BRCA1

Summary Top Help

Gene Description:

breast cancer 1; breast cancer 1, early onset

Synonyms:

PSCP, RNF53, PPP1R53, BRCC1, PNCA4, BRCA1, BRCAI, Brca1, BROVCA1, IRIS

Orthologs:

Human BRCA1 (protein-coding), Mouse Brca1 (protein-coding), Rat Brca1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr17:41196312..41322420 (126.11 kb) View in Genome Browser

(Mouse) NCBIM37 - chr11:101350078..101413269 (63.19 kb) View in Genome Browser

(Rat) RGSC3.4 - chr10:90513630..90572676 (595 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for BRCA1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for BRCA1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 1

Biocarta: 5

Reactome: 8

NCI-Nature Pathway Interaction Database: 10

Gene Ontology: 82

Ubiquitin ligase complex	GO:0000151
Double-strand break repair via homologous recombination	GO:0000724
Condensed nuclear chromosome	GO:0000794
Ruffle	GO:0001726
DNA binding	GO:0003677
Damaged DNA binding	GO:0003684
Transcription coactivator activity	GO:0003713
RNA binding	GO:0003723
Ubiquitin-protein ligase activity	GO:0004842
Protein binding	GO:0005515
Intracellular	GO:0005622
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Cytoplasm	GO:0005737
Mitochondrial matrix	GO:0005759
Plasma membrane	GO:0005886
Focal adhesion	GO:0005925
DNA replication	GO:0006260
DNA repair	GO:0006281
Postreplication repair	GO:0006301
Double-strand break repair	GO:0006302
DNA recombination	GO:0006310
Regulation of gene expression by genetic imprinting	GO:0006349
Regulation of transcription from RNA polymerase II promoter	GO:0006357
Regulation of transcription from RNA polymerase III promoter	GO:0006359
Apoptotic process	GO:0006915
Response to DNA damage stimulus	GO:0006974
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978
Cell cycle	GO:0007049
Chromosome segregation	GO:0007059
Centrosome cycle	GO:0007098
Brain development	GO:0007420
Response to nutrient	GO:0007584
Zinc ion binding	GO:0008270
Gamma-tubulin ring complex	GO:0008274
DNA damage response, signal transduction resulting in induction of apoptosis	GO:0008630
Dosage compensation by inactivation of X chromosome	GO:0009048
Response to ionizing radiation	GO:0010212
Tubulin binding	GO:0015631
Protein ubiquitination	GO:0016567
Ligase activity	GO:0016874
Enzyme binding	GO:0019899
Androgen receptor signaling pathway	GO:0030521
Ribonucleoprotein complex	GO:0030529
Positive regulation of protein ubiquitination	GO:0031398
BRCA1-BARD1 complex	GO:0031436
G2/M transition DNA damage checkpoint	GO:0031572
Ubiquitin protein ligase binding	GO:0031625
Filamentous actin	GO:0031941
Response to estradiol stimulus	GO:0032355
Response to lipid	GO:0033993
Substrate adhesion-dependent cell spreading	GO:0034446
Positive regulation of histone acetylation	GO:0035066
Negative regulation of histone acetylation	GO:0035067
Regulation of cell proliferation	GO:0042127
Regulation of apoptotic process	GO:0042981
Chordate embryonic development	GO:0043009
Protein complex	GO:0043234
Response to estrogen stimulus	GO:0043627
Regulation of DNA methylation	GO:0044030
Transcription regulatory region DNA binding	GO:0044212
Negative regulation of fatty acid biosynthetic process	GO:0045717
Positive regulation of DNA repair	GO:0045739
Negative regulation of transcription, DNA-dependent	GO:0045892
Positive regulation of transcription, DNA-dependent	GO:0045893
Positive regulation of transcription from RNA polymerase II promoter	GO:0045944
Negative regulation of centriole replication	GO:0046600
Metal ion binding	GO:0046872
Androgen receptor binding	GO:0050681
Positive regulation of histone H3-K4 methylation	GO:0051571
Negative regulation of histone H3-K4 methylation	GO:0051572
Negative regulation of histone H3-K9 methylation	GO:0051573
Positive regulation of histone H3-K9 methylation	GO:0051574
Protein autoubiquitination	GO:0051865
Positive regulation of histone H4-K20 methylation	GO:0070512
BRCA1-A complex	GO:0070531
Positive regulation of cell cycle arrest	GO:0071158
Cellular response to indole-3-methanol	GO:0071681
Protein K6-linked ubiquitination	GO:0085020
Regulation of cell motility	GO:2000145
Positive regulation of histone H3-K9 acetylation	GO:2000617
Positive regulation of histone H4-K16 acetylation	GO:2000620

Publications from PubMed Top Help

Publications: 1866

Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer.
Bolton KL, Chenevix-Trench G, Goh C, Sadetzki S, Ramus SJ, Karlan BY, Lambrechts D, Despierre E, Barrowdale D, McGuffog L, Healey S, Easton DF, Sinilnikova O, Benítez J, García MJ, Neuhausen S, Gail MH, Hartge P, Peock S, Frost D, Evans DG, Eeles R, Godwin AK, Daly MB, Kwong A, Ma ES, Lázaro C, Blanco I, Montagna M, D'Andrea E, Nicoletto MO, Johnatty SE, Kjær SK, Jensen A, Høgdall E, Goode EL, Fridley BL, Loud JT, Greene MH, Mai PL, Chetrit A, Lubin F, Hirsh-Yechezkel G, Glendon G, Andrulis IL, Toland AE, Senter L, Gore ME, Gourley C, Michie CO, Song H, Tyrer J, Whittemore AS, McGuire V, Sieh W, Kristoffersson U, Olsson H, Borg Å, Levine DA, Steele L, Beattie MS, Chan S, Nussbaum RL, Moysich KB, Gross J, Cass I, Walsh C, Li AJ, Leuchter R, Gordon O, Garcia-Closas M, Gayther SA, Chanock SJ, Antoniou AC, Pharoah PD, EMBRACE, kConFab Investigators, Cancer Genome Atlas Research Network
JAMA. 2012
PubMed ID: 22274685
Yin Yang 1 positively regulates BRCA1 and inhibits mammary cancer formation.
Lee MH, Lahusen T, Wang RH, Xiao C, Xu X, Hwang YS, He WW, Shi Y, Deng CX
Oncogene. 2012
PubMed ID: 21666725
E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes.
David Y, Ternette N, Edelmann MJ, Ziv T, Gayer B, Sertchook R, Dadon Y, Kessler BM, Navon A
J Biol Chem. 2011
PubMed ID: 21965653
BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.
Drost R, Bouwman P, Rottenberg S, Boon U, Schut E, Klarenbeek S, Klijn C, van der Heijden I, van der Gulden H, Wientjens E, Pieterse M, Catteau A, Green P, Solomon E, Morris JR, Jonkers J
Cancer Cell. 2011
PubMed ID: 22172724
Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence.
Tu Z, Aird KM, Bitler BG, Nicodemus JP, Beeharry N, Xia B, Yen TJ, Zhang R
Dev Cell. 2011
PubMed ID: 22137763
A high response rate to liposomal doxorubicin is seen among women with BRCA mutations treated for recurrent epithelial ovarian cancer.
Adams SF, Marsh EB, Elmasri W, Halberstadt S, Vandecker S, Sammel MD, Bradbury AR, Daly M, Karlan B, Rubin SC
Gynecol Oncol. 2011
PubMed ID: 21945552
BRCA1 is both a prognostic and predictive biomarker of response to chemotherapy in sporadic epithelial ovarian cancer.
Carser JE, Quinn JE, Michie CO, O'Brien EJ, McCluggage WG, Maxwell P, Lamers E, Lioe TF, Williams AR, Kennedy RD, Gourley C, Harkin DP
Gynecol Oncol. 2011
PubMed ID: 21920589
Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers.
Cox DG, Simard J, Sinnett D, Hamdi Y, Soucy P, Ouimet M, Barjhoux L, Verny-Pierre C, McGuffog L, Healey S, Szabo C, Greene MH, Mai PL, Andrulis IL, Ontario Cancer Genetics Network, Thomassen M, Gerdes AM, Caligo MA, Friedman E, Laitman Y, Kaufman B, Paluch SS, Borg Å, Karlsson P, Askmalm MS, Bustinza GB, SWE-BRCA Collaborators, Nathanson KL, Domchek SM, Rebbeck TR, Benítez J, Hamann U, Rookus MA, van den Ouweland AM, Ausems MG, Aalfs CM, van Asperen CJ, Devilee P, Gille HJ, HEBON, EMBRACE, Peock S, Frost D, Evans DG, Eeles R, Izatt L, Adlard J, Paterson J, Eason J, Godwin AK, Remon MA, Moncoutier V, Gauthier-Villars M, Lasset C, Giraud S, Hardouin A, Berthet P, Sobol H, Eisinger F, Bressac de Paillerets B, Caron O, Delnatte C, GEMO Study Collaborators, Goldgar D, Miron A, Ozcelik H, Buys S, Southey MC, Terry MB, Breast Cancer Family Registry, Singer CF, Dressler AC, Tea MK, Hansen TV, Johannsson O, Piedmonte M, Rodriguez GC, Basil JB, Blank S, Toland AE, Montagna M, Isaacs C, Blanco I, Gayther SA, Moysich KB, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Ditsch N, Arnold N, Niederacher D, Sutter C, Gadzicki D, Fiebig B, Caldes T, Laframboise R, Nevanlinna H, Chen X, Beesley J, Spurdle AB, Neuhausen SL, Ding YC, Couch FJ, Wang X, Peterlongo P, Manoukian S, Bernard L, Radice P, Easton DF, Chenevix-Trench G, Antoniou AC, Stoppa-Lyonnet D, Mazoyer S, Sinilnikova OM, Consortium of Investigators of Modifiers of BRCA1/2
Hum Mol Genet. 2011
PubMed ID: 21890493
Genetic polymorphisms in AURKA and BRCA1 are associated with breast cancer susceptibility in a Chinese Han population.
Ruan Y, Song AP, Wang H, Xie YT, Han JY, Sajdik C, Tian XX, Fang WG
J Pathol. 2011
PubMed ID: 21598251
BRCA1 mutations do not increase prostate cancer risk: results from a meta-analysis including new data.
Fachal L, Gómez-Caamaño A, Celeiro-Muñoz C, Peleteiro P, Blanco A, Carballo A, Forteza J, Carracedo A, Vega A
Prostate. 2011
PubMed ID: 21520156
Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteins.
Qin Y, Xu J, Aysola K, Begum N, Reddy V, Chai Y, Grizzle WE, Partridge EE, Reddy ES, Rao VN
J Cell Physiol. 2011
PubMed ID: 21344391
Characteristics of triple-negative breast cancer in patients with a BRCA1 mutation: results from a population-based study of young women.
Lee E, McKean-Cowdin R, Ma H, Spicer DV, Van Den Berg D, Bernstein L, Ursin G
J Clin Oncol. 2011
PubMed ID: 22010008
Variation in the BRCA2 gene in a child with medulloblastoma and a family history of breast cancer.
Bayrakli F, Akgun B, Soylemez B, Kaplan M, Gurelik M
J Neurosurg Pediatr. 2011
PubMed ID: 22044372
Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers.
Im KM, Kirchhoff T, Wang X, Green T, Chow CY, Vijai J, Korn J, Gaudet MM, Fredericksen Z, Shane Pankratz V, Guiducci C, Crenshaw A, McGuffog L, Kartsonaki C, Morrison J, Healey S, Sinilnikova OM, Mai PL, Greene MH, Piedmonte M, Rubinstein WS, HEBON, Hogervorst FB, Rookus MA, Collée JM, Hoogerbrugge N, van Asperen CJ, Meijers-Heijboer HE, Van Roozendaal CE, Caldes T, Perez-Segura P, Jakubowska A, Lubinski J, Huzarski T, Blecharz P, Nevanlinna H, Aittomäki K, Lazaro C, Blanco I, Barkardottir RB, Montagna M, D'Andrea E, kConFab, Devilee P, Olopade OI, Neuhausen SL, Peissel B, Bonanni B, Peterlongo P, Singer CF, Rennert G, Lejbkowicz F, Andrulis IL, Glendon G, Ozcelik H, Ontario Cancer Genetics Network, Toland AE, Caligo MA, SWE-BRCA, Beattie MS, Chan S, UKFOCR, Domchek SM, Nathanson KL, Rebbeck TR, Phelan C, Narod S, John EM, Hopper JL, Buys SS, Daly MB, Southey MC, Terry MB, Tung N, Hansen TV, Osorio A, Benitez J, Durán M, Weitzel JN, Garber J, Hamann U, EMBRACE, Peock S, Cook M, Oliver CT, Frost D, Platte R, Evans DG, Eeles R, Izatt L, Paterson J, Brewer C, Hodgson S, Morrison PJ, Porteous M, Walker L, Rogers MT, Side LE, Godwin AK, Schmutzler RK, Wappenschmidt B, Laitman Y, Meindl A, Deissler H, Varon-Mateeva R, Preisler-Adams S, Kast K, Venat-Bouvet L, Stoppa-Lyonnet D, Chenevix-Trench G, Easton DF, Klein RJ, Daly MJ, Friedman E, Dean M, Clark AG, Altshuler DM, Antoniou AC, Couch FJ, Offit K, Gold B
Hum Genet. 2011
PubMed ID: 21597964
Human epidermal growth factor receptor 2, Na+/H+ exchanger regulatory factor 1, and breast cancer susceptibility gene-1 as new biomarkers for familial breast cancers.
Mangia A, Malfettone A, Saponaro C, Tommasi S, Simone G, Paradiso A
Hum Pathol. 2011
PubMed ID: 21496870
Breast cancer 1 (BRCA1) protein expression as a prognostic marker in sporadic epithelial ovarian carcinoma: an NCIC CTG OV.16 correlative study.
Weberpals JI, Tu D, Squire JA, Amin MS, Islam S, Pelletier LB, O'Brien AM, Hoskins PJ, Eisenhauer EA
Ann Oncol. 2011
PubMed ID: 21368065
BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity.
Shakya R, Reid LJ, Reczek CR, Cole F, Egli D, Lin CS, deRooij DG, Hirsch S, Ravi K, Hicks JB, Szabolcs M, Jasin M, Baer R, Ludwig T
Science. 2011
PubMed ID: 22034435
Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells.
Konishi H, Mohseni M, Tamaki A, Garay JP, Croessmann S, Karnan S, Ota A, Wong HY, Konishi Y, Karakas B, Tahir K, Abukhdeir AM, Gustin JP, Cidado J, Wang GM, Cosgrove D, Cochran R, Jelovac D, Higgins MJ, Arena S, Hawkins L, Lauring J, Gross AL, Heaphy CM, Hosokawa Y, Gabrielson E, Meeker AK, Visvanathan K, Argani P, Bachman KE, Park BH
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21987798
BRCA1 is required for postreplication repair after UV-induced DNA damage.
Pathania S, Nguyen J, Hill SJ, Scully R, Adelmant GO, Marto JA, Feunteun J, Livingston DM
Mol Cell. 2011
PubMed ID: 21963239
Cdk1 and BRCA1 target γ-tubulin to microtubule domains.
Hubert T, Vandekerckhove J, Gettemans J
Biochem Biophys Res Commun. 2011
PubMed ID: 21951856
Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer.
Yang D, Khan S, Sun Y, Hess K, Shmulevich I, Sood AK, Zhang W
JAMA. 2011
PubMed ID: 21990299
Prophylactic and therapeutic mastectomy in BRCA mutation carriers: can the nipple be preserved?
Reynolds C, Davidson JA, Lindor NM, Glazebrook KN, Jakub JW, Degnim AC, Sandhu NP, Walsh MF, Hartmann LC, Boughey JC
Ann Surg Oncol. 2011
PubMed ID: 21947588
Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155.
Chang S, Wang RH, Akagi K, Kim KA, Martin BK, Cavallone L, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Haines DC, Basik M, Mai P, Poggi E, Isaacs C, Looi LM, Mun KS, Greene MH, Byers SW, Teo SH, Deng CX, Sharan SK
Nat Med. 2011
PubMed ID: 21946536
BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein.
Wei L, Lan L, Yasui A, Tanaka K, Saijo M, Matsuzawa A, Kashiwagi R, Maseki E, Hu Y, Parvin JD, Ishioka C, Chiba N
Cancer Sci. 2011
PubMed ID: 21756275
The BRCA1 ubiquitin ligase and homologous recombination repair.
Ohta T, Sato K, Wu W
FEBS Lett. 2011
PubMed ID: 21570976
BRCA1 tumour suppression occurs via heterochromatin-mediated silencing.
Zhu Q, Pao GM, Huynh AM, Suh H, Tonnu N, Nederlof PM, Gage FH, Verma IM
Nature. 2011
PubMed ID: 21901007
Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1-Interacting Genes.
Rebbeck TR, Mitra N, Domchek SM, Wan F, Friebel TM, Tran TV, Singer CF, Tea MK, Blum JL, Tung N, Olopade OI, Weitzel JN, Lynch HT, Snyder CL, Garber JE, Antoniou AC, Peock S, Evans DG, Paterson J, Kennedy MJ, Donaldson A, Dorkins H, Easton DF, Epidemiological Study of BRCA1 and BRCA2 Mutation Carriers (EMBRACE), Rubinstein WS, Daly MB, Isaacs C, Nevanlinna H, Couch FJ, Andrulis IL, Freidman E, Laitman Y, Ganz PA, Tomlinson GE, Neuhausen SL, Narod SA, Phelan CM, Greenberg R, Nathanson KL
Cancer Res. 2011
PubMed ID: 21799032
A conditional mouse model for measuring the frequency of homologous recombination events in vivo in the absence of essential genes.
Brown AD, Claybon AB, Bishop AJ
Mol Cell Biol. 2011
PubMed ID: 21709021
Protective effects of prepubertal genistein exposure on mammary tumorigenesis are dependent on BRCA1 expression.
de Assis S, Warri A, Benitez C, Helferich W, Hilakivi-Clarke L
Cancer Prev Res (Phila). 2011
PubMed ID: 21680703
Factors associated with an individuals' decision to withdraw from genetic counseling for BRCA1 and BRCA2 genes mutations: are personality traits involved?
Caruso A, Vigna C, Bigazzi V, Leone C, Maggi G, Martayan A, Sega FM, Cognetti F, Savarese A
Fam Cancer. 2011
PubMed ID: 21604195
Cancer worry among Norwegian male BRCA1/2 mutation carriers.
Strømsvik N, Råheim M, Gjengedal E
Fam Cancer. 2011
PubMed ID: 21603983
Adequacy of risk-reducing gynaecologic surgery in BRCA1 or BRCA2 mutation carriers and other women at high risk of pelvic serous cancer.
Kiely BE, Friedlander ML, Milne RL, Stanhope L, Russell P, Jenkins MA, Weideman P, McLachlan SA, Grant P, kConFab Investigators, Hopper JL, Phillips KA
Fam Cancer. 2011
PubMed ID: 21424757
A 67-year-old woman with BRCA 1 mutation associated with pancreatic adenocarcinoma.
Lowery M, Shah MA, Smyth E, Epstein A, Segal A, Rosengarten O, Isacson R, Drukker L, Keinan A, Rachkiman M, Reissman P, Gabizon A, Kelsen D, O'Reilly EM
J Gastrointest Cancer. 2011
PubMed ID: 20711688
p53-dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage.
Jiang J, Yang ES, Jiang G, Nowsheen S, Wang H, Wang T, Wang Y, Billheimer D, Chakravarthy AB, Brown M, Haffty B, Xia F
Cancer Res. 2011
PubMed ID: 21742769
MDC1 is ubiquitylated on its tandem BRCT domain and directly binds RAP80 in a UBC13-dependent manner.
Strauss C, Halevy T, Macarov M, Argaman L, Goldberg M
DNA Repair (Amst). 2011
PubMed ID: 21622030
Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers.
Antoniou AC, Kartsonaki C, Sinilnikova OM, Soucy P, McGuffog L, Healey S, Lee A, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Cattaneo E, Barile M, Pensotti V, Pasini B, Dolcetti R, Giannini G, Putignano AL, Varesco L, Radice P, Mai PL, Greene MH, Andrulis IL, Glendon G, Ozcelik H, Thomassen M, Gerdes AM, Kruse TA, Birk Jensen U, Crüger DG, Caligo MA, Laitman Y, Milgrom R, Kaufman B, Paluch-Shimon S, Friedman E, Loman N, Harbst K, Lindblom A, Arver B, Ehrencrona H, Melin B, SWE-BRCA, Nathanson KL, Domchek SM, Rebbeck T, Jakubowska A, Lubinski J, Gronwald J, Huzarski T, Byrski T, Cybulski C, Gorski B, Osorio A, Ramón y Cajal T, Fostira F, Andrés R, Benitez J, Hamann U, Hogervorst FB, Rookus MA, Hooning MJ, Nelen MR, van der Luijt RB, van Os TA, van Asperen CJ, Devilee P, Meijers-Heijboer HE, Gómez Garcia EB, HEBON, Peock S, Cook M, Frost D, Platte R, Leyland J, Evans DG, Lalloo F, Eeles R, Izatt L, Adlard J, Davidson R, Eccles D, Ong KR, Cook J, Douglas F, Paterson J, Kennedy MJ, Miedzybrodzka Z, EMBRACE, Godwin A, Stoppa-Lyonnet D, Buecher B, Belotti M, Tirapo C, Mazoyer S, Barjhoux L, Lasset C, Leroux D, Faivre L, Bronner M, Prieur F, Nogues C, Rouleau E, Pujol P, Coupier I, Frénay M, CEMO Study Collaborators, Hopper JL, Daly MB, Terry MB, John EM, Buys SS, Yassin Y, Miron A, Goldgar D, Breast Cancer Family Registry, Singer CF, Tea MK, Pfeiler G, Dressler AC, Hansen TO, Jønson L, Ejlertsen B, Barkardottir RB, Kirchhoff T, Offit K, Piedmonte M, Rodriguez G, Small L, Boggess J, Blank S, Basil J, Azodi M, Toland AE, Montagna M, Tognazzo S, Agata S, Imyanitov E, Janavicius R, Lazaro C, Blanco I, Pharoah PD, Sucheston L, Karlan BY, Walsh CS, Olah E, Bozsik A, Teo SH, Seldon JL, Beattie MS, van Rensburg EJ, Sluiter MD, Diez O, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Ruehl I, Varon-Mateeva R, Kast K, Deissler H, Niederacher D, Arnold N, Gadzicki D, Schönbuchner I, Caldes T, de la Hoya M, Nevanlinna H, Aittomäki K, Dumont M, Chiquette J, Tischkowitz M, Chen X, Beesley J, Spurdle AB, kConFab investigators, Neuhausen SL, Chun Ding Y, Fredericksen Z, Wang X, Pankratz VS, Couch F, Simard J, Easton DF, Chenevix-Trench G, CIMBA
Hum Mol Genet. 2011
PubMed ID: 21593217
Identification of novel intronic BRCA1 variants of uncertain significance in a Thai hereditary breast cancer family.
Ratanaphan A, Panomwan P, Canyuk B, Maipang T
J Genet. 2011
PubMed ID: 21869484
VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling.
Passemard S, El Ghouzzi V, Nasser H, Verney C, Vodjdani G, Lacaud A, Lebon S, Laburthe M, Robberecht P, Nardelli J, Mani S, Verloes A, Gressens P, Lelièvre V
J Clin Invest. 2011
PubMed ID: 21737879
Development of breast cancer in a 21-year-old childhood Wilms' tumor survivor with a BRCA1 2634delC mutation.
Dulude AM, D'Souza J, Harrison N, Ramanathan RK
Clin Breast Cancer. 2011
PubMed ID: 21729660
Genetic variation in IGF2 and HTRA1 and breast cancer risk among BRCA1 and BRCA2 carriers.
Neuhausen SL, Brummel S, Ding YC, Steele L, Nathanson KL, Domchek S, Rebbeck TR, Singer CF, Pfeiler G, Lynch HT, Garber JE, Couch F, Weitzel JN, Godwin A, Narod SA, Ganz PA, Daly MB, Isaacs C, Olopade OI, Tomlinson GE, Rubinstein WS, Tung N, Blum JL, Gillen DL
Cancer Epidemiol Biomarkers Prev. 2011
PubMed ID: 21708937
BRCA1 loss induces GADD153-mediated doxorubicin resistance in prostate cancer.
De Luca P, Vazquez ES, Moiola CP, Zalazar F, Cotignola J, Gueron G, Gardner K, De Siervi A
Mol Cancer Res. 2011
PubMed ID: 21700680
KIAA0101 interacts with BRCA1 and regulates centrosome number.
Kais Z, Barsky SH, Mathsyaraja H, Zha A, Ransburgh DJ, He G, Pilarski RT, Shapiro CL, Huang K, Parvin JD
Mol Cancer Res. 2011
PubMed ID: 21673012
Hypoxia-induced epigenetic regulation and silencing of the BRCA1 promoter.
Lu Y, Chu A, Turker MS, Glazer PM
Mol Cell Biol. 2011
PubMed ID: 21670155
Prevalence of BRCA1 and BRCA2 mutations in triple negative breast cancer.
Evans DG, Howell A, Ward D, Lalloo F, Jones JL, Eccles DM
J Med Genet. 2011
PubMed ID: 21653198
BRCA1 is a new MITF target gene.
Beuret L, Ohanna M, Strub T, Allegra M, Davidson I, Bertolotto C, Ballotti R
Pigment Cell Melanoma Res. 2011
PubMed ID: 21501420
Peripheral blood DNA methylation detected in the BRCA1 or BRCA2 promoter for sporadic ovarian cancer patients and controls.
Bosviel R, Michard E, Lavediaux G, Kwiatkowski F, Bignon YJ, Bernard-Gallon DJ
Clin Chim Acta. 2011
PubMed ID: 21557934
Risk-reducing salpingo-oophorectomy (RRSO) in BRCA mutation carriers: experience with a consecutive series of 111 patients using a standardized surgical-pathological protocol.
Powell CB, Chen LM, McLennan J, Crawford B, Zaloudek C, Rabban JT, Moore DH, Ziegler J
Int J Gynecol Cancer. 2011
PubMed ID: 21670699
Assessment of the prevalence of de novo mutations in the BRCA1 and BRCA2 genes.
Zhang L, Fleischut MH, Kohut K, Spencer S, Wong K, Stadler ZK, Kauff ND, Offit K, Robson ME
Clin Genet. 2011
PubMed ID: 21649643
Methylation-related mutations in the BRCA1 promoter in peripheral blood cells from cancer-free women.
Al-Moghrabi N, Al-Qasem AJ, Aboussekhra A
Int J Oncol. 2011
PubMed ID: 21537840
Assessment of rare BRCA1 and BRCA2 variants of unknown significance using hierarchical modeling.
Capanu M, Concannon P, Haile RW, Bernstein L, Malone KE, Lynch CF, Liang X, Teraoka SN, Diep AT, Thomas DC, Bernstein JL, WECARE Study Collaborative Group, Begg CB
Genet Epidemiol. 2011
PubMed ID: 21520273
Detoxification: a novel function of BRCA1 in tumor suppression?
Kang HJ, Hong YB, Kim HJ, Rodriguez OC, Nath RG, Tilli EM, Albanese C, Chung FL, Kwon SH, Bae I
Toxicol Sci. 2011
PubMed ID: 21507987
The impact of contralateral mastectomy on mortality in BRCA1 and BRCA2 mutation carriers with breast cancer.
Narod SA
Breast Cancer Res Treat. 2011
PubMed ID: 21455666
BRCA1 and BRCA2 germline mutations in Uruguayan breast and breast-ovarian cancer families. Identification of novel mutations and unclassified variants.
Delgado L, Fernández G, Grotiuz G, Cataldi S, González A, Lluveras N, Heguaburu M, Fresco R, Lens D, Sabini G, Muse IM
Breast Cancer Res Treat. 2011
PubMed ID: 21190077
An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients.
Vollebergh MA, Lips EH, Nederlof PM, Wessels LF, Schmidt MK, van Beers EH, Cornelissen S, Holtkamp M, Froklage FE, de Vries EG, Schrama JG, Wesseling J, van de Vijver MJ, van Tinteren H, de Bruin M, Hauptmann M, Rodenhuis S, Linn SC
Ann Oncol. 2011
PubMed ID: 21135055
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
A novel de novo BRCA1 mutation in a Chinese woman with early onset breast cancer.
Kwong A, Ng EK, Tang EY, Wong CL, Law FB, Leung CP, Chan A, Cheung MT, To MY, Ma ES, West DW, Ford JM
Fam Cancer. 2011
PubMed ID: 21404118
Splicing and multifactorial analysis of intronic BRCA1 and BRCA2 sequence variants identifies clinically significant splicing aberrations up to 12 nucleotides from the intron/exon boundary.
Whiley PJ, Guidugli L, Walker LC, Healey S, Thompson BA, Lakhani SR, Da Silva LM, kConFab Investigators, Tavtigian SV, Goldgar DE, Brown MA, Couch FJ, Spurdle AB
Hum Mutat. 2011
PubMed ID: 21394826
Screening of 1331 Danish breast and/or ovarian cancer families identified 40 novel BRCA1 and BRCA2 mutations.
Hansen TV, Jønson L, Steffensen AY, Andersen MK, Kjaergaard S, Gerdes AM, Ejlertsen B, Nielsen FC
Fam Cancer. 2011
PubMed ID: 21318380
Risk of contralateral breast cancer associated with common variants in BRCA1 and BRCA2: potential modifying effect of BRCA1/BRCA2 mutation carrier status.
Figueiredo JC, Brooks JD, Conti DV, Poynter JN, Teraoka SN, Malone KE, Bernstein L, Lee WD, Duggan DJ, Siniard A, Concannon P, Capanu M, Lynch CF, Olsen JH, Haile RW, Bernstein JL
Breast Cancer Res Treat. 2011
PubMed ID: 21161372
Germline mutations in BRCA1 and BRCA2 genes in ethnically diverse high risk families in Israel.
Laitman Y, Borsthein RT, Stoppa-Lyonnet D, Dagan E, Castera L, Goislard M, Gershoni-Baruch R, Goldberg H, Kaufman B, Ben-Baruch N, Zidan J, Maray T, Soussan-Gutman L, Friedman E
Breast Cancer Res Treat. 2011
PubMed ID: 20960228
Microcephalin is a new novel prognostic indicator in breast cancer associated with BRCA1 inactivation.
Richardson J, Shaaban AM, Kamal M, Alisary R, Walker C, Ellis IO, Speirs V, Green AR, Bell SM
Breast Cancer Res Treat. 2011
PubMed ID: 20632086
Impact of BRCA1 BRCT domain missense substitutions on phosphopeptide recognition.
Coquelle N, Green R, Glover JN
Biochemistry. 2011
PubMed ID: 21473589
Targeting the Akt/mTOR pathway in Brca1-deficient cancers.
Xiang T, Jia Y, Sherris D, Li S, Wang H, Lu D, Yang Q
Oncogene. 2011
PubMed ID: 21242970
Bcl-2 inhibits nuclear homologous recombination by localizing BRCA1 to the endomembranes.
Laulier C, Barascu A, Guirouilh-Barbat J, Pennarun G, Le Chalony C, Chevalier F, Palierne G, Bertrand P, Verbavatz JM, Lopez BS
Cancer Res. 2011
PubMed ID: 21444675
Mutations in the BRCT binding site of BRCA1 result in hyper-recombination.
Dever SM, Golding SE, Rosenberg E, Adams BR, Idowu MO, Quillin JM, Valerie N, Xu B, Povirk LF, Valerie K
Aging (Albany NY). 2011
PubMed ID: 21666281
CpG island hypermethylation of BRCA1 and loss of pRb as co-occurring events in basal/triple-negative breast cancer.
Stefansson OA, Jonasson JG, Olafsdottir K, Hilmarsdottir H, Olafsdottir G, Esteller M, Johannsson OT, Eyfjord JE
Epigenetics. 2011
PubMed ID: 21593597
BRCA1 counteracts progesterone action by ubiquitination leading to progesterone receptor degradation and epigenetic silencing of target promoters.
Calvo V, Beato M
Cancer Res. 2011
PubMed ID: 21531767
Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.
Daniel K, Lange J, Hached K, Fu J, Anastassiadis K, Roig I, Cooke HJ, Stewart AF, Wassmann K, Jasin M, Keeney S, Tóth A
Nat Cell Biol. 2011
PubMed ID: 21478856
Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers.
Garcia AI, Buisson M, Bertrand P, Rimokh R, Rouleau E, Lopez BS, Lidereau R, Mikaélian I, Mazoyer S
EMBO Mol Med. 2011
PubMed ID: 21472990
Mutational screening of the BRCA1 gene in sporadic breast cancer in Kazakhstan population.
Akilzhanova A, Meirmanov S, Zhunussova T, Nakashima M, Takamura N, Akanov Z, Masadykov A, Sandybaev M, Ramanulov E, Yamashita S, Sekine I
Breast J. 2011
PubMed ID: 21410590
CDC25A, VAV1, TP73, BRCA1 and ZAP70 gene overexpression correlates with radiation response in colorectal cancer.
Huang MY, Wang JY, Chang HJ, Kuo CW, Tok TS, Lin SR
Oncol Rep. 2011
PubMed ID: 21344162
Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer.
Zhang S, Royer R, Li S, McLaughlin JR, Rosen B, Risch HA, Fan I, Bradley L, Shaw PA, Narod SA
Gynecol Oncol. 2011
PubMed ID: 21324516
Improved survival in non-Ashkenazi Jewish ovarian cancer patients with BRCA1 and BRCA2 gene mutations.
Lacour RA, Westin SN, Meyer LA, Wingo SN, Schorge JO, Brooks R, Mutch D, Molina A, Sutphen R, Barnes M, Elder J, Teoh D, Powell CB, Choubey V, Blank S, Macdonald HR, Brady MF, Urbauer DL, Bodurka D, Gershenson DM, Lu KH
Gynecol Oncol. 2011
PubMed ID: 21276604
Risk of ipsilateral breast cancer in BRCA1 and BRCA2 mutation carriers.
Metcalfe K, Lynch HT, Ghadirian P, Tung N, Kim-Sing C, Olopade OI, Domchek S, Eisen A, Foulkes WD, Rosen B, Vesprini D, Sun P, Narod SA
Breast Cancer Res Treat. 2011
PubMed ID: 21221768
Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations.
Dedes KJ, Wilkerson PM, Wetterskog D, Weigelt B, Ashworth A, Reis-Filho JS
Cell Cycle. 2011
PubMed ID: 21487248
The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection.
Coleman KA, Greenberg RA
J Biol Chem. 2011
PubMed ID: 21335604
Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2.
Osorio A, Milne RL, Alonso R, Pita G, Peterlongo P, Teulé A, Nathanson KL, Domchek SM, Rebbeck T, Lasa A, Konstantopoulou I, Hogervorst FB, Verhoef S, van Dooren MF, Jager A, Ausems MG, Aalfs CM, van Asperen CJ, Vreeswijk M, Waisfisz Q, Van Roozendaal CE, Ligtenberg MJ, HEBON, EMBRACE, Easton DF, Peock S, Cook M, Oliver CT, Frost D, Curzon B, Evans DG, Lalloo F, Eeles R, Izatt L, Davidson R, Adlard J, Eccles D, Ong KR, Douglas F, Downing S, Brewer C, Walker L, Nevanlinna H, Aittomäki K, Couch FJ, Fredericksen Z, Lindor NM, Godwin A, Isaacs C, Caligo MA, Loman N, Jernström H, Barbany-Bustinza G, Liljegren A, Ehrencrona H, Stenmark-Askmalm M, Sw E-BRCA, Feliubadaló L, Manoukian S, Peissel B, Zaffaroni D, Bonanni B, Fortuzzi S, Johannsson OT, Chenevix-Trench G, Chen XC, Beesley J, Spurdle AB, kConFab, Sinilnikova OM, Healey S, McGuffog L, Antoniou AC, Brunet J, Radice P, Benítez J, CIMBA
Br J Cancer. 2011
PubMed ID: 21427728
Multifunctional transcription factor TFII-I is an activator of BRCA1 function.
Tanikawa M, Wada-Hiraike O, Nakagawa S, Shirane A, Hiraike H, Koyama S, Miyamoto Y, Sone K, Tsuruga T, Nagasaka K, Matsumoto Y, Ikeda Y, Shoji K, Oda K, Fukuhara H, Nakagawa K, Kato S, Yano T, Taketani Y
Br J Cancer. 2011
PubMed ID: 21407215
Report of Endometrial Cancer in Australian BRCA1 and BRCA2 mutation-positive Families.
Duffy DL, Antill YC, Stewart CJ, Young JP, kConFab, Spurdle AB
Twin Res Hum Genet. 2011
PubMed ID: 21425892
RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci.
Hu Y, Scully R, Sobhian B, Xie A, Shestakova E, Livingston DM
Genes Dev. 2011
PubMed ID: 21406551
Pathology of hereditary breast cancer.
van der Groep P, van der Wall E, van Diest PJ
Cell Oncol (Dordr). 2011
PubMed ID: 21336636
Prediction of single-nucleotide substitutions that result in exon skipping: identification of a splicing silencer in BRCA1 exon 6.
Raponi M, Kralovicova J, Copson E, Divina P, Eccles D, Johnson P, Baralle D, Vorechovsky I
Hum Mutat. 2011
PubMed ID: 21309043
NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes.
Hu X, Kim JA, Castillo A, Huang M, Liu J, Wang B
J Biol Chem. 2011
PubMed ID: 21282113
Cell cycle-dependent conjugation of endogenous BRCA1 protein with SUMO-2/3.
Vialter A, Vincent A, Demidem A, Morvan D, Stepien G, Venezia ND, Rio PG
Biochim Biophys Acta. 2011
PubMed ID: 21147198
Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit.
Smart CE, Wronski A, French JD, Edwards SL, Asselin-Labat ML, Waddell N, Peters K, Brewster BL, Brooks K, Simpson K, Manning N, Lakhani SR, Grimmond S, Lindeman GJ, Visvader JE, Brown MA
Oncogene. 2011
PubMed ID: 21132007
Evolutionary dynamics of BRCA1 alterations in breast tumorigenesis.
De Vargas Roditi L, Michor F
J Theor Biol. 2011
PubMed ID: 21194536
Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer.
Gonzalez ME, DuPrie ML, Krueger H, Merajver SD, Ventura AC, Toy KA, Kleer CG
Cancer Res. 2011
PubMed ID: 21406404
Morphological predictors of BRCA1 germline mutations in young women with breast cancer.
Southey MC, Ramus SJ, Dowty JG, Smith LD, Tesoriero AA, Wong EE, Dite GS, Jenkins MA, Byrnes GB, Winship I, Phillips KA, Giles GG, Hopper JL
Br J Cancer. 2011
PubMed ID: 21343941
Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice.
Burga LN, Hu H, Juvekar A, Tung NM, Troyan SL, Hofstatter EW, Wulf GM
Breast Cancer Res. 2011
PubMed ID: 21396117
The expression of ERCC1, RRM1, and BRCA1 in breast cancer according to the immunohistochemical phenotypes.
Kim D, Jung W, Koo JS
J Korean Med Sci. 2011
PubMed ID: 21394302
The DeltaNp63 proteins are key allies of BRCA1 in the prevention of basal-like breast cancer.
Buckley NE, Conlon SJ, Jirstrom K, Kay EW, Crawford NT, O'Grady A, Sheehan K, Mc Dade SS, Wang CW, McCance DJ, Johnston PG, Kennedy RD, Harkin DP, Mullan PB
Cancer Res. 2011
PubMed ID: 21363924
Expression of excision repair cross-complementation group 1, breast cancer susceptibility 1, and β III-tubulin in thymic epithelial tumors.
Kaira K, Serizawa M, Koh Y, Miura S, Kaira R, Abe M, Nakagawa K, Ohde Y, Okumura T, Naito T, Murakami H, Takahashi T, Kondo H, Nakajima T, Endo M, Yamamoto N
J Thorac Oncol. 2011
PubMed ID: 21289518
Microscopic and early-stage ovarian cancers in BRCA1/2 mutation carriers: building a model for early BRCA-associated tumorigenesis.
Yates MS, Meyer LA, Deavers MT, Daniels MS, Keeler ER, Mok SC, Gershenson DM, Lu KH
Cancer Prev Res (Phila). 2011
PubMed ID: 21278312
On the origin and diffusion of BRCA1 c.5266dupC (5382insC) in European populations.
Hamel N, Feng BJ, Foretova L, Stoppa-Lyonnet D, Narod SA, Imyanitov E, Sinilnikova O, Tihomirova L, Lubinski J, Gronwald J, Gorski B, Hansen TO, Nielsen FC, Thomassen M, Yannoukakos D, Konstantopoulou I, Zajac V, Ciernikova S, Couch FJ, Greenwood CM, Goldgar DE, Foulkes WD
Eur J Hum Genet. 2011
PubMed ID: 21119707
Two BRCA1/2 founder mutations in Jews of Sephardic origin.
Sagi M, Eilat A, Ben Avi L, Goldberg Y, Bercovich D, Hamburger T, Peretz T, Lerer I
Fam Cancer. 2011
PubMed ID: 21063910
Breast cancer surgery trend changes since the introduction of BRCA1/2 mutation screening: a retrospective cohort analysis of 158 mutation carriers treated at a single institution.
Mislowsky A, Domchek S, Stroede C, Bergey MR, Sonnad SS, Wu L, Tchou J
Ann Surg Oncol. 2011
PubMed ID: 20972632
An exploration of the communication preferences regarding genetic testing in individuals from families with identified breast/ovarian cancer mutations.
Ratnayake P, Wakefield CE, Meiser B, Suthers G, Price MA, Duffy J, Kathleen Cuningham National Consortium for Research into Familial Breast Cancer, Tucker K
Fam Cancer. 2011
PubMed ID: 20878485
Cancer-specific methylation in the BRCA1 promoter in sporadic breast tumours.
Ali AB, Iau PT, Sng JH
Med Oncol. 2011
PubMed ID: 20135363
Coexpression of the mutated BRCA1 mRNA and p53 mRNA and its association in Chinese prostate cancer.
Ding GF, Xu YF, Yang ZS, Ding YL, Fang HF, Zhao HP
Urol Oncol. 2011
PubMed ID: 19269198
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome.
Suhasini AN, Rawtani NA, Wu Y, Sommers JA, Sharma S, Mosedale G, North PS, Cantor SB, Hickson ID, Brosh RM
EMBO J. 2011
PubMed ID: 21240188
A novel role for BRCA1 in regulating breast cancer cell spreading and motility.
Coene ED, Gadelha C, White N, Malhas A, Thomas B, Shaw M, Vaux DJ
J Cell Biol. 2011
PubMed ID: 21282464
Expression of the stem cell marker ALDH1 in BRCA1 related breast cancer.
Heerma van Voss MR, van der Groep P, Bart J, van der Wall E, van Diest PJ
Cell Oncol (Dordr). 2011
PubMed ID: 21336637
BRCA1 suppresses the expression of survivin and promotes sensitivity to paclitaxel through the calcium sensing receptor (CaSR) in human breast cancer cells.
Promkan M, Liu G, Patmasiriwat P, Chakrabarty S
Cell Calcium. 2011
PubMed ID: 21296416
Genomic signature of BRCA1 deficiency in sporadic basal-like breast tumors.
Joosse SA, Brandwijk KI, Mulder L, Wesseling J, Hannemann J, Nederlof PM
Genes Chromosomes Cancer. 2011
PubMed ID: 21104783
Two novel variants in the 3'UTR of the BRCA1 gene in familial breast and/or ovarian cancer.
Lheureux S, Lambert B, Krieger S, Legros A, Vaur D, Denoyelle C, Berthet P, Poulain L, Hardouin A
Breast Cancer Res Treat. 2011
PubMed ID: 20848184
Comparative effectiveness of screening and prevention strategies among BRCA1/2-affected mutation carriers.
Grann VR, Patel PR, Jacobson JS, Warner E, Heitjan DF, Ashby-Thompson M, Hershman DL, Neugut AI
Breast Cancer Res Treat. 2011
PubMed ID: 20644999
Involvement of MyoD and c-myb in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene.
Jin W, Liu Y, Chen L, Zhu H, Di GH, Ling H, Wu J, Shao ZM
Breast Cancer Res Treat. 2011
PubMed ID: 20364308
Correlation of BRCA1, TXR1 and TSP1 mRNA expression with treatment outcome to docetaxel-based first-line chemotherapy in patients with advanced/metastatic non-small-cell lung cancer.
Papadaki C, Tsaroucha E, Kaklamanis L, Lagoudaki E, Trypaki M, Tryfonidis K, Mavroudis D, Stathopoulos E, Georgoulias V, Souglakos J
Br J Cancer. 2011
PubMed ID: 21157449
Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation.
Lee YH, Bedford MT, Stallcup MR
Genes Dev. 2011
PubMed ID: 21245169
Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells.
Goldberg MS, Xing D, Ren Y, Orsulic S, Bhatia SN, Sharp PA
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21187397
Genotype-phenotype correlations among BRCA1 4153delA and 5382insC mutation carriers from Latvia.
Plakhins G, Irmejs A, Gardovskis A, Subatniece S, Rozite S, Bitina M, Keire G, Purkalne G, Teibe U, Trofimovics G, Miklasevics E, Gardovskis J
BMC Med Genet. 2011
PubMed ID: 22032251
Human BRCA1-associated breast cancer: no increase in numerical chromosomal instability compared to sporadic tumors.
Focken T, Steinemann D, Skawran B, Hofmann W, Ahrens P, Arnold N, Kroll P, Kreipe H, Schlegelberger B, Gadzicki D
Cytogenet Genome Res. 2011
PubMed ID: 22024613
A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer.
Garcia-Casado Z, Romero I, Fernandez-Serra A, Rubio L, Llopis F, Garcia A, Llombart P, Lopez-Guerrero JA
BMC Med Genet. 2011
PubMed ID: 21989022
Regulation of the BRCA1 gene by an SRC3/53BP1 complex.
Corkery D, Thillainadesan G, Coughlan N, Mohan RD, Isovic M, Tini M, Torchia J
BMC Biochem. 2011
PubMed ID: 21914189
Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast cancer risk.
Ricks-Santi LJ, Sucheston LE, Yang Y, Freudenheim JL, Isaacs CJ, Schwartz MD, Dumitrescu RG, Marian C, Nie J, Vito D, Edge SB, Shields PG
BMC Cancer. 2011
PubMed ID: 21708019
c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells.
Chen Y, Xu J, Borowicz S, Collins C, Huo D, Olopade OI
BMC Cancer. 2011
PubMed ID: 21668996
A structural bioinformatics approach to explore the interactions of P53 and BRCA1 gene products on ovarian and breast cancer.
Parija S, Kumar A
Int J Bioinform Res Appl. 2011
PubMed ID: 21441093
BRCA1/2 status and clinicopathologic characteristics of patients with double primary breast and ovarian cancer.
Cvelbar M, Hocevar M, Vidmar G, Teugels E
Neoplasma. 2011
PubMed ID: 21391735
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
The occurrence of germline BRCA1 and BRCA2 sequence alterations in Slovenian population.
Stegel V, Krajc M, Zgajnar J, Teugels E, De Grève J, Hočevar M, Novaković S
BMC Med Genet. 2011
PubMed ID: 21232165
BRCA1-related gene signature in breast cancer: the role of ER status and molecular type.
Lisowska KM, Dudaladava V, Jarzab M, Huzarski T, Chmielik E, Stobiecka E, Lubinski J, Jarzab B
Front Biosci (Elite Ed). 2011
PubMed ID: 21196292
Rare BRCA1 haplotypes including 3'UTR SNPs associated with breast cancer risk.
Pelletier C, Speed WC, Paranjape T, Keane K, Blitzblau R, Hollestelle A, Safavi K, van den Ouweland A, Zelterman D, Slack FJ, Kidd KK, Weidhaas JB
Cell Cycle. 2011
PubMed ID: 21191178
Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer.
Villarroel MC, Rajeshkumar NV, Garrido-Laguna I, De Jesus-Acosta A, Jones S, Maitra A, Hruban RH, Eshleman JR, Klein A, Laheru D, Donehower R, Hidalgo M
Mol Cancer Ther. 2011
PubMed ID: 21135251
Allelic imbalance in BRCA1 and BRCA2 gene expression and familial ovarian cancer.
Shen J, Medico L, Zhao H
Cancer Epidemiol Biomarkers Prev. 2011
PubMed ID: 21119070
Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer.
Wong EM, Southey MC, Fox SB, Brown MA, Dowty JG, Jenkins MA, Giles GG, Hopper JL, Dobrovic A
Cancer Prev Res (Phila). 2011
PubMed ID: 20978112
Genomic large rearrangement screening of BRCA1 and BRCA2 genes in high-risk Turkish breast/ovarian cancer patients by using multiplex ligation-dependent probe amplification assay.
Manguoğlu E, Güran S, Yamaç D, Simşek M, Akdeniz S, Colak T, Gülkesen H, Lüleci G
Cancer Invest. 2011
PubMed ID: 20919953
Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study.
Mitra AV, Bancroft EK, Barbachano Y, Page EC, Foster CS, Jameson C, Mitchell G, Lindeman GJ, Stapleton A, Suthers G, Evans DG, Cruger D, Blanco I, Mercer C, Kirk J, Maehle L, Hodgson S, Walker L, Izatt L, Douglas F, Tucker K, Dorkins H, Clowes V, Male A, Donaldson A, Brewer C, Doherty R, Bulman B, Osther PJ, Salinas M, Eccles D, Axcrona K, Jobson I, Newcombe B, Cybulski C, Rubinstein WS, Buys S, Townshend S, Friedman E, Domchek S, Ramon Y Cajal T, Spigelman A, Teo SH, Nicolai N, Aaronson N, Ardern-Jones A, Bangma C, Dearnaley D, Eyfjord J, Falconer A, Grönberg H, Hamdy F, Johannsson O, Khoo V, Kote-Jarai Z, Lilja H, Lubinski J, Melia J, Moynihan C, Peock S, Rennert G, Schröder F, Sibley P, Suri M, Wilson P, Bignon YJ, Strom S, Tischkowitz M, Liljegren A, Ilencikova D, Abele A, Kyriacou K, van Asperen C, Kiemeney L, IMPACT Study Collaborators, Easton DF, Eeles RA
BJU Int. 2011
PubMed ID: 20840664
A high prevalence of BRCA1 mutations among breast cancer patients from the Bahamas.
Donenberg T, Lunn J, Curling D, Turnquest T, Krill-Jackson E, Royer R, Narod SA, Hurley J
Breast Cancer Res Treat. 2011
PubMed ID: 20838878
A recombination-based method to characterize human BRCA1 missense variants.
Guidugli L, Rugani C, Lombardi G, Aretini P, Galli A, Caligo MA
Breast Cancer Res Treat. 2011
PubMed ID: 20737206
No evidence of excess breast cancer risk among mutation-negative women from BRCA mutation-positive families.
Korde LA, Mueller CM, Loud JT, Struewing JP, Nichols K, Greene MH, Mai PL
Breast Cancer Res Treat. 2011
PubMed ID: 20458532
Large genomic rearrangements of the BRCA1 and BRCA2 genes: review of the literature and report of a novel BRCA1 mutation.
Sluiter MD, van Rensburg EJ
Breast Cancer Res Treat. 2011
PubMed ID: 20232141
Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1.
Deng Y, Liu J, Han G, Lu SL, Wang SY, Malkoski S, Tan AC, Deng C, Wang XJ, Zhang Q
Oncogene. 2010
PubMed ID: 20818429
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.
Dynek JN, Goncharov T, Dueber EC, Fedorova AV, Izrael-Tomasevic A, Phu L, Helgason E, Fairbrother WJ, Deshayes K, Kirkpatrick DS, Vucic D
EMBO J. 2010
PubMed ID: 21113135
Non-founder BRCA1 mutations in Russian breast cancer patients.
Iyevleva AG, Suspitsin EN, Kroeze K, Gorodnova TV, Sokolenko AP, Buslov KG, Voskresenskiy DA, Togo AV, Kovalenko SP, Stoep N, Devilee P, Imyanitov EN
Cancer Lett. 2010
PubMed ID: 20727672
AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers.
Guirouilh-Barbat JK, Wilhelm T, Lopez BS
Oncotarget. 2010
PubMed ID: 21321378
Identification of a preneoplastic gene expression profile in tubal epithelium of BRCA1 mutation carriers.
Press JZ, Wurz K, Norquist BM, Lee MK, Pennil C, Garcia R, Welcsh P, Goff BA, Swisher EM
Neoplasia. 2010
PubMed ID: 21170264
Germline mutations of BRCA1 and BRCA2 genes in Turkish breast, ovarian, and prostate cancer patients.
Manguoğlu E, Güran S, Yamaç D, Colak T, Simşek M, Baykara M, Akaydın M, Lüleci G
Cancer Genet Cytogenet. 2010
PubMed ID: 21156238
Prevalence of BRCA1 and BRCA2 mutations in women with breast carcinoma In Situ and referred for genetic testing.
Hall MJ, Reid JE, Wenstrup RJ
Cancer Prev Res (Phila). 2010
PubMed ID: 21149333
Identification and Management of Women With BRCA Mutations or Hereditary Predisposition for Breast and Ovarian Cancer.
Pruthi S, Gostout BS, Lindor NM
Mayo Clin Proc. 2010
PubMed ID: 21123638
BRCA germline mutations in women with uterine serous carcinoma--still a debate.
Lavie O, Ben-Arie A, Segev Y, Faro J, Barak F, Haya N, Auslender R, Gemer O
Int J Gynecol Cancer. 2010
PubMed ID: 21119368
Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction.
Antoniou AC, Beesley J, McGuffog L, Sinilnikova OM, Healey S, Neuhausen SL, Ding YC, Rebbeck TR, Weitzel JN, Lynch HT, Isaacs C, Ganz PA, Tomlinson G, Olopade OI, Couch FJ, Wang X, Lindor NM, Pankratz VS, Radice P, Manoukian S, Peissel B, Zaffaroni D, Barile M, Viel A, Allavena A, Dall'Olio V, Peterlongo P, Szabo CI, Zikan M, Claes K, Poppe B, Foretova L, Mai PL, Greene MH, Rennert G, Lejbkowicz F, Glendon G, Ozcelik H, Andrulis IL, Ontario Cancer Genetics Network, Thomassen M, Gerdes AM, Sunde L, Cruger D, Birk Jensen U, Caligo M, Friedman E, Kaufman B, Laitman Y, Milgrom R, Dubrovsky M, Cohen S, Borg A, Jernström H, Lindblom A, Rantala J, Stenmark-Askmalm M, Melin B, SWE-BRCA, Nathanson K, Domchek S, Jakubowska A, Lubinski J, Huzarski T, Osorio A, Lasa A, Durán M, Tejada MI, Godino J, Benitez J, Hamann U, Kriege M, Hoogerbrugge N, van der Luijt RB, van Asperen CJ, Devilee P, Meijers-Heijboer EJ, Blok MJ, Aalfs CM, Hogervorst F, Rookus M, HEBON, Cook M, Oliver C, Frost D, Conroy D, Evans DG, Lalloo F, Pichert G, Davidson R, Cole T, Cook J, Paterson J, Hodgson S, Morrison PJ, Porteous ME, Walker L, Kennedy MJ, Dorkins H, Peock S, EMBRACE, Godwin AK, Stoppa-Lyonnet D, de Pauw A, Mazoyer S, Bonadona V, Lasset C, Dreyfus H, Leroux D, Hardouin A, Berthet P, Faivre L, GEMO, Loustalot C, Noguchi T, Sobol H, Rouleau E, Nogues C, Frénay M, Vénat-Bouvet L, GEMO, Hopper JL, Daly MB, Terry MB, John EM, Buys SS, Yassin Y, Miron A, Goldgar D, Breast Cancer Family Registry, Singer CF, Dressler AC, Gschwantler-Kaulich D, Pfeiler G, Hansen TV, Jønson L, Agnarsson BA, Kirchhoff T, Offit K, Devlin V, Dutra-Clarke A, Piedmonte M, Rodriguez GC, Wakeley K, Boggess JF, Basil J, Schwartz PE, Blank SV, Toland AE, Montagna M, Casella C, Imyanitov E, Tihomirova L, Blanco I, Lazaro C, Ramus SJ, Sucheston L, Karlan BY, Gross J, Schmutzler R, Wappenschmidt B, Engel C, Meindl A, Lochmann M, Arnold N, Heidemann S, Varon-Mateeva R, Niederacher D, Sutter C, Deissler H, Gadzicki D, Preisler-Adams S, Kast K, Schönbuchner I, Caldes T, de la Hoya M, Aittomäki K, Nevanlinna H, Simard J, Spurdle AB, Holland H, Chen X, kConFab, Platte R, Chenevix-Trench G, Easton DF, CIMBA
Cancer Res. 2010
PubMed ID: 21118973
Conditional knockout of brca1/2 and p53 in mouse ovarian surface epithelium: do they play a role in ovarian carcinogenesis?
Kim KY, Park DW, Jeung EB, Choi KC
J Vet Sci. 2010
PubMed ID: 21113097
Transcriptional regulation of BRCA1 expression by a metabolic switch.
Di LJ, Fernandez AG, De Siervi A, Longo DL, Gardner K
Nat Struct Mol Biol. 2010
PubMed ID: 21102443
BRCA1 modulates the expression of hnRNPA2B1 and KHSRP.
Santarosa M, Del Col L, Viel A, Bivi N, D'Ambrosio C, Scaloni A, Tell G, Maestro R
Cell Cycle. 2010
PubMed ID: 21099359
BRCA1 and BRCA2 genetic test in high risk patients and families: counselling and management.
Marchina E, Fontana MG, Speziani M, Salvi A, Ricca G, Di Lorenzo D, Gervasi M, Caimi L, Barlati S
Oncol Rep. 2010
PubMed ID: 21042765
BRCA1 and BRCA2 heterozygosity in embryonic stem cells reduces radiation-induced Rad51 focus formation but is not associated with radiosensitivity.
Sioftanos G, Ismail A, Föhse L, Shanley S, Worku M, Short SC
Int J Radiat Biol. 2010
PubMed ID: 20979543
BRCA1 mutations and colorectal cancer in Poland.
Suchy J, Cybulski C, Górski B, Huzarski T, Byrski T, Dębniak T, Gronwald J, Jakubowska A, Wokołorczyk D, Kurzawski G, Kładny J, Jawień A, Banaszkiewicz Z, Wiśniowski R, Wandzel P, Starzewski J, Lorenc Z, Korobowicz E, Krokowicz P, Horbacka K, Lubiński J, Narod SA
Fam Cancer. 2010
PubMed ID: 20862552
The rate of the predominant Jewish mutations in the BRCA1, BRCA2, MSH2 and MSH6 genes in unselected Jewish endometrial cancer patients.
Barak F, Milgrom R, Laitman Y, Gemer O, Rabinovich A, Piura B, Anteby E, Baruch GB, Korach J, Friedman E
Gynecol Oncol. 2010
PubMed ID: 20850175
Contribution of CDKN2A/P16 ( INK4A ), P14 (ARF), CDK4 and BRCA1/2 germline mutations in individuals with suspected genetic predisposition to uveal melanoma.
Buecher B, Gauthier-Villars M, Desjardins L, Lumbroso-Le Rouic L, Levy C, De Pauw A, Bombled J, Tirapo C, Houdayer C, Bressac-de Paillerets B, Stoppa-Lyonnet D
Fam Cancer. 2010
PubMed ID: 20842456
BRCA1 and BRCA2 families and the risk of skin cancer.
Ginsburg OM, Kim-Sing C, Foulkes WD, Ghadirian P, Lynch HT, Sun P, Narod SA, Hereditary Breast Cancer Clinical Study Group
Fam Cancer. 2010
PubMed ID: 20809262
Comprehensive BRCA1 and BRCA2 mutation analyses and review of French Canadian families with at least three cases of breast cancer.
Cavallone L, Arcand SL, Maugard CM, Nolet S, Gaboury LA, Mes-Masson AM, Ghadirian P, Provencher D, Tonin PN
Fam Cancer. 2010
PubMed ID: 20694749
Complete BRCA mutation screening in breast and ovarian cancer predisposition families from a North-Eastern Romanian population.
Negura L, Uhrhammer N, Negura A, Artenie V, Carasevici E, Bignon YJ
Fam Cancer. 2010
PubMed ID: 20567915
Predicting BRCA1 and BRCA2 gene mutation carriers: comparison of PENN II model to previous study.
Lindor NM, Johnson KJ, Harvey H, Shane Pankratz V, Domchek SM, Hunt K, Wilson M, Cathie Smith M, Couch F
Fam Cancer. 2010
PubMed ID: 20512419
BRCA1/2 test results impact risk management attitudes, intentions, and uptake.
O'Neill SC, Valdimarsdottir HB, Demarco TA, Peshkin BN, Graves KD, Brown K, Hurley KE, Isaacs C, Hecker S, Schwartz MD
Breast Cancer Res Treat. 2010
PubMed ID: 20383578
BRCA1-Associated Breast Cancers Present Differently From BRCA2-Associated and Familial Cases: Long-Term Follow-Up of the Dutch MRISC Screening Study.
Rijnsburger AJ, Obdeijn IM, Kaas R, Tilanus-Linthorst MM, Boetes C, Loo CE, Wasser MN, Bergers E, Kok T, Muller SH, Peterse H, Tollenaar RA, Hoogerbrugge N, Meijer S, Bartels CC, Seynaeve C, Hooning MJ, Kriege M, Schmitz PI, Oosterwijk JC, de Koning HJ, Rutgers EJ, Klijn JG
J Clin Oncol. 2010
PubMed ID: 21079137
The molecular pathogenesis of hereditary ovarian carcinoma: alterations in the tubal epithelium of women with BRCA1 and BRCA2 mutations.
Norquist BM, Garcia RL, Allison KH, Jokinen CH, Kernochan LE, Pizzi CC, Barrow BJ, Goff BA, Swisher EM
Cancer. 2010
PubMed ID: 20665887
Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy cantonese.
Shen GP, Pan QH, Hong MH, Qin HD, Xu YF, Chen LZ, Feng QS, Jorgensen TJ, Shugart YY, Zeng YX, Jia WH
Int J Cancer. 2010
PubMed ID: 21077165
Diabetes and breast cancer among women with BRCA1 and BRCA2 mutations.
Bordeleau L, Lipscombe L, Lubinski J, Ghadirian P, Foulkes WD, Neuhausen S, Ainsworth P, Pollak M, Sun P, Narod SA, the Hereditary Breast Cancer Clinical Study Group
Cancer. 2010
PubMed ID: 21069710
BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions.
Hair JM, Terzoudi GI, Hatzi VI, Lehockey KA, Srivastava D, Wang W, Pantelias GE, Georgakilas AG
Chem Biol Interact. 2010
PubMed ID: 20371364
Association of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
Engel C, Versmold B, Wappenschmidt B, Simard J, Easton DF, Peock S, Cook M, Oliver C, Frost D, Mayes R, Evans DG, Eeles R, Paterson J, Brewer C, Epidemiological Study of Familial Breast Cancer (EMBRACE), McGuffog L, Antoniou AC, Stoppa-Lyonnet D, Sinilnikova OM, Barjhoux L, Frenay M, Michel C, Leroux D, Dreyfus H, Toulas C, Gladieff L, Uhrhammer N, Bignon YJ, Meindl A, Arnold N, Varon-Mateeva R, Niederacher D, Preisler-Adams S, Kast K, Deissler H, Sutter C, Gadzicki D, Chenevix-Trench G, Spurdle AB, Chen X, Beesley J, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Olsson H, Kristoffersson U, Ehrencrona H, Liljegren A, Swedish Breast Cancer Study, Sweden (SWE-BRCA), van der Luijt RB, van Os TA, van Leeuwen FE, Hereditary Breast and Ovarian cancer group Netherlands (HEBON), Domchek SM, Rebbeck TR, Nathanson KL, Osorio A, Ramón y Cajal T, Konstantopoulou I, Benítez J, Friedman E, Kaufman B, Laitman Y, Mai PL, Greene MH, Nevanlinna H, Aittomäki K, Szabo CI, Caldes T, Couch FJ, Andrulis IL, Godwin AK, Hamann U, Schmutzler RK, Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20978178
BRCA1-IRIS overexpression promotes cisplatin resistance in ovarian cancer cells.
Chock KL, Allison JM, Shimizu Y, ElShamy WM
Cancer Res. 2010
PubMed ID: 20940403
[Genes beyond BRCA1 and BRCA2 for hereditary breast cancer].
Simon K, Geigl JB, Pristauz G
Wien Med Wochenschr. 2010
PubMed ID: 20890790
BRCA1 affects global DNA methylation through regulation of DNMT1.
Shukla V, Coumoul X, Lahusen T, Wang RH, Xu X, Vassilopoulos A, Xiao C, Lee MH, Man YG, Ouchi M, Ouchi T, Deng CX
Cell Res. 2010
PubMed ID: 20820192
Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies.
Shen M, Menashe I, Morton LM, Zhang Y, Armstrong B, Wang SS, Lan Q, Hartge P, Purdue MP, Cerhan JR, Grulich A, Cozen W, Yeager M, Holford TR, Vajdic CM, Davis S, Leaderer B, Kricker A, Severson RK, Zahm SH, Chatterjee N, Rothman N, Chanock SJ, Zheng T
Br J Haematol. 2010
PubMed ID: 20813000
A critical re-appraisal of BRCA1 methylation studies in ovarian cancer.
Senturk E, Cohen S, Dottino PR, Martignetti JA
Gynecol Oncol. 2010
PubMed ID: 20797776
Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer.
Kim M, Kang HG, Lee SY, Lee HC, Lee EB, Choi YY, Lee WK, Cho S, Jin G, Jheon HS, Son JW, Lee MH, Jung DK, Cha SI, Kim CH, Kang YM, Kam S, Jung TH, Jheon S, Park JY
Cancer Sci. 2010
PubMed ID: 20731661
Large BRCA1 and BRCA2 genomic rearrangements in Malaysian high risk breast-ovarian cancer families.
Kang P, Mariapun S, Phuah SY, Lim LS, Liu J, Yoon SY, Thong MK, Mohd Taib NA, Yip CH, Teo SH
Breast Cancer Res Treat. 2010
PubMed ID: 20617377
Searching for large genomic rearrangements of the BRCA1 gene in a Nigerian population.
Zhang J, Fackenthal JD, Huo D, Zheng Y, Olopade OI
Breast Cancer Res Treat. 2010
PubMed ID: 20596889
Identification of a novel BRCA1 nucleotide 4803delCC/c.4684delCC mutation and a nucleotide 249T>A/c.130T>A (p.Cys44Ser) mutation in two Greenlandic Inuit families: implications for genetic screening of Greenlandic Inuit families with high risk for breast
Hansen TV, Jønson L, Albrechtsen A, Steffensen AY, Bergsten E, Myrhøj T, Ejlertsen B, Nielsen FC
Breast Cancer Res Treat. 2010
PubMed ID: 20437199
Four new cases of double heterozygosity for BRCA1 and BRCA2 gene mutations: clinical, pathological, and family characteristics.
Zuradelli M, Peissel B, Manoukian S, Zaffaroni D, Barile M, Pensotti V, Cavallari U, Masci G, Mariette F, Benski AC, Santoro A, Radice P
Breast Cancer Res Treat. 2010
PubMed ID: 20373018
Occult ovarian cancers identified at risk-reducing salpingo-oophorectomy in a prospective cohort of BRCA1/2 mutation carriers.
Domchek SM, Friebel TM, Garber JE, Isaacs C, Matloff E, Eeles R, Evans DG, Rubinstein W, Singer CF, Rubin S, Lynch HT, Daly MB, Weitzel J, Ganz PA, Pichert G, Olopade OI, Tomlinson G, Tung N, Blum JL, Couch F, Rebbeck TR
Breast Cancer Res Treat. 2010
PubMed ID: 20180014
Screening for genomic rearrangements in BRCA1 and BRCA2 genes in Czech high-risk breast/ovarian cancer patients: high proportion of population specific alterations in BRCA1 gene.
Ticha I, Kleibl Z, Stribrna J, Kotlas J, Zimovjanova M, Mateju M, Zikan M, Pohlreich P
Breast Cancer Res Treat. 2010
PubMed ID: 20135348
Double heterozygosity in the BRCA1 and BRCA2 genes in the Jewish population.
Lavie O, Narod S, Lejbkowicz F, Dishon S, Goldberg Y, Gemer O, Rennert G
Ann Oncol. 2010
PubMed ID: 20924075
The interplay between BRCA1 and 53BP1 influences death, aging, senescence and cancer.
Lowndes NF
DNA Repair (Amst). 2010
PubMed ID: 20724228
BRCA1/2 germline mutations in Jewish patients with uterine serous carcinoma.
Bruchim I, Amichay K, Kidron D, Attias Z, Biron-Shental T, Drucker L, Friedman E, Werner H, Fishman A
Int J Gynecol Cancer. 2010
PubMed ID: 21206239
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population.
Antoniou AC, Wang X, Fredericksen ZS, McGuffog L, Tarrell R, Sinilnikova OM, Healey S, Morrison J, Kartsonaki C, Lesnick T, Ghoussaini M, Barrowdale D, EMBRACE, Peock S, Cook M, Oliver C, Frost D, Eccles D, Evans DG, Eeles R, Izatt L, Chu C, Douglas F, Paterson J, Stoppa-Lyonnet D, Houdayer C, Mazoyer S, Giraud S, Lasset C, Remenieras A, Caron O, Hardouin A, Berthet P, GEMO Study Collaborators, Hogervorst FB, Rookus MA, Jager A, van den Ouweland A, Hoogerbrugge N, van der Luijt RB, Meijers-Heijboer H, Gómez García EB, HEBON, Devilee P, Vreeswijk MP, Lubinski J, Jakubowska A, Gronwald J, Huzarski T, Byrski T, Górski B, Cybulski C, Spurdle AB, Holland H, kConFab, Goldgar DE, John EM, Hopper JL, Southey M, Buys SS, Daly MB, Terry MB, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Preisler-Adams S, Arnold N, Niederacher D, Sutter C, Domchek SM, Nathanson KL, Rebbeck T, Blum JL, Piedmonte M, Rodriguez GC, Wakeley K, Boggess JF, Basil J, Blank SV, Friedman E, Kaufman B, Laitman Y, Milgrom R, Andrulis IL, Glendon G, Ozcelik H, Kirchhoff T, Vijai J, Gaudet MM, Altshuler D, Guiducci C, SWE-BRCA, Loman N, Harbst K, Rantala J, Ehrencrona H, Gerdes AM, Thomassen M, Sunde L, Peterlongo P, Manoukian S, Bonanni B, Viel A, Radice P, Caldes T, de la Hoya M, Singer CF, Fink-Retter A, Greene MH, Mai PL, Loud JT, Guidugli L, Lindor NM, Hansen TV, Nielsen FC, Blanco I, Lazaro C, Garber J, Ramus SJ, Gayther SA, Phelan C, Narod S, Szabo CI, MOD SQUAD, Benitez J, Osorio A, Nevanlinna H, Heikkinen T, Caligo MA, Beattie MS, Hamann U, Godwin AK, Montagna M, Casella C, Neuhausen SL, Karlan BY, Tung N, Toland AE, Weitzel J, Olopade O, Simard J, Soucy P, Rubinstein WS, Arason A, Rennert G, Martin NG, Montgomery GW, Chang-Claude J, Flesch-Janys D, Brauch H, GENICA, Severi G, Baglietto L, Cox A, Cross SS, Miron P, Gerty SM, Tapper W, Yannoukakos D, Fountzilas G, Fasching PA, Beckmann MW, Dos Santos Silva I, Peto J, Lambrechts D, Paridaens R, Rüdiger T, Försti A, Winqvist R, Pylkäs K, Diasio RB, Lee AM, Eckel-Passow J, Vachon C, Blows F, Driver K, Dunning A, Pharoah PP, Offit K, Pankratz VS, Hakonarson H, Chenevix-Trench G, Easton DF, Couch FJ
Nat Genet. 2010
PubMed ID: 20852631
Novel BRCA1/2 mutations in Serbian breast and breast-ovarian cancer patients with hereditary predisposition.
Dobricić J, Branković-Magić M, Filipović S, Radulović S
Cancer Genet Cytogenet. 2010
PubMed ID: 20804917
An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K
Hum Genet. 2010
PubMed ID: 20677014
Identification of point mutations and large rearrangements in the BRCA1 gene in 667 Turkish unselected ovarian cancer patients.
Aktas D, Gultekin M, Kabacam S, Alikasifoglu M, Turan AT, Tulunay G, Kose MF, Ortac F, Yüce K, Tunçbilek E, Ayhan A
Gynecol Oncol. 2010
PubMed ID: 20638108
Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.
Liu Y, Shete S, Wang LE, El-Zein R, Etzel CJ, Liang FW, Armstrong G, Tsavachidis S, Gilbert MR, Aldape KD, Xing J, Wu X, Wei Q, Bondy ML
Carcinogenesis. 2010
PubMed ID: 20610542
Risk of breast cancer in male BRCA2 carriers.
Evans DG, Susnerwala I, Dawson J, Woodward E, Maher ER, Lalloo F
J Med Genet. 2010
PubMed ID: 20587410
High frequency and allele-specific differences of BRCA1 founder mutations in breast cancer and ovarian cancer patients from Belarus.
Bogdanova NV, Antonenkova NN, Rogov YI, Karstens JH, Hillemanns P, Dörk T
Clin Genet. 2010
PubMed ID: 20569256
"The bigger the network the bigger the bowl of cherries...": exploring the acceptability of, and preferences for, an ongoing support network for known BRCA 1 and BRCA 2 mutation carriers.
Hughes L, Phelps C
J Genet Couns. 2010
PubMed ID: 20411314
Copy number variations are not modifiers of phenotypic expression in a pair of identical twins carrying a BRCA1 mutation.
Lasa A, Ramón y Cajal T, Llort G, Suela J, Cigudosa JC, Cornet M, Alonso C, Barnadas A, Baiget M
Breast Cancer Res Treat. 2010
PubMed ID: 20369283
Spectrum of BRCA1/2 point mutations and genomic rearrangements in high-risk breast/ovarian cancer Chilean families.
Gonzalez-Hormazabal P, Gutierrez-Enriquez S, Gaete D, Reyes JM, Peralta O, Waugh E, Gomez F, Margarit S, Bravo T, Blanco R, Diez O, Jara L
Breast Cancer Res Treat. 2010
PubMed ID: 20859677
Expanding the criteria for BRCA mutation testing in breast cancer survivors.
Kwon JS, Gutierrez-Barrera AM, Young D, Sun CC, Daniels MS, Lu KH, Arun B
J Clin Oncol. 2010
PubMed ID: 20733129
Family history, BRCA mutations and breast cancer in Vietnamese women.
Ginsburg O, Dinh N, To T, Quang L, Linh N, Duong B, Royer R, Llacuachaqui M, Vichodez G, Li S, Love R, Narod S
Clin Genet. 2010
PubMed ID: 20950396
BRCA1-associated epigenetic regulation of p73 mediates an effector pathway for chemosensitivity in ovarian carcinoma.
Ibrahim N, He L, Leong CO, Xing D, Karlan BY, Swisher EM, Rueda BR, Orsulic S, Ellisen LW
Cancer Res. 2010
PubMed ID: 20807817
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.
Molyneux G, Geyer FC, Magnay FA, McCarthy A, Kendrick H, Natrajan R, Mackay A, Grigoriadis A, Tutt A, Ashworth A, Reis-Filho JS, Smalley MJ
Cell Stem Cell. 2010
PubMed ID: 20804975
Sporadic breast carcinomas with somatic BRCA1 gene deletions share genotype/phenotype features with familial breast carcinomas.
Rhiem K, Todt U, Wappenschmidt B, Klein A, Wardelmann E, Schmutzler RK
Anticancer Res. 2010
PubMed ID: 20944121
Association between mitogen-activated protein kinase kinase kinase 1 rs889312 polymorphism and breast cancer risk: evidence from 59,977 subjects.
Lu PH, Yang J, Li C, Wei MX, Shen W, Shi LP, Jiang ZY, Zhou N, Tao GQ
Breast Cancer Res Treat. 2010
PubMed ID: 20809358
Risk factors for non-invasive lesions of the fallopian tube in BRCA mutation carriers.
Vicus D, Shaw PA, Finch A, Rosen B, Murphy J, Armel S, Sun P, Narod SA
Gynecol Oncol. 2010
PubMed ID: 20722102
Expression of the stem cell marker ALDH1 in the normal breast of BRCA1 mutation carriers.
Heerma van Voss MR, van der Groep P, Bart J, van der Wall E, van Diest PJ
Breast Cancer Res Treat. 2010
PubMed ID: 20585849
Prevalence of BRCA1 and BRCA2 germ line mutations among women with carcinoma of the fallopian tube.
Vicus D, Finch A, Cass I, Rosen B, Murphy J, Fan I, Royer R, McLaughlin J, Karlan B, Narod SA
Gynecol Oncol. 2010
PubMed ID: 20570322
Identification of a Danish breast/ovarian cancer family double heterozygote for BRCA1 and BRCA2 mutations.
Steffensen AY, Jønson L, Ejlertsen B, Gerdes AM, Nielsen FC, Hansen TV
Fam Cancer. 2010
PubMed ID: 20455026
RASSF1A polymorphism in familial breast cancer.
Bergqvist J, Latif A, Roberts SA, Hadfield KD, Lalloo F, Howell A, Evans DG, Newman WG
Fam Cancer. 2010
PubMed ID: 20361264
Adjuvant systemic therapy for breast cancer in BRCA1/BRCA2 mutation carriers in a population-based study of risk of contralateral breast cancer.
Reding KW, Bernstein JL, Langholz BM, Bernstein L, Haile RW, Begg CB, Lynch CF, Concannon P, Borg A, Teraoka SN, Törngren T, Diep A, Xue S, Bertelsen L, Liang X, Reiner AS, Capanu M, Malone KE, WECARE Collaborative Study Group
Breast Cancer Res Treat. 2010
PubMed ID: 20135344
Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer.
Hu H, Zhang Y, Zou M, Yang S, Liang XQ
J Cancer Res Clin Oncol. 2010
PubMed ID: 20127252
Identification of the first case of germline duplication of BRCA1 exon 13 in an Italian family.
Cerutti R, Sahnane N, Carnevali I, Furlan D, Tibiletti MG, Chiaravalli AM, Capella C
Fam Cancer. 2010
PubMed ID: 20041308
UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer.
Jin W, Chen L, Chen Y, Xu SG, Di GH, Yin WJ, Wu J, Shao ZM
Breast Cancer Res Treat. 2010
PubMed ID: 19943104
The CYP17A1 -34T > C polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Kaufman B, Laitman Y, Ziv E, Hamann U, Torres D, Lahad EL, Beeri R, Renbaum P, Jakubowska A, Lubinski J, Huzarski T, Tołoczko-Grabarek A, Jaworska K, Durda K, Sprudle AB, Chenevix-Trench G, Simard J, Easton DF, Antonis A, Szabo C, Friedman E
Breast Cancer Res Treat. 2010
PubMed ID: 20798986
Body weight and risk of breast cancer in BRCA1/2 mutation carriers.
Manders P, Pijpe A, Hooning MJ, Kluijt I, Vasen HF, Hoogerbrugge N, van Asperen CJ, Meijers-Heijboer H, Ausems MG, van Os TA, Gomez-Garcia EB, Brohet RM, HEBON, van Leeuwen FE, Rookus MA
Breast Cancer Res Treat. 2010
PubMed ID: 20730487
Is mammographic breast density a breast cancer risk factor in women with BRCA mutations?
Passaperuma K, Warner E, Hill KA, Gunasekara A, Yaffe MJ
J Clin Oncol. 2010
PubMed ID: 20625126
Induction of breast cancer in wild type p53 cells by BRCA1-IRIS overexpression.
Elshamy WM
Hawaii Med J. 2010
PubMed ID: 20845286
HERC2 is an E3 ligase that targets BRCA1 for degradation.
Wu W, Sato K, Koike A, Nishikawa H, Koizumi H, Venkitaraman AR, Ohta T
Cancer Res. 2010
PubMed ID: 20631078
DNA damage-induced cytotoxicity is dissociated from BRCA1's DNA repair function but is dependent on its cytosolic accumulation.
Wang H, Yang ES, Jiang J, Nowsheen S, Xia F
Cancer Res. 2010
PubMed ID: 20631074
6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance.
Issaeva N, Thomas HD, Djurenovic T, Jaspers JE, Stoimenov I, Kyle S, Pedley N, Gottipati P, Zur R, Sleeth K, Chatzakos V, Mulligan EA, Lundin C, Gubanova E, Kersbergen A, Harris AL, Sharma RA, Rottenberg S, Curtin NJ, Helleday T
Cancer Res. 2010
PubMed ID: 20631063
BRCA1 16 years later: nuclear import and export processes.
Thompson ME
FEBS J. 2010
PubMed ID: 20608972
BRCA1 16 years later: DNA damage-induced BRCA1 shuttling.
Yang ES, Xia F
FEBS J. 2010
PubMed ID: 20608971
BRCA1 16 years later: risk-associated BRCA1 mutations and their functional implications.
Linger RJ, Kruk PA
FEBS J. 2010
PubMed ID: 20608970
Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer.
Hennessy BT, Timms KM, Carey MS, Gutin A, Meyer LA, Flake DD, Abkevich V, Potter J, Pruss D, Glenn P, Li Y, Li J, Gonzalez-Angulo AM, McCune KS, Markman M, Broaddus RR, Lanchbury JS, Lu KH, Mills GB
J Clin Oncol. 2010
PubMed ID: 20606085
Oral contraceptive use and breast or ovarian cancer risk in BRCA1/2 carriers: a meta-analysis.
Iodice S, Barile M, Rotmensz N, Feroce I, Bonanni B, Radice P, Bernard L, Maisonneuve P, Gandini S
Eur J Cancer. 2010
PubMed ID: 20537530
Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice.
Rantakari P, Nikkilä J, Jokela H, Ola R, Pylkäs K, Lagerbohm H, Sainio K, Poutanen M, Winqvist R
Hum Mol Genet. 2010
PubMed ID: 20484223
BRCA1, BRCA2 and CHEK2 c.1100 delC mutations in patients with double primaries of the breasts and/or ovaries.
Evans DG, Ahmed M, Bayliss S, Howard E, Lalloo F, Wallace A
J Med Genet. 2010
PubMed ID: 20472656
Risk factors for carcinoma of the fallopian tube in women with and without a germline BRCA mutation.
Vicus D, Finch A, Rosen B, Fan I, Bradley L, Cass I, Sun P, Karlan B, McLaughlin J, Narod SA, Hereditary Ovarian Cancer Clinical Study Group
Gynecol Oncol. 2010
PubMed ID: 20452659
Identification of novel large genomic rearrangements at the BRCA1 locus in Malaysian women with breast cancer.
Sharifah NA, Nurismah MI, Lee HC, Aisyah AN, Clarence-Ko CH, Naqiyah I, Rohaizak M, Fuad I, A Jamal AR, Zarina AL, Nor Aina E, Normayah K, Nor Hisham A
Cancer Epidemiol. 2010
PubMed ID: 20451485
Prevalence of the variant allele rs61764370 T>G in the 3'UTR of KRAS among Dutch BRCA1, BRCA2 and non-BRCA1/BRCA2 breast cancer families.
Hollestelle A, Pelletier C, Hooning M, Crepin E, Schutte M, Look M, Collee JM, Nieuwlaat A, Dorssers LC, Seynaeve C, Aulchenko YS, Martens JW, van den Ouweland AM, Weidhaas JB
Breast Cancer Res Treat. 2010
PubMed ID: 20676756
Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci.
Tonic I, Yu WN, Park Y, Chen CC, Hay N
J Biol Chem. 2010
PubMed ID: 20495005
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial.
Audeh MW, Carmichael J, Penson RT, Friedlander M, Powell B, Bell-McGuinn KM, Scott C, Weitzel JN, Oaknin A, Loman N, Lu K, Schmutzler RK, Matulonis U, Wickens M, Tutt A
Lancet. 2010
PubMed ID: 20609468
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial.
Tutt A, Robson M, Garber JE, Domchek SM, Audeh MW, Weitzel JN, Friedlander M, Arun B, Loman N, Schmutzler RK, Wardley A, Mitchell G, Earl H, Wickens M, Carmichael J
Lancet. 2010
PubMed ID: 20609467
The CASP8 rs3834129 polymorphism and breast cancer risk in BRCA1 mutation carriers.
Catucci I, Verderio P, Pizzamiglio S, Manoukian S, Peissel B, Zaffaroni D, Roversi G, Ripamonti CB, Pasini B, Barile M, Viel A, Giannini G, Papi L, Varesco L, Martayan A, Riboni M, Volorio S, Radice P, Peterlongo P
Breast Cancer Res Treat. 2010
PubMed ID: 20652397
A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.
Ho-Pun-Cheung A, Assenat E, Bascoul-Mollevi C, Bibeau F, Boissière-Michot F, Thezenas S, Cellier D, Azria D, Rouanet P, Senesse P, Ychou M, Lopez-Crapez E
Pharmacogenomics J. 2010
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Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity.
Whitehouse CA, Waters S, Marchbank K, Horner A, McGowan NW, Jovanovic JV, Xavier GM, Kashima TG, Cobourne MT, Richards GO, Sharpe PT, Skerry TM, Grigoriadis AE, Solomon E
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20616007
Clinical significance of promoter hypermethylation of DNA repair genes in tumor and serum DNA in invasive ductal breast carcinoma patients.
Sharma G, Mirza S, Parshad R, Srivastava A, Gupta SD, Pandya P, Ralhan R
Life Sci. 2010
PubMed ID: 20470789
Risk factors associated with the occurrence of breast cancer after bilateral salpingo-oophorectomy in high-risk women.
Ramon Y Cajal T, Torres A, Alonso C, Fisas D, Ojeda B, Boguña I, Prat J, Baiget M, Barnadas A
Cancer Epidemiol. 2010
PubMed ID: 20638925
Variation within DNA repair pathway genes and risk of multiple sclerosis.
Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF, International Multiple Sclerosis Genetics Consortium
Am J Epidemiol. 2010
PubMed ID: 20522537
Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Wang X, Pankratz VS, Fredericksen Z, Tarrell R, Karaus M, McGuffog L, Pharaoh PD, Ponder BA, Dunning AM, Peock S, Cook M, Oliver C, Frost D, EMBRACE, Sinilnikova OM, Stoppa-Lyonnet D, Mazoyer S, Houdayer C, GEMO, Hogervorst FB, Hooning MJ, Ligtenberg MJ, HEBON, Spurdle A, Chenevix-Trench G, kConFab, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Domchek SM, Nathanson KL, Rebbeck TR, Singer CF, Gschwantler-Kaulich D, Dressler C, Fink A, Szabo CI, Zikan M, Foretova L, Claes K, Thomas G, Hoover RN, Hunter DJ, Chanock SJ, Easton DF, Antoniou AC, Couch FJ
Hum Mol Genet. 2010
PubMed ID: 20418484
Ionizing radiation or mitomycin-induced micronuclei in lymphocytes of BRCA1 or BRCA2 mutation carriers.
Gutiérrez-Enríquez S, Ramón Y Cajal T, Alonso C, Corral A, Carrasco P, Cornet M, Sanz J, Ribas M, Baiget M, Diez O
Breast Cancer Res Treat. 2010
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[No association between MTHFR 677C>T polymorphism and ovarian cancer risk in BRCA1 mutation carriers in Wielkopolska region].
Magnowski P, Seremak-Mrozikiewicz A, Nowak-Markwitz E, Kurzawińska G, Drews K, Spaczyński M
Ginekol Pol. 2010
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Impact of RING and BRCT domain mutations on BRCA1 protein stability, localization and recruitment to DNA damage.
Nelson AC, Holt JT
Radiat Res. 2010
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Soy phytoestrogens modify DNA methylation of GSTP1, RASSF1A, EPH2 and BRCA1 promoter in prostate cancer cells.
Vardi A, Bosviel R, Rabiau N, Adjakly M, Satih S, Dechelotte P, Boiteux JP, Fontana L, Bignon YJ, Guy L, Bernard-Gallon DJ
In Vivo. 2010
PubMed ID: 20668305
BRCA1 regulation of base excision repair pathway.
Saha T, Smulson M, Rosen EM
Cell Cycle. 2010
PubMed ID: 20581465
Interaction between BRCA1/BRCA2 and ATM/ATR associate with breast cancer susceptibility in a Chinese Han population.
Wang K, Ye Y, Xu Z, Zhang X, Hou Z, Cui Y, Song Y
Cancer Genet Cytogenet. 2010
PubMed ID: 20513533
Aberrant methylation of breast and ovarian cancer susceptibility gene 1 in chemosensitive human ovarian cancer cells does not involve the phosphatidylinositol 3'-kinase-Akt pathway.
Wang YQ, Zhang JR, Li SD, He YY, Yang YX, Liu XL, Wan XP
Cancer Sci. 2010
PubMed ID: 20487263
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
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Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
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Effect of BRCA1/2 mutation on short-term and long-term breast cancer survival: a systematic review and meta-analysis.
Lee EH, Park SK, Park B, Kim SW, Lee MH, Ahn SH, Son BH, Yoo KY, Kang D, KOHBRA Research Group, Korean Breast Cancer Society
Breast Cancer Res Treat. 2010
PubMed ID: 20376556
Toward classification of BRCA1 missense variants using a biophysical approach.
Rowling PJ, Cook R, Itzhaki LS
J Biol Chem. 2010
PubMed ID: 20378548
Transcriptional regulation of the base excision repair pathway by BRCA1.
Saha T, Rih JK, Roy R, Ballal R, Rosen EM
J Biol Chem. 2010
PubMed ID: 20185827
Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice.
Kumar R, Bourbon HM, de Massy B
Genes Dev. 2010
PubMed ID: 20551173
Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays.
Lee MS, Green R, Marsillac SM, Coquelle N, Williams RS, Yeung T, Foo D, Hau DD, Hui B, Monteiro AN, Glover JN
Cancer Res. 2010
PubMed ID: 20516115
Basal-like breast cancer displays distinct patterns of promoter methylation.
Lee JS, Fackler MJ, Lee JH, Choi C, Park MH, Yoon JH, Zhang Z, Sukumar S
Cancer Biol Ther. 2010
PubMed ID: 20505321
Can a phenotype for recessive inheritance in breast cancer be defined?
Ellberg C, Jönsson G, Olsson H
Fam Cancer. 2010
PubMed ID: 20549370
Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers.
Dennis J, Ghadirian P, Little J, Lubinski J, Gronwald J, Kim-Sing C, Foulkes W, Moller P, Lynch HT, Neuhausen SL, Domchek S, Armel S, Isaacs C, Tung N, Sweet K, Ainsworth P, Sun P, Krewski D, Narod S, the Hereditary Breast Cancer Clinical Study Group
Breast. 2010
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Risk factors for non-invasive lesions of the fallopian tube in BRCA mutation carriers.
Vicus D, Shaw PA, Finch A, Rosen B, Murphy J, Armel S, Sun P, Narod SA
Gynecol Oncol. 2010
PubMed ID: 20965088
Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: implications for prediction of pathogenicity.
Walker LC, Whiley PJ, Couch FJ, Farrugia DJ, Healey S, Eccles DM, Lin F, Butler SA, Goff SA, Thompson BA, Lakhani SR, Da Silva LM, kConFab Investigators, Tavtigian SV, Goldgar DE, Brown MA, Spurdle AB
Hum Mutat. 2010
PubMed ID: 20513136
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.
Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H, Hiddingh S, Thanasoula M, Kulkarni A, Yang Q, Haffty BG, Tommiska J, Blomqvist C, Drapkin R, Adams DJ, Nevanlinna H, Bartek J, Tarsounas M, Ganesan S, Jonkers J
Nat Struct Mol Biol. 2010
PubMed ID: 20453858
Local therapy in BRCA1 and BRCA2 mutation carriers with operable breast cancer: comparison of breast conservation and mastectomy.
Pierce LJ, Phillips KA, Griffith KA, Buys S, Gaffney DK, Moran MS, Haffty BG, Ben-David M, Kaufman B, Garber JE, Merajver SD, Balmaña J, Meirovitz A, Domchek SM
Breast Cancer Res Treat. 2010
PubMed ID: 20411323
Osteopontin can act as an effector for a germline mutation of BRCA1 in malignant transformation of breast cancer-related cells.
El-Tanani MK, Yuen HF, Shi Z, Platt-Higgins A, Buckley NE, Mullan PB, Harkin DP, Johnston PG, Rudland PS
Cancer Sci. 2010
PubMed ID: 20384635
The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function.
Wu-Baer F, Ludwig T, Baer R
Mol Cell Biol. 2010
PubMed ID: 20351172
[BRCA1 selectively regulates the expression of progesterone receptor A in sporadic invasive ductal breast carcinoma].
Wang X, Zhao T, Zhao JJ, Xiong JB
Zhonghua Yi Xue Za Zhi. 2010
PubMed ID: 20646629
Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.
Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J
Breast Cancer Res Treat. 2010
PubMed ID: 20496165
Increased incidence of visceral metastases in scottish patients with BRCA1/2-defective ovarian cancer: an extension of the ovarian BRCAness phenotype.
Gourley C, Michie CO, Roxburgh P, Yap TA, Harden S, Paul J, Ragupathy K, Todd R, Petty R, Reed N, Hayward RL, Mitchell P, Rye T, Schellens JH, Lubinski J, Carmichael J, Kaye SB, Mackean M, Ferguson M
J Clin Oncol. 2010
PubMed ID: 20406939
Population-based study of the risk of second primary contralateral breast cancer associated with carrying a mutation in BRCA1 or BRCA2.
Malone KE, Begg CB, Haile RW, Borg A, Concannon P, Tellhed L, Xue S, Teraoka S, Bernstein L, Capanu M, Reiner AS, Riedel ER, Thomas DC, Mellemkjaer L, Lynch CF, Boice JD, Anton-Culver H, Bernstein JL
J Clin Oncol. 2010
PubMed ID: 20368571
HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.
Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM
J Clin Invest. 2010
PubMed ID: 20389018
Concomitant loss of heterozygosity at the BRCA1 and FHIT genes as a prognostic factor in sporadic breast cancer.
Silva Soares EW, de Lima Santos SC, Bueno AG, Cavalli IJ, Cavalli LR, Fouto Matias JE, de Souza Fonseca Ribeiro EM
Cancer Genet Cytogenet. 2010
PubMed ID: 20417865
The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells.
Stolz A, Ertych N, Kienitz A, Vogel C, Schneider V, Fritz B, Jacob R, Dittmar G, Weichert W, Petersen I, Bastians H
Nat Cell Biol. 2010
PubMed ID: 20364141
Hereditary breast and ovarian cancer due to mutations in BRCA1 and BRCA2.
Petrucelli N, Daly MB, Feldman GL
Genet Med. 2010
PubMed ID: 20216074
Negative feedback loop of BRCA1-BARD1 ubiquitin ligase on estrogen receptor alpha stability and activity antagonized by cancer-associated isoform of BARD1.
Dizin E, Irminger-Finger I
Int J Biochem Cell Biol. 2010
PubMed ID: 20060929
Broad BRCA1 and BRCA2 mutational spectrum and high incidence of recurrent and novel mutations in the eastern Spain population.
Esteban Cardeñosa E, Bolufer Gilabert P, de Juan Jimenez I, Palanca Suela S, Barragán González E, Chirivella González I, Segura Huerta A, Guillén Ponce C, Martínez de Dueñas E
Breast Cancer Res Treat. 2010
PubMed ID: 20033483
Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.
Loizidou MA, Cariolou MA, Neuhausen SL, Newbold RF, Bashiardes E, Marcou Y, Michael T, Daniel M, Kakouri E, Papadopoulos P, Malas S, Hadjisavvas A, Kyriacou K
Breast Cancer Res Treat. 2010
PubMed ID: 19714462
Targeting the FANCJ-BRCA1 interaction promotes a switch from recombination to poleta-dependent bypass.
Xie J, Litman R, Wang S, Peng M, Guillemette S, Rooney T, Cantor SB
Oncogene. 2010
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The AIB1 gene polyglutamine repeat length polymorphism and the risk of breast cancer development.
Kleibl Z, Havranek O, Kormunda S, Novotny J, Foretova L, Machackova E, Soukupova J, Janatova M, Tavandzis S, Pohlreich P
J Cancer Res Clin Oncol. 2010
PubMed ID: 20422428
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.
Bunting SF, Callén E, Wong N, Chen HT, Polato F, Gunn A, Bothmer A, Feldhahn N, Fernandez-Capetillo O, Cao L, Xu X, Deng CX, Finkel T, Nussenzweig M, Stark JM, Nussenzweig A
Cell. 2010
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Immunohistochemical expression of BRCA1 and lethal prostate cancer.
Fiorentino M, Judson G, Penney K, Flavin R, Stark J, Fiore C, Fall K, Martin N, Ma J, Sinnott J, Giovannucci E, Stampfer M, Sesso HD, Kantoff PW, Finn S, Loda M, Mucci L
Cancer Res. 2010
PubMed ID: 20388772
Mouse models for breast cancer metastasis.
Kim IS, Baek SH
Biochem Biophys Res Commun. 2010
PubMed ID: 20230796
[BRCA1- and BRCA2 mutations: Clinical management of patients with hereditary breast and ovarian cancer].
Pristauz G, Geigl JB, Petru E
Wien Med Wochenschr. 2010
PubMed ID: 20473725
A BRCA1 promoter variant (rs11655505) and breast cancer risk.
Verderio P, Pizzamiglio S, Southey MC, Spurdle AB, Hopper JL, Chen X, Beesley J, Australian Ovarian Cancer Study Group KConFab, Schmutzler RK, Engel C, Burwinkel B, Bugert P, Ficarazzi F, Manoukian S, Barile M, Wappenschmidt B, Chenevix-Trench G, Radice P, Peterlongo P
J Med Genet. 2010
PubMed ID: 20413709
MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.
Hayakawa T, Zhang F, Hayakawa N, Ohtani Y, Shinmyozu K, Nakayama J, Andreassen PR
J Cell Sci. 2010
PubMed ID: 20332121
Germline BRCA mutations denote a clinicopathologic subset of prostate cancer.
Gallagher DJ, Gaudet MM, Pal P, Kirchhoff T, Balistreri L, Vora K, Bhatia J, Stadler Z, Fine SW, Reuter V, Zelefsky M, Morris MJ, Scher HI, Klein RJ, Norton L, Eastham JA, Scardino PT, Robson ME, Offit K
Clin Cancer Res. 2010
PubMed ID: 20215531
BRCA1 gene mutations may explain more than 80% of excess number of ovarian cancer cases after breast cancer - a population based study from the Western Sweden Health Care region.
Einbeigi Z, Enerbäck C, Wallgren A, Nordling M, Karlsson P
Acta Oncol. 2010
PubMed ID: 20151938
Risk-reducing mastectomy and salpingo-oophorectomy in unaffected BRCA mutation carriers: uptake and timing.
Skytte AB, Gerdes AM, Andersen MK, Sunde L, Brøndum-Nielsen K, Waldstrøm M, Kølvraa S, Crüger D
Clin Genet. 2010
PubMed ID: 20059483
Francisella novicida forms in vitro biofilms mediated by an orphan response regulator.
Durham-Colleran MW, Verhoeven AB, van Hoek ML
Microb Ecol. 2010
PubMed ID: 19763680
The c.5242C>A BRCA1 missense variant induces exon skipping by increasing splicing repressors binding.
Millevoi S, Bernat S, Telly D, Fouque F, Gladieff L, Favre G, Vagner S, Toulas C
Breast Cancer Res Treat. 2010
PubMed ID: 19404736
The contribution of founder mutations in BRCA1 to breast cancer in Belarus.
Uglanitsa N, Oszurek O, Uglanitsa K, Savonievich E, Lubiński J, Cybulski C, Debniak T, Narod SA, Gronwald J
Clin Genet. 2010
PubMed ID: 20507347
Long-term outcomes of breast cancer in women aged 30 years or younger, based on family history, pathology and BRCA1/BRCA2/TP53 status.
Evans DG, Moran A, Hartley R, Dawson J, Bulman B, Knox F, Howell A, Lalloo F
Br J Cancer. 2010
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Cloning and characterization of a new BRCA1 variant: A role for BRCT domains in apoptosis.
Gu M, Li H, Shen C, Wu L, Liu W, Miao L, Zheng C
Cancer Lett. 2010
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Structure of the DNA-bound BRCA1 C-terminal region from human replication factor C p140 and model of the protein-DNA complex.
Kobayashi M, Ab E, Bonvin AM, Siegal G
J Biol Chem. 2010
PubMed ID: 20081198
Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis.
Moorman PG, Iversen ES, Marcom PK, Marks JR, Wang F, Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab), Lee E, Ursin G, Rebbeck TR, Domchek SM, Arun B, Susswein L, Isaacs C, Garber JE, Visvanathan K, Griffin CA, Sutphen R, Brzosowicz J, Gruber S, Finkelstein DM, Schildkraut JM
Breast Cancer Res Treat. 2010
PubMed ID: 20309627
Single-nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent.
Yarden RI, Friedman E, Metsuyanim S, Olender T, Ben-Asher E, Papa MZ
Mol Carcinog. 2010
PubMed ID: 20306497
Identification of DBC1 as a transcriptional repressor for BRCA1.
Hiraike H, Wada-Hiraike O, Nakagawa S, Koyama S, Miyamoto Y, Sone K, Tanikawa M, Tsuruga T, Nagasaka K, Matsumoto Y, Oda K, Shoji K, Fukuhara H, Saji S, Nakagawa K, Kato S, Yano T, Taketani Y
Br J Cancer. 2010
PubMed ID: 20160719
A high proportion of DNA variants of BRCA1 and BRCA2 is associated with aberrant splicing in breast/ovarian cancer patients.
Sanz DJ, Acedo A, Infante M, Durán M, Pérez-Cabornero L, Esteban-Cardeñosa E, Lastra E, Pagani F, Miner C, Velasco EA
Clin Cancer Res. 2010
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BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription.
Harte MT, O'Brien GJ, Ryan NM, Gorski JJ, Savage KI, Crawford NT, Mullan PB, Harkin DP
Cancer Res. 2010
PubMed ID: 20215511
Increased chromosomal radiosensitivity in women carrying BRCA1/BRCA2 mutations assessed with the G2 assay.
Ernestos B, Nikolaos P, Koulis G, Eleni R, Konstantinos B, Alexandra G, Michael K
Int J Radiat Oncol Biol Phys. 2010
PubMed ID: 20206018
BRCA1 and XRCC1 polymorphisms associated with survival in advanced gastric cancer treated with taxane and cisplatin.
Shim HJ, Yun JY, Hwang JE, Bae WK, Cho SH, Lee JH, Kim HN, Shin MH, Kweon SS, Lee JH, Kim HJ, Chung IJ
Cancer Sci. 2010
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Absence of genomic BRCA1 and BRCA2 rearrangements in Ashkenazi breast and ovarian cancer families.
Stadler ZK, Saloustros E, Hansen NA, Schluger AE, Kauff ND, Offit K, Robson ME
Breast Cancer Res Treat. 2010
PubMed ID: 20221693
RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.
Fu X, Yucer N, Liu S, Li M, Yi P, Mu JJ, Yang T, Chu J, Jung SY, O'Malley BW, Gu W, Qin J, Wang Y
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20173098
Sleep disturbances in asymptomatic BRCA1/2 mutation carriers: women at high risk for breast-ovarian cancer.
Shochat T, Dagan E
J Sleep Res. 2010
PubMed ID: 20337906
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
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Penetrance of breast cancer, ovarian cancer and contralateral breast cancer in BRCA1 and BRCA2 families: high cancer incidence at older age.
van der Kolk DM, de Bock GH, Leegte BK, Schaapveld M, Mourits MJ, de Vries J, van der Hout AH, Oosterwijk JC
Breast Cancer Res Treat. 2010
PubMed ID: 20204502
Wild-type BRCA1, but not mutated BRCA1, regulates the expression of the nuclear form of beta-catenin.
Li H, Sekine M, Tung N, Avraham HK
Mol Cancer Res. 2010
PubMed ID: 20215423
Prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers: very low risk for subsequent breast cancer.
Kaas R, Verhoef S, Wesseling J, Rookus MA, Oldenburg HS, Peeters MJ, Rutgers EJ
Ann Surg. 2010
PubMed ID: 20134318
Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study.
Borg A, Haile RW, Malone KE, Capanu M, Diep A, Törngren T, Teraoka S, Begg CB, Thomas DC, Concannon P, Mellemkjaer L, Bernstein L, Tellhed L, Xue S, Olson ER, Liang X, Dolle J, Børresen-Dale AL, Bernstein JL
Hum Mutat. 2010
PubMed ID: 20104584
Cancer predisposing missense and protein truncating BARD1 mutations in non-BRCA1 or BRCA2 breast cancer families.
De Brakeleer S, De Grève J, Loris R, Janin N, Lissens W, Sermijn E, Teugels E
Hum Mutat. 2010
PubMed ID: 20077502
BRCA1 protein and nucleolin colocalize in breast carcinoma tissue and cancer cell lines.
Tulchin N, Chambon M, Juan G, Dikman S, Strauchen J, Ornstein L, Billack B, Woods NT, Monteiro AN
Am J Pathol. 2010
PubMed ID: 20075200
Prevalence of BRCA2 and CDKN2a mutations in German familial pancreatic cancer families.
Slater EP, Langer P, Fendrich V, Habbe N, Chaloupka B, Matthäi E, Sina M, Hahn SA, Bartsch DK
Fam Cancer. 2010
PubMed ID: 20195775
The contribution of founder mutations in BRCA1 to breast and ovarian cancer in Lithuania.
Elsakov P, Kurtinaitis J, Petraitis S, Ostapenko V, Razumas M, Razumas T, Meskauskas R, Petrulis K, Luksite A, Lubiński J, Górski B, Narod SA, Gronwald J
Clin Genet. 2010
PubMed ID: 20345474
Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer.
Bozhanov SS, Angelova SG, Krasteva ME, Markov TL, Christova SL, Gavrilov IG, Georgieva EI
J Cancer Res Clin Oncol. 2010
PubMed ID: 20177704
Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan.
Zander SA, Kersbergen A, van der Burg E, de Water N, van Tellingen O, Gunnarsdottir S, Jaspers JE, Pajic M, Nygren AO, Jonkers J, Borst P, Rottenberg S
Cancer Res. 2010
PubMed ID: 20145144
Derepression of HMGA2 via removal of ZBRK1/BRCA1/CtIP complex enhances mammary tumorigenesis.
Ahmed KM, Tsai CY, Lee WH
J Biol Chem. 2010
PubMed ID: 20007691
Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features.
Tung N, Wang Y, Collins LC, Kaplan J, Li H, Gelman R, Comander AH, Gallagher B, Fetten K, Krag K, Stoeckert KA, Legare RD, Sgroi D, Ryan PD, Garber JE, Schnitt SJ
Breast Cancer Res. 2010
PubMed ID: 20149218
Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1.
Campbell SJ, Edwards RA, Glover JN
Structure. 2010
PubMed ID: 20159462
UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination.
An JY, Kim EA, Jiang Y, Zakrzewska A, Kim DE, Lee MJ, Mook-Jung I, Zhang Y, Kwon YT
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20080676
The role of BRCA1 in DNA damage response.
Wu J, Lu LY, Yu X
Protein Cell. 2010
PubMed ID: 21203981
Cancer prevalence in 129 breast-ovarian cancer families tested for BRCA1 and BRCA2 mutations.
Schlebusch CM, Dreyer G, Sluiter MD, Yawitch TM, van den Berg HJ, van Rensburg EJ
S Afr Med J. 2010
PubMed ID: 20459916
BRCA1 represses amphiregulin gene expression.
Lamber EP, Horwitz AA, Parvin JD
Cancer Res. 2010
PubMed ID: 20103632
Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination.
Ransburgh DJ, Chiba N, Ishioka C, Toland AE, Parvin JD
Cancer Res. 2010
PubMed ID: 20103620
Elevated expression of Ki-67 identifies aggressive prostate cancers but does not distinguish BRCA1 or BRCA2 mutation carriers.
Mitra AV, Jameson C, Barbachano Y, Sodha N, Kote-Jarai Z, Javed A, Bancroft E, Fletcher A, Cooper C, Peock S, IMPACT and EMBRACE Collaborators, Easton D, Eeles R, Foster CS
Oncol Rep. 2010
PubMed ID: 20043088
Is the breast-conserving treatment with radiotherapy appropriate in BRCA1/2 mutation carriers? Long-term results and review of the literature.
Kirova YM, Savignoni A, Sigal-Zafrani B, de La Rochefordiere A, Salmon RJ, This P, Asselain B, Stoppa-Lyonnet D, Fourquet A
Breast Cancer Res Treat. 2010
PubMed ID: 20033769
Bayes analysis provides evidence of pathogenicity for the BRCA1 c.135-1G>T (IVS3-1) and BRCA2 c.7977-1G>C (IVS17-1) variants displaying in vitro splicing results of equivocal clinical significance.
Spurdle AB, Lakhani SR, Da Silva LM, Balleine RL, kConFab Investigators, Goldgar DE
Hum Mutat. 2010
PubMed ID: 20020529
BRCA1 185delAG mutant protein, BRAt, up-regulates maspin in ovarian epithelial cells.
O'Donnell JD, Linger RJ, Kruk PA
Gynecol Oncol. 2010
PubMed ID: 19906413
Preventing future cancers by testing women with ovarian cancer for BRCA mutations.
Kwon JS, Daniels MS, Sun CC, Lu KH
J Clin Oncol. 2010
PubMed ID: 19841329
Differential modulation of BRCA1 and BARD1 nuclear localisation and foci assembly by DNA damage.
Brodie KM, Henderson BR
Cell Signal. 2010
PubMed ID: 19796682
Characterization of BRCA1 ring finger variants of uncertain significance.
Sweet K, Senter L, Pilarski R, Wei L, Toland AE
Breast Cancer Res Treat. 2010
PubMed ID: 19543972
Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy.
Byrski T, Gronwald J, Huzarski T, Grzybowska E, Budryk M, Stawicka M, Mierzwa T, Szwiec M, Wisniowski R, Siolek M, Dent R, Lubinski J, Narod S
J Clin Oncol. 2010
PubMed ID: 20008645
Transcriptional autoregulation by BRCA1.
De Siervi A, De Luca P, Byun JS, Di LJ, Fufa T, Haggerty CM, Vazquez E, Moiola C, Longo DL, Gardner K
Cancer Res. 2010
PubMed ID: 20068145
Survival analysis of cancer risk reduction strategies for BRCA1/2 mutation carriers.
Kurian AW, Sigal BM, Plevritis SK
J Clin Oncol. 2010
PubMed ID: 19996031
Association of BRCA1 mutations with occult primary ovarian insufficiency: a possible explanation for the link between infertility and breast/ovarian cancer risks.
Oktay K, Kim JY, Barad D, Babayev SN
J Clin Oncol. 2010
PubMed ID: 19996028
Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin.
Wolf I, Laitman Y, Rubinek T, Abramovitz L, Novikov I, Beeri R, Kuro-O M, Koeffler HP, Catane R, Freedman LS, Levy-Lahad E, Karlan BY, Friedman E, Kaufman B
Oncogene. 2010
PubMed ID: 19802015
Turnover of BRCA1 involves in radiation-induced apoptosis.
Liu W, Zong W, Wu G, Fujita T, Li W, Wu J, Wan Y
PLoS One. 2010
PubMed ID: 21217819
Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells.
Valeri A, Alonso-Ferrero ME, Río P, Pujol MR, Casado JA, Pérez L, Jacome A, Agirre X, Calasanz MJ, Hanenberg H, Surrallés J, Prosper F, Albella B, Bueren JA
PLoS One. 2010
PubMed ID: 21203397
BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations.
Holstege H, Horlings HM, Velds A, Langerød A, Børresen-Dale AL, van de Vijver MJ, Nederlof PM, Jonkers J
BMC Cancer. 2010
PubMed ID: 21118481
PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells.
Hammond-Martel I, Pak H, Yu H, Rouget R, Horwitz AA, Parvin JD, Drobetsky EA, Affar el B
PLoS One. 2010
PubMed ID: 21103343
Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers.
Tung N, Miron A, Schnitt SJ, Gautam S, Fetten K, Kaplan J, Yassin Y, Buraimoh A, Kim JY, Szász AM, Tian R, Wang ZC, Collins LC, Brock J, Krag K, Legare RD, Sgroi D, Ryan PD, Silver DP, Garber JE, Richardson AL
Breast Cancer Res. 2010
PubMed ID: 21080930
Gross genomic alterations and gene expression profiles of high- grade serous carcinoma of the ovary with and without BRCA1 inactivation.
Pradhan M, Risberg BA, Tropé CG, van de Rijn M, Gilks CB, Lee CH
BMC Cancer. 2010
PubMed ID: 20843305
Comparing the frequency of common genetic variants and haplotypes between carriers and non-carriers of BRCA1 and BRCA2 deleterious mutations in Australian women diagnosed with breast cancer before 40 years of age.
Turkovic L, Gurrin LC, Bahlo M, Dite GS, Southey MC, Hopper JL
BMC Cancer. 2010
PubMed ID: 20807450
BRCA1: linking HOX to breast cancer suppression.
Jin K, Sukumar S
Breast Cancer Res. 2010
PubMed ID: 20727230
Developing functional assays for BRCA1 unclassified variants.
Webb M
Methods Mol Biol. 2010
PubMed ID: 20721750
Development of a scoring system to screen for BRCA1/2 mutations.
Evans GR, Lalloo F
Methods Mol Biol. 2010
PubMed ID: 20721747
Enhanced mismatch mutation analysis: simultaneous detection of point mutations and large scale rearrangements by capillary electrophoresis, application to BRCA1 and BRCA2.
Houdayer C, Moncoutier V, Champ J, Weber J, Viovy JL, Stoppa-Lyonnet D
Methods Mol Biol. 2010
PubMed ID: 20721742
Prioritizing candidate genetic modifiers of BRCA1 and BRCA2 using a combinatorial analysis of global expression and polymorphism association studies of breast cancer.
Walker LC, Spurdle AB
Methods Mol Biol. 2010
PubMed ID: 20721735
BRCA1 and BRCA2 germline mutations screening in Algerian breast/ovarian cancer families.
Cherbal F, Bakour R, Adane S, Boualga K, Benais-Pont G, Maillet P
Dis Markers. 2010
PubMed ID: 20683152
Methylation of the tumor suppressor protein, BRCA1, influences its transcriptional cofactor function.
Guendel I, Carpio L, Pedati C, Schwartz A, Teal C, Kashanchi F, Kehn-Hall K
PLoS One. 2010
PubMed ID: 20614009
Presymptomatic breast cancer in Egypt: role of BRCA1 and BRCA2 tumor suppressor genes mutations detection.
Ibrahim SS, Hafez EE, Hashishe MM
J Exp Clin Cancer Res. 2010
PubMed ID: 20579331
Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium.
Zhang L, Wang D, Jiang W, Edwards D, Qiu W, Barroilhet LM, Rho JH, Jin L, Seethappan V, Vitonis A, Wang J, Mok SC, Crum C, Cramer DW, Ye B
Reprod Biol Endocrinol. 2010
PubMed ID: 20576130
Incorporating tumour pathology information into breast cancer risk prediction algorithms.
Mavaddat N, Rebbeck TR, Lakhani SR, Easton DF, Antoniou AC
Breast Cancer Res. 2010
PubMed ID: 20482762
Excretion of estrogens, catecholestrogens and phytoestrogens in carriers of BRCA1 gene mutations: effects of metformin.
Berstein LM, Koskela A, Boyarkina MP, Adlercreutz H
Neoplasma. 2010
PubMed ID: 20429624
Lympho-vascular invasion in BRCA related breast cancer compared to sporadic controls.
van Voss MR, van der Groep P, Bart J, van der Wall E, van Diest PJ
BMC Cancer. 2010
PubMed ID: 20398395
BRCA1 mutations in women with familial or early-onset breast cancer and BRCA2 mutations in familial cancer in Estonia.
Tamboom K, Kaasik K, Arsavskaja J, Tekkel M, Lilleorg A, Padrik P, Metspalu A, Veidebaum T
Hered Cancer Clin Pract. 2010
PubMed ID: 20380699
Population-based study of BRCA1/2 mutations: family history based criteria identify minority of mutation carriers.
Mateju M, Stribrna J, Zikan M, Kleibl Z, Janatova M, Kormunda S, Novotny J, Soucek P, Petruzelka L, Pohlreich P
Neoplasma. 2010
PubMed ID: 20353281
DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response.
Dejeux E, Rønneberg JA, Solvang H, Bukholm I, Geisler S, Aas T, Gut IG, Børresen-Dale AL, Lønning PE, Kristensen VN, Tost J
Mol Cancer. 2010
PubMed ID: 20338046
Effect of genetic counseling and testing for BRCA1 and BRCA2 mutations in African American women: a randomized trial.
Halbert CH, Kessler L, Troxel AB, Stopfer JE, Domchek S
Public Health Genomics. 2010
PubMed ID: 20234119
Favourable ten-year overall survival in a Caucasian population with high probability of hereditary breast cancer.
Cortesi L, Masini C, Cirilli C, Medici V, Marchi I, Cavazzini G, Pasini G, Turchetti D, Federico M
BMC Cancer. 2010
PubMed ID: 20219108
The prognostic value of BRCA1 mRNA expression levels following neoadjuvant chemotherapy in breast cancer.
Margeli M, Cirauqui B, Castella E, Tapia G, Costa C, Gimenez-Capitan A, Barnadas A, Sanchez Ronco M, Benlloch S, Taron M, Rosell R
PLoS One. 2010
PubMed ID: 20209131
High penetrances of BRCA1 and BRCA2 mutations confirmed in a prospective series.
Møller P, Mæhle L, Engebretsen LF, Ludvigsen T, Jonsrud C, Apold J, Vabø A, Clark N
Hered Cancer Clin Pract. 2010
PubMed ID: 20180971
Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis.
Su F, Smilenov LB, Ludwig T, Zhou L, Zhu J, Zhou G, Hall EJ
Radiat Oncol. 2010
PubMed ID: 20175908
Use of DNA-damaging agents and RNA pooling to assess expression profiles associated with BRCA1 and BRCA2 mutation status in familial breast cancer patients.
Walker LC, Thompson BA, Waddell N, kConFab Investigators, Grimmond SM, Spurdle AB
PLoS Genet. 2010
PubMed ID: 20174566
Gene methylation in breast ductal fluid from BRCA1 and BRCA2 mutation carriers.
Antill YC, Mitchell G, Johnson SA, Devereux L, Milner A, Di Iulio J, Lindeman GJ, Kirk J, Phillips KA, Campbell IG
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20056647
Changes in the mouse estrus cycle in response to BRCA1 inactivation suggest a potential link between risk factors for familial and sporadic ovarian cancer.
Hong H, Yen HY, Brockmeyer A, Liu Y, Chodankar R, Pike MC, Stanczyk FZ, Maxson R, Dubeau L
Cancer Res. 2010
PubMed ID: 20028858
Alternative splicing and molecular characterization of splice site variants: BRCA1 c.591C>T as a case study.
Dosil V, Tosar A, Cañadas C, Pérez-Segura P, Díaz-Rubio E, Caldés T, de la Hoya M
Clin Chem. 2010
PubMed ID: 19892845
BRCA1 regulates acetylation and ubiquitination of estrogen receptor-alpha.
Ma Y, Fan S, Hu C, Meng Q, Fuqua SA, Pestell RG, Tomita YA, Rosen EM
Mol Endocrinol. 2010
PubMed ID: 19887647
Breast cancer risks in individuals testing negative for a known family mutation in BRCA1 or BRCA2.
Domchek SM, Gaudet MM, Stopfer JE, Fleischaut MH, Powers J, Kauff N, Offit K, Nathanson KL, Robson M
Breast Cancer Res Treat. 2010
PubMed ID: 19885732
Genomic alterations in histopathologically normal breast tissue from BRCA1 mutation carriers may be caused by BRCA1 haploinsufficiency.
Rennstam K, Ringberg A, Cunliffe HE, Olsson H, Landberg G, Hedenfalk I
Genes Chromosomes Cancer. 2010
PubMed ID: 19839046
Impact of androgen receptor cytosine-adenine-guanine polymorphisms on clinical outcome in BRCA mutation-associated epithelial ovarian cancers.
Li AJ, McAllister P, Karlan BY
Gynecol Oncol. 2010
PubMed ID: 19818997
A comparison of BRCA1 nuclear localization with 14 DNA damage response proteins and domains: identification of specific differences between BRCA1 and 53BP1 at DNA damage-induced foci.
Mok MT, Henderson BR
Cell Signal. 2010
PubMed ID: 19766185
Validation of the pedigree assessment tool (PAT) in families with BRCA1 and BRCA2 mutations.
Teller P, Hoskins KF, Zwaagstra A, Stanislaw C, Iyengar R, Green VL, Gabram SG
Ann Surg Oncol. 2010
PubMed ID: 19763692
Controversial BRCA1 allelotypes in commonly used breast cancer cell lines.
Karnan S, Mohseni M, Konishi Y, Tamaki A, Hosokawa Y, Park BH, Konishi H
Breast Cancer Res Treat. 2010
PubMed ID: 19585236
BRCA1-associated breast and ovarian cancer risks in Poland: no association with commonly studied polymorphisms.
Jakubowska A, Gronwald J, Menkiszak J, Górski B, Huzarski T, Byrski T, Tołoczko-Grabarek A, Gilbert M, Edler L, Zapatka M, Eils R, Lubiński J, Scott RJ, Hamann U
Breast Cancer Res Treat. 2010
PubMed ID: 19360465
Identification and functional analysis of novel BRCA1 transcripts, including mouse Brca1-Iris and human pseudo-BRCA1.
Pettigrew CA, French JD, Saunus JM, Edwards SL, Sauer AV, Smart CE, Lundström T, Wiesner C, Spurdle AB, Rothnagel JA, Brown MA
Breast Cancer Res Treat. 2010
PubMed ID: 19067158
Identification of a novel mutations BRCA1*c.80 + 3del4 and BRCA2*c.6589delA in Slovak HBOC families.
Konecny M, Vizvaryova M, Zavodna K, Behulova R, Gerykova Bujalkova M, Krivulcik T, Cisarik F, Kausitz J, Weismanova E
Breast Cancer Res Treat. 2010
PubMed ID: 19011960
BRCA1 localization to the telomere and its loss from the telomere in response to DNA damage.
Ballal RD, Saha T, Fan S, Haddad BR, Rosen EM
J Biol Chem. 2009
PubMed ID: 19797051
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.
Galanty Y, Belotserkovskaya R, Coates J, Polo S, Miller KM, Jackson SP
Nature. 2009
PubMed ID: 20016603
The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.
Morris JR, Boutell C, Keppler M, Densham R, Weekes D, Alamshah A, Butler L, Galanty Y, Pangon L, Kiuchi T, Ng T, Solomon E
Nature. 2009
PubMed ID: 20016594
Impaired skin and mammary gland development and increased gamma-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1.
Kim SS, Cao L, Baek HJ, Lim SC, Li C, Wang RH, Xu X, Cho KH, Deng CX
Cancer Res. 2009
PubMed ID: 19996295
Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA).
Osorio A, Milne RL, Pita G, Peterlongo P, Heikkinen T, Simard J, Chenevix-Trench G, Spurdle AB, Beesley J, Chen X, Healey S, KConFab, Neuhausen SL, Ding YC, Couch FJ, Wang X, Lindor N, Manoukian S, Barile M, Viel A, Tizzoni L, Szabo CI, Foretova L, Zikan M, Claes K, Greene MH, Mai P, Rennert G, Lejbkowicz F, Barnett-Griness O, Andrulis IL, Ozcelik H, Weerasooriya N, OCGN, Gerdes AM, Thomassen M, Cruger DG, Caligo MA, Friedman E, Kaufman B, Laitman Y, Cohen S, Kontorovich T, Gershoni-Baruch R, Dagan E, Jernström H, Askmalm MS, Arver B, Malmer B, SWE-BRCA, Domchek SM, Nathanson KL, Brunet J, Ramón Y Cajal T, Yannoukakos D, Hamann U, HEBON, Hogervorst FB, Verhoef S, Gómez García EB, Wijnen JT, van den Ouweland A, EMBRACE, Easton DF, Peock S, Cook M, Oliver CT, Frost D, Luccarini C, Evans DG, Lalloo F, Eeles R, Pichert G, Cook J, Hodgson S, Morrison PJ, Douglas F, Godwin AK, GEMO, Sinilnikova OM, Barjhoux L, Stoppa-Lyonnet D, Moncoutier V, Giraud S, Cassini C, Olivier-Faivre L, Révillion F, Peyrat JP, Muller D, Fricker JP, Lynch HT, John EM, Buys S, Daly M, Hopper JL, Terry MB, Miron A, Yassin Y, Goldgar D, Breast Cancer Family Registry, Singer CF, Gschwantler-Kaulich D, Pfeiler G, Spiess AC, Hansen TV, Johannsson OT, Kirchhoff T, Offit K, Kosarin K, Piedmonte M, Rodriguez GC, Wakeley K, Boggess JF, Basil J, Schwartz PE, Blank SV, Toland AE, Montagna M, Casella C, Imyanitov EN, Allavena A, Schmutzler RK, Versmold B, Engel C, Meindl A, Ditsch N, Arnold N, Niederacher D, Deissler H, Fiebig B, Varon-Mateeva R, Schaefer D, Froster UG, Caldes T, de la Hoya M, McGuffog L, Antoniou AC, Nevanlinna H, Radice P, Benítez J, CMBA
Br J Cancer. 2009
PubMed ID: 19920816
Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Graeser MK, Engel C, Rhiem K, Gadzicki D, Bick U, Kast K, Froster UG, Schlehe B, Bechtold A, Arnold N, Preisler-Adams S, Nestle-Kraemling C, Zaino M, Loeffler M, Kiechle M, Meindl A, Varga D, Schmutzler RK
J Clin Oncol. 2009
PubMed ID: 19858402
Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer.
Kwong A, Wong LP, Wong HN, Law FB, Ng EK, Tang YH, Chan WK, Suen DT, Choi C, Ho LS, Kwan KH, Poon M, Wong TT, Chan K, Chan SW, Ying MW, Chan WC, Ma ES, Ford JM, West DW
Hugo J. 2009
PubMed ID: 20535403
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras.
Navaraj A, Finnberg N, Dicker DT, Yang W, Matthew EM, El-Deiry WS
Cancer Biol Ther. 2009
PubMed ID: 20038817
Two founder BRCA2 mutations predispose to breast cancer in young women.
Infante M, Durán M, Lasa A, Acedo A, de la Hoya M, Esteban-Cardeñosa E, Sanz DJ, Pérez-Cabornero L, Lastra E, Miner C, Velasco EA
Breast Cancer Res Treat. 2009
PubMed ID: 19949853
Multistep level sections to detect occult fallopian tube carcinoma in risk-reducing salpingo-oophorectomies from women with BRCA mutations: implications for defining an optimal specimen dissection protocol.
Rabban JT, Krasik E, Chen LM, Powell CB, Crawford B, Zaloudek CJ
Am J Surg Pathol. 2009
PubMed ID: 19898224
Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation.
Ray A, Mir SN, Wani G, Zhao Q, Battu A, Zhu Q, Wang QE, Wani AA
Mol Cell Biol. 2009
PubMed ID: 19805520
Recurrent copy number alterations in BRCA1-mutated ovarian tumors alter biological pathways.
Leunen K, Gevaert O, Daemen A, Vanspauwen V, Michils G, De Moor B, Moerman P, Vergote I, Legius E
Hum Mutat. 2009
PubMed ID: 19802895
[BRCA1- and BRCA2- associated breast carcinomas]
Ahrens P, Kreipe HH
Pathologe. 2009
PubMed ID: 19795125
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q
Occup Environ Med. 2009
PubMed ID: 19773279
Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women.
Kontorovich T, Levy A, Korostishevsky M, Nir U, Friedman E
Int J Cancer. 2009
PubMed ID: 19950226
Heterogeneous prevalence of recurrent BRCA1 and BRCA2 mutations in Spain according to the geographical area: implications for genetic testing.
Diez O, Gutiérrez-Enríquez S, Balmaña J
Fam Cancer. 2009
PubMed ID: 19941167
Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Spurdle AB, Fahey P, Chen X, McGuffog L, kConFab, Easton D, Peock S, Cook M, EMBRACE, Simard J, INHERIT, Rebbeck TR, MAGIC, Antoniou AC, Chenevix-Trench G
Breast Cancer Res Treat. 2009
PubMed ID: 19921428
Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells.
Ueki T, Park JH, Nishidate T, Kijima K, Hirata K, Nakamura Y, Katagiri T
Cancer Res. 2009
PubMed ID: 19887602
Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers.
Antoniou AC, Sinilnikova OM, McGuffog L, Healey S, Nevanlinna H, Heikkinen T, Simard J, Spurdle AB, Beesley J, Chen X, The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Neuhausen SL, Ding YC, Couch FJ, Wang X, Fredericksen Z, Peterlongo P, Peissel B, Bonanni B, Viel A, Bernard L, Radice P, Szabo CI, Foretova L, Zikan M, Claes K, Greene MH, Mai PL, Rennert G, Lejbkowicz F, Andrulis IL, Ozcelik H, Glendon G, OCGN, Gerdes AM, Thomassen M, Sunde L, Caligo MA, Laitman Y, Kontorovich T, Cohen S, Kaufman B, Dagan E, Baruch RG, Friedman E, Harbst K, Barbany-Bustinza G, Rantala J, Ehrencrona H, Karlsson P, Domchek SM, Nathanson KL, Osorio A, Blanco I, Lasa A, Benítez J, Hamann U, Hogervorst FB, Rookus MA, Collee JM, Devilee P, Ligtenberg MJ, van der Luijt RB, Aalfs CM, Waisfisz Q, Wijnen J, van Roozendaal CE, HEBON, Peock S, Cook M, Frost D, Oliver C, Platte R, Evans DG, Lalloo F, Eeles R, Izatt L, Davidson R, Chu C, Eccles D, Cole T, Hodgson S, EMBRACE, Godwin AK, Stoppa-Lyonnet D, Buecher B, Léoné M, Bressac-de Paillerets B, Remenieras A, Caron O, Lenoir GM, Sevenet N, Longy M, Ferrer SF, Prieur F, GEMO, Goldgar D, Miron A, John EM, Buys SS, Daly MB, Hopper JL, Terry MB, Yassin Y, Breast Cancer Family Registry, Christian Singer, Gschwantler-Kaulich D, Staudigl C, Hansen TV, Barkardottir RB, Kirchhoff T, Pal P, Kosarin K, Offit K, Piedmonte M, Rodriguez GC, Wakeley K, Boggess JF, Basil J, Schwartz PE, Blank SV, Toland AE, Montagna M, Casella C, Imyanitov EN, Allavena A, Schmutzler RK, Versmold B, Engel C, Meindl A, Ditsch N, Arnold N, Niederacher D, Deißler H, Fiebig B, Suttner C, Schönbuchner I, Gadzicki D, Caldes T, de la Hoya M, Pooley KA, Easton DF, Chenevix-Trench G, on behalf of CIMBA.
Hum Mol Genet. 2009
PubMed ID: 19656774
[Detection of 5382insC mutation in human BRCA1 gene using fluorescent labeled oligonucleotides]
Mitrofanov DV, Chasovnikova OB, Kovalenko SP, Liakhovich VV
Mol Biol (Mosk). 2009
PubMed ID: 20088375
Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer.
Schjølberg AR, Clausen OP, Burum-Auensen E, De Angelis PM
Anticancer Res. 2009
PubMed ID: 20032382
Analysis of BRCA1 and BRCA2 mutations in southern Iranian Breast cancer patients.
Fattahi MJ, Mojtahedi Z, Karimaghaee N, Talei AR, Banani SJ, Ghaderi A
Arch Iran Med. 2009
PubMed ID: 19877752
The contribution of founder mutations to early-onset breast cancer in French-Canadian women.
Ghadirian P, Robidoux A, Zhang P, Royer R, Akbari M, Zhang S, Fafard E, Costa M, Martin G, Potvin C, Patocskai E, Larouche N, Younan R, Nassif E, Giroux S, Narod SA, Rousseau F, Foulkes WD
Clin Genet. 2009
PubMed ID: 19863560
A role for BRCA1 in uterine leiomyosarcoma.
Xing D, Scangas G, Nitta M, He L, Xu X, Ioffe YJ, Aspuria PJ, Hedvat CY, Anderson ML, Oliva E, Karlan BY, Mohapatra G, Orsulic S
Cancer Res. 2009
PubMed ID: 19843854
Selenium supplementation reduced oxidative DNA damage in adnexectomized BRCA1 mutations carriers.
Dziaman T, Huzarski T, Gackowski D, Rozalski R, Siomek A, Szpila A, Guz J, Lubinski J, Wasowicz W, Roszkowski K, Olinski R
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19843683
Germline mutations in MEN1 and BRCA1 genes in a woman with familial multiple endocrine neoplasia type 1 and inherited breast-ovarian cancer syndromes: a case report.
Papi L, Palli D, Masi L, Putignano AL, Congregati C, Zanna I, Marini F, Giusti F, Luzi E, Tonelli F, Genuardi M, Brandi ML, Falchetti A
Cancer Genet Cytogenet. 2009
PubMed ID: 19837273
Elevated level of 8-oxo-7,8-dihydro-2'-deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls.
Dziaman T, Huzarski T, Gackowski D, Rozalski R, Siomek A, Szpila A, Guz J, Lubinski J, Olinski R
Int J Cancer. 2009
PubMed ID: 19623658
Characterization of cancer-linked BRCA1-BRCT missense variants and their interaction with phosphoprotein targets.
Drikos I, Nounesis G, Vorgias CE
Proteins. 2009
PubMed ID: 19452558
The Leu33Pro polymorphism in the ITGB3 gene does not modify BRCA1/2-associated breast or ovarian cancer risks: results from a multicenter study among 15,542 BRCA1 and BRCA2 mutation carriers.
Jakubowska A, Rozkrut D, Antoniou A, Hamann U, Lubinski J
Breast Cancer Res Treat. 2009
PubMed ID: 19876733
Gene expression profiling integrated into network modelling reveals heterogeneity in the mechanisms of BRCA1 tumorigenesis.
Fernández-Ramires R, Solé X, De Cecco L, Llort G, Cazorla A, Bonifaci N, Garcia MJ, Caldés T, Blanco I, Gariboldi M, Pierotti MA, Pujana MA, Benítez J, Osorio A
Br J Cancer. 2009
PubMed ID: 19826428
The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Sinilnikova OM, Antoniou AC, Simard J, Healey S, Léoné M, Sinnett D, Spurdle AB, Beesley J, Chen X, kConFab, Greene MH, Loud JT, Lejbkowicz F, Rennert G, Dishon S, Andrulis IL, OCGN, Domchek SM, Nathanson KL, Manoukian S, Radice P, Konstantopoulou I, Blanco I, Laborde AL, Durán M, Osorio A, Benitez J, Hamann U, Hogervorst FB, van Os TA, Gille HJ, HEBON, Peock S, Cook M, Luccarini C, Evans DG, Lalloo F, Eeles R, Pichert G, Davidson R, Cole T, Cook J, Paterson J, Brewer C, EMBRACE, Hughes DJ, Coupier I, Giraud S, Coulet F, Colas C, Soubrier F, Rouleau E, Bièche I, Lidereau R, Demange L, Nogues C, Lynch HT, GEMO, Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Sutter C, Deissler H, Schaefer D, Froster UG, GC-HBOC, Aittomäki K, Nevanlinna H, McGuffog L, Easton DF, Chenevix-Trench G, Stoppa-Lyonnet D, Consortium of Investigators of Modifiers of BRCA1/2
Br J Cancer. 2009
PubMed ID: 19707196
BRCA1 tumours correlate with a HIF-1alpha phenotype and have a poor prognosis through modulation of hydroxylase enzyme profile expression.
Yan M, Rayoo M, Takano EA, Thorne H, Fox SB
Br J Cancer. 2009
PubMed ID: 19724277
A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.
Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD
Postgrad Med J. 2009
PubMed ID: 19789190
Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations.
Chang S, Biswas K, Martin BK, Stauffer S, Sharan SK
J Clin Invest. 2009
PubMed ID: 19770520
Disentangling the Babylonian speech confusion in genetic counseling: an analysis of the reliability and validity of the nomenclature for BRCA1/2 DNA-test results other than pathogenic.
Vos J, van Asperen CJ, Wijnen JT, Stiggelbout AM, Tibben A
Genet Med. 2009
PubMed ID: 19745749
Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination.
Christensen DE, Klevit RE
FEBS J. 2009
PubMed ID: 19712108
Clinical and pathologic differences between BRCA1-, BRCA2-, and non-BRCA-associated breast cancers in a multiracial developing country.
Yip CH, Taib NA, Choo WY, Rampal S, Thong MK, Teo SH
World J Surg. 2009
PubMed ID: 19649760
Advantages of the high resolution melting in the detection of BRCA1 or BRCA2 mutation carriers.
Jiménez Ide J, Esteban Cardeñosa E, Palanca Suela S, González EB, Bolufer Gilabert P, Group of Cancer Genetic Counselling Program of Valencia Community
Clin Biochem. 2009
PubMed ID: 19616529
A BRCA2 founder mutation and seven novel deleterious BRCA mutations in southern Chinese women with breast and ovarian cancer.
Kwong A, Wong LP, Wong HN, Law FB, Ng EK, Tang YH, Chan WK, Ho LS, Kwan KH, Poon M, Wong TT, Leung FC, Chan SW, Ying MW, Ma ES, Ford JM
Breast Cancer Res Treat. 2009
PubMed ID: 19353265
Absence of the BRCA1 del (exons 9-12) mutation in breast/ovarian cancer families outside of Mexican Hispanics.
Torres D, Rashid MU, Colombian Breast Cancer Study Group (COLBCS), Seidel-Renkert A, Weitzel JN, Briceno I, Hamann U
Breast Cancer Res Treat. 2009
PubMed ID: 19333752
Evaluation of a breast/ovarian cancer genetics referral screening tool in a mammography population.
Bellcross CA, Lemke AA, Pape LS, Tess AL, Meisner LT
Genet Med. 2009
PubMed ID: 19752737
Mutation scanning of exon 20 of the BRCA1 gene by high-resolution melting curve analysis.
Vorkas PA, Christopoulos K, Kroupis C, Lianidou ES
Clin Biochem. 2009
PubMed ID: 19747471
Breast cancer immunohistochemical features in young women with BRCA 1/2 mutations.
Zakhartseva LM, Gorovenko NG, Podolskaya SV, Anikusko NF, Lobanova OE, Pekur KA, Kropelnytskyi VA, Shurygina OV
Exp Oncol. 2009
PubMed ID: 19877382
BRCA1 and BRCA2 germline mutation analysis among Indian women from south India: identification of four novel mutations and high-frequency occurrence of 185delAG mutation.
Vaidyanathan K, Lakhotia S, Ravishankar HM, Tabassum U, Mukherjee G, Somasundaram K
J Biosci. 2009
PubMed ID: 19805903
Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.
McWilliams RR, Bamlet WR, de Andrade M, Rider DN, Couch FJ, Cunningham JM, Matsumoto ME, Rabe KG, Hammer TJ, Petersen GM
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19690177
Genotyping of frequent BRCA1/2 SNPs with unlabeled probes: a supplement to HRMCA mutation scanning, allowing the strong reduction of sequencing burden.
De Leeneer K, Coene I, Poppe B, De Paepe A, Claes K
J Mol Diagn. 2009
PubMed ID: 19644020
Cost-effectiveness of population-based BRCA1/2 testing and ovarian cancer prevention for Ashkenazi Jews: a call for dialogue.
Rubinstein WS, Jiang H, Dellefave L, Rademaker AW
Genet Med. 2009
PubMed ID: 19606050
Candidate serous cancer precursors in fallopian tube epithelium of BRCA1/2 mutation carriers.
Shaw PA, Rouzbahman M, Pizer ES, Pintilie M, Begley H
Mod Pathol. 2009
PubMed ID: 19543244
BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer.
Chen Y, Zhou J, Xu Y, Li Z, Wen X, Yao L, Xie Y, Deng D
Cancer Sci. 2009
PubMed ID: 19522853
The variants BRCA1 IVS6-1G>A and BRCA2 IVS15+1G>A lead to aberrant splicing of the transcripts.
Gutiérrez-Enríquez S, Coderch V, Masas M, Balmaña J, Diez O
Breast Cancer Res Treat. 2009
PubMed ID: 18712473
Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors.
Bane AL, Pinnaduwage D, Colby S, Bull SB, O'Malley FP, Andrulis IL
Breast Cancer Res Treat. 2009
PubMed ID: 18563556
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency.
Cao L, Xu X, Bunting SF, Liu J, Wang RH, Cao LL, Wu JJ, Peng TN, Chen J, Nussenzweig A, Deng CX, Finkel T
Mol Cell. 2009
PubMed ID: 19716796
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer.
Wang Y, Zhang H, Chen Y, Sun Y, Yang F, Yu W, Liang J, Sun L, Yang X, Shi L, Li R, Li Y, Zhang Y, Li Q, Yi X, Shang Y
Cell. 2009
PubMed ID: 19703393
BRCA1 interaction of centrosomal protein Nlp is required for successful mitotic progression.
Jin S, Gao H, Mazzacurati L, Wang Y, Fan W, Chen Q, Yu W, Wang M, Zhu X, Zhang C, Zhan Q
J Biol Chem. 2009
PubMed ID: 19509300
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Polymorphisms in the BRCA1 and ABCB1 genes modulate menopausal hormone therapy associated breast cancer risk in postmenopausal women.
The MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk
Breast Cancer Res Treat. 2009
PubMed ID: 19672706
Sensitivity to first-line chemotherapy for metastatic breast cancer in BRCA1 and BRCA2 mutation carriers.
Kriege M, Seynaeve C, Meijers-Heijboer H, Collee JM, Menke-Pluymers MB, Bartels CC, Tilanus-Linthorst MM, Blom J, Huijskens E, Jager A, van den Ouweland A, van Geel B, Hooning MJ, Brekelmans CT, Klijn JG
J Clin Oncol. 2009
PubMed ID: 19564533
MRG15 is a novel PALB2-interacting factor involved in homologous recombination.
Sy SM, Huen MS, Chen J
J Biol Chem. 2009
PubMed ID: 19553677
Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies.
Willers H, Taghian AG, Luo CM, Treszezamsky A, Sgroi DC, Powell SN
Mol Cancer Res. 2009
PubMed ID: 19671671
Missense polymorphisms in BRCA1 and BRCA2 and risk of breast and ovarian cancer.
Dombernowsky SL, Weischer M, Freiberg JJ, Bojesen SE, Tybjaerg-Hansen A, Nordestgaard BG
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19661094
Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.
Hussain SK, Mu LN, Cai L, Chang SC, Park SL, Oh SS, Wang Y, Goldstein BY, Ding BG, Jiang Q, Rao J, You NC, Yu SZ, Papp JC, Zhao JK, Wang H, Zhang ZF
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19661089
Comprehensive mutational analysis of BRCA1/BRCA2 for Korean breast cancer patients: evidence of a founder mutation.
Seong MW, Cho S, Noh DY, Han W, Kim SW, Park CM, Park HW, Kim SY, Kim JY, Park SS
Clin Genet. 2009
PubMed ID: 19656164
Breast-Conserving Surgery in BRCA1/2 Mutation Carriers: Are We Approaching an Answer?
Garcia-Etienne CA, Barile M, Gentilini OD, Botteri E, Rotmensz N, Sagona A, Farante G, Galimberti V, Luini A, Veronesi P, Bonanni B
Ann Surg Oncol. 2009
PubMed ID: 19649554
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers.
Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat ML, Gyorki DE, Ward T, Partanen A, Feleppa F, Huschtscha LI, Thorne HJ, kConFab, Fox SB, Yan M, French JD, Brown MA, Smyth GK, Visvader JE, Lindeman GJ
Nat Med. 2009
PubMed ID: 19648928
Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients.
Pugh TJ, Keyes M, Barclay L, Delaney A, Krzywinski M, Thomas D, Novik K, Yang C, Agranovich A, McKenzie M, Morris WJ, Olive PL, Marra MA, Moore RA
Clin Cancer Res. 2009
PubMed ID: 19638463
Haplotype of the C61G BRCA1 mutation in Polish and Jewish individuals.
Kaufman B, Laitman Y, Gronwald J, Lubinski J, Friedman E
Genet Test Mol Biomarkers. 2009
PubMed ID: 19594371
Common genetic variants in candidate genes and risk of familial lymphoid malignancies.
Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR
Br J Haematol. 2009
PubMed ID: 19573080
Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1.
Rusin M, Zajkowicz A, Butkiewicz D
Mech Ageing Dev. 2009
PubMed ID: 19559722
The central region of BRCA1 binds preferentially to supercoiled DNA.
Brázda V, Jagelska EB, Liao JC, Arrowsmith CH
J Biomol Struct Dyn. 2009
PubMed ID: 19492866
Polymorphisms in HPV E6/E7 protein interacted genes and risk of cervical cancer in Chinese women: a case-control analysis.
Zhou X, Han S, Wang S, Chen X, Dong J, Shi X, Xia Y, Wang X, Hu Z, Shen H
Gynecol Oncol. 2009
PubMed ID: 19482343
Mechanism of BRCA1-mediated inhibition of progesterone receptor transcriptional activity.
Katiyar P, Ma Y, Riegel A, Fan S, Rosen EM
Mol Endocrinol. 2009
PubMed ID: 19389812
Impact of BRCA mutations on female fertility and offspring sex ratio.
Moslehi R, Singh R, Lessner L, Friedman JM
Am J Hum Biol. 2009
PubMed ID: 19642207
Breast cancer susceptibility variants alter risks in familial disease.
Latif A, Hadfield KD, Roberts SA, Shenton A, Lalloo F, Black GC, Howell A, Evans DG, Newman WG
J Med Genet. 2009
PubMed ID: 19617217
Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.
Kweekel DM, Antonini NF, Nortier JW, Punt CJ, Gelderblom H, Guchelaar HJ
Br J Cancer. 2009
PubMed ID: 19536092
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
Prospective study of breast MRI in BRCA1 and BRCA2 mutation carriers: effect of mutation status on cancer incidence.
Shah P, Rosen M, Stopfer J, Siegfried J, Kaltman R, Mason B, Armstrong K, Nathanson KL, Schnall M, Domchek SM
Breast Cancer Res Treat. 2009
PubMed ID: 19609668
Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.
Rebbeck TR, Mitra N, Domchek SM, Wan F, Chuai S, Friebel TM, Panossian S, Spurdle A, Chenevix-Trench G, kConFab, Singer CF, Pfeiler G, Neuhausen SL, Lynch HT, Garber JE, Weitzel JN, Isaacs C, Couch F, Narod SA, Rubinstein WS, Tomlinson GE, Ganz PA, Olopade OI, Tung N, Blum JL, Greenberg R, Nathanson KL, Daly MB
Cancer Res. 2009
PubMed ID: 19584272
BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes.
Kouznetsova A, Wang H, Bellani M, Camerini-Otero RD, Jessberger R, Höög C
J Cell Sci. 2009
PubMed ID: 19531582
Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study.
Figueiredo JC, Haile RW, Bernstein L, Malone KE, Largent J, Langholz B, Lynch CF, Bertelsen L, Capanu M, Concannon P, Borg A, Børresen-Dale AL, Diep A, Teraoka S, Torngren T, Xue S, Bernstein JL
Breast Cancer Res Treat. 2009
PubMed ID: 19597986
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.
Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, Mortimer P, Swaisland H, Lau A, O'Connor MJ, Ashworth A, Carmichael J, Kaye SB, Schellens JH, de Bono JS
N Engl J Med. 2009
PubMed ID: 19553641
Contribution of BRCA1 germ-line mutations to breast cancer in Greece: a hospital-based study of 987 unselected breast cancer cases.
Armaou S, Pertesi M, Fostira F, Thodi G, Athanasopoulos PS, Kamakari S, Athanasiou A, Gogas H, Yannoukakos D, Fountzilas G, Konstantopoulou I
Br J Cancer. 2009
PubMed ID: 19491894
Elucidation of the transmission of a novel mutation in BRCA1 (1125delCT) in a family with multiple cases of breast cancer.
Razis E, Belogianni I, Siamanta V, Apessos A, Kyriakopoulou V, Papadopoulou E, Sariyanni M, Theofilopoulos D, Labropoulos S, Nasioulas G
Cancer Genomics Proteomics. 2009
PubMed ID: 19656998
Clinical characteristics of laryngeal cancer in BRCA-1 mutation carriers.
Jaworowska E, Tarnowska C, Lubiński J, Serrano-Fernández P, Huzarski T, Górski B, Masojć B, Jakubiszyn J, Korytowska A, Kram A, Rabczynski J, Lubiński J
Anticancer Res. 2009
PubMed ID: 19596949
Clinicopathological study of male breast carcinoma: 24 years of experience.
Shah P, Robbani I, Shah O
Ann Saudi Med. 2009
PubMed ID: 19584580
PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.
Zhang F, Fan Q, Ren K, Andreassen PR
Mol Cancer Res. 2009
PubMed ID: 19584259
Oral contraceptive use and BRCA penetrance: a case-only study.
Pasanisi P, Hédelin G, Berrino J, Chang-Claude J, Hermann S, Steel M, Haites N, Hart J, Peled R, Gafà L, Leggio L, Traina A, Amodio R, Primic-Zakelj M, Zadnik V, Veidebaum T, Tekkel M, Berrino F
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19549808
Promoter methylation patterns of ATM, ATR, BRCA1, BRCA2 and P53 as putative cancer risk modifiers in Jewish BRCA1/BRCA2 mutation carriers.
Kontorovich T, Cohen Y, Nir U, Friedman E
Breast Cancer Res Treat. 2009
PubMed ID: 18642075
No association of miscarriage and BRCA carrier status in Pakistani breast/ovarian cancer patients with a history of parental consanguinity.
Rashid MU, Torres D, Rasheed F, Sultan F, Shakoori AR, Amin A, Schlaefer K, Hamann U
Breast Cancer Res Treat. 2009
PubMed ID: 18574689
The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.
Barroso E, Pita G, Arias JI, Menendez P, Zamora P, Blanco M, Benitez J, Ribas G
Breast Cancer Res Treat. 2009
PubMed ID: 19536649
BRCA1 and BRCA2 germline mutations in Korean ovarian cancer patients.
Lim MC, Kang S, Seo SS, Kong SY, Lee BY, Lee SK, Park SY
J Cancer Res Clin Oncol. 2009
PubMed ID: 19499246
Breast cancer in young women (YBC): prevalence of BRCA1/2 mutations and risk of secondary malignancies across diverse racial groups.
Haffty BG, Choi DH, Goyal S, Silber A, Ranieri K, Matloff E, Lee MH, Nissenblatt M, Toppmeyer D, Moran MS
Ann Oncol. 2009
PubMed ID: 19491284
The BRCA1 3'-UTR: 5711+421T/T_5711+1286T/T genotype is a possible breast and ovarian cancer risk factor.
Pongsavee M, Yamkamon V, Dakeng S, O-charoenrat P, Smith DR, Saunders GF, Patmasiriwat P
Genet Test Mol Biomarkers. 2009
PubMed ID: 19405875
Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors.
Pulvers JN, Huttner WB
Development. 2009
PubMed ID: 19403657
Diagnostic guidelines for high-resolution melting curve (HRM) analysis: an interlaboratory validation of BRCA1 mutation scanning using the 96-well LightScanner.
van der Stoep N, van Paridon CD, Janssens T, Krenkova P, Stambergova A, Macek M, Matthijs G, Bakker E
Hum Mutat. 2009
PubMed ID: 19370767
The effect of symptom duration in epithelial ovarian cancer on prognostic factors.
Menczer J, Chetrit A, Sadetzki S, National Israel Ovarian Cancer Group
Arch Gynecol Obstet. 2009
PubMed ID: 18936947
Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women.
Huo X, Lu C, Huang X, Hu Z, Jin G, Ma H, Wang X, Qin J, Wang X, Shen H, Tang J
J Cancer Res Clin Oncol. 2009
PubMed ID: 19484476
BRCA1 and BRCA2 mutations in women of different ethnicities undergoing testing for hereditary breast-ovarian cancer.
Hall MJ, Reid JE, Burbidge LA, Pruss D, Deffenbaugh AM, Frye C, Wenstrup RJ, Ward BE, Scholl TA, Noll WW
Cancer. 2009
PubMed ID: 19241424
BRCA1 down-regulates cellular levels of reactive oxygen species.
Saha T, Rih JK, Rosen EM
FEBS Lett. 2009
PubMed ID: 19364506
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
[Analysis of K-ras, BRCA1/2, CHEK2 mutations and microsatellite markers (loss of heterozygosity at 9p, 17p and 18q) in sporadic pancreas adenocarcinomas]
Amosenko FA, Kazubskaia TP, Gromyko OE, Matveeva TI, Korchagina EL, Nasedkina TV, Gar'kavtseva RF, Kalinin VN
Mol Biol (Mosk). 2009
PubMed ID: 19548527
Methylation analysis of BRCA1, RASSF1, GSTP1 and EPHB2 promoters in prostate biopsies according to different degrees of malignancy.
Rabiau N, Thiam MO, Satih S, Guy L, Kemeny JL, Boiteux JP, Fontana L, Bignon YJ, Bernard-Gallon D
In Vivo. 2009
PubMed ID: 19454503
BRCA in breast cancer: ESMO clinical recommendations.
Balmaña J, Díez O, Castiglione M, ESMO Guidelines Working Group
Ann Oncol. 2009
PubMed ID: 19454451
A novel deletion of BRCA1 gene that eliminates the ATG initiation codon without affecting the promoter region.
Marino M, Rabacchi C, Simone ML, Medici V, Cortesi L, Calandra S
Clin Chim Acta. 2009
PubMed ID: 19393826
Association of hormone receptor status with grading, age of onset, and tumor size in BRCA1-associated breast cancer.
Graeser M, Bosse K, Brosig M, Engel C, Schmutzler RK, German Consortium for Hereditary Breast and Ovarian Cancer
Virchows Arch. 2009
PubMed ID: 19381686
Prevalence of BRCA1 and BRCA2 gene mutations in families with medium and high risk of breast and ovarian cancer in Brazil.
Esteves VF, Thuler LC, Amêndola LC, Koifman RJ, Koifman S, Frankel PP, Vieira RJ, Brazilian Network of Breast and Ovarian Familial Cancer Aggregation
Braz J Med Biol Res. 2009
PubMed ID: 19377795
BRCA1 breast cancer risk is modified by CYP19 polymorphisms in Ashkenazi Jews.
Raskin L, Lejbkowicz F, Barnett-Griness O, Dishon S, Almog R, Rennert G
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19366906
Cisplatin-damaged BRCA1 exhibits altered thermostability and transcriptional transactivation.
Ratanaphan A, Wasiksiri S, Canyuk B, Prasertsan P
Cancer Biol Ther. 2009
PubMed ID: 19270496
Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.
Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Méjean A, Desgrandchamps F, Lathrop M, Sarasin A, Benhamou S
Carcinogenesis. 2009
PubMed ID: 19237606
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
Large BRCA1 and BRCA2 genomic rearrangements in Danish high risk breast-ovarian cancer families.
Hansen TO, Jønson L, Albrechtsen A, Andersen MK, Ejlertsen B, Nielsen FC
Breast Cancer Res Treat. 2009
PubMed ID: 18546071
BRCA1 promoter methylation is associated with increased mortality among women with breast cancer.
Xu X, Gammon MD, Zhang Y, Bestor TH, Zeisel SH, Wetmur JG, Wallenstein S, Bradshaw PT, Garbowski G, Teitelbaum SL, Neugut AI, Santella RM, Chen J
Breast Cancer Res Treat. 2009
PubMed ID: 18521744
Prepubertal physical activity up-regulates estrogen receptor beta, BRCA1 and p53 mRNA expression in the rat mammary gland.
Wang M, Yu B, Westerlind K, Strange R, Khan G, Patil D, Boeneman K, Hilakivi-Clarke L
Breast Cancer Res Treat. 2009
PubMed ID: 18516675
A common Greenlandic Inuit BRCA1 RING domain founder mutation.
Hansen TV, Ejlertsen B, Albrechtsen A, Bergsten E, Bjerregaard P, Hansen T, Myrhøj T, Nielsen PB, Timmermans-Wielenga V, Andersen MK, Jønson L, Nielsen FC
Breast Cancer Res Treat. 2009
PubMed ID: 18500671
PALB2 is an integral component of the BRCA complex required for homologous recombination repair.
Sy SM, Huen MS, Chen J
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19369211
Basal Cytokeratin and Epidermal Growth Factor Receptor Expression Are Not Predictive of BRCA1 Mutation Status in Women With Triple-negative Breast Cancers.
Collins LC, Martyniak AJ, Kandel MJ, Stadler ZK, Masciari S, Miron A, Richardson AL, Schnitt SJ, Garber JE
Am J Surg Pathol. 2009
PubMed ID: 19390427
Parity and the risk of breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers.
Milne RL, Osorio A, Ramón Y Cajal T, Baiget M, Lasa A, Diaz-Rubio E, de la Hoya M, Caldés T, Teulé A, Lázaro C, Blanco I, Balmaña J, Sánchez-Ollé G, Vega A, Blanco A, Chirivella I, Esteban Cardeñosa E, Durán M, Velasco E, Martínez de Dueñas E, Tejada MI, Miramar MD, Calvo MT, Guillén-Ponce C, Salazar R, San Román C, Urioste M, Benítez J
Breast Cancer Res Treat. 2009
PubMed ID: 19370414
Genetic mutations associated with cigarette smoking in pancreatic cancer.
Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH
Cancer Res. 2009
PubMed ID: 19351817
High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer.
Holstege H, Joosse SA, van Oostrom CT, Nederlof PM, de Vries A, Jonkers J
Cancer Res. 2009
PubMed ID: 19336573
Inhibition of RNA polymerase III transcription by BRCA1.
Veras I, Rosen EM, Schramm L
J Mol Biol. 2009
PubMed ID: 19361418
[Correlation of BRCA1 and APC aberrant methylation with the response to anthracycline-based neoadjuvant chemotherapy in primary breast cancer].
Yuan P, Xu Y, Ouyang T, Wang TF, Fan ZQ, Fan T, Lin BY, Xie YT, Li JF
Zhonghua Zhong Liu Za Zhi. 2009
PubMed ID: 19615284
Molecular profiles of hereditary epithelial ovarian cancers and their implications for the biology of this disease.
Jazaeri AA
Mol Oncol. 2009
PubMed ID: 19383376
The contribution of BRCA1 and BRCA2 to ovarian cancer.
Ramus SJ, Gayther SA
Mol Oncol. 2009
PubMed ID: 19383375
Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management.
Lynch HT, Casey MJ, Snyder CL, Bewtra C, Lynch JF, Butts M, Godwin AK
Mol Oncol. 2009
PubMed ID: 19383374
Thematic issue on the molecular biology of hereditary ovarian cancer. Preface.
Tonin PN
Mol Oncol. 2009
PubMed ID: 19383373
Age at onset of bilateral breast cancer, the presence of hereditary BRCA1, BRCA2, CHEK2 gene mutations and positive family history of cancer.
Skasko E, Kluska A, Niwińska A, Kwiatkowska E, Bałabas A, Piatkowska M, Dabrowska M, Nowakowska D, Pieńkowski T
Onkologie. 2009
PubMed ID: 19372713
Premature senescence is a major response to DNA cross-linking agents in BRCA1-defective cells: implication for tailored treatments of BRCA1 mutation carriers.
Santarosa M, Del Col L, Tonin E, Caragnano A, Viel A, Maestro R
Mol Cancer Ther. 2009
PubMed ID: 19372557
Age-dependent penetrance of different germline mutations in the BRCA1 gene.
Al-Mulla F, Bland JM, Serratt D, Miller J, Chu C, Taylor GT
J Clin Pathol. 2009
PubMed ID: 19329713
Characterization of the c.190T>C missense mutation in BRCA1 codon 64 (Cys64Arg).
Willems P, Magri V, Cretnik M, Fasano M, Jakubowska A, Levanat S, Lubinski J, Marras E, Musani V, Thierens H, Vandersickel V, Perletti G, Vral A
Int J Oncol. 2009
PubMed ID: 19287957
A novel mechanism whereby BRCA1/1a/1b fine tunes the dynamic complex interplay between SUMO-dependent/independent activities of Ubc9 on E2-induced ERalpha activation/repression and degradation in breast cancer cells.
Xu J, Watkins T, Reddy A, Reddy ES, Rao VN
Int J Oncol. 2009
PubMed ID: 19287951
BRCA1 and implications for response to chemotherapy in ovarian cancer.
Quinn JE, Carser JE, James CR, Kennedy RD, Harkin DP
Gynecol Oncol. 2009
PubMed ID: 19168207
Liver X receptor ligands suppress ubiquitination and degradation of LXRalpha by displacing BARD1/BRCA1.
Kim KH, Yoon JM, Choi AH, Kim WS, Lee GY, Kim JB
Mol Endocrinol. 2009
PubMed ID: 19164445
PALB2 links BRCA1 and BRCA2 in the DNA-damage response.
Zhang F, Ma J, Wu J, Ye L, Cai H, Xia B, Yu X
Curr Biol. 2009
PubMed ID: 19268590
Familial Breast Cancer: Clinical Response to Induction Chemotherapy or Radiotherapy Related to BRCA1/2 Mutations Status.
Fourquet A, Stoppa-Lyonnet D, Kirova YM, Sigal-Zafrani B, Asselain B, for the Institut Curie Breast Cancer Study Group, Institut Curie Breast Ovary Cancer Risk Study Group
Am J Clin Oncol. 2009
PubMed ID: 19307946
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.
Wang B, Hurov K, Hofmann K, Elledge SJ
Genes Dev. 2009
PubMed ID: 19261749
MERIT40 facilitates BRCA1 localization and DNA damage repair.
Feng L, Huang J, Chen J
Genes Dev. 2009
PubMed ID: 19261748
MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks.
Shao G, Patterson-Fortin J, Messick TE, Feng D, Shanbhag N, Wang Y, Greenberg RA
Genes Dev. 2009
PubMed ID: 19261746
[Mutations in the BRCA1 gene (185delAG and 5382insC) are not present in any of the 30 breast cancer patients analyzed from eastern Colombia]
Sanabria MC, Muñioz G, Vargas CI
Biomedica. 2009
PubMed ID: 19753840
CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.
Vasilatos SN, Broadwater G, Barry WT, Baker JC, Lem S, Dietze EC, Bean GR, Bryson AD, Pilie PG, Goldenberg V, Skaar D, Paisie C, Torres-Hernandez A, Grant TL, Wilke LG, Ibarra-Drendall C, Ostrander JH, D'Amato NC, Zalles C, Jirtle R, Weaver VM, Seewaldt VL
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19258476
Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway.
Shimada M, Sagae R, Kobayashi J, Habu T, Komatsu K
Cancer Res. 2009
PubMed ID: 19244116
Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner.
Schayek H, Haugk K, Sun S, True LD, Plymate SR, Werner H
Clin Cancer Res. 2009
PubMed ID: 19223505
Histopathological criteria and selection algorithms for BRCA1 genetic testing.
Gadzicki D, Schubert A, Fischer C, Milde S, Lehmann U, Steinemann D, Lück HJ, Kreipe H, Schlegelberger B
Cancer Genet Cytogenet. 2009
PubMed ID: 19215791
Association of loss of BRCA1 expression with centrosome aberration in human breast cancer.
Shimomura A, Miyoshi Y, Taguchi T, Tamaki Y, Noguchi S
J Cancer Res Clin Oncol. 2009
PubMed ID: 18813953
Polymorphisms in BRCA2 resulting in aberrant codon-usage and their analysis on familial breast cancer risk.
Yang R, Chen B, Hemminki K, Wappenschmidt B, Engel C, Sutter C, Ditsch N, Weber BH, Niederacher D, Arnold N, Meindl A, Bartram CR, Schmutzler RK, Burwinkel B
Breast Cancer Res Treat. 2009
PubMed ID: 19229607
Altered proliferation and differentiation properties of primary mammary epithelial cells from BRCA1 mutation carriers.
Burga LN, Tung NM, Troyan SL, Bostina M, Konstantinopoulos PA, Fountzilas H, Spentzos D, Miron A, Yassin YA, Lee BT, Wulf GM
Cancer Res. 2009
PubMed ID: 19190334
Time to stop ovarian cancer screening in BRCA1/2 mutation carriers?
van der Velde NM, Mourits MJ, Arts HJ, de Vries J, Leegte BK, Dijkhuis G, Oosterwijk JC, de Bock GH
Int J Cancer. 2009
PubMed ID: 19035463
The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovarian cancer.
Weberpals J, Garbuio K, O'Brien A, Clark-Knowles K, Doucette S, Antoniouk O, Goss G, Dimitroulakos J
Int J Cancer. 2009
PubMed ID: 19035454
CASP8 D302H polymorphism delays the age of onset of breast cancer in BRCA1 and BRCA2 carriers.
Palanca Suela S, Esteban Cardeñosa E, Barragán González E, de Juan Jiménez I, Chirivella González I, Segura Huerta A, Guillén Ponce C, Martínez de Dueñas E, Montalar Salcedo J, Castel Sánchez V, Bolufer Gilabert P, On Behalf of the Group for Assessment of Hereditary Cancer of Valencia Community
Breast Cancer Res Treat. 2009
PubMed ID: 19214744
Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1.
Gonzalez ME, Li X, Toy K, DuPrie M, Ventura AC, Banerjee M, Ljungman M, Merajver SD, Kleer CG
Oncogene. 2009
PubMed ID: 19079346
A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women.
Wang Z, Xu Y, Tang J, Ma H, Qin J, Lu C, Wang X, Hu Z, Wang X, Shen H
Breast Cancer Res Treat. 2009
PubMed ID: 19205873
Fertility in women with BRCA mutations: a case-control study.
Pal T, Keefe D, Sun P, Narod SA, the Hereditary Breast Cancer Clinical Study Group
Fertil Steril. 2009
PubMed ID: 19200971
Estimated risk of radiation-induced breast cancer from mammographic screening for young BRCA mutation carriers.
Berrington de Gonzalez A, Berg CD, Visvanathan K, Robson M
J Natl Cancer Inst. 2009
PubMed ID: 19176458
Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors.
Arnold JM, Choong DY, Thompson ER, kConFab, Waddell N, Lindeman GJ, Visvader JE, Campbell IG, Chenevix-Trench G
Breast Cancer Res Treat. 2009
PubMed ID: 19189213
[Analysis of BRCA1 gene mutations in patients with early-onset breast cancer and their affected relatives in Guangdong province]
Zhou J, Rao NY, Li SR, Jin L, Jia WJ, Gong C, Yu FY, Su FX, Song EW, Shao ZM
Nan Fang Yi Ke Da Xue Xue Bao. 2009
PubMed ID: 19246281
Reproductive and hormonal factors, and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: results from the International BRCA1/2 Carrier Cohort Study.
Antoniou AC, Rookus M, Andrieu N, Brohet R, Chang-Claude J, Peock S, Cook M, Evans DG, Eeles R, EMBRACE, Nogues C, Faivre L, Gesta P, GENEPSO, van Leeuwen FE, Ausems MG, Osorio A, GEO-HEBON, Caldes T, Simard J, Lubinski J, Gerdes AM, Olah E, Fürhauser C, Olsson H, Arver B, Radice P, Easton DF, Goldgar DE
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19190154
Associations of high-grade prostate cancer with BRCA1 and BRCA2 founder mutations.
Agalliu I, Gern R, Leanza S, Burk RD
Clin Cancer Res. 2009
PubMed ID: 19188187
Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2.
Ryser S, Dizin E, Jefford CE, Delaval B, Gagos S, Christodoulidou A, Krause KH, Birnbaum D, Irminger-Finger I
Cancer Res. 2009
PubMed ID: 19176389
Prolactin blocks nuclear translocation of VDR by regulating its interaction with BRCA1 in osteosarcoma cells.
Deng C, Ueda E, Chen KE, Bula C, Norman AW, Luben RA, Walker AM
Mol Endocrinol. 2009
PubMed ID: 19074549
Absence of germline BRCA1 mutations in familial pancreatic cancer patients.
Axilbund JE, Argani P, Kamiyama M, Palmisano E, Raben M, Borges M, Brune KA, Goggins M, Hruban RH, Klein AP
Cancer Biol Ther. 2009
PubMed ID: 19029836
Histone ubiquitination associates with BRCA1-dependent DNA damage response.
Wu J, Huen MS, Lu LY, Ye L, Dou Y, Ljungman M, Chen J, Yu X
Mol Cell Biol. 2009
PubMed ID: 19015238
BRCA1 2080insA mutation in familial breast cancer.
Alansari AS, Al-Moundhri M, Al-Nabhani MM, Al-Zidjali SA
Breast Cancer Res Treat. 2009
PubMed ID: 18340530
Decreased BRCA1 confers tamoxifen resistance in breast cancer cells by altering estrogen receptor-coregulator interactions.
Wen J, Li R, Lu Y, Shupnik MA
Oncogene. 2009
PubMed ID: 18997820
Breast cancer risk in relation to the joint effect of BRCA mutations and diet diversity.
Ghadirian P, Narod S, Fafard E, Costa M, Robidoux A, Nkondjock A
Breast Cancer Res Treat. 2009
PubMed ID: 19165595
BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma.
Ferrone CR, Levine DA, Tang LH, Allen PJ, Jarnagin W, Brennan MF, Offit K, Robson ME
J Clin Oncol. 2009
PubMed ID: 19064968
Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex.
Ray H, Suau F, Vincent A, Dalla Venezia N
Biochem Biophys Res Commun. 2009
PubMed ID: 19061860
High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors.
Manié E, Vincent-Salomon A, Lehmann-Che J, Pierron G, Turpin E, Warcoin M, Gruel N, Lebigot I, Sastre-Garau X, Lidereau R, Remenieras A, Feunteun J, Delattre O, de Thé H, Stoppa-Lyonnet D, Stern MH
Cancer Res. 2009
PubMed ID: 19147582
Analysis of a set of missense, frameshift, and in-frame deletion variants of BRCA1.
Carvalho M, Pino MA, Karchin R, Beddor J, Godinho-Netto M, Mesquita RD, Rodarte RS, Vaz DC, Monteiro VA, Manoukian S, Colombo M, Ripamonti CB, Rosenquist R, Suthers G, Borg A, Radice P, Grist SA, Monteiro AN, Billack B
Mutat Res. 2009
PubMed ID: 18992264
[Relationship between mutation of BRCA1 and susceptibility to early onset of breast cancer]
Meng J, Shi YR, Niu RF, Fu L
Zhonghua Yi Xue Za Zhi. 2009
PubMed ID: 19489266
A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.
Vineis P, Manuguerra M, Kavvoura FK, Guarrera S, Allione A, Rosa F, Di Gregorio A, Polidoro S, Saletta F, Ioannidis JP, Matullo G
J Natl Cancer Inst. 2009
PubMed ID: 19116388
[The prevalence of BRCA1 mutations among families at high-risk of breast and ovarian cancer in province of Malopolska between 2004-2009]
Blecharz P, Szatkowski W, Klimek M, Urbański K
Przegl Lek. 2009
PubMed ID: 20514903
Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p53.
Quinn BA, Brake T, Hua X, Baxter-Jones K, Litwin S, Ellenson LH, Connolly DC
PLoS One. 2009
PubMed ID: 20046879
Conditional inactivation of Brca1, p53 and Rb in mouse ovaries results in the development of leiomyosarcomas.
Clark-Knowles KV, Senterman MK, Collins O, Vanderhyden BC
PLoS One. 2009
PubMed ID: 20046869
Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.
Holmes MV, Shah T, Vickery C, Smeeth L, Hingorani AD, Casas JP
PLoS One. 2009
PubMed ID: 19956635
Prognostic relevance of promoter hypermethylation of multiple genes in breast cancer patients.
Sharma G, Mirza S, Yang YH, Parshad R, Hazrah P, Datta Gupta S, Ralhan R
Cell Oncol. 2009
PubMed ID: 19940364
Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study.
Thompson DJ, Leach MO, Kwan-Lim G, Gayther SA, Ramus SJ, Warsi I, Lennard F, Khazen M, Bryant E, Reed S, Boggis CR, Evans DG, Eeles RA, Easton DF, Warren RM, UK study of MRI screening for breast cancer in women at high risk (MARIBS)
Breast Cancer Res. 2009
PubMed ID: 19903338
Mutational analysis of BRCA1 and BRCA2 genes in Mexican breast cancer patients.
Vidal-Millán S, Taja-Chayeb L, Gutiérrez-Hernández O, Ramírez Ugalde MT, Robles-Vidal C, Bargallo-Rocha E, Mohar-Betancourt A, Dueñas-González A
Eur J Gynaecol Oncol. 2009
PubMed ID: 19899408
Loss of heterozygosity at BRCA1/2 loci in hereditary and sporadic ovarian cancers.
Brozek I, Ochman K, Debniak J, Morzuch L, Ratajska M, Stepnowska M, Stukan M, Emerich J, Limon J
J Appl Genet. 2009
PubMed ID: 19875889
Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers.
Neuhausen SL, Brummel S, Ding YC, Singer CF, Pfeiler G, Lynch HT, Nathanson KL, Rebbeck TR, Garber JE, Couch F, Weitzel J, Narod SA, Ganz PA, Daly MB, Godwin AK, Isaacs C, Olopade OI, Tomlinson G, Rubinstein WS, Tung N, Blum JL, Gillen DL
Breast Cancer Res. 2009
PubMed ID: 19843326
MicroRNA profiling of BRCA1/2 mutation-carrying and non-mutation-carrying high-grade serous carcinomas of ovary.
Lee CH, Subramanian S, Beck AH, Espinosa I, Senz J, Zhu SX, Huntsman D, van de Rijn M, Gilks CB
PLoS One. 2009
PubMed ID: 19798417
BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses.
Li H, Sekine M, Seng S, Avraham S, Avraham HK
PLoS One. 2009
PubMed ID: 19768112
Role of BRCA1, HSD17B1 and HSD17B2 methylation in breast cancer tissue.
Bhavani V, Srinivasulu M, Ahuja YR, Hasan Q
Cancer Biomark. 2009
PubMed ID: 19729830
BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A.
Puppe J, Drost R, Liu X, Joosse SA, Evers B, Cornelissen-Steijger P, Nederlof P, Yu Q, Jonkers J, van Lohuizen M, Pietersen AM
Breast Cancer Res. 2009
PubMed ID: 19709408
BRCA1 expression in invasive breast carcinomas and clinicopathological correlations.
Comănescu M, Popescu CF
Rom J Morphol Embryol. 2009
PubMed ID: 19690768
A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.
van Wijk SJ, de Vries SJ, Kemmeren P, Huang A, Boelens R, Bonvin AM, Timmers HT
Mol Syst Biol. 2009
PubMed ID: 19690564
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Low contribution of BRCA1/2 genomic rearrangement to high-risk breast cancer in the Korean population.
Seong MW, Cho SI, Noh DY, Han W, Kim SW, Park CM, Park HW, Kim SY, Kim JY, Park SS
Fam Cancer. 2009
PubMed ID: 19669600
Molecular genetics analysis of hereditary breast and ovarian cancer patients in India.
Soumittra N, Meenakumari B, Parija T, Sridevi V, Nancy KN, Swaminathan R, Rajalekshmy KR, Majhi U, Rajkumar T
Hered Cancer Clin Pract. 2009
PubMed ID: 19656415
Clinical significance of epigenetic inactivation of hMLH1 and BRCA1 in Tunisian patients with invasive breast carcinoma.
Karray-Chouayekh S, Trifa F, Khabir A, Boujelbane N, Sellami-Boudawara T, Daoud J, Frikha M, Gargouri A, Mokdad-Gargouri R
J Biomed Biotechnol. 2009
PubMed ID: 19644562
A role of BRCA1 and BRCA2 germline mutations in breast cancer susceptibility within Sardinian population.
Palomba G, Loi A, Uras A, Fancello P, Piras G, Gabbas A, Cossu A, Budroni M, Contu A, Tanda F, Farris A, Orrù S, Floris C, Pisano M, Lovicu M, Santona MC, Landriscina G, Crisponi L, Palmieri G, Monne M
BMC Cancer. 2009
PubMed ID: 19619314
[Analysis of polymorphisms in genes of insulin receptor substrate-1 and enzymes involved in estrogen biosynthesis and metabolism among breast cancer patients with BRCA1 mutations]
Bershteĭn LM, Ulybina IuM, Pozharisskiĭ KM, Imianitov EN
Vopr Onkol. 2009
PubMed ID: 19514368
A high frequent BRCA1 founder mutation identified in the Greenlandic population.
Harboe TL, Eiberg H, Kern P, Ejlertsen B, Nedergaard L, Timmermans-Wielenga V, Nielsen IM, Bisgaard ML
Fam Cancer. 2009
PubMed ID: 19504351
Aromatase expression is increased in BRCA1 mutation carriers.
Chand AL, kConFab, Simpson ER, Clyne CD
BMC Cancer. 2009
PubMed ID: 19445691
Misbehaviour of XIST RNA in breast cancer cells.
Sirchia SM, Tabano S, Monti L, Recalcati MP, Gariboldi M, Grati FR, Porta G, Finelli P, Radice P, Miozzo M
PLoS One. 2009
PubMed ID: 19440381
Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression.
Rosell R, Perez-Roca L, Sanchez JJ, Cobo M, Moran T, Chaib I, Provencio M, Domine M, Sala MA, Jimenez U, Diz P, Barneto I, Macias JA, de Las Peñas R, Catot S, Isla D, Sanchez JM, Ibeas R, Lopez-Vivanco G, Oramas J, Mendez P, Reguart N, Blanco R, Taron M
PLoS One. 2009
PubMed ID: 19415121
Survival in Norwegian BRCA1 mutation carriers with breast cancer.
Hagen AI, Tretli S, Mæhle L, Apold J, Vedå N, Møller P
Hered Cancer Clin Pract. 2009
PubMed ID: 19366445
Methylation not a frequent "second hit" in tumors with germline BRCA mutations.
Dworkin AM, Spearman AD, Tseng SY, Sweet K, Toland AE
Fam Cancer. 2009
PubMed ID: 19340607
High frequency of BRCA1, but not CHEK2 or NBS1 (NBN), founder mutations in Russian ovarian cancer patients.
Suspitsin EN, Sherina NY, Ponomariova DN, Sokolenko AP, Iyevleva AG, Gorodnova TV, Zaitseva OA, Yatsuk OS, Togo AV, Tkachenko NN, Shiyanov GA, Lobeiko OS, Krylova NY, Matsko DE, Maximov SY, Urmancheyeva AF, Porhanova NV, Imyanitov EN
Hered Cancer Clin Pract. 2009
PubMed ID: 19338682
The prevalence of BRCA1 mutations among young women with triple-negative breast cancer.
Young SR, Pilarski RT, Donenberg T, Shapiro C, Hammond LS, Miller J, Brooks KA, Cohen S, Tenenholz B, Desai D, Zandvakili I, Royer R, Li S, Narod SA
BMC Cancer. 2009
PubMed ID: 19298662
XPG mRNA expression levels modulate prognosis in resected non-small-cell lung cancer in conjunction with BRCA1 and ERCC1 expression.
Bartolucci R, Wei J, Sanchez JJ, Perez-Roca L, Chaib I, Puma F, Farabi R, Mendez P, Roila F, Okamoto T, Taron M, Rosell R
Clin Lung Cancer. 2009
PubMed ID: 19289372
Potential excess mortality in BRCA1/2 mutation carriers beyond breast, ovarian, prostate, and pancreatic cancers, and melanoma.
Mai PL, Chatterjee N, Hartge P, Tucker M, Brody L, Struewing JP, Wacholder S
PLoS One. 2009
PubMed ID: 19277124
Ovarian epithelial dysplasia and prophylactic oophorectomy for genetic risk.
Chêne G, Penault-Llorca F, Le Bouëdec G, Mishellany F, Dauplat MM, Jaffeux P, Aublet-Cuvelier B, Pouly JL, Déchelotte P, Dauplat J
Int J Gynecol Cancer. 2009
PubMed ID: 19258944
Role of BRCA2 mutation status on overall survival among breast cancer patients from Sardinia.
Budroni M, Cesaraccio R, Coviello V, Sechi O, Pirino D, Cossu A, Tanda F, Pisano M, Palomba G, Palmieri G
BMC Cancer. 2009
PubMed ID: 19232099
Effects of the single nucleotide polymorphism at MDM2 309 on breast cancer patients with/without BRCA1/2 mutations.
Nechushtan H, Hamburger T, Mendelson S, Kadouri L, Sharon N, Pikarsky E, Peretz T
BMC Cancer. 2009
PubMed ID: 19226467
A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes based on cancer family history.
Gómez García EB, Oosterwijk JC, Timmermans M, van Asperen CJ, Hogervorst FB, Hoogerbrugge N, Oldenburg R, Verhoef S, Dommering CJ, Ausems MG, van Os TA, van der Hout AH, Ligtenberg M, van den Ouweland A, van der Luijt RB, Wijnen JT, Gille JJ, Lindsey PJ, Devilee P, Blok MJ, Vreeswijk MP
Breast Cancer Res. 2009
PubMed ID: 19200354
Genetic sequence variations of BRCA1-interacting genes AURKA, BAP1, BARD1 and DHX9 in French Canadian Families with high risk of breast cancer.
Guénard F, Labrie Y, Ouellette G, Joly Beauparlant C, Durocher F
J Hum Genet. 2009
PubMed ID: 19197335
ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage in human oocytes.
Garcia-Cruz R, Roig I, Robles P, Scherthan H, Garcia Caldés M
Reprod Biomed Online. 2009
PubMed ID: 19146767
Penetrance of BRCA1/BRCA2 specific gene mutations in Iranian women with breast cancer.
Hashemian AH, Hajizadeh E, Kazemnejad A, Atri M, Mehdipour P
Saudi Med J. 2009
PubMed ID: 19139771
Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
Mavaddat N, Dunning AM, Ponder BA, Easton DF, Pharoah PD
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19124506
Haplotype and quantitative transcript analyses of Portuguese breast/ovarian cancer families with the BRCA1 R71G founder mutation of Galician origin.
Santos C, Peixoto A, Rocha P, Vega A, Soares MJ, Cerveira N, Bizarro S, Pinheiro M, Pereira D, Rodrigues H, Castro F, Henrique R, Teixeira MR
Fam Cancer. 2009
PubMed ID: 19123044
BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity.
Nishikawa H, Wu W, Koike A, Kojima R, Gomi H, Fukuda M, Ohta T
Cancer Res. 2009
PubMed ID: 19117993
The 4154delA mutation carriers in the BRCA1 gene share a common ancestry.
Ozolina S, Sinicka O, Jankevics E, Inashkina I, Lubinski J, Gorski B, Gronwald J, Nasedkina T, Fedorova O, Lyubchenko L, Tihomirova L
Fam Cancer. 2009
PubMed ID: 19067236
Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer.
Wang SS, Bratti MC, Rodríguez AC, Herrero R, Burk RD, Porras C, González P, Sherman ME, Wacholder S, Lan ZE, Schiffman M, Chanock SJ, Hildesheim A
J Infect Dis. 2009
PubMed ID: 19012493
BRCA1 expression and molecular alterations in familial breast cancer.
Mangia A, Chiriatti A, Tommasi S, Menolascina F, Petroni S, Zito FA, Simone G, Schittulli F, Paradiso A
Histol Histopathol. 2009
PubMed ID: 19012246
Expression profile of BRCA1 and BRCA2 genes in premenopausal Mexican women with breast cancer: clinical and immunohistochemical correlates.
Loredo-Pozos G, Chiquete E, Oceguera-Villanueva A, Panduro A, Siller-López F, Ramos-Márquez ME
Med Oncol. 2009
PubMed ID: 19012002
A novel BRCA1 mutation in a Spanish patient with ovarian cancer.
Salgado J, Gil C, Robles M, García-Foncillas J
Breast Cancer Res Treat. 2009
PubMed ID: 18278587
Is BRCA1-5083del19, identified in breast cancer patients of Sicilian origin, a Calabrian founder mutation?
Russo A, Calò V, Bruno L, Schirò V, Agnese V, Cascio S, Foddai E, Fanale D, Rizzo S, Di Gaudio F, Gulotta E, Surmacz E, Di Fede G, Bazan V
Breast Cancer Res Treat. 2009
PubMed ID: 18228134
E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks.
Reid LJ, Shakya R, Modi AP, Lokshin M, Cheng JT, Jasin M, Baer R, Ludwig T
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19088202
Effect of BRCA1 haplotype on survival of non-small-cell lung cancer patients treated with platinum-based chemotherapy.
Kim HT, Lee JE, Shin ES, Yoo YK, Cho JH, Yun MH, Kim YH, Kim SK, Kim HJ, Jang TW, Kwak SM, Kim CS, Ryu JS
J Clin Oncol. 2008
PubMed ID: 19018088
Negative Regulation of AKT Activation by BRCA1.
Xiang T, Ohashi A, Huang Y, Pandita TK, Ludwig T, Powell SN, Yang Q
Cancer Res. 2008
PubMed ID: 19074868
No evidence that GATA3 rs570613 SNP modifies breast cancer risk.
Johnatty SE, Couch FJ, Fredericksen Z, Tarrell R, Spurdle AB, Beesley J, Chen X, kConFab Investigators, AOCS Group, The Swedish BRCA1 and BRCA2 Study Collaborators, Gschwantler-Kaulich D, Singer CF, Fuerhauser C, Fink-Retter A, Domchek SM, Nathanson KL, Pankratz VS, Lindor NM, Godwin AK, Caligo MA, Hopper J, Southey MC, Giles GG, Justenhoven C, Brauch H, Hamann U, Ko YD, Heikkinen T, Aaltonen K, Aittomäki K, Blomqvist C, Nevanlinna H, Hall P, Czene K, Liu J, Peock S, Cook M, Platte R, Gareth Evans D, Lalloo F, Eeles R, Pichert G, Eccles D, Davidson R, Cole T, Cook J, Douglas F, Chu C, Hodgson S, Paterson J, Hogervorst FB, Rookus MA, Seynaeve C, Wijnen J, Vreeswijk M, Ligtenberg M, van der Luijt RB, van Os TA, Gille HJ, Blok MJ, HEBON, Issacs C, Humphreys MK, McGuffog L, Healey S, Sinilnikova O, Antoniou AC, Easton DF, Chenevix-Trench G, on behalf of the Breast Cancer Association Consortium and the Consortium of Investigators of Modifiers of BRCA1/2
Breast Cancer Res Treat. 2008
PubMed ID: 19082709
Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosis.
Yeung BH, Kwan BW, He QY, Lee AS, Liu J, Wong AS
Oncogene. 2008
PubMed ID: 18776923
Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.
Bartkova J, Tommiska J, Oplustilova L, Aaltonen K, Tamminen A, Heikkinen T, Mistrik M, Aittomäki K, Blomqvist C, Heikkilä P, Lukas J, Nevanlinna H, Bartek J
Mol Oncol. 2008
PubMed ID: 19383352
BRCA1 mutations contribute to cell motility and invasion by affecting its main regulators.
Yasmeen A, Liu W, Dekhil H, Kassab A, Aloyz R, Foulkes WD, Al Moustafa AE
Cell Cycle. 2008
PubMed ID: 19098453
A BRCA1 mutation is not associated with increased indicators of oxidative stress.
Kotsopoulos J, Shen H, Rao AV, Poll A, Ainsworth P, Fleshner N, Narod SA
Clin Breast Cancer. 2008
PubMed ID: 19073505
Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064572
A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis.
Triplett AA, Montagna C, Wagner KU
Neoplasia. 2008
PubMed ID: 19048111
Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80.
Wei L, Lan L, Hong Z, Yasui A, Ishioka C, Chiba N
Mol Cell Biol. 2008
PubMed ID: 18936166
Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.
Maggi LB, Kuchenruether M, Dadey DY, Schwope RM, Grisendi S, Townsend RR, Pandolfi PP, Weber JD
Mol Cell Biol. 2008
PubMed ID: 18809582
BRCA1 is regulated by Chk2 in response to spindle damage.
Chabalier-Taste C, Racca C, Dozier C, Larminat F
Biochim Biophys Acta. 2008
PubMed ID: 18804494
Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas.
Becker K, Goldberg M, Helmbold P, Holbach LM, Loeffler KU, Ballhausen WG
Br J Dermatol. 2008
PubMed ID: 18717684
AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51.
Plo I, Laulier C, Gauthier L, Lebrun F, Calvo F, Lopez BS
Cancer Res. 2008
PubMed ID: 19010915
High risk for ovarian cancer in a prospective series is restricted to BRCA1/2 mutation carriers.
Maehle L, Apold J, Paulsen T, Hagen B, Løvslett K, Fiane B, Van Ghelue M, Clark N, Møller P
Clin Cancer Res. 2008
PubMed ID: 19010876
NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway.
Wilson KA, Stern DF
Cell Cycle. 2008
PubMed ID: 19001859
Skewed X chromosome inactivation and breast and ovarian cancer status: evidence for X-linked modifiers of BRCA1.
Lose F, Duffy DL, Kay GF, Kedda MA, Spurdle AB, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Australian Ovarian Cancer Study Management Group
J Natl Cancer Inst. 2008
PubMed ID: 18957670
Is there any relationship between BRCA1 gene mutation and pancreatic cancer development?
Lawniczak M, Gawin A, Białek A, Lubiński J, Starzyńska T
Pol Arch Med Wewn. 2008
PubMed ID: 19140568
Cloning and functional identification of two novel BRCA1 splicing variants.
Miao L, Cao Z, Shen C, Gu M, Liu W, Li H, Zheng C
Biochemistry (Mosc). 2008
PubMed ID: 19120025
BRCA1: a new genomic marker for non-small-cell lung cancer.
Reguart N, Cardona AF, Carrasco E, Gomez P, Taron M, Rosell R
Clin Lung Cancer. 2008
PubMed ID: 19073515
Effect of reproductive factors and oral contraceptives on breast cancer risk in BRCA1/2 mutation carriers and noncarriers: results from a population-based study.
Lee E, Ma H, McKean-Cowdin R, Van Den Berg D, Bernstein L, Henderson BE, Ursin G
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18990759
BRCA1 5083del19 mutant allele selectively up-regulates periostin expression in vitro and in vivo.
Quaresima B, Romeo F, Faniello MC, Di Sanzo M, Liu CG, Lavecchia A, Taccioli C, Gaudio E, Baudi F, Trapasso F, Croce CM, Cuda G, Costanzo F
Clin Cancer Res. 2008
PubMed ID: 18980973
Occult fallopian tube cancer in a patient with BRCA1 breast cancer.
Brown JV, Epstein HD, Mattison JN, Micha JP, Rettenmaier MA, Goldstein BH
J Minim Invasive Gynecol. 2008
PubMed ID: 18971141
Mitotic delay in lymphocytes from BRCA1 heterozygotes unable to reduce the radiation-induced chromosomal damage.
Febrer E, Mestres M, Caballín MR, Barrios L, Ribas M, Gutiérrez-Enríquez S, Alonso C, Ramón y Cajal T, Francesc Barquinero J
DNA Repair (Amst). 2008
PubMed ID: 18765304
Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer.
Suijkerbuijk KP, Fackler MJ, Sukumar S, van Gils CH, van Laar T, van der Wall E, Vooijs M, van Diest PJ
Ann Oncol. 2008
PubMed ID: 18647968
BRCA1 transcriptional activity is enhanced by interactions between its AD1 domain and AhR.
Kang HJ, Kim HJ, Cho CH, Hu Y, Li R, Bae I
Cancer Chemother Pharmacol. 2008
PubMed ID: 18259752
Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia.
Smart CE, Clarke C, Brooks KM, Raghavendra A, Brewster BL, French JD, Hetherington R, Fleming JS, Rothnagel JA, Wainwright B, Lakhani SR, Brown MA
Breast Cancer Res Treat. 2008
PubMed ID: 18095153
Breast cancer risk and the BRCA1 interacting protein CTIP.
Gorringe KL, Choong DY, Lindeman GJ, Visvader JE, Campbell IG
Breast Cancer Res Treat. 2008
PubMed ID: 18095152
Twenty-three novel BRCA1 and BRCA2 sequence alterations in breast and/or ovarian cancer families of Eastern Spain.
Esteban Cardeñosa E, Bolufer Gilabert P, Palanca Suela S, Oltra Soler S, Barragán González E, Velasco Sampedro E, Chirivella González I, Segura Huerta A, Guillén Ponce C, Martínez de Dueñas E, Group for Assessment of Hereditary Cancer of Valencia Community
Breast Cancer Res Treat. 2008
PubMed ID: 18060494
Identification of a novel BRCA1 large genomic rearrangement in a Spanish breast/ovarian cancer family.
Palanca Suela S, Esteban Cardeñosa E, Barragán González E, Oltra Soler S, de Juan Jiménez I, Chirivella González I, Segura Huerta A, Guillén Ponce C, Martínez de Dueñas E, Bolufer Gilabert P, Group for Assessment of Hereditary Cancer of Valencia Community
Breast Cancer Res Treat. 2008
PubMed ID: 18060491
"BRCAness" Syndrome in Ovarian Cancer: A Case-Control Study Describing the Clinical Features and Outcome of Patients With Epithelial Ovarian Cancer Associated With BRCA1 and BRCA2 Mutations.
Tan DS, Rothermundt C, Thomas K, Bancroft E, Eeles R, Shanley S, Ardern-Jones A, Norman A, Kaye SB, Gore ME
J Clin Oncol. 2008
PubMed ID: 18955455
Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers.
Toyama T, Yamashita H, Kondo N, Okuda K, Takahashi S, Sasaki H, Sugiura H, Iwase H, Fujii Y
BMC Cancer. 2008
PubMed ID: 18950515
Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: A two-stage Spanish case-control study.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A
Gynecol Oncol. 2008
PubMed ID: 18950845
The effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other deleterious CHEK2 or BRCA1 mutations.
Cybulski C, Górski B, Huzarski T, Byrski T, Gronwald J, Debniak T, Wokolorczyk D, Jakubowska A, Serrano-Fernández P, Dork T, Narod SA, Lubinski J
J Med Genet. 2008
PubMed ID: 18930998
Ovarian cancer patient with germline mutations in both BRCA1 and NBN genes.
Porhanova NV, Sokolenko AP, Sherina NY, Ponomariova DN, Tkachenko NN, Matsko DE, Imyanitov EN
Cancer Genet Cytogenet. 2008
PubMed ID: 18940477
Prevalence and characteristics of pancreatic cancer in families with BRCA1 and BRCA2 mutations.
Kim DH, Crawford B, Ziegler J, Beattie MS
Fam Cancer. 2008
PubMed ID: 18855126
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.
Wang RH, Zheng Y, Kim HS, Xu X, Cao L, Luhasen T, Lee MH, Xiao C, Vassilopoulos A, Chen W, Gardner K, Man YG, Hung MC, Finkel T, Deng CX
Mol Cell. 2008
PubMed ID: 18851829
Mutation screening of the BRCA1 gene in sporadic breast cancer in southern Chinese populations.
Haitian Z, Yunfei L, Jian Z, Jian L, Qinghua L, Fuqiang W
Breast. 2008
PubMed ID: 18835712
Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma.
Wang SS, Maurer MJ, Morton LM, Habermann TM, Davis S, Cozen W, Lynch CF, Severson RK, Rothman N, Chanock SJ, Hartge P, Cerhan JR
Leukemia. 2008
PubMed ID: 18830263
Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer.
Sugano K, Nakamura S, Ando J, Takayama S, Kamata H, Sekiguchi I, Ubukata M, Kodama T, Arai M, Kasumi F, Hirai Y, Ikeda T, Jinno H, Kitajima M, Aoki D, Hirasawa A, Takeda Y, Yazaki K, Fukutomi T, Kinoshita T, Tsunematsu R, Yoshida T, Izumi M, Umezawa S, Yagata H, Komatsu H, Arimori N, Matoba N, Gondo N, Yokoyama S, Miki Y
Cancer Sci. 2008
PubMed ID: 19016756
Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.
Landry J, Sharov AA, Piao Y, Sharova LV, Xiao H, Southon E, Matta J, Tessarollo L, Zhang YE, Ko MS, Kuehn MR, Yamaguchi TP, Wu C
PLoS Genet. 2008
PubMed ID: 18974875
Methionine-dependence phenotype in the de novo pathway in BRCA1 and BRCA2 mutation carriers with and without breast cancer.
Beetstra S, Suthers G, Dhillon V, Salisbury C, Turner J, Altree M, McKinnon R, Fenech M
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18842997
Hormone therapy and the risk of breast cancer in BRCA1 mutation carriers.
Eisen A, Lubinski J, Gronwald J, Moller P, Lynch HT, Klijn J, Kim-Sing C, Neuhausen SL, Gilbert L, Ghadirian P, Manoukian S, Rennert G, Friedman E, Isaacs C, Rosen E, Rosen B, Daly M, Sun P, Narod SA, Hereditary Breast Cancer Clinical Study Group
J Natl Cancer Inst. 2008
PubMed ID: 18812548
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Germline BRCA1 mutations predispose to pancreatic adenocarcinoma.
Al-Sukhni W, Rothenmund H, Borgida AE, Zogopoulos G, O'Shea AM, Pollett A, Gallinger S
Hum Genet. 2008
PubMed ID: 18762988
Interaction of p14ARF with Brca1 in cancer cell lines and primary breast cancer.
He L, Fan C, Ning X, Feng X, Liu Y, Chen B, Tang D
Cell Biol Int. 2008
PubMed ID: 18703154
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
BRCA1 is required for meiotic spindle assembly and spindle assembly checkpoint activation in mouse oocytes.
Xiong B, Li S, Ai JS, Yin S, Ouyang YC, Sun SC, Chen DY, Sun QY
Biol Reprod. 2008
PubMed ID: 18596218
Pregnancy after in vitro fertilization-intracytoplasmic sperm injection obtained with a modified natural cycle in a BRCA1 mutation carrier.
Hirt R, Davy C, Guibert J, Olivennes F
Fertil Steril. 2008
PubMed ID: 18155199
High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer.
van der Groep P, Bouter A, Menko FH, van der Wall E, van Diest PJ
Breast Cancer Res Treat. 2008
PubMed ID: 18030615
BRCA1/BRCA2 mutation status and clinical-pathologic features of 108 male breast cancer cases from Tuscany: a population-based study in central Italy.
Ottini L, Rizzolo P, Zanna I, Falchetti M, Masala G, Ceccarelli K, Vezzosi V, Gulino A, Giannini G, Bianchi S, Sera F, Palli D
Breast Cancer Res Treat. 2008
PubMed ID: 18819001
Molecular and in silico analysis of BRCA1 and BRCA2 variants.
Tommasi S, Pilato B, Pinto R, Monaco A, Bruno M, Campana M, Digennaro M, Schittulli F, Lacalamita R, Paradiso A
Mutat Res. 2008
PubMed ID: 18694767
Performance of BRCA1/2 Mutation Prediction Models in Asian Americans.
Kurian AW, Gong GD, Chun NM, Mills MA, Staton AD, Kingham KE, Crawford BB, Lee R, Chan S, Donlon SS, Ridge Y, Panabaker K, West DW, Whittemore AS, Ford JM
J Clin Oncol. 2008
PubMed ID: 18779604
Evaluating the performance of models for predicting the BRCA germline mutations in Han Chinese familial breast cancer patients.
Rao NY, Hu Z, Yu JM, Li WF, Zhang B, Su FX, Wu J, Shen ZZ, Huang W, Shao ZM
Breast Cancer Res Treat. 2008
PubMed ID: 18807178
PIK3CA Mutations and BRCA1 Expression in Breast Cancer: Potential Biomarkers for Chemoresistance.
Santarpia M, Altavilla G, Margeli M, Cirauqui B, Mesiti M, Cavallari V, Ramirez JL, Sanchez-Ronco M, Santarpia L, Taron M, Rosell R
Cancer Invest. 2008
PubMed ID: 18798071
Kinetic analysis of interaction of BRCA1 tandem breast cancer c-terminal domains with phosphorylated peptides reveals two binding conformations.
Nominé Y, Botuyan MV, Bajzer Z, Owen WG, Caride AJ, Wasielewski E, Mer G
Biochemistry. 2008
PubMed ID: 18717574
Impaired tamoxifen metabolism reduces survival in familial breast cancer patients.
Newman WG, Hadfield KD, Latif A, Roberts SA, Shenton A, McHague C, Lalloo F, Howell S, Evans DG
Clin Cancer Res. 2008
PubMed ID: 18794105
Clinical and pathologic characteristics of patients with BRCA-positive and BRCA-negative breast cancer.
Atchley DP, Albarracin CT, Lopez A, Valero V, Amos CI, Gonzalez-Angulo AM, Hortobagyi GN, Arun BK
J Clin Oncol. 2008
PubMed ID: 18779615
[BRCA1/2 gene mutation in Chinese familial breast cancer patients: a multi-center report of 115 cases]
Hu Z, Li WF, Liu XY, Zhang B, Cao MZ, Wang YS, Zhao L, Song CG, Lu JS, Wu J, DI GH, Shen KW, Han QX, Shen ZZ, Huang W, Shao ZM
Zhonghua Yi Xue Za Zhi. 2008
PubMed ID: 19087709
Functional polymorphisms in the promoter of BRCA1 influences transcription and are associated with decreased risk for breast cancer in Chinese women.
Chan KY, Liu W, Long JR, Yip SP, Chan SY, Shu XO, Chua DT, Cheung AN, Ching JC, Cai H, Au GK, Chan M, Foo W, Ngan HY, Gao YT, Ngan ES, Garcia-Barcelo MM, Zheng W, Khoo US
J Med Genet. 2008
PubMed ID: 18782836
Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I.
Sordet O, Larochelle S, Nicolas E, Stevens EV, Zhang C, Shokat KM, Fisher RP, Pommier Y
J Mol Biol. 2008
PubMed ID: 18588899
Novel and common BRCA1 mutations in familial breast/ovarian cancer patients from Lithuania.
Janavičius R, Pepalytė I, Kučinskas V
Breast Cancer Res Treat. 2008
PubMed ID: 18763032
Pleomorphic adenoma of salivary glands does not appear to be a BRCA-1-dependent tumour in a Polish cohort.
Lubiński J, Tarnowska C, Jaworowska E, Byrski T, Jakubowska A, Górski B, Bień S, Sygut J, Góźdź S, Siołek M, Sulikowski M, Lubiński J
Anticancer Res. 2008
PubMed ID: 19031948
BRCA1/2 in high-risk African American women with breast cancer: providing genetic testing through various recruitment strategies.
Pal T, Vadaparampil S, Betts J, Miree C, Li S, Narod SA
Genet Test. 2008
PubMed ID: 18752448
The relative contribution of point mutations and genomic rearrangements in BRCA1 and BRCA2 in high-risk breast cancer families.
Palma MD, Domchek SM, Stopfer J, Erlichman J, Siegfried JD, Tigges-Cardwell J, Mason BA, Rebbeck TR, Nathanson KL
Cancer Res. 2008
PubMed ID: 18703817
BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway: analyses using a breast cancer cell line and tumoral xenograft model.
Yu X, Luo Y, Zhou Y, Zhang Q, Wang J, Wei N, Mi M, Zhu J, Wang B, Chang H, Tang Y
Int J Oncol. 2008
PubMed ID: 18695886
BRCA1 185delAG truncation protein, BRAt, amplifies caspase-mediated apoptosis in ovarian cells.
O'Donnell JD, Johnson NC, Turbeville TD, Alfonso MY, Kruk PA
In Vitro Cell Dev Biol Anim. 2008
PubMed ID: 18594935
BRCA1 modulates sensitivity to 5F-203 by regulating xenobiotic stress-inducible protein levels and EROD activity.
Kang HJ, Kim HJ, Kwon SH, Kang BD, Eling TE, Lee SH, Bae I
Cancer Chemother Pharmacol. 2008
PubMed ID: 18074135
Possible association between BRCA-1 carriers and incidence of uterine papillary serous carcinoma (UPSC).
Lavie O, Ben-Arie A, Gemer O
Int J Gynecol Cancer. 2008
PubMed ID: 17986237
Estrogen receptor alpha, BRCA1, and FANCF promoter methylation occur in distinct subsets of sporadic breast cancers.
Wei M, Xu J, Dignam J, Nanda R, Sveen L, Fackenthal J, Grushko TA, Olopade OI
Breast Cancer Res Treat. 2008
PubMed ID: 17932744
Use of total abdominal hysterectomy and hormone replacement therapy in BRCA1 and BRCA2 mutation carriers undergoing risk-reducing salpingo-oophorectomy.
Gabriel CA, Tigges-Cardwell J, Stopfer J, Erlichman J, Nathanson K, Domchek SM
Fam Cancer. 2008
PubMed ID: 18758995
Discovering interactions among BRCA1 and other candidate genes associated with sporadic breast cancer.
Lo SH, Chernoff H, Cong L, Ding Y, Zheng T
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18711133
Evidence for an ancient BRCA1 mutation in breast cancer patients of yoruban ancestry.
Zhang B, Fackenthal JD, Niu Q, Huo D, Sveen WE, Demarco T, Adebamowo CA, Ogundiran T, Olopade OI
Fam Cancer. 2008
PubMed ID: 18679828
Absence of founder BRCA1 and BRCA2 mutations in coetaneous malignant melanoma patients of Ashkenazi origin.
Kadouri L, Temper M, Grenader T, Abeliovich D, Hamburger T, Peretz T, Lotem M
Fam Cancer. 2008
PubMed ID: 18679827
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Uptake of testing for BRCA1/2 mutations in South East Scotland.
Holloway SM, Bernhard B, Campbell H, Lam WW
Eur J Hum Genet. 2008
PubMed ID: 18285832
Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation.
Mahadevaiah SK, Bourc'his D, de Rooij DG, Bestor TH, Turner JM, Burgoyne PS
J Cell Biol. 2008
PubMed ID: 18663141
Rapid progression of prostate cancer in men with a BRCA2 mutation.
Narod SA, Neuhausen S, Vichodez G, Armel S, Lynch HT, Ghadirian P, Cummings S, Olopade O, Stoppa-Lyonnet D, Couch F, Wagner T, Warner E, Foulkes WD, Saal H, Weitzel J, Tulman A, Poll A, Nam R, Sun P, Hereditary Breast Cancer Study Group, Danquah J, Domchek S, Tung N, Ainsworth P, Horsman D, Kim-Sing C, Maugard C, Eisen A, Daly M, McKinnon W, Wood M, Isaacs C, Gilchrist D, Karlan B, Nedelcu R, Meschino W, Garber J, Pasini B, Manoukian S, Bellati C
Br J Cancer. 2008
PubMed ID: 18577985
Evaluation of BRCA1 and BRCA2 mutations and risk-prediction models in a typical Asian country (Malaysia) with a relatively low incidence of breast cancer.
Thirthagiri E, Lee S, Kang P, Lee D, Toh G, Selamat S, Yoon SY, Taib NM, Thong M, Yip C, Teo S
Breast Cancer Res. 2008
PubMed ID: 18627636
BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways.
Kranz D, Dohmesen C, Dobbelstein M
J Cell Biol. 2008
PubMed ID: 18625847
Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1.
Yan Y, Black CP, Cao PT, Haferbier JL, Kolb RH, Spieker RS, Ristow AM, Cowan KH
Cancer Res. 2008
PubMed ID: 18593910
Founder effect of the BRCA1 5382insC mutation in Brazilian patients with hereditary breast ovary cancer syndrome.
da Costa EC, Vargas FR, Moreira AS, Lourenço JJ, Caleffi M, Ashton-Prolla P, Martins Moreira MA
Cancer Genet Cytogenet. 2008
PubMed ID: 18558292
Use of a BRCA1 peptide validates MS110 as a BRCA1-specific antibody in immunohistochemistry.
Alamshah A, Springall R, Gillett CE, Solomon E, Morris JR
Histopathology. 2008
PubMed ID: 18462360
Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach.
Tischkowitz M, Hamel N, Carvalho MA, Birrane G, Soni A, van Beers EH, Joosse SA, Wong N, Novak D, Quenneville LA, Grist SA, kConFab, Nederlof PM, Goldgar DE, Tavtigian SV, Monteiro AN, Ladias JA, Foulkes WD
Eur J Hum Genet. 2008
PubMed ID: 18285836
G1738R is a BRCA1 founder mutation in Greek breast/ovarian cancer patients: evaluation of its pathogenicity and inferences on its genealogical history.
Anagnostopoulos T, Pertesi M, Konstantopoulou I, Armaou S, Kamakari S, Nasioulas G, Athanasiou A, Dobrovic A, Young MA, Goldgar D, Fountzilas G, Yannoukakos D
Breast Cancer Res Treat. 2008
PubMed ID: 17902052
The prevalence of BRCA1 and BRCA2 germline mutations in high-risk breast cancer patients of Chinese Han nationality: two recurrent mutations were identified.
Li WF, Hu Z, Rao NY, Song CG, Zhang B, Cao MZ, Su FX, Wang YS, He PQ, Di GH, Shen KW, Wu J, Lu JS, Luo JM, Liu XY, Zhou J, Wang L, Zhao L, Liu YB, Yuan WT, Yang L, Shen ZZ, Huang W, Shao ZM
Breast Cancer Res Treat. 2008
PubMed ID: 17851763
BRCA1/BRCA2 rearrangements and CHEK2 common mutations are infrequent in Italian male breast cancer cases.
Falchetti M, Lupi R, Rizzolo P, Ceccarelli K, Zanna I, Calò V, Tommasi S, Masala G, Paradiso A, Gulino A, Giannini G, Russo A, Palli D, Ottini L
Breast Cancer Res Treat. 2008
PubMed ID: 17661168
Clinical significance of promoter hypermethylation of RASSF1A, RARbeta2, BRCA1 and HOXA5 in breast cancers of Indian patients.
Bagadi SA, Prasad CP, Kaur J, Srivastava A, Prashad R, Gupta SD, Ralhan R
Life Sci. 2008
PubMed ID: 18538349
BRCA1 and BRCA2 mutation prevalence and clinical characteristics of a population-based series of ovarian cancer cases from Denmark.
Soegaard M, Kjaer SK, Cox M, Wozniak E, Høgdall E, Høgdall C, Blaakaer J, Jacobs IJ, Gayther SA, Ramus SJ
Clin Cancer Res. 2008
PubMed ID: 18559594
No evidence that CDKN1B (p27) polymorphisms modify breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Spurdle AB, Deans AJ, Duffy D, Goldgar DE, Chen X, Beesley J, kConFaB, Easton DF, Antoniou AC, Peock S, Cook M, EMBRACE Study Collaborators, Nathanson KL, Domchek SM, Macarthur GA, Chenevix-Trench G
Breast Cancer Res Treat. 2008
PubMed ID: 18543099
High-resolution melting analysis for rapid screening of BRCA1 and BRCA2 Spanish mutations.
de Juan I, Esteban E, Palanca S, Barragán E, Bolufer P
Breast Cancer Res Treat. 2008
PubMed ID: 18528753
No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study.
Rebbeck TR, Antoniou AC, Llopis TC, Nevanlinna H, Aittomäki K, Simard J, Spurdle AB, KConFab, Couch FJ, Pereira LH, Greene MH, Andrulis IL, Ontario Cancer Genetics Network, Pasche B, Kaklamani V, Breast Cancer Family Registry, Hamann U, Szabo C, Peock S, Cook M, Harrington PA, Donaldson A, Male AM, Gardiner CA, Gregory H, Side LE, Robinson AC, Emmerson L, Ellis I, EMBRACE, Peyrat JP, Fournier J, Vennin P, Adenis C, Muller D, Fricker JP, Longy M, Sinilnikova OM, Stoppa-Lyonnet D, GEMO, Schmutzler RK, Versmold B, Engel C, Meindl A, Kast K, Schaefer D, Froster UG, Chenevix-Trench G, Easton DF
Breast Cancer Res Treat. 2008
PubMed ID: 18523885
Better life expectancy in women with BRCA2 compared with BRCA1 mutations is attributable to lower frequency and later onset of ovarian cancer.
Byrd LM, Shenton A, Maher ER, Woodward E, Belk R, Lim C, Lalloo F, Howell A, Jayson GC, Evans GD
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18559571
Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests.
Chang JS, Yeh RF, Wiencke JK, Wiemels JL, Smirnov I, Pico AR, Tihan T, Patoka J, Miike R, Sison JD, Rice T, Wrensch MR
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18559551
Predominant Ashkenazi BRCA1/2 Mutations in Families with Pancreatic Cancer.
Dagan E
Genet Test. 2008
PubMed ID: 18439109
Expression of BRCA1 protein in breast cancer and its prognostic significance.
Rakha EA, El-Sheikh SE, Kandil MA, El-Sayed ME, Green AR, Ellis IO
Hum Pathol. 2008
PubMed ID: 18400253
Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant.
Goina E, Skoko N, Pagani F
Mol Cell Biol. 2008
PubMed ID: 18391021
Power spectral analysis of mammographic parenchymal patterns for breast cancer risk assessment.
Li H, Giger ML, Olopade OI, Chinander MR
J Digit Imaging. 2008
PubMed ID: 18175183
Identification of rare complete BRCA1 gene deletion using a combination of SNP haplotype analysis, MLPA and array-CGH techniques.
Konecny M, Zavodna K, Vranova V, Vizvaryova M, Weismanova E, Mlkva I, Kuglik P, Kausitz J, Bartosova Z
Breast Cancer Res Treat. 2008
PubMed ID: 17661172
Penetrance estimates for BRCA1 and BRCA2 based on genetic testing in a Clinical Cancer Genetics service setting: risks of breast/ovarian cancer quoted should reflect the cancer burden in the family.
Evans DG, Shenton A, Woodward E, Lalloo F, Howell A, Maher ER
BMC Cancer. 2008
PubMed ID: 18513387
BRCA1 germline mutations and tumor characteristics in Chinese women with familial or early-onset breast cancer.
Chen W, Pan K, Ouyang T, Li J, Wang T, Fan Z, Fan T, Lin B, Lu Y, You W, Xie Y
Breast Cancer Res Treat. 2008
PubMed ID: 18512148
BRCA1 regulates caveolin-1 expression and inhibits cell invasiveness.
Wang Y, Yu J, Zhan Q
Biochem Biophys Res Commun. 2008
PubMed ID: 18343216
Infertility, treatment of infertility, and the risk of breast cancer among women with BRCA1 and BRCA2 mutations: a case-control study.
Kotsopoulos J, Librach CL, Lubinski J, Gronwald J, Kim-Sing C, Ghadirian P, Lynch HT, Moller P, Foulkes WD, Randall S, Manoukian S, Pasini B, Tung N, Ainsworth PJ, Cummings S, Sun P, Narod SA, Hereditary Breast Cancer Clinical Study Group
Cancer Causes Control. 2008
PubMed ID: 18509731
Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1.
Shen Y, Tong L
Biochemistry. 2008
PubMed ID: 18452305
Smoking and the risk of breast cancer in BRCA1 and BRCA2 carriers: an update.
Ginsburg O, Ghadirian P, Lubinski J, Cybulski C, Lynch H, Neuhausen S, Kim-Sing C, Robson M, Domchek S, Isaacs C, Klijn J, Armel S, Foulkes WD, Tung N, Moller P, Sun P, Narod SA, Hereditary Breast Cancer Clinical Study Group
Breast Cancer Res Treat. 2008
PubMed ID: 18483851
Higher occurrence of childhood cancer in families with germline mutations in BRCA2, MMR and CDKN2A genes.
Magnusson S, Borg A, Kristoffersson U, Nilbert M, Wiebe T, Olsson H
Fam Cancer. 2008
PubMed ID: 18481196
Loss of heterozygosity at the BRCA2 locus detected by multiplex ligation-dependent probe amplification is common in prostate cancers from men with a germline BRCA2 mutation.
Willems AJ, Dawson SJ, Samaratunga H, De Luca A, Antill YC, Hopper JL, Thorne HJ, kConFab Investigators
Clin Cancer Res. 2008
PubMed ID: 18445692
The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.
Shakya R, Szabolcs M, McCarthy E, Ospina E, Basso K, Nandula S, Murty V, Baer R, Ludwig T
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18443292
A pilot genome-wide association study of early-onset breast cancer.
Kibriya MG, Jasmine F, Argos M, Andrulis IL, John EM, Chang-Claude J, Ahsan H
Breast Cancer Res Treat. 2008
PubMed ID: 18463975
Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors.
Tapia T, Smalley SV, Kohen P, Muñoz A, Solis LM, Corvalan A, Faundez P, Devoto L, Camus M, Alvarez M, Carvallo P
Epigenetics. 2008
PubMed ID: 18567944
BRCA1 and BRCA2 missense variants of high and low clinical significance influence lymphoblastoid cell line post-irradiation gene expression.
Waddell N, Ten Haaf A, Marsh A, Johnson J, Walker LC, Investigators K, Gongora M, Brown M, Grover P, Girolami M, Grimmond S, Chenevix-Trench G, Spurdle AB
PLoS Genet. 2008
PubMed ID: 18497862
The Average Cumulative Risks of Breast and Ovarian Cancer for Carriers of Mutations in BRCA1 and BRCA2 Attending Genetic Counseling Units in Spain.
Milne RL, Osorio A, Cajal TR, Vega A, Llort G, de la Hoya M, Díez O, Alonso MC, Lazaro C, Blanco I, Sánchez-de-Abajo A, Caldés T, Blanco A, Graña B, Durán M, Velasco E, Chirivella I, Cardeñosa EE, Tejada MI, Beristain E, Miramar MD, Calvo MT, Martínez E, Guillén C, Salazar R, San Román C, Antoniou AC, Urioste M, Benítez J
Clin Cancer Res. 2008
PubMed ID: 18451254
Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.
Shafee N, Smith CR, Wei S, Kim Y, Mills GB, Hortobagyi GN, Stanbridge EJ, Lee EY
Cancer Res. 2008
PubMed ID: 18451150
Dinucleotide repeat polymorphisms of RAD51, BRCA1, BRCA2 gene regions in breast cancer.
Nowacka-Zawisza M, Brys M, Romanowicz-Makowska H, Kulig A, Krajewska WM
Pathol Int. 2008
PubMed ID: 18429825
A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations.
Folkins AK, Jarboe EA, Saleemuddin A, Lee Y, Callahan MJ, Drapkin R, Garber JE, Muto MG, Tworoger S, Crum CP
Gynecol Oncol. 2008
PubMed ID: 18342932
Nuclear export of BRCA1 occurs during early S phase and is calcium-dependent.
Glover-Collins K, Thompson ME
Cell Signal. 2008
PubMed ID: 18296025
Reconstructing the genealogy of a BRCA1 founder mutation by phylogenetic analysis.
Marroni F, Cipollini G, Peissel B, D'Andrea E, Pensabene M, Radice P, Caligo MA, Presciuttini S, Bevilacqua G
Ann Hum Genet. 2008
PubMed ID: 18215206
Allelic imbalance in BRCA1 and BRCA2 gene expression is associated with an increased breast cancer risk.
Chen X, Weaver J, Bove BA, Vanderveer LA, Weil SC, Miron A, Daly MB, Godwin AK
Hum Mol Genet. 2008
PubMed ID: 18204050
BRCA1-mediated ubiquitination inhibits topoisomerase II alpha activity in response to oxidative stress.
Shinagawa H, Miki Y, Yoshida K
Antioxid Redox Signal. 2008
PubMed ID: 18162055
Smoking and risk of breast cancer in carriers of mutations in BRCA1 or BRCA2 aged less than 50 years.
Breast Cancer Family Registry, Kathleen Cuningham Consortium for Research into Familial Breast Cancer (Australasia), Ontario Cancer Genetics Network (Canada)
Breast Cancer Res Treat. 2008
PubMed ID: 17972172
Prolonged survival among women with BRCA germline mutations and advanced endometrial cancer: a case series.
Kwon JS, Lenehan J, Carey M, Ainsworth P
Int J Gynecol Cancer. 2008
PubMed ID: 17645508
MLPA screening in the BRCA1 gene from 1,506 German hereditary breast cancer cases: novel deletions, frequent involvement of exon 17, and occurrence in single early-onset cases.
Engert S, Wappenschmidt B, Betz B, Kast K, Kutsche M, Hellebrand H, Goecke TO, Kiechle M, Niederacher D, Schmutzler RK, Meindl A
Hum Mutat. 2008
PubMed ID: 18431737
Histopathological findings and follow-up after prophylactic mastectomy and immediate breast reconstruction in 100 women from families with hereditary breast cancer.
Isern AE, Loman N, Malina J, Olsson H, Ringberg A
Eur J Surg Oncol. 2008
PubMed ID: 18434071
Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology.
Lubiński J, Korzeń M, Górski B, Cybulski C, Dębniak T, Jakubowska A, Jaworska K, Wokołorczyk D, Mędrek K, Matyjasik J, Huzarski T, Byrski T, Gronwald J, Masojć B, Lener M, Szymańska A, Szymańska-Pasternak J, Serrano-Fernàndez P, Piegat A, Uciński R, Domagała P, Domagała W, Chosia M, Kładny J, Górecka B, Narod S, Scott R
Breast Cancer Res Treat. 2008
PubMed ID: 18415014
Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance.
Swisher EM, Sakai W, Karlan BY, Wurz K, Urban N, Taniguchi T
Cancer Res. 2008
PubMed ID: 18413725
Screening for Familial Ovarian Cancer: Poor survival of BRCA1/2 related cancers.
Evans GR, Gaarenstroom KN, Stirling D, Shenton A, Maehle L, Dørum A, Steel M, Lalloo F, Apold J, Porteous M, Vasen HF, van Asperen C, Moller P
J Med Genet. 2008
PubMed ID: 18413372
On the dynamics of breast tumor development in women carrying germline BRCA1 and BRCA2 mutations.
Simon R, Zhang X
Int J Cancer. 2008
PubMed ID: 18098285
Clinical classification of BRCA1 and BRCA2 DNA sequence variants: the value of cytokeratin profiles and evolutionary analysis--a report from the kConFab Investigators.
Spurdle AB, Lakhani SR, Healey S, Parry S, Da Silva LM, Brinkworth R, Hopper JL, Brown MA, Babikyan D, Chenevix-Trench G, Tavtigian SV, Goldgar DE, kConFab Investigators
J Clin Oncol. 2008
PubMed ID: 18375895
Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene.
Tan-Wong SM, French JD, Proudfoot NJ, Brown MA
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18375767
Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Antoniou AC, Spurdle AB, Sinilnikova OM, Healey S, Pooley KA, Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Hofmann W, Sutter C, Niederacher D, Deissler H, Caldes T, Kämpjärvi K, Nevanlinna H, Simard J, Beesley J, Chen X, Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Neuhausen SL, Rebbeck TR, Wagner T, Lynch HT, Isaacs C, Weitzel J, Ganz PA, Daly MB, Tomlinson G, Olopade OI, Blum JL, Couch FJ, Peterlongo P, Manoukian S, Barile M, Radice P, Szabo CI, Pereira LH, Greene MH, Rennert G, Lejbkowicz F, Barnett-Griness O, Andrulis IL, Ozcelik H, OCGN, Gerdes AM, Caligo MA, Laitman Y, Kaufman B, Milgrom R, Friedman E, Swedish BRCA1 and BRCA2 study collaborators, Domchek SM, Nathanson KL, Osorio A, Llort G, Milne RL, Benítez J, Hamann U, Hogervorst FB, Manders P, Ligtenberg MJ, van den Ouweland AM, DNA-HEBON collaborators, Peock S, Cook M, Platte R, Evans DG, Eeles R, Pichert G, Chu C, Eccles D, Davidson R, Douglas F, EMBRACE, Godwin AK, Barjhoux L, Mazoyer S, Sobol H, Bourdon V, Eisinger F, Chompret A, Capoulade C, Bressac-de Paillerets B, Lenoir GM, Gauthier-Villars M, Houdayer C, Stoppa-Lyonnet D, GEMO, Chenevix-Trench G, Easton DF, CIMBA
Am J Hum Genet. 2008
PubMed ID: 18355772
Functional interaction between FOXO3a and ATM regulates DNA damage response.
Tsai WB, Chung YM, Takahashi Y, Xu Z, Hu MC
Nat Cell Biol. 2008
PubMed ID: 18344987
Pliocene colonization and adaptive radiations in Australia and New Guinea (Sahul): multilocus systematics of the old endemic rodents (Muroidea: Murinae).
Rowe KC, Reno ML, Richmond DM, Adkins RM, Steppan SJ
Mol Phylogenet Evol. 2008
PubMed ID: 18313945
Probability of BRCA1/2 mutation varies with ovarian histology: results from screening 442 ovarian cancer families.
Evans DG, Young K, Bulman M, Shenton A, Wallace A, Lalloo F
Clin Genet. 2008
PubMed ID: 18312450
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Asymmetric real-time PCR detection of BRCA1 5382insC mutation by melting curve analysis in the LightCycler.
Kroupis C, Christopoulos K, Devetzoglou M, Tsiagas I, Lianidou ES
Clin Chim Acta. 2008
PubMed ID: 18242166
Germline TP53 mutations in BRCA1 and BRCA2 mutation-negative French Canadian breast cancer families.
Arcand SL, Maugard CM, Ghadirian P, Robidoux A, Perret C, Zhang P, Fafard E, Mes-Masson AM, Foulkes WD, Provencher D, Narod SA, Tonin PN
Breast Cancer Res Treat. 2008
PubMed ID: 17541742
MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene.
Molli PR, Singh RR, Lee SW, Kumar R
Oncogene. 2008
PubMed ID: 17922032
Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.
Chen L, Nievera CJ, Lee AY, Wu X
J Biol Chem. 2008
PubMed ID: 18171670
Disease family history and modification of breast cancer risk in common BRCA2 variants.
Seymour IJ, Casadei S, Zampiga V, Rosato S, Danesi R, Falcini F, Strada M, Morini N, Naldoni C, Paradiso A, Tommasi S, Schittulli F, Amadori D, Calistri D
Oncol Rep. 2008
PubMed ID: 18288416
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR
J Proteome Res. 2008
PubMed ID: 18220336
Similar prevalence of founder BRCA1 and BRCA2 mutations among Ashkenazi and non-Ashkenazi men with breast cancer: evidence from 261 cases in Israel, 1976-1999.
Chodick G, Struewing JP, Ron E, Rutter JL, Iscovich J
Eur J Med Genet. 2008
PubMed ID: 18158280
Response to neo-adjuvant chemotherapy in women with BRCA1-positive breast cancers.
Byrski T, Gronwald J, Huzarski T, Grzybowska E, Budryk M, Stawicka M, Mierzwa T, Szwiec M, Wiśniowski R, Siolek M, Narod SA, Lubinski J, Polish Hereditary Breast Cancer Consortium
Breast Cancer Res Treat. 2008
PubMed ID: 17492376
Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Cuba.
Rodriguez RC, Esperon AA, Ropero R, Rubio MC, Rodriguez R, Ortiz RM, Anta JJ, de Los Rios M, Carnesolta D, Del Olivera MC, Vansam SS, Royer R, Akbari MR, Donenberg T, Narod SA
Fam Cancer. 2008
PubMed ID: 18286383
Should genetic testing for BRCA1/2 be permitted for minors? Opinions of BRCA mutation carriers and their adult offspring.
Bradbury AR, Patrick-Miller L, Pawlowski K, Ibe CN, Cummings SA, Olopade OI, Daugherty CK
Am J Med Genet C Semin Med Genet. 2008
PubMed ID: 18200524
[BRCA1 and BRCA2 mutations in families studied in the program of genetic counselling in cancer of the Valencian community (Spain)]
Esteban Cardeñosa E, Bolufer Gilabert P, Palanca Suela S, Barragán González E, Oltra Soler S, Chirivella González I, Segura Huerta A, Guillén Ponce C, Martínez de Dueñas E, Cuevas Cuerda D, Salas Trejo D, Grupo de Asesoramiento en Cáncer Hereditario de la Comunidad Valenciana
Med Clin (Barc). 2008
PubMed ID: 18279628
EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange.
Subbaramaiah K, Hudis C, Chang SH, Hla T, Dannenberg AJ
J Biol Chem. 2008
PubMed ID: 18083712
BRCA1 regulates human mammary stem/progenitor cell fate.
Liu S, Ginestier C, Charafe-Jauffret E, Foco H, Kleer CG, Merajver SD, Dontu G, Wicha MS
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18230721
[Influence of mifepristone on DNA repair genes and cisplatin sensitivity in human ovarian cancer drug-resistance cells].
Liu GY, Qu QX, Mi RR, Qi J
Zhonghua Fu Chan Ke Za Zhi. 2008
PubMed ID: 18683754
The Fanconi anaemia/BRCA pathway and cancer susceptibility. Searching for new therapeutic targets.
García MJ, Benítez J
Clin Transl Oncol. 2008
PubMed ID: 18258506
BRCA1/2 associated hereditary breast cancer.
Teng LS, Zheng Y, Wang HH
J Zhejiang Univ Sci B. 2008
PubMed ID: 18257128
Promotion of BRCA1-associated triple-negative breast cancer by ovarian hormones.
Lee EY
Curr Opin Obstet Gynecol. 2008
PubMed ID: 18197009
CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls.
Weischer M, Bojesen SE, Ellervik C, Tybjaerg-Hansen A, Nordestgaard BG
J Clin Oncol. 2008
PubMed ID: 18172190
BRCA1 mutations and prostate cancer in Poland.
Cybulski C, Górski B, Gronwald J, Huzarski T, Byrski T, Debniak T, Jakubowska A, Wokołorczyk D, Gliniewicz B, Sikorski A, Stawicka M, Godlewski D, Kwias Z, Antczak A, Krajka K, Lauer W, Sosnowski M, Sikorska-Radek P, Bar K, Klijer R, Romuald Z, Małkiewicz B, Borkowski A, Borkowski T, Szwiec M, Posmyk M, Narod SA, Lubiński J
Eur J Cancer Prev. 2008
PubMed ID: 18090912
Caspase-dependent BRCA1 cleavage facilitates chemotherapy-induced apoptosis.
Dizin E, Ray H, Suau F, Voeltzel T, Dalla Venezia N
Apoptosis. 2008
PubMed ID: 18071904
Brca1 in immunoglobulin gene conversion and somatic hypermutation.
Longerich S, Orelli BJ, Martin RW, Bishop DK, Storb U
DNA Repair (Amst). 2008
PubMed ID: 18036997
High frequency of BRCA1/2 germline mutations in consecutive ovarian cancer patients in Poland.
Brozek I, Ochman K, Debniak J, Morzuch L, Ratajska M, Stepnowska M, Stukan M, Emerich J, Limon J
Gynecol Oncol. 2008
PubMed ID: 17997147
Greek BRCA1 and BRCA2 mutation spectrum: two BRCA1 mutations account for half the carriers found among high-risk breast/ovarian cancer patients.
Konstantopoulou I, Rampias T, Ladopoulou A, Koutsodontis G, Armaou S, Anagnostopoulos T, Nikolopoulos G, Kamakari S, Nounesis G, Stylianakis A, Karanikiotis C, Razis E, Gogas H, Keramopoulos A, Gaki V, Markopoulos C, Skarlos D, Pandis N, Bei T, Arzimanoglou I, Fountzilas G, Yannoukakos D
Breast Cancer Res Treat. 2008
PubMed ID: 17453335
Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERalpha-negative and ERalpha-positive mammary preneoplasia and cancer.
Jones LP, Tilli MT, Assefnia S, Torre K, Halama ED, Parrish A, Rosen EM, Furth PA
Oncogene. 2008
PubMed ID: 17653086
Prostate cancer in male BRCA1 and BRCA2 mutation carriers has a more aggressive phenotype.
Mitra A, Fisher C, Foster CS, Jameson C, Barbachanno Y, Bartlett J, Bancroft E, Doherty R, Kote-Jarai Z, Peock S, Easton D, IMPACT and EMBRACE Collaborators, Eeles R
Br J Cancer. 2008
PubMed ID: 18182994
Early radiation exposures and BRCA1-associated breast cancer in young women from Poland.
Gronwald J, Pijpe A, Byrski T, Huzarski T, Stawicka M, Cybulski C, van Leeuwen F, Lubiński J, Narod SA
Breast Cancer Res Treat. 2008
PubMed ID: 18205043
Variation of breast cancer risk among BRCA1/2 carriers.
Begg CB, Haile RW, Borg A, Malone KE, Concannon P, Thomas DC, Langholz B, Bernstein L, Olsen JH, Lynch CF, Anton-Culver H, Capanu M, Liang X, Hummer AJ, Sima C, Bernstein JL
JAMA. 2008
PubMed ID: 18182601
Genetic analysis of BRCA1 and BRCA2 in breast/ovarian cancer families from Aragon (Spain): two novel truncating mutations and a large genomic deletion in BRCA1.
Miramar MD, Calvo MT, Rodriguez A, Antón A, Lorente F, Barrio E, Herrero A, Burriel J, García de Jalón A
Breast Cancer Res Treat. 2008
PubMed ID: 18176857
The CHEK2 1100delC mutation is not present in Korean patients with breast cancer cases tested for BRCA1 and BRCA2 mutation.
Choi DH, Cho DY, Lee MH, Park HS, Ahn SH, Son BH, Haffty BG
Breast Cancer Res Treat. 2008
PubMed ID: 18175216
[Evaluation of stomatognathic system in BRCA1 gene mutation carriers before and after prophylactic adnexectomy--part II: evaluation of stomatognathic system in BRCA1 gene mutation carriers after prophylactic adnexectomy]
Chruściel-Nogalska M
Ann Acad Med Stetin. 2008
PubMed ID: 19374245
[Evaluation of stomatognathic system in BRCA1 gene mutation carriers before and after prophylactic adnexectomy--part I: evaluation of stomatognathic system in youth BRCA1 gene mutation carriers]
Chruściel-Nogalska M
Ann Acad Med Stetin. 2008
PubMed ID: 19374244
BRCA1 knock-down causes telomere dysfunction in mammary epithelial cells.
Cabuy E, Newton C, Slijepcevic P
Cytogenet Genome Res. 2008
PubMed ID: 19188703
The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.
Tapper W, Hammond V, Gerty S, Ennis S, Simmonds P, Collins A, Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) Steering Group, Eccles D
Breast Cancer Res. 2008
PubMed ID: 19094228
Understanding genetic analysis for breast cancer and its implications for plastic surgery.
Soltanian H, Okada H
Aesthet Surg J. 2008
PubMed ID: 19083511
Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients.
Boukovinas I, Papadaki C, Mendez P, Taron M, Mavroudis D, Koutsopoulos A, Sanchez-Ronco M, Sanchez JJ, Trypaki M, Staphopoulos E, Georgoulias V, Rosell R, Souglakos J
PLoS ONE. 2008
PubMed ID: 19002265
A PP1-binding motif present in BRCA1 plays a role in its DNA repair function.
Yu YM, Pace SM, Allen SR, Deng CX, Hsu LC
Int J Biol Sci. 2008
PubMed ID: 18953404
New sequence variants in BRCA1 and BRCA2 genes detected by high-resolution melting analysis in an elderly healthy female population in Croatia.
Cvok ML, Cretnik M, Musani V, Ozretic P, Levanat S
Clin Chem Lab Med. 2008
PubMed ID: 18844490
Five recurrent BRCA1/2 mutations are responsible for cancer predisposition in the majority of Slovenian breast cancer families.
Krajc M, Teugels E, Zgajnar J, Goelen G, Besic N, Novakovic S, Hocevar M, De Grève J
BMC Med Genet. 2008
PubMed ID: 18783588
Contribution of BRCA1 germline mutation in patients with sporadic breast cancer.
Malik FA, Ashraf S, Kayani MA, Jiang WG, Mir A, Ansar M, Baloch IA, Sadiq R
Int Semin Surg Oncol. 2008
PubMed ID: 18759965
Variation in breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Rebbeck TR, Domchek SM
Breast Cancer Res. 2008
PubMed ID: 18710587
Novel sequence variants and a high frequency of recurrent polymorphisms in BRCA1 gene in Sri Lankan breast cancer patients and at risk individuals.
De Silva W, Karunanayake EH, Tennekoon KH, Allen M, Amarasinghe I, Angunawala P, Ziard MH
BMC Cancer. 2008
PubMed ID: 18662409
BRCA1 mutations in Algerian breast cancer patients: high frequency in young, sporadic cases.
Uhrhammer N, Abdelouahab A, Lafarge L, Feillel V, Ben Dib A, Bignon YJ
Int J Med Sci. 2008
PubMed ID: 18645608
Analysis of large deletions in BRCA1, BRCA2 and PALB2 genes in Finnish breast and ovarian cancer families.
Pylkäs K, Erkko H, Nikkilä J, Sólyom S, Winqvist R
BMC Cancer. 2008
PubMed ID: 18501021
Spectrum and characterisation of BRCA1 and BRCA2 deleterious mutations in high-risk Czech patients with breast and/or ovarian cancer.
Machackova E, Foretova L, Lukesova M, Vasickova P, Navratilova M, Coene I, Pavlu H, Kosinova V, Kuklova J, Claes K
BMC Cancer. 2008
PubMed ID: 18489799
BRCA1 and BRCA2 mutations in Danish families with hereditary breast and/or ovarian cancer.
Thomassen M, Hansen TV, Borg A, Lianee HT, Wikman F, Pedersen IS, Bisgaard ML, Nielsen FC, Kruse TA, Gerdes AM
Acta Oncol. 2008
PubMed ID: 18465347
Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells.
Vassilopoulos A, Wang RH, Petrovas C, Ambrozak D, Koup R, Deng CX
Int J Biol Sci. 2008
PubMed ID: 18461147
BRCA1 and BRCA2 germline mutations in Malaysian women with early-onset breast cancer without a family history.
Toh GT, Kang P, Lee SS, Lee DS, Lee SY, Selamat S, Mohd Taib NA, Yoon SY, Yip CH, Teo SH
PLoS ONE. 2008
PubMed ID: 18431501
Expression of estrogen receptor beta in the breast carcinoma of BRCA1 mutation carriers.
Litwiniuk MM, Roznowski K, Filas V, Godlewski DD, Stawicka M, Kaleta R, Breborowicz J
BMC Cancer. 2008
PubMed ID: 18405391
Haplotype analysis of TP53 polymorphisms, Arg72Pro and Ins16, in BRCA1 and BRCA2 mutation carriers of French Canadian descent.
Cavallone L, Arcand SL, Maugard C, Ghadirian P, Mes-Masson AM, Provencher D, Tonin PN
BMC Cancer. 2008
PubMed ID: 18402691
Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism.
Jakubowska A, Gronwald J, Menkiszak J, Górski B, Huzarski T, Byrski T, Benner A, Lubiński J, Scott RJ, Hamann U
BMC Cancer. 2008
PubMed ID: 18397521
Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1.
Wright MH, Robles AI, Herschkowitz JI, Hollingshead MG, Anver MR, Perou CM, Varticovski L
Mol Cancer. 2008
PubMed ID: 18394172
Involvement of a specificity proteins-binding element in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene.
Hockings JK, Degner SC, Morgan SS, Kemp MQ, Romagnolo DF
Breast Cancer Res. 2008
PubMed ID: 18377656
Complete mutation screening and haplotype characterization of BRCA1 gene in Tunisian patients with familial breast cancer.
Troudi W, Uhrhammer N, Romdhane KB, Sibille C, Amor MB, Khodjet El Khil H, Jalabert T, Mahfoudh W, Chouchane L, Ayed FB, Bignon YJ, Elgaaied AB
Cancer Biomark. 2008
PubMed ID: 18334730
Evaluation of unclassified variants in the breast cancer susceptibility genes BRCA1 and BRCA2 using five methods: results from a population-based study of young breast cancer patients.
Lee E, McKean-Cowdin R, Ma H, Chen Z, Van Den Berg D, Henderson BE, Bernstein L, Ursin G
Breast Cancer Res. 2008
PubMed ID: 18284688
Use of association studies to define genetic modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Hughes DJ
Fam Cancer. 2008
PubMed ID: 18283561
BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype.
Snell C, Krypuy M, Wong EM, kConFab investigators, Loughrey MB, Dobrovic A
Breast Cancer Res. 2008
PubMed ID: 18269736
Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics.
Wright MH, Calcagno AM, Salcido CD, Carlson MD, Ambudkar SV, Varticovski L
Breast Cancer Res. 2008
PubMed ID: 18241344
Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities.
Press JZ, De Luca A, Boyd N, Young S, Troussard A, Ridge Y, Kaurah P, Kalloger SE, Blood KA, Smith M, Spellman PT, Wang Y, Miller DM, Horsman D, Faham M, Gilks CB, Gray J, Huntsman DG
BMC Cancer. 2008
PubMed ID: 18208621
Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.
Bennett CB, Westmoreland TJ, Verrier CS, Blanchette CA, Sabin TL, Phatnani HP, Mishina YV, Huper G, Selim AL, Madison ER, Bailey DD, Falae AI, Galli A, Olson JA, Greenleaf AL, Marks JR
PLoS ONE. 2008
PubMed ID: 18197258
RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers.
Gao B, Xie XJ, Huang C, Shames DS, Chen TT, Lewis CM, Bian A, Zhang B, Olopade OI, Garber JE, Euhus DM, Tomlinson GE, Minna JD
Cancer Res. 2008
PubMed ID: 18172292
BRCA1 p.Val1688del is a deleterious mutation that recurs in breast and ovarian cancer families from Northeast Italy.
Malacrida S, Agata S, Callegaro M, Casella C, Barana D, Scaini MC, Manoukian S, Oliani C, Radice P, Barile M, Menin C, D'Andrea E, Montagna M
J Clin Oncol. 2008
PubMed ID: 18165637
Effect of BRCA1/2 mutations on long-term survival of patients with invasive ovarian cancer: the national Israeli study of ovarian cancer.
Chetrit A, Hirsh-Yechezkel G, Ben-David Y, Lubin F, Friedman E, Sadetzki S
J Clin Oncol. 2008
PubMed ID: 18165636
BRCA1 and BRCA2 point mutations and large rearrangements in breast and ovarian cancer families in Northern Poland.
Ratajska M, Brozek I, Senkus-Konefka E, Jassem J, Stepnowska M, Palomba G, Pisano M, Casula M, Palmieri G, Borg A, Limon J
Oncol Rep. 2008
PubMed ID: 18097605
No association between BRCA mutations and sex ratio in offspring of Pakistani BRCA mutation carriers.
Rashid MU, Torres D, Zaidi A, Rasheed F, Sultan F, Shakoori AR, Amin A, Hamann U
Breast Cancer Res Treat. 2008
PubMed ID: 18043900
SUMO1 negatively regulates BRCA1-mediated transcription, via modulation of promoter occupancy.
Park MA, Seok YJ, Jeong G, Lee JS
Nucleic Acids Res. 2008
PubMed ID: 18025037
Polymorphisms in DNA repair genes, ionizing radiation exposure and risk of breast cancer in U.S. Radiologic technologists.
Bhatti P, Struewing JP, Alexander BH, Hauptmann M, Bowen L, Mateus-Pereira LH, Pineda MA, Simon SL, Weinstock RM, Rosenstein M, Stovall M, Preston DL, Linet MS, Doody MM, Sigurdson AJ
Int J Cancer. 2008
PubMed ID: 17764108
Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins?
Anczuków O, Ware MD, Buisson M, Zetoune AB, Stoppa-Lyonnet D, Sinilnikova OM, Mazoyer S
Hum Mutat. 2008
PubMed ID: 17694537
BRCA1/2 mutation analysis in male breast cancer families from North West England.
Evans DG, Bulman M, Young K, Howard E, Bayliss S, Wallace A, Lalloo F
Fam Cancer. 2008
PubMed ID: 17636422
Screening for ATM sequence alterations in African-American women diagnosed with breast cancer.
Hirsch AE, Atencio DP, Rosenstein BS
Breast Cancer Res Treat. 2008
PubMed ID: 17333338
Loss of expression of FANCD2 protein in sporadic and hereditary breast cancer.
van der Groep P, Hoelzel M, Buerger H, Joenje H, de Winter JP, van Diest PJ
Breast Cancer Res Treat. 2008
PubMed ID: 17333336
Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups.
John EM, Miron A, Gong G, Phipps AI, Felberg A, Li FP, West DW, Whittemore AS
JAMA. 2007
PubMed ID: 18159056
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.
Wang B, Elledge SJ
Proc Natl Acad Sci U S A. 2007
PubMed ID: 18077395
Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.
Walker LC, Waddell N, Ten Haaf A, kConFab Investigators, Grimmond S, Spurdle AB
Breast Cancer Res Treat. 2007
PubMed ID: 18095154
Results of a population-based screening for hereditary breast cancer in a region of North-Central Italy: contribution of BRCA1/2 germ-line mutations.
Seymour IJ, Casadei S, Zampiga V, Rosato S, Danesi R, Scarpi E, Falcini F, Strada M, Morini N, Naldoni C, Amadori D, Calistri D
Breast Cancer Res Treat. 2007
PubMed ID: 18092194
BRCA1 mRNA expression levels predict for overall survival in ovarian cancer after chemotherapy.
Quinn JE, James CR, Stewart GE, Mulligan JM, White P, Chang GK, Mullan PB, Johnston PG, Wilson RH, Harkin DP
Clin Cancer Res. 2007
PubMed ID: 18094425
BRCA1 mutation and young age predict fast breast cancer growth in the Dutch, United Kingdom, and Canadian magnetic resonance imaging screening trials.
Tilanus-Linthorst MM, Obdeijn IM, Hop WC, Causer PA, Leach MO, Warner E, Pointon L, Hill K, Klijn JG, Warren RM, Gilbert FJ
Clin Cancer Res. 2007
PubMed ID: 18094417
A novel set of DNA methylation markers in urine sediments for sensitive/specific detection of bladder cancer.
Yu J, Zhu T, Wang Z, Zhang H, Qian Z, Xu H, Gao B, Wang W, Gu L, Meng J, Wang J, Feng X, Li Y, Yao X, Zhu J
Clin Cancer Res. 2007
PubMed ID: 18094410
Prolactin levels, breast-feeding and milk production in a cohort of young healthy women from high-risk breast cancer families: implications for breast cancer risk.
Hietala M, Olsson H, Jernström H
Fam Cancer. 2007
PubMed ID: 18080788
Breast cancer risk among male BRCA1 and BRCA2 mutation carriers.
Tai YC, Domchek S, Parmigiani G, Chen S
J Natl Cancer Inst. 2007
PubMed ID: 18042939
BRCA1 regulates gamma-tubulin binding to centrosomes.
Sankaran S, Crone DE, Palazzo RE, Parvin JD
Cancer Biol Ther. 2007
PubMed ID: 18087219
Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation.
Sankaran S, Crone DE, Palazzo RE, Parvin JD
Cancer Res. 2007
PubMed ID: 18056443
Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations.
Hudelist G, Wagner T, Rosner M, Fink-Retter A, Gschwantler-Kaulich D, Czerwenka K, Kroiss R, Tea M, Pischinger K, Köstler WJ, Attems J, Mueller R, Blaukopf C, Kubista E, Hengstschläger M, Singer CF
Endocr Relat Cancer. 2007
PubMed ID: 18045956
Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations.
Fackenthal JD, Olopade OI
Nat Rev Cancer. 2007
PubMed ID: 18034184
RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies.
Antoniou AC, Sinilnikova OM, Simard J, Léoné M, Dumont M, Neuhausen SL, Struewing JP, Stoppa-Lyonnet D, Barjhoux L, Hughes DJ, Coupier I, Belotti M, Lasset C, Bonadona V, Bignon YJ, Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers Study (GEMO), Rebbeck TR, Wagner T, Lynch HT, Domchek SM, Nathanson KL, Garber JE, Weitzel J, Narod SA, Tomlinson G, Olopade OI, Godwin A, Isaacs C, Jakubowska A, Lubinski J, Gronwald J, Górski B, Byrski T, Huzarski T, Peock S, Cook M, Baynes C, Murray A, Rogers M, Daly PA, Dorkins H, Epidemiological Study of BRCA1 and BRCA2 Mutation Carriers (EMBRACE), Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Niederacher D, Deissler H, German Consortium for Hereditary Breast and Ovarian Cancer (GCHBOC), Spurdle AB, Chen X, Waddell N, Cloonan N, Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab), Kirchhoff T, Offit K, Friedman E, Kaufmann B, Laitman Y, Galore G, Rennert G, Lejbkowicz F, Raskin L, Andrulis IL, Ilyushik E, Ozcelik H, Devilee P, Vreeswijk MP, Greene MH, Prindiville SA, Osorio A, Benitez J, Zikan M, Szabo CI, Kilpivaara O, Nevanlinna H, Hamann U, Durocher F, Arason A, Couch FJ, Easton DF, Chenevix-Trench G, Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)
Am J Hum Genet. 2007
PubMed ID: 17999359
BRCA1 and BRCA2 germline mutation analysis in the Indonesian population.
Purnomosari D, Pals G, Wahyono A, Aryandono T, Manuaba TW, Haryono SJ, van Diest PJ
Breast Cancer Res Treat. 2007
PubMed ID: 17972177
Women with BRCA1 or BRCA2 mutations renegotiating a post-prophylactic mastectomy identity: self-image and self-disclosure.
Kenen RH, Shapiro PJ, Hantsoo L, Friedman S, Coyne JC
J Genet Couns. 2007
PubMed ID: 17917796
Contribution of BRCA1 and BRCA2 mutations to inherited ovarian cancer.
Ramus SJ, Harrington PA, Pye C, DiCioccio RA, Cox MJ, Garlinghouse-Jones K, Oakley-Girvan I, Jacobs IJ, Hardy RM, Whittemore AS, Ponder BA, Piver MS, Pharoah PD, Gayther SA
Hum Mutat. 2007
PubMed ID: 17688236
Prevalence of BRCA1 and BRCA2 genomic rearrangements in a cohort of consecutive Italian breast and/or ovarian cancer families.
Buffone A, Capalbo C, Ricevuto E, Sidoni T, Ottini L, Falchetti M, Cortesi E, Marchetti P, Scambia G, Tomao S, Rinaldi C, Zani M, Ferraro S, Frati L, Screpanti I, Gulino A, Giannini G
Breast Cancer Res Treat. 2007
PubMed ID: 17333342
Differences in the frequency and distribution of BRCA1 and BRCA2 mutations in breast/ovarian cancer cases from the Basque country with respect to the Spanish population: implications for genetic counselling.
Beristain E, Martínez-Bouzas C, Guerra I, Viguera N, Moreno J, Ibañez E, Díez J, Rodríguez F, Mallabiabarrena G, Luján S, Gorostiaga J, De Pablo JL, Mendizabal JL, Tejada MI
Breast Cancer Res Treat. 2007
PubMed ID: 17262179
Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer.
Hosey AM, Gorski JJ, Murray MM, Quinn JE, Chung WY, Stewart GE, James CR, Farragher SM, Mulligan JM, Scott AN, Dervan PA, Johnston PG, Couch FJ, Daly PA, Kay E, McCann A, Mullan PB, Harkin DP
J Natl Cancer Inst. 2007
PubMed ID: 18000219
MDM2 SNP309 accelerates breast and ovarian carcinogenesis in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent.
Yarden RI, Friedman E, Metsuyanim S, Olender T, Ben-Asher E, Papa MZ
Breast Cancer Res Treat. 2007
PubMed ID: 18026875
Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations.
Maor S, Yosepovich A, Papa MZ, Yarden RI, Mayer D, Friedman E, Werner H
Cancer Lett. 2007
PubMed ID: 17766039
Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.
Anindya R, Aygün O, Svejstrup JQ
Mol Cell. 2007
PubMed ID: 17996703
A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation.
Li W, Xiao C, Vonderhaar BK, Deng CX
Oncogene. 2007
PubMed ID: 17496925
A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes.
Easton DF, Deffenbaugh AM, Pruss D, Frye C, Wenstrup RJ, Allen-Brady K, Tavtigian SV, Monteiro AN, Iversen ES, Couch FJ, Goldgar DE
Am J Hum Genet. 2007
PubMed ID: 17924331
The impact of BRCA1 on spina bifida meningomyelocele lesions.
King TM, Au KS, Kirkpatrick TJ, Davidson C, Fletcher JM, Townsend I, Tyerman GH, Shimmin LC, Northrup H
Ann Hum Genet. 2007
PubMed ID: 17640328
Familial breast/ovarian cancer and BRCA1/2 genetic screening: the role of immunohistochemistry as an additional method in the selection of patients.
Vaz FH, Machado PM, Brandão RD, Laranjeira CT, Eugénio JS, Fernandes AH, André SP
J Histochem Cytochem. 2007
PubMed ID: 17625228
BRCA1 genetic testing in 106 breast and ovarian cancer families from Southern Italy (Sicily): a mutation analyses.
Russo A, Calò V, Agnese V, Bruno L, Corsale S, Augello C, Gargano G, Barbera F, Cascio S, Intrivici C, Rinaldi G, Gulotta G, Macaluso M, Surmacz E, Giordano A, Gebbia N, Bazan V
Breast Cancer Res Treat. 2007
PubMed ID: 17221156
Distant disease-free interval, site of first relapse and post-relapse survival in BRCA1- and BRCA2-associated compared to sporadic breast cancer patients.
Kriege M, Seynaeve C, Meijers-Heijboer H, Collee JM, Menke-Pluymers MB, Bartels CC, Tilanus-Linthorst MM, van den Ouweland A, van Geel B, Brekelmans CT, Klijn JG
Breast Cancer Res Treat. 2007
PubMed ID: 17952592
RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors.
Martin RW, Orelli BJ, Yamazoe M, Minn AJ, Takeda S, Bishop DK
Cancer Res. 2007
PubMed ID: 17942895
BRCA1 and BRCA2 genetic testing in Hispanic patients: mutation prevalence and evaluation of the BRCAPRO risk assessment model.
Vogel KJ, Atchley DP, Erlichman J, Broglio KR, Ready KJ, Valero V, Amos CI, Hortobagyi GN, Lu KH, Arun B
J Clin Oncol. 2007
PubMed ID: 17925560
[Several risk factors of breast cancer development and prognosis of its course]
Dovzhenko SP, Rassi Kh, Zakhartseva LM, Podol'skaia SV, Miasoedov DV, Gorovenko NG
Lik Sprava. 2007
PubMed ID: 18663943
[BRCA1 germ line mutations in Chinese early-onset breast cancer patients]
Li WF, Hu Z, Liu XY, Zhang B, Cao MZ, Wang YS, Zhao L, Liu YB, Yuan WT, Shen ZZ, Huang W, Shao ZM
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007
PubMed ID: 17922413
E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages.
Christensen DE, Brzovic PS, Klevit RE
Nat Struct Mol Biol. 2007
PubMed ID: 17873885
Screening for BRCA1 and BRCA2 mutations in Eastern Finnish breast/ovarian cancer families.
Hartikainen JM, Kataja V, Pirskanen M, Arffman A, Ristonmaa U, Vahteristo P, Ryynänen M, Heinonen S, Kosma VM, Mannermaa A
Clin Genet. 2007
PubMed ID: 17850627
BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL-induced apoptosis in breast cancer cells.
Fitzgerald LD, Bailey CK, Brandt SJ, Thompson ME
FEBS J. 2007
PubMed ID: 17803681
Identification and in silico analysis of functional SNPs of the BRCA1 gene.
Rajasekaran R, Sudandiradoss C, Doss CG, Sethumadhavan R
Genomics. 2007
PubMed ID: 17719744
Polymorphism in nucleotide excision repair gene XPC correlates with bleomycin-induced chromosomal aberrations.
Laczmanska I, Gil J, Karpinski P, Stembalska A, Trusewicz A, Pesz K, Ramsey D, Schlade-Bartusiak K, Blin N, Sasiadek MM
Environ Mol Mutagen. 2007
PubMed ID: 17685459
Activation of BTAK expression in primary ovarian surface epithelial cells of prophylactic ovaries.
Zhang Z, Singh M, Davidson S, Rosen DG, Yang G, Liu J
Mod Pathol. 2007
PubMed ID: 17673924
Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase.
Kumaraswamy E, Shiekhattar R
Mol Cell Biol. 2007
PubMed ID: 17664283
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.
Gupta R, Sharma S, Sommers JA, Kenny MK, Cantor SB, Brosh RM
Blood. 2007
PubMed ID: 17596542
Lymphocyte radiosensitivity in BRCA1 and BRCA2 mutation carriers and implications for breast cancer susceptibility.
Barwell J, Pangon L, Georgiou A, Kesterton I, Langman C, Arden-Jones A, Bancroft E, Salmon A, Locke I, Kote-Jarai Z, Morris JR, Solomon E, Berg J, Docherty Z, Camplejohn R, Eeles R, Hodgson SV
Int J Cancer. 2007
PubMed ID: 17582599
Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.
Jeng YM, Cai-Ng S, Li A, Furuta S, Chew H, Chen PL, Lee EY, Lee WH
Oncogene. 2007
PubMed ID: 17420720
BRCA1a has antitumor activity in TN breast, ovarian and prostate cancers.
Yuli C, Shao N, Rao R, Aysola P, Reddy V, Oprea-llies G, Lee L, Okoli J, Partridge E, Reddy ES, Rao VN
Oncogene. 2007
PubMed ID: 17384678
[Novel BRCA1 gene mutations in breast cancer patients from St. Petersburg]
Tikhomirova OS, Grudinina NA, Golubkov VI, Mandel'shtam MIu, Vasil'ev BV
Genetika. 2007
PubMed ID: 17990525
Germline BRCA1 mutation and survival analysis in familial breast cancer patients in Kerala; South India.
Vinodkumar B, Syamala V, Abraham EK, Balakrishnan R, Ankathil R
J Exp Clin Cancer Res. 2007
PubMed ID: 17987791
Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis.
Deeb KK, Michalowska AM, Yoon CY, Krummey SM, Hoenerhoff MJ, Kavanaugh C, Li MC, Demayo FJ, Linnoila I, Deng CX, Lee EY, Medina D, Shih JH, Green JE
Cancer Res. 2007
PubMed ID: 17804718
Primary fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reduction.
Callahan MJ, Crum CP, Medeiros F, Kindelberger DW, Elvin JA, Garber JE, Feltmate CM, Berkowitz RS, Muto MG
J Clin Oncol. 2007
PubMed ID: 17761984
Oral contraceptives and breast cancer risk in the international BRCA1/2 carrier cohort study: a report from EMBRACE, GENEPSO, GEO-HEBON, and the IBCCS Collaborating Group.
Brohet RM, Goldgar DE, Easton DF, Antoniou AC, Andrieu N, Chang-Claude J, Peock S, Eeles RA, Cook M, Chu C, Noguès C, Lasset C, Berthet P, Meijers-Heijboer H, Gerdes AM, Olsson H, Caldes T, van Leeuwen FE, Rookus MA
J Clin Oncol. 2007
PubMed ID: 17635951
Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage.
Au WW, Henderson BR
Cell Signal. 2007
PubMed ID: 17531442
Surveillance for familial breast cancer: Differences in outcome according to BRCA mutation status.
Moller P, Evans DG, Reis MM, Gregory H, Anderson E, Maehle L, Lalloo F, Howell A, Apold J, Clark N, Lucassen A, Steel CM
Int J Cancer. 2007
PubMed ID: 17471561
BRCA1 disease-associated haplotypes in Singapore Malay women with early-onset breast/ovarian cancer.
Ali AB, Iau PT, Putti TC, Sng JH
Breast Cancer Res Treat. 2007
PubMed ID: 17406974
Prediction of BRCA1 and BRCA2 mutation status using post-irradiation assays of lymphoblastoid cell lines is compromised by inter-cell-line phenotypic variability.
Lovelock PK, Wong EM, Sprung CN, Marsh A, Hobson K, French JD, Southey M, Sculley T, Pandeya N, Brown MA, Chenevix-Trench G, Spurdle AB, McKay MJ, kConFab Investigators
Breast Cancer Res Treat. 2007
PubMed ID: 17063265
Methylenetetrahydrofolate reductase polymorphisms modify BRCA1-associated breast and ovarian cancer risks.
Jakubowska A, Gronwald J, Menkiszak J, Górski B, Huzarski T, Byrski T, Edler L, Lubiński J, Scott RJ, Hamann U
Breast Cancer Res Treat. 2007
PubMed ID: 17063264
Compromised Fanconi anemia response due to BRCA1 deficiency in cisplatin-sensitive head and neck cancer cell lines.
Burkitt K, Ljungman M
Cancer Lett. 2007
PubMed ID: 17321670
Functional consequences of cyclin D1/BRCA1 interaction in breast cancer cells.
Kehn K, Berro R, Alhaj A, Bottazzi ME, Yeh WI, Klase Z, Van Duyne R, Fu S, Kashanchi F
Oncogene. 2007
PubMed ID: 17334399
High frequency of BRCA1/2 and p53 somatic inactivation in sporadic ovarian cancer.
Zikan M, Janatova M, Pavlista D, Pohlreich P
J Genet. 2007
PubMed ID: 17968145
[5589del8: the recurrent mutation of BRCA1 gene in Chinese breast cancer patients]
Hu Z, Li WF, Liu XY, Zhang B, Cao MZ, Wang YS, Zhao L, Song CG, Lu JS, Wu J, Di GH, Shen KW, Han QX, Shen ZZ, Huang W, Shao ZM
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007
PubMed ID: 17680524
Evidence for common ancestral origin of a recurring BRCA1 genomic rearrangement identified in high-risk Hispanic families.
Weitzel JN, Lagos VI, Herzog JS, Judkins T, Hendrickson B, Ho JS, Ricker CN, Lowstuter KJ, Blazer KR, Tomlinson G, Scholl T
Cancer Epidemiol Biomarkers Prev. 2007
PubMed ID: 17646271
CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response.
Kim H, Huang J, Chen J
Nat Struct Mol Biol. 2007
PubMed ID: 17643122
CCDC98 targets BRCA1 to DNA damage sites.
Liu Z, Wu J, Yu X
Nat Struct Mol Biol. 2007
PubMed ID: 17643121
Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activity.
Ma Y, Hu C, Riegel AT, Fan S, Rosen EM
Mol Endocrinol. 2007
PubMed ID: 17505062
AAV vector integration sites in mouse hepatocellular carcinoma.
Donsante A, Miller DG, Li Y, Vogler C, Brunt EM, Russell DW, Sands MS
Science. 2007
PubMed ID: 17656716
Regulation of BRCA1 messenger RNA stability in human epithelial cell lines and during cell cycle progression.
Saunus JM, Edwards SL, French JD, Smart CE, Brown MA
FEBS Lett. 2007
PubMed ID: 17612526
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer.
Liu X, Holstege H, van der Gulden H, Treur-Mulder M, Zevenhoven J, Velds A, Kerkhoven RM, van Vliet MH, Wessels LF, Peterse JL, Berns A, Jonkers J
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17626182
BRCA mutations in women with ductal carcinoma in situ.
Smith KL, Adank M, Kauff N, Lafaro K, Boyd J, Lee JB, Hudis C, Offit K, Robson M
Clin Cancer Res. 2007
PubMed ID: 17634561
The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.
Yan J, Kim YS, Yang XP, Li LP, Liao G, Xia F, Jetten AM
Cancer Res. 2007
PubMed ID: 17621610
Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations.
Rennert G, Bisland-Naggan S, Barnett-Griness O, Bar-Joseph N, Zhang S, Rennert HS, Narod SA
N Engl J Med. 2007
PubMed ID: 17625123
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells.
Peng M, Litman R, Xie J, Sharma S, Brosh RM, Cantor SB
EMBO J. 2007
PubMed ID: 17581638
Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients.
Mirza S, Sharma G, Prasad CP, Parshad R, Srivastava A, Gupta SD, Ralhan R
Life Sci. 2007
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High incidence of mutations in BRCA1 and BRCA2 genes in ovarian cancer.
Smirnova TY, Pospekhova NI, Lyubchenko LN, Tjulandin SA, Gar'kavtseva RF, Ginter EK, Karpukhin AV
Bull Exp Biol Med. 2007
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Immunolocalization of BRCA1 protein in tumor breast tissue: prescreening of BRCA1 mutation in Tunisian patients with hereditary breast cancer?
Troudi W, Uhrhammer N, Ben Romdhane K, Sibille C, Mahfoudh W, Chouchane L, Ben Ayed F, Bignon YJ, Ben Ammar Elgaaied A
Eur J Histochem. 2007
PubMed ID: 17921118
Attenuated DNA damage repair by trichostatin A through BRCA1 suppression.
Zhang Y, Carr T, Dimtchev A, Zaer N, Dritschilo A, Jung M
Radiat Res. 2007
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A mutation in the 5' untranslated region of the BRCA1 gene in sporadic breast cancer causes downregulation of translation efficiency.
Wang J, Lu C, Min D, Wang Z, Ma X
J Int Med Res. 2007
PubMed ID: 17697535
AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study.
Couch FJ, Sinilnikova O, Vierkant RA, Pankratz VS, Fredericksen ZS, Stoppa-Lyonnet D, Coupier I, Hughes D, Hardouin A, Berthet P, Peock S, Cook M, Baynes C, Hodgson S, Morrison PJ, Porteous ME, Jakubowska A, Lubinski J, Gronwald J, Spurdle AB, kConFab, Schmutzler R, Versmold B, Engel C, Meindl A, Sutter C, Horst J, Schaefer D, Offit K, Kirchhoff T, Andrulis IL, Ilyushik E, Glendon G, Devilee P, Vreeswijk MP, Vasen HF, Borg A, Backenhorn K, Struewing JP, Greene MH, Neuhausen SL, Rebbeck TR, Nathanson K, Domchek S, Wagner T, Garber JE, Szabo C, Zikan M, Foretova L, Olson JE, Sellers TA, Lindor N, Nevanlinna H, Tommiska J, Aittomaki K, Hamann U, Rashid MU, Torres D, Simard J, Durocher F, Guenard F, Lynch HT, Isaacs C, Weitzel J, Olopade OI, Narod S, Daly MB, Godwin AK, Tomlinson G, Easton DF, Chenevix-Trench G, Antoniou AC, Consortium of Investigators of Modifiers of BRCA1/2
Cancer Epidemiol Biomarkers Prev. 2007
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BRCA1 activates a G2-M cell cycle checkpoint following 6-thioguanine-induced DNA mismatch damage.
Yamane K, Schupp JE, Kinsella TJ
Cancer Res. 2007
PubMed ID: 17616687
Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function.
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Cancer Res. 2007
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Common variation in the BRCA1 gene and prostate cancer risk.
Douglas JA, Levin AM, Zuhlke KA, Ray AM, Johnson GR, Lange EM, Wood DP, Cooney KA
Cancer Epidemiol Biomarkers Prev. 2007
PubMed ID: 17585057
Absence of full-length Brca1 sensitizes mice to oxidative stress and carcinogen-induced tumorigenesis in the esophagus and forestomach.
Cao L, Xu X, Cao LL, Wang RH, Coumoul X, Kim SS, Deng CX
Carcinogenesis. 2007
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Cancer risks in carriers of the BRCA1/2 Ashkenazi founder mutations.
Kadouri L, Hubert A, Rotenberg Y, Hamburger T, Sagi M, Nechushtan C, Abeliovich D, Peretz T
J Med Genet. 2007
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BRCA1-IRIS activates cyclin D1 expression in breast cancer cells by downregulating the JNK phosphatase DUSP3/VHR.
Hao L, ElShamy WM
Int J Cancer. 2007
PubMed ID: 17278098
Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Brazil.
Gomes MC, Costa MM, Borojevic R, Monteiro AN, Vieira R, Koifman S, Koifman RJ, Li S, Royer R, Zhang S, Narod SA
Breast Cancer Res Treat. 2007
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The 3' untranslated region C > T polymorphism of prohibitin is a breast cancer risk modifier in Polish women carrying a BRCA1 mutation.
Jakubowska A, Gronwald J, Górski B, Huzarski T, Byrski T, Benner A, Lubiński J, Scott RJ, Hamann U
Breast Cancer Res Treat. 2007
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A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.
Mu JJ, Wang Y, Luo H, Leng M, Zhang J, Yang T, Besusso D, Jung SY, Qin J
J Biol Chem. 2007
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Large genomic rearrangement in BRCA1 and BRCA2 and clinical characteristics of men with breast cancer in the United States.
Tchou J, Ward MR, Volpe P, Palma MD, Medina CA, Sargen M, Sonnad SS, Godwin AK, Daly M, Winchester DJ, Garber J, Weber BL, Domchek S, Nathanson KL
Clin Breast Cancer. 2007
PubMed ID: 17592676
4843delC of the BRCA1 gene is a possible founder mutation in Southern Italy (Sicily).
Russo A, Calò V, Augello C, Bruno L, Agnese V, Schirò V, Barbera F, Cascio S, Foddai E, Badalamenti G, Intrivici C, Cajozzo M, Gulotta G, Surmacz E, Colucci G, Gebbia N, Bazan V
Ann Oncol. 2007
PubMed ID: 17591844
Founder mutations in BRCA1 and BRCA2 genes.
Ferla R, Calò V, Cascio S, Rinaldi G, Badalamenti G, Carreca I, Surmacz E, Colucci G, Bazan V, Russo A
Ann Oncol. 2007
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High prevalence of BRCA1 deletions in BRCAPRO-positive patients with high carrier probability.
Veschi S, Aceto G, Scioletti AP, Gatta V, Palka G, Cama A, Mariani-Costantini R, Battista P, Calò V, Barbera F, Bazan V, Russo A, Stuppia L
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[Analysis of the mutation of BRCA1 gene in 70 Uigur women breast cancer patients in Xinjiang]
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Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007
PubMed ID: 17557253
X inactive-specific transcript RNA coating and genetic instability of the X chromosome in BRCA1 breast tumors.
Vincent-Salomon A, Ganem-Elbaz C, Manié E, Raynal V, Sastre-Garau X, Stoppa-Lyonnet D, Stern MH, Heard E
Cancer Res. 2007
PubMed ID: 17545591
Thermal unfolding of human BRCA1 BRCT-domain variants.
Nikolopoulos G, Pyrpassopoulos S, Thanassoulas A, Klimentzou P, Zikos C, Vlassi M, Vorgias CE, Yannoukakos D, Nounesis G
Biochim Biophys Acta. 2007
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Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
Wu C, Ma MH, Brown KR, Geisler M, Li L, Tzeng E, Jia CY, Jurisica I, Li SS
Proteomics. 2007
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Loss of nuclear BRCA1 protein staining in normal tissue cells derived from BRCA1 and BRCA2 mutation carriers.
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Mutat Res. 2007
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BRCA mutations, molecular markers, and clinical variables in early-onset breast cancer: a population-based study.
Musolino A, Bella MA, Bortesi B, Michiara M, Naldi N, Zanelli P, Capelletti M, Pezzuolo D, Camisa R, Savi M, Neri TM, Ardizzoni A
Breast. 2007
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Integrin beta3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk.
Jakubowska A, Gronwald J, Menkiszak J, Górski B, Huzarski T, Byrski T, Edler L, Lubinski J, Scott RJ, Hamann U
J Med Genet. 2007
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High proportion of BRCA1/2 founder mutations in Hispanic breast/ovarian cancer families from Colombia.
Torres D, Rashid MU, Gil F, Umana A, Ramelli G, Robledo JF, Tawil M, Torregrosa L, Briceno I, Hamann U
Breast Cancer Res Treat. 2007
PubMed ID: 17080309
Role of single nucleotide polymorphisms and haplotypes in BRCA1 in breast cancer: Czech case-control study.
Soucek P, Borovanova T, Pohlreich P, Kleibl Z, Novotny J
Breast Cancer Res Treat. 2007
PubMed ID: 17039264
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.
Kim H, Chen J, Yu X
Science. 2007
PubMed ID: 17525342
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.
Sobhian B, Shao G, Lilli DR, Culhane AC, Moreau LA, Xia B, Livingston DM, Greenberg RA
Science. 2007
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Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.
Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ
Science. 2007
PubMed ID: 17525340
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ
Science. 2007
PubMed ID: 17525332
Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1.
Hinton CV, Fitzgerald LD, Thompson ME
Exp Cell Res. 2007
PubMed ID: 17428466
No efficacy of annual gynaecological screening in BRCA1/2 mutation carriers; an observational follow-up study.
Hermsen BB, Olivier RI, Verheijen RH, van Beurden M, de Hullu JA, Massuger LF, Burger CW, Brekelmans CT, Mourits MJ, de Bock GH, Gaarenstroom KN, van Boven HH, Mooij TM, Rookus MA
Br J Cancer. 2007
PubMed ID: 17426707
This article was published online in error and has been removed by the publisher.

Hum Mol Genet. 2007
PubMed ID: 17409195
Cancer risks for Australian women with a BRCA1 or a BRCA2 mutation.
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ANZ J Surg. 2007
PubMed ID: 17497966
Regulation of the BRCA1 promoter in ovarian surface epithelial cells and ovarian carcinoma cells.
Graves ML, Zhou L, MacDonald G, Mueller CR, Roskelley CD
FEBS Lett. 2007
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Screening for the BRCA1-ins6kbEx13 mutation: potential for misdiagnosis. Mutation in brief #964. Online.
Ramus SJ, Harrington PA, Pye C, Peock S, Cook MR, Cox MJ, Jacobs IJ, DiCioccio RA, Whittemore AS, Piver MS, EMBRACE, Easton DF, Ponder BA, Pharoah PD, Gayther SA
Hum Mutat. 2007
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Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility.
Johnson N, Fletcher O, Palles C, Rudd M, Webb E, Sellick G, dos Santos Silva I, McCormack V, Gibson L, Fraser A, Leonard A, Gilham C, Tavtigian SV, Ashworth A, Houlston R, Peto J
Hum Mol Genet. 2007
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Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality.
Wang X, Liu L, Montagna C, Ried T, Deng CX
Cell Death Differ. 2007
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Methyl group metabolism gene polymorphisms as modifier of breast cancer risk in Italian BRCA1/2 carriers.
Pepe C, Guidugli L, Sensi E, Aretini P, D'Andrea E, Montagna M, Manoukian S, Ottini L, Radice P, Viel A, Bevilacqua G, Caligo MA
Breast Cancer Res Treat. 2007
PubMed ID: 17151928
BRCA1 and TP53 mutation spectrum of breast carcinoma in an ethnic population of Kashmir, an emerging high-risk area.
Eachkoti R, Hussain I, Afroze D, Aejazaziz S, Jan M, Shah ZA, Das BC, Siddiqi MA
Cancer Lett. 2007
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A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase.
Horwitz AA, Affar el B, Heine GF, Shi Y, Parvin JD
Proc Natl Acad Sci U S A. 2007
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BRCA1 haploinsufficiency, but not heterozygosity for a BRCA1-truncating mutation, deregulates homologous recombination.
Cousineau I, Belmaaza A
Cell Cycle. 2007
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Meta-analysis of BRCA1 and BRCA2 penetrance.
Chen S, Parmigiani G
J Clin Oncol. 2007
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Estrogen receptor alpha is a putative substrate for the BRCA1 ubiquitin ligase.
Eakin CM, Maccoss MJ, Finney GL, Klevit RE
Proc Natl Acad Sci U S A. 2007
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[Study of BRCA1 and BRCA2 gene mutations in human sporadic breast cancers]
Zhang HT, Lu YF, Zeng J, Lin J, Liao QH, Wan FQ
Zhonghua Wai Ke Za Zhi. 2007
PubMed ID: 17686308
Identification of novel BRCA large genomic rearrangements in Singapore Asian breast and ovarian patients with cancer.
Lim YK, Lau PT, Ali AB, Lee SC, Wong JE, Putti TC, Sng JH
Clin Genet. 2007
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Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids.
Jourdan ML, Mahéo K, Barascu A, Goupille C, De Latour MP, Bougnoux P, Rio PG
Oncol Rep. 2007
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BRCA1 and BRCA2 status in a Central Sudanese series of breast cancer patients: interactions with genetic, ethnic and reproductive factors.
Awadelkarim KD, Aceto G, Veschi S, Elhaj A, Morgano A, Mohamedani AA, Eltayeb EA, Abuidris D, Di Gioacchino M, Battista P, Verginelli F, Cama A, Elwali NE, Mariani-Costantini R
Breast Cancer Res Treat. 2007
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CYP17 genotype is associated with short menstrual cycles, early oral contraceptive use and BRCA mutation status in young healthy women.
Henningson M, Johansson U, Borg A, Olsson H, Jernström H
Mol Hum Reprod. 2007
PubMed ID: 17307805
BRCA1 contributes to cell cycle arrest and chemoresistance in response to the anticancer agent irofulven.
Wiltshire T, Senft J, Wang Y, Konat GW, Wenger SL, Reed E, Wang W
Mol Pharmacol. 2007
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Predictive genetic testing for BRCA1/2 in a UK clinical cohort: three-year follow-up.
Foster C, Watson M, Eeles R, Eccles D, Ashley S, Davidson R, Mackay J, Morrison PJ, Hopwood P, Evans DG, Psychosocial Study Collaborators
Br J Cancer. 2007
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A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.
Zhao GY, Sonoda E, Barber LJ, Oka H, Murakawa Y, Yamada K, Ikura T, Wang X, Kobayashi M, Yamamoto K, Boulton SJ, Takeda S
Mol Cell. 2007
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Lymphoblasts of women with BRCA1 mutations are deficient in cellular repair of 8,5'-Cyclopurine-2'-deoxynucleosides and 8-hydroxy-2'-deoxyguanosine.
Rodriguez H, Jaruga P, Leber D, Nyaga SG, Evans MK, Dizdaroglu M
Biochemistry. 2007
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Prediction of BRCA1/2 mutation status in patients with ovarian cancer from a hospital-based cohort.
Jacobi CE, van Ierland Y, van Asperen CJ, Hallensleben E, Devilee P, Jan Fleuren G, Kenter GG
Genet Med. 2007
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BRCA1 regulates IFN-gamma signaling through a mechanism involving the type I IFNs.
Buckley NE, Hosey AM, Gorski JJ, Purcell JW, Mulligan JM, Harkin DP, Mullan PB
Mol Cancer Res. 2007
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Insulin-like growth factor-I controls BRCA1 gene expression through activation of transcription factor Sp1.
Maor S, Papa MZ, Yarden RI, Friedman E, Lerenthal Y, Lee SW, Mayer D, Werner H
Horm Metab Res. 2007
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A mouse model of basal-like breast carcinoma with metaplastic elements.
McCarthy A, Savage K, Gabriel A, Naceur C, Reis-Filho JS, Ashworth A
J Pathol. 2007
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Ubiquitination and proteasome-mediated degradation of BRCA1 and BARD1 during steroidogenesis in human ovarian granulosa cells.
Lu Y, Amleh A, Sun J, Jin X, McCullough SD, Baer R, Ren D, Li R, Hu Y
Mol Endocrinol. 2007
PubMed ID: 17185394
Genistein inhibits Brca1 mutant tumor growth through activation of DNA damage checkpoints, cell cycle arrest, and mitotic catastrophe.
Tominaga Y, Wang A, Wang RH, Wang X, Cao L, Deng CX
Cell Death Differ. 2007
PubMed ID: 17024228
Ductal carcinoma in situ in BRCA mutation carriers.
Hwang ES, McLennan JL, Moore DH, Crawford BB, Esserman LJ, Ziegler JL
J Clin Oncol. 2007
PubMed ID: 17210933
Determination of cancer risk associated with germ line BRCA1 missense variants by functional analysis.
Carvalho MA, Marsillac SM, Karchin R, Manoukian S, Grist S, Swaby RF, Urmenyi TP, Rondinelli E, Silva R, Gayol L, Baumbach L, Sutphen R, Pickard-Brzosowicz JL, Nathanson KL, Sali A, Goldgar D, Couch FJ, Radice P, Monteiro AN
Cancer Res. 2007
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Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.
Cannavo E, Gerrits B, Marra G, Schlapbach R, Jiricny J
J Biol Chem. 2007
PubMed ID: 17148452
The RAD51 135 G>C polymorphism modifies breast cancer and ovarian cancer risk in Polish BRCA1 mutation carriers.
Jakubowska A, Gronwald J, Menkiszak J, Górski B, Huzarski T, Byrski T, Edler L, Lubiñski J, Scott RJ, Hamann U
Cancer Epidemiol Biomarkers Prev. 2007
PubMed ID: 17301259
Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer.
Lee MN, Tseng RC, Hsu HS, Chen JY, Tzao C, Ho WL, Wang YC
Clin Cancer Res. 2007
PubMed ID: 17289874
BRCA1 ubiquitinates RPB8 in response to DNA damage.
Wu W, Nishikawa H, Hayami R, Sato K, Honda A, Aratani S, Nakajima T, Fukuda M, Ohta T
Cancer Res. 2007
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Contribution of BRCA1 and BRCA2 germline mutations to the incidence of early-onset breast cancer in Cyprus.
Loizidou M, Marcou Y, Anastasiadou V, Newbold R, Hadjisavvas A, Kyriacou K
Clin Genet. 2007
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Evaluation of BRCA1 and BRCA2 mutation prevalence, risk prediction models and a multistep testing approach in French-Canadian families with high risk of breast and ovarian cancer.
Simard J, Dumont M, Moisan AM, Gaborieau V, Malouin H, Durocher F, Chiquette J, Plante M, Avard D, Bessette P, Brousseau C, Dorval M, Godard B, Houde L, INHERIT BRCAs, Joly Y, Lajoie MA, Leblanc G, Lépine J, Lespérance B, Vézina H, Parboosingh J, Pichette R, Provencher L, Rhéaume J, Sinnett D, Samson C, Simard JC, Tranchant M, Voyer P, Easton D, Tavtigian SV, Knoppers BM, Laframboise R, Bridge P, Goldgar D
J Med Genet. 2007
PubMed ID: 16905680
Alternative splicing of breast cancer associated gene BRCA1 from breast cancer cell line.
Lixia M, Zhijian C, Chao S, Chaojiang G, Congyi Z
J Biochem Mol Biol. 2007
PubMed ID: 17244477
HIV-1 Vpr induces ATM-dependent cellular signal with enhanced homologous recombination.
Nakai-Murakami C, Shimura M, Kinomoto M, Takizawa Y, Tokunaga K, Taguchi T, Hoshino S, Miyagawa K, Sata T, Kurumizaka H, Yuo A, Ishizaka Y
Oncogene. 2007
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BRCA1 and BRCA2 germline mutations in Korean breast cancer patients at high risk of carrying mutations.
Ahn SH, Son BH, Yoon KS, Noh DY, Han W, Kim SW, Lee ES, Park HL, Hong YJ, Choi JJ, Moon SY, Kim MJ, Kim KH, Kwak BS, Cho DY
Cancer Lett. 2007
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Elevated levels of somatic mutation in a manifesting BRCA1 mutation carrier.
Grant SG, Das R, Cerceo CM, Rubinstein WS, Latimer JJ
Pathol Oncol Res. 2007
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Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells.
Aiyar SE, Cho H, Lee J, Li R
Int J Biol Sci. 2007
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Negative selection on BRCA1 susceptibility alleles sheds light on the population genetics of late-onset diseases and aging theory.
Pavard S, Metcalf CJ
PLoS ONE. 2007
PubMed ID: 18030340
Contribution of the BRCA1 and BRCA2 mutations to breast cancer in Tunisia.
Troudi W, Uhrhammer N, Sibille C, Dahan C, Mahfoudh W, Bouchlaka Souissi C, Jalabert T, Chouchane L, Bignon YJ, Ben Ayed F, Ben Ammar Elgaaied A
J Hum Genet. 2007
PubMed ID: 17922257
The BRCA1 Ashkenazi founder mutations occur on common haplotypes and are not highly correlated with anonymous single nucleotide polymorphisms likely to be used in genome-wide case-control association studies.
Pereira LH, Pineda MA, Rowe WH, Fonseca LR, Greene MH, Offit K, Ellis NA, Zhang J, Collins A, Struewing JP
BMC Genet. 2007
PubMed ID: 17916242
Association between the BRCA2 N372H variant and male breast cancer risk: a population-based case-control study in Tuscany, Central Italy.
Palli D, Falchetti M, Masala G, Lupi R, Sera F, Saieva C, D'Amico C, Ceroti M, Rizzolo P, Caligo MA, Zanna I, Ottini L
BMC Cancer. 2007
PubMed ID: 17767707
The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers.
Friedenson B
BMC Cancer. 2007
PubMed ID: 17683622
Germline mutations in the breast cancer susceptibility gene PTEN are rare in high-risk non-BRCA1/2 French Canadian breast cancer families.
Guénard F, Labrie Y, Ouellette G, Beauparlant CJ, Bessette P, Chiquette J, Laframboise R, Lépine J, Lespérance B, Pichette R, Plante M, Durocher F, INHERIT BRCAs
Fam Cancer. 2007
PubMed ID: 17636424
A review of histopathological subtypes of ovarian cancer in BRCA-related French Canadian cancer families.
Tonin PN, Maugard CM, Perret C, Mes-Masson AM, Provencher DM
Fam Cancer. 2007
PubMed ID: 17636423
BRCA1, BRCA2, TP53, and CDKN2A germline mutations in patients with breast cancer and cutaneous melanoma.
Monnerat C, Chompret A, Kannengiesser C, Avril MF, Janin N, Spatz A, Guinebretière JM, Marian C, Barrois M, Boitier F, Lenoir GM, Bressac-de Paillerets B
Fam Cancer. 2007
PubMed ID: 17624602
Multiplex SNaPshot for detection of BRCA1/2 common mutations in Spanish and Spanish related breast/ovarian cancer families.
Filippini S, Blanco A, Fernández-Marmiesse A, Alvarez-Iglesias V, Ruíz-Ponte C, Carracedo A, Vega A
BMC Med Genet. 2007
PubMed ID: 17603881
High occurrence of BRCA1 intragenic rearrangements in hereditary breast and ovarian cancer syndrome in the Czech Republic.
Vasickova P, Machackova E, Lukesova M, Damborsky J, Horky O, Pavlu H, Kuklova J, Kosinova V, Navratilova M, Foretova L
BMC Med Genet. 2007
PubMed ID: 17561994
Prognostic value of BRCA1 mutations in familial breast cancer patients affected by a second primary cancer.
Elsakov P, Kurtinaitis J, Ostapenko V
Fam Cancer. 2007
PubMed ID: 17520345
The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors.
Winter SL, Bosnoyan-Collins L, Pinnaduwage D, Andrulis IL
BMC Cancer. 2007
PubMed ID: 17511879
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
Evans TA, Raina AK, Delacourte A, Aprelikova O, Lee HG, Zhu X, Perry G, Smith MA
Int J Med Sci. 2007
PubMed ID: 17505559
Effects of BRCA1 transgene expression on murine mammary gland development and mutagen-induced mammary neoplasia.
Hoshino A, Yee CJ, Campbell M, Woltjer RL, Townsend RL, van der Meer R, Shyr Y, Holt JT, Moses HL, Jensen RA
Int J Biol Sci. 2007
PubMed ID: 17505536
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors.
Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z, Rasmussen KE, Jones LP, Assefnia S, Chandrasekharan S, Backlund MG, Yin Y, Khramtsov AI, Bastein R, Quackenbush J, Glazer RI, Brown PH, Green JE, Kopelovich L, Furth PA, Palazzo JP, Olopade OI, Bernard PS, Churchill GA, Van Dyke T, Perou CM
Genome Biol. 2007
PubMed ID: 17493263
Absence of the common IGF1 19 CA-repeat allele is more common among BRCA1 mutation carriers than among non-carriers from BRCA1 families.
Henningson M, Bågeman E, Sandberg T, Borg A, Olsson H, Jernström H
Fam Cancer. 2007
PubMed ID: 17484040
655Val and 1170Pro ERBB2 SNPs in familial breast cancer risk and BRCA1 alterations.
Tommasi S, Fedele V, Lacalamita R, Bruno M, Schittulli F, Ginzinger D, Scott G, Eppenberger-Castori S, Calistri D, Casadei S, Seymour I, Longo S, Giannelli G, Pilato B, Simone G, Benz CC, Paradiso A
Cell Oncol. 2007
PubMed ID: 17452776
Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk.
Baynes C, Healey CS, Pooley KA, Scollen S, Luben RN, Thompson DJ, Pharoah PD, Easton DF, Ponder BA, Dunning AM, SEARCH breast cancer study
Breast Cancer Res. 2007
PubMed ID: 17428325
Identification of women with an increased risk of developing radiation-induced breast cancer: a case only study.
Broeks A, Braaf LM, Huseinovic A, Nooijen A, Urbanus J, Hogervorst FB, Schmidt MK, Klijn JG, Russell NS, Van Leeuwen FE, Van 't Veer LJ
Breast Cancer Res. 2007
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[Analysis of BRCA1/2 and CHEK2 mutations in ovarian cancer and primary multiple tumors involving the ovaries. Patients of Russian population using biochips]
Fedorova OE, Liubchenko LN, Paiadini IuG, Kazubskaia TP, Amosenko FA, Gar'kavtseva RF, Zasedatelev AS, Nasedkina TV
Mol Biol (Mosk). 2007
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Founder mutations in early-onset, familial and bilateral breast cancer patients from Russia.
Sokolenko AP, Rozanov ME, Mitiushkina NV, Sherina NY, Iyevleva AG, Chekmariova EV, Buslov KG, Shilov ES, Togo AV, Bit-Sava EM, Voskresenskiy DA, Chagunava OL, Devilee P, Cornelisse C, Semiglazov VF, Imyanitov EN
Fam Cancer. 2007
PubMed ID: 17333477
Gene promoter hypermethylation in ductal lavage fluid from healthy BRCA gene mutation carriers and mutation-negative controls.
Locke I, Kote-Jarai Z, Fackler MJ, Bancroft E, Osin P, Nerurkar A, Izatt L, Pichert G, Gui GP, Eeles RA
Breast Cancer Res. 2007
PubMed ID: 17324252
The spectrum and incidence of BRCA1 pathogenic mutations in Slovak breast/ovarian cancer families.
Konecny M, Vizvaryova M, Weismanova E, Ilencikova D, Mlkva I, Weismann P, Machackova G, Kausitz J
Neoplasma. 2007
PubMed ID: 17319787
A novel BRCA-1 mutation in Arab kindred from east Jerusalem with breast and ovarian cancer.
Kadouri L, Bercovich D, Elimelech A, Lerer I, Sagi M, Glusman G, Shochat C, Korem S, Hamburger T, Nissan A, Abu-Halaf N, Badrriyah M, Abeliovich D, Peretz T
BMC Cancer. 2007
PubMed ID: 17233897
Reproductive risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study.
McLaughlin JR, Risch HA, Lubinski J, Moller P, Ghadirian P, Lynch H, Karlan B, Fishman D, Rosen B, Neuhausen SL, Offit K, Kauff N, Domchek S, Tung N, Friedman E, Foulkes W, Sun P, Narod SA, Hereditary Ovarian Cancer Clinical Study Group
Lancet Oncol. 2007
PubMed ID: 17196508
Genetic instability in the RAD51 and BRCA1 regions in breast cancer.
Nowacka-Zawisza M, Bryś M, Romanowicz-Makowska H, Kulig A, Krajewska WM
Cell Mol Biol Lett. 2007
PubMed ID: 17180310
Improved survival in BRCA2 carriers with ovarian cancer.
Pal T, Permuth-Wey J, Kapoor R, Cantor A, Sutphen R
Fam Cancer. 2007
PubMed ID: 17160431
Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes.
Clark-Knowles KV, Garson K, Jonkers J, Vanderhyden BC
Exp Cell Res. 2007
PubMed ID: 17070800
Prognosis of early-onset breast cancer based on BRCA1/2 mutation status in a French population-based cohort and review.
Bonadona V, Dussart-Moser S, Voirin N, Sinilnikova OM, Mignotte H, Mathevet P, Brémond A, Treilleux I, Martin A, Romestaing P, Raudrant D, Rudigoz RC, Lenoir GM, Lasset C
Breast Cancer Res Treat. 2007
PubMed ID: 17061047
Risks of cancer due to a single BRCA1 mutation in an extended Utah kindred.
Vogl FD, Badzioch MD, Steele L, Neuhausen SL, Goldgar DE
Fam Cancer. 2007
PubMed ID: 17051349
Occurrence of both breast and ovarian cancer in a woman is a marker for the BRCA gene mutations: a population-based study from western Sweden.
Einbeigi Z, Bergman A, Meis-Kindblom JM, Flodin A, Bjursell C, Martinsson T, Kindblom LG, Wahlström J, Wallgren A, Nordling M, Karlsson P
Fam Cancer. 2007
PubMed ID: 16944270
Heterozygote BRCA1 status and skewed chromosome X inactivation.
Helbling-Leclere A, Lenoir GM, Feunteun J
Fam Cancer. 2007
PubMed ID: 16944269
Tumor suppressor BRCA1 inhibits a breast cancer-associated promoter of the aromatase gene (CYP19) in human adipose stromal cells.
Ghosh S, Lu Y, Katz A, Hu Y, Li R
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 16940470
Prevalence of BRCA1 and BRCA2 mutations in Pakistani breast and ovarian cancer patients.
Rashid MU, Zaidi A, Torres D, Sultan F, Benner A, Naqvi B, Shakoori AR, Seidel-Renkert A, Farooq H, Narod S, Amin A, Hamann U
Int J Cancer. 2006
PubMed ID: 16998791
Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada.
Risch HA, McLaughlin JR, Cole DE, Rosen B, Bradley L, Fan I, Tang J, Li S, Zhang S, Shaw PA, Narod SA
J Natl Cancer Inst. 2006
PubMed ID: 17148771
BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin.
Pageau GJ, Lawrence JB
J Cell Biol. 2006
PubMed ID: 17145961
[Analysis of loss of heterozygosity and microsatellite instability RAD52, RAD54 and RAD54B gene and BRCA1 gene mutation in breast cancer]
Romanowicz-Makowska H, Smolarz B
Pol Merkur Lekarski. 2006
PubMed ID: 17405295
Ubiquitin transfer from the E2 perspective: why is UbcH5 so promiscuous?
Brzovic PS, Klevit RE
Cell Cycle. 2006
PubMed ID: 17218787
"Similarity trap" in protein-protein interactions could be carcinogenic: simulations of p53 core domain complexed with 53BP1 and BRCA1 BRCT domains.
Liu J, Pan Y, Ma B, Nussinov R
Structure. 2006
PubMed ID: 17161371
Acute chemotherapy-related toxicity is not increased in BRCA1 and BRCA2 mutation carriers treated for breast cancer in the United Kingdom.
Shanley S, McReynolds K, Ardern-Jones A, Ahern R, Fernando I, Yarnold J, Evans G, Eccles D, Hodgson S, Ashley S, Ashcroft L, Tutt A, Bancroft E, Short S, Smith I, Gui G, Royal Marsden NHS Foundation Trust, Barr L, Baildam A, Howell A, Royle G, Pierce L, Easton D, Eeles R
Clin Cancer Res. 2006
PubMed ID: 17145825
Late toxicity is not increased in BRCA1/BRCA2 mutation carriers undergoing breast radiotherapy in the United Kingdom.
Shanley S, McReynolds K, Ardern-Jones A, Ahern R, Fernando I, Yarnold J, Evans G, Eccles D, Hodgson S, Ashley S, Ashcroft L, Tutt A, Bancroft E, Short S, Gui G, Breast Unit of the Royal Marsden NHS Foundation Trust, Barr L, Baildam A, Howell A, Royle G, Pierce L, Easton D, Eeles R
Clin Cancer Res. 2006
PubMed ID: 17145824
HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT.
Andersen JL, DeHart JL, Zimmerman ES, Ardon O, Kim B, Jacquot G, Benichou S, Planelles V
PLoS Pathog. 2006
PubMed ID: 17140287
Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist.
Poole AJ, Li Y, Kim Y, Lin SC, Lee WH, Lee EY
Science. 2006
PubMed ID: 17138902
Mutation analysis of BRCA1 and BRCA2 from 793 Korean patients with sporadic breast cancer.
Han SH, Lee KR, Lee DG, Kim BY, Lee KE, Chung WS
Clin Genet. 2006
PubMed ID: 17100994
Influence of polymorphisms in xenobiotic-metabolizing genes and DNA-repair genes on diepoxybutane-induced SCE frequency.
Laczmanska I, Gil J, Karpinski P, Stembalska A, Kozlowska J, Busza H, Trusewicz A, Pesz K, Ramsey D, Schlade-Bartusiak K, Blin N, Sasiadek MM
Environ Mol Mutagen. 2006
PubMed ID: 17078101
Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions.
Bartz SR, Zhang Z, Burchard J, Imakura M, Martin M, Palmieri A, Needham R, Guo J, Gordon M, Chung N, Warrener P, Jackson AL, Carleton M, Oatley M, Locco L, Santini F, Smith T, Kunapuli P, Ferrer M, Strulovici B, Friend SH, Linsley PS
Mol Cell Biol. 2006
PubMed ID: 17000754
Direct-to-patient BRCA1 testing: the Twoj Styl experience.
Gronwald J, Huzarski T, Byrski T, Debniak T, Metcalfe K, Narod SA, Lubiński J
Breast Cancer Res Treat. 2006
PubMed ID: 16807675
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Effect of mammography on breast cancer risk in women with mutations in BRCA1 or BRCA2.
Goldfrank D, Chuai S, Bernstein JL, Ramon Y Cajal T, Lee JB, Alonso MC, Diez O, Baiget M, Kauff ND, Offit K, Robson M
Cancer Epidemiol Biomarkers Prev. 2006
PubMed ID: 17119064
BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells.
Lu M, Chen D, Lin Z, Reierstad S, Trauernicht AM, Boyer TG, Bulun SE
J Clin Endocrinol Metab. 2006
PubMed ID: 16940443
Novel BRCA1 and BRCA2 germline mutations and assessment of mutation spectrum and prevalence in Italian breast and/or ovarian cancer families.
Giannini G, Capalbo C, Ristori E, Ricevuto E, Sidoni T, Buffone A, Cortesi E, Marchetti P, Scambia G, Tomao S, Rinaldi C, Zani M, Ferraro S, Frati L, Screpanti I, Gulino A
Breast Cancer Res Treat. 2006
PubMed ID: 16847550
Premature menopause in patients with BRCA1 gene mutation.
Rzepka-Górska I, Tarnowski B, Chudecka-Głaz A, Górski B, Zielińska D, Tołoczko-Grabarek A
Breast Cancer Res Treat. 2006
PubMed ID: 16773440
Reduced BRCA1 expression due to promoter hypermethylation in therapy-related acute myeloid leukaemia.
Scardocci A, Guidi F, D'Alo' F, Gumiero D, Fabiani E, Diruscio A, Martini M, Larocca LM, Zollino M, Hohaus S, Leone G, Voso MT
Br J Cancer. 2006
PubMed ID: 17047656
Identification of BRCA1 and BRCA2 mutations from Korean breast cancer patients using denaturing HPLC.
Kim BY, Lee DG, Lee KR, Han SH, Surendran S, Han CW, Chung N
Biochem Biophys Res Commun. 2006
PubMed ID: 16949048
The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
Science. 2006
PubMed ID: 16959974
Caveolin-1 controls BRCA1 gene expression and cellular localization in human breast cancer cells.
Glait C, Ravid D, Lee SW, Liscovitch M, Werner H
FEBS Lett. 2006
PubMed ID: 16979166
[Prevalence of Val158Met polymorphism in COMT gene on non-BRCA1/2 hereditary breast cancer]
Song CG, Hu Z, Yuan WT, Di GH, Shen ZZ, Huang W, Shao ZM
Zhonghua Wai Ke Za Zhi. 2006
PubMed ID: 17217814
Basal repression of BRCA1 by multiple E2Fs and pocket proteins at adjacent E2F sites.
Bindra RS, Glazer PM
Cancer Biol Ther. 2006
PubMed ID: 17106239
BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50.
Haile RW, Thomas DC, McGuire V, Felberg A, John EM, Milne RL, Hopper JL, Jenkins MA, Levine AJ, Daly MM, Buys SS, Senie RT, Andrulis IL, Knight JA, Godwin AK, Southey M, McCredie MR, Giles GG, Andrews L, Tucker K, Miron A, Apicella C, Tesoriero A, Bane A, Pike MC, kConFab Investigators, Ontario Cancer Genetics Network Investigators, Whittemore AS
Cancer Epidemiol Biomarkers Prev. 2006
PubMed ID: 17021353
Missense mutations of BRCA1 gene affect the binding with p53 both in vitro and in vivo.
Quaresima B, Faniello MC, Baudi F, Crugliano T, Di Sanzo M, Cuda G, Costanzo F, Venuta S
Oncol Rep. 2006
PubMed ID: 16969499
The 185delAG mutation (c.68_69delAG) in the BRCA1 gene triggers translation reinitiation at a downstream AUG codon.
Buisson M, Anczuków O, Zetoune AB, Ware MD, Mazoyer S
Hum Mutat. 2006
PubMed ID: 16941470
BRCA1-IRIS regulates cyclin D1 expression in breast cancer cells.
Nakuci E, Mahner S, Direnzo J, ElShamy WM
Exp Cell Res. 2006
PubMed ID: 16860316
Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity.
Shen M, Lan Q, Zhang L, Chanock S, Li G, Vermeulen R, Rappaport SM, Guo W, Hayes RB, Linet M, Yin S, Yeager M, Welch R, Forrest MS, Rothman N, Smith MT
Carcinogenesis. 2006
PubMed ID: 16728435
Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects.
Evers B, Jonkers J
Oncogene. 2006
PubMed ID: 16998503
The role of BRCA1 in transcriptional regulation and cell cycle control.
Mullan PB, Quinn JE, Harkin DP
Oncogene. 2006
PubMed ID: 16998500
Basal-like breast cancer and the BRCA1 phenotype.
Turner NC, Reis-Filho JS
Oncogene. 2006
PubMed ID: 16998499
Pathology and gene expression of hereditary breast tumors associated with BRCA1, BRCA2 and CHEK2 gene mutations.
Honrado E, Osorio A, Palacios J, Benitez J
Oncogene. 2006
PubMed ID: 16998498
Clinical management of BRCA1 and BRCA2 mutation carriers.
Domchek SM, Weber BL
Oncogene. 2006
PubMed ID: 16998496
A mouse model for the molecular characterization of brca1-associated ovarian carcinoma.
Xing D, Orsulic S
Cancer Res. 2006
PubMed ID: 16982732
BRCA1 suppresses osteopontin-mediated breast cancer.
El-Tanani MK, Campbell FC, Crowe P, Erwin P, Harkin DP, Pharoah P, Ponder B, Rudland PS
J Biol Chem. 2006
PubMed ID: 16807234
Medullary carcinoma of breast with a novel germline mutation 1123T >G in exon 11 of BRCA1.
Moattar T, Kausar T, Aban M, Khan S, Pervez S
J Coll Physicians Surg Pak. 2006
PubMed ID: 16945238
Hyperplasia and spontaneous tumor development in the gynecologic system in mice lacking the BRCA1-Delta11 isoform.
Kim SS, Cao L, Lim SC, Li C, Wang RH, Xu X, Bachelier R, Deng CX
Mol Cell Biol. 2006
PubMed ID: 16943438
Childhood cancer in families with and without BRCA1 or BRCA2 mutations ascertained at a high-risk breast cancer clinic.
Brooks GA, Stopfer JE, Erlichman J, Davidson R, Nathanson KL, Domchek SM
Cancer Biol Ther. 2006
PubMed ID: 16931905
Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1.
Muraoka-Cook RS, Caskey LS, Sandahl MA, Hunter DM, Husted C, Strunk KE, Sartor CI, Rearick WA, McCall W, Sgagias MK, Cowan KH, Earp HS
Mol Cell Biol. 2006
PubMed ID: 16914727
BRCA1-positive breast cancers in young women from Poland.
Lubiński J, Górski B, Huzarski T, Byrski T, Gronwald J, Serrano-Fernández P, Domagała W, Chosia M, Uciński M, Grzybowska E, Lange D, Maka B, Mackiewicz A, Karczewska A, Breborowicz J, Lamperska K, Stawicka M, Gozdecka-Grodecka S, Bebenek M, Sorokin D, Wojnar A, Haus O, Sir J, Mierzwa T, Niepsuj S, Gugała K, Góźdź S, Sygut J, Kozak-Klonowska B, Musiatowicz B, Posmyk M, Kordek R, Morawiec M, Zambrano O, Waśko B, Fudali L, Skret J, Surdyka D, Urbański K, Mituś J, Ryś J, Szwiec M, Rozmiarek A, Dziuba I, Wandzel P, Wiśniowski R, Szczylik C, Kozak A, Kozłowski W, Narod SA
Breast Cancer Res Treat. 2006
PubMed ID: 16541315
BRCA1 interacts with poly(A)-binding protein: implication of BRCA1 in translation regulation.
Dizin E, Gressier C, Magnard C, Ray H, Décimo D, Ohlmann T, Dalla Venezia N
J Biol Chem. 2006
PubMed ID: 16782705
Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years.
Malone KE, Daling JR, Doody DR, Hsu L, Bernstein L, Coates RJ, Marchbanks PA, Simon MS, McDonald JA, Norman SA, Strom BL, Burkman RT, Ursin G, Deapen D, Weiss LK, Folger S, Madeoy JJ, Friedrichsen DM, Suter NM, Humphrey MC, Spirtas R, Ostrander EA
Cancer Res. 2006
PubMed ID: 16912212
Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers.
Deans AJ, Khanna KK, McNees CJ, Mercurio C, Heierhorst J, McArthur GA
Cancer Res. 2006
PubMed ID: 16912201
Diet, lifestyle and BRCA-related breast cancer risk among French-Canadians.
Nkondjock A, Robidoux A, Paredes Y, Narod SA, Ghadirian P
Breast Cancer Res Treat. 2006
PubMed ID: 16541324
The BRCA1 COOH-terminal region acts as an RNA polymerase II carboxyl-terminal domain kinase inhibitor that modulates p21WAF1/CIP1 expression.
Moisan A, Gaudreau L
J Biol Chem. 2006
PubMed ID: 16735508
Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members.
Shukla V, Coumoul X, Cao L, Wang RH, Xiao C, Xu X, Andò S, Yakar S, Leroith D, Deng C
Cancer Res. 2006
PubMed ID: 16849561
Low frequency of large genomic rearrangements of BRCA1 and BRCA2 in western Denmark.
Thomassen M, Gerdes AM, Cruger D, Jensen PK, Kruse TA
Cancer Genet Cytogenet. 2006
PubMed ID: 16843109
Genetic instability of BRCA1 gene at locus D17S855 is related to clinicopathological behaviors of gastric cancer from Chinese population.
Chen XR, Zhang WZ, Lin XQ, Wang JW
World J Gastroenterol. 2006
PubMed ID: 16830385
Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature.
Furuta S, Wang JM, Wei S, Jeng YM, Jiang X, Gu B, Chen PL, Lee EY, Lee WH
Cancer Cell. 2006
PubMed ID: 16843262
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP.
Yu X, Fu S, Lai M, Baer R, Chen J
Genes Dev. 2006
PubMed ID: 16818604
Gross rearrangements in BRCA1 but not BRCA2 play a notable role in predisposition to breast and ovarian cancer in high-risk families of German origin.
Preisler-Adams S, Schönbuchner I, Fiebig B, Welling B, Dworniczak B, Weber BH
Cancer Genet Cytogenet. 2006
PubMed ID: 16772120
The prevalence of germline BRCA1 and BRCA2 mutations in young women with breast cancer undergoing breast-conservation therapy.
Golshan M, Miron A, Nixon AJ, Garber JE, Cash EP, Iglehart JD, Harris JR, Wong JS
Am J Surg. 2006
PubMed ID: 16769276
Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut.
Shen M, Zheng T, Lan Q, Zhang Y, Zahm SH, Wang SS, Holford TR, Leaderer B, Yeager M, Welch R, Kang D, Boyle P, Zhang B, Zou K, Zhu Y, Chanock S, Rothman N
Hum Genet. 2006
PubMed ID: 16738949
High frequency of BRCA1 5382insC mutation in Russian breast cancer patients.
Sokolenko AP, Mitiushkina NV, Buslov KG, Bit-Sava EM, Iyevleva AG, Chekmariova EV, Kuligina ESh, Ulibina YM, Rozanov ME, Suspitsin EN, Matsko DE, Chagunava OL, Trofimov DY, Devilee P, Cornelisse C, Togo AV, Semiglazov VF, Imyanitov EN
Eur J Cancer. 2006
PubMed ID: 16737811
Analysis of loss of heterozygosity and immunohistochemistry in BRCA1 gene in sporadic breast cancers.
Dinesh KP, Devaraj H, Murugan V, Rajaraman R, Niranjali S
Mol Cell Biochem. 2006
PubMed ID: 16718381
Primary structure-based function characterization of BRCT domain replicates in BRCA1.
Chen Y, Borowicz S, Fackenthal J, Collart FR, Myatt E, Moy S, Babnigg G, Wilton R, Boernke WE, Schiffer M, Stevens FJ, Olopade OI
Biochem Biophys Res Commun. 2006
PubMed ID: 16677609
ACCA phosphopeptide recognition by the BRCT repeats of BRCA1.
Ray H, Moreau K, Dizin E, Callebaut I, Venezia ND
J Mol Biol. 2006
PubMed ID: 16698035
Analysis of RAD51 polymorphism and BRCA1 mutations in Polish women with breast cancer.
Romanowicz-Makowska H, Smolarz B, Zadrozny M, Kulig A
Exp Oncol. 2006
PubMed ID: 16837909
BRCA1 and BRCA2 genetic testing in Italian breast and/or ovarian cancer families: mutation spectrum and prevalence and analysis of mutation prediction models.
Capalbo C, Ricevuto E, Vestri A, Ristori E, Sidoni T, Buffone O, Adamo B, Cortesi E, Marchetti P, Scambia G, Tomao S, Rinaldi C, Zani M, Ferraro S, Frati L, Screpanti I, Gulino A, Giannini G
Ann Oncol. 2006
PubMed ID: 16760289
Y179C, F486L and N550H are BRCA1 variants that may be associated with breast cancer in a Sicilian family: results of a 5-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study.
Augello C, Bruno L, Bazan V, Calò V, Agnese V, Corsale S, Cascio S, Gargano G, Terrasi M, Barbera F, Fricano S, Adamo B, Valerio MR, Colucci G, Sumarcz E, Russo A, Gruppo Oncologico dell'Italia Meridionale
Ann Oncol. 2006
PubMed ID: 16760288
An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication.
Zhu W, Dutta A
Mol Cell Biol. 2006
PubMed ID: 16738325
"Social separation" among women under 40 years of age diagnosed with breast cancer and carrying a BRCA1 or BRCA2 mutation.
Kenen R, Ardern-Jones A, Eeles R
J Genet Couns. 2006
PubMed ID: 16724273
BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells.
Kang HJ, Kim HJ, Kim SK, Barouki R, Cho CH, Khanna KK, Rosen EM, Bae I
J Biol Chem. 2006
PubMed ID: 16567799
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY
Cell. 2006
PubMed ID: 16713569
ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.
Cao L, Kim S, Xiao C, Wang RH, Coumoul X, Wang X, Li WM, Xu XL, De Soto JA, Takai H, Mai S, Elledge SJ, Motoyama N, Deng CX
EMBO J. 2006
PubMed ID: 16675955
A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.
Polanowska J, Martin JS, Garcia-Muse T, Petalcorin MI, Boulton SJ
EMBO J. 2006
PubMed ID: 16628214
BRCA1 plays a role in the hypoxic response by regulating HIF-1alpha stability and by modulating vascular endothelial growth factor expression.
Kang HJ, Kim HJ, Rih JK, Mattson TL, Kim KW, Cho CH, Isaacs JS, Bae I
J Biol Chem. 2006
PubMed ID: 16543242
Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study.
Narod SA, Lubinski J, Ghadirian P, Lynch HT, Moller P, Foulkes WD, Rosen B, Kim-Sing C, Isaacs C, Domchek S, Domcheck S, Sun P, Hereditary Breast Cancer Clinical Study Group
Lancet Oncol. 2006
PubMed ID: 16648044
BRCA1, BRCA2 and TP53 mutations in very early-onset breast cancer with associated risks to relatives.
Lalloo F, Varley J, Moran A, Ellis D, O'dair L, Pharoah P, Antoniou A, Hartley R, Shenton A, Seal S, Bulman B, Howell A, Evans DG
Eur J Cancer. 2006
PubMed ID: 16644204
Intronic alterations in BRCA1 and BRCA2: effect on mRNA splicing fidelity and expression.
Chen X, Truong TT, Weaver J, Bove BA, Cattie K, Armstrong BA, Daly MB, Godwin AK
Hum Mutat. 2006
PubMed ID: 16619214
Tamoxifen and contralateral breast cancer in BRCA1 and BRCA2 carriers: an update.
Gronwald J, Tung N, Foulkes WD, Offit K, Gershoni R, Daly M, Kim-Sing C, Olsson H, Ainsworth P, Eisen A, Saal H, Friedman E, Olopade O, Osborne M, Weitzel J, Lynch H, Ghadirian P, Lubinski J, Sun P, Narod SA, Hereditary Breast Cancer Clinical Study Group
Int J Cancer. 2006
PubMed ID: 16331614
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C
Nature. 2006
PubMed ID: 16625196
Pregnancies, breast-feeding, and breast cancer risk in the International BRCA1/2 Carrier Cohort Study (IBCCS).
Andrieu N, Goldgar DE, Easton DF, Rookus M, Brohet R, Antoniou AC, Peock S, Evans G, Eccles D, Douglas F, Noguès C, Gauthier-Villars M, Chompret A, Van Leeuwen FE, Kluijt I, Benitez J, Arver B, Olah E, Chang-Claude J, EMBRACE, GENEPSO, GEO-HEBON, IBCCS Collaborators Group
J Natl Cancer Inst. 2006
PubMed ID: 16622123
Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer.
Damaraju S, Murray D, Dufour J, Carandang D, Myrehaug S, Fallone G, Field C, Greiner R, Hanson J, Cass CE, Parliament M
Clin Cancer Res. 2006
PubMed ID: 16638864
ATM activation by ionizing radiation requires BRCA1-associated BAAT1.
Aglipay JA, Martin SA, Tawara H, Lee SW, Ouchi T
J Biol Chem. 2006
PubMed ID: 16452482
BACH1 is a DNA repair protein supporting BRCA1 damage response.
Peng M, Litman R, Jin Z, Fong G, Cantor SB
Oncogene. 2006
PubMed ID: 16462773
Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis.
Smolen GA, Muir B, Mohapatra G, Barmettler A, Kim WJ, Rivera MN, Haserlat SM, Okimoto RA, Kwak E, Dahiya S, Garber JE, Bell DW, Sgroi DC, Chin L, Deng CX, Haber DA
Cancer Res. 2006
PubMed ID: 16585167
DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis.
Xu Y
Nat Rev Immunol. 2006
PubMed ID: 16498454
A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination.
Brzovic PS, Lissounov A, Christensen DE, Hoyt DW, Klevit RE
Mol Cell. 2006
PubMed ID: 16543155
A role for Brca1 in chromosome end maintenance.
McPherson JP, Hande MP, Poonepalli A, Lemmers B, Zablocki E, Migon E, Shehabeldin A, Porras A, Karaskova J, Vukovic B, Squire J, Hakem R
Hum Mol Genet. 2006
PubMed ID: 16446310
Development and characterization of a hypomorphic Smith-Lemli-Opitz syndrome mouse model and efficacy of simvastatin therapy.
Correa-Cerro LS, Wassif CA, Kratz L, Miller GF, Munasinghe JP, Grinberg A, Fliesler SJ, Porter FD
Hum Mol Genet. 2006
PubMed ID: 16446309
Familial clustering of site-specific cancer risks associated with BRCA1 and BRCA2 mutations in the Ashkenazi Jewish population.
Simchoni S, Friedman E, Kaufman B, Gershoni-Baruch R, Orr-Urtreger A, Kedar-Barnes I, Shiri-Sverdlov R, Dagan E, Tsabari S, Shohat M, Catane R, King MC, Lahad A, Levy-Lahad E
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16537453
BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1).
Williamson EA, Wolf I, O'Kelly J, Bose S, Tanosaki S, Koeffler HP
Oncogene. 2006
PubMed ID: 16331276
Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer.
Grabsch H, Dattani M, Barker L, Maughan N, Maude K, Hansen O, Gabbert HE, Quirke P, Mueller W
Clin Cancer Res. 2006
PubMed ID: 16533773
Disruption of BRCA1 function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines.
French JD, Dunn J, Smart CE, Manning N, Brown MA
Genes Chromosomes Cancer. 2006
PubMed ID: 16283620
Characterization of BRCA1 and BRCA2 mutations in a large United States sample.
Chen S, Iversen ES, Friebel T, Finkelstein D, Weber BL, Eisen A, Peterson LE, Schildkraut JM, Isaacs C, Peshkin BN, Corio C, Leondaridis L, Tomlinson G, Dutson D, Kerber R, Amos CI, Strong LC, Berry DA, Euhus DM, Parmigiani G
J Clin Oncol. 2006
PubMed ID: 16484695
BRCA1 DNA-binding activity is stimulated by BARD1.
Simons AM, Horwitz AA, Starita LM, Griffin K, Williams RS, Glover JN, Parvin JD
Cancer Res. 2006
PubMed ID: 16489000
BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase.
Moreau K, Dizin E, Ray H, Luquain C, Lefai E, Foufelle F, Billaud M, Lenoir GM, Venezia ND
J Biol Chem. 2006
PubMed ID: 16326698
Substrates of the BRCA1-dependent ubiquitin ligase.
Starita LM, Parvin JD
Cancer Biol Ther. 2006
PubMed ID: 16479151
[BRCA1 and BRCA2 gene mutations of familial breast cancer from Shanghai in China]
Song CG, Hu Z, Yuan WT, Di GH, Shen ZZ, Huang W, Shao ZM
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006
PubMed ID: 16456781
Racial differences in the incidence of BRCA1 and BRCA2 mutations in a cohort of early onset breast cancer patients: African American compared to white women.
Haffty BG, Silber A, Matloff E, Chung J, Lannin D
J Med Genet. 2006
PubMed ID: 15983021
An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification.
Oishi H, Kitagawa H, Wada O, Takezawa S, Tora L, Kouzu-Fujita M, Takada I, Yano T, Yanagisawa J, Kato S
J Biol Chem. 2006
PubMed ID: 16260778
Lack of germ-line promoter methylation in BRCA1-negative families with familial breast cancer.
Chen Y, Toland AE, McLennan J, Fridlyand J, Crawford B, Costello JF, Ziegler JL
Genet Test. 2006
PubMed ID: 17253935
A novel frequent BRCA1 allele in Chinese patients with breast cancer.
Zhou D, Xiong W, Xu H, Shao C
J Huazhong Univ Sci Technolog Med Sci. 2006
PubMed ID: 17219973
Tumor-protective and tumor-promoting actions of dietary whey proteins in an N-methyl-N-nitrosourea model of rat mammary carcinogenesis.
Eason RR, Till SR, Frank JA, Badger TM, Korourian S, Simmen FA, Simmen RC
Nutr Cancer. 2006
PubMed ID: 17044772
The P1812A and P25T BRCA1 and the 5164del4 BRCA2 mutations: occurrence in high-risk non-Ashkenazi Jews.
Kaufman B, Laitman Y, Carvalho MA, Edelman L, Menachem TD, Zidan J, Monteiro AN, Friedman E
Genet Test. 2006
PubMed ID: 17020472
Contribution of germline BRCA1 and BRCA2 sequence alterations to breast cancer in Northern India.
Saxena S, Chakraborty A, Kaushal M, Kotwal S, Bhatanager D, Mohil RS, Chintamani C, Aggarwal AK, Sharma VK, Sharma PC, Lenoir G, Goldgar DE, Szabo CI
BMC Med Genet. 2006
PubMed ID: 17018160
Insulin-like growth factor-1 genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating insulin-like growth factor-1 levels: implications for risk of early-onset breast cancer in young women from heredita
Jernström H, Sandberg T, Bågeman E, Borg A, Olsson H
Int J Gynecol Cancer. 2006
PubMed ID: 17010055
BRCA1 and BRCA2 germline mutational spectrum and evidence for genetic anticipation in Portuguese breast/ovarian cancer families.
Peixoto A, Salgueiro N, Santos C, Varzim G, Rocha P, Soares MJ, Pereira D, Rodrigues H, Bento MJ, Fráguas A, Moura G, Regateiro F, Castedo S, Teixeira MR
Fam Cancer. 2006
PubMed ID: 16826315
No Evidence of BRCA1/2 genomic rearrangements in high-risk French-Canadian breast/ovarian cancer families.
Moisan AM, Fortin J, Dumont M, Samson C, Bessette P, Chiquette J, Laframboise R, Lépine J, Lespérance B, Pichette R, Plante M, Provencher L, Voyer P, Goldgar D, Bridge P, Simard J
Genet Test. 2006
PubMed ID: 16792513
Are CYP17 genotypes a biomarker for ovarian cancer in patients with cancer history in their family?
Yazici H, Tigli H, Kadehci Z, Kucucuk S, Saip P, Issever H, Ozcelik H, Dalay N
Oncol Res. 2006
PubMed ID: 16783967
Low prevalence of BRCA1 exon rearrangements in familial and young sporadic breast cancer patients.
Ellis D, Patel Y, Yau SC, Hodgson SV, Abbs SJ
Fam Cancer. 2006
PubMed ID: 16724249
Accuracy of BRCA1 and BRCA2 founder mutation analysis in formalin-fixed and paraffin-embedded (FFPE) tissue.
Adank MA, Brogi E, Bogomolniy F, Wadsworth EA, Lafaro KJ, Yee CJ, Kirchhoff T, Meijers-Heijboer EJ, Kauff ND, Boyd J, Offit K
Fam Cancer. 2006
PubMed ID: 16724247
Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers.
Friedman E, Kotsopoulos J, Lubinski J, Lynch HT, Ghadirian P, Neuhausen SL, Isaacs C, Weber B, Foulkes WD, Moller P, Rosen B, Kim-Sing C, Gershoni-Baruch R, Ainsworth P, Daly M, Tung N, Eisen A, Olopade OI, Karlan B, Saal HM, Garber JE, Rennert G, Gilchrist D, Eng C, Offit K, Osborne M, Sun P, Narod SA, Hereditary Breast Cancer Clinical Study Group
Breast Cancer Res. 2006
PubMed ID: 16563180
Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers.
Copson ER, White HE, Blaydes JP, Robinson DO, Johnson PW, Eccles DM
BMC Cancer. 2006
PubMed ID: 16563154
BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution.
Deng CX
Nucleic Acids Res. 2006
PubMed ID: 16522651
CAG repeat length in exon 1 of the androgen receptor gene is related to age of diagnosis but not germ line BRCA1 mutation status in ovarian cancer.
Kim SC, Ju W, Mahavni V, Geisler JP, Buller RE
Int J Gynecol Cancer. 2006
PubMed ID: 16515589
The frequent BRCA1 mutation 1135insA has multiple origins: a haplotype study in different populations.
Rudkin TM, Hamel N, Galvez M, Hogervorst F, Gille JJ, Møller P, Apold J, Foulkes WD
BMC Med Genet. 2006
PubMed ID: 16509964
Advances in the recognition of tubal intraepithelial carcinoma: applications to cancer screening and the pathogenesis of ovarian cancer.
Lee Y, Medeiros F, Kindelberger D, Callahan MJ, Muto MG, Crum CP
Adv Anat Pathol. 2006
PubMed ID: 16462151
[Prophylactic oophorectomy among carriers of BRCA1/2 mutations--demographic and pathologic data]
Daum H, Sagi M, Pikarsky E, Pruss D, Hamburger T, Peretz T
Harefuah. 2006
PubMed ID: 16450717
New role for nuclear hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines.
Crowe DL, Lee MK
Breast Cancer Res. 2006
PubMed ID: 16417649
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.
Greenberg RA, Sobhian B, Pathania S, Cantor SB, Nakatani Y, Livingston DM
Genes Dev. 2006
PubMed ID: 16391231
Incidence of BRCA1 and BRCA2 mutations in 54 Chilean families with breast/ovarian cancer, genotype-phenotype correlations.
Gallardo M, Silva A, Rubio L, Alvarez C, Torrealba C, Salinas M, Tapia T, Faundez P, Palma L, Riccio ME, Paredes H, Rodriguez M, Cruz A, Rousseau C, King MC, Camus M, Alvarez M, Carvallo P
Breast Cancer Res Treat. 2006
PubMed ID: 16261400
Hormone replacement therapy and the risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers.
Kotsopoulos J, Lubinski J, Neuhausen SL, Lynch HT, Rosen B, Ainsworth P, Moller P, Ghadirian P, Isaacs C, Karlan B, Sun P, Narod SA
Gynecol Oncol. 2006
PubMed ID: 16137751
The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells.
Ma Y, Katiyar P, Jones LP, Fan S, Zhang Y, Furth PA, Rosen EM
Mol Endocrinol. 2006
PubMed ID: 16109739
Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers.
Nkondjock A, Ghadirian P, Kotsopoulos J, Lubinski J, Lynch H, Kim-Sing C, Horsman D, Rosen B, Isaacs C, Weber B, Foulkes W, Ainsworth P, Tung N, Eisen A, Friedman E, Eng C, Sun P, Narod SA
Int J Cancer. 2006
PubMed ID: 16032702
Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants.
Lovelock PK, Healey S, Au W, Sum EY, Tesoriero A, Wong EM, Hinson S, Brinkworth R, Bekessy A, Diez O, Izatt L, Solomon E, Jenkins M, Renard H, Hopper J, Waring P, Tavtigian SV, Goldgar D, Lindeman GJ, Visvader JE, Couch FJ, Henderson BR, Southey M, Chenevix-Trench G, Spurdle AB, Brown MA, kConFab Investigators
J Med Genet. 2006
PubMed ID: 15923272
Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers.
Cullinane CA, Lubinski J, Neuhausen SL, Ghadirian P, Lynch HT, Isaacs C, Weber B, Moller P, Offit K, Kim-Sing C, Friedman E, Randall S, Pasini B, Ainsworth P, Gershoni-Baruch R, Foulkes WD, Klijn J, Tung N, Rennert G, Olopade O, Couch F, Wagner T, Olsson H, Sun P, Weitzel JN, Narod SA
Int J Cancer. 2005
PubMed ID: 15986445
BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases.
Pal T, Permuth-Wey J, Betts JA, Krischer JP, Fiorica J, Arango H, LaPolla J, Hoffman M, Martino MA, Wakeley K, Wilbanks G, Nicosia S, Cantor A, Sutphen R
Cancer. 2005
PubMed ID: 16284991
Modulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppression.
Hu Y, Ghosh S, Amleh A, Yue W, Lu Y, Katz A, Li R
Oncogene. 2005
PubMed ID: 16170371
BRCA1 associates with the inactive X chromosome in late S-phase, coupled with transient H2AX phosphorylation.
Chadwick BP, Lane TF
Chromosoma. 2005
PubMed ID: 16240122
The impact of receiving genetic test results on general and cancer-specific psychologic distress among members of an African-American kindred with a BRCA1 mutation.
Kinney AY, Bloor LE, Mandal D, Simonsen SE, Baty BJ, Holubkov R, Seggar K, Neuhausen S, Smith K
Cancer. 2005
PubMed ID: 16222692
[Mutational analysis of BRCA1 and BRCA2 genes in early-onset breast cancer patients in Shanghai]
Song CG, Hu Z, Yuan WT, Di GH, Shen ZZ, Huang W, Shao ZM
Zhonghua Yi Xue Za Zhi. 2005
PubMed ID: 16324400
BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene.
Kennedy RD, Gorski JJ, Quinn JE, Stewart GE, James CR, Moore S, Mulligan K, Emberley ED, Lioe TF, Morrison PJ, Mullan PB, Reid G, Johnston PG, Watson PH, Harkin DP
Cancer Res. 2005
PubMed ID: 16288014
Search for large genomic alterations of the BRCA1 gene in a Finnish population.
Laurila E, Syrjäkoski K, Holli K, Kallioniemi A, Karhu R
Cancer Genet Cytogenet. 2005
PubMed ID: 16271956
High incidence of 4153delA BRCA1 gene mutations in Lithuanian breast- and breast-ovarian cancer families.
Gronwald J, Elsakov P, Górski B, Lubiński J
Breast Cancer Res Treat. 2005
PubMed ID: 16261409
Effect of bilateral oophorectomy on mammary tumor formation in BRCA1 mutant mice.
Bachelier R, Xu X, Li C, Qiao W, Furth PA, Lubet RA, Deng CX
Oncol Rep. 2005
PubMed ID: 16211273
Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene.
Hughes DJ, Ginolhac SM, Coupier I, Barjhoux L, Gaborieau V, Bressac-de-Paillerets B, Chompret A, Bignon YJ, Uhrhammer N, Lasset C, Giraud S, Sobol H, Hardouin A, Berthet P, Peyrat JP, Fournier J, Nogues C, Lidereau R, Muller D, Fricker JP, Longy M, Toulas C, Guimbaud R, Yannoukakos D, Mazoyer S, Lynch HT, Lenoir GM, Goldgar DE, Stoppa-Lyonnet D, Sinilnikova OM
Int J Cancer. 2005
PubMed ID: 15900600
Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: an international case-control study.
Eisen A, Lubinski J, Klijn J, Moller P, Lynch HT, Offit K, Weber B, Rebbeck T, Neuhausen SL, Ghadirian P, Foulkes WD, Gershoni-Baruch R, Friedman E, Rennert G, Wagner T, Isaacs C, Kim-Sing C, Ainsworth P, Sun P, Narod SA
J Clin Oncol. 2005
PubMed ID: 16234515
BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly.
Lin SY, Rai R, Li K, Xu ZX, Elledge SJ
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16217032
A new alternative splice variant of BRCA1 containing an additional in-frame exon.
Fortin J, Moisan AM, Dumont M, Leblanc G, Labrie Y, Durocher F, Bessette P, Bridge P, Chiquette J, Laframboise R, Lépine J, Lespérance B, Pichette R, Plante M, Provencher L, Voyer P, Simard J
Biochim Biophys Acta. 2005
PubMed ID: 16185777
BRCA1 mutations and polymorphisms in a hospital-based consecutive series of breast cancer patients from Apulia, Italy.
Tommasi S, Crapolicchio A, Lacalamita R, Bruno M, Monaco A, Petroni S, Schittulli F, Longo S, Digennaro M, Calistri D, Mangia A, Paradiso A
Mutat Res. 2005
PubMed ID: 16026807
Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage.
Monaco L, Kolthur-Seetharam U, Loury R, Murcia JM, de Murcia G, Sassone-Corsi P
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16179389
Atm heterozygosity cooperates with loss of Brca1 to increase the severity of mammary gland cancer and reduce ductal branching.
Bowen TJ, Yakushiji H, Montagna C, Jain S, Ried T, Wynshaw-Boris A
Cancer Res. 2005
PubMed ID: 16204043
Mutational analysis of the estrogen receptor-alpha gene in familial ovarian cancer.
Wu HJ, Sekine M, Kashima K, Hirai Y, Hatae M, Kobayashi I, Obata K, Enomoto T, Umesaki N, Ushijima K, Tanaka K, Japanese Familial Ovarian Cancer Study Group
J Obstet Gynaecol Res. 2005
PubMed ID: 16176503
Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination.
Sankaran S, Starita LM, Groen AC, Ko MJ, Parvin JD
Mol Cell Biol. 2005
PubMed ID: 16166645
Risk of breast cancer recurrence and contralateral breast cancer in relation to BRCA1 and BRCA2 mutation status following breast-conserving surgery and radiotherapy.
Kirova YM, Stoppa-Lyonnet D, Savignoni A, Sigal-Zafrani B, Fabre N, Fourquet A, for the Institut Curie Breast Cancer Study Group
Eur J Cancer. 2005
PubMed ID: 16140006
Impact of teenage oral contraceptive use in a population-based series of early-onset breast cancer cases who have undergone BRCA mutation testing.
Jernström H, Loman N, Johannsson OT, Borg A, Olsson H
Eur J Cancer. 2005
PubMed ID: 16118051
BRCA1 and BRCA2 as ovarian cancer susceptibility genes.
Sowter HM, Ashworth A
Carcinogenesis. 2005
PubMed ID: 15917310
Male BRCA1 and BRCA2 mutation carriers: a pilot study investigating medical characteristics of patients participating in a prostate cancer prevention clinic.
Horsburgh S, Matthew A, Bristow R, Trachtenberg J
Prostate. 2005
PubMed ID: 15880530
BRCA1 interaction with human papillomavirus oncoproteins.
Zhang Y, Fan S, Meng Q, Ma Y, Katiyar P, Schlegel R, Rosen EM
J Biol Chem. 2005
PubMed ID: 15983032
In vitro platination of human breast cancer suppressor gene1 (BRCA1) by the anticancer drug carboplatin.
Ratanaphan A, Canyuk B, Wasiksiri S, Mahasawat P
Biochim Biophys Acta. 2005
PubMed ID: 16099593
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription.
Jeffy BD, Hockings JK, Kemp MQ, Morgan SS, Hager JA, Beliakoff J, Whitesell LJ, Bowden GT, Romagnolo DF
Neoplasia. 2005
PubMed ID: 16229810
BRCA1 in hormonal carcinogenesis: basic and clinical research.
Rosen EM, Fan S, Isaacs C
Endocr Relat Cancer. 2005
PubMed ID: 16172191
Upregulation of the BRCA1 gene in human germ cells and in preimplantation embryos.
Giscard d'Estaing S, Perrin D, Lenoir GM, Guérin JF, Dante R
Fertil Steril. 2005
PubMed ID: 16169426
The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein.
Zhong X, Liu L, Zhao A, Pfeifer GP, Xu X
Cell Cycle. 2005
PubMed ID: 16123590
Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking.
Henderson BR
Bioessays. 2005
PubMed ID: 16108063
Good timing in the cell cycle for precise DNA repair by BRCA1.
Durant ST, Nickoloff JA
Cell Cycle. 2005
PubMed ID: 16103751
De novo Alu element insertions targeted to a sequence common to the BRCA1 and BRCA2 genes.
Teugels E, De Brakeleer S, Goelen G, Lissens W, Sermijn E, De Grève J
Hum Mutat. 2005
PubMed ID: 16088935
High follicular phase luteinizing hormone levels in young healthy BRCA1 mutation carriers: implications for breast and ovarian cancer risk.
Jernström H, Borg K, Olsson H
Mol Genet Metab. 2005
PubMed ID: 16084122
Prognostic impact of BRCA1 pathogenic and BRCA1/BRCA2 unclassified variant mutations in patients with ovarian carcinoma.
Majdak EJ, Debniak J, Milczek T, Cornelisse CJ, Devilee P, Emerich J, Jassem J, De Bock GH
Cancer. 2005
PubMed ID: 16047333
Identification of two evolutionarily conserved and functional regulatory elements in intron 2 of the human BRCA1 gene.
Wardrop SL, Brown MA, kConFab Investigators
Genomics. 2005
PubMed ID: 15990270
Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex.
Varma AK, Brown RS, Birrane G, Ladias JA
Biochemistry. 2005
PubMed ID: 16101277
A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk.
Freedman ML, Penney KL, Stram DO, Riley S, McKean-Cowdin R, Le Marchand L, Altshuler D, Haiman CA
Cancer Res. 2005
PubMed ID: 16103107
[Population genetic analysis of the association between the BRCA1 and P53 gene polymorphisms and the risk of sporadic breast cancer]
Tarasov VA, Aslanian MM, Tsyrendorzhieva ES, Gar'kavtseva RF, Liubchenko LN, Altukhov IuP, Mel'nik VA
Genetika. 2005
PubMed ID: 16161633
Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity.
Wang C, Fan S, Li Z, Fu M, Rao M, Ma Y, Lisanti MP, Albanese C, Katzenellenbogen BS, Kushner PJ, Weber B, Rosen EM, Pestell RG
Cancer Res. 2005
PubMed ID: 16061635
Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
Kotsopoulos J, Lubinski J, Lynch HT, Neuhausen SL, Ghadirian P, Isaacs C, Weber B, Kim-Sing C, Foulkes WD, Gershoni-Baruch R, Ainsworth P, Friedman E, Daly M, Garber JE, Karlan B, Olopade OI, Tung N, Saal HM, Eisen A, Osborne M, Olsson H, Gilchrist D, Sun P, Narod SA
Cancer Causes Control. 2005
PubMed ID: 16049805
53BP1 is a positive regulator of the BRCA1 promoter.
Rauch T, Zhong X, Pfeifer GP, Xu X
Cell Cycle. 2005
PubMed ID: 15970701
Contribution of BRCA1 and BRCA2 germ-line mutations to the incidence of breast cancer in young women: results from a prospective population-based study in France.
Bonadona V, Sinilnikova OM, Chopin S, Antoniou AC, Mignotte H, Mathevet P, Brémond A, Martin A, Bobin JY, Romestaing P, Raudrant D, Rudigoz RC, Léoné M, Chauvin F, Easton DF, Lenoir GM, Lasset C
Genes Chromosomes Cancer. 2005
PubMed ID: 15887246
Analysis of BRCA1 and BRCA2 mutations in Brazilian breast cancer patients with positive family history.
Dufloth RM, Carvalho S, Heinrich JK, Shinzato JY, dos Santos CC, Zeferino LC, Schmitt F
Sao Paulo Med J. 2005
PubMed ID: 16389418
Prevalence of BRCA mutations and founder effect in high-risk Hispanic families.
Weitzel JN, Lagos V, Blazer KR, Nelson R, Ricker C, Herzog J, McGuire C, Neuhausen S
Cancer Epidemiol Biomarkers Prev. 2005
PubMed ID: 16030099
Breast and ovarian cancer risks to carriers of the BRCA1 5382insC and 185delAG and BRCA2 6174delT mutations: a combined analysis of 22 population based studies.
Antoniou AC, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL, Olsson H, Johannsson O, Borg A, Pasini B, Radice P, Manoukian S, Eccles DM, Tang N, Olah E, Anton-Culver H, Warner E, Lubinski J, Gronwald J, Gorski B, Tulinius H, Thorlacius S, Eerola H, Nevanlinna H, Syrjäkoski K, Kallioniemi OP, Thompson D, Evans C, Peto J, Lalloo F, Evans DG, Easton DF
J Med Genet. 2005
PubMed ID: 15994883
Breast cancer predisposing alleles in Poland.
Górski B, Cybulski C, Huzarski T, Byrski T, Gronwald J, Jakubowska A, Stawicka M, Gozdecka-Grodecka S, Szwiec M, Urbański K, Mituś J, Marczyk E, Dziuba J, Wandzel P, Surdyka D, Haus O, Janiszewska H, Debniak T, Tołoczko-Grabarek A, Medrek K, Masojć B, Mierzejewski M, Kowalska E, Narod SA, Lubiński J
Breast Cancer Res Treat. 2005
PubMed ID: 15980987
Hereditary breast cancer growth rates and its impact on screening policy.
Tilanus-Linthorst MM, Kriege M, Boetes C, Hop WC, Obdeijn IM, Oosterwijk JC, Peterse HL, Zonderland HM, Meijer S, Eggermont AM, de Koning HJ, Klijn JG, Brekelmans CT
Eur J Cancer. 2005
PubMed ID: 15978801
BRCA1 participates in DNA decatenation.
Lou Z, Minter-Dykhouse K, Chen J
Nat Struct Mol Biol. 2005
PubMed ID: 15965487
BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II.
Starita LM, Horwitz AA, Keogh MC, Ishioka C, Parvin JD, Chiba N
J Biol Chem. 2005
PubMed ID: 15886201
Prevalence of five previously reported and recurrent BRCA1 genetic rearrangement mutations in 20,000 patients from hereditary breast/ovarian cancer families.
Hendrickson BC, Judkins T, Ward BD, Eliason K, Deffenbaugh AE, Burbidge LA, Pyne K, Leclair B, Ward BE, Scholl T
Genes Chromosomes Cancer. 2005
PubMed ID: 15846789
Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells.
Furuta S, Jiang X, Gu B, Cheng E, Chen PL, Lee WH
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15967981
The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor alpha.
Wada-Hiraike O, Yano T, Nei T, Matsumoto Y, Nagasaka K, Takizawa S, Oishi H, Arimoto T, Nakagawa S, Yasugi T, Kato S, Taketani Y
Br J Cancer. 2005
PubMed ID: 15886699
An amino-terminal motif functions as a second nuclear export sequence in BRCA1.
Thompson ME, Robinson-Benion CL, Holt JT
J Biol Chem. 2005
PubMed ID: 15811849
Hypersensitivity of Brca1-deficient MEF to the DNA interstrand crosslinking agent mitomycin C is associated with defect in homologous recombination repair and aberrant S-phase arrest.
Yun J, Zhong Q, Kwak JY, Lee WH
Oncogene. 2005
PubMed ID: 15782115
[Molecular alterations in breast cancer: clinical implications and new analytical tools]
Gonçalves A, Viens P, Sobol H, Maraninchi D, Bertucci F
Rev Med Interne. 2005
PubMed ID: 15936476
Placental cadherin and the basal epithelial phenotype of BRCA1-related breast cancer.
Arnes JB, Brunet JS, Stefansson I, Bégin LR, Wong N, Chappuis PO, Akslen LA, Foulkes WD
Clin Cancer Res. 2005
PubMed ID: 15930334
BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.
Kleiman FE, Wu-Baer F, Fonseca D, Kaneko S, Baer R, Manley JL
Genes Dev. 2005
PubMed ID: 15905410
BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation.
Yan Y, Spieker RS, Kim M, Stoeger SM, Cowan KH
Oncogene. 2005
PubMed ID: 15735702
Increased rates of chromosome breakage in BRCA1 carriers are normalized by oral selenium supplementation.
Kowalska E, Narod SA, Huzarski T, Zajaczek S, Huzarska J, Gorski B, Lubinski J
Cancer Epidemiol Biomarkers Prev. 2005
PubMed ID: 15894690
BRCA1 gene expression in breast cancer: a correlative study between real-time RT-PCR and immunohistochemistry.
Al-Mulla F, Abdulrahman M, Varadharaj G, Akhter N, Anim JT
J Histochem Cytochem. 2005
PubMed ID: 15872055
Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations.
Casey MJ, Synder C, Bewtra C, Narod SA, Watson P, Lynch HT
Gynecol Oncol. 2005
PubMed ID: 15863145
Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription.
Batsché E, Moschopoulos P, Desroches J, Bilodeau S, Drouin J
J Biol Chem. 2005
PubMed ID: 15701640
BRCA1 and pancreatic cancer: pedigree findings and their causal relationships.
Lynch HT, Deters CA, Snyder CL, Lynch JF, Villeneuve P, Silberstein J, Martin H, Narod SA, Brand RE
Cancer Genet Cytogenet. 2005
PubMed ID: 15796958
BRCA1: a locus-specific "liaison" in gene expression and genetic integrity.
Aiyar S, Sun JL, Li R
J Cell Biochem. 2005
PubMed ID: 15723343
[Genetic instability on chromosome 17q21 in gastric cancer of Chinese patients]
Lin XQ, Liang Y, Ding SP, Li JC
Shi Yan Sheng Wu Xue Bao. 2005
PubMed ID: 16011248
Mutational analysis of the BRCA1 gene in 30 Czech ovarian cancer patients.
Zikan M, Pohlreich P, Stribrna J
J Genet. 2005
PubMed ID: 15876585
Promoter usage of BRCA1-IRIS.
Elshamy WM, Livingston DM
Nat Cell Biol. 2005
PubMed ID: 15803127
Promoter usage of BRCA1-IRIS.
Kvist A, Rovira C, Borg A, Medstrand P
Nat Cell Biol. 2005
PubMed ID: 15803125
Patients with an unclassified genetic variant in the BRCA1 or BRCA2 genes show different clinical features from those with a mutation.
Gómez-García EB, Ambergen T, Blok MJ, van den Wijngaard A
J Clin Oncol. 2005
PubMed ID: 15800311
Identification of germline BRCA1 and BRCA2 genetic alterations in Greek breast cancer moderate-risk and low-risk individuals--correlation with clinicopathological data.
Kataki A, Gomatos I, Pararas N, Armakolas A, Panousopoulos D, Karantzikos G, Voros D, Zografos G, Markopoulos C, Leandros E, Konstadoulakis M
Clin Genet. 2005
PubMed ID: 15733268
ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis.
Andersen JL, Zimmerman ES, DeHart JL, Murala S, Ardon O, Blackett J, Chen J, Planelles V
Cell Death Differ. 2005
PubMed ID: 15650754
TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage.
Dubrovska A, Kanamoto T, Lomnytska M, Heldin CH, Volodko N, Souchelnytskyi S
Oncogene. 2005
PubMed ID: 15735739
Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells.
Chodankar R, Kwang S, Sangiorgi F, Hong H, Yen HY, Deng C, Pike MC, Shuler CF, Maxson R, Dubeau L
Curr Biol. 2005
PubMed ID: 15797026
Structural determinants of the BRCA1 : estrogen receptor interaction.
Ma YX, Tomita Y, Fan S, Wu K, Tong Y, Zhao Z, Song LN, Goldberg ID, Rosen EM
Oncogene. 2005
PubMed ID: 15674350
BRCA1 gene expression in breast cancer in Kuwait: correlation with prognostic parameters.
Amirrad M, Al-Mulla F, Varadharaj G, John B, Saji T, Anim JT
Med Princ Pract. 2005
PubMed ID: 15785095
Coinheritance of BRCA1 and BRCA2 mutations with Fanconi anemia and Bloom syndrome mutations in Ashkenazi Jewish population: possible role in risk modification for cancer development.
Koren-Michowitz M, Friedman E, Gershoni-Baruch R, Brok-Simoni F, Patael Y, Rechavi G, Amariglio N
Am J Hematol. 2005
PubMed ID: 15726604
Novel somatic mutations in the BRCA1 gene in sporadic breast tumors.
Janatova M, Zikan M, Dundr P, Matous B, Pohlreich P
Hum Mutat. 2005
PubMed ID: 15712267
The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci.
Au WW, Henderson BR
J Biol Chem. 2005
PubMed ID: 15569676
Prevalence of BRCA1 and BRCA2 mutations in women diagnosed with ductal carcinoma in situ.
Claus EB, Petruzella S, Matloff E, Carter D
JAMA. 2005
PubMed ID: 15728167
Oral contraceptive use and risk of early-onset breast cancer in carriers and noncarriers of BRCA1 and BRCA2 mutations.
Milne RL, Knight JA, John EM, Dite GS, Balbuena R, Ziogas A, Andrulis IL, West DW, Li FP, Southey MC, Giles GG, McCredie MR, Hopper JL, Whittemore AS
Cancer Epidemiol Biomarkers Prev. 2005
PubMed ID: 15734957
Phosphorylated BRCA1 is predominantly located in the nucleus and mitochondria.
Coene ED, Hollinshead MS, Waeytens AA, Schelfhout VR, Eechaute WP, Shaw MK, Van Oostveldt PM, Vaux DJ
Mol Biol Cell. 2005
PubMed ID: 15591126
Characterization of segments from the central region of BRCA1: an intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions?
Mark WY, Liao JC, Lu Y, Ayed A, Laister R, Szymczyna B, Chakrabartty A, Arrowsmith CH
J Mol Biol. 2005
PubMed ID: 15571721
Germline BRCA1 mutations and G/C polymorphism in the 5'-untranslated region of the RAD51 gene in Polish women with breast cancer.
Romanowicz-Makowska H, Smolarz B, Kulig A
Pol J Pathol. 2005
PubMed ID: 16477874
BRCA1 and BRCA2 pathways and the risk of cancers other than breast or ovarian.
Friedenson B
MedGenMed. 2005
PubMed ID: 16369438
TP53 mutations in ovarian carcinomas from sporadic cases and carriers of two distinct BRCA1 founder mutations; relation to age at diagnosis and survival.
Kringen P, Wang Y, Dumeaux V, Nesland JM, Kristensen G, Borresen-Dale AL, Dorum A
BMC Cancer. 2005
PubMed ID: 16229746
Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
Kotsopoulos J, Olopado OI, Ghadirian P, Lubinski J, Lynch HT, Isaacs C, Weber B, Kim-Sing C, Ainsworth P, Foulkes WD, Eisen A, Sun P, Narod SA
Breast Cancer Res. 2005
PubMed ID: 16168130
High proportion of recurrent germline mutations in the BRCA1 gene in breast and ovarian cancer patients from the Prague area.
Pohlreich P, Zikan M, Stribrna J, Kleibl Z, Janatova M, Kotlas J, Zidovska J, Novotny J, Petruzelka L, Szabo C, Matous B
Breast Cancer Res. 2005
PubMed ID: 16168118
Familial breast cancer: characteristics and outcome of BRCA 1-2 positive and negative cases.
Veronesi A, de Giacomi C, Magri MD, Lombardi D, Zanetti M, Scuderi C, Dolcetti R, Viel A, Crivellari D, Bidoli E, Boiocchi M
BMC Cancer. 2005
PubMed ID: 15996267
The Tyr978X BRCA1 mutation: occurrence in non-Jewish Iranians and haplotype in French-Canadian and non-Ashkenazi Jews.
Quintana-Murci L, Gal I, Bakhan T, Quach H, Sayar SH, Shiri-Sverdlov R, Baruch RG, McElreavey K, Dagan E, Narod S, Friedman E
Fam Cancer. 2005
PubMed ID: 15951957
High prevalence of two BRCA1 mutations, 4154delA and 5382insC, in Latvia.
Tikhomirova L, Sinicka O, Smite D, Eglitis J, Hodgson SV, Stengrevics A
Fam Cancer. 2005
PubMed ID: 15951956
Use of adenoviral E1A protein to analyze K18 promoter deregulation in colon carcinoma cells discloses a role for CtBP1 and BRCA1.
Delouis C, Prochasson P, Laithier M, Brison O
BMC Mol Biol. 2005
PubMed ID: 15831101
Understanding breast cancer risk -- where do we stand in 2005?
Dumitrescu RG, Cotarla I
J Cell Mol Med. 2005
PubMed ID: 15784178
Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer.
Cox DG, Kraft P, Hankinson SE, Hunter DJ
Breast Cancer Res. 2005
PubMed ID: 15743496
Recent developments in critical genes in the molecular biology of breast cancer.
Sunpaweravong S, Sunpaweravong P
Asian J Surg. 2005
PubMed ID: 15691805
Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2.
Hayami R, Sato K, Wu W, Nishikawa T, Hiroi J, Ohtani-Kaneko R, Fukuda M, Ohta T
Cancer Res. 2005
PubMed ID: 15665273
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Prevalence and clinical correlations of BRCA1/BRCA2 unclassified variant carriers among unselected primary ovarian cancer cases - preliminary report.
Majdak EJ, De Bock GH, Brozek I, Perkowska M, Ochman K, Debniak J, Milczek T, Cornelisse CJ, Jassem J, Emerich J, Limon J, Devilee P
Eur J Cancer. 2005
PubMed ID: 15617999
The risk of ovarian cancer after breast cancer in BRCA1 and BRCA2 carriers.
Metcalfe KA, Lynch HT, Ghadirian P, Tung N, Olivotto IA, Foulkes WD, Warner E, Olopade O, Eisen A, Weber B, McLennan J, Sun P, Narod SA
Gynecol Oncol. 2005
PubMed ID: 15589605
Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1.
Gaiser OJ, Ball LJ, Schmieder P, Leitner D, Strauss H, Wahl M, Kühne R, Oschkinat H, Heinemann U
Biochemistry. 2004
PubMed ID: 15609993
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation.
Turner JM, Aprelikova O, Xu X, Wang R, Kim S, Chandramouli GV, Barrett JC, Burgoyne PS, Deng CX
Curr Biol. 2004
PubMed ID: 15589157
A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint.
Wang RH, Yu H, Deng CX
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15563594
Vascular endothelial growth factor (VEGF) levels and mutation of the BRCA1 gene in breast cancer patients.
Tarnowski B, Chudecka-Głaz A, Górski B, Rzepka-Górska I
Breast Cancer Res Treat. 2004
PubMed ID: 15609132
Prevalence of BRCA1 mutation carriers among U.S. non-Hispanic Whites.
Whittemore AS, Gong G, John EM, McGuire V, Li FP, Ostrow KL, Dicioccio R, Felberg A, West DW
Cancer Epidemiol Biomarkers Prev. 2004
PubMed ID: 15598764
A protein truncating BRCA1 allele with a low penetrance of breast cancer.
Gorski B, Menkiszak J, Gronwald J, Lubinski J, Narod SA
J Med Genet. 2004
PubMed ID: 15591272
Differential association of BRCA1 and BRCA2 genes with some breast cancer-associated genes in early and late onset breast tumors.
Chunder N, Mandal S, Roy A, Roychoudhury S, Panda CK
Ann Surg Oncol. 2004
PubMed ID: 15576832
Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells.
Kondo T, Raff M
Genes Dev. 2004
PubMed ID: 15574597
Negative modulation of androgen receptor transcriptional activity by Daxx.
Lin DY, Fang HI, Ma AH, Huang YS, Pu YS, Jenster G, Kung HJ, Shih HM
Mol Cell Biol. 2004
PubMed ID: 15572661
BRCA2, but not BRCA1, mutations account for familial ovarian cancer in Iceland: a population-based study.
Rafnar T, Benediktsdottir KR, Eldon BJ, Gestsson T, Saemundsson H, Olafsson K, Salvarsdottir A, Steingrimsson E, Thorlacius S
Eur J Cancer. 2004
PubMed ID: 15571962
Oral contraceptive use and ovarian cancer risk among carriers of BRCA1 or BRCA2 mutations.
Whittemore AS, Balise RR, Pharoah PD, Dicioccio RA, Oakley-Girvan I, Ramus SJ, Daly M, Usinowicz MB, Garlinghouse-Jones K, Ponder BA, Buys S, Senie R, Andrulis I, John E, Hopper JL, Piver MS
Br J Cancer. 2004
PubMed ID: 15545966
BRCA1 mutations in ovarian cancer and borderline tumours in Norway: a nested case-control study.
Bjørge T, Lie AK, Hovig E, Gislefoss RE, Hansen S, Jellum E, Langseth H, Nustad K, Tropé CG, Dørum A
Br J Cancer. 2004
PubMed ID: 15477862
[Analysis of BRCA1 mutations in Chinese patients with early onset breast cancer and affected relatives.]
Hu Z, Wu J, Lu JS, Luo JM, Han QX, Shen ZZ, Shao ZM
Zhonghua Zhong Liu Za Zhi. 2004
PubMed ID: 15777502
Novel germline mutations in breast cancer susceptibility genes BRCA1, BRCA2 and p53 gene in breast cancer patients from India.
Hedau S, Jain N, Husain SA, Mandal AK, Ray G, Shahid M, Kant R, Gupta V, Shukla NK, Deo SS, Das BC
Breast Cancer Res Treat. 2004
PubMed ID: 15564800
BRCA1 induces antioxidant gene expression and resistance to oxidative stress.
Bae I, Fan S, Meng Q, Rih JK, Kim HJ, Kang HJ, Xu J, Goldberg ID, Jaiswal AK, Rosen EM
Cancer Res. 2004
PubMed ID: 15520196
A gene-environment interaction between occupation and BRCA1/BRCA2 mutations in male breast cancer?
Palli D, Masala G, Mariani-Costantini R, Zanna I, Saieva C, Sera F, Decarli A, Ottini L
Eur J Cancer. 2004
PubMed ID: 15519522
Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1.
Kim SS, Cao L, Li C, Xu X, Huber LJ, Chodosh LA, Deng CX
Mol Cell Biol. 2004
PubMed ID: 15485917
Genetic steps of mammalian homologous repair with distinct mutagenic consequences.
Stark JM, Pierce AJ, Oh J, Pastink A, Jasin M
Mol Cell Biol. 2004
PubMed ID: 15485900
Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation.
Zimmerman ES, Chen J, Andersen JL, Ardon O, Dehart JL, Blackett J, Choudhary SK, Camerini D, Nghiem P, Planelles V
Mol Cell Biol. 2004
PubMed ID: 15485898
1H, 13C and 15N resonance assignments of the C-terminal BRCT domain from human BRCA1.
Gaiser OJ, Oschkinat H, Heinemann U, Ball LJ
J Biomol NMR. 2004
PubMed ID: 15557806
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.
Zhang X, Succi J, Feng Z, Prithivirajsingh S, Story MD, Legerski RJ
Mol Cell Biol. 2004
PubMed ID: 15456891
Identification of BRCA1-IRIS, a BRCA1 locus product.
ElShamy WM, Livingston DM
Nat Cell Biol. 2004
PubMed ID: 15448696
Relation of contraceptive and reproductive history to ovarian cancer risk in carriers and noncarriers of BRCA1 gene mutations.
McGuire V, Felberg A, Mills M, Ostrow KL, DiCioccio R, John EM, West DW, Whittemore AS
Am J Epidemiol. 2004
PubMed ID: 15383404
BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number.
Starita LM, Machida Y, Sankaran S, Elias JE, Griffin K, Schlegel BP, Gygi SP, Parvin JD
Mol Cell Biol. 2004
PubMed ID: 15367667
BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer.
Seo JH, Cho DY, Ahn SH, Yoon KS, Kang CS, Cho HM, Lee HS, Choe JJ, Choi CW, Kim BS, Shin SW, Kim YH, Kim JS, Son GS, Lee JB, Koo BH
Hum Mutat. 2004
PubMed ID: 15365993
Truncating BRCA1 mutations are uncommon in a cohort of hereditary prostate cancer families with evidence of linkage to 17q markers.
Zuhlke KA, Madeoy JJ, Beebe-Dimmer J, White KA, Griffin A, Lange EM, Gruber SB, Ostrander EA, Cooney KA
Clin Cancer Res. 2004
PubMed ID: 15447980
Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination.
Warner E, Plewes DB, Hill KA, Causer PA, Zubovits JT, Jong RA, Cutrara MR, DeBoer G, Yaffe MJ, Messner SJ, Meschino WS, Piron CA, Narod SA
JAMA. 2004
PubMed ID: 15367553
The effects of BRCA1 missense variants V1804D and M1628T on transcriptional activity.
Ostrow KL, McGuire V, Whittemore AS, DiCioccio RA
Cancer Genet Cytogenet. 2004
PubMed ID: 15350310
BRCA1 and BRCA2 mutations as prognostic factors in bilateral breast cancer patients.
Rogozińska-Szczepka J, Utracka-Hutka B, Grzybowska E, Maka B, Nowicka E, Smok-Ragankiewicz A, Zientek H, Steffen J, Wojciechowska-Łacka A
Ann Oncol. 2004
PubMed ID: 15319244
RNA analysis reveals splicing mutations and loss of expression defects in MLH1 and BRCA1.
Sharp A, Pichert G, Lucassen A, Eccles D
Hum Mutat. 2004
PubMed ID: 15300854
ERBB2, TBX2, RPS6KB1, and MYC alterations in breast tissues of BRCA1 and BRCA2 mutation carriers.
Adem C, Soderberg CL, Hafner K, Reynolds C, Slezak JM, Sinclair CS, Sellers TA, Schaid DJ, Couch F, Hartmann LC, Jenkins RB
Genes Chromosomes Cancer. 2004
PubMed ID: 15236312
BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention.
Fabbro M, Schuechner S, Au WW, Henderson BR
Exp Cell Res. 2004
PubMed ID: 15265711
Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1.
Xu X, Lee J, Stern DF
J Biol Chem. 2004
PubMed ID: 15220350
Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression.
Choudhury AD, Xu H, Baer R
J Biol Chem. 2004
PubMed ID: 15166217
BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220.
Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S
Oncogene. 2004
PubMed ID: 15208681
Predictors of cognitive appraisals following genetic testing for BRCA1 and BRCA2 mutations.
Halbert CH, Schwartz MD, Wenzel L, Narod S, Peshkin BN, Cella D, Lerman C
J Behav Med. 2004
PubMed ID: 15559734
Association study of candidate genes for the prevalence and progression of knee osteoarthritis.
Valdes AM, Hart DJ, Jones KA, Surdulescu G, Swarbrick P, Doyle DV, Schafer AJ, Spector TD
Arthritis Rheum. 2004
PubMed ID: 15334463
Determination of hereditary mutations in the BRCA1 gene using archived serum samples and capillary electrophoresis.
Ekstrøm PO, Bjørge T, Dørum A, Longva AS, Heintz KM, Warren DJ, Hansen S, Gislefoss RE, Hovig E
Anal Chem. 2004
PubMed ID: 15283579
BRCA1 can modulate RNA polymerase II carboxy-terminal domain phosphorylation levels.
Moisan A, Larochelle C, Guillemette B, Gaudreau L
Mol Cell Biol. 2004
PubMed ID: 15282296
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function.
Arlt MF, Xu B, Durkin SG, Casper AM, Kastan MB, Glover TW
Mol Cell Biol. 2004
PubMed ID: 15254237
BRCA1 185delAG mutation inhibits Akt-dependent, IAP-mediated caspase 3 inactivation in human ovarian surface epithelial cells.
Johnson NC, Dan HC, Cheng JQ, Kruk PA
Exp Cell Res. 2004
PubMed ID: 15242757
Accommodating risk: responses to BRCA1/2 genetic testing of women who have had cancer.
Hallowell N, Foster C, Eeles R, Ardern-Jones A, Watson M
Soc Sci Med. 2004
PubMed ID: 15144764
BRCA1 and sex ratio.
Struewing JP, Hartge P, Wacholder S, Tucker MA, Greene MH
Eur J Hum Genet. 2004
PubMed ID: 15114373
Expression of an amino-terminal BRCA1 deletion mutant causes a dominant growth inhibition in MCF10A cells.
You F, Chiba N, Ishioka C, Parvin JD
Oncogene. 2004
PubMed ID: 15122325
Effect of a computer-based decision aid on knowledge, perceptions, and intentions about genetic testing for breast cancer susceptibility: a randomized controlled trial.
Green MJ, Peterson SK, Baker MW, Harper GR, Friedman LC, Rubinstein WS, Mauger DT
JAMA. 2004
PubMed ID: 15280342
Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase.
Sato K, Hayami R, Wu W, Nishikawa T, Nishikawa H, Okuda Y, Ogata H, Fukuda M, Ohta T
J Biol Chem. 2004
PubMed ID: 15184379
BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.
Fabbro M, Savage K, Hobson K, Deans AJ, Powell SN, McArthur GA, Khanna KK
J Biol Chem. 2004
PubMed ID: 15159397
Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
Jernström H, Lubinski J, Lynch HT, Ghadirian P, Neuhausen S, Isaacs C, Weber BL, Horsman D, Rosen B, Foulkes WD, Friedman E, Gershoni-Baruch R, Ainsworth P, Daly M, Garber J, Olsson H, Sun P, Narod SA
J Natl Cancer Inst. 2004
PubMed ID: 15265971
The variant E233G of the RAD51D gene could be a low-penetrance allele in high-risk breast cancer families without BRCA1/2 mutations.
Rodríguez-López R, Osorio A, Ribas G, Pollán M, Sánchez-Pulido L, de la Hoya M, Ruibal A, Zamora P, Arias JI, Salazar R, Vega A, Martínez JI, Esteban-Cardeñosa E, Alonso C, Letón R, Urioste Azcorra M, Miner C, Armengod ME, Carracedo A, González-Sarmiento R, Caldés T, Díez O, Benítez J
Int J Cancer. 2004
PubMed ID: 15170666
Breast cancer risk and the DNA double-strand break end-joining capacity of nonhomologous end-joining genes are affected by BRCA1.
Bau DT, Fu YP, Chen ST, Cheng TC, Yu JC, Wu PE, Shen CY
Cancer Res. 2004
PubMed ID: 15256476
Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation.
Hamatani T, Daikoku T, Wang H, Matsumoto H, Carter MG, Ko MS, Dey SK
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15232000
Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure.
Wang X, Wang RH, Li W, Xu X, Hollander MC, Fornace AJ, Deng CX
J Biol Chem. 2004
PubMed ID: 15123655
BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II.
Cabart P, Chew HK, Murphy S
Oncogene. 2004
PubMed ID: 15107825
DNA damage induces p53-dependent BRCA1 nuclear export.
Feng Z, Kachnic L, Zhang J, Powell SN, Xia F
J Biol Chem. 2004
PubMed ID: 15087457
Cancer genetics knowledge and beliefs and receipt of results in Ashkenazi Jewish individuals receiving counseling for BRCA1/2 mutations.
Kelly K, Leventhal H, Marvin M, Toppmeyer D, Baran J, Schwalb M
Cancer Control. 2004
PubMed ID: 15284715
Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains.
Botuyan MV, Nominé Y, Yu X, Juranic N, Macura S, Chen J, Mer G
Structure. 2004
PubMed ID: 15242590
BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer.
Razandi M, Pedram A, Rosen EM, Levin ER
Mol Cell Biol. 2004
PubMed ID: 15199145
VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice.
Le Cras TD, Spitzmiller RE, Albertine KH, Greenberg JM, Whitsett JA, Akeson AL
Am J Physiol Lung Cell Mol Physiol. 2004
PubMed ID: 15033636
Smoking and the risk of breast cancer among carriers of BRCA mutations.
Ghadirian P, Lubinski J, Lynch H, Neuhausen SL, Weber B, Isaacs C, Baruch RG, Randall S, Ainsworth P, Friedman E, Freidman E, Horsman D, Tonin P, Foulkes WD, Tung N, Sun P, Narod SA
Int J Cancer. 2004
PubMed ID: 15095307
BRCA1 interacts with and is required for paclitaxel-induced activation of mitogen-activated protein kinase kinase kinase 3.
Gilmore PM, McCabe N, Quinn JE, Kennedy RD, Gorski JJ, Andrews HN, McWilliams S, Carty M, Mullan PB, Duprex WP, Liu ET, Johnston PG, Harkin DP
Cancer Res. 2004
PubMed ID: 15205325
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.
Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB
Genes Dev. 2004
PubMed ID: 15175241
Down-regulation of BRCA1 in chronic pancreatitis and sporadic pancreatic adenocarcinoma.
Beger C, Ramadani M, Meyer S, Leder G, Krüger M, Welte K, Gansauge F, Beger HG
Clin Cancer Res. 2004
PubMed ID: 15173085
Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.
Williams RS, Lee MS, Hau DD, Glover JN
Nat Struct Mol Biol. 2004
PubMed ID: 15133503
Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer.
Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, Smerdon SJ
Nat Struct Mol Biol. 2004
PubMed ID: 15133502
Offspring gender ratio and the rate of recurrent spontaneous miscarriages in jewish women at high risk for breast/ovarian cancer.
Gal I, Sadetzki S, Gershoni-Baruch R, Oberman B, Carp H, Papa MZ, Diestelman-Menachem T, Eisenberg-Barzilai S, Friedman E
Am J Hum Genet. 2004
PubMed ID: 15116316
A single-nucleotide polymorphism in the RAD51 gene modifies breast cancer risk in BRCA2 carriers, but not in BRCA1 carriers or noncarriers.
Kadouri L, Kote-Jarai Z, Hubert A, Durocher F, Abeliovich D, Glaser B, Hamburger T, Eeles RA, Peretz T
Br J Cancer. 2004
PubMed ID: 15138485
Association of NQO1 polymorphism with spontaneous breast cancer in two independent populations.
Menzel HJ, Sarmanova J, Soucek P, Berberich R, Grünewald K, Haun M, Kraft HG
Br J Cancer. 2004
PubMed ID: 15138483
Collaboration of Brca1 and Chk2 in tumorigenesis.
McPherson JP, Lemmers B, Hirao A, Hakem A, Abraham J, Migon E, Matysiak-Zablocki E, Tamblyn L, Sanchez-Sweatman O, Khokha R, Squire J, Hande MP, Mak TW, Hakem R
Genes Dev. 2004
PubMed ID: 15131084
Impact of BRCA1/BRCA2 counseling and testing on newly diagnosed breast cancer patients.
Schwartz MD, Lerman C, Brogan B, Peshkin BN, Halbert CH, DeMarco T, Lawrence W, Main D, Finch C, Magnant C, Pennanen M, Tsangaris T, Willey S, Isaacs C
J Clin Oncol. 2004
PubMed ID: 15067026
Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.
Shiozaki EN, Gu L, Yan N, Shi Y
Mol Cell. 2004
PubMed ID: 15125843
BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition.
Ouchi M, Fujiuchi N, Sasai K, Katayama H, Minamishima YA, Ongusaha PP, Deng C, Sen S, Lee SW, Ouchi T
J Biol Chem. 2004
PubMed ID: 14990569
Predictors of participation in psychosocial telephone counseling following genetic testing for BRCA1 and BRCA2 mutations.
Halbert CH, Wenzel L, Lerman C, Peshkin BN, Narod S, Marcus A, Corio C, Demarco T, Bellamy S
Cancer Epidemiol Biomarkers Prev. 2004
PubMed ID: 15159322
High-throughput association testing on DNA pools to identify genetic variants that confer susceptibility to acute myeloid leukemia.
Rollinson S, Allan JM, Law GR, Roddam PL, Smith MT, Skibola C, Smith AG, Forrest MS, Sibley K, Higuchi R, Germer S, Morgan GJ
Cancer Epidemiol Biomarkers Prev. 2004
PubMed ID: 15159312
BRCA mutations and risk of prostate cancer in Ashkenazi Jews.
Kirchhoff T, Kauff ND, Mitra N, Nafa K, Huang H, Palmer C, Gulati T, Wadsworth E, Donat S, Robson ME, Ellis NA, Offit K
Clin Cancer Res. 2004
PubMed ID: 15131025
Incidence of BRCA1 and BRCA2 mutations in young Korean breast cancer patients.
Choi DH, Lee MH, Bale AE, Carter D, Haffty BG
J Clin Oncol. 2004
PubMed ID: 15117986
Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis.
Cabanes A, Wang M, Olivo S, DeAssis S, Gustafsson JA, Khan G, Hilakivi-Clarke L
Carcinogenesis. 2004
PubMed ID: 14729590
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation.
Lin SY, Li K, Stewart GS, Elledge SJ
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15096610
Clinical outcome of prophylactic oophorectomy in BRCA1/BRCA2 mutation carriers and events during follow-up.
Olivier RI, van Beurden M, Lubsen MA, Rookus MA, Mooij TM, van de Vijver MJ, van't Veer LJ
Br J Cancer. 2004
PubMed ID: 15083174
BRCA1 IVS2-2delA: a deleterious mutation in a family of Asian descent.
Martin ES, Croce CM, Biggs DD, Martin SE
Cancer Genet Cytogenet. 2004
PubMed ID: 15066328
BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair.
Morris JR, Solomon E
Hum Mol Genet. 2004
PubMed ID: 14976165
Prevalence of BRCA1 and BRCA2 mutations in Korean breast cancer patients.
Ahn SH, Hwang UK, Kwak BS, Yoon HS, Ku BK, Kang HJ, Kim JS, Ko BK, Ko CD, Yoon KS, Cho DY, Kim JS, Son BH
J Korean Med Sci. 2004
PubMed ID: 15082902
Pathology of ovarian cancers in BRCA1 and BRCA2 carriers.
Lakhani SR, Manek S, Penault-Llorca F, Flanagan A, Arnout L, Merrett S, McGuffog L, Steele D, Devilee P, Klijn JG, Meijers-Heijboer H, Radice P, Pilotti S, Nevanlinna H, Butzow R, Sobol H, Jacquemier J, Lyonet DS, Neuhausen SL, Weber B, Wagner T, Winqvist R, Bignon YJ, Monti F, Schmitt F, Lenoir G, Seitz S, Hamman U, Pharoah P, Lane G, Ponder B, Bishop DT, Easton DF
Clin Cancer Res. 2004
PubMed ID: 15073127
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2.
Hill DA, de la Serna IL, Veal TM, Imbalzano AN
J Cell Biochem. 2004
PubMed ID: 15034933
BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families.
Claes K, Poppe B, Coene I, Paepe AD, Messiaen L
Br J Cancer. 2004
PubMed ID: 15026808
Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type.
Foulkes WD, Metcalfe K, Sun P, Hanna WM, Lynch HT, Ghadirian P, Tung N, Olopade OI, Weber BL, McLennan J, Olivotto IA, Bégin LR, Narod SA
Clin Cancer Res. 2004
PubMed ID: 15041722
Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes.
Sigurdson AJ, Hauptmann M, Chatterjee N, Alexander BH, Doody MM, Rutter JL, Struewing JP
BMC Cancer. 2004
PubMed ID: 15113441
Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1.
Rodriguez JA, Schüchner S, Au WW, Fabbro M, Henderson BR
Oncogene. 2004
PubMed ID: 14647430
Analyses of p53 expression pattern and BRCA mutations in patients with double primary breast and ovarian cancer.
Bruchim I, Fishman A, Friedman E, Goldberg I, Chetrit A, Barshack I, Dekel E, Hirsh-Yechezkel G, Modan B, Kopolovic J
Int J Gynecol Cancer. 2004
PubMed ID: 15086724
Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis.
Ekblad CM, Friedler A, Veprintsev D, Weinberg RL, Itzhaki LS
Protein Sci. 2004
PubMed ID: 14978302
Germ-line mutations in BRCA1 or BRCA2 in the normal breast are associated with altered expression of estrogen-responsive proteins and the predominance of progesterone receptor A.
Mote PA, Leary JA, Avery KA, Sandelin K, Chenevix-Trench G, Kirk JA, Clarke CL, kConFab Investigators
Genes Chromosomes Cancer. 2004
PubMed ID: 14732925
Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression.
Tan W, Zheng L, Lee WH, Boyer TG
J Biol Chem. 2004
PubMed ID: 14660588
[Germline mutations in the BRCA1 and BRCA2 genes from breast cancer families in China Han people]
Zhou YZ, Sun Q, Lin SQ, Wang J, Liu B, Li JX, Zhou YD, Ye J, Han H, Fang FD
Zhonghua Yi Xue Za Zhi. 2004
PubMed ID: 15059511
Ovarian cancer and polymorphisms in the androgen and progesterone receptor genes: a HuGE review.
Modugno F
Am J Epidemiol. 2004
PubMed ID: 14769635
Screening adherence in BRCA1/2 families is associated with primary physicians' behavior.
Tinley ST, Houfek J, Watson P, Wenzel L, Clark MB, Coughlin S, Lynch HT
Am J Med Genet A. 2004
PubMed ID: 14755459
Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase.
Nishikawa H, Ooka S, Sato K, Arima K, Okamoto J, Klevit RE, Fukuda M, Ohta T
J Biol Chem. 2004
PubMed ID: 14638690
Brca1 expression is regulated by a bidirectional promoter that is shared by the Nbr1 gene in mouse.
Whitehouse C, Chambers J, Catteau A, Solomon E
Gene. 2004
PubMed ID: 14729266
Loss of heterozygosity in normal breast epithelial tissue and benign breast lesions in BRCA1/2 carriers with breast cancer.
Cavalli LR, Singh B, Isaacs C, Dickson RB, Haddad BR
Cancer Genet Cytogenet. 2004
PubMed ID: 15104281
Downregulation of BRCA1 in A375 melanoma cell line increases radio-sensitivity and modifies metastatic and angiogenic gene expression.
Hesling C, D'Incan M, D'Incan C, Souteyrand P, Monboisse JC, Pasco S, Madelmont JC, Bignon YJ
J Invest Dermatol. 2004
PubMed ID: 15009718
BRCA1 and BRCA2 mutations in women from Shanghai China.
Suter NM, Ray RM, Hu YW, Lin MG, Porter P, Gao DL, Zaucha RE, Iwasaki LM, Sabacan LP, Langlois MC, Thomas DB, Ostrander EA
Cancer Epidemiol Biomarkers Prev. 2004
PubMed ID: 14973102
Survival and recurrence after breast cancer in BRCA1/2 mutation carriers.
El-Tamer M, Russo D, Troxel A, Bernardino LP, Mazziotta R, Estabrook A, Ditkoff BA, Schnabel F, Mansukhani M
Ann Surg Oncol. 2004
PubMed ID: 14761918
One in 10 ovarian cancer patients carry germ line BRCA1 or BRCA2 mutations: results of a prospective study in Southern Sweden.
Malander S, Ridderheim M, Måsbäck A, Loman N, Kristoffersson U, Olsson H, Nilbert M, Borg A
Eur J Cancer. 2004
PubMed ID: 14746861
Impact of BRCA1/2 testing and disclosure of a positive test result on women affected and unaffected with breast or ovarian cancer.
van Roosmalen MS, Stalmeier PF, Verhoef LC, Hoekstra-Weebers JE, Oosterwijk JC, Hoogerbrugge N, Moog U, van Daal WA
Am J Med Genet A. 2004
PubMed ID: 14735581
Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain.
Rodriguez JA, Au WW, Henderson BR
Exp Cell Res. 2004
PubMed ID: 14729053
Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families.
Valarmathi MT, Sawhney M, Deo SS, Shukla NK, Das SN
Hum Mutat. 2004
PubMed ID: 14722926
Association of BRCA1 with the inactive X chromosome and XIST RNA.
Ganesan S, Silver DP, Drapkin R, Greenberg R, Feunteun J, Livingston DM
Philos Trans R Soc Lond B Biol Sci. 2004
PubMed ID: 15065664
Fidelity of DNA double-strand break repair in heterozygous cell lines harbouring BRCA1 missense mutations.
Coupier I, Baldeyron C, Rousseau A, Mosseri V, Pages-Berhouet S, Caux-Moncoutier V, Papadopoulo D, Stoppa-Lyonnet D
Oncogene. 2004
PubMed ID: 14647443
Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival.
Marsit CJ, Liu M, Nelson HH, Posner M, Suzuki M, Kelsey KT
Oncogene. 2004
PubMed ID: 14647419
Randomised trial of a decision aid and its timing for women being tested for a BRCA1/2 mutation.
van Roosmalen MS, Stalmeier PF, Verhoef LC, Hoekstra-Weebers JE, Oosterwijk JC, Hoogerbrugge N, Moog U, van Daal WA
Br J Cancer. 2004
PubMed ID: 14735173
Polyglutamine repeat length in the AIB1 gene modifies breast cancer susceptibility in BRCA1 carriers.
Kadouri L, Kote-Jarai Z, Easton DF, Hubert A, Hamoudi R, Glaser B, Abeliovich D, Peretz T, Eeles RA
Int J Cancer. 2004
PubMed ID: 14648706
MYC is amplified in BRCA1-associated breast cancers.
Grushko TA, Dignam JJ, Das S, Blackwood AM, Perou CM, Ridderstråle KK, Anderson KN, Wei MJ, Adams AJ, Hagos FG, Sveen L, Lynch HT, Weber BL, Olopade OI
Clin Cancer Res. 2004
PubMed ID: 14760071
Frequency of BRCA1 and BRCA2 mutations in unselected Ashkenazi Jewish patients with colorectal cancer.
Kirchhoff T, Satagopan JM, Kauff ND, Huang H, Kolachana P, Palmer C, Rapaport H, Nafa K, Ellis NA, Offit K
J Natl Cancer Inst. 2004
PubMed ID: 14709740
BRCA1 and BRCA2 founder mutations and the risk of colorectal cancer.
Niell BL, Rennert G, Bonner JD, Almog R, Tomsho LP, Gruber SB
J Natl Cancer Inst. 2004
PubMed ID: 14709734
[A paradox and three egnimas about the role of BRCA1 in breast and ovarian cancers]
Feunteun J
J Soc Biol. 2004
PubMed ID: 15368961
Characterization of two novel BRCA1 germ-line mutations involving splice donor sites.
Brose MS, Volpe P, Paul K, Stopfer JE, Colligon TA, Calzone KA, Weber BL
Genet Test. 2004
PubMed ID: 15345110
BRCA1 mutations in a population-based study of breast cancer in Stockholm County.
Margolin S, Werelius B, Fornander T, Lindblom A
Genet Test. 2004
PubMed ID: 15345109
The presence of hereditary BRCA1 gene mutations in women with familial breast or ovarian cancer and the frequency of occurrence of these tumours in their relatives.
Skasko E, Paszko Z, Niwińska A, Kwiatkowska E, Kruczek A, Pieńkowski T
Eur J Gynaecol Oncol. 2004
PubMed ID: 15285306
Awareness of breast cancer genetics and interest in predictive genetic testing: a survey of a southern Italian population.
Bruno M, Tommasi S, Stea B, Quaranta M, Schittulli F, Mastropasqua A, Distante A, Di Paola L, Paradiso A
Ann Oncol. 2004
PubMed ID: 15280188
Frequency of the ATM IVS10-6T-->G variant in Australian multiple-case breast cancer families.
Lindeman GJ, Hiew M, Visvader JE, Leary J, Field M, Gaff CL, Gardner RJ, Trainor K, Cheetham G, Suthers G, Kirk J
Breast Cancer Res. 2004
PubMed ID: 15217508
Generation and analysis of Brca1 conditional knockout mice.
Deng CX, Xu X
Methods Mol Biol. 2004
PubMed ID: 15187254
Identification and evaluation of 55 genetic variations in the BRCA1 and the BRCA2 genes of patients from 50 Japanese breast cancer families.
Kawahara M, Sakayori M, Shiraishi K, Nomizu T, Takeda M, Abe R, Ohuchi N, Takenoshita S, Ishioka C
J Hum Genet. 2004
PubMed ID: 15168169
Non-uptake of predictive genetic testing for BRCA1/2 among relatives of known carriers: attributes, cancer worry, and barriers to testing in a multicenter clinical cohort.
Foster C, Evans DG, Eeles R, Eccles D, Ashley S, Brooks L, Cole T, Cook J, Davidson R, Gregory H, Mackay J, Morrison PJ, Watson M
Genet Test. 2004
PubMed ID: 15140371
Diagnostic genetic testing for hereditary breast and ovarian cancer in cancer patients: women's looking back on the pre-test period and a psychological evaluation.
Claes E, Evers-Kiebooms G, Boogaerts A, Decruyenaere M, Denayer L, Legius E
Genet Test. 2004
PubMed ID: 15140370
An audit of screening for familial breast cancer before 50 years in the South Thames Region - have we got it right?
Murday V, Pears R, Ball J, Eeles R, Hodgson S
Fam Cancer. 2004
PubMed ID: 15131403
BRCA1 testing in breast and/or ovarian cancer families from northeastern France identifies two common mutations with a founder effect.
Muller D, Bonaiti-Pellié C, Abecassis J, Stoppa-Lyonnet D, Fricker JP
Fam Cancer. 2004
PubMed ID: 15131401
The 1100delAT BRCA1 and the 8765delAG BRCA2 mutations: occurrence in high-risk non-Ashkenazi Jews and haplotype comparison of Jewish and non-Jewish carriers.
Gal I, Gershoni Baruch R, Haber D, Dagan E, Eisenberg-Barzilai S, Zidan J, Friedman E
Fam Cancer. 2004
PubMed ID: 15131400
Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study.
Bernstein JL, Langholz B, Haile RW, Bernstein L, Thomas DC, Stovall M, Malone KE, Lynch CF, Olsen JH, Anton-Culver H, Shore RE, Boice JD, Berkowitz GS, Gatti RA, Teitelbaum SL, Smith SA, Rosenstein BS, Børresen-Dale AL, Concannon P, Thompson WD, WECARE study
Breast Cancer Res. 2004
PubMed ID: 15084244
Clinical features of familial ovarian cancer lacking mutations in BRCA1 or BRCA2.
Menkiszak J, Gronwald J, Górski B, Byrski T, Huzarski T, Jakubowska A, Foszczyńska-Kłoda M, Brzosko M, Fliciński J, Rzepka-Górska I, Narod SA, Lubiński J
Eur J Gynaecol Oncol. 2004
PubMed ID: 15053073
Attitudes toward preventive oophorectomy among BRCA1 mutation carriers in Poland.
Menkiszak J, Rzepka-Górska I, Górski B, Gronwald J, Byrski T, Huzarski T, Jakubowska A, Metcalfe KA, Narod SA, Lubiński J
Eur J Gynaecol Oncol. 2004
PubMed ID: 15053071
Efficacy of risk-reducing salpingo-oophorectomy in women with BRCA-1 and BRCA-2 mutations.
Olopade OI, Artioli G
Breast J. 2004
PubMed ID: 14984481
Mutation analysis of the breast cancer gene BRCA1 among breast cancer Jordanian females.
Atoum MF, Al-Kayed SA
Saudi Med J. 2004
PubMed ID: 14758382
Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.
Zhang J, Willers H, Feng Z, Ghosh JC, Kim S, Weaver DT, Chung JH, Powell SN, Xia F
Mol Cell Biol. 2004
PubMed ID: 14701743
A combined analysis of outcome following breast cancer: differences in survival based on BRCA1/BRCA2 mutation status and administration of adjuvant treatment.
Robson ME, Chappuis PO, Satagopan J, Wong N, Boyd J, Goffin JR, Hudis C, Roberge D, Norton L, Bégin LR, Offit K, Foulkes WD
Breast Cancer Res. 2004
PubMed ID: 14680495
Atypical epithelial proliferation in fallopian tubes in prophylactic salpingo-oophorectomy specimens from BRCA1 and BRCA2 germline mutation carriers.
Carcangiu ML, Radice P, Manoukian S, Spatti G, Gobbo M, Pensotti V, Crucianelli R, Pasini B
Int J Gynecol Pathol. 2004
PubMed ID: 14668548
Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.
Rodriguez M, Yu X, Chen J, Songyang Z
J Biol Chem. 2003
PubMed ID: 14578343
Detection of protein folding defects caused by BRCA1-BRCT truncation and missense mutations.
Williams RS, Chasman DI, Hau DD, Hui B, Lau AY, Glover JN
J Biol Chem. 2003
PubMed ID: 14534301
BRCA1 associates with processive RNA polymerase II.
Krum SA, Miranda GA, Lin C, Lane TF
J Biol Chem. 2003
PubMed ID: 14506230
TP53, BRCA1, and BRCA2 tumor suppressor genes are not commonly mutated in survivors of Hodgkin's disease with second primary neoplasms.
Nichols KE, Heath JA, Friedman D, Biegel JA, Ganguly A, Mauch P, Diller L
J Clin Oncol. 2003
PubMed ID: 14673037
Repression of mRNA for the PLK cell cycle gene after DNA damage requires BRCA1.
Ree AH, Bratland A, Nome RV, Stokke T, Fodstad Ø
Oncogene. 2003
PubMed ID: 14654792
A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.
Aglipay JA, Lee SW, Okada S, Fujiuchi N, Ohtsuka T, Kwak JC, Wang Y, Johnstone RW, Deng C, Qin J, Ouchi T
Oncogene. 2003
PubMed ID: 14654789
[Isolation and characterization of a BRCA1-interacting protein]
Yan JH, Ye QN, Zhu JH, Zhong HJ, Zheng HY, Huang CF
Yi Chuan Xue Bao. 2003
PubMed ID: 14986435
The CHEK2*1100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families.
Oldenburg RA, Kroeze-Jansema K, Kraan J, Morreau H, Klijn JG, Hoogerbrugge N, Ligtenberg MJ, van Asperen CJ, Vasen HF, Meijers C, Meijers-Heijboer H, de Bock TH, Cornelisse CJ, Devilee P
Cancer Res. 2003
PubMed ID: 14678969
Effect of genetic cancer risk assessment on surgical decisions at breast cancer diagnosis.
Weitzel JN, McCaffrey SM, Nedelcu R, MacDonald DJ, Blazer KR, Cullinane CA
Arch Surg. 2003
PubMed ID: 14662532
BRCA1 inhibition of telomerase activity in cultured cells.
Xiong J, Fan S, Meng Q, Schramm L, Wang C, Bouzahza B, Zhou J, Zafonte B, Goldberg ID, Haddad BR, Pestell RG, Rosen EM
Mol Cell Biol. 2003
PubMed ID: 14612409
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Fallopian tube and primary peritoneal carcinomas associated with BRCA mutations.
Levine DA, Argenta PA, Yee CJ, Marshall DS, Olvera N, Bogomolniy F, Rahaman JA, Robson ME, Offit K, Barakat RR, Soslow RA, Boyd J
J Clin Oncol. 2003
PubMed ID: 14615451
Functional and physical interactions between BRCA1 and p53 in transcriptional regulation of the IGF-IR gene.
Abramovitch S, Werner H
Horm Metab Res. 2003
PubMed ID: 14710355
Enhanced sensitivity of peripheral blood lymphocytes from women carrying a BRCA1 mutation towards the mutagenic effects of various cytostatics.
Trenz K, Lugowski S, Jahrsdörfer U, Jainta S, Vogel W, Speit G
Mutat Res. 2003
PubMed ID: 14644329
Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.
Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R
Mol Cell. 2003
PubMed ID: 14636569
Bilateral prophylactic oophorectomy and ovarian cancer screening following BRCA1/BRCA2 mutation testing.
Schwartz MD, Kaufman E, Peshkin BN, Isaacs C, Hughes C, DeMarco T, Finch C, Lerman C
J Clin Oncol. 2003
PubMed ID: 14581427
BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks.
Westermark UK, Reyngold M, Olshen AB, Baer R, Jasin M, Moynahan ME
Mol Cell Biol. 2003
PubMed ID: 14560035
Mutational analysis of BRCA1 and BRCA2 in Mediterranean Spanish women with early-onset breast cancer: identification of three novel pathogenic mutations.
Martínez-Ferrandis JI, Vega A, Chirivella I, Marín-García P, Insa A, Lluch A, Carracedo A, Chaves FJ, García-Conde J, Cervantes A, Armengod ME
Hum Mutat. 2003
PubMed ID: 14517958
BRCA1 and p53: compensatory roles in DNA repair.
Hartman AR, Ford JM
J Mol Med. 2003
PubMed ID: 13679996
Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2.
King MC, Marks JH, Mandell JB, New York Breast Cancer Study Group
Science. 2003
PubMed ID: 14576434
The BRCT domain is a phospho-protein binding domain.
Yu X, Chini CC, He M, Mer G, Chen J
Science. 2003
PubMed ID: 14576433
BRCT repeats as phosphopeptide-binding modules involved in protein targeting.
Manke IA, Lowery DM, Nguyen A, Yaffe MB
Science. 2003
PubMed ID: 14576432
E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9.
Oberley MJ, Inman DR, Farnham PJ
J Biol Chem. 2003
PubMed ID: 12909625
Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas.
Sutherland KD, Visvader JE, Choong DY, Sum EY, Lindeman GJ, Campbell IG
Int J Cancer. 2003
PubMed ID: 12925972
Long-term psychological impact of carrying a BRCA1/2 mutation and prophylactic surgery: a 5-year follow-up study.
van Oostrom I, Meijers-Heijboer H, Lodder LN, Duivenvoorden HJ, van Gool AR, Seynaeve C, van der Meer CA, Klijn JG, van Geel BN, Burger CW, Wladimiroff JW, Tibben A
J Clin Oncol. 2003
PubMed ID: 14551306
Of mice and (wo)men: genotype-phenotype correlations in BRCA1.
Hohenstein P, Fodde R
Hum Mol Genet. 2003
PubMed ID: 12915453
Hereditary ovarian cancer in Poland.
Menkiszak J, Gronwald J, Górski B, Jakubowska A, Huzarski T, Byrski T, Foszczyńska-Kłoda M, Haus O, Janiszewska H, Perkowska M, Brozek I, Grzybowska E, Zientek H, Góźdź S, Kozak-Klonowska B, Urbański K, Miturski R, Kowalczyk J, Pluzańska A, Niepsuj S, Koc J, Szwiec M, Drosik K, Mackiewicz A, Lamperska K, Strózyk E, Godlewski D, Stawicka M, Waśko B, Bebenek M, Rozmiarek A, Rzepka-Górska I, Narod SA, Lubiński J
Int J Cancer. 2003
PubMed ID: 12918074
BRCA1 interacts with FHL2 and enhances FHL2 transactivation function.
Yan J, Zhu J, Zhong H, Lu Q, Huang C, Ye Q
FEBS Lett. 2003
PubMed ID: 14550570
The role of the breast cancer susceptibility gene 1 (BRCA1) in sporadic epithelial ovarian cancer.
McCoy ML, Mueller CR, Roskelley CD
Reprod Biol Endocrinol. 2003
PubMed ID: 14613551
Awareness and concern about ovarian cancer among women at risk because of a family history of breast or ovarian cancer.
Andersen MR, Bowen D, Yasui Y, McTiernan A
Am J Obstet Gynecol. 2003
PubMed ID: 14586320
Sociocultural influences on participation in genetic risk assessment and testing among African American women.
Hughes C, Fasaye GA, LaSalle VH, Finch C
Patient Educ Couns. 2003
PubMed ID: 14572939
BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis.
Quinn JE, Kennedy RD, Mullan PB, Gilmore PM, Carty M, Johnston PG, Harkin DP
Cancer Res. 2003
PubMed ID: 14559807
Polymorphisms in BRCA1 and BRCA2 and risk of epithelial ovarian cancer.
Wenham RM, Schildkraut JM, McLean K, Calingaert B, Bentley RC, Marks J, Berchuck A
Clin Cancer Res. 2003
PubMed ID: 14555511
The Norwegian founder mutations in BRCA1: high penetrance confirmed in an incident cancer series and differences observed in the risk of ovarian cancer.
Heimdal K, Maehle L, Apold J, Pedersen JC, Møller P
Eur J Cancer. 2003
PubMed ID: 14522380
Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer.
Foulkes WD, Stefansson IM, Chappuis PO, Bégin LR, Goffin JR, Wong N, Trudel M, Akslen LA
J Natl Cancer Inst. 2003
PubMed ID: 14519755
BRCA1 in hormone-responsive cancers.
Rosen EM, Fan S, Pestell RG, Goldberg ID
Trends Endocrinol Metab. 2003
PubMed ID: 14516936
Novel consensus DNA-binding sequence for BRCA1 protein complexes.
Cable PL, Wilson CA, Calzone FJ, Rauscher FJ, Scully R, Livingston DM, Li L, Blackwell CB, Futreal PA, Afshari CA
Mol Carcinog. 2003
PubMed ID: 14502648
Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.
Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA
Exp Cell Res. 2003
PubMed ID: 14499622
Analysis of BRCA1 and BRCA2 genes in Spanish breast/ovarian cancer patients: a high proportion of mutations unique to Spain and evidence of founder effects.
Díez O, Osorio A, Durán M, Martinez-Ferrandis JI, de la Hoya M, Salazar R, Vega A, Campos B, Rodríguez-López R, Velasco E, Chaves J, Díaz-Rubio E, Jesús Cruz J, Torres M, Esteban E, Cervantes A, Alonso C, San Román JM, González-Sarmiento R, Miner C, Carracedo A, Eugenia Armengod M, Caldés T, Benítez J, Baiget M
Hum Mutat. 2003
PubMed ID: 12955716
Identification and characterization of NIF3L1 BP1, a novel cytoplasmic interaction partner of the NIF3L1 protein.
Tascou S, Kang TW, Trappe R, Engel W, Burfeind P
Biochem Biophys Res Commun. 2003
PubMed ID: 12951069
siRNA depletion of BRCA1, but not BRCA2, causes increased genome instability in Fanconi anemia cells.
Bruun D, Folias A, Akkari Y, Cox Y, Olson S, Moses R
DNA Repair (Amst). 2003
PubMed ID: 12967657
The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin.
Wu-Baer F, Lagrazon K, Yuan W, Baer R
J Biol Chem. 2003
PubMed ID: 12890688
Prevalence of BRCA1 and BRCA2 germline mutations in young breast cancer patients: a population-based study.
de Sanjosé S, Léoné M, Bérez V, Izquierdo A, Font R, Brunet JM, Louat T, Vilardell L, Borras J, Viladiu P, Bosch FX, Lenoir GM, Sinilnikova OM
Int J Cancer. 2003
PubMed ID: 12845657
Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity.
Krum SA, Womack JE, Lane TF
Oncogene. 2003
PubMed ID: 12955082
Defect of tumour necrosis factor-alpha (TNF-alpha) production and TNF-alpha-induced ICAM-1-expression in BRCA1 mutations carriers.
Zielinski CC, Budinsky AC, Wagner TM, Wolfram RM, Köstler WJ, Kubista M, Brodowicz T, Kubista E, Wiltschke C
Breast Cancer Res Treat. 2003
PubMed ID: 14572152
Twenty-three novel BRCA1 and BRCA2 sequence alterations in breast and/or ovarian cancer families in Southern Germany.
Meyer P, Voigtlaender T, Bartram CR, Klaes R
Hum Mutat. 2003
PubMed ID: 12938098
Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability.
Spiro C, McMurray CT
Mol Cell Biol. 2003
PubMed ID: 12917330
Aberrant splicing induced by missense mutations in BRCA1: clues from a humanized mouse model.
Yang Y, Swaminathan S, Martin BK, Sharan SK
Hum Mol Genet. 2003
PubMed ID: 12915465
Rad52 gene mutations in breast/ovarian cancer families and sporadic ovarian carcinoma patients.
Tong D, Volm T, Eberhardt E, Krainer M, Leodolter S, Kreienberg R, Zeillinger R
Oncol Rep. 2003
PubMed ID: 12883740
Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues.
Berton TR, Matsumoto T, Page A, Conti CJ, Deng CX, Jorcano JL, Johnson DG
Oncogene. 2003
PubMed ID: 12934101
Association between BRCA1 mutations and ratio of female to male births in offspring of families with breast cancer, ovarian cancer, or both.
de la Hoya M, Fernández JM, Tosar A, Godino J, Sánchez de Abajo A, Vidart JA, Pérez-Segura P, Díaz-Rubio E, Caldés T
JAMA. 2003
PubMed ID: 12928470
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia.
Wong JC, Alon N, Mckerlie C, Huang JR, Meyn MS, Buchwald M
Hum Mol Genet. 2003
PubMed ID: 12913077
Founder mutations in BRCA1/2 are not frequent in Canadian Ashkenazi Jewish men with prostate cancer.
Hamel N, Kotar K, Foulkes WD
BMC Med Genet. 2003
PubMed ID: 12911837
BRCA1 and BRCA2 mutations have no major role in predisposition to prostate cancer in Finland.
Ikonen T, Matikainen MP, Syrjäkoski K, Mononen N, Koivisto PA, Rökman A, Seppälä EH, Kallioniemi OP, Tammela TL, Schleutker J
J Med Genet. 2003
PubMed ID: 12920090
Emerging roles of BRCA1 alternative splicing.
Orban TI, Olah E
Mol Pathol. 2003
PubMed ID: 12890739
Identification of germline 185delAG BRCA1 mutations in non-Jewish Americans of Spanish ancestry from the San Luis Valley, Colorado.
Mullineaux LG, Castellano TM, Shaw J, Axell L, Wood ME, Diab S, Klein C, Sitarik M, Deffenbaugh AM, Graw SL
Cancer. 2003
PubMed ID: 12879478
Founder mutation in the BRCA1 gene in Malay breast cancer patients from Singapore.
Lee AS, Ho GH, Oh PC, Balram C, Ooi LL, Lim DT, Wong CY, Hong GS
Hum Mutat. 2003
PubMed ID: 12872263
Life insurance and breast cancer risk assessment: adverse selection, genetic testing decisions, and discrimination.
Armstrong K, Weber B, FitzGerald G, Hershey JC, Pauly MV, Lemaire J, Subramanian K, Asch DA
Am J Med Genet A. 2003
PubMed ID: 12838555
BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit.
Benezra M, Chevallier N, Morrison DJ, MacLachlan TK, El-Deiry WS, Licht JD
J Biol Chem. 2003
PubMed ID: 12700228
Gynecologic surgeries and risk of ovarian cancer in women with BRCA1 and BRCA2 Ashkenazi founder mutations: an Israeli population-based case-control study.
Rutter JL, Wacholder S, Chetrit A, Lubin F, Menczer J, Ebbers S, Tucker MA, Struewing JP, Hartge P
J Natl Cancer Inst. 2003
PubMed ID: 12865453
BRCA1, BRCA2 and CHEK2 (1100 del C) germline mutations in hereditary breast and ovarian cancer families in South India.
Rajkumar T, Soumittra N, Nancy NK, Swaminathan R, Sridevi V, Shanta V
Asian Pac J Cancer Prev. 2003
PubMed ID: 14507240
P53 codon 72 polymorphism and BRCA 1 and 2 mutations in ovarian epithelial malignancies in black South Africans.
Pegoraro RJ, Moodley M, Rom L, Chetty R, Moodley J
Int J Gynecol Cancer. 2003
PubMed ID: 12911720
BRCA1-independent ubiquitination of FANCD2.
Vandenberg CJ, Gergely F, Ong CY, Pace P, Mallery DL, Hiom K, Patel KJ
Mol Cell. 2003
PubMed ID: 12887909
Attitudes, knowledge, risk perceptions and decision-making among women with breast and/or ovarian cancer considering testing for BRCA1 and BRCA2 and their spouses.
Bluman LG, Rimer BK, Regan Sterba K, Lancaster J, Clark S, Borstelmann N, Iglehart JD, Winer EP
Psychooncology. 2003
PubMed ID: 12833555
Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability.
McCarthy EE, Celebi JT, Baer R, Ludwig T
Mol Cell Biol. 2003
PubMed ID: 12832489
The analysis of BRCA1 mutations in eastern Chinese patients with early onset breast cancer and affected relatives.
Hu Z, Wu J, Liu CH, Lu JS, Luo JM, Han QX, Shen ZZ, Shao ZM
Hum Mutat. 2003
PubMed ID: 12815604
A specific GFP expression assay, penetrance estimate, and histological assessment for a putative splice site mutation in BRCA1.
Southey MC, Tesoriero A, Young MA, Holloway AJ, Jenkins MA, Whitty J, Misfud S, kConFab, McLachlan SA, Venter DJ, Armes JE
Hum Mutat. 2003
PubMed ID: 12815598
BRCA1 gene in breast cancer.
Rosen EM, Fan S, Pestell RG, Goldberg ID
J Cell Physiol. 2003
PubMed ID: 12767038
Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint.
Yamane K, Chen J, Kinsella TJ
Cancer Res. 2003
PubMed ID: 12810625
BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest.
Ongusaha PP, Ouchi T, Kim KT, Nytko E, Kwak JC, Duda RB, Deng CX, Lee SW
Oncogene. 2003
PubMed ID: 12802282
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.
Foray N, Marot D, Gabriel A, Randrianarison V, Carr AM, Perricaudet M, Ashworth A, Jeggo P
EMBO J. 2003
PubMed ID: 12773400
Reproductive factors and ovarian cancer risk in Jewish BRCA1 and BRCA2 mutation carriers (United States).
Modugno F, Moslehi R, Ness RB, Nelson DB, Belle S, Kant JA, Wheeler JE, Wonderlick A, Fishman D, Karlan B, Risch H, Cramer DW, Dube MP, Narod SA
Cancer Causes Control. 2003
PubMed ID: 12946038
Population attributes affecting the prevalence of BRCA mutation carriers in epithelial ovarian cancer cases in israel.
Hirsh-Yechezkel G, Chetrit A, Lubin F, Friedman E, Peretz T, Gershoni R, Rizel S, Struewing JP, Modan B
Gynecol Oncol. 2003
PubMed ID: 12798717
Similar contributions of BRCA1 and BRCA2 germline mutations to early-onset breast cancer in Germany.
Hamann U, Liu X, Bungardt N, Ulmer HU, Bastert G, Sinn HP
Eur J Hum Genet. 2003
PubMed ID: 12774040
Production of knockout rats using ENU mutagenesis and a yeast-based screening assay.
Zan Y, Haag JD, Chen KS, Shepel LA, Wigington D, Wang YR, Hu R, Lopez-Guajardo CC, Brose HL, Porter KI, Leonard RA, Hitt AA, Schommer SL, Elegbede AF, Gould MN
Nat Biotechnol. 2003
PubMed ID: 12754522
Regulation of BRCA1 transcription by specific single-stranded DNA binding factors.
Thakur S, Nakamura T, Calin G, Russo A, Tamburrino JF, Shimizu M, Baldassarre G, Battista S, Fusco A, Wassell RP, Dubois G, Alder H, Croce CM
Mol Cell Biol. 2003
PubMed ID: 12748281
BRCA1 mutations.
DiCioccio RA, Werness BA, Piver MS
Genes Chromosomes Cancer. 2003
PubMed ID: 12696073
Down-regulation of BRCA1 in BCR-ABL-expressing hematopoietic cells.
Deutsch E, Jarrousse S, Buet D, Dugray A, Bonnet ML, Vozenin-Brotons MC, Guilhot F, Turhan AG, Feunteun J, Bourhis J
Blood. 2003
PubMed ID: 12576338
Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter.
Baker KM, Wei G, Schaffner AE, Ostrowski MC
J Biol Chem. 2003
PubMed ID: 12637547
Effects of spouses on distress experienced by BRCA1 mutation carriers over time.
Wylie JE, Smith KR, Botkin JR
Am J Med Genet C Semin Med Genet. 2003
PubMed ID: 12704636
Communication of BRCA1 and BRCA2 results to at-risk relatives: a cancer risk assessment program's experience.
Wagner Costalas J, Itzen M, Malick J, Babb JS, Bove B, Godwin AK, Daly MB
Am J Med Genet C Semin Med Genet. 2003
PubMed ID: 12704633
Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome.
Narayan G, Arias-Pulido H, Koul S, Vargas H, Zhang FF, Villella J, Schneider A, Terry MB, Mansukhani M, Murty VV
Mol Cancer. 2003
PubMed ID: 12773202
Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex.
Brzovic PS, Keeffe JR, Nishikawa H, Miyamoto K, Fox D, Fukuda M, Ohta T, Klevit R
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12732733
Androgen pathway dysregulation in BRCA1-mutated breast tumors.
Berns EM, Dirkzwager-Kiel MJ, Kuenen-Boumeester V, Timmermans M, Verhoog LC, van den Ouweland AM, Meijer-Heijboer H, Klijn JG, van der Kwast TH
Breast Cancer Res Treat. 2003
PubMed ID: 12779088
Localization of BRCA1 protein in human breast cancer cells.
Chambon M, Nirdé P, Gleizes M, Roger P, Vignon F
Breast Cancer Res Treat. 2003
PubMed ID: 12779087
Breast cancer risk reduction associated with the RAD51 polymorphism among carriers of the BRCA1 5382insC mutation in Poland.
Jakubowska A, Narod SA, Goldgar DE, Mierzejewski M, Masojć B, Nej K, Huzarska J, Byrski T, Górski B, Lubiński J
Cancer Epidemiol Biomarkers Prev. 2003
PubMed ID: 12750242
Improved survival in women with BRCA-associated ovarian carcinoma.
Cass I, Baldwin RL, Varkey T, Moslehi R, Narod SA, Karlan BY
Cancer. 2003
PubMed ID: 12712470
BRCA proteins and DNA damage checkpoints.
Lou Z, Chen J
Front Biosci. 2003
PubMed ID: 12700125
The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cells.
Fedier A, Steiner RA, Schwarz VA, Lenherr L, Haller U, Fink D
Int J Oncol. 2003
PubMed ID: 12684687
BRCA1 splice variants exhibit overlapping and distinct transcriptional transactivation activities.
McEachern KA, Archey WB, Douville K, Arrick BA
J Cell Biochem. 2003
PubMed ID: 12682913
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.
Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL, Loman N, Olsson H, Johannsson O, Borg A, Pasini B, Radice P, Manoukian S, Eccles DM, Tang N, Olah E, Anton-Culver H, Warner E, Lubinski J, Gronwald J, Gorski B, Tulinius H, Thorlacius S, Eerola H, Nevanlinna H, Syrjäkoski K, Kallioniemi OP, Thompson D, Evans C, Peto J, Lalloo F, Evans DG, Easton DF
Am J Hum Genet. 2003
PubMed ID: 12677558
Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice.
Xu X, Aprelikova O, Moens P, Deng CX, Furth PA
Development. 2003
PubMed ID: 12642502
BRCA1-Sp1 interactions in transcriptional regulation of the IGF-IR gene.
Abramovitch S, Glaser T, Ouchi T, Werner H
FEBS Lett. 2003
PubMed ID: 12706836
BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells.
Tassone P, Tagliaferri P, Perricelli A, Blotta S, Quaresima B, Martelli ML, Goel A, Barbieri V, Costanzo F, Boland CR, Venuta S
Br J Cancer. 2003
PubMed ID: 12698198
A role for BRCA1 in sporadic breast cancer.
Fraser JA, Reeves JR, Stanton PD, Black DM, Going JJ, Cooke TG, Bartlett JM
Br J Cancer. 2003
PubMed ID: 12698194
BRCA1 and BRCA2 mutations in Scotland and Northern Ireland.
Scottish/Northern Irish BRCAI/BRCA2 Consortium
Br J Cancer. 2003
PubMed ID: 12698193
Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control.
Lou Z, Chini CC, Minter-Dykhouse K, Chen J
J Biol Chem. 2003
PubMed ID: 12611903
Breast cancer gene 1 (BRCA1): role in cell cycle regulation and DNA repair--perhaps through transcription.
Somasundaram K
J Cell Biochem. 2003
PubMed ID: 12647291
Balancing autonomy and responsibility: the ethics of generating and disclosing genetic information.
Hallowell N, Foster C, Eeles R, Ardern-Jones A, Murday V, Watson M
J Med Ethics. 2003
PubMed ID: 12672886
Roles of BRCA1 in DNA damage repair: a link between development and cancer.
Deng CX, Wang RH
Hum Mol Genet. 2003
PubMed ID: 12668603
Germline mutations in the BRCA1 and BRCA2 genes in Turkish breast/ovarian cancer patients.
Manguoglu AE, Lüleci G, Ozçelik T, Colak T, Schayek H, Akaydin M, Friedman E
Hum Mutat. 2003
PubMed ID: 12655560
Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma.
Baldassarre G, Battista S, Belletti B, Thakur S, Pentimalli F, Trapasso F, Fedele M, Pierantoni G, Croce CM, Fusco A
Mol Cell Biol. 2003
PubMed ID: 12640109
Inhibition of human telomerase reverse transcriptase gene expression by BRCA1 in human ovarian cancer cells.
Zhou C, Liu J
Biochem Biophys Res Commun. 2003
PubMed ID: 12646176
Familial risks, early-onset breast cancer, and BRCA1 and BRCA2 germline mutations.
Dite GS, Jenkins MA, Southey MC, Hocking JS, Giles GG, McCredie MR, Venter DJ, Hopper JL
J Natl Cancer Inst. 2003
PubMed ID: 12644538
Tumor suppressor gene BRCA-1 is expressed by embryonic and adult neural stem cells and involved in cell proliferation.
Korhonen L, Brännvall K, Skoglösa Y, Lindholm D
J Neurosci Res. 2003
PubMed ID: 12605402
Early adoption of BRCA1/2 testing: who and why.
Armstrong K, Weiner J, Weber B, Asch DA
Genet Med. 2003
PubMed ID: 12644778
Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.
Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H
Mol Cell Biol. 2003
PubMed ID: 12612062
Family history of breast and ovarian cancer and the risk of breast carcinoma in situ.
Claus EB, Stowe M, Carter D
Breast Cancer Res Treat. 2003
PubMed ID: 12611452
Early use of clinical BRCA1/2 testing: associations with race and breast cancer risk.
Armstrong K, Weber B, Stopfer J, Calzone K, Putt M, Coyne J, Schwartz JS
Am J Med Genet A. 2003
PubMed ID: 12567413
Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene.
Hohenstein P, Molenaar L, Elsinga J, Morreau H, van der Klift H, Struijk A, Jagmohan-Changur S, Smits R, van Kranen H, van Ommen GJ, Cornelisse C, Devilee P, Fodde R
Genes Chromosomes Cancer. 2003
PubMed ID: 12557227
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ
Nature. 2003
PubMed ID: 12607005
Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells.
Schlegel BP, Starita LM, Parvin JD
Oncogene. 2003
PubMed ID: 12592385
Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein.
Xia Y, Pao GM, Chen HW, Verma IM, Hunter T
J Biol Chem. 2003
PubMed ID: 12431996
Understanding missense mutations in the BRCA1 gene: an evolutionary approach.
Fleming MA, Potter JD, Ramirez CJ, Ostrander GK, Ostrander EA
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12531920
BRCA1 wild-type allele modifies risk of ovarian cancer in carriers of BRCA1 germ-line mutations.
Ginolhac SM, Gad S, Corbex M, Bressac-De-Paillerets B, Chompret A, Bignon YJ, Peyrat JP, Fournier J, Lasset C, Giraud S, Muller D, Fricker JP, Hardouin A, Berthet P, Maugard C, Nogues C, Lidereau R, Longy M, Olschwang S, Toulas C, Guimbaud R, Yannoukakos D, Szabo C, Durocher F, Moisan AM, Simard J, Mazoyer S, Lynch HT, Goldgar D, Stoppa-Lyonnet D, Lenoir GM, Sinilnikova OM
Cancer Epidemiol Biomarkers Prev. 2003
PubMed ID: 12582017
Mutation analysis of BrCA1, BrCA2, and p53 versus soluble HLA class I and class II in a case of familial endometriosis.
Goumenou AG, Vassiliadis S, Matalliotakis IM, Koumantakis EG, Lembessis P, Koutsilieris M
Fertil Steril. 2003
PubMed ID: 12568865
Impact of germline BRCA1 mutations and overexpression of p53 on prognosis and response to treatment following breast carcinoma: 10-year follow up data.
Goffin JR, Chappuis PO, Bégin LR, Wong N, Brunet JS, Hamel N, Paradis AJ, Boyd J, Foulkes WD
Cancer. 2003
PubMed ID: 12548593
Normal lymphocyte development and thymic lymphoma formation in Brca1 exon-11-deficient mice.
Bachelier R, Xu X, Wang X, Li W, Naramura M, Gu H, Deng CX
Oncogene. 2003
PubMed ID: 12555066
Structural consequences of a cancer-causing BRCA1-BRCT missense mutation.
Williams RS, Glover JN
J Biol Chem. 2003
PubMed ID: 12427738
Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization.
Okada S, Ouchi T
J Biol Chem. 2003
PubMed ID: 12427729
BRCA1 and BRCA2 mutation status and tumor characteristics in male breast cancer: a population-based study in Italy.
Ottini L, Masala G, D'Amico C, Mancini B, Saieva C, Aceto G, Gestri D, Vezzosi V, Falchetti M, De Marco M, Paglierani M, Cama A, Bianchi S, Mariani-Costantini R, Palli D
Cancer Res. 2003
PubMed ID: 12543786
Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform.
Cao L, Li W, Kim S, Brodie SG, Deng CX
Genes Dev. 2003
PubMed ID: 12533509
Role of BRCA1 in heat shock response.
Xian Ma Y, Fan S, Xiong J, Yuan RQ, Meng Q, Gao M, Goldberg ID, Fuqua SA, Pestell RG, Rosen EM
Oncogene. 2003
PubMed ID: 12527903
BRCA1/2 mutation carriers: living with susceptibility.
Hagoel L, Neter E, Dishon S, Barnett O, Rennert G
Community Genet. 2003
PubMed ID: 15331870
Log odds of carrying an Ancestral Mutation in BRCA1 or BRCA2 for a Defined personal and family history in an Ashkenazi Jewish woman (LAMBDA).
Apicella C, Andrews L, Hodgson SV, Fisher SA, Lewis CM, Solomon E, Tucker K, Friedlander M, Bankier A, Southey MC, Venter DJ, Hopper JL
Breast Cancer Res. 2003
PubMed ID: 14580256
Cancer incidence in relatives of a population-based set of cases of early-onset breast cancer with a known BRCA1 and BRCA2 mutation status.
Loman N, Bladström A, Johannsson O, Borg A, Olsson H
Breast Cancer Res. 2003
PubMed ID: 14580253
Histopathological characteristics of BRCA1- and BRCA2-associated intraperitoneal cancer: a clinic-based study.
Piek JM, Torrenga B, Hermsen B, Verheijen RH, Zweemer RP, Gille JJ, Kenemans P, van Diest PJ, Menko FH
Fam Cancer. 2003
PubMed ID: 14574155
Detection of the most frequent mutations in BRCA1 gene on polyacrylamide gels containing Spreadex Polymer NAB.
Janatová M, Pohlreich P, Matous B
Neoplasma. 2003
PubMed ID: 12937835
A mutation analysis of the BRCA1 gene in 140 families from southeast France with a history of breast and/or ovarian cancer.
Rostagno P, Gioanni J, Garino E, Vallino P, Namer M, Frenay M
J Hum Genet. 2003
PubMed ID: 12827452
Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population.
Lee JK, Kim HT, Cho SM, Kim KH, Jin HJ, Ryu GM, Oh B, Park C, Kimm K, Jo SA, Jung SC, Kim S, In SM, Lee JE, Jo I
J Hum Genet. 2003
PubMed ID: 12768436
BRCA1 and BRCA2 germline mutations in lymphoma patients.
Yossepowitch O, Olvera N, Satagopan JM, Huang H, Jhanwar S, Rapaport B, Boyd J, Offit K
Leuk Lymphoma. 2003
PubMed ID: 12691152
Mutational screening of breast cancer susceptibility gene 1 from early onset, bi-lateral, and familial breast cancer patients in Taiwan.
Chen ST, Chen RA, Kuo SJ, Chien YC
Breast Cancer Res Treat. 2003
PubMed ID: 12602912
Mouse Wnt9b transforming activity, tissue-specific expression, and evolution.
Qian J, Jiang Z, Li M, Heaphy P, Liu YH, Shackleford GM
Genomics. 2003
PubMed ID: 12573259
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.
Miralem T, Avraham HK
Mol Cell Biol. 2003
PubMed ID: 12509456
Frequency of BRCA mutations in primary peritoneal carcinoma in Israeli Jewish women.
Menczer J, Chetrit A, Barda G, Lubin F, Fishler Y, Altaras M, Levavi H, Struewing JP, Sadetzki S, Modan B
Gynecol Oncol. 2003
PubMed ID: 12504628
BRCA1 germline mutations in Indian familial breast cancer.
Valarmathi MT, A A, Deo SS, Shukla NK, Das SN
Hum Mutat. 2003
PubMed ID: 12497638
Communication with close and distant relatives in the context of genetic testing for hereditary breast and ovarian cancer in cancer patients.
Claes E, Evers-Kiebooms G, Boogaerts A, Decruyenaere M, Denayer L, Legius E
Am J Med Genet A. 2003
PubMed ID: 12476445
Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene.
Edwards SM, Kote-Jarai Z, Meitz J, Hamoudi R, Hope Q, Osin P, Jackson R, Southgate C, Singh R, Falconer A, Dearnaley DP, Ardern-Jones A, Murkin A, Dowe A, Kelly J, Williams S, Oram R, Stevens M, Teare DM, Ponder BA, Gayther SA, Easton DF, Eeles RA, Cancer Research UK/Bristish Prostate Group UK Familial Prostate Cancer Study Collaborators, British Association of Urological Surgeons Section of Oncology
Am J Hum Genet. 2003
PubMed ID: 12474142
Establishing a control population to screen for the occurrence of nineteen unclassified variants in the BRCA1 gene by denaturing high-performance liquid chromatography.
Arnold N, Peper H, Bandick K, Kreikemeier M, Karow D, Teegen B, Jonat W
J Chromatogr B Analyt Technol Biomed Life Sci. 2002
PubMed ID: 12457999
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains.
Mallery DL, Vandenberg CJ, Hiom K
EMBO J. 2002
PubMed ID: 12485996
The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans.
Moynahan ME
Oncogene. 2002
PubMed ID: 12483515
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
Narod SA, Dubé MP, Klijn J, Lubinski J, Lynch HT, Ghadirian P, Provencher D, Heimdal K, Moller P, Robson M, Offit K, Isaacs C, Weber B, Friedman E, Gershoni-Baruch R, Rennert G, Pasini B, Wagner T, Daly M, Garber JE, Neuhausen SL, Ainsworth P, Olsson H, Evans G, Osborne M, Couch F, Foulkes WD, Warner E, Kim-Sing C, Olopade O, Tung N, Saal HM, Weitzel J, Merajver S, Gauthier-Villars M, Jernstrom H, Sun P, Brunet JS
J Natl Cancer Inst. 2002
PubMed ID: 12464649
BRCA1 and BRCA2 bind Stat5a and suppress its transcriptional activity.
Vidarsson H, Mikaelsdottir EK, Rafnar T, Bertwistle D, Ashworth A, Eyfjord JE, Valgeirsdottir S
FEBS Lett. 2002
PubMed ID: 12459499
Frequent loss of BRCA1 nuclear expression in young women with breast cancer: an immunohistochemical study from an area of low incidence but early onset.
Lee WY
Appl Immunohistochem Mol Morphol. 2002
PubMed ID: 12607598
Psychosocial predictors of BRCA counseling and testing decisions among urban African-American women.
Thompson HS, Valdimarsdottir HB, Duteau-Buck C, Guevarra J, Bovbjerg DH, Richmond-Avellaneda C, Amarel D, Godfrey D, Brown K, Offit K
Cancer Epidemiol Biomarkers Prev. 2002
PubMed ID: 12496047
Evaluation of the needs of spouses of female carriers of mutations in BRCA1 and BRCA2.
Metcalfe KA, Liede A, Trinkaus M, Hanna D, Narod SA
Clin Genet. 2002
PubMed ID: 12485194
BRCA1 mutation screening using restriction endonuclease fingerprinting-single-strand conformation polymorphism in an automated capillary electrophoresis system.
Kringen P, Egedal S, Pedersen JC, Harbitz TB, Tveit KM, Berg K, Børresen-Dale AL, Andersen TI
Electrophoresis. 2002
PubMed ID: 12481264
Ovarian cancer risk in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations.
Satagopan JM, Boyd J, Kauff ND, Robson M, Scheuer L, Narod S, Offit K
Clin Cancer Res. 2002
PubMed ID: 12473589
The relationship between the roles of BRCA genes in DNA repair and cancer predisposition.
Tutt A, Ashworth A
Trends Mol Med. 2002
PubMed ID: 12470990
Brca1 and differentiation.
Kubista M, Rosner M, Miloloza A, Hofer K, Prusa AR, Kroiss R, Marton E, Hengstschläger M
Mutat Res. 2002
PubMed ID: 12464350
BRCA1 and BRCA2 germline mutations in Sardinian breast cancer families and their implications for genetic counseling.
Palmieri G, Palomba G, Cossu A, Pisano M, Dedola MF, Sarobba MG, Farris A, Olmeo N, Contu A, Pasca A, Satta MP, Persico I, Carboni AA, Cossu-Rocca P, Contini M, Mangion J, Stratton MR, Tanda F
Ann Oncol. 2002
PubMed ID: 12453858
BRCA1 and BRCA2 mutation analysis of early-onset and familial breast cancer cases in Mexico.
Ruiz-Flores P, Sinilnikova OM, Badzioch M, Calderon-Garcidueñas AL, Chopin S, Fabrice O, González-Guerrero JF, Szabo C, Lenoir G, Goldgar DE, Barrera-Saldaña HA
Hum Mutat. 2002
PubMed ID: 12442275
BRCA1 and BRCA2 sequence variants in Chinese breast cancer families.
Zhi X, Szabo C, Chopin S, Suter N, Wang QS, Ostrander EA, Sinilnikova OM, Lenoir GM, Goldgar D, Shi YR
Hum Mutat. 2002
PubMed ID: 12442274
BRCA1 and BRCA2 in Indian breast cancer patients.
Saxena S, Szabo CI, Chopin S, Barjhoux L, Sinilnikova O, Lenoir G, Goldgar DE, Bhatanager D
Hum Mutat. 2002
PubMed ID: 12442273
Control of biochemical reactions through supramolecular RING domain self-assembly.
Kentsis A, Gordon RE, Borden KL
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12438698
Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha.
Liu Y, Virshup DM, White RL, Hsu LC
Cancer Res. 2002
PubMed ID: 12438214
BRCA1/2 genetic testing in the community setting.
Chen WY, Garber JE, Higham S, Schneider KA, Davis KB, Deffenbaugh AM, Frank TS, Gelman RS, Li FP
J Clin Oncol. 2002
PubMed ID: 12431973
53BP1, a mediator of the DNA damage checkpoint.
Wang B, Matsuoka S, Carpenter PB, Elledge SJ
Science. 2002
PubMed ID: 12364621
Correlation between BRCA1 expression and apoptosis-related biological parameters in sporadic breast carcinomas.
Yang Q, Yoshimura G, Nakamura M, Nakamura Y, Suzuma T, Umemura T, Mori I, Sakurai T, Kakudo K
Anticancer Res. 2002
PubMed ID: 12552965
A brief assessment of concerns associated with genetic testing for cancer: the Multidimensional Impact of Cancer Risk Assessment (MICRA) questionnaire.
Cella D, Hughes C, Peterman A, Chang CH, Peshkin BN, Schwartz MD, Wenzel L, Lemke A, Marcus AC, Lerman C
Health Psychol. 2002
PubMed ID: 12433008
BRCA1 supports XIST RNA concentration on the inactive X chromosome.
Ganesan S, Silver DP, Greenberg RA, Avni D, Drapkin R, Miron A, Mok SC, Randrianarison V, Brodie S, Salstrom J, Rasmussen TP, Klimke A, Marrese C, Marahrens Y, Deng CX, Feunteun J, Livingston DM
Cell. 2002
PubMed ID: 12419249
Androgen receptor CAG repeat length in Jewish Israeli women who are BRCA1/2 mutation carriers: association with breast/ovarian cancer phenotype.
Dagan E, Friedman E, Paperna T, Carmi N, Gershoni-Baruch R
Eur J Hum Genet. 2002
PubMed ID: 12404104
Clustering of variations and haplotype analysis in the highly variable region of exon 11 of BRCA1 in Chinese women with sporadic breast cancer.
Li Y, Zhang S, Xiao C, Su Z, Zhao Y, Chen W, Zhang G
Hum Mutat. 2002
PubMed ID: 12402341
A low frequency of non-founder BRCA1 mutations in Ashkenazi Jewish breast-ovarian cancer families.
Phelan CM, Kwan E, Jack E, Li S, Morgan C, Aubé J, Hanna D, Narod SA
Hum Mutat. 2002
PubMed ID: 12402332
Subcellular localization of the BRCA1 gene product in mitotic cells.
Lotti LV, Ottini L, D'Amico C, Gradini R, Cama A, Belleudi F, Frati L, Torrisi MR, Mariani-Costantini R
Genes Chromosomes Cancer. 2002
PubMed ID: 12353262
Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells.
Kawai H, Li H, Chun P, Avraham S, Avraham HK
Oncogene. 2002
PubMed ID: 12400015
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain.
Kobayashi J, Tauchi H, Sakamoto S, Nakamura A, Morishima K, Matsuura S, Kobayashi T, Tamai K, Tanimoto K, Komatsu K
Curr Biol. 2002
PubMed ID: 12419185
Survival in prospectively ascertained familial breast cancer: analysis of a series stratified by tumour characteristics, BRCA mutations and oophorectomy.
Møller P, Borg A, Evans DG, Haites N, Reis MM, Vasen H, Anderson E, Steel CM, Apold J, Goudie D, Howell A, Lalloo F, Maehle L, Gregory H, Heimdal K
Int J Cancer. 2002
PubMed ID: 12237897
Analysis of BRCA1, TP53, and TSG101 germline mutations in German breast and/or ovarian cancer families.
Balz V, Prisack HB, Bier H, Bojar H
Cancer Genet Cytogenet. 2002
PubMed ID: 12505256
BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains.
Magnard C, Bachelier R, Vincent A, Jaquinod M, Kieffer S, Lenoir GM, Venezia ND
Oncogene. 2002
PubMed ID: 12360400
[Frequency of the 185delAG mutation in the BRCA1 gene in Chilean healthy women with family history of breast cancer]
Jara L, Ampuero S, Seccia L, Bustamante M, Blanco R, Santibáñez E, Reyes JM, Ojeda JM
Rev Med Chil. 2002
PubMed ID: 12491828
Loss of heterozygosity of p53, BRCA1, VHL, and estrogen receptor genes in breast carcinoma: correlation with related protein products and morphologic features.
Otis CN, Krebs PA, Albuquerque A, Quezado MM, San Juan X, Sobel ME, Merino MJ
Int J Surg Pathol. 2002
PubMed ID: 12490973
Insulin-like growth factor I polymorphism and breast cancer risk in Jewish women.
Figer A, Karasik YP, Baruch RG, Chetrit A, Papa MZ, Sade RB, Rizel S, Friedman E, Riezel S
Isr Med Assoc J. 2002
PubMed ID: 12389335
Utilization of breast cancer screening in a clinically based sample of women after BRCA1/2 testing.
Peshkin BN, Schwartz MD, Isaacs C, Hughes C, Main D, Lerman C
Cancer Epidemiol Biomarkers Prev. 2002
PubMed ID: 12376518
Psychological impact of genetic testing in women from high-risk breast cancer families.
Meiser B, Butow P, Friedlander M, Barratt A, Schnieden V, Watson M, Brown J, Tucker K
Eur J Cancer. 2002
PubMed ID: 12376208
[Analysis of mutation sites of BRCA1 gene in Chinese patients with breast cancer]
Ke Y, Wang X, Feng M, Wei C, Jiang Z, Jin L, Lu D
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002
PubMed ID: 12362311
BRCA1 interacts directly with the Fanconi anemia protein FANCA.
Folias A, Matkovic M, Bruun D, Reid S, Hejna J, Grompe M, D'Andrea A, Moses R
Hum Mol Genet. 2002
PubMed ID: 12354784
Highlight: BRCA1 and BRCA2 proteins in breast cancer.
Daniel DC
Microsc Res Tech. 2002
PubMed ID: 12242698
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.
Taniguchi T, Garcia-Higuera I, Andreassen PR, Gregory RC, Grompe M, D'Andrea AD
Blood. 2002
PubMed ID: 12239151
Inactivation of BRCA1 and BRCA2 in ovarian cancer.
Hilton JL, Geisler JP, Rathe JA, Hattermann-Zogg MA, DeYoung B, Buller RE
J Natl Cancer Inst. 2002
PubMed ID: 12237285
Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program.
Brose MS, Rebbeck TR, Calzone KA, Stopfer JE, Nathanson KL, Weber BL
J Natl Cancer Inst. 2002
PubMed ID: 12237282
Cancer Incidence in BRCA1 mutation carriers.
Thompson D, Easton DF, Breast Cancer Linkage Consortium
J Natl Cancer Inst. 2002
PubMed ID: 12237281
Cancer risks in BRCA1 carriers: time for the next generation of studies.
Gruber SB, Petersen GM
J Natl Cancer Inst. 2002
PubMed ID: 12237273
Roles of BRCA1 in centrosome duplication.
Deng CX
Oncogene. 2002
PubMed ID: 12214252
BRCA1-induced apoptosis involves inactivation of ERK1/2 activities.
Yan Y, Haas JP, Kim M, Sgagias MK, Cowan KH
J Biol Chem. 2002
PubMed ID: 12082091
Creating a tool-kit for exploring BRCA1 function.
Parvin JD
Cancer Biol Ther. 2002
PubMed ID: 12496478
Mutations in the BRCT domain confer temperature sensitivity to BRCA1 in transcription activation.
Carvalho MA, Billack B, Chan E, Worley T, Cayanan C, Monteiro AN
Cancer Biol Ther. 2002
PubMed ID: 12496477
A naturally occurring allele of BRCA1 coding for a temperature-sensitive mutant protein.
Worley T, Vallon-Christersson J, Billack B, Borg A, Monteiro AN
Cancer Biol Ther. 2002
PubMed ID: 12496476
Transactivation of repair genes by BRCA1.
El-Deiry WS
Cancer Biol Ther. 2002
PubMed ID: 12496474
BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair.
Hartman AR, Ford JM
Nat Genet. 2002
PubMed ID: 12195423
Contribution of BRCA1 and BRCA2 mutations to breast and ovarian cancer in Pakistan.
Liede A, Malik IA, Aziz Z, Rios Pd Pde L, Kwan E, Narod SA
Am J Hum Genet. 2002
PubMed ID: 12181777
Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation.
Xu B, O'Donnell AH, Kim ST, Kastan MB
Cancer Res. 2002
PubMed ID: 12183412
BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks.
Zhong Q, Chen CF, Chen PL, Lee WH
J Biol Chem. 2002
PubMed ID: 12039951
Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis.
Zhan Q, Jin S, Ng B, Plisket J, Shangary S, Rathi A, Brown KD, Baskaran R
Oncogene. 2002
PubMed ID: 12149654
Anticipation in hereditary breast cancer.
Dagan E, Gershoni-Baruch R
Clin Genet. 2002
PubMed ID: 12220452
Genetic counseling in hereditary breast/ovarian cancer in Israel: psychosocial impact and retention of genetic information.
DiCastro M, Frydman M, Friedman I, Shiri-Sverdlov R, Papa MZ, Goldman B, Friedman E
Am J Med Genet. 2002
PubMed ID: 12210341
Reduced Brca1 protein expression in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinomas.
Okochi E, Miyamoto K, Wakazono K, Shima H, Sugimura T, Ushijima T
Mol Carcinog. 2002
PubMed ID: 12203372
The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme.
Chiba N, Parvin JD
Cancer Res. 2002
PubMed ID: 12154023
Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer.
Weaver Z, Montagna C, Xu X, Howard T, Gadina M, Brodie SG, Deng CX, Ried T
Oncogene. 2002
PubMed ID: 12140760
BRCA1 regulates the interferon gamma-mediated apoptotic response.
Andrews HN, Mullan PB, McWilliams S, Sebelova S, Quinn JE, Gilmore PM, McCabe N, Pace A, Koller B, Johnston PG, Haber DA, Harkin DP
J Biol Chem. 2002
PubMed ID: 12011077
Characterisation of the BRCT domains of the breast cancer susceptibility gene product BRCA1.
Ekblad CM, Wilkinson HR, Schymkowitz JW, Rousseau F, Freund SM, Itzhaki LS
J Mol Biol. 2002
PubMed ID: 12096901
Detection of large rearrangements of exons 13 and 22 in the BRCA1 gene in German families.
Hofmann W, Wappenschmidt B, Berhane S, Schmutzler R, Scherneck S
J Med Genet. 2002
PubMed ID: 12114493
BRCA1 and BRCA2 mutations in Turkish familial and non-familial ovarian cancer patients: a high incidence of mutations in non-familial cases.
Yazici H, Glendon G, Yazici H, Burnie SJ, Saip P, Buyru F, Bengisu E, Andrulis IL, Dalay N, Ozcelik H
Hum Mutat. 2002
PubMed ID: 12112655
JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.
Hu YF, Li R
Genes Dev. 2002
PubMed ID: 12080089
Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase.
Chen A, Kleiman FE, Manley JL, Ouchi T, Pan ZQ
J Biol Chem. 2002
PubMed ID: 11927591
BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export.
Fabbro M, Rodriguez JA, Baer R, Henderson BR
J Biol Chem. 2002
PubMed ID: 11925436
Pathological splice mutations outside the invariant AG/GT splice sites of BRCA1 exon 5 increase alternative transcript levels in the 5' end of the BRCA1 gene.
Claes K, Vandesompele J, Poppe B, Dahan K, Coene I, De Paepe A, Messiaen L
Oncogene. 2002
PubMed ID: 12037674
A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer.
Li H, Lee TH, Avraham H
J Biol Chem. 2002
PubMed ID: 11916966
Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor.
McGowan CH
Bioessays. 2002
PubMed ID: 12111733
BRCA1 and BRCA2 mutations in breast cancer patients from Saudi Arabia.
El-Harith el-HA, Abdel-Hadi MS, Steinmann D, Dork T
Saudi Med J. 2002
PubMed ID: 12070551
BRCAPRO validation, sensitivity of genetic testing of BRCA1/BRCA2, and prevalence of other breast cancer susceptibility genes.
Berry DA, Iversen ES, Gudbjartsson DF, Hiller EH, Garber JE, Peshkin BN, Lerman C, Watson P, Lynch HT, Hilsenbeck SG, Rubinstein WS, Hughes KS, Parmigiani G
J Clin Oncol. 2002
PubMed ID: 12039933
Effect of germ-line genetic variation on breast cancer survival in a population-based study.
Goode EL, Dunning AM, Kuschel B, Healey CS, Day NE, Ponder BA, Easton DF, Pharoah PP
Cancer Res. 2002
PubMed ID: 12036913
BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets.
MacLachlan TK, Takimoto R, El-Deiry WS
Mol Cell Biol. 2002
PubMed ID: 12024039
Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation.
Foray N, Marot D, Randrianarison V, Venezia ND, Picard D, Perricaudet M, Favaudon V, Jeggo P
Mol Cell Biol. 2002
PubMed ID: 12024016
Expression of BRCA1 and BRCA2 in different tumor cell lines with various growth status.
Vissac C, Peffault De Latour M, Communal Y, Bignon YJ, Bernard-Gallon DJ
Clin Chim Acta. 2002
PubMed ID: 11983207
BRCA1 transcriptionally regulates genes involved in breast tumorigenesis.
Welcsh PL, Lee MK, Gonzalez-Hernandez RM, Black DJ, Mahadevappa M, Swisher EM, Warrington JA, King MC
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12032322
Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation.
Kauff ND, Satagopan JM, Robson ME, Scheuer L, Hensley M, Hudis CA, Ellis NA, Boyd J, Borgen PI, Barakat RR, Norton L, Castiel M, Nafa K, Offit K
N Engl J Med. 2002
PubMed ID: 12023992
CGH-targeted linkage analysis reveals a possible BRCA1 modifier locus on chromosome 5q.
Nathanson KL, Shugart YY, Omaruddin R, Szabo C, Goldgar D, Rebbeck TR, Weber BL
Hum Mol Genet. 2002
PubMed ID: 12019214
Structural determinants of BRCA1 translational regulation.
Sobczak K, Krzyzosiak WJ
J Biol Chem. 2002
PubMed ID: 11877386
BRCA1 transactivates the cyclin-dependent kinase inhibitor p27(Kip1).
Williamson EA, Dadmanesh F, Koeffler HP
Oncogene. 2002
PubMed ID: 12082635
Genomic instability in mice lacking histone H2AX.
Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E, Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M, Camerini-Otero RD, Tessarollo L, Livak F, Manova K, Bonner WM, Nussenzweig MC, Nussenzweig A
Science. 2002
PubMed ID: 11934988
One year follow-up of women opting for presymptomatic testing for BRCA1 and BRCA2: emotional impact of the test outcome and decisions on risk management (surveillance or prophylactic surgery).
Lodder LN, Frets PG, Trijsburg RW, Meijers-Heijboer EJ, Klijn JG, Seynaeve C, van Geel AN, Tilanus MM, Bartels CC, Verhoog LC, Brekelmans CT, Burger CW, Niermeijer MF
Breast Cancer Res Treat. 2002
PubMed ID: 12088120
The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2.
Lakhani SR, Van De Vijver MJ, Jacquemier J, Anderson TJ, Osin PP, McGuffog L, Easton DF
J Clin Oncol. 2002
PubMed ID: 11981002
Contribution of BRCA1 and BRCA2 to familial ovarian cancer: a gynecologic oncology group study.
Reedy M, Gallion H, Fowler JM, Kryscio R, Smith SA
Gynecol Oncol. 2002
PubMed ID: 11972384
Breast cancer risk in Ashkenazi BRCA1/2 mutation carriers: effects of reproductive history.
Hartge P, Chatterjee N, Wacholder S, Brody LC, Tucker MA, Struewing JP
Epidemiology. 2002
PubMed ID: 11964925
Characterization of 2 novel and 2 recurring BRCA1 germline mutations in breast and/or ovarian carcinoma patients from the area of Naples.
Curci A, Capasso I, Romano A, Bruni P, Motti ML, Pignata S, D'Aiuto G, Casamassimi A, D'Urso M, Fusco A, Viglietto G
Int J Oncol. 2002
PubMed ID: 11956590
Predictive testing for BRCA1/2: attributes, risk perception and management in a multi-centre clinical cohort.
Foster C, Evans DG, Eeles R, Eccles D, Ashley S, Brooks L, Davidson R, Mackay J, Morrison PJ, Watson M
Br J Cancer. 2002
PubMed ID: 11953874
A change in the last base of BRCA1 exon 23, 5586G-->A, results in abnormal RNA splicing.
Ladopoulou A, Konstantopoulou I, Armaou S, Efstathiou E, Mihalatos M, Nasioulas G, Bardi G, Pandis N, Yannoukakos D, Athens, Hellenic Cooperative Oncology Group
Cancer Genet Cytogenet. 2002
PubMed ID: 12034536
Interpreting three new and unique BRCA1 mutations in an Ashkenazi Jewish patient.
Hendrickson BC, Nielsen DR, Gaglio CA, Wonderlick A, Fishman DA, Frank TS, Scholl T
Clin Genet. 2002
PubMed ID: 12030901
BRCA1 and BRCA2 heterozygosity and repair of X-ray-induced DNA damage.
Nieuwenhuis B, Van Assen-Bolt AJ, Van Waarde-Verhagen MA, Sijmons RH, Van der Hout AH, Bauch T, Streffer C, Kampinga HH
Int J Radiat Biol. 2002
PubMed ID: 12020440
[Genetic test and prophylactic treatment in breast cancer families]
Miyoshi Y, Noguchi S
Gan To Kagaku Ryoho. 2002
PubMed ID: 11977534
A BRCA1 mutation in Native North American families.
Liede A, Jack E, Hegele RA, Narod SA
Hum Mutat. 2002
PubMed ID: 11933205
Germline BRCA1 promoter deletions in UK and Australian familial breast cancer patients: Identification of a novel deletion consistent with BRCA1:psiBRCA1 recombination.
Brown MA, Lo LJ, Catteau A, Xu CF, Lindeman GJ, Hodgson S, Solomon E
Hum Mutat. 2002
PubMed ID: 11933198
The BRCA2 372 HH genotype is associated with risk of breast cancer in Australian women under age 60 years.
Spurdle AB, Hopper JL, Chen X, Dite GS, Cui J, McCredie MR, Giles GG, Ellis-Steinborner S, Venter DJ, Newman B, Southey MC, Chenevix-Trench G
Cancer Epidemiol Biomarkers Prev. 2002
PubMed ID: 11927503
Variation in BRCA1 cancer risks by mutation position.
Thompson D, Easton D, Breast Cancer Linkage Consortium
Cancer Epidemiol Biomarkers Prev. 2002
PubMed ID: 11927492
BRCA1 and BRCA2 mutations among breast cancer patients from the Philippines.
De Leon Matsuda ML, Liede A, Kwan E, Mapua CA, Cutiongco EM, Tan A, Borg A, Narod SA
Int J Cancer. 2002
PubMed ID: 11920621
Distinct BRCA1 rearrangements involving the BRCA1 pseudogene suggest the existence of a recombination hot spot.
Puget N, Gad S, Perrin-Vidoz L, Sinilnikova OM, Stoppa-Lyonnet D, Lenoir GM, Mazoyer S
Am J Hum Genet. 2002
PubMed ID: 11880951
Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation.
Trenz K, Rothfuss A, Schütz P, Speit G
Mutat Res. 2002
PubMed ID: 11890937
Utilization of BRCA1/2 genetic testing in the clinical setting: report from a single institution.
Lee SC, Bernhardt BA, Helzlsouer KJ
Cancer. 2002
PubMed ID: 11920551
Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals.
Frank TS, Deffenbaugh AM, Reid JE, Hulick M, Ward BE, Lingenfelter B, Gumpper KL, Scholl T, Tavtigian SV, Pruss DR, Critchfield GC
J Clin Oncol. 2002
PubMed ID: 11896095
Identification of residues required for the interaction of BARD1 with BRCA1.
Morris JR, Keep NH, Solomon E
J Biol Chem. 2002
PubMed ID: 11773071
BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs.
Fan W, Jin S, Tong T, Zhao H, Fan F, Antinore MJ, Rajasekaran B, Wu M, Zhan Q
J Biol Chem. 2002
PubMed ID: 11777930
The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity.
Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE
J Biol Chem. 2002
PubMed ID: 11751867
The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients.
Elledge SJ, Amon A
Cancer Cell. 2002
PubMed ID: 12086871
Retroviral transduction of splice variant Brca1-Delta11 or mutant Brca1-W1777Stop causes mouse epithelial mammary atypical duct hyperplasia.
Bachelier R, Vincent A, Mathevet P, Magdinier F, Lenoir GM, Frappart L
Virchows Arch. 2002
PubMed ID: 11889595
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.
Joo WS, Jeffrey PD, Cantor SB, Finnin MS, Livingston DM, Pavletich NP
Genes Dev. 2002
PubMed ID: 11877378
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.
Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J
Genes Dev. 2002
PubMed ID: 11877377
Outcome of preventive surgery and screening for breast and ovarian cancer in BRCA mutation carriers.
Scheuer L, Kauff N, Robson M, Kelly B, Barakat R, Satagopan J, Ellis N, Hensley M, Boyd J, Borgen P, Norton L, Offit K
J Clin Oncol. 2002
PubMed ID: 11870168
Recurrent BRCA1 and BRCA2 germline mutations in ovarian cancer: a founder mutation of BRCA1 identified in the Chinese population.
Khoo US, Chan KY, Cheung AN, Xue WC, Shen DH, Fung KY, Ngan HY, Choy KW, Pang CP, Poon CS, Poon AY, Ozcelik H
Hum Mutat. 2002
PubMed ID: 11857749
Low frequency of recurrent BRCA1 and BRCA2 mutations in Spain.
Llort G, Muñoz CY, Tuser MP, Guillermo IB, Lluch JR, Bale AE, Franco MA
Hum Mutat. 2002
PubMed ID: 11857748
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage.
Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH, Brody LC
Nat Genet. 2002
PubMed ID: 11836499
BRCA1 and BRCA2 mutation frequency in women evaluated in a breast cancer risk evaluation clinic.
Shih HA, Couch FJ, Nathanson KL, Blackwood MA, Rebbeck TR, Armstrong KA, Calzone K, Stopfer J, Seal S, Stratton MR, Weber BL
J Clin Oncol. 2002
PubMed ID: 11844822
Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2.
Buchholz TA, Wu X, Hussain A, Tucker SL, Mills GB, Haffty B, Bergh S, Story M, Geara FB, Brock WA
Int J Cancer. 2002
PubMed ID: 11807777
Diagnostic criteria for testing for BRCA1 and BRCA2: the experience of the Department of Defense Familial Breast/Ovarian Cancer Research Project.
Fries MH, Holt C, Carpenter I, Carter CL, Daniels J, Flanagan J, Murphy K, Hailey BJ, Martin L, Hume R, Hudson G, Cadman M, Weatherly R, Nunes ME
Mil Med. 2002
PubMed ID: 11873550
Comprehensive analysis of 989 patients with breast or ovarian cancer provides BRCA1 and BRCA2 mutation profiles and frequencies for the German population.
Meindl A, German Consortium for Hereditary Breast and Ovarian Cancer
Int J Cancer. 2002
PubMed ID: 11802209
Association between BRCA1 and BRCA2 mutations and cancer phenotype in Spanish breast/ovarian cancer families: implications for genetic testing.
de la Hoya M, Osorio A, Godino J, Sulleiro S, Tosar A, Perez-Segura P, Fernandez C, Rodríguez R, Díaz-Rubio E, Benítez J, Devilee P, Caldés T
Int J Cancer. 2002
PubMed ID: 11802208
BRCA1 and BRCA2 mutations in Russian familial breast cancer.
Tereschenko IV, Basham VM, Ponder BA, Pharoah PD
Hum Mutat. 2002
PubMed ID: 11793480
Cancer susceptibility and the functions of BRCA1 and BRCA2.
Venkitaraman AR
Cell. 2002
PubMed ID: 11832208
'Srcasm: a novel Src activating and signaling molecule.
Seykora JT, Mei L, Dotto GP, Stein PL
J Biol Chem. 2002
PubMed ID: 11711534
Estimates of the likely prophylactic effect of tamoxifen in women with high risk BRCA1 and BRCA2 mutations.
Duffy SW, Nixon RM
Br J Cancer. 2002
PubMed ID: 11870509
All in the family: evaluation of the process and content of sisters' communication about BRCA1 and BRCA2 genetic test results.
Hughes C, Lerman C, Schwartz M, Peshkin BN, Wenzel L, Narod S, Corio C, Tercyak KP, Hanna D, Isaacs C, Main D
Am J Med Genet. 2002
PubMed ID: 11807889
Impact of BRCA1/BRCA2 mutation testing on psychologic distress in a clinic-based sample.
Schwartz MD, Peshkin BN, Hughes C, Main D, Isaacs C, Lerman C
J Clin Oncol. 2002
PubMed ID: 11786581
Effect of BRCA mutations on the length of survival in epithelial ovarian tumors.
Ben David Y, Chetrit A, Hirsh-Yechezkel G, Friedman E, Beck BD, Beller U, Ben-Baruch G, Fishman A, Levavi H, Lubin F, Menczer J, Piura B, Struewing JP, Modan B, National Israeli Study of Ovarian Cancer
J Clin Oncol. 2002
PubMed ID: 11786575
A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes.
Antoniou AC, Pharoah PD, McMullan G, Day NE, Stratton MR, Peto J, Ponder BJ, Easton DF
Br J Cancer. 2002
PubMed ID: 11857015
A European case-only study on familial breast cancer.
Berrino F, Pasanisi P, Berrino J, Curtosi P, Bellati C
IARC Sci Publ. 2002
PubMed ID: 12484126
Risk factors for ovarian cancer and early-onset breast cancer in Mongolia.
Elit L, Baigal G, Jack E, Munkhtaivan A, Narod SA
Eur J Gynaecol Oncol. 2002
PubMed ID: 12440810
Germline mutations in the BRCA1 gene predisposing to breast and ovarian cancers in Upper Silesia population.
Grzybowska E, Siemińska M, Zientek H, Kalinowska E, Michalska J, Utracka-Hutka B, Rogozińska-Szczepka J, Kaźmierczak-Maciejewska M
Acta Biochim Pol. 2002
PubMed ID: 12362976
Progress of a Comprehensive Familial Cancer Genetic Counseling Program in the Era of BRCA1 and BRCA2.
Hartenbach EM, Becker JM, Grosen EA, Bailey HH, Petereit DG, Laxova R, Schink JC
Genet Test. 2002
PubMed ID: 12229876
Questions raised by BRCA1/2-carrier screening programs.
Gilbert F
Genet Test. 2002
PubMed ID: 12229875
Characterization of common BRCA1 and BRCA2 variants.
Deffenbaugh AM, Frank TS, Hoffman M, Cannon-Albright L, Neuhausen SL
Genet Test. 2002
PubMed ID: 12215251
Germline BRCA1 mutation analysis in Indian breast/ovarian cancer families.
Kumar BV, Lakhotia S, Ankathil R, Madhavan J, Jayaprakash PG, Nair MK, Somasundaram K
Cancer Biol Ther. 2002
PubMed ID: 12170759
Analysis of 5382insC (BRCA1) and 6174delT (BRCA2) mutations in 382 healthy Chilean women with a family history of breast cancer.
Jara L, Ampuero S, Seccia L, Bustamante M, Blanco R, Ojeda JM
Biol Res. 2002
PubMed ID: 12125210
[Investigation of mutations of BRCA1 and BRCA2 genes in 52 breast cancer patients]
Tereshchenko IV, Béshém VM, Slonimskaia EM, Ponder BA, Férokh PD, Velichko SA, Shagiakhmetova RA
Vopr Onkol. 2002
PubMed ID: 12101561
Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer.
Yassaee VR, Zeinali S, Harirchi I, Jarvandi S, Mohagheghi MA, Hornby DP, Dalton A
Breast Cancer Res. 2002
PubMed ID: 12100744
Oral contraceptives and risk of familial breast cancer.
Heimdal K, Skovlund E, Møller P
Cancer Detect Prev. 2002
PubMed ID: 12088199
Analysis of BRCA1 and BRCA2 in breast and breast/ovarian cancer families shows population substructure in the Iberian peninsula.
Vega A, Torres M, Martínez JI, Ruiz-Ponte C, Barros F, Carracedo A
Ann Hum Genet. 2002
PubMed ID: 12014998
Tumor formation in Brca1 conditional mutant mice.
Deng CX
Environ Mol Mutagen. 2002
PubMed ID: 11921186
Are Trp53 rescue of Brca1 embryonic lethality and Trp53/Brca1 breast cancer association related?
McAllister KA, Wiseman RW
Breast Cancer Res. 2002
PubMed ID: 11879563
BRCA1 and BRCA2 mutations in a population-based study of male breast cancer.
Basham VM, Lipscombe JM, Ward JM, Gayther SA, Ponder BA, Easton DF, Pharoah PD
Breast Cancer Res. 2002
PubMed ID: 11879560
Loss of BRCA1 expression in sporadic male breast carcinoma.
Sun X, Gong Y, Rao MS, Badve S
Breast Cancer Res Treat. 2002
PubMed ID: 11859870
p300 Modulates the BRCA1 inhibition of estrogen receptor activity.
Fan S, Ma YX, Wang C, Yuan RQ, Meng Q, Wang JA, Erdos M, Goldberg ID, Webb P, Kushner PJ, Pestell RG, Rosen EM
Cancer Res. 2002
PubMed ID: 11782371
Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: requirements for metabolism of benzo[a]pyrene to 7r,8t-dihydroxy-9t,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
Jeffy BD, Chirnomas RB, Chen EJ, Gudas JM, Romagnolo DF
Cancer Res. 2002
PubMed ID: 11782367
Interaction with BRCA2 suggests a role for filamin-1 (hsFLNa) in DNA damage response.
Yuan Y, Shen Z
J Biol Chem. 2001
PubMed ID: 11602572
BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations.
Ye Q, Hu YF, Zhong H, Nye AC, Belmont AS, Li R
J Cell Biol. 2001
PubMed ID: 11739404
Novel germline BRCA1 and BRCA2 mutations in breast and breast/ovarian cancer families from the Czech Republic.
Machackova E, Damborsky J, Valik D, Foretova L
Hum Mutat. 2001
PubMed ID: 11748848
BRCA1 germline mutations and polymorphisms in a clinic-based series of ovarian cancer cases: a Gynecologic Oncology Group study.
Smith SA, Richards WE, Caito K, Hanjani P, Markman M, DeGeest K, Gallion HH
Gynecol Oncol. 2001
PubMed ID: 11733976
[Information to families with hereditary breast and ovarian cancer]
Levin T, Reichelt J, Heimdal K, Møller P
Tidsskr Nor Laegeforen. 2001
PubMed ID: 11826460
Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1) Breast Cancer Prevention Trial.
King MC, Wieand S, Hale K, Lee M, Walsh T, Owens K, Tait J, Ford L, Dunn BK, Costantino J, Wickerham L, Wolmark N, Fisher B, National Surgical Adjuvant Breast and Bowel Project
JAMA. 2001
PubMed ID: 11710890
Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice.
Brodie SG, Xu X, Qiao W, Li WM, Cao L, Deng CX
Oncogene. 2001
PubMed ID: 11709723
Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers.
Hartmann LC, Sellers TA, Schaid DJ, Frank TS, Soderberg CL, Sitta DL, Frost MH, Grant CS, Donohue JH, Woods JE, McDonnell SK, Vockley CW, Deffenbaugh A, Couch FJ, Jenkins RB
J Natl Cancer Inst. 2001
PubMed ID: 11698567
Clinical and pathological features of BRCA1 associated carcinomas in a hospital-based sample of Dutch breast cancer patients.
de Bock GH, Tollenaar RA, Papelard H, Cornelisse CJ, Devilee P, van de Vijver MJ
Br J Cancer. 2001
PubMed ID: 11720473
BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions.
Brzovic PS, Meza JE, King MC, Klevit RE
J Biol Chem. 2001
PubMed ID: 11526114
Identification of a gamma-tubulin-binding domain in BRCA1.
Hsu LC, Doan TP, White RL
Cancer Res. 2001
PubMed ID: 11691781
Effect of DNA damage on a BRCA1 complex.
Wu-Baer F, Baer R
Nature. 2001
PubMed ID: 11689934
Functional mammary gland development and oncogene-induced tumor formation are not affected by the absence of the retinoblastoma gene.
Robinson GW, Wagner KU, Hennighausen L
Oncogene. 2001
PubMed ID: 11704837
Redistribution of BRCA1 among four different protein complexes following replication blockage.
Chiba N, Parvin JD
J Biol Chem. 2001
PubMed ID: 11504724
Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals.
Sarkisian CJ, Master SR, Huber LJ, Ha SI, Chodosh LA
J Biol Chem. 2001
PubMed ID: 11477095
The western Swedish BRCA1 founder mutation 3171ins5; a 3.7 cM conserved haplotype of today is a reminiscence of a 1500-year-old mutation.
Bergman A, Einbeigi Z, Olofsson U, Taib Z, Wallgren A, Karlsson P, Wahlström J, Martinsson T, Nordling M
Eur J Hum Genet. 2001
PubMed ID: 11781691
Ovarian cancer BRCA1 mutation detection: Protein truncation test (PTT) outperforms single strand conformation polymorphism analysis (SSCP).
Geisler JP, Hatterman-Zogg MA, Rathe JA, Lallas TA, Kirby P, Buller RE
Hum Mutat. 2001
PubMed ID: 11668617
Progesterone receptor variant increases ovarian cancer risk in BRCA1 and BRCA2 mutation carriers who were never exposed to oral contraceptives.
Runnebaum IB, Wang-Gohrke S, Vesprini D, Kreienberg R, Lynch H, Moslehi R, Ghadirian P, Weber B, Godwin AK, Risch H, Garber J, Lerman C, Olopade OI, Foulkes WD, Karlan B, Warner E, Rosen B, Rebbeck T, Tonin P, Dubé MP, Kieback DG, Narod SA
Pharmacogenetics. 2001
PubMed ID: 11668223
Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.
Williams RS, Green R, Glover JN
Nat Struct Biol. 2001
PubMed ID: 11573086
Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.
Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE
Nat Struct Biol. 2001
PubMed ID: 11573085
An interactive computer program can effectively educate patients about genetic testing for breast cancer susceptibility.
Green MJ, Biesecker BB, McInerney AM, Mauger D, Fost N
Am J Med Genet. 2001
PubMed ID: 11562929
Mutations of the BRCA1 and BRCA2 genes in patients with bilateral breast cancer.
Steinmann D, Bremer M, Rades D, Skawran B, Siebrands C, Karstens JH, Dörk T
Br J Cancer. 2001
PubMed ID: 11556836
Psychological impact of genetic counselling and testing in women previously diagnosed with breast cancer.
Randall J, Butow P, Kirk J, Tucker K
Intern Med J. 2001
PubMed ID: 11584901
A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers.
Wang WW, Spurdle AB, Kolachana P, Bove B, Modan B, Ebbers SM, Suthers G, Tucker MA, Kaufman DJ, Doody MM, Tarone RE, Daly M, Levavi H, Pierce H, Chetrit A, Yechezkel GH, Chenevix-Trench G, Offit K, Godwin AK, Struewing JP
Cancer Epidemiol Biomarkers Prev. 2001
PubMed ID: 11535547
Impact of educational print materials on knowledge, attitudes, and interest in BRCA1/BRCA2: testing among Ashkenazi Jewish women.
Schwartz MD, Benkendorf J, Lerman C, Isaacs C, Ryan-Robertson A, Johnson L
Cancer. 2001
PubMed ID: 11550168
Family history of breast and ovarian cancers and BRCA1 and BRCA2 mutations in a population-based series of early-onset breast cancer.
Loman N, Johannsson O, Kristoffersson U, Olsson H, Borg A
J Natl Cancer Inst. 2001
PubMed ID: 11504767
BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor.
Zheng L, Annab LA, Afshari CA, Lee WH, Boyer TG
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11493692
Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding.
Fan S, Yuan R, Ma YX, Xiong J, Meng Q, Erdos M, Zhao JN, Goldberg ID, Pestell RG, Rosen EM
Oncogene. 2001
PubMed ID: 11521194
Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1.
Wang Q, Zhang H, Guerrette S, Chen J, Mazurek A, Wilson T, Slupianek A, Skorski T, Fishel R, Greene MI
Oncogene. 2001
PubMed ID: 11498787
Evidence of a founder mutation of BRCA1 in a highly homogeneous population from southern Italy with breast/ovarian cancer.
Baudi F, Quaresima B, Grandinetti C, Cuda G, Faniello C, Tassone P, Barbieri V, Bisegna R, Ricevuto E, Conforti S, Viel A, Marchetti P, Ficorella C, Radice P, Costanzo F, Venuta S
Hum Mutat. 2001
PubMed ID: 11462242
Detection of germline mutations in the BRCA1 gene by RNA-based sequencing.
Jakubowska A, Górski B, Byrski T, Huzarski T, Gronwald J, Menkiszak J, Cybulski C, Debniak T, Hadaczek P, Scott RJ, Lubinski J
Hum Mutat. 2001
PubMed ID: 11462239
Survival of breast cancer patients in BRCA1, BRCA2, and non-BRCA1/2 breast cancer families: a relative survival analysis from Finland.
Eerola H, Vahteristo P, Sarantaus L, Kyyrönen P, Pyrhönen S, Blomqvist C, Pukkala E, Nevanlinna H, Sankila R
Int J Cancer. 2001
PubMed ID: 11433401
Parity, oral contraceptives, and the risk of ovarian cancer among carriers and noncarriers of a BRCA1 or BRCA2 mutation.
Modan B, Hartge P, Hirsh-Yechezkel G, Chetrit A, Lubin F, Beller U, Ben-Baruch G, Fishman A, Menczer J, Ebbers SM, Tucker MA, Wacholder S, Struewing JP, Friedman E, Piura B, National Israel Ovarian Cancer Study Group
N Engl J Med. 2001
PubMed ID: 11474660
The frequency of founder mutations in the BRCA1, BRCA2, and APC genes in Australian Ashkenazi Jews: implications for the generality of U.S. population data.
Bahar AY, Taylor PJ, Andrews L, Proos A, Burnett L, Tucker K, Friedlander M, Buckley MF
Cancer. 2001
PubMed ID: 11466700
[Clinical and pathological characteristics and clinical course of patients with breast cancer and BRCA1/BRCA2 mutations]
Pericay C, Díez O, Campos B, Balmaña J, Domènech M, Lerma E, Baena M, Maria Sabaté J, Gómez A, José López J, Baiget M, Alonso C
Med Clin (Barc). 2001
PubMed ID: 11481082
CAG and GGC repeat polymorphisms in the androgen receptor gene and breast cancer susceptibility in BRCA1/2 carriers and non-carriers.
Kadouri L, Easton DF, Edwards S, Hubert A, Kote-Jarai Z, Glaser B, Durocher F, Abeliovich D, Peretz T, Eeles RA
Br J Cancer. 2001
PubMed ID: 11437399
[Bilateral breast carcinoma and local recurrence: prevalence of BRCA-1 and BRCA-2 gene mutations in an unselected patient sample]
Bremer M, Steinmann D, Dörk T, Börger J, Rades D, Karstens JH
Strahlenther Onkol. 2001
PubMed ID: 11505617
The Tyr978X BRCA1 Mutation in Non-Ashkenazi Jews: Occurrence in High-Risk Families, General Population and Unselected Ovarian Cancer Patients.
Shiri-Sverdlov R, Gershoni-Baruch R, Ichezkel-Hirsch G, Gotlieb WH, Bruchim Bar-Sade R, Chetrit A, Rizel S, Modan B, Friedman E
Community Genet. 2001
PubMed ID: 11493753
Breast tumor immunophenotype of BRCA1-mutation carriers is influenced by age at diagnosis.
Vaziri SA, Krumroy LM, Elson P, Budd GT, Darlington G, Myles J, Tubbs RR, Casey G
Clin Cancer Res. 2001
PubMed ID: 11448907
Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.
Xu X, Qiao W, Linke SP, Cao L, Li WM, Furth PA, Harris CC, Deng CX
Nat Genet. 2001
PubMed ID: 11431698
Rb-associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1.
Chen GC, Guan LS, Yu JH, Li GC, Choi Kim HR, Wang ZY
Biochem Biophys Res Commun. 2001
PubMed ID: 11394910
Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice.
Deng CX
Mutat Res. 2001
PubMed ID: 11376699
Pathological features and BRCA1 mutation screening in premenopausal breast cancer patients.
Chang J, Hilsenbeck SG, Sng JH, Wong J, Ragu GC
Clin Cancer Res. 2001
PubMed ID: 11410514
Direct DNA binding by Brca1.
Paull TT, Cortez D, Bowers B, Elledge SJ, Gellert M
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11353843
BRCT domain interactions in the heterodimeric DNA repair protein XRCC1-DNA ligase III.
Dulic A, Bates PA, Zhang X, Martin SR, Freemont PS, Lindahl T, Barnes DE
Biochemistry. 2001
PubMed ID: 11352725
Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies.
Gatei M, Zhou BB, Hobson K, Scott S, Young D, Khanna KK
J Biol Chem. 2001
PubMed ID: 11278964
Tumorigenesis in mice carrying a truncating Brca1 mutation.
Ludwig T, Fisher P, Ganesan S, Efstratiadis A
Genes Dev. 2001
PubMed ID: 11358863
Tubal ligation and risk of ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study.
Narod SA, Sun P, Ghadirian P, Lynch H, Isaacs C, Garber J, Weber B, Karlan B, Fishman D, Rosen B, Tung N, Neuhausen SL
Lancet. 2001
PubMed ID: 11377596
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation.
Hashizume R, Fukuda M, Maeda I, Nishikawa H, Oyake D, Yabuki Y, Ogata H, Ohta T
J Biol Chem. 2001
PubMed ID: 11278247
A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage.
Hohenstein P, Kielman MF, Breukel C, Bennett LM, Wiseman R, Krimpenfort P, Cornelisse C, van Ommen GJ, Devilee P, Fodde R
Oncogene. 2001
PubMed ID: 11420664
Genetic counseling impacts decision for prophylactic surgery for patients perceived to be at high risk for breast cancer.
Morris KT, Johnson N, Krasikov N, Allen M, Dorsey P
Am J Surg. 2001
PubMed ID: 11448436
Effects of coping style and BRCA1 and BRCA2 test results on anxiety among women participating in genetic counseling and testing for breast and ovarian cancer risk.
Tercyak KP, Lerman C, Peshkin BN, Hughes C, Main D, Isaacs C, Schwartz MD
Health Psychol. 2001
PubMed ID: 11403219
Direct removal in the mouse of a floxed neo gene from a three-loxP conditional knockout allele by two novel approaches.
Xu X, Li C, Garrett-Beal L, Larson D, Wynshaw-Boris A, Deng CX
Genesis. 2001
PubMed ID: 11353511
Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity.
Ruffner H, Joazeiro CA, Hemmati D, Hunter T, Verma IM
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11320250
[CSNP discovery by two-dimensional gene scanning (TDGS)]
Suh Y
Exp Mol Med. 2001
PubMed ID: 11708324
Germline BRCA1 mutations in Iranian women with breast cancer.
Ghaderi A, Talei A, Farjadian S, Mosalaei A, Doroudchi M, Kimura H
Cancer Lett. 2001
PubMed ID: 11248423
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.
Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S, Wahrer DC, Sgroi DC, Lane WS, Haber DA, Livingston DM
Cell. 2001
PubMed ID: 11301010
c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells.
Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, Yezdani M, Reddy ES, Rao VN
Oncogene. 2001
PubMed ID: 11313879
A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers.
Levy-Lahad E, Lahad A, Eisenberg S, Dagan E, Paperna T, Kasinetz L, Catane R, Kaufman B, Beller U, Renbaum P, Gershoni-Baruch R
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11248061
The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression.
Kleiman FE, Manley JL
Cell. 2001
PubMed ID: 11257228
Risk of endometrial carcinoma associated with BRCA mutation.
Levine DA, Lin O, Barakat RR, Robson ME, McDermott D, Cohen L, Satagopan J, Offit K, Boyd J
Gynecol Oncol. 2001
PubMed ID: 11263938
Effectiveness of breast cancer surveillance in BRCA1/2 gene mutation carriers and women with high familial risk.
Brekelmans CT, Seynaeve C, Bartels CC, Tilanus-Linthorst MM, Meijers-Heijboer EJ, Crepin CM, van Geel AA, Menke M, Verhoog LC, van den Ouweland A, Obdeijn IM, Klijn JG, Rotterdam Committee for Medical and Genetic Counseling
J Clin Oncol. 2001
PubMed ID: 11181654
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.
Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, Grompe M, D'Andrea AD
Mol Cell. 2001
PubMed ID: 11239454
The androgen receptor and genetic susceptibility to ovarian cancer: results from a case series.
Levine DA, Boyd J
Cancer Res. 2001
PubMed ID: 11221880
The frequency of the predominant Jewish mutations in BRCA1 and BRCA2 in unselected Ashkenazi colorectal cancer patients.
Chen-Shtoyerman R, Figer A, Fidder HH, Rath P, Yeremin L, Bar Meir S, Friedman E, Theodor L
Br J Cancer. 2001
PubMed ID: 11207040
Heterozygosity for a mutation in Brca1 or Atm does not increase susceptibility to ENU-induced mammary tumors in Apc(Min)/+ mice.
Karabinis ME, Larson D, Barlow C, Wynshaw-Boris A, Moser AR
Carcinogenesis. 2001
PubMed ID: 11181458
Involvement of BRCA1 and BRCA2 in breast cancer in a western Finnish sub-population.
Pääkkönen K, Sauramo S, Sarantaus L, Vahteristo P, Hartikainen A, Vehmanen P, Ignatius J, Ollikainen V, Kääriäinen H, Vauramo E, Nevanlinna H, Krahe R, Holli K, Kere J
Genet Epidemiol. 2001
PubMed ID: 11180449
Evidence for purifying selection acting on silent sites in BRCA1.
Hurst LD, Pál C
Trends Genet. 2001
PubMed ID: 11173101
Brca1 and Brca2 protein expression patterns in different tissues of murine origin.
Bernard-Gallon DJ, De Latour MP, Sylvain V, Vissac C, Aunoble B, Chassagne J, Bignon YJ
Int J Oncol. 2001
PubMed ID: 11172592
Founder mutations of BRCA1 and BRCA2 in North American families of Polish origin that are affected with breast cancer.
de los Rios P, Jack E, Kuperstein G, Lynch H, Lubinski J, Narod SA
Am J Hum Genet. 2001
PubMed ID: 11170903
Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice.
Chandler J, Hohenstein P, Swing DA, Tessarollo L, Sharan SK
Genesis. 2001
PubMed ID: 11170347
Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells.
Gao B, Shen X, Kunos G, Meng Q, Goldberg ID, Rosen EM, Fan S
FEBS Lett. 2001
PubMed ID: 11163768
Expression profiles of BRCA1 splice variants in asynchronous and in G1/S synchronized tumor cell lines.
Orban TI, Olah E
Biochem Biophys Res Commun. 2001
PubMed ID: 11162473
Role of direct interaction in BRCA1 inhibition of estrogen receptor activity.
Fan S, Ma YX, Wang C, Yuan RQ, Meng Q, Wang JA, Erdos M, Goldberg ID, Webb P, Kushner PJ, Pestell RG, Rosen EM
Oncogene. 2001
PubMed ID: 11244506
Measuring women's preferences for breast cancer treatments and BRCA1/BRCA2 testing.
Cappelli M, Surh L, Humphreys L, Verma S, Logan D, Hunter A, Allanson J
Qual Life Res. 2001
PubMed ID: 11822793
Identification of proteins that interact with BRCA1 by Far-Western library screening.
Yarden RI, Brody LC
J Cell Biochem. 2001
PubMed ID: 11746496
Psychological impact of receiving a BRCA1/BRCA2 test result.
Lodder L, Frets PG, Trijsburg RW, Meijers-Heijboer EJ, Klijn JG, Duivenvoorden HJ, Tibben A, Wagner A, van der Meer CA, van den Ouweland AM, Niermeijer MF
Am J Med Genet. 2001
PubMed ID: 11426450
Frequency of BRCA1 and BRCA2 germline mutations in Japanese breast cancer families.
Ikeda N, Miyoshi Y, Yoneda K, Shiba E, Sekihara Y, Kinoshita M, Noguchi S
Int J Cancer. 2001
PubMed ID: 11149425
Genetic loci controlling breast cancer susceptibility in the Wistar-Kyoto rat.
Lan H, Kendziorski CM, Haag JD, Shepel LA, Newton MA, Gould MN
Genetics. 2001
PubMed ID: 11139513
Lessons learned from BRCA1 and BRCA2.
Zheng L, Li S, Boyer TG, Lee WH
Oncogene. 2000
PubMed ID: 11156530
Identification of a functional nuclear export sequence in BRCA1.
Rodríguez JA, Henderson BR
J Biol Chem. 2000
PubMed ID: 10991937
Tamoxifen and risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. Hereditary Breast Cancer Clinical Study Group.
Narod SA, Brunet JS, Ghadirian P, Robson M, Heimdal K, Neuhausen SL, Stoppa-Lyonnet D, Lerman C, Pasini B, de los Rios P, Weber B, Lynch H, Hereditary Breast Cancer Clinical Study Group
Lancet. 2000
PubMed ID: 11130383
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.
Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, Abraham RT
Genes Dev. 2000
PubMed ID: 11114888
Evaluation of the needs of male carriers of mutations in BRCA1 or BRCA2 who have undergone genetic counseling.
Liede A, Metcalfe K, Hanna D, Hoodfar E, Snyder C, Durham C, Lynch HT, Narod SA
Am J Hum Genet. 2000
PubMed ID: 11063672
BRCA1 physically and functionally interacts with ATF1.
Houvras Y, Benezra M, Zhang H, Manfredi JJ, Weber BL, Licht JD
J Biol Chem. 2000
PubMed ID: 10945975
Expression of Brca1 and splice variant Brca1delta11 RNA levels in mouse mammary gland during normal development and tumorigenesis.
Mixon M, Kittrell F, Medina D
Oncogene. 2000
PubMed ID: 11077440
Uptake of hereditary breast/ovarian cancer genetic testing in a French national sample of BRCA1 families. The French Cancer Genetic Network.
Julian-Reynier C, Sobol H, Sévilla C, Noguès C, Bourret P, French Cancer Genetic Network
Psychooncology. 2000
PubMed ID: 11180585
Factors associated with decisions about clinical BRCA1/2 testing.
Armstrong K, Calzone K, Stopfer J, Fitzgerald G, Coyne J, Weber B
Cancer Epidemiol Biomarkers Prev. 2000
PubMed ID: 11097234
Breast cancer susceptibility gene 1 (BRCAI) is a coactivator of the androgen receptor.
Park JJ, Irvine RA, Buchanan G, Koh SS, Park JM, Tilley WD, Stallcup MR, Press MF, Coetzee GA
Cancer Res. 2000
PubMed ID: 11085509
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
An evaluation of needs of female BRCA1 and BRCA2 carriers undergoing genetic counselling.
Metcalfe KA, Liede A, Hoodfar E, Scott A, Foulkes WD, Narod SA
J Med Genet. 2000
PubMed ID: 11073541
Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases. Anglian Breast Cancer Study Group.

Br J Cancer. 2000
PubMed ID: 11044354
A high occurrence of BRCA1 and BRCA2 mutations among Czech hereditary breast and breast-ovarian cancer families.
Machácková E, Foretová L, Navrátilová M, Valík D, Claes K, Messiaen L
Cas Lek Cesk. 2000
PubMed ID: 11192759
Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells.
Yeh S, Hu YC, Rahman M, Lin HK, Hsu CL, Ting HJ, Kang HY, Chang C
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11016951
Low prevalence of germline BRCA1 mutations in early onset breast cancer without a family history.
Ellis D, Greenman J, Hodgson S, McCall S, Lalloo F, Cameron J, Izatt L, Scott G, Jacobs C, Watts S, Chorley W, Perrett C, Macdermot K, Mohammed S, Evans G, Mathew CG
J Med Genet. 2000
PubMed ID: 11183185
Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1.
Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH
Mol Cell. 2000
PubMed ID: 11090615
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Multiple founder effects and geographical clustering of BRCA1 and BRCA2 families in Finland.
Sarantaus L, Huusko P, Eerola H, Launonen V, Vehmanen P, Rapakko K, Gillanders E, Syrjäkoski K, Kainu T, Vahteristo P, Krahe R, Pääkkönen K, Hartikainen J, Blomqvist C, Löppönen T, Holli K, Ryynänen M, Bützow R, Borg A, Wasteson Arver B, Holmberg E, Mannermaa A, Kere J, Kallioniemi OP, Winqvist R, Nevanlinna H
Eur J Hum Genet. 2000
PubMed ID: 11039575
BAC contig from a 3-cM region of mouse chromosome 11 surrounding Brca1.
Pershouse M, Li J, Yang C, Su H, Brundage E, Di W, Biggs PJ, Bradley A, Chinault AC
Genomics. 2000
PubMed ID: 11013085
Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage.
Chen J
Cancer Res. 2000
PubMed ID: 11016625
A novel human rad54 homologue, Rad54B, associates with Rad51.
Tanaka K, Hiramoto T, Fukuda T, Miyagawa K
J Biol Chem. 2000
PubMed ID: 10851248
Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice.
Lane TF, Lin C, Brown MA, Solomon E, Leder P
Oncogene. 2000
PubMed ID: 10962568
Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines.
Rauh-Adelmann C, Lau KM, Sabeti N, Long JP, Mok SC, Ho SM
Mol Carcinog. 2000
PubMed ID: 10972993
Roles of BRCA1 and its interacting proteins.
Deng CX, Brodie SG
Bioessays. 2000
PubMed ID: 10918303
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM
Curr Biol. 2000
PubMed ID: 10959836
BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer.
Bochar DA, Wang L, Beniya H, Kinev A, Xue Y, Lane WS, Wang W, Kashanchi F, Shiekhattar R
Cell. 2000
PubMed ID: 10943845
Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response.
Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH
Nature. 2000
PubMed ID: 10910365
BRCA2-null embryonic survival is prolonged on the BALB/c genetic background.
Bennett LM, McAllister KA, Blackshear PE, Malphurs J, Goulding G, Collins NK, Ward T, Bunch DO, Eddy EM, Davis BJ, Wiseman RW
Mol Carcinog. 2000
PubMed ID: 10942534
Brcal required for T cell lineage development but not TCR loci rearrangement.
Mak TW, Hakem A, McPherson JP, Shehabeldin A, Zablocki E, Migon E, Duncan GS, Bouchard D, Wakeham A, Cheung A, Karaskova J, Sarosi I, Squire J, Marth J, Hakem R
Nat Immunol. 2000
PubMed ID: 10881179
The exon 13 duplication in the BRCA1 gene is a founder mutation present in geographically diverse populations. The BRCA1 Exon 13 Duplication Screening Group.

Am J Hum Genet. 2000
PubMed ID: 10827109
Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor.
Yu X, Baer R
J Biol Chem. 2000
PubMed ID: 10764811
Role for ATM in DNA damage-induced phosphorylation of BRCA1.
Gatei M, Scott SP, Filippovitch I, Soronika N, Lavin MF, Weber B, Khanna KK
Cancer Res. 2000
PubMed ID: 10866324
Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
Górski B, Byrski T, Huzarski T, Jakubowska A, Menkiszak J, Gronwald J, Pluzańska A, Bebenek M, Fischer-Maliszewska L, Grzybowska E, Narod SA, Lubiński J
Am J Hum Genet. 2000
PubMed ID: 10788334
Initiation of translation from a downstream in-frame AUG codon on BRCA1 can generate the novel isoform protein DeltaBRCA1(17aa).
Liu J, Prolla G, Rostagno A, Chiarle R, Feiner H, Inghirami G
Oncogene. 2000
PubMed ID: 10851077
Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes.
Ouchi T, Lee SW, Ouchi M, Aaronson SA, Horvath CM
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10792030
VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells.
Zhang H, Wang Q, Kajino K, Greene MI
DNA Cell Biol. 2000
PubMed ID: 10855792
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J
Genes Dev. 2000
PubMed ID: 10783165
BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and hRPB10alpha in activated transcription.
Schlegel BP, Green VJ, Ladias JA, Parvin JD
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10725406
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response.
Lee JS, Collins KM, Brown AL, Lee CH, Chung JH
Nature. 2000
PubMed ID: 10724175
Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation.
Deng CX, Scott F
Oncogene. 2000
PubMed ID: 10713690
BRCA1 suppresses insulin-like growth factor-I receptor promoter activity: potential interaction between BRCA1 and Sp1.
Maor SB, Abramovitch S, Erdos MR, Brody LC, Werner H
Mol Genet Metab. 2000
PubMed ID: 10720440
CBP/p300 interact with and function as transcriptional coactivators of BRCA1.
Pao GM, Janknecht R, Ruffner H, Hunter T, Verma IM
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10655477
Papillary serous carcinoma of the peritoneum: analysis of clonality of peritoneal tumors.
Nishimura- M, Wakabayashi M, Hashimoto T, Shibata J, Ueyama H, Ebina M, Fujiyama Y, Bamba T
J Gastroenterol. 2000
PubMed ID: 10905363
Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes.
Meng Q, Qi M, Chen DZ, Yuan R, Goldberg ID, Rosen EM, Auborn K, Fan S
J Mol Med. 2000
PubMed ID: 10868478
Substrate specificities and identification of putative substrates of ATM kinase family members.
Kim ST, Lim DS, Canman CE, Kastan MB
J Biol Chem. 1999
PubMed ID: 10608806
Genetic analysis of BRCA1 function in a defined tumor cell line.
Scully R, Ganesan S, Vlasakova K, Chen J, Socolovsky M, Livingston DM
Mol Cell. 1999
PubMed ID: 10635334
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.
Cortez D, Wang Y, Qin J, Elledge SJ
Science. 1999
PubMed ID: 10550055
Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells.
Altiok S, Batt D, Altiok N, Papautsky A, Downward J, Roberts TM, Avraham H
J Biol Chem. 1999
PubMed ID: 10542266
BRCA1-associated growth arrest is RB-dependent.
Aprelikova ON, Fang BS, Meissner EG, Cotter S, Campbell M, Kuthiala A, Bessho M, Jensen RA, Liu ET
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10518542
The contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer: no evidence for other ovarian cancer-susceptibility genes.
Gayther SA, Russell P, Harrington P, Antoniou AC, Easton DF, Ponder BA
Am J Hum Genet. 1999
PubMed ID: 10486320
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.
Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S, Weissman AM
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10500182
Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.
Kleiman FE, Manley JL
Science. 1999
PubMed ID: 10477523
Identification and genetic mapping of differentially expressed genes in mice differing at the If1 interferon regulatory locus.
Kozak CA, Su Y, Raj NB, Pitha PM
Mamm Genome. 1999
PubMed ID: 10441734
Penetrances of BRCA1 1675delA and 1135insA with respect to breast cancer and ovarian cancer.
Dørum A, Heimdal K, Hovig E, Inganäs M, Møller P
Am J Hum Genet. 1999
PubMed ID: 10441573
Expression of human BRCA1 and BRCA2 proteins in lung from a fetus at 19 weeks' gestation.
Bernard-Gallon DJ, Dechelotte P, Rio PG, Bignon YJ
Int J Cancer. 1999
PubMed ID: 10417779
Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23.
Sagane K, Yamazaki K, Mizui Y, Tanaka I
Gene. 1999
PubMed ID: 10433968
De novo BRCA1 mutation in a patient with breast cancer and an inherited BRCA2 mutation.
Tesoriero A, Andersen C, Southey M, Somers G, McKay M, Armes J, McCredie M, Giles G, Hopper JL, Venter D
Am J Hum Genet. 1999
PubMed ID: 10417300
Common mutations in BRCA1 and BRCA2 do not contribute to early prostate cancer in Jewish men.
Nastiuk KL, Mansukhani M, Terry MB, Kularatne P, Rubin MA, Melamed J, Gammon MD, Ittmann M, Krolewski JJ
Prostate. 1999
PubMed ID: 10398279
Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.
Zhong Q, Chen CF, Li S, Chen Y, Wang CC, Xiao J, Chen PL, Sharp ZD, Lee WH
Science. 1999
PubMed ID: 10426999
Casein kinase 2 binds to and phosphorylates BRCA1.
O'Brien KA, Lemke SJ, Cocke KS, Rao RN, Beckmann RP
Biochem Biophys Res Commun. 1999
PubMed ID: 10403822
Denaturing gradient gel electrophoresis screening of the BRCA1 gene in cells from precancerous cervical lesions.
Park SJ, Chan PJ, Seraj IM, King A
J Reprod Med. 1999
PubMed ID: 10442317
BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site.
Ruffner H, Jiang W, Craig AG, Hunter T, Verma IM
Mol Cell Biol. 1999
PubMed ID: 10373534
BRCA1 inhibition of estrogen receptor signaling in transfected cells.
Fan S, Wang J, Yuan R, Ma Y, Meng Q, Erdos MR, Pestell RG, Yuan F, Auborn KJ, Goldberg ID, Rosen EM
Science. 1999
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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.
Xu X, Wagner KU, Larson D, Weaver Z, Li C, Ried T, Hennighausen L, Wynshaw-Boris A, Deng CX
Nat Genet. 1999
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Germline BRCA1 alterations in a population-based series of ovarian cancer cases.
Janezic SA, Ziogas A, Krumroy LM, Krasner M, Plummer SJ, Cohen P, Gildea M, Barker D, Haile R, Casey G, Anton-Culver H
Hum Mol Genet. 1999
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BRCA1 interacts with components of the histone deacetylase complex.
Yarden RI, Brody LC
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10220405
Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage.
Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD, Lee WH
J Biol Chem. 1999
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Chromosomal localization of the Huntingtin associated protein (HAP-1) gene in mouse and humans with radiation hybrid and interspecific backcross mapping.
Nasir J, Maclean A, Engelender S, Duan K, Margolis RL, Kleiderlein JJ, Ross CA, Hayden MR
Mamm Genome. 1999
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BRCA1 and BRCA2 in breast cancer.
Yang X, Lippman ME
Breast Cancer Res Treat. 1999
PubMed ID: 10369075
Molecular characterization of germline mutations in the BRCA1 and BRCA2 genes from breast cancer families in Taiwan.
Li SS, Tseng HM, Yang TP, Liu CH, Teng SJ, Huang HW, Chen LM, Kao HW, Chen JH, Tseng JN, Chen A, Hou MF, Huang TJ, Chang HT, Mok KT, Tsai JH
Hum Genet. 1999
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Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.
Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW, Harris CC, Ried T, Deng CX
Mol Cell. 1999
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Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1.
Meza JE, Brzovic PS, King MC, Klevit RE
J Biol Chem. 1999
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The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.
Irminger-Finger I, Siegel BD, Leung WC
Biol Chem. 1999
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Screening for germ-line rearrangements and regulatory mutations in BRCA1 led to the identification of four new deletions.
Puget N, Stoppa-Lyonnet D, Sinilnikova OM, Pagès S, Lynch HT, Lenoir GM, Mazoyer S
Cancer Res. 1999
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The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter.
Chai YL, Cui J, Shao N, Shyam E, Reddy P, Rao VN
Oncogene. 1999
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Mammary tumor formation in p53- and BRCA1-deficient mice.
Cressman VL, Backlund DC, Hicks EM, Gowen LC, Godfrey V, Koller BH
Cell Growth Differ. 1999
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Sequence analysis of the rat Brca1 homolog and its promoter region.
Bennett LM, Brownlee HA, Hagavik S, Wiseman RW
Mamm Genome. 1999
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Carninci P, Hayashizaki Y
Methods Enzymol. 1999
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Ghebranious N, Donehower LA
Oncogene. 1998
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A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.
Shen SX, Weaver Z, Xu X, Li C, Weinstein M, Chen L, Guan XY, Ried T, Deng CX
Oncogene. 1998
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cDNA sequence and chromosomal localization of mouse Dlgh3 gene adjacent to the BRCA1 tumor suppressor locus.
Lin L, Peters LL, Ciciotte SL, Chishti AH
Biochim Biophys Acta. 1998
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Characterization of a carboxy-terminal BRCA1 interacting protein.
Wong AK, Ormonde PA, Pero R, Chen Y, Lian L, Salada G, Berry S, Lawrence Q, Dayananth P, Ha P, Tavtigian SV, Teng DH, Bartel PL
Oncogene. 1998
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Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11.
Liu P, Zhang H, McLellan A, Vogel H, Bradley A
Genetics. 1998
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BRCA1 is associated with the centrosome during mitosis.
Hsu LC, White RL
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9789027
Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein.
Ayi TC, Tsan JT, Hwang LY, Bowcock AM, Baer R
Oncogene. 1998
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BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells.
Wang Q, Zhang H, Kajino K, Greene MI
Oncogene. 1998
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BRCA1 gene mutations in women with papillary serous carcinoma of the peritoneum.
Bandera CA, Muto MG, Schorge JO, Berkowitz RS, Rubin SC, Mok SC
Obstet Gynecol. 1998
PubMed ID: 9764635
The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression.
Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R
J Biol Chem. 1998
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Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.
Chen J, Silver DP, Walpita D, Cantor SB, Gazdar AF, Tomlinson G, Couch FJ, Weber BL, Ashley T, Livingston DM, Scully R
Mol Cell. 1998
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Oral contraceptives and the risk of hereditary ovarian cancer. Hereditary Ovarian Cancer Clinical Study Group.
Narod SA, Risch H, Moslehi R, Dørum A, Neuhausen S, Olsson H, Provencher D, Radice P, Evans G, Bishop S, Brunet JS, Ponder BA
N Engl J Med. 1998
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A high proportion of mutations in the BRCA1 gene in German breast/ovarian cancer families with clustering of mutations in the 3' third of the gene.
Dong J, Chang-Claude J, Wu Y, Schumacher V, Debatin I, Tonin P, Royer-Pokora B
Hum Genet. 1998
PubMed ID: 9760198
An alternative splice site junction in exon 1a of the BRCA1 gene.
Fetzer S, Tworek HA, Piver MS, Dicioccio RA
Cancer Genet Cytogenet. 1998
PubMed ID: 9689938
BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
Anderson SF, Schlegel BP, Nakajima T, Wolpin ES, Parvin JD
Nat Genet. 1998
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Molecular evidence for multifocal papillary serous carcinoma of the peritoneum in patients with germline BRCA1 mutations.
Schorge JO, Muto MG, Welch WR, Bandera CA, Rubin SC, Bell DA, Berkowitz RS, Mok SC
J Natl Cancer Inst. 1998
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A breast cancer patient of Scottish descent with germ-line mutations in BRCA1 and BRCA2.
Liede A, Rehal P, Vesprini D, Jack E, Abrahamson J, Narod SA
Am J Hum Genet. 1998
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The cancer-predisposing mutation C61G disrupts homodimer formation in the NH2-terminal BRCA1 RING finger domain.
Brzovic PS, Meza J, King MC, Klevit RE
J Biol Chem. 1998
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BRCA1 physically associates with p53 and stimulates its transcriptional activity.
Zhang H, Somasundaram K, Peng Y, Tian H, Zhang H, Bi D, Weber BL, El-Deiry WS
Oncogene. 1998
PubMed ID: 9582019
Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs.
Li S, Ku CY, Farmer AA, Cong YS, Chen CF, Lee WH
J Biol Chem. 1998
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BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression.
Jensen DE, Proctor M, Marquis ST, Gardner HP, Ha SI, Chodosh LA, Ishov AM, Tommerup N, Vissing H, Sekido Y, Minna J, Borodovsky A, Schultz DC, Wilkinson KD, Maul GG, Barlev N, Berger SL, Prendergast GC, Rauscher FJ
Oncogene. 1998
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BRCA1 regulates p53-dependent gene expression.
Ouchi T, Monteiro AN, August A, Aaronson SA, Hanafusa H
Proc Natl Acad Sci U S A. 1998
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BRCA1: a review of structure and putative functions.
Paterson JW
Dis Markers. 1998
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Factors associated with the mammalian RNA polymerase II holoenzyme.
Neish AS, Anderson SF, Schlegel BP, Wei W, Parvin JD
Nucleic Acids Res. 1998
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Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice.
Blackshear PE, Goldsworthy SM, Foley JF, McAllister KA, Bennett LM, Collins NK, Bunch DO, Brown P, Wiseman RW, Davis BJ
Oncogene. 1998
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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.
de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG
Proc Natl Acad Sci U S A. 1998
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High proportion of missense mutations of the BRCA1 and BRCA2 genes in Japanese breast cancer families.
Katagiri T, Kasumi F, Yoshimoto M, Nomizu T, Asaishi K, Abe R, Tsuchiya A, Sugano M, Takai S, Yoneda M, Fukutomi T, Nanba K, Makita M, Okazaki H, Hirata K, Okazaki M, Furutsuma Y, Morishita Y, Iino Y, Karino T, Ayabe H, Hara S, Kajiwara T, Houga S, Miki Y
J Hum Genet. 1998
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Constant denaturant gel electrophoresis (CDGE) in BRCA1 mutation screening.
Andersen TI, Eiken HG, Couch F, Kaada G, Skrede M, Johnsen H, Aloysius TA, Tveit KM, Tranebjaerg L, Dørum A, Møller P, Weber BL, Børresen-Dale AL
Hum Mutat. 1998
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Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains.
Jin Y, Xu XL, Yang MC, Wei F, Ayi TC, Bowcock AM, Baer R
Proc Natl Acad Sci U S A. 1997
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Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage.
Scully R, Chen J, Ochs RL, Keegan K, Hoekstra M, Feunteun J, Livingston DM
Cell. 1997
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BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases.
Wang H, Shao N, Ding QM, Cui J, Reddy ES, Rao VN
Oncogene. 1997
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BRCA1 is a cell cycle-regulated nuclear phosphoprotein.
Ruffner H, Verma IM
Proc Natl Acad Sci U S A. 1997
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Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.
Hakem R, de la Pompa JL, Elia A, Potter J, Mak TW
Nat Genet. 1997
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BRCA1 is a component of the RNA polymerase II holoenzyme.
Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD
Proc Natl Acad Sci U S A. 1997
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Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases. Breast Cancer Linkage Consortium.

Lancet. 1997
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Physical and linkage mapping of human chromosome 17 loci to dog chromosomes 9 and 5.
Werner P, Raducha MG, Prociuk U, Henthorn PS, Patterson DF
Genomics. 1997
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Brca2 is required for embryonic cellular proliferation in the mouse.
Suzuki A, de la Pompa JL, Hakem R, Elia A, Yoshida R, Mo R, Nishina H, Chuang T, Wakeham A, Itie A, Koo W, Billia P, Ho A, Fukumoto M, Hui CC, Mak TW
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Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.
Ludwig T, Chapman DL, Papaioannou VE, Efstratiadis A
Genes Dev. 1997
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Frequently occurring germ-line mutations of the BRCA1 gene in ovarian cancer families from Russia.
Gayther SA, Harrington P, Russell P, Kharkevich G, Garkavtseva RF, Ponder BA
Am J Hum Genet. 1997
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Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues.
Rajan JV, Marquis ST, Gardner HP, Chodosh LA
Dev Biol. 1997
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An MMTV integration site maps near the distal end of mouse chromosome 11.
Rajan L, Dudley JP
Mamm Genome. 1997
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Brca1 is expressed independently of hormonal stimulation in the mouse ovary.
Phillips KW, Goldsworthy SM, Bennett LM, Brownlee HA, Wiseman RW, Davis BJ
Lab Invest. 1997
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Mutations and alternative splicing of the BRCA1 gene in UK breast/ovarian cancer families.
Xu CF, Chambers JA, Nicolai H, Brown MA, Hujeirat Y, Mohammed S, Hodgson S, Kelsell DP, Spurr NK, Bishop DT, Solomon E
Genes Chromosomes Cancer. 1997
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Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene.
Connor F, Smith A, Wooster R, Stratton M, Dixon A, Campbell E, Tait TM, Freeman T, Ashworth A
Hum Mol Genet. 1997
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Common BRCA1 variants and susceptibility to breast and ovarian cancer in the general population.
Dunning AM, Chiano M, Smith NR, Dearden J, Gore M, Oakes S, Wilson C, Stratton M, Peto J, Easton D, Clayton D, Ponder BA
Hum Mol Genet. 1997
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Association of BRCA1 with Rad51 in mitotic and meiotic cells.
Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston DM
Cell. 1997
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Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b.
Wilson CA, Payton MN, Elliott GS, Buaas FW, Cajulis EE, Grosshans D, Ramos L, Reese DM, Slamon DJ, Calzone FJ
Oncogene. 1997
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Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit.
Kohda K, Matsuda Y, Ishibashi T, Tanaka K, Kasahara M
Immunogenetics. 1997
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PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes.
Kandil E, Kohda K, Ishibashi T, Tanaka K, Kasahara M
Immunogenetics. 1997
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Localization of BRCA1 and a splice variant identifies the nuclear localization signal.
Thakur S, Zhang HB, Peng Y, Le H, Carroll B, Ward T, Yao J, Farid LM, Couch FJ, Wilson RB, Weber BL
Mol Cell Biol. 1997
PubMed ID: 8972225
The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor.
Chen CF, Li S, Chen Y, Chen PL, Sharp ZD, Lee WH
J Biol Chem. 1996
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Isolation of the murine Nbr1 gene adjacent to the murine Brca1 gene.
Chambers JA, Solomon E
Genomics. 1996
PubMed ID: 8975707
Identification of a RING protein that can interact in vivo with the BRCA1 gene product.
Wu LC, Wang ZW, Tsan JT, Spillman MA, Phung A, Xu XL, Yang MC, Hwang LY, Bowcock AM, Baer R
Nat Genet. 1996
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Evidence for a transcriptional activation function of BRCA1 C-terminal region.
Monteiro AN, August A, Hanafusa H
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8942979
Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells.
Rajan JV, Wang M, Marquis ST, Chodosh LA
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8917547
Subcellular localization and analysis of apparent 180-kDa and 220-kDa proteins of the breast cancer susceptibility gene, BRCA1.
Thomas JE, Smith M, Rubinfeld B, Gutowski M, Beckmann RP, Polakis P
J Biol Chem. 1996
PubMed ID: 8910495
Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1.
Smith TM, Lee MK, Szabo CI, Jerome N, McEuen M, Taylor M, Hood L, King MC
Genome Res. 1996
PubMed ID: 8938427
BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogen.
Spillman MA, Bowcock AM
Oncogene. 1996
PubMed ID: 8895509
Characterization of functional messenger RNA splice variants of BRCA1 expressed in nonmalignant and tumor-derived breast cells.
Lu M, Conzen SD, Cole CN, Arrick BA
Cancer Res. 1996
PubMed ID: 8840964
Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences.
Makałowski W, Zhang J, Boguski MS
Genome Res. 1996
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Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
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Human, canine and murine BRCA1 genes: sequence comparison among species.
Szabo CI, Wagner LA, Francisco LV, Roach JC, Argonza R, King MC, Ostrander EA
Hum Mol Genet. 1996
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Cloning, genetic mapping and expression studies of the rat Brca1 gene.
Chen KS, Shepel LA, Haag JD, Heil GM, Gould MN
Carcinogenesis. 1996
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BRCA1 mRNA is expressed highly during meiosis and spermiogenesis but not during mitosis of male germ cells.
Zabludoff SD, Wright WW, Harshman K, Wold BJ
Oncogene. 1996
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A common BRCA1 mutation in Norwegian breast and ovarian cancer families?
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Am J Hum Genet. 1996
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BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner.
Chen Y, Farmer AA, Chen CF, Jones DC, Chen PL, Lee WH
Cancer Res. 1996
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Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.
Liu CY, Flesken-Nikitin A, Li S, Zeng Y, Lee WH
Genes Dev. 1996
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Koonin EV, Altschul SF, Bork P
Nat Genet. 1996
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The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.
Hakem R, de la Pompa JL, Sirard C, Mo R, Woo M, Hakem A, Wakeham A, Potter J, Reitmair A, Billia F, Firpo E, Hui CC, Roberts J, Rossant J, Mak TW
Cell. 1996
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The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21.
Brown MA, Xu CF, Nicolai H, Griffiths B, Chambers JA, Black D, Solomon E
Oncogene. 1996
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Comparison of BRCA1 polymorphisms, rare sequence variants and/or missense mutations in unaffected and breast/ovarian cancer populations.
Durocher F, Shattuck-Eidens D, McClure M, Labrie F, Skolnick MH, Goldgar DE, Simard J
Hum Mol Genet. 1996
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Langston AA, Stanford JL, Wicklund KG, Thompson JD, Blazej RG, Ostrander EA
Am J Hum Genet. 1996
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Genetic mapping of the Brca1 gene on mouse chromosome 11.
DeGregorio L, Harshman K, Rosenthal J, Dragani TA, Pierotti MA
Mamm Genome. 1996
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Founding BRCA1 mutations in hereditary breast and ovarian cancer in southern Sweden.
Johannsson O, Ostermeyer EA, Håkansson S, Friedman LS, Johansson U, Sellberg G, Brøndum-Nielsen K, Sele V, Olsson H, King MC, Borg A
Am J Hum Genet. 1996
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BRCA1 is secreted and exhibits properties of a granin.
Jensen RA, Thompson ME, Jetton TL, Szabo CI, van der Meer R, Helou B, Tronick SR, Page DL, King MC, Holt JT
Nat Genet. 1996
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Growth retardation and tumour inhibition by BRCA1.
Holt JT, Thompson ME, Szabo C, Robinson-Benion C, Arteaga CL, King MC, Jensen RA
Nat Genet. 1996
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Antisense RNA to the putative tumor suppressor gene BRCA1 transforms mouse fibroblasts.
Rao VN, Shao N, Ahmad M, Reddy ES
Oncogene. 1996
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The murine homolog of the human breast and ovarian cancer susceptibility gene Brca1 maps to mouse chromosome 11D.
Schröck E, Badger P, Larson D, Erdos M, Wynshaw-Boris A, Ried T, Brody L
Hum Genet. 1996
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Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities.
Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH
Nat Genet. 1996
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Annu Rev Genet. 1996
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BRCA1 R841W: a strong candidate for a common mutation with moderate phenotype.
Barker DF, Almeida ER, Casey G, Fain PR, Liao SY, Masunaka I, Noble B, Kurosaki T, Anton-Culver H
Genet Epidemiol. 1996
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Hum Mutat. 1996
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Katagiri T, Emi M, Ito I, Kobayashi K, Yoshimoto M, Iwase T, Kasumi F, Miki Y, Skolnick MH, Nakamura Y
Hum Mutat. 1996
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A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families.
Serova O, Montagna M, Torchard D, Narod SA, Tonin P, Sylla B, Lynch HT, Feunteun J, Lenoir GM
Am J Hum Genet. 1996
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Chromosome engineering in mice.
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Nature. 1995
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Sharan SK, Wims M, Bradley A
Hum Mol Genet. 1995
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Mouse Brca1: localization sequence analysis and identification of evolutionarily conserved domains.
Abel KJ, Xu J, Yin GY, Lyons RH, Meisler MH, Weber BL
Hum Mol Genet. 1995
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Distinct transcription start sites generate two forms of BRCA1 mRNA.
Xu CF, Brown MA, Chambers JA, Griffiths B, Nicolai H, Solomon E
Hum Mol Genet. 1995
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Novel inherited mutations and variable expressivity of BRCA1 alleles, including the founder mutation 185delAG in Ashkenazi Jewish families.
Friedman LS, Szabo CI, Ostermeyer EA, Dowd P, Butler L, Park T, Lee MK, Goode EL, Rowell SE, King MC
Am J Hum Genet. 1995
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Aberrant subcellular localization of BRCA1 in breast cancer.
Chen Y, Chen CF, Riley DJ, Allred DC, Chen PL, Von Hoff D, Osborne CK, Lee WH
Science. 1995
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Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice.
Lane TF, Deng C, Elson A, Lyu MS, Kozak CA, Leder P
Genes Dev. 1995
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Isolation of the mouse homologue of BRCA1 and genetic mapping to mouse chromosome 11.
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Genomics. 1995
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The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals.
Struewing JP, Abeliovich D, Peretz T, Avishai N, Kaback MM, Collins FS, Brody LC
Nat Genet. 1995
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The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues.
Marquis ST, Rajan JV, Wynshaw-Boris A, Xu J, Yin GY, Abel KJ, Weber BL, Chodosh LA
Nat Genet. 1995
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Merajver SD, Pham TM, Caduff RF, Chen M, Poy EL, Cooney KA, Weber BL, Collins FS, Johnston C, Frank TS
Nat Genet. 1995
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Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families.
Friedman LS, Ostermeyer EA, Szabo CI, Dowd P, Lynch ED, Rowell SE, King MC
Nat Genet. 1994
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Simard J, Tonin P, Durocher F, Morgan K, Rommens J, Gingras S, Samson C, Leblanc JF, Bélanger C, Dion F
Nat Genet. 1994
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Castilla LH, Couch FJ, Erdos MR, Hoskins KF, Calzone K, Garber JE, Boyd J, Lubin MB, Deshano ML, Brody LC
Nat Genet. 1994
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Lancet. 1994
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Gastroenterology. 1991
PubMed ID: 2001833
Linkage of early-onset familial breast cancer to chromosome 17q21.
Hall JM, Lee MK, Newman B, Morrow JE, Anderson LA, Huey B, King MC
Science. 1990
PubMed ID: 2270482
[Myoglobinuria caused by McArdle's disease complicated by anuric acute renal insufficiency]
Chanard J, Kleinknecht D, Dreyfus JC, Fardeau M, Kaplan M
Arch Fr Pediatr. 1972
PubMed ID: 4506230
The publication is not currently in our database, click on the link below to see it on pubmed.
PubMed ID:

Model Organism Phenotype Links from MGI Top Help

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	Human	Mouse	Rat
Entrez Gene	672	12189	497672
EnsEMBL Gene(s)	ENSG00000012048	ENSMUSG00000017146	ENSRNOG00000020701
Unigene	Hs.194143	Mm.244975	Rn.217584
Homologene	BRCA1	Brca1	Brca1
OMIM	113705	N/A	N/A
GeneCards	BRCA1	N/A	N/A
Beta Cell Genomics	DT.100785657 DT.100785659 DT.100785660 DT.102831055 DT.120969413 DT.120969426 DT.313524 DT.91764293 DT.91764294	DT.101407283 DT.529940	N/A
Reactome	P38398	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	672	12189	497672

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
BRCA1	RAD50	IntAct, BioGRID	empirical	16260778 10783165 11504724 10426999 16391231
BRCA1	CDK2	HPRD, BioGRID	empirical	10373534 8764100 9244350
BRCA1	CDK4	HPRD, BioGRID, Reactome	empirical	9244350 17334399 17541404 9008167 17981954 16123081 9311981 18535008 9826763 10562567 20062530 15164066
BRCA1	CDK5	BioGRID	empirical	9244350
BRCA1	CDK7	HPRD	empirical	15282296
BRCA1	CDK8	BioGRID	empirical	9159119
BRCA1	CDKN2D	BioGRID	empirical	17334399
BRCA1	CDS1	BioGRID	empirical	12438214
BRCA1	TADA3	IntAct	empirical	16260778
BRCA1	UBE2E3	BioGRID	empirical	19712108 17873885
BRCA1	MORF4L1	BioGRID	empirical	20332121
BRCA1	TOPBP1	BioGRID	empirical	16391231
BRCA1	CHEK1	IntAct	empirical	11836499
BRCA1	DMC1	Reactome	predicted	17541404 9008167 17981954 16123081 9311981 18535008 9826763 10562567 20062530 15164066
BRCA1	CHEK2	HPRD, IntAct	empirical	10724175 12111733 17525332
BRCA1	OLIG1	BioGRID	empirical	20211142
BRCA1	CREB1	MINT, BioGRID	empirical	9926942 10945975
BRCA1	CREBBP	HPRD, BioGRID	empirical	10655477 9926942 12700228 11782371 9443979 16860316
BRCA1	CTCFL	BioGRID	empirical	14578343
BRCA1	DYNLL2	Sanger Interaction Map	predicted	15345047
BRCA1	CSNK2A1	HPRD, BioGRID	empirical	10403822
BRCA1	CSNK2B	HPRD, BioGRID	empirical	10403822
BRCA1	CSTF1	HPRD, BioGRID	empirical	11278247 11257228
BRCA1	CSTF2	IntAct, BioGRID	empirical	10477523 11257228
BRCA1	CTBP1	HPRD, BioGRID	empirical	10196224
BRCA1	DHX9	HPRD, BioGRID	empirical	12592385 9662397
BRCA1	E2F1	HPRD	empirical	9244350 11278247
BRCA1	E2F4	HPRD, BioGRID	empirical	9244350
BRCA1	ELK1	HPRD	empirical	11313879
BRCA1	ELK4	BioGRID	empirical	11313879
BRCA1	EP300	HPRD, BioGRID	empirical	10655477 11782371 19887647
BRCA1	AKT1	HPRD, IntAct, BioGRID	empirical	10542266 21242970 19074868
BRCA1	ESR1	HPRD, MINT, IntAct, BioGRID	empirical	10334989 11244506 12400015 15674350 11493692 11782371 16860316 16260778 16061635 20060929 19887647
BRCA1	ETS1	BioGRID	empirical	11313879
BRCA1	EWSR1	BioGRID	empirical	20211142
BRCA1	ALDH1A1	HPRD	empirical	00001
BRCA1	FANCA	HPRD, MINT	empirical	12354784
BRCA1	FANCD2	HPRD, MINT, BioGRID	empirical	11239454 14499622 12887909
BRCA1	FHL2	HPRD, MINT, IntAct, BioGRID	empirical	14550570 21988832 14986435
BRCA1	FOXO3	BioGRID	empirical	18344987
BRCA1	KIF1B	BioGRID	empirical	14578343
BRCA1	FLI1	BioGRID	empirical	11313879
BRCA1	ORC3	IntAct	empirical	17525332
BRCA1	KPNA6	HPRD	empirical	8955125
BRCA1	ABL1	HPRD, MINT, BioGRID	empirical	12024016 17352427
BRCA1	COBRA1	HPRD, IntAct, BioGRID	empirical	12612062 11739404
BRCA1	KAT2A	IntAct, BioGRID	empirical	16260778
BRCA1	NUFIP1	HPRD, BioGRID	empirical	15107825
BRCA1	BABAM1	BioGRID	empirical	19261749 19261746
BRCA1	UBE2T	BioGRID	empirical	19887602
BRCA1	BRD7	BioGRID	empirical	20215511
BRCA1	MSH6	IntAct, BioGRID	empirical	16260778 11498787 10783165
BRCA1	GTF2E1	BioGRID	empirical	9159119
BRCA1	GTF2F1	BioGRID	empirical	9159119
BRCA1	GTF2H4	BioGRID	empirical	9159119
BRCA1	H2AFX	HPRD, IntAct, BioGRID	empirical	12419185 18001825 18001824 12485996 10959836 11927591 19805520 18344987
BRCA1	HDAC1	HPRD, BioGRID	empirical	10220405
BRCA1	HDAC2	HPRD, BioGRID	empirical	10220405
BRCA1	UBE2K	BioGRID	empirical	19712108 17873885
BRCA1	HIVEP1	IntAct	empirical	21988832
BRCA1	ACACA	HPRD, IntAct, BioGRID	empirical	12360400 16326698 19061860
BRCA1	HOXA2	BioGRID	empirical	20211142
BRCA1	HOXC12	BioGRID	empirical	20211142
BRCA1	PRMT1	BioGRID	empirical	20614009
BRCA1	HSPA8	BioGRID	empirical	9738006
BRCA1	HSPD1	IntAct	empirical	21988832
BRCA1	IFI16	HPRD	empirical	14654789
BRCA1	AR	HPRD	empirical	11016951 11085509
BRCA1	JAK1	HPRD, MINT, BioGRID	empirical	11163768
BRCA1	JAK2	HPRD, MINT, BioGRID	empirical	11163768
BRCA1	JUN	HPRD, BioGRID	empirical	12080089
BRCA1	JUNB	HPRD, BioGRID	empirical	12080089
BRCA1	JUND	HPRD, BioGRID	empirical	12080089
BRCA1	JUP	IntAct	empirical	21988832
BRCA1	KPNA1	MINT	empirical	8955125
BRCA1	KPNA2	HPRD, IntAct, BioGRID	empirical	9497340 8955125
BRCA1	ARNT	BioGRID	empirical	16567799
BRCA1	SMAD2	HPRD	empirical	15735739
BRCA1	SMAD3	HPRD, BioGRID	empirical	15735739
BRCA1	SMAD4	HPRD	empirical	15735739
BRCA1	MAP3K3	HPRD, BioGRID	empirical	15205325
BRCA1	MLH1	HPRD, BioGRID	empirical	10783165 17148452 21240188
BRCA1	MNAT1	HPRD	empirical	15282296
BRCA1	MSH2	IntAct, BioGRID	empirical	16260778 11498787 10783165 15886699
BRCA1	MSH3	BioGRID	empirical	14578343 11498787
BRCA1	MYC	HPRD, BioGRID	empirical	9788437 12646176 11916966 14612409 20215511
BRCA1	ATF1	HPRD, BioGRID	empirical	10945975
BRCA1	NBN	HPRD, BioGRID	empirical	10426999 10783165 11504724 19244116
BRCA1	NCK1	IntAct	empirical	17474147
BRCA1	ATM	HPRD, Reactome	empirical	10550055 10866324 11114888 17541404 9008167 17981954 16123081 9311981 18535008 9826763 10562567 20062530 15164066
BRCA1	NFKB1	HPRD	empirical	12700228
BRCA1	NFYA	HPRD, BioGRID	empirical	11777930
BRCA1	NPM1	BioGRID	empirical	15184379
BRCA1	ORC2	BioGRID	empirical	17525332
BRCA1	UBXN1	BioGRID	empirical	20351172
BRCA1	CDK16	BioGRID	empirical	9738006
BRCA1	UBE2J1	IntAct, BioGRID	empirical	19690564
BRCA1	PIAS4	BioGRID	empirical	20016603 20016594
BRCA1	UIMC1	IntAct, BioGRID	empirical	17525340 19615732 17525342 17525341 21622030 19261748
BRCA1	PEG3	BioGRID	empirical	11746496
BRCA1	PGR	BioGRID	empirical	21531767
BRCA1	PIK3R1	IntAct	empirical	17474147
BRCA1	POLR2A	HPRD, BioGRID	empirical	10725406 14506230 12955082 9159119 11504724 15886201
BRCA1	POLR2H	BioGRID	empirical	17283126
BRCA1	POLR2K	HPRD	empirical	10725406
BRCA1	ATR	HPRD, BioGRID	empirical	11114888 11278964 10608806 11016625 17478428 15589157
BRCA1	POU2F1	HPRD, BioGRID	empirical	11777930 18000219
BRCA1	MED1	HPRD, BioGRID	empirical	15208681
BRCA1	PPP1CA	HPRD, IntAct, BioGRID	empirical	12438214 17511879
BRCA1	PPP1CB	IntAct, BioGRID	empirical	17511879
BRCA1	PPP1CC	IntAct	empirical	17511879
BRCA1	PPP1R3A	BioGRID	empirical	17511879
BRCA1	UBE2W	BioGRID	empirical	19712108 17873885
BRCA1	ZCCHC8	IntAct, BioGRID	empirical	17525332
BRCA1	POMGNT1	IntAct	empirical	21988832
BRCA1	PRKDC	BioGRID	empirical	10608806
BRCA1	PSAP	HPRD	empirical	11313879
BRCA1	BACH1	BioGRID	empirical	11301010 17664283 15125843 16391231
BRCA1	WDR48	IntAct, BioGRID	empirical	19615732
BRCA1	BARD1	HPRD, MINT, IntAct, BioGRID, Sanger Interaction Map	empirical	8944023 10026184 11773071 12431996 11573085 15265711 11278247 15184379 12438698 9342365 12419249 10477523 11498787 12485996 12890688 11925436 14647430 12732733 14638690 14636569 11504724 11257228 11526114 11927591 15159397 9738006 10635334 12951069 12700228 11301010 9788437 19176389 19117993 17525341 20215511 16489000 18936166 17664283 20060929 16391231 20351172 21901007 15345047
BRCA1	PEX5	IntAct	empirical	21988832
BRCA1	RAD23B	MINT	empirical	16712842
BRCA1	RAD51	HPRD, BioGRID, Reactome	empirical	9774970 9008167 14636569 11498787 17541404 17981954 16123081 9311981 18535008 9826763 10562567 20062530 15164066
BRCA1	RB1	HPRD, BioGRID	empirical	10220405 10518542 11521194
BRCA1	RBBP4	HPRD, BioGRID	empirical	10220405
BRCA1	RBBP7	HPRD, BioGRID	empirical	10220405 11394910 11746496
BRCA1	RBBP8	HPRD, IntAct, BioGRID	empirical	9738006 10196224 9811458 17525340 11739404 14578343 10910365 11689934 10764811 17525342 16818604 20351172
BRCA1	RBL2	BioGRID	empirical	11521194
BRCA1	ZNF350	HPRD, IntAct, BioGRID	empirical	11090615
BRCA1	CCND1	HPRD, IntAct, BioGRID	empirical	9244350 17334399
BRCA1	RELA	HPRD, BioGRID	empirical	12700228
BRCA1	RFC1	HPRD, BioGRID	empirical	10783165
BRCA1	RPA1	BioGRID	empirical	21240188
BRCA1	RPL31	BioGRID	empirical	11746496
BRCA1	CLSPN	HPRD, BioGRID	empirical	15096610
BRCA1	BLM	BioGRID	empirical	10783165
BRCA1	DCLRE1C	HPRD	empirical	15456891
BRCA1	SMARCA2	HPRD, BioGRID	empirical	15034933 15574597
BRCA1	SMARCA4	HPRD, BioGRID	empirical	10943845 15034933
BRCA1	SMARCB1	BioGRID	empirical	10943845
BRCA1	SMARCC1	BioGRID	empirical	10943845
BRCA1	SMARCC2	BioGRID	empirical	10943845
BRCA1	SMARCD2	BioGRID	empirical	10943845
BRCA1	SUMO3	BioGRID	empirical	21147198
BRCA1	SP1	HPRD, BioGRID	empirical	10720440 14710355 12706836
BRCA1	SRC	BioGRID	empirical	16860316
BRCA1	BRCA1	HPRD, IntAct, BioGRID	empirical	12611903 11751867 9159119 555 8944023 14578343 11573086 9525870 16818604 20351172 21965653
BRCA1	BRCA2	HPRD, BioGRID, Reactome	empirical	9774970 11477095 20211142 19369211 17541404 9008167 17981954 16123081 9311981 18535008 9826763 10562567 20062530 15164066
BRCA1	STAT1	HPRD, BioGRID	empirical	10792030
BRCA1	STAT3	HPRD	empirical	11163768
BRCA1	STAT5A	HPRD, BioGRID	empirical	12459499
BRCA1	AURKA	HPRD, BioGRID	empirical	14990569
BRCA1	TAF9	IntAct	empirical	16260778
BRCA1	TAF10	IntAct	empirical	16260778
BRCA1	TERF1	BioGRID	empirical	19797051
BRCA1	TERF2	BioGRID	empirical	19797051
BRCA1	TOP2A	HPRD, BioGRID	empirical	15965487
BRCA1	TP53	HPRD, MINT, BioGRID	empirical	9482880 9926942 14710355 9582019 14978302 14636569
BRCA1	TP53BP1	HPRD, IntAct, BioGRID	empirical	12364621 17525332 18001824 21552324
BRCA1	TUBA4A	HPRD	empirical	12353262
BRCA1	TUBB2A	HPRD	empirical	12353262
BRCA1	TUBG1	HPRD, BioGRID	empirical	11691781 9789027 15367667
BRCA1	UBB	HPRD	empirical	11320250
BRCA1	UBC	BioGRID	empirical	17525341 17185394 15665273 17218787 19887602 20631078 20351172 21965653 21890473 21906983
BRCA1	UBA1	BioGRID	empirical	12485996 14638690 12438698 11927591 11278247
BRCA1	UBE2D1	BioGRID	empirical	12485996 12732733 14638690 12438698 11927591 14636569 12890688 11278247 19712108
BRCA1	UBE2D2	BioGRID	empirical	21113135 19712108
BRCA1	UBE2D3	HPRD, BioGRID	empirical	12732733 16628214 21113135 19712108
BRCA1	UBE2E1	BioGRID	empirical	19712108 17873885
BRCA1	UBE2E2	BioGRID	empirical	19712108 17873885
BRCA1	UBE2I	BioGRID	empirical	20016594
BRCA1	UBE2L3	HPRD, BioGRID	empirical	12732733 19712108
BRCA1	UBE2N	BioGRID	empirical	19712108 17873885
BRCA1	USF2	HPRD, BioGRID	empirical	14502648
BRCA1	VCP	HPRD, BioGRID	empirical	10855792
BRCA1	WNT2B	BioGRID	empirical	11746496
BRCA1	XRCC1	HPRD	empirical	11352725
BRCA1	XRCC5	BioGRID	empirical	18936166
BRCA1	YY1	HPRD	empirical	11777930
BRCA1	BRCC3	HPRD, BioGRID	empirical	14636569 17664283
BRCA1	PALB2	BioGRID, Reactome	empirical	19584259 19553677 19268590 19369211
BRCA1	SMC1A	HPRD, MINT, IntAct, BioGRID	empirical	11877377
BRCA1	TRRAP	HPRD, IntAct, BioGRID	empirical	16260778
BRCA1	BAP1	HPRD, IntAct	empirical	9528852
BRCA1	BRAP	HPRD, MINT, IntAct, BioGRID	empirical	9497340 8955125
BRCA1	GFI1B	HPRD, MINT, IntAct	empirical	16713569
BRCA1	HIST2H2AC	BioGRID	empirical	11927591
BRCA1	CASP3	HPRD	empirical	12149654
BRCA1	BRIP1	HPRD, MINT, IntAct	empirical	11301010 15242590 11877378 14576432 17581638 17525340
BRCA1	FAM175A	HPRD, IntAct, BioGRID	empirical	17525340 19261749 19261746 21282113 19261748
BRCA1	ANTXR1	HPRD	empirical	20566643
BRCA1	SUPT3H	IntAct	empirical	16260778
BRCA1	LMO4	HPRD, BioGRID	empirical	11751867 12925972
BRCA1	PIAS1	BioGRID	empirical	20016603 20016594
BRCA1	TRIM24	IntAct	empirical	21988832
BRCA1	CCNA2	HPRD, BioGRID	empirical	9244350 10373534
BRCA1	CCNA1	HPRD, BioGRID	empirical	10373534 9244350
BRCA1	CCNB1	HPRD, BioGRID	empirical	9244350 11278247
BRCA1	HERC2	BioGRID	empirical	20631078
BRCA1	CCNE1	IntAct, BioGRID	empirical	17525332
BRCA1	RNF8	IntAct	empirical	18001825
BRCA1	DNAJA3	BioGRID	empirical	14578343
BRCA1	NMI	HPRD, BioGRID	empirical	11916966
BRCA1	MTA2	BioGRID	empirical	19703393
BRCA1	MED21	HPRD, BioGRID	empirical	9159119
BRCA1	MED23	BioGRID	empirical	15208681
BRCA1	MED17	BioGRID	empirical	11504724 15208681 12154023
BRCA1	MAP4K4	BioGRID	empirical	14578343
BRCA1	H2AFY	HPRD	empirical	12419249
BRCA1	BRE	BioGRID	empirical	14636569
BRCA1	MDC1	HPRD, IntAct, BioGRID	empirical	12607005 17525332 21622030
BRCA1	CDK1	HPRD, BioGRID	empirical	9244350
BRCA1	MED24	BioGRID	empirical	15208681
BRCA1	MED13	BioGRID	empirical	15208681
BRCA1	NUP153	BioGRID	empirical	14578343