-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL, Tsao BP, Vyse TJ, Langefeld CD, Nath SK, Guthridge JM, Cobb BL, Mirel DB, Marion MC, Williams AH, Divers J, Wang W, Frank SG, Namjou B, Gabriel SB, Lee AT, Gregersen PK, Behrens TW, Taylor KE, Fernando M, Zidovetzki R, Gaffney PM, Edberg JC, Rioux JD, Ojwang JO, James JA, Merrill JT, Gilkeson GS, Seldin MF, Yin H, Baechler EC, Li QZ, Wakeland EK, Bruner GR, Kaufman KM, Kelly JA
  Nat Genet. 2008
  PubMed ID: 18204446
   
  
• The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.
  Ueno T, Habicht A, Clarkson MR, Albin MJ, Yamaura K, Boenisch O, Popoola J, Wang Y, Yagita H, Akiba H, Ansari MJ, Yang J, Turka LA, Rothstein DM, Padera RF, Najafian N, Sayegh MH
  J Clin Invest. 2008
  PubMed ID: 18172549
   
  
• Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.
  Taylor KE, Remmers EF, Lee AT, Ortmann WA, Plenge RM, Tian C, Chung SA, Nititham J, Hom G, Kao AH, Demirci FY, Kamboh MI, Petri M, Manzi S, Kastner DL, Seldin MF, Gregersen PK, Behrens TW, Criswell LA
  PLoS Genet. 2008
  PubMed ID: 18516230
   
  
• Signal transducer and activator of transcription 4 (STAT4), but not IL-12 contributes to Pseudomonas aeruginosa-induced lung inflammation in mice.
  O'Sullivan R, Carrigan SO, Marshall JS, Lin TJ
  Immunobiology. 2008
  PubMed ID: 18514749
   
  
• Contribution of IL-12R mediated feedback loop to Th1 cell differentiation.
  Becskei A, Grusby MJ
  FEBS Lett. 2007
  PubMed ID: 17950290
   
  
• High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells.
  Miyagi T, Gil MP, Wang X, Louten J, Chu WM, Biron CA
  J Exp Med. 2007
  PubMed ID: 17846149
   
  
• Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Stat1 signals.
  Yang Y, Ochando JC, Bromberg JS, Ding Y
  Blood. 2007
  PubMed ID: 17575072
   
  
• Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
  Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B
  J Infect Dis. 2007
  PubMed ID: 17703412
   
  
• STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.
  Remmers EF, Plenge RM, Lee AT, Graham RR, Hom G, Behrens TW, de Bakker PI, Le JM, Lee HS, Batliwalla F, Li W, Masters SL, Booty MG, Carulli JP, Padyukov L, Alfredsson L, Klareskog L, Chen WV, Amos CI, Criswell LA, Seldin MF, Kastner DL, Gregersen PK
  N Engl J Med. 2007
  PubMed ID: 17804842
   
  
• Association of STAT4 with rheumatoid arthritis in the Korean population.
  Lee HS, Remmers EF, Le JM, Kastner DL, Bae SC, Gregersen PK
  Mol Med. 2007
  PubMed ID: 17932559
   
  
• Polymorphisms of STAT-6, STAT-4 and IFN-gamma genes and the risk of asthma in Chinese population.
  Li Y, Wu B, Xiong H, Zhu C, Zhang L
  Respir Med. 2007
  PubMed ID: 17532201
   
  
• Cytokines, signaling pathways, and effector molecules required for the control of Leishmania (Viannia) braziliensis in mice.
  Rocha FJ, Schleicher U, Mattner J, Alber G, Bogdan C
  Infect Immun. 2007
  PubMed ID: 17517868
   
  
• Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation.
  Tokumasa N, Suto A, Kagami S, Furuta S, Hirose K, Watanabe N, Saito Y, Shimoda K, Iwamoto I, Nakajima H
  Blood. 2007
  PubMed ID: 17395783
   
  
• IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype.
  Casey KA, Mescher MF
  J Immunol. 2007
  PubMed ID: 17548600
   
  
• Agonist-driven development of CD4+CD25+Foxp3+ regulatory T cells requires a second signal mediated by Stat6.
  Sanchez-Guajardo V, Tanchot C, O'Malley JT, Kaplan MH, Garcia S, Freitas AA
  J Immunol. 2007
  PubMed ID: 17548589
   
  
• Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation.
  Yu Q, Thieu VT, Kaplan MH
  EMBO J. 2007
  PubMed ID: 17380127
   
  
• Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma.
  Kim YK, Oh SY, Jeon SG, Park HW, Lee SY, Chun EY, Bang B, Lee HS, Oh MH, Kim YS, Kim JH, Gho YS, Cho SH, Min KU, Kim YY, Zhu Z
  J Immunol. 2007
  PubMed ID: 17404323
   
  
• Stat3 and Stat4 direct development of IL-17-secreting Th cells.
  Mathur AN, Chang HC, Zisoulis DG, Stritesky GL, Yu Q, O'Malley JT, Kapur R, Levy DE, Kansas GS, Kaplan MH
  J Immunol. 2007
  PubMed ID: 17404271
   
  
• Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis.
  Hildner KM, Schirmacher P, Atreya I, Dittmayer M, Bartsch B, Galle PR, Wirtz S, Neurath MF
  J Immunol. 2007
  PubMed ID: 17339437
   
  
• Pre-assembly of STAT4 with the human IFN-alpha/beta receptor-2 subunit is mediated by the STAT4 N-domain.
  Tyler DR, Persky ME, Matthews LA, Chan S, Farrar JD
  Mol Immunol. 2007
  PubMed ID: 17095088
   
  
• IL-2 and IL-18 attenuation of airway hyperresponsiveness requires STAT4, IFN-gamma, and natural killer cells.
  Matsubara S, Takeda K, Kodama T, Joetham A, Miyahara N, Koya T, Swasey CH, Okamoto M, Dakhama A, Gelfand EW
  Am J Respir Cell Mol Biol. 2007
  PubMed ID: 17038663
   
  
• Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation.
  Longman RS, Braun D, Pellegrini S, Rice CM, Darnell RB, Albert ML
  Blood. 2007
  PubMed ID: 17018853
   
  
• Recovery from spinal cord injury in tumor necrosis factor-alpha, signal transducers and activators of transcription 4 and signal transducers and activators of transcription 6 null mice.
  Fraidakis MJ, Kiyotani T, Pernold K, Bergström J, Olson L
  Neuroreport. 2007
  PubMed ID: 17301687
   
  
• Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.
  Villarino AV, Tato CM, Stumhofer JS, Yao Z, Cui YK, Hennighausen L, O'Shea JJ, Hunter CA
  J Exp Med. 2007
  PubMed ID: 17227909
   
  
• Adjuvant effect of anti-4-1BB mAb administration in adoptive T cell therapy of cancer.
  Li Q, Iuchi T, Jure-Kunkel MN, Chang AE
  Int J Biol Sci. 2007
  PubMed ID: 18071585
   
  
• Role of Stat4-mediated signal transduction events in the generation of aggressor CD4+ T cells in herpetic stromal keratitis pathogenesis.
  Banerjee K, Biswas PS, Rouse BT
  J Interferon Cytokine Res. 2007
  PubMed ID: 17266445
   
  
• The STAT4 and STAT6 pathways in pancreatitis-associated lung injury.
  Simovic MO, Ballard BR, Gray KD, Stain SC
  J Surg Res. 2007
  PubMed ID: 17109890
   
  
• NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation.
  Remoli ME, Ragimbeau J, Giacomini E, Gafa V, Severa M, Lande R, Pellegrini S, Coccia EM
  J Leukoc Biol. 2007
  PubMed ID: 17046972
   
  
• Microenvironment-dependent requirement of STAT4 for the induction of P-selectin ligands and effector cytokines on CD4+ T cells in healthy and parasite-infected mice.
  Syrbe U, Hoffmann U, Schlawe K, Liesenfeld O, Erb K, Hamann A
  J Immunol. 2006
  PubMed ID: 17114437
   
  
• Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-alpha.
  Berenson LS, Gavrieli M, Farrar JD, Murphy TL, Murphy KM
  J Immunol. 2006
  PubMed ID: 17015705
   
  
• The consensus coding sequences of human breast and colorectal cancers.
  Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
  Science. 2006
  PubMed ID: 16959974
   
  
• STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus.
  Xu Z, Duan B, Croker BP, Morel L
  Clin Immunol. 2006
  PubMed ID: 16713741
   
  
• Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation.
  Shaw MH, Freeman GJ, Scott MF, Fox BA, Bzik DJ, Belkaid Y, Yap GS
  J Immunol. 2006
  PubMed ID: 16751369
   
  
• T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent.
  Zhang F, Boothby M
  J Exp Med. 2006
  PubMed ID: 16717115
   
  
• Arthritis induced with cartilage-specific antibodiesis IL-4-dependent.
  Nandakumar KS, Holmdahl R
  Eur J Immunol. 2006
  PubMed ID: 16688680
   
  
• Peptide YY attenuates STAT1 and STAT3 activation induced by TNF-alpha in acinar cell line AR42J.
  Robinson K, Vona-Davis L, Riggs D, Jackson B, McFadden D
  J Am Coll Surg. 2006
  PubMed ID: 16648019
   
  
• IL-4 induces in vivo production of IFN-gamma by NK and NKT cells.
  Morris SC, Orekhova T, Meadows MJ, Heidorn SM, Yang J, Finkelman FD
  J Immunol. 2006
  PubMed ID: 16621996
   
  
• BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
  Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
  PLoS Biol. 2006
  PubMed ID: 16602821
   
  
• IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3.
  Owaki T, Asakawa M, Kamiya S, Takeda K, Fukai F, Mizuguchi J, Yoshimoto T
  J Immunol. 2006
  PubMed ID: 16493033
   
  
• Impairment of axotomy-induced pituitary adenylyl cyclase-activating peptide gene expression in T helper 2 lymphocyte-deficient mice.
  Armstrong BD, Abad C, Chhith S, Cheung-Lau G, Hajji OE, Coute AC, Ngo DH, Waschek JA
  Neuroreport. 2006
  PubMed ID: 16462603
   
  
• Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway.
  Palmqvist P, Lundberg P, Persson E, Johansson A, Lundgren I, Lie A, Conaway HH, Lerner UH
  J Biol Chem. 2006
  PubMed ID: 16251181
   
  
• STAT4/6-dependent differential regulation of chemokine receptors.
  Kim SH, Gunst KV, Sarvetnick N
  Clin Immunol. 2006
  PubMed ID: 16413227
   
  
• STAT4- and STAT6-signaling molecules in a murine model of multiple sclerosis.
  Rodriguez M, Zoecklein L, Gamez JD, Pavelko KD, Papke LM, Nakane S, Howe C, Radhakrishnan S, Hansen MJ, David CS, Warrington AE, Pease LR
  FASEB J. 2006
  PubMed ID: 16352646
   
  
• Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains.
  Farber CR, Corva PM, Medrano JF
  BMC Genomics. 2006
  PubMed ID: 16670015
   
  
• IL-27 limits IL-2 production during Th1 differentiation.
  Villarino AV, Stumhofer JS, Saris CJ, Kastelein RA, de Sauvage FJ, Hunter CA
  J Immunol. 2006
  PubMed ID: 16365415
   
  
• Allograft rejection requires STAT5a/b-regulated antiapoptotic activity in T cells but not B cells.
  Zhang Y, Kirken RA, Furian L, Janczewska S, Qu X, Hancock WW, Wang M, Tejpal N, Kerman R, Kahan BD, Stepkowski SM
  J Immunol. 2006
  PubMed ID: 16365403
   
  
• Differential requirement of signal transducer and activator of transcription-4 (Stat4) and Stat6 in a thyrotropin receptor-289-adenovirus-induced model of Graves' hyperthyroidism.
  Land KJ, Gudapati P, Kaplan MH, Seetharamaiah GS
  Endocrinology. 2006
  PubMed ID: 16195404
   
  
• STAT4 expression in human T cells is regulated by DNA methylation but not by promoter polymorphism.
  Shin HJ, Park HY, Jeong SJ, Park HW, Kim YK, Cho SH, Kim YY, Cho ML, Kim HY, Min KU, Lee CW
  J Immunol. 2005
  PubMed ID: 16301617
   
  
• A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells.
  Underhill GH, Zisoulis DG, Kolli KP, Ellies LG, Marth JD, Kansas GS
  Blood. 2005
  PubMed ID: 16099875
   
  
• Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.
  Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT
  Nat Immunol. 2005
  PubMed ID: 16200070
   
  
• A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.
  Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C
  Nat Immunol. 2005
  PubMed ID: 16200068
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• A role for IL-27 in early regulation of Th1 differentiation.
  Owaki T, Asakawa M, Morishima N, Hata K, Fukai F, Matsui M, Mizuguchi J, Yoshimoto T
  J Immunol. 2005
  PubMed ID: 16081786
   
  
• STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells.
  Yap WH, Yeoh E, Tay A, Brenner S, Venkatesh B
  FEBS Lett. 2005
  PubMed ID: 16081070
   
  
• Mycobacterial trehalose 6,6'-dimycolate preferentially induces type 1 helper T cell responses through signal transducer and activator of transcription 4 protein.
  Oiso R, Fujiwara N, Yamagami H, Maeda S, Matsumoto S, Nakamura S, Oshitani N, Matsumoto T, Arakawa T, Kobayashi K
  Microb Pathog. 2005
  PubMed ID: 15967629
   
  
• SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling.
  Tanaka T, Soriano MA, Grusby MJ
  Immunity. 2005
  PubMed ID: 15963787
   
  
• Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor.
  Harris DP, Goodrich S, Gerth AJ, Peng SL, Lund FE
  J Immunol. 2005
  PubMed ID: 15905519
   
  
• Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation.
  Curtsinger JM, Valenzuela JO, Agarwal P, Lins D, Mescher MF
  J Immunol. 2005
  PubMed ID: 15814665
   
  
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
  Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
  Nature. 2005
  PubMed ID: 15815621
   
  
• Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation.
  Smeltz RB, Chen J, Shevach EM
  Immunology. 2005
  PubMed ID: 15804285
   
  
• Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression.
  Rodriguez-Galán MC, Bream JH, Farr A, Young HA
  J Immunol. 2005
  PubMed ID: 15728489
   
  
• Different competitive capacities of Stat4- and Stat6-deficient CD4+ T cells during lymphophenia-driven proliferation.
  Sanchez-Guajardo V, Borghans JA, Marquez ME, Garcia S, Freitas AA
  J Immunol. 2005
  PubMed ID: 15661871
   
  
• Involvement of connective tissue-type mast cells in Th1 immune responses via Stat4 expression.
  Kataoka TR, Komazawa N, Morii E, Oboki K, Nakano T
  Blood. 2005
  PubMed ID: 15459017
   
  
• Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR).
  Kusaba H, Ghosh P, Derin R, Buchholz M, Sasaki C, Madara K, Longo DL
  J Biol Chem. 2005
  PubMed ID: 15522880
   
  
• Association analysis of signal transducer and activator of transcription 4 (STAT4) polymorphisms with asthma.
  Park BL, Cheong HS, Kim LH, Choi YH, Namgoong S, Park HS, Hong SJ, Choi BW, Lee JH, Park CS, Shin HD
  J Hum Genet. 2005
  PubMed ID: 15744455
   
  
• Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes.
  Pykäläinen M, Kinos R, Valkonen S, Rydman P, Kilpeläinen M, Laitinen LA, Karjalainen J, Nieminen M, Hurme M, Kere J, Laitinen T, Lahesmaa R
  J Allergy Clin Immunol. 2005
  PubMed ID: 15637551
   
  
• IL-12 protects against coxsackievirus B3-induced myocarditis by increasing IFN-gamma and macrophage and neutrophil populations in the heart.
  Fairweather D, Frisancho-Kiss S, Yusung SA, Barrett MA, Davis SE, Steele RA, Gatewood SJ, Rose NR
  J Immunol. 2005
  PubMed ID: 15611248
   
  
• Mouse brain organization revealed through direct genome-scale TF expression analysis.
  Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
  Science. 2004
  PubMed ID: 15618518
   
  
• Toll-dependent control mechanisms of CD4 T cell activation.
  Pasare C, Medzhitov R
  Immunity. 2004
  PubMed ID: 15539158
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• Stat 4 but not Stat 6 mediated immune mechanisms are essential in protection against plague.
  Elvin SJ, Williamson ED
  Microb Pathog. 2004
  PubMed ID: 15458778
   
  
• STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection.
  Deng JC, Zeng X, Newstead M, Moore TA, Tsai WC, Thannickal VJ, Standiford TJ
  J Immunol. 2004
  PubMed ID: 15356157
   
  
• Frontline: absence of functional STAT4 activation despite detectable tyrosine phosphorylation induced by murine IFN-alpha.
  Berenson LS, Farrar JD, Murphy TL, Murphy KM
  Eur J Immunol. 2004
  PubMed ID: 15307169
   
  
• A STAT4-dependent Th1 response is required for resistance to the helminth parasite Taenia crassiceps.
  Rodríguez-Sosa M, Saavedra R, Tenorio EP, Rosas LE, Satoskar AR, Terrazas LI
  Infect Immun. 2004
  PubMed ID: 15271915
   
  
• The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals.
  Kamezaki K, Shimoda K, Numata A, Matsuda T, Nakayama K, Harada M
  Int Immunol. 2004
  PubMed ID: 15226272
   
  
• Interferon alpha but not interleukin 12 activates STAT4 signaling in human vascular endothelial cells.
  Torpey N, Maher SE, Bothwell AL, Pober JS
  J Biol Chem. 2004
  PubMed ID: 15087447
   
  
• Early target genes of IL-12 and STAT4 signaling in th cells.
  Lund RJ, Chen Z, Scheinin J, Lahesmaa R
  J Immunol. 2004
  PubMed ID: 15153495
   
  
• GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells.
  Chi H, Lu B, Takekawa M, Davis RJ, Flavell RA
  EMBO J. 2004
  PubMed ID: 15044949
   
  
• Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
  Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
  Nature. 2004
  PubMed ID: 15057822
   
  
• Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivo.
  Chitnis T, Salama AD, Grusby MJ, Sayegh MH, Khoury SJ
  J Immunol. 2004
  PubMed ID: 15034039
   
  
• STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus.
  O'Sullivan A, Chang HC, Yu Q, Kaplan MH
  J Biol Chem. 2004
  PubMed ID: 14660657
   
  
• N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation.
  Ota N, Brett TJ, Murphy TL, Fremont DH, Murphy KM
  Nat Immunol. 2004
  PubMed ID: 14704793
   
  
• The susceptibility to experimental myasthenia gravis of STAT6-/- and STAT4-/- BALB/c mice suggests a pathogenic role of Th1 cells.
  Wang W, Ostlie NS, Conti-Fine BM, Milani M
  J Immunol. 2004
  PubMed ID: 14688314
   
  
• Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
  Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 14610273
   
  
• Regulatory functions of CD8+CD28- T cells in an autoimmune disease model.
  Najafian N, Chitnis T, Salama AD, Zhu B, Benou C, Yuan X, Clarkson MR, Sayegh MH, Khoury SJ
  J Clin Invest. 2003
  PubMed ID: 14523041
   
  
• Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity.
  Buxbaum LU, Denise H, Coombs GH, Alexander J, Mottram JC, Scott P
  J Immunol. 2003
  PubMed ID: 14500670
   
  
• STAT4 requires the N-terminal domain for efficient phosphorylation.
  Chang HC, Zhang S, Oldham I, Naeger L, Hoey T, Kaplan MH
  J Biol Chem. 2003
  PubMed ID: 12805384
   
  
• Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses.
  Hoey T, Zhang S, Schmidt N, Yu Q, Ramchandani S, Xu X, Naeger LK, Sun YL, Kaplan MH
  EMBO J. 2003
  PubMed ID: 12912921
   
  
• Distinct requirements for Stat4 and Stat6 in hematopoietic progenitor cell responses to growth factors and chemokines.
  Kaplan MH, Chang HC, Cooper S, Lee Y, Broxmeyer HE
  J Hematother Stem Cell Res. 2003
  PubMed ID: 12965077
   
  
• Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice.
  Jacob CO, Zang S, Li L, Ciobanu V, Quismorio F, Mizutani A, Satoh M, Koss M
  J Immunol. 2003
  PubMed ID: 12874250
   
  
• Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury.
  Yokota N, Burne-Taney M, Racusen L, Rabb H
  Am J Physiol Renal Physiol. 2003
  PubMed ID: 12709397
   
  
• PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4.
  Arora T, Liu B, He H, Kim J, Murphy TL, Murphy KM, Modlin RL, Shuai K
  J Biol Chem. 2003
  PubMed ID: 12716907
   
  
• Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease.
  Lovato P, Brender C, Agnholt J, Kelsen J, Kaltoft K, Svejgaard A, Eriksen KW, Woetmann A, Ødum N
  J Biol Chem. 2003
  PubMed ID: 12615922
   
  
• Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis.
  Singh RR, Saxena V, Zang S, Li L, Finkelman FD, Witte DP, Jacob CO
  J Immunol. 2003
  PubMed ID: 12707364
   
  
• STAT4 signal pathways regulate inflammation and airway physiology changes in allergic airway inflammation locally via alteration of chemokines.
  Raman K, Kaplan MH, Hogaboam CM, Berlin A, Lukacs NW
  J Immunol. 2003
  PubMed ID: 12646654
   
  
• Expression and activation of STAT proteins during mouse retina development.
  Zhang SS, Wei JY, Li C, Barnstable CJ, Fu XY
  Exp Eye Res. 2003
  PubMed ID: 12634107
   
  
• GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet.
  Usui T, Nishikomori R, Kitani A, Strober W
  Immunity. 2003
  PubMed ID: 12648458
   
  
• IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis.
  Grabie N, Delfs MW, Westrich JR, Love VA, Stavrakis G, Ahmad F, Seidman CE, Seidman JG, Lichtman AH
  J Clin Invest. 2003
  PubMed ID: 12618521
   
  
• CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism.
  Chung DR, Kasper DL, Panzo RJ, Chitnis T, Grusby MJ, Sayegh MH, Tzianabos AO, Chtinis T
  J Immunol. 2003
  PubMed ID: 12574364
   
  
• Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection.
  Shen XD, Ke B, Zhai Y, Gao F, Anselmo D, Lassman CR, Busuttil RW, Kupiec-Weglinski JW
  Hepatology. 2003
  PubMed ID: 12540779
   
  
• Activated STAT4 and a functional role for IL-12 in human Peyer's patches.
  Monteleone G, Holloway J, Salvati VM, Pender SL, Fairclough PD, Croft N, MacDonald TT
  J Immunol. 2003
  PubMed ID: 12496413
   
  
• Relative importance of STAT4 in murine tuberculosis.
  Sugawara I, Yamada H, Mizuno S
  J Med Microbiol. 2003
  PubMed ID: 12488562
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
  Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
  Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
  Nature. 2002
  PubMed ID: 12466851
   
  
• Initial sequencing and comparative analysis of the mouse genome.
  Mouse Genome Sequencing Consortium, Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough R, Alexandersson M, An P, Antonarakis SE, Attwood J, Baertsch R, Bailey J, Barlow K, Beck S, Berry E, Birren B, Bloom T, Bork P, Botcherby M, Bray N, Brent MR, Brown DG, Brown SD, Bult C, Burton J, Butler J, Campbell RD, Carninci P, Cawley S, Chiaromonte F, Chinwalla AT, Church DM, Clamp M, Clee C, Collins FS, Cook LL, Copley RR, Coulson A, Couronne O, Cuff J, Curwen V, Cutts T, Daly M, David R, Davies J, Delehaunty KD, Deri J, Dermitzakis ET, Dewey C, Dickens NJ, Diekhans M, Dodge S, Dubchak I, Dunn DM, Eddy SR, Elnitski L, Emes RD, Eswara P, Eyras E, Felsenfeld A, Fewell GA, Flicek P, Foley K, Frankel WN, Fulton LA, Fulton RS, Furey TS, Gage D, Gibbs RA, Glusman G, Gnerre S, Goldman N, Goodstadt L, Grafham D, Graves TA, Green ED, Gregory S, Guigó R, Guyer M, Hardison RC, Haussler D, Hayashizaki Y, Hillier LW, Hinrichs A, Hlavina W, Holzer T, Hsu F, Hua A, Hubbard T, Hunt A, Jackson I, Jaffe DB, Johnson LS, Jones M, Jones TA, Joy A, Kamal M, Karlsson EK, Karolchik D, Kasprzyk A, Kawai J, Keibler E, Kells C, Kent WJ, Kirby A, Kolbe DL, Korf I, Kucherlapati RS, Kulbokas EJ, Kulp D, Landers T, Leger JP, Leonard S, Letunic I, Levine R, Li J, Li M, Lloyd C, Lucas S, Ma B, Maglott DR, Mardis ER, Matthews L, Mauceli E, Mayer JH, McCarthy M, McCombie WR, McLaren S, McLay K, McPherson JD, Meldrim J, Meredith B, Mesirov JP, Miller W, Miner TL, Mongin E, Montgomery KT, Morgan M, Mott R, Mullikin JC, Muzny DM, Nash WE, Nelson JO, Nhan MN, Nicol R, Ning Z, Nusbaum C, O'Connor MJ, Okazaki Y, Oliver K, Overton-Larty E, Pachter L, Parra G, Pepin KH, Peterson J, Pevzner P, Plumb R, Pohl CS, Poliakov A, Ponce TC, Ponting CP, Potter S, Quail M, Reymond A, Roe BA, Roskin KM, Rubin EM, Rust AG, Santos R, Sapojnikov V, Schultz B, Schultz J, Schwartz MS, Schwartz S, Scott C, Seaman S, Searle S, Sharpe T, Sheridan A, Shownkeen R, Sims S, Singer JB, Slater G, Smit A, Smith DR, Spencer B, Stabenau A, Stange-Thomann N, Sugnet C, Suyama M, Tesler G, Thompson J, Torrents D, Trevaskis E, Tromp J, Ucla C, Ureta-Vidal A, Vinson JP, Von Niederhausern AC, Wade CM, Wall M, Weber RJ, Weiss RB, Wendl MC, West AP, Wetterstrand K, Wheeler R, Whelan S, Wierzbowski J, Willey D, Williams S, Wilson RK, Winter E, Worley KC, Wyman D, Yang S, Yang SP, Zdobnov EM, Zody MC, Lander ES
  Nature. 2002
  PubMed ID: 12466850
   
  
• A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3.
  Nakayama K, Kim KW, Miyajima A
  EMBO J. 2002
  PubMed ID: 12426389
   
  
• Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1.
  Eyles JL, Metcalf D, Grusby MJ, Hilton DJ, Starr R
  J Biol Chem. 2002
  PubMed ID: 12221108
   
  
• Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent.
  Buxbaum LU, Uzonna JE, Goldschmidt MH, Scott P
  Eur J Immunol. 2002
  PubMed ID: 12555666
   
  
• Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling.
  Nishikomori R, Usui T, Wu CY, Morinobu A, O'Shea JJ, Strober W
  J Immunol. 2002
  PubMed ID: 12370372
   
  
• Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection.
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• Neonatal tolerance in the absence of Stat4- and Stat6- dependent Th cell differentiation.
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• The human perforin gene is a direct target of STAT4 activated by IL-12 in NK cells.
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• IL-12, while beneficial, is not essential for the host response to VSV encephalitis.
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  J Neuroimmunol. 2002
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• Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size.
  Sho M, Yamada A, Najafian N, Salama AD, Harada H, Sandner SE, Sanchez-Fueyo A, Zheng XX, Strom TB, Sayegh MH
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• Adenovirus-mediated interferon gamma gene therapy for allergic asthma: involvement of interleukin 12 and STAT4 signaling.
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• Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection.
  Nguyen KB, Watford WT, Salomon R, Hofmann SR, Pien GC, Morinobu A, Gadina M, O'Shea JJ, Biron CA
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• STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation.
  Morinobu A, Gadina M, Strober W, Visconti R, Fornace A, Montagna C, Feldman GM, Nishikomori R, O'Shea JJ
  Proc Natl Acad Sci U S A. 2002
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• IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms.
  Finnegan A, Grusby MJ, Kaplan CD, O'Neill SK, Eibel H, Koreny T, Czipri M, Mikecz K, Zhang J
  J Immunol. 2002
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• Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling.
  Freudenberg MA, Merlin T, Kalis C, Chvatchko Y, Stübig H, Galanos C
  J Immunol. 2002
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• The homeostasis but not the differentiation of T cells is regulated by p27(Kip1).
  Shen R, Kaplan MH
  J Immunol. 2002
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• Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M.
  Broxmeyer HE, Bruns HA, Zhang S, Cooper S, Hangoc G, McKenzie AN, Dent AL, Schindler U, Naeger LK, Hoey T, Kaplan MH
  Immunity. 2002
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• T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells.
  Afkarian M, Sedy JR, Yang J, Jacobson NG, Cereb N, Yang SY, Murphy TL, Murphy KM
  Nat Immunol. 2002
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• A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
  Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD
  Science. 2002
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• Involvement of receptor-interacting protein 2 in innate and adaptive immune responses.
  Chin AI, Dempsey PW, Bruhn K, Miller JF, Xu Y, Cheng G
  Nature. 2002
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• Signaling through the JAK/STAT pathway, recent advances and future challenges.
  Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW
  Gene. 2002
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• Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.
  Nakahira M, Ahn HJ, Park WR, Gao P, Tomura M, Park CS, Hamaoka T, Ohta T, Kurimoto M, Fujiwara H
  J Immunol. 2002
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• A mandatory role for STAT4 in IL-12 induction of mouse T cell CCR5.
  Iwasaki M, Mukai T, Nakajima C, Yang YF, Gao P, Yamaguchi N, Tomura M, Fujiwara H, Hamaoka T
  J Immunol. 2001
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• STAT4 is required for antibacterial defense but enhances mortality during polymicrobial sepsis.
  Godshall CJ, Lentsch AB, Peyton JC, Scott MJ, Cheadle WG
  Clin Diagn Lab Immunol. 2001
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• Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.
  Chitnis T, Najafian N, Benou C, Salama AD, Grusby MJ, Sayegh MH, Khoury SJ
  J Clin Invest. 2001
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• A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice.
  Poltorak A, Merlin T, Nielsen PJ, Sandra O, Smirnova I, Schupp I, Boehm T, Galanos C, Freudenberg MA
  J Immunol. 2001
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• Susceptibility to Leishmania mexicana infection is due to the inability to produce IL-12 rather than lack of IL-12 responsiveness.
  Rodriguez-Sosa M, Monteforte GM, Satoskar AR
  Immunol Cell Biol. 2001
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• Role of interleukin-12 and stat-4 in the regulation of airway inflammation and hyperreactivity in respiratory syncytial virus infection.
  Tekkanat KK, Maassab H, Berlin AA, Lincoln PM, Evanoff HL, Kaplan MH, Lukacs NW
  Am J Pathol. 2001
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• An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex.
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  J Immunol. 2001
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• Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells.
  White SJ, Underhill GH, Kaplan MH, Kansas GS
  J Immunol. 2001
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• Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.
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• Dysfunction of Stat4 leads to accelerated incidence of chemical-induced thymic lymphomas in mice.
  Zhang SS, Welte T, Fu XY
  Exp Mol Pathol. 2001
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• T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia.
  Huber SA, Sakkinen P, David C, Newell MK, Tracy RP
  Circulation. 2001
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• A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatment.
  Yap GS, Ortmann R, Shevach E, Sher A
  J Immunol. 2001
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• Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis.
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  J Exp Med. 2001
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• Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.
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  Immunity. 2001
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• The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4.
  Schindler H, Lutz MB, Röllinghoff M, Bogdan C
  J Immunol. 2001
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• Functional annotation of a full-length mouse cDNA collection.
  Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
  Nature. 2001
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• Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma.
  Ostrand-Rosenberg S, Grusby MJ, Clements VK
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• Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.
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• RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
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• Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
  Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
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• Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.
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• Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii.
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• Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi.
  Tarleton RL, Grusby MJ, Zhang L
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• Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2.
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• The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo.
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• The biology of Stat4 and Stat6.
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• Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets.
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• Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation.
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• Association of STATs with relatives and friends.
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• The Jak-STAT pathway.
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• STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis.
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  Eur J Immunol. 1999
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• Direct interaction of STAT4 with the IL-12 receptor.
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• Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells.
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• Cytokines, Jaks, Stats, health and disease.
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• Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling.
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• Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.
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• High-efficiency full-length cDNA cloning.
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• A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells.
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• JAK/STAT signaling by cytokine receptors.
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  Curr Opin Immunol. 1998
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• Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA.
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• STATs as activators of apoptosis.
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• Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response.
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• Structure of the amino-terminal protein interaction domain of STAT-4.
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• Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy.
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• Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation.
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• The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs).
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• STATs and gene regulation.
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• cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3.
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