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SLC16A1

Gene Description:   solute carrier family 16 (monocarboxylic acid transporters), member 1; solute carrier family 16, member 1 (monocarboxylic acid transporter 1) Synonyms:   MCT, Mct1, FLJ36745, RNMCT1, HHF7, SLC16A1, MGC44475, Slc16a1, MCT1, AL022710, RATMCT1 Orthologs:   Human SLC16A1 (protein-coding), Mouse Slc16a1 (protein-coding), Rat Slc16a1 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid, KEGG Human-Rat: HomoloGene, MGD, RGD, Inparanoid, KEGG Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid, KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Mouse: 1 Rat: 3

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Iddm3	Rat	chr2:197256223..242256223	45.00	285
Idd18.2	Mouse	chr3:100949733..108222063	7.27	124

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm26	Rat	chr2:181710214..222281918	40.57	506

(Human) GRCh37 - chr1:113454469..113499635 (45.17 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr3:104442591..104462385 (19.79 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr2:199860321..199880646 (20.32 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for SLC16A1: The SLC16A1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs SLC16A1   SERINC3   IntAct, BioGRID  empirical  17353931  SLC16A1   AP1S1   IntAct, BioGRID  empirical  17353931  SLC16A1   MME   IntAct  empirical  17342744  SLC16A1   BSG   HPRD, BioGRID  empirical  10921872  SLC16A1   TRAF6   IntAct  empirical  17353931  SLC16A1   UBC   BioGRID  empirical  16196087  SLC16A1   MAP1LC3B   IntAct  empirical  20562859  SLC16A1   DEGS1   IntAct, BioGRID  empirical  17353931  SLC16A1   TSC22D1   IntAct  empirical  17353931

View all

KEGG Network: None available   None available.

Biocarta: None available   None available.

Reactome: 10   Basigin interactions REACT_12560 Bile salt and organic anion SLC transporters REACT_20633 Cell surface interactions at the vascular wall REACT_12051 Hemostasis REACT_604 Proton-coupled monocarboxylate transport REACT_20515 Pyruvate metabolism REACT_2071 Pyruvate metabolism and Citric Acid (TCA) cycle REACT_1046 SLC-mediated transmembrane transport REACT_19118 Transmembrane transport of small molecules REACT_15518 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds REACT_19305

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 15   Membrane fraction GO:0005624 Mitochondrion GO:0005739 Plasma membrane GO:0005886 Pyruvate metabolic process GO:0006090 Blood coagulation GO:0007596 Monocarboxylic acid transmembrane transporter activity GO:0008028 Mevalonate transmembrane transporter activity GO:0015130 Symporter activity GO:0015293 Secondary active monocarboxylate transmembrane transporter activity GO:0015355 Organic anion transport GO:0015711 Monocarboxylic acid transport GO:0015718 Mevalonate transport GO:0015728 Integral to membrane GO:0016021 Leukocyte migration GO:0050900 Transmembrane transport GO:0055085

	KEGG Network: None available
	Biocarta: None available
	Reactome: 10 Basigin interactions REACT_12560 Bile salt and organic anion SLC transporters REACT_20633 Cell surface interactions at the vascular wall REACT_12051 Hemostasis REACT_604 Proton-coupled monocarboxylate transport REACT_20515 Pyruvate metabolism REACT_2071 Pyruvate metabolism and Citric Acid (TCA) cycle REACT_1046 SLC-mediated transmembrane transport REACT_19118 Transmembrane transport of small molecules REACT_15518 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds REACT_19305
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 15 Membrane fraction GO:0005624 Mitochondrion GO:0005739 Plasma membrane GO:0005886 Pyruvate metabolic process GO:0006090 Blood coagulation GO:0007596 Monocarboxylic acid transmembrane transporter activity GO:0008028 Mevalonate transmembrane transporter activity GO:0015130 Symporter activity GO:0015293 Secondary active monocarboxylate transmembrane transporter activity GO:0015355 Organic anion transport GO:0015711 Monocarboxylic acid transport GO:0015718 Mevalonate transport GO:0015728 Integral to membrane GO:0016021 Leukocyte migration GO:0050900 Transmembrane transport GO:0055085

Type 1 Diabetes Publications: 2

• miR-29a and miR-29b contribute to pancreatic {beta}-cell specific silencing of Monocarboxylate Transporter 1 (Mct1/slc16a1).
  Pullen TJ, da Silva Xavier G, Kelsey G, Rutter GA
  Mol Cell Biol. 2011
  PubMed ID: 21646425
   
  
• Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells.
  Otonkoski T, Jiao H, Kaminen-Ahola N, Tapia-Paez I, Ullah MS, Parton LE, Schuit F, Quintens R, Sipilä I, Mayatepek E, Meissner T, Halestrap AP, Rutter GA, Kere J
  Am J Hum Genet. 2007
  PubMed ID: 17701893
   
  

Publications: 148

• Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells.
  Izumi H, Takahashi M, Uramoto H, Nakayama Y, Oyama T, Wang KY, Sasaguri Y, Nishizawa S, Kohno K
  Cancer Sci. 2011
  PubMed ID: 21306479
   
  
• Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1beta via late phase activation of nuclear factor kappaB and expression of phagocyte-type NADPH oxidase.
  Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, Takami M, Suzawa T, Tsunawaki S, Tachikawa T, Baba K, Kamijo R
  J Biol Chem. 2011
  PubMed ID: 21372137
   
  
• A transient placental source of serotonin for the fetal forebrain.
  Bonnin A, Goeden N, Chen K, Wilson ML, King J, Shih JC, Blakely RD, Deneris ES, Levitt P
  Nature. 2011
  PubMed ID: 21512572
   
  
• Astrocyte-neuron lactate transport is required for long-term memory formation.
  Suzuki A, Stern SA, Bozdagi O, Huntley GW, Walker RH, Magistretti PJ, Alberini CM
  Cell. 2011
  PubMed ID: 21376239
   
  
• Mild experimental ketosis increases brain uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats.
  Pifferi F, Tremblay S, Croteau E, Fortier M, Tremblay-Mercier J, Lecomte R, Cunnane SC
  Nutr Neurosci. 2011
  PubMed ID: 21605500
   
  
• Control of MCT1 function in cerebrovascular endothelial cells by intracellular pH.
  Uhernik AL, Tucker C, Smith JP
  Brain Res. 2011
  PubMed ID: 21192921
   
  
• Effects of Phellinus linteus administration on serotonin synthesis in the brain and expression of monocarboxylate transporters in the muscle during exhaustive exercise in rats.
  Seo JH, Sung YH, Kim KJ, Shin MS, Lee EK, Kim CJ
  J Nutr Sci Vitaminol (Tokyo). 2011
  PubMed ID: 21512297
   
  
• MCT expression and lactate influx/efflux in tanycytes involved in glia-neuron metabolic interaction.
  Cortés-Campos C, Elizondo R, Llanos P, Uranga RM, Nualart F, García MA
  PLoS One. 2011
  PubMed ID: 21297988
   
  
• Initial characterization of the human central proteome.
  Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
  BMC Syst Biol. 2011
  PubMed ID: 21269460
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
  Diabetes Care. 2010
  PubMed ID: 20628086
   
  
• MCT1 genetic polymorphism influence in high intensity circuit training: a pilot study.
  Cupeiro R, Benito PJ, Maffulli N, Calderón FJ, González-Lamuño D
  J Sci Med Sport. 2010
  PubMed ID: 19850519
   
  
• Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis.
  Becker HM, Mohebbi N, Perna A, Ganapathy V, Capasso G, Wagner CA
  Am J Physiol Renal Physiol. 2010
  PubMed ID: 20392797
   
  
• Characterization of monocarboxylate transporter 1 (MCT1) binding affinity for Basigin gene products and L1cam.
  Howard J, Finch NA, Ochrietor JD
  Cell Mol Neurobiol. 2010
  PubMed ID: 20155396
   
  
• Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma.
  Pinheiro C, Albergaria A, Paredes J, Sousa B, Dufloth R, Vieira D, Schmitt F, Baltazar F
  Histopathology. 2010
  PubMed ID: 20636790
   
  
• Monocarboxylate transport in human corneal epithelium and cell lines.
  Vellonen KS, Häkli M, Merezhinskaya N, Tervo T, Honkakoski P, Urtti A
  Eur J Pharm Sci. 2010
  PubMed ID: 20035863
   
  
• Cellular expression of the monocarboxylate transporter (MCT) family in the placenta of mice.
  Nagai A, Takebe K, Nio-Kobayashi J, Takahashi-Iwanaga H, Iwanaga T
  Placenta. 2010
  PubMed ID: 20022372
   
  
• AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.
  Ovens MJ, Davies AJ, Wilson MC, Murray CM, Halestrap AP
  Biochem J. 2010
  PubMed ID: 19929853
   
  
• The involvement of intracellular calcium in the MCT-mediated uptake of lactic acid by HeLa cells.
  Cheeti S, Lee CH
  Mol Pharm. 2010
  PubMed ID: 19905008
   
  
• Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes.
  Pérez de Heredia F, Wood IS, Trayhurn P
  Pflugers Arch. 2010
  PubMed ID: 19876643
   
  
• Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
  PLoS One. 2010
  PubMed ID: 20877624
   
  
• Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44.
  Pinheiro C, Reis RM, Ricardo S, Longatto-Filho A, Schmitt F, Baltazar F
  J Biomed Biotechnol. 2010
  PubMed ID: 20454640
   
  
• Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.
  Ross CJ, Katzov-Eckert H, Dubé MP, Brooks B, Rassekh SR, Barhdadi A, Feroz-Zada Y, Visscher H, Brown AM, Rieder MJ, Rogers PC, Phillips MS, Carleton BC, Hayden MR, CPNDS Consortium
  Nat Genet. 2009
  PubMed ID: 19898482
   
  
• Mechanisms underlying modulation of monocarboxylate transporter 1 (MCT1) by somatostatin in human intestinal epithelial cells.
  Saksena S, Theegala S, Bansal N, Gill RK, Tyagi S, Alrefai WA, Ramaswamy K, Dudeja PK
  Am J Physiol Gastrointest Liver Physiol. 2009
  PubMed ID: 20501436
   
  
• Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
  Am J Hum Genet. 2009
  PubMed ID: 19913121
   
  
• Hydrophobic interactions stabilize the basigin-MCT1 complex.
  Finch NA, Linser PJ, Ochrietor JD
  Protein J. 2009
  PubMed ID: 19760495
   
  
• miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1.
  Li KK, Pang JC, Ching AK, Wong CK, Kong X, Wang Y, Zhou L, Chen Z, Ng HK
  Hum Pathol. 2009
  PubMed ID: 19427019
   
  
• Increased expression of monocarboxylate transporter 1 after acute ischemia of isolated, perfused mouse hearts.
  Martinov V, Rizvi SM, Weiseth SA, Sagave J, Bergersen LH, Valen G
  Life Sci. 2009
  PubMed ID: 19604494
   
  
• Increased densities of monocarboxylate transport protein MCT1 after chronic administration of nicotine in rat brain.
  Canis M, Mack B, Gires O, Maurer MH, Kuschinsky W, Duembgen L, Duelli R
  Neurosci Res. 2009
  PubMed ID: 19433117
   
  
• Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle.
  Wilson MC, Meredith D, Bunnun C, Sessions RB, Halestrap AP
  J Biol Chem. 2009
  PubMed ID: 19473976
   
  
• Enhanced cerebral expression of MCT1 and MCT2 in a rat ischemia model occurs in activated microglial cells.
  Moreira TJ, Pierre K, Maekawa F, Repond C, Cebere A, Liljequist S, Pellerin L
  J Cereb Blood Flow Metab. 2009
  PubMed ID: 19401710
   
  
• Large-scale proteomics analysis of the human kinome.
  Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
  Mol Cell Proteomics. 2009
  PubMed ID: 19369195
   
  
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
  Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
  Anal Chem. 2009
  PubMed ID: 19413330
   
  
• Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
  Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ
  Mol Cell Proteomics. 2009
  PubMed ID: 19131326
   
  
• Dietary pectin up-regulates monocaboxylate transporter 1 in the rat gastrointestinal tract.
  Kirat D, Kondo K, Shimada R, Kato S
  Exp Physiol. 2009
  PubMed ID: 19168540
   
  
• Cellular expression of a monocarboxylate transporter (MCT1) in the mammary gland and sebaceous gland of mice.
  Takebe K, Nio-Kobayashi J, Takahashi-Iwanaga H, Yajima T, Iwanaga T
  Histochem Cell Biol. 2009
  PubMed ID: 19048272
   
  
• Increased densities of monocarboxylate transporter MCT1 after chronic hyperglycemia in rat brain.
  Canis M, Maurer MH, Kuschinsky W, Duembgen L, Duelli R
  Brain Res. 2009
  PubMed ID: 19118535
   
  
• PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2.
  Saksena S, Dwivedi A, Gill RK, Singla A, Alrefai WA, Malakooti J, Ramaswamy K, Dudeja PK
  Am J Physiol Gastrointest Liver Physiol. 2009
  PubMed ID: 19033536
   
  
• Genetic variations in the MCT1 (SLC16A1) gene in the Chinese population of Singapore.
  Lean CB, Lee EJ
  Drug Metab Pharmacokinet. 2009
  PubMed ID: 19881260
   
  
• The phagosomal proteome in interferon-gamma-activated macrophages.
  Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P
  Immunity. 2009
  PubMed ID: 19144319
   
  
• Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.
  Wang B, Malik R, Nigg EA, Körner R
  Anal Chem. 2008
  PubMed ID: 19007248
   
  
• Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
  Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
  J Proteome Res. 2008
  PubMed ID: 19367708
   
  
• Histochemical demonstration of a monocarboxylate transporter in the mouse perineurium with special reference to GLUT1.
  Takebe K, Nio-Kobayashi J, Takahashi-Iwanaga H, Iwanaga T
  Biomed Res. 2008
  PubMed ID: 19129673
   
  
• Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
  Sonveaux P, Végran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, De Saedeleer CJ, Kennedy KM, Diepart C, Jordan BF, Kelley MJ, Gallez B, Wahl ML, Feron O, Dewhirst MW
  J Clin Invest. 2008
  PubMed ID: 19033663
   
  
• Effects of high-intensity training on muscle lactate transporters and postexercise recovery of muscle lactate and hydrogen ions in women.
  Bishop D, Edge J, Thomas C, Mercier J
  Am J Physiol Regul Integr Comp Physiol. 2008
  PubMed ID: 18832090
   
  
• Basal and stimulated lactate fluxes in primary cultures of astrocytes are differentially controlled by distinct proteins.
  Maekawa F, Minehira K, Kadomatsu K, Pellerin L
  J Neurochem. 2008
  PubMed ID: 18761711
   
  
• Cellular expression of a sodium-dependent monocarboxylate transporter (Slc5a8) and the MCT family in the mouse kidney.
  Yanase H, Takebe K, Nio-Kobayashi J, Takahashi-Iwanaga H, Iwanaga T
  Histochem Cell Biol. 2008
  PubMed ID: 18751721
   
  
• Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
  Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
  Genome Res. 2008
  PubMed ID: 18799693
   
  
• PGC-1alpha increases skeletal muscle lactate uptake by increasing the expression of MCT1 but not MCT2 or MCT4.
  Benton CR, Yoshida Y, Lally J, Han XX, Hatta H, Bonen A
  Physiol Genomics. 2008
  PubMed ID: 18523157
   
  
• Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.
  Zhou H, Ye M, Dong J, Han G, Jiang X, Wu R, Zou H
  J Proteome Res. 2008
  PubMed ID: 18630941
   
  
• Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
  Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
  Mol Cell. 2008
  PubMed ID: 18691976
   
  
• A quantitative atlas of mitotic phosphorylation.
  Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
  Proc Natl Acad Sci U S A. 2008
  PubMed ID: 18669648
   
  
• Nonenzymatic proton handling by carbonic anhydrase II during H+-lactate cotransport via monocarboxylate transporter 1.
  Becker HM, Deitmer JW
  J Biol Chem. 2008
  PubMed ID: 18539591
   
  
• A mitochondrial protein compendium elucidates complex I disease biology.
  Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK
  Cell. 2008
  PubMed ID: 18614015
   
  
• Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha.
  König B, Koch A, Giggel K, Dordschbal B, Eder K, Stangl GI
  Biochim Biophys Acta. 2008
  PubMed ID: 18375207
   
  
• Effect of weight loss on lactate transporter expression in skeletal muscle of obese subjects.
  Metz L, Mercier J, Tremblay A, Alméras N, Joanisse DR
  J Appl Physiol. 2008
  PubMed ID: 18079261
   
  
• Toward a confocal subcellular atlas of the human proteome.
  Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
  Mol Cell Proteomics. 2008
  PubMed ID: 18029348
   
  
• Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas.
  Pinheiro C, Longatto-Filho A, Scapulatempo C, Ferreira L, Martins S, Pellerin L, Rodrigues M, Alves VA, Schmitt F, Baltazar F
  Virchows Arch. 2008
  PubMed ID: 18188595
   
  
• Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: influence of chronic metabolic alkalosis.
  Thomas C, Bishop D, Moore-Morris T, Mercier J
  Am J Physiol Endocrinol Metab. 2007
  PubMed ID: 17609257
   
  
• Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice.
  Pierre K, Parent A, Jayet PY, Halestrap AP, Scherrer U, Pellerin L
  J Physiol. 2007
  PubMed ID: 17599960
   
  
• Phosphorylation of MCT-1 by p44/42 MAPK is required for its stabilization in response to DNA damage.
  Nandi S, Reinert LS, Hachem A, Mazan-Mamczarz K, Hagner P, He H, Gartenhaus RB
  Oncogene. 2007
  PubMed ID: 17016429
   
  
• Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.
  Lee J, Xu Y, Chen Y, Sprung R, Kim SC, Xie S, Zhao Y
  Mol Cell Proteomics. 2007
  PubMed ID: 17208939
   
  
• Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
  Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM
  Mol Cell Proteomics. 2007
  PubMed ID: 17114649
   
  
• High-intensity exercise acutely decreases the membrane content of MCT1 and MCT4 and buffer capacity in human skeletal muscle.
  Bishop D, Edge J, Thomas C, Mercier J
  J Appl Physiol. 2007
  PubMed ID: 17082373
   
  
• Large-scale phosphorylation analysis of mouse liver.
  Villén J, Beausoleil SA, Gerber SA, Gygi SP
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17242355
   
  
• The full-ORF clone resource of the German cDNA Consortium.
  Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blöcker H, Heubner D, Hoerlein A, Michel G, Wedler H, Köhrer K, Ottenwälder B, Poustka A, Wiemann S, Schupp I
  BMC Genomics. 2007
  PubMed ID: 17974005
   
  
• Large-scale mapping of human protein-protein interactions by mass spectrometry.
  Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
  Mol Syst Biol. 2007
  PubMed ID: 17353931
   
  
• Monocarboxylate transporter 1 mediates DL-2-Hydroxy-(4-methylthio)butanoic acid transport across the apical membrane of Caco-2 cell monolayers.
  Martín-Venegas R, Rodríguez-Lagunas MJ, Geraert PA, Ferrer R
  J Nutr. 2007
  PubMed ID: 17182800
   
  
• Testosterone increases lactate transport, monocarboxylate transporter (MCT) 1 and MCT4 in rat skeletal muscle.
  Enoki T, Yoshida Y, Lally J, Hatta H, Bonen A
  J Physiol. 2006
  PubMed ID: 16959859
   
  
• Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
  Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
  Cell. 2006
  PubMed ID: 17081983
   
  
• The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity.
  Manoharan C, Wilson MC, Sessions RB, Halestrap AP
  Mol Membr Biol. 2006
  PubMed ID: 17127621
   
  
• Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: evidence of a mitochondrial lactate oxidation complex.
  Hashimoto T, Hussien R, Brooks GA
  Am J Physiol Endocrinol Metab. 2006
  PubMed ID: 16434551
   
  
• The DNA sequence and biological annotation of human chromosome 1.
  Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E
  Nature. 2006
  PubMed ID: 16710414
   
  
• Tissue distribution of basigin and monocarboxylate transporter 1 in the adult male mouse: a study using the wild-type and basigin gene knockout mice.
  Nakai M, Chen L, Nowak RA
  Anat Rec A Discov Mol Cell Evol Biol. 2006
  PubMed ID: 16612830
   
  
• IGF-I receptor gene activation enhanced the expression of monocarboxylic acid transporter 1 in hepatocarcinoma cells.
  Kang KW, Jin MJ, Han HK
  Biochem Biophys Res Commun. 2006
  PubMed ID: 16516162
   
  
• The effects of short-term sprint training on MCT expression in moderately endurance-trained runners.
  Bickham DC, Bentley DJ, Le Rossignol PF, Cameron-Smith D
  Eur J Appl Physiol. 2006
  PubMed ID: 16408234
   
  
• Glucose affects monocarboxylate cotransporter (MCT) 1 expression during mouse preimplantation development.
  Jansen S, Esmaeilpour T, Pantaleon M, Kaye PL
  Reproduction. 2006
  PubMed ID: 16514190
   
  
• Expression of the monocarboxylate transporter MCT1 in the adult human brain cortex.
  Chiry O, Pellerin L, Monnet-Tschudi F, Fishbein WN, Merezhinskaya N, Magistretti PJ, Clarke S
  Brain Res. 2006
  PubMed ID: 16403470
   
  
• Modulation of monocarboxylic acid transporter-1 kinetic function by the cAMP signaling pathway in rat brain endothelial cells.
  Smith JP, Drewes LR
  J Biol Chem. 2006
  PubMed ID: 16301311
   
  
• Cross-reinnervation changes the expression patterns of the monocarboxylate transporters 1 and 4: An experimental study in slow and fast rat skeletal muscle.
  Bergersen LH, Thomas M, Jóhannsson E, Waerhaug O, Halestrap A, Andersen K, Sejersted OM, Ottersen OP
  Neuroscience. 2006
  PubMed ID: 16446038
   
  
• Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS.
  Moser K, White FM
  J Proteome Res. 2006
  PubMed ID: 16396499
   
  
• Enteropathogenic Escherichia coli inhibits butyrate uptake in Caco-2 cells by altering the apical membrane MCT1 level.
  Borthakur A, Gill RK, Hodges K, Ramaswamy K, Hecht G, Dudeja PK
  Am J Physiol Gastrointest Liver Physiol. 2006
  PubMed ID: 16150873
   
  
• Transport activity of MCT1 expressed in Xenopus oocytes is increased by interaction with carbonic anhydrase.
  Becker HM, Hirnet D, Fecher-Trost C, Sültemeyer D, Deitmer JW
  J Biol Chem. 2005
  PubMed ID: 16174776
   
  
• Does higher red blood cell (RBC) lactate transporter activity explain impaired RBC deformability in sickle cell trait?
  Connes P, Sara F, Hardy-Dessources MD, Etienne-Julan M, Hue O
  Jpn J Physiol. 2005
  PubMed ID: 16441976
   
  
• Monocarboxylate transporter MCT1 is a target for immunosuppression.
  Murray CM, Hutchinson R, Bantick JR, Belfield GP, Benjamin AD, Brazma D, Bundick RV, Cook ID, Craggs RI, Edwards S, Evans LR, Harrison R, Holness E, Jackson AP, Jackson CG, Kingston LP, Perry MW, Ross AR, Rugman PA, Sidhu SS, Sullivan M, Taylor-Fishwick DA, Walker PC, Whitehead YM, Wilkinson DJ, Wright A, Donald DK
  Nat Chem Biol. 2005
  PubMed ID: 16370372
   
  
• Expression and membrane localization of MCT isoforms along the length of the human intestine.
  Gill RK, Saksena S, Alrefai WA, Sarwar Z, Goldstein JL, Carroll RE, Ramaswamy K, Dudeja PK
  Am J Physiol Cell Physiol. 2005
  PubMed ID: 15901598
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Immunohistochemical analysis of MCT1, MCT2 and MCT4 expression in rat plantaris muscle.
  Hashimoto T, Masuda S, Taguchi S, Brooks GA
  J Physiol. 2005
  PubMed ID: 15932892
   
  
• Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70).
  Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP
  J Biol Chem. 2005
  PubMed ID: 15917240
   
  
• Functional activity of a monocarboxylate transporter, MCT1, in the human retinal pigmented epithelium cell line, ARPE-19.
  Majumdar S, Gunda S, Pal D, Mitra AK
  Mol Pharm. 2005
  PubMed ID: 15804185
   
  
• The human colonic monocarboxylate transporter Isoform 1: its potential importance to colonic tissue homeostasis.
  Cuff M, Dyer J, Jones M, Shirazi-Beechey S
  Gastroenterology. 2005
  PubMed ID: 15765403
   
  
• Proteomic analysis of in vivo phosphorylated synaptic proteins.
  Collins MO, Yu L, Coba MP, Husi H, Campuzano I, Blackstock WP, Choudhary JS, Grant SG
  J Biol Chem. 2005
  PubMed ID: 15572359
   
  
• Interaction with antigen-specific T cells regulates expression of the lactate transporter MCT1 in primary rat astrocytes: specific link between immunity and homeostasis.
  Korn T, Magnus T, Jung S
  Glia. 2005
  PubMed ID: 15390096
   
  
• Exercise rapidly increases expression of the monocarboxylate transporters MCT1 and MCT4 in rat muscle.
  Coles L, Litt J, Hatta H, Bonen A
  J Physiol. 2004
  PubMed ID: 15388779
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
  Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S
  Genome Res. 2004
  PubMed ID: 15342556
   
  
• Genomic analysis of mouse retinal development.
  Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
  PLoS Biol. 2004
  PubMed ID: 15226823
   
  
• Relationship between skeletal muscle MCT1 and accumulated exercise during voluntary wheel running.
  Yoshida Y, Hatta H, Kato M, Enoki T, Kato H, Bonen A
  J Appl Physiol. 2004
  PubMed ID: 15107415
   
  
• Polarized lactate transporter activity and expression in the syncytiotrophoblast of the term human placenta.
  Settle P, Mynett K, Speake P, Champion E, Doughty IM, Sibley CP, D'Souza SW, Glazier J
  Placenta. 2004
  PubMed ID: 15135232
   
  
• Developmental analyses of 5A11/Basigin, 5A11/Basigin-2 and their putative binding partner MCT1 in the mouse eye.
  Clamp MF, Ochrietor JD, Moroz TP, Linser PJ
  Exp Eye Res. 2004
  PubMed ID: 15037112
   
  
• Effects of strength training on muscle lactate release and MCT1 and MCT4 content in healthy and type 2 diabetic humans.
  Juel C, Holten MK, Dela F
  J Physiol. 2004
  PubMed ID: 14724187
   
  
• The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.
  Halestrap AP, Meredith D
  Pflugers Arch. 2004
  PubMed ID: 12739169
   
  
• Correlation between local monocarboxylate transporter 1 (MCT1) and glucose transporter 1 (GLUT1) densities in the adult rat brain.
  Maurer MH, Canis M, Kuschinsky W, Duelli R
  Neurosci Lett. 2004
  PubMed ID: 14729246
   
  
• Complete sequencing and characterization of 21,243 full-length human cDNAs.
  Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
  Nat Genet. 2004
  PubMed ID: 14702039
   
  
• The loop between helix 4 and helix 5 in the monocarboxylate transporter MCT1 is important for substrate selection and protein stability.
  Galić S, Schneider HP, Bröer A, Deitmer JW, Bröer S
  Biochem J. 2003
  PubMed ID: 12946269
   
  
• Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
  Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 14610273
   
  
• Developmental switch in brain nutrient transporter expression in the rat.
  Vannucci SJ, Simpson IA
  Am J Physiol Endocrinol Metab. 2003
  PubMed ID: 14534079
   
  
• Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain.
  Baud O, Fayol L, Gressens P, Pellerin L, Magistretti P, Evrard P, Verney C
  J Comp Neurol. 2003
  PubMed ID: 12966567
   
  
• Monocarboxylate transporter 1 mediates biotin uptake in human peripheral blood mononuclear cells.
  Daberkow RL, White BR, Cederberg RA, Griffin JB, Zempleni J
  J Nutr. 2003
  PubMed ID: 12949353
   
  
• T3 increases lactate transport and the expression of MCT4, but not MCT1, in rat skeletal muscle.
  Wang Y, Tonouchi M, Miskovic D, Hatta H, Bonen A
  Am J Physiol Endocrinol Metab. 2003
  PubMed ID: 12900382
   
  
• Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures.
  Debernardi R, Pierre K, Lengacher S, Magistretti PJ, Pellerin L
  J Neurosci Res. 2003
  PubMed ID: 12836157
   
  
• Exercise training alleviates MCT1 and MCT4 reductions in heart and skeletal muscles of STZ-induced diabetic rats.
  Enoki T, Yoshida Y, Hatta H, Bonen A
  J Appl Physiol. 2003
  PubMed ID: 12611763
   
  
• Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells.
  Philp NJ, Wang D, Yoon H, Hjelmeland LM
  Invest Ophthalmol Vis Sci. 2003
  PubMed ID: 12657613
   
  
• Reduced expression of GNA11 and silencing of MCT1 in human breast cancers.
  Asada K, Miyamoto K, Fukutomi T, Tsuda H, Yagi Y, Wakazono K, Oishi S, Fukui H, Sugimura T, Ushijima T
  Oncology. 2003
  PubMed ID: 12759536
   
  
• BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
  Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
  Nucleic Acids Res. 2003
  PubMed ID: 12520002
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
  Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
  Proc Natl Acad Sci U S A. 2002
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• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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