SLC2A4

Summary Top Help

Gene Description:

solute carrier family 2 (facilitated glucose transporter), member 4

Synonyms:

Glut4, GLUT4, SLC2A4, Glut-4, Slc2a4

Orthologs:

Human SLC2A4 (protein-coding), Mouse Slc2a4 (protein-coding), Rat Slc2a4 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr17:7185053..7191576 (6.52 kb) View in Genome Browser

(Mouse) NCBIM37 - chr11:69755788..69761692 (5.90 kb) View in Genome Browser

(Rat) RGSC3.4 - chr10:56786705..56792254 (5.55 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for SLC2A4:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for SLC2A4:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 3

Biocarta: 3

Reactome: 7

NCI-Nature Pathway Interaction Database: 3

Gene Ontology: 35

Publications from PubMed Top Help

Type 1 Diabetes Publications: 14

Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues.
Lin HV, Ren H, Samuel VT, Lee HY, Lu TY, Shulman GI, Accili D
Diabetes. 2011
PubMed ID: 21266328
α3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues.
Huang G, Ge G, Wang D, Gopalakrishnan B, Butz DH, Colman RJ, Nagy A, Greenspan DS
J Clin Invest. 2011
PubMed ID: 21293061
DHEA improves impaired activation of Akt and PKC zeta/lambda-GLUT4 pathway in skeletal muscle and improves hyperglycemia in streptozotocin-induced diabetes rats.
Sato K, Iemitsu M, Aizawa K, Ajisaka R
Acta Physiol (Oxf). 2009
PubMed ID: 19523145
Anti-diabetic effects of new herbal formula in neonatally streptozotocin-induced diabetic rats.
Kim JO, Lee GD, Kwon JH, Kim KS
Biol Pharm Bull. 2009
PubMed ID: 19252289
The diabetogenic effects of excessive ethanol: reducing beta-cell mass, decreasing phosphatidylinositol 3-kinase activity and GLUT-4 expression in rats.
Zhao LN, Hao LP, Yang XF, Ying CJ, Yu D, Sun XF
Br J Nutr. 2008
PubMed ID: 18959809
Regulation of insulin secretion and GLUT4 trafficking by the calcium sensor synaptotagmin VII.
Li Y, Wang P, Xu J, Gorelick F, Yamazaki H, Andrews N, Desir GV
Biochem Biophys Res Commun. 2007
PubMed ID: 17720139
Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis.
Brissova M, Blaha M, Spear C, Nicholson W, Radhika A, Shiota M, Charron MJ, Wright CV, Powers AC
Am J Physiol Endocrinol Metab. 2005
PubMed ID: 15562255
The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function.
Scheepers A, Joost HG, Schürmann A
JPEN J Parenter Enteral Nutr. 2004
PubMed ID: 15449578
Regulation of hepatic GLUT8 expression in normal and diabetic models.
Gorovits N, Cui L, Busik JV, Ranalletta M, Hauguel de-Mouzon S, Charron MJ
Endocrinology. 2003
PubMed ID: 12697674
Effect of GLP-1 treatment on GLUT2 and GLUT4 expression in type 1 and type 2 rat diabetic models.
Villanueva-Peñacarrillo ML, Puente J, Redondo A, Clemente F, Valverde I
Endocrine. 2001
PubMed ID: 11720253
Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of Type II diabetes mellitus; NSY mouse.
Ueda H, Ikegami H, Kawaguchi Y, Fujisawa T, Nojima K, Babaya N, Yamada K, Shibata M, Yamato E, Ogihara T
Diabetologia. 2000
PubMed ID: 10952468
Metabolism of d-glucose and its pentaacetate ester in muscles and pancreatic islets of GLUT4 null mice.
Ladrière L, Charron MJ, Malaisse WJ
Biochem Biophys Res Commun. 1999
PubMed ID: 10544020
Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation.
Buse JB, Yasuda K, Lay TP, Seo TS, Olson AL, Pessin JE, Karam JH, Seino S, Bell GI
Diabetes. 1992
PubMed ID: 1397719
Glucose transporter gene expression in early mouse embryos.
Hogan A, Heyner S, Charron MJ, Copeland NG, Gilbert DJ, Jenkins NA, Thorens B, Schultz GA
Development. 1991
PubMed ID: 1765007

Publications: 554

Inhibition of the protein tyrosine phosphatase SHP-1 increases glucose uptake in skeletal muscle cells by augmenting insulin receptor signaling and GLUT4 expression.
Bergeron S, Dubois MJ, Bellmann K, Schwab M, Larochelle N, Nalbantoglu J, Marette A
Endocrinology. 2011
PubMed ID: 21952243
Glucose transporters GLUT4 and GLUT8 are upregulated after facial nerve axotomy in adult mice.
Gómez O, Ballester-Lurbe B, Mesonero JE, Terrado J
J Anat. 2011
PubMed ID: 21740425
N-glycosylation is critical for the stability and intracellular trafficking of glucose transporter GLUT4.
Haga Y, Ishii K, Suzuki T
J Biol Chem. 2011
PubMed ID: 21757715
GLUT4 gene polymorphisms and their association with type 2 diabetes in south Indians.
Bodhini D, Radha V, Ghosh S, Majumder PP, Rao MR, Mohan V
Diabetes Technol Ther. 2011
PubMed ID: 21668369
Perturbations of the stress-induced GLUT4 localization pathway in slow-twitch muscles of obese Zucker rats.
Chen YC, Lee SD, Hsih SY, Hsu YP, Kuo CH, Ho LT
J Physiol Biochem. 2011
PubMed ID: 21347724
Effects of GLUT4 expression on insulin resistance in patients with advanced liver cirrhosis.
Shan WF, Chen BQ, Zhu SJ, Jiang L, Zhou YF
J Zhejiang Univ Sci B. 2011
PubMed ID: 21796809
Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes.
Steinbusch LK, Schwenk RW, Ouwens DM, Diamant M, Glatz JF, Luiken JJ
Cell Mol Life Sci. 2011
PubMed ID: 21547502
MEF2A binding to the Glut4 promoter occurs via an AMPKα2-dependent mechanism.
Gong H, Xie J, Zhang N, Yao L, Zhang Y
Med Sci Sports Exerc. 2011
PubMed ID: 21233771
Loss of AS160 Akt substrate causes Glut4 protein to accumulate in compartments that are primed for fusion in basal adipocytes.
Brewer PD, Romenskaia I, Kanow MA, Mastick CC
J Biol Chem. 2011
PubMed ID: 21613213
Interaction between insulin and estradiol in regulation of cardiac glucose and free fatty acid transporters.
Tepavcevic S, Koricanac G, Zakula Z, Milosavljevic T, Stojiljkovic M, Isenovic ER
Horm Metab Res. 2011
PubMed ID: 21773965
Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes.
Zhu S, Sun F, Li W, Cao Y, Wang C, Wang Y, Liang D, Zhang R, Zhang S, Wang H, Cao F
Mol Cell Biochem. 2011
PubMed ID: 21461612
Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor.
Gonzalez E, Flier E, Molle D, Accili D, McGraw TE
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21646544
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
Park SY, Jin W, Woo JR, Shoelson SE
J Biol Chem. 2011
PubMed ID: 21454505
Dual-mode of insulin action controls GLUT4 vesicle exocytosis.
Xu Y, Rubin BR, Orme CM, Karpikov A, Yu C, Bogan JS, Toomre DK
J Cell Biol. 2011
PubMed ID: 21555461
Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C.
Sano H, Peck GR, Kettenbach AN, Gerber SA, Lienhard GE
J Biol Chem. 2011
PubMed ID: 21454697
AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane.
Koumanov F, Richardson JD, Murrow BA, Holman GD
J Biol Chem. 2011
PubMed ID: 21454690
Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1.
Cheng R, Qiu J, Zhou XY, Chen XH, Zhu C, Qin DN, Wang JW, Ni YH, Ji CB, Guo XR
Mol Med Report. 2011
PubMed ID: 21468601
Exercise-stimulated GLUT4 expression is similar in normotensive and hypertensive rats.
Lehnen AM, Leguisamo NM, Pinto GH, Markoski M, De Angelis K, Machado UF, Schaan B
Horm Metab Res. 2011
PubMed ID: 21332027
GLUT4 in murine bone growth: from uptake and translocation to proliferation and differentiation.
Maor G, Vasiliver-Shamis G, Hazan-Brill R, Wertheimer E, Karnieli E
Am J Physiol Endocrinol Metab. 2011
PubMed ID: 20923959
Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells.
Yee KK, Sukumaran SK, Kotha R, Gilbertson TA, Margolskee RF
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21383163
Kinetic evidence that Glut4 follows different endocytic pathways than the receptors for transferrin and alpha2-macroglobulin.
Habtemichael EN, Brewer PD, Romenskaia I, Mastick CC
J Biol Chem. 2011
PubMed ID: 21252237
Prenylated chalcones 4-hydroxyderricin and xanthoangelol stimulate glucose uptake in skeletal muscle cells by inducing GLUT4 translocation.
Kawabata K, Sawada K, Ikeda K, Fukuda I, Kawasaki K, Yamamoto N, Ashida H
Mol Nutr Food Res. 2011
PubMed ID: 20938990
Vimentin binds IRAP and is involved in GLUT4 vesicle trafficking.
Hirata Y, Hosaka T, Iwata T, Le CT, Jambaldorj B, Teshigawara K, Harada N, Sakaue H, Sakai T, Yoshimoto K, Nakaya Y
Biochem Biophys Res Commun. 2011
PubMed ID: 21216232
Human cytomegalovirus activates glucose transporter 4 expression to increase glucose uptake during infection.
Yu Y, Maguire TG, Alwine JC
J Virol. 2011
PubMed ID: 21147915
Neuromuscular electrical stimulation improves GLUT-4 and morphological characteristics of skeletal muscle in rats with heart failure.
de Leon EB, Bortoluzzi A, Rucatti A, Nunes RB, Saur L, Rodrigues M, Oliveira U, Alves-Wagner AB, Xavier LL, Machado UF, Schaan BD, Dall'Ago P
Acta Physiol (Oxf). 2011
PubMed ID: 20698833
Class II histone deacetylases limit GLUT4 gene expression during adipocyte differentiation.
Weems J, Olson AL
J Biol Chem. 2011
PubMed ID: 21047791
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Enhanced energy expenditure, glucose utilization, and insulin sensitivity in VAMP8 null mice.
Zong H, Wang CC, Vaitheesvaran B, Kurland IJ, Hong W, Pessin JE
Diabetes. 2011
PubMed ID: 20876717
PKCε regulates contraction-stimulated GLUT4 traffic in skeletal muscle cells.
Niu W, Bilan PJ, Yu J, Gao J, Boguslavsky S, Schertzer JD, Chu G, Yao Z, Klip A
J Cell Physiol. 2011
PubMed ID: 20658540
Trans-10, cis-12 conjugated linoleic acid inhibits skeletal muscle differentiation and GLUT4 expression independently from NF-κB activation.
Hommelberg PP, Plat J, Remels AH, van Essen AL, Kelders MC, Mensink RP, Schols AM, Langen RC
Mol Nutr Food Res. 2010
PubMed ID: 20568237
Translocation of the Na+/H+ exchanger 1 (NHE1) in cardiomyocyte responses to insulin and energy-status signalling.
Lawrence SP, Holman GD, Koumanov F
Biochem J. 2010
PubMed ID: 20868366
Effects of the HIV protease inhibitor ritonavir on GLUT4 knock-out mice.
Vyas AK, Koster JC, Tzekov A, Hruz PW
J Biol Chem. 2010
PubMed ID: 20864532
Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells.
Sun Y, Bilan PJ, Liu Z, Klip A
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21041651
Palmitate-induced down-regulation of sortilin and impaired GLUT4 trafficking in C2C12 myotubes.
Tsuchiya Y, Hatakeyama H, Emoto N, Wagatsuma F, Matsushita S, Kanzaki M
J Biol Chem. 2010
PubMed ID: 20805226
Insulin-regulated trafficking of GLUT4 requires ubiquitination.
Lamb CA, McCann RK, Stöckli J, James DE, Bryant NJ
Traffic. 2010
PubMed ID: 20854370
Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).
Campa D, Hüsing A, Chang-Claude J, Dostal L, Boeing H, Kröger J, Tjønneland A, Roswall N, Overvad K, Dahm CC, Rodríguez L, Sala N, Pérez MJ, Larrañaga N, Chirlaque MD, Ardanaz E, Khaw KT, Wareham N, Allen NE, Travis RC, Trichopoulou A, Naska A, Bamia C, Palli D, Sieri S, Tumino R, Sacerdote C, van Kranen HJ, Bas Bueno-de-Mesquita H, Stattin P, Johansson M, Chajes V, Rinaldi S, Romieu I, Siddiq A, Norat T, Riboli E, Kaaks R, Canzian F
Eur J Cancer. 2010
PubMed ID: 20965718
Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells.
Chiu TT, Patel N, Shaw AE, Bamburg JR, Klip A
Mol Biol Cell. 2010
PubMed ID: 20739464
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Requirement for distinct vesicle-associated membrane proteins in insulin- and AMP-activated protein kinase (AMPK)-induced translocation of GLUT4 and CD36 in cultured cardiomyocytes.
Schwenk RW, Dirkx E, Coumans WA, Bonen A, Klip A, Glatz JF, Luiken JJ
Diabetologia. 2010
PubMed ID: 20582536
Insulin controls the spatial distribution of GLUT4 on the cell surface through regulation of its postfusion dispersal.
Stenkula KG, Lizunov VA, Cushman SW, Zimmerberg J
Cell Metab. 2010
PubMed ID: 20816091
A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes.
Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J, Nicoloro S, Chawla A, Czech MP
J Biol Chem. 2010
PubMed ID: 20587420
Kinetics of contraction-induced GLUT4 translocation in skeletal muscle fibers from living mice.
Lauritzen HP, Galbo H, Toyoda T, Goodyear LJ
Diabetes. 2010
PubMed ID: 20622170
Identification of glucose transporter 4 knockdown-dependent transcriptional activation element on the retinol binding protein 4 gene promoter and requirement of the 20 S proteasome subunit for transcriptional activity.
Inoue E, Yamashita A, Inoue H, Sekiguchi M, Shiratori A, Yamamoto Y, Tadokoro T, Ishimi Y, Yamauchi J
J Biol Chem. 2010
PubMed ID: 20530491
Identification of three distinct functional sites of insulin-mediated GLUT4 trafficking in adipocytes using quantitative single molecule imaging.
Fujita H, Hatakeyama H, Watanabe TM, Sato M, Higuchi H, Kanzaki M
Mol Biol Cell. 2010
PubMed ID: 20519436
Measuring GLUT4 translocation in mature muscle fibers.
Lauritzen HP, Schertzer JD
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 20501875
Biogenesis and regulation of insulin-responsive vesicles containing GLUT4.
Bogan JS, Kandror KV
Curr Opin Cell Biol. 2010
PubMed ID: 20417083
Role of the transcriptional factors FOXO1 and PPARG on gene expression of SLC2A4 in endometrial tissue from women with polycystic ovary syndrome.
Kohan K, Carvajal R, Gabler F, Vantman D, Romero C, Vega M
Reproduction. 2010
PubMed ID: 20406953
Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma.
Ueda S, Kitazawa S, Ishida K, Nishikawa Y, Matsui M, Matsumoto H, Aoki T, Nozaki S, Takeda T, Tamori Y, Aiba A, Kahn CR, Kataoka T, Satoh T
FASEB J. 2010
PubMed ID: 20203090
Insulin-regulated aminopeptidase is a key regulator of GLUT4 trafficking by controlling the sorting of GLUT4 from endosomes to specialized insulin-regulated vesicles.
Jordens I, Molle D, Xiong W, Keller SR, McGraw TE
Mol Biol Cell. 2010
PubMed ID: 20410133
SPARC interacts with AMPK and regulates GLUT4 expression.
Song H, Guan Y, Zhang L, Li K, Dong C
Biochem Biophys Res Commun. 2010
PubMed ID: 20460104
[Effects of exercise on expression and phosphorylation of PI3K and PKB in insulin signaling in the skeletal muscles of type 2 diabetic rats].
Cao SC, Zhao G, Chang B, Zhang H
Nan Fang Yi Ke Da Xue Xue Bao. 2010
PubMed ID: 20584641
MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism.
Lu H, Buchan RJ, Cook SA
Cardiovasc Res. 2010
PubMed ID: 20080987
Regulation of cardiomyocyte Glut4 expression by ZAC1.
Czubryt MP, Lamoureux L, Ramjiawan A, Abrenica B, Jangamreddy J, Swan K
J Biol Chem. 2010
PubMed ID: 20363751
Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection.
Tsutsumi YM, Kawaraguchi Y, Horikawa YT, Niesman IR, Kidd MW, Chin-Lee B, Head BP, Patel PM, Roth DM, Patel HH
Anesthesiology. 2010
PubMed ID: 20418694
Effects of testosterone and metformin on glucose metabolism in endometrium.
Zhang L, Liao Q
Fertil Steril. 2010
PubMed ID: 19328476
Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury.
Hyvärinen J, Hassinen IE, Sormunen R, Mäki JM, Kivirikko KI, Koivunen P, Myllyharju J
J Biol Chem. 2010
PubMed ID: 20185832
Altered GLUT4 trafficking in adipocytes in the absence of the GTPase Arfrp1.
Hesse D, Hommel A, Jaschke A, Moser M, Bernhardt U, Zahn C, Kluge R, Wittschen P, Gruber AD, Al-Hasani H, Joost HG, Schürmann A
Biochem Biophys Res Commun. 2010
PubMed ID: 20230794
Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels.
Herman MA, She P, Peroni OD, Lynch CJ, Kahn BB
J Biol Chem. 2010
PubMed ID: 20093359
GLUT4 is sorted to vesicles whose accumulation beneath and insertion into the plasma membrane are differentially regulated by insulin and selectively affected by insulin resistance.
Xiong W, Jordens I, Gonzalez E, McGraw TE
Mol Biol Cell. 2010
PubMed ID: 20181829
Acute inhibition of fatty acid import inhibits GLUT4 transcription in adipose tissue, but not skeletal or cardiac muscle tissue, partly through liver X receptor (LXR) signaling.
Griesel BA, Weems J, Russell RA, Abel ED, Humphries K, Olson AL
Diabetes. 2010
PubMed ID: 20103707
Targeted GLUT-4 deficiency in the heart induces cardiomyocyte hypertrophy and impaired contractility linked with Ca(2+) and proton flux dysregulation.
Domenighetti AA, Danes VR, Curl CL, Favaloro JM, Proietto J, Delbridge LM
J Mol Cell Cardiol. 2010
PubMed ID: 19962383
Diabetes and obesity during pregnancy alter insulin signalling and glucose transporter expression in maternal skeletal muscle and subcutaneous adipose tissue.
Colomiere M, Permezel M, Lappas M
J Mol Endocrinol. 2010
PubMed ID: 19955252
Alterations in adipocyte glucose transporter GLUT4 and circulating adiponectin and visfatin in rat adjuvant induced arthritis.
Jurcovicová J, Stofková A, Skurlová M, Baculíková M, Zórad S, Stancíková M
Gen Physiol Biophys. 2010
PubMed ID: 20371884
Long-term ethanol exposure inhibits glucose transporter 4 expression via an AMPK-dependent pathway in adipocytes.
Feng L, Song YF, Guan QB, Liu HJ, Ban B, Dong HX, Hou XL, Lee KO, Gao L, Zhao JJ
Acta Pharmacol Sin. 2010
PubMed ID: 20173759
Effects of nonexhaustive bouts of high-intensity intermittent swimming training on GLUT-4 expression in rat skeletal muscle.
Fujimoto E, Machida S, Higuchi M, Tabata I
J Physiol Sci. 2010
PubMed ID: 20024634
Reduced glucose transporter GLUT4 in skeletal muscle predicts insulin resistance in non-diabetic chronic heart failure patients independently of body composition.
Doehner W, Gathercole D, Cicoira M, Krack A, Coats AJ, Camici PG, Anker SD
Int J Cardiol. 2010
PubMed ID: 18778861
A serum factor induces insulin-independent translocation of GLUT4 to the cell surface which is maintained in insulin resistance.
Berenguer M, Martinez L, Giorgetti-Peraldi S, Le Marchand-Brustel Y, Govers R
PLoS One. 2010
PubMed ID: 21187969
The beneficial effects of exercise in rodents are preserved after detraining: a phenomenon unrelated to GLUT4 expression.
Lehnen AM, Leguisamo NM, Pinto GH, Markoski MM, De Angelis K, Machado UF, Schaan B
Cardiovasc Diabetol. 2010
PubMed ID: 21029425
Case-control analysis of SNPs in GLUT4, RBP4 and STRA6: association of SNPs in STRA6 with type 2 diabetes in a South Indian population.
Nair AK, Sugunan D, Kumar H, Anilkumar G
PLoS One. 2010
PubMed ID: 20625434
Angiotensin II inhibits insulin-stimulated GLUT4 translocation and Akt activation through tyrosine nitration-dependent mechanisms.
Csibi A, Communi D, Müller N, Bottari SP
PLoS One. 2010
PubMed ID: 20383279
Diversity in the glucose transporter-4 gene (SLC2A4) in humans reflects the action of natural selection along the old-world primates evolution.
Tarazona-Santos E, Fabbri C, Yeager M, Magalhaes WC, Burdett L, Crenshaw A, Pettener D, Chanock SJ
PLoS One. 2010
PubMed ID: 20352120
Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-L1 adipocytes.
Chung le TK, Hosaka T, Harada N, Jambaldorj B, Fukunaga K, Nishiwaki Y, Teshigawara K, Sakai T, Nakaya Y, Funaki M
Biochem Biophys Res Commun. 2010
PubMed ID: 19968963
Adenosine monophosphate-activated protein kinase activation, substrate transporter translocation, and metabolism in the contracting hyperthyroid rat heart.
Heather LC, Cole MA, Atherton HJ, Coumans WA, Evans RD, Tyler DJ, Glatz JF, Luiken JJ, Clarke K
Endocrinology. 2010
PubMed ID: 19940039
Brain-derived neurotrophic factor treatment increases the skeletal muscle glucose transporter 4 protein expression in mice.
Suwa M, Yamamoto KI, Nakano H, Sasaki H, Radak Z, Kumagai S
Physiol Res. 2010
PubMed ID: 19929144
Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling.
Jedrychowski MP, Gartner CA, Gygi SP, Zhou L, Herz J, Kandror KV, Pilch PF
J Biol Chem. 2010
PubMed ID: 19864425
Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF
Circulation. 2009
PubMed ID: 19948975
A negative regulatory pathway of GLUT4 trafficking in adipocyte: new function of RIP140 in the cytoplasm via AS160.
Ho PC, Lin YW, Tsui YC, Gupta P, Wei LN
Cell Metab. 2009
PubMed ID: 19945409
MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes.
Horie T, Ono K, Nishi H, Iwanaga Y, Nagao K, Kinoshita M, Kuwabara Y, Takanabe R, Hasegawa K, Kita T, Kimura T
Biochem Biophys Res Commun. 2009
PubMed ID: 19720047
Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent.
Grillo CA, Piroli GG, Hendry RM, Reagan LP
Brain Res. 2009
PubMed ID: 19679110
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Cellular glucose transport and glucotransporter 4 expression as a therapeutic target: clinical and experimental studies.
Czech A, Piatkiewicz P, Tatoń J
Arch Immunol Ther Exp (Warsz). 2009
PubMed ID: 19885647
Beta-adrenergic activity preserves GLUT4 protein in glycolytic fibers in fasting.
Alves-Wagner AB, De Freitas HS, De Souza PB, Seraphim PM, Mori RC, Machado UF
Muscle Nerve. 2009
PubMed ID: 19722251
Effects of contraction on localization of GLUT4 and v-SNARE isoforms in rat skeletal muscle.
Rose AJ, Jeppesen J, Kiens B, Richter EA
Am J Physiol Regul Integr Comp Physiol. 2009
PubMed ID: 19675279
Sex steroids deficiency impairs glucose transporter 4 expression and its translocation through defective Akt phosphorylation in target tissues of adult male rat.
Muthusamy T, Murugesan P, Balasubramanian K
Metabolism. 2009
PubMed ID: 19615701
Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation.
Peck GR, Chavez JA, Roach WG, Budnik BA, Lane WS, Karlsson HK, Zierath JR, Lienhard GE
J Biol Chem. 2009
PubMed ID: 19740738
The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume.
Blanc L, Liu J, Vidal M, Chasis JA, An X, Mohandas N
Blood. 2009
PubMed ID: 19724054
Developmentally spliced PKCbetaII provides a possible link between mTORC2 and Akt kinase to regulate 3T3-L1 adipocyte insulin-stimulated glucose transport.
Kleiman E, Carter G, Ghansah T, Patel NA, Cooper DR
Biochem Biophys Res Commun. 2009
PubMed ID: 19686698
Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes.
Zhao P, Yang L, Lopez JA, Fan J, Burchfield JG, Bai L, Hong W, Xu T, James DE
J Cell Sci. 2009
PubMed ID: 19759285
Nuclear factor-kappaB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis.
Matsuda N, Yamamoto S, Yokoo H, Tobe K, Hattori Y
Crit Care Med. 2009
PubMed ID: 19707125
Degradation of IRS1 leads to impaired glucose uptake in adipose tissue of the type 2 diabetes mouse model TALLYHO/Jng.
Wang Y, Nishina PM, Naggert JK
J Endocrinol. 2009
PubMed ID: 19587264
The molecular basis of insulin-stimulated glucose uptake: signalling, trafficking and potential drug targets.
Leney SE, Tavaré JM
J Endocrinol. 2009
PubMed ID: 19389739
Targeting glucose consumption and autophagy in myeloma with the novel nucleoside analogue 8-aminoadenosine.
Shanmugam M, McBrayer SK, Qian J, Raikoff K, Avram MJ, Singhal S, Gandhi V, Schumacker PT, Krett NL, Rosen ST
J Biol Chem. 2009
PubMed ID: 19648108
Identification of a distal GLUT4 trafficking event controlled by actin polymerization.
Lopez JA, Burchfield JG, Blair DH, Mele K, Ng Y, Vallotton P, James DE, Hughes WE
Mol Biol Cell. 2009
PubMed ID: 19605560
A dual role of the N-terminal FQQI motif in GLUT4 trafficking.
Bernhardt U, Carlotti F, Hoeben RC, Joost HG, Al-Hasani H
Biol Chem. 2009
PubMed ID: 19558319
Insulin-stimulated translocation of glucose transporter (GLUT) 12 parallels that of GLUT4 in normal muscle.
Stuart CA, Howell ME, Zhang Y, Yin D
J Clin Endocrinol Metab. 2009
PubMed ID: 19549745
Regulation of glucose uptake in mesangial cells stimulated by high glucose: role of angiotensin II and insulin.
Arnoni CP, Lima C, Cristovam PC, Maquigussa E, Vidotti DB, Boim MA
Exp Biol Med (Maywood). 2009
PubMed ID: 19546347
RUVBL2, a novel AS160-binding protein, regulates insulin-stimulated GLUT4 translocation.
Xie X, Chen Y, Xue P, Fan Y, Deng Y, Peng G, Yang F, Xu T
Cell Res. 2009
PubMed ID: 19532121
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma.
Fonteyne P, Casneuf V, Pauwels P, Van Damme N, Peeters M, Dierckx R, Van de Wiele C
Histol Histopathol. 2009
PubMed ID: 19554504
Caveolin-1 loss of function accelerates glucose transporter 4 and insulin receptor degradation in 3T3-L1 adipocytes.
González-Muñoz E, López-Iglesias C, Calvo M, Palacín M, Zorzano A, Camps M
Endocrinology. 2009
PubMed ID: 19406948
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
The F-BAR protein CIP4 promotes GLUT4 endocytosis through bidirectional interactions with N-WASp and Dynamin-2.
Hartig SM, Ishikura S, Hicklen RS, Feng Y, Blanchard EG, Voelker KA, Pichot CS, Grange RW, Raphael RM, Klip A, Corey SJ
J Cell Sci. 2009
PubMed ID: 19509061
Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation.
Jørgensen SB, Honeyman J, Oakhill JS, Fazakerley D, Stöckli J, Kemp BE, Steinberg GR
Am J Physiol Endocrinol Metab. 2009
PubMed ID: 19435854
The Cdk5 inhibitor roscovitine strongly inhibits glucose uptake in 3T3-L1 adipocytes without altering GLUT4 translocation from internal pools to the cell surface.
Muruáis G, Lalioti V, Sandoval IV
J Cell Physiol. 2009
PubMed ID: 19326393
Regulation of GLUT4 expression in denervated skeletal muscle.
Jensen EB, Zheng D, Russell RA, Bassel-Duby R, Williams RS, Olson AL, Dohm GL
Am J Physiol Regul Integr Comp Physiol. 2009
PubMed ID: 19321702
Up-regulating the hemeoxygenase system enhances insulin sensitivity and improves glucose metabolism in insulin-resistant diabetes in Goto-Kakizaki rats.
Ndisang JF, Jadhav A
Endocrinology. 2009
PubMed ID: 19228889
A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.
Vassilopoulos S, Esk C, Hoshino S, Funke BH, Chen CY, Plocik AM, Wright WE, Kucherlapati R, Brodsky FM
Science. 2009
PubMed ID: 19478182
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Glucose transporter 4 and insulin receptor substrate-1 messenger RNA expression in omental and subcutaneous adipose tissue in women.
Veilleux A, Blouin K, Rhéaume C, Daris M, Marette A, Tchernof A
Metabolism. 2009
PubMed ID: 19375584
Glucose Tranporter-4 expression in monocytes: a systematic review.
Mavros Y, Simar D, Singh MA
Diabetes Res Clin Pract. 2009
PubMed ID: 19286271
Permissive action of protein kinase C-zeta in insulin-induced CD36- and GLUT4 translocation in cardiac myocytes.
Luiken JJ, Ouwens DM, Habets DD, van der Zon GC, Coumans WA, Schwenk RW, Bonen A, Glatz JF
J Endocrinol. 2009
PubMed ID: 19273501
Caveolin, GLUT4 and insulin receptor protein content in human arm and leg muscles.
Kim HS, Kim HJ, Kim YS, Park SC, Harris R, Kim CK
Eur J Appl Physiol. 2009
PubMed ID: 19219452
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues.
Bakirtzi K, Belfort G, Lopez-Coviella I, Kuruppu D, Cao L, Abel ED, Brownell AL, Kandror KV
J Neurosci. 2009
PubMed ID: 19386915
GAPDH binds GLUT4 reciprocally to hexokinase-II and regulates glucose transport activity.
Zaid H, Talior-Volodarsky I, Antonescu C, Liu Z, Klip A
Biochem J. 2009
PubMed ID: 19140804
Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
Wollscheid B, Bausch-Fluck D, Henderson C, O'Brien R, Bibel M, Schiess R, Aebersold R, Watts JD
Nat Biotechnol. 2009
PubMed ID: 19349973
Kinetics of GLUT4 trafficking in rat and human skeletal muscle.
Karlsson HK, Chibalin AV, Koistinen HA, Yang J, Koumanov F, Wallberg-Henriksson H, Zierath JR, Holman GD
Diabetes. 2009
PubMed ID: 19188436
Insulin resistance and altered glucose transporter 4 expression in experimental uremia.
Aksentijević D, Bhandari S, Seymour AM
Kidney Int. 2009
PubMed ID: 19177156
The C-terminus of GLUT4 targets the transporter to the perinuclear compartment but not to the insulin-responsive vesicles.
Li LV, Bakirtzi K, Watson RT, Pessin JE, Kandror KV
Biochem J. 2009
PubMed ID: 19076072
A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle.
Schertzer JD, Antonescu CN, Bilan PJ, Jain S, Huang X, Liu Z, Bonen A, Klip A
Endocrinology. 2009
PubMed ID: 19074577
Insulin regulates fusion of GLUT4 vesicles independent of Exo70-mediated tethering.
Lizunov VA, Lisinski I, Stenkula K, Zimmerberg J, Cushman SW
J Biol Chem. 2009
PubMed ID: 19155211
The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes.
Lalioti V, Muruais G, Dinarina A, van Damme J, Vandekerckhove J, Sandoval IV
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19255425
Growth hormone inhibition of glucose uptake in adipocytes occurs without affecting GLUT4 translocation through an insulin receptor substrate-2-phosphatidylinositol 3-kinase-dependent pathway.
Sasaki-Suzuki N, Arai K, Ogata T, Kasahara K, Sakoda H, Chida K, Asano T, Pessin JE, Hakuno F, Takahashi S
J Biol Chem. 2009
PubMed ID: 19122000
A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling.
Fazakerley DJ, Lawrence SP, Lizunov VA, Cushman SW, Holman GD
J Cell Sci. 2009
PubMed ID: 19208760
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.
Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky JM
Mol Cell Biol. 2009
PubMed ID: 19103747
Development of a novel GLUT4 translocation assay for identifying potential novel therapeutic targets for insulin sensitization.
Liu F, Dallas-Yang Q, Castriota G, Fischer P, Santini F, Ferrer M, Li J, Akiyama TE, Berger JP, Zhang BB, Jiang G
Biochem J. 2009
PubMed ID: 19035854
[Research of the relationship between insulin signal transduction and glucose transportation in rats after trauma]
Jiang Y, Wu GH
Zhonghua Wai Ke Za Zhi. 2009
PubMed ID: 19563078
DOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytes.
Fukuda N, Emoto M, Nakamori Y, Taguchi A, Miyamoto S, Uraki S, Oka Y, Tanizawa Y
Diabetes. 2009
PubMed ID: 19033398
Daxx functions as a scaffold of a protein assembly constituted by GLUT4, JNK1 and KIF5B.
Lalioti VS, Vergarajauregui S, Tsuchiya Y, Hernandez-Tiedra S, Sandoval IV
J Cell Physiol. 2009
PubMed ID: 18932217
Chronic-intermittent cold stress in rats induces selective ovarian insulin resistance.
Dorfman M, Ramirez VD, Stener-Victorin E, Lara HE
Biol Reprod. 2009
PubMed ID: 18923160
Impairment of insulin-stimulated Akt/GLUT4 signaling is associated with cardiac contractile dysfunction and aggravates I/R injury in STZ-diabetic rats.
Huang JP, Huang SS, Deng JY, Hung LM
J Biomed Sci. 2009
PubMed ID: 19706162
Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte.
Kaddai V, Gonzalez T, Keslair F, Grémeaux T, Bonnafous S, Gugenheim J, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M
PLoS One. 2009
PubMed ID: 19590752
Intracellular retention and insulin-stimulated mobilization of GLUT4 glucose transporters.
Rubin BR, Bogan JS
Vitam Horm. 2009
PubMed ID: 19251038
Chronic elevated calcium blocks AMPK-induced GLUT-4 expression in skeletal muscle.
Park S, Scheffler TL, Gunawan AM, Shi H, Zeng C, Hannon KM, Grant AL, Gerrard DE
Am J Physiol Cell Physiol. 2009
PubMed ID: 18971392
Effects of glucose deprivation or glucose instability on mesangial cells in culture.
de Lima E Santos C, Arnoni CP, Schor N, Boim MA
Am J Nephrol. 2009
PubMed ID: 18797165
CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation.
Okada S, Yamada E, Saito T, Ohshima K, Hashimoto K, Yamada M, Uehara Y, Tsuchiya T, Shimizu H, Tatei K, Izumi T, Yamauchi K, Hisanaga S, Pessin JE, Mori M
J Biol Chem. 2008
PubMed ID: 18948252
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
Upregulation of GLUT-4 in right ventricle of rats with monocrotaline-induced pulmonary hypertension.
Broderick TL, King TM
Med Sci Monit. 2008
PubMed ID: 19043358
Regulation of glucose transporter 4 translocation by the Rab guanosine triphosphatase-activating protein AS160/TBC1D4: role of phosphorylation and membrane association.
Stöckli J, Davey JR, Hohnen-Behrens C, Xu A, James DE, Ramm G
Mol Endocrinol. 2008
PubMed ID: 18801932
The Glut1 and Glut4 glucose transporters are differentially expressed during perinatal and postnatal erythropoiesis.
Montel-Hagen A, Blanc L, Boyer-Clavel M, Jacquet C, Vidal M, Sitbon M, Taylor N
Blood. 2008
PubMed ID: 18796630
Lipocalin-type prostaglandin D(2) synthase stimulates glucose transport via enhanced GLUT4 translocation.
Ragolia L, Hall CE, Palaia T
Prostaglandins Other Lipid Mediat. 2008
PubMed ID: 18619553
Insulin resistance of pregnancy involves estrogen-induced repression of muscle GLUT4.
Barros RP, Morani A, Moriscot A, Machado UF
Mol Cell Endocrinol. 2008
PubMed ID: 18692545
Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells.
Shi X, Burkart A, Nicoloro SM, Czech MP, Straubhaar J, Corvera S
J Biol Chem. 2008
PubMed ID: 18779333
CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes.
Yip MF, Ramm G, Larance M, Hoehn KL, Wagner MC, Guilhaus M, James DE
Cell Metab. 2008
PubMed ID: 19046570
Contractile C2C12 myotube model for studying exercise-inducible responses in skeletal muscle.
Nedachi T, Fujita H, Kanzaki M
Am J Physiol Endocrinol Metab. 2008
PubMed ID: 18780777
Self-assembly of Glut4 storage vesicles during differentiation of 3T3-L1 adipocytes.
Shi J, Huang G, Kandror KV
J Biol Chem. 2008
PubMed ID: 18713752
Murine CENPF interacts with syntaxin 4 in the regulation of vesicular transport.
Pooley RD, Moynihan KL, Soukoulis V, Reddy S, Francis R, Lo C, Ma LJ, Bader DM
J Cell Sci. 2008
PubMed ID: 18827011
Dual role for myosin II in GLUT4-mediated glucose uptake in 3T3-L1 adipocytes.
Fulcher FK, Smith BT, Russ M, Patel YM
Exp Cell Res. 2008
PubMed ID: 18773891
GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells.
Randhawa VK, Ishikura S, Talior-Volodarsky I, Cheng AW, Patel N, Hartwig JH, Klip A
J Biol Chem. 2008
PubMed ID: 18650435
Chromium (D-phenylalanine)3 supplementation alters glucose disposal, insulin signaling, and glucose transporter-4 membrane translocation in insulin-resistant mice.
Dong F, Kandadi MR, Ren J, Sreejayan N
J Nutr. 2008
PubMed ID: 18806091
Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation.
Ishikura S, Klip A
Am J Physiol Cell Physiol. 2008
PubMed ID: 18701652
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
Treadmill exercise training fails to reverse defects in glucose, insulin and muscle GLUT4 content in the db/db mouse model of diabetes.
Sennott J, Morrissey J, Standley PR, Broderick TL
Pathophysiology. 2008
PubMed ID: 18653321
Alpha-actinin-4 is selectively required for insulin-induced GLUT4 translocation.
Talior-Volodarsky I, Randhawa VK, Zaid H, Klip A
J Biol Chem. 2008
PubMed ID: 18617516
Decreasing intramuscular phosphagen content simultaneously increases plasma membrane FAT/CD36 and GLUT4 transporter abundance.
Pandke KE, Mullen KL, Snook LA, Bonen A, Dyck DJ
Am J Physiol Regul Integr Comp Physiol. 2008
PubMed ID: 18650314
CaMK activation during exercise is required for histone hyperacetylation and MEF2A binding at the MEF2 site on the Glut4 gene.
Smith JA, Kohn TA, Chetty AK, Ojuka EO
Am J Physiol Endocrinol Metab. 2008
PubMed ID: 18647882
Altered metabolic and transporter characteristics of vastus lateralis in chronic obstructive pulmonary disease.
Green HJ, Burnett ME, D'Arsigny CL, O'Donnell DE, Ouyang J, Webb KA
J Appl Physiol. 2008
PubMed ID: 18635880
The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus--potential role in modulation of glucose uptake in neurones?
Fernando RN, Albiston AL, Chai SY
Eur J Neurosci. 2008
PubMed ID: 18702730
The CB1 endocannabinoid system modulates adipocyte insulin sensitivity.
Motaghedi R, McGraw TE
Obesity (Silver Spring). 2008
PubMed ID: 18551116
Molecular mechanisms controlling GLUT4 intracellular retention.
Blot V, McGraw TE
Mol Biol Cell. 2008
PubMed ID: 18550797
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
Insulin action on glucose transporters through molecular switches, tracks and tethers.
Zaid H, Antonescu CN, Randhawa VK, Klip A
Biochem J. 2008
PubMed ID: 18570632
Wdnm1-like, a new adipokine with a role in MMP-2 activation.
Wu Y, Smas CM
Am J Physiol Endocrinol Metab. 2008
PubMed ID: 18492766
Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: regulation by mitochondrial uncoupling.
Antonescu CN, Díaz M, Femia G, Planas JV, Klip A
Traffic. 2008
PubMed ID: 18435821
Phosphorylation of CCAAT/enhancer-binding protein alpha regulates GLUT4 expression and glucose transport in adipocytes.
Cha HC, Oak NR, Kang S, Tran TA, Kobayashi S, Chiang SH, Tenen DG, MacDougald OA
J Biol Chem. 2008
PubMed ID: 18408001
Oxidative stress induces GLUT4 translocation by activation of PI3-K/Akt and dual AMPK kinase in cardiac myocytes.
Horie T, Ono K, Nagao K, Nishi H, Kinoshita M, Kawamura T, Wada H, Shimatsu A, Kita T, Hasegawa K
J Cell Physiol. 2008
PubMed ID: 18163380
Identification of Glypican3 as a novel GLUT4-binding protein.
Taguchi A, Emoto M, Okuya S, Fukuda N, Nakamori Y, Miyazaki M, Miyamoto S, Tanabe K, Aburatani H, Oka Y, Tanizawa Y
Biochem Biophys Res Commun. 2008
PubMed ID: 18343214
Histone code modifications repress glucose transporter 4 expression in the intrauterine growth-restricted offspring.
Raychaudhuri N, Raychaudhuri S, Thamotharan M, Devaskar SU
J Biol Chem. 2008
PubMed ID: 18326493
Identification of amino acid residues within the C terminus of the Glut4 glucose transporter that are essential for insulin-stimulated redistribution to the plasma membrane.
Song XM, Hresko RC, Mueckler M
J Biol Chem. 2008
PubMed ID: 18305115
Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation.
Chavez JA, Roach WG, Keller SR, Lane WS, Lienhard GE
J Biol Chem. 2008
PubMed ID: 18258599
Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes.
Ng Y, Ramm G, Lopez JA, James DE
Cell Metab. 2008
PubMed ID: 18396141
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5.
McGee SL, van Denderen BJ, Howlett KF, Mollica J, Schertzer JD, Kemp BE, Hargreaves M
Diabetes. 2008
PubMed ID: 18184930
The proinflammatory cytokine tumor necrosis factor-alpha increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6.
Roher N, Samokhvalov V, Díaz M, MacKenzie S, Klip A, Planas JV
Endocrinology. 2008
PubMed ID: 18162526
Rab10 in insulin-stimulated GLUT4 translocation.
Sano H, Roach WG, Peck GR, Fukuda M, Lienhard GE
Biochem J. 2008
PubMed ID: 18076383
Increased PFK activity and GLUT4 protein content in McArdle's disease.
Robertshaw HA, Raha S, Kaczor JJ, Tarnopolsky MA
Muscle Nerve. 2008
PubMed ID: 18067156
Direct quantification of fusion rate reveals a distal role for AS160 in insulin-stimulated fusion of GLUT4 storage vesicles.
Jiang L, Fan J, Bai L, Wang Y, Chen Y, Yang L, Chen L, Xu T
J Biol Chem. 2008
PubMed ID: 18063571
GLUT4 enhancer factor (GEF) interacts with MEF2A and HDAC5 to regulate the GLUT4 promoter in adipocytes.
Sparling DP, Griesel BA, Weems J, Olson AL
J Biol Chem. 2008
PubMed ID: 18216015
IGF-I increases the recruitment of GLUT4 and GLUT3 glucose transporters on cell surface in hyperthyroidism.
Dimitriadis G, Maratou E, Boutati E, Kollias A, Tsegka K, Alevizaki M, Peppa M, Raptis SA, Hadjidakis DJ
Eur J Endocrinol. 2008
PubMed ID: 18299470
Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK.
Luiken JJ, Vertommen D, Coort SL, Habets DD, El Hasnaoui M, Pelsers MM, Viollet B, Bonen A, Hue L, Rider MH, Glatz JF
Cell Signal. 2008
PubMed ID: 18164589
Polymorphism in postinsulin receptor signaling pathway is not associated with polycystic ovary syndrome.
Jones MR, Wilson SG, Mullin BH, Mead R, Dudbridge F, Watts GF, Stuckey BG
Fertil Steril. 2008
PubMed ID: 18249389
Functional and metabolic remodelling in GLUT4-deficient hearts confers hyper-responsiveness to substrate intervention.
Huggins CE, Domenighetti AA, Ritchie ME, Khalil N, Favaloro JM, Proietto J, Smyth GK, Pepe S, Delbridge LM
J Mol Cell Cardiol. 2008
PubMed ID: 18191142
Effects of caudal fourth ventricular lactate infusion on hypoglycemia-associated MCT2, GLUT3, GLUT4, GCK, and sulfonylurea receptor-1 gene expression in the ovariectomized female rat LHA and VMH: impact of estradiol.
Vavaiya KV, Briski KP
J Mol Neurosci. 2008
PubMed ID: 18084728
Rapid upregulation of GLUT-4 and MCT-4 expression during 16 h of heavy intermittent cycle exercise.
Green HJ, Duhamel TA, Holloway GP, Moule JW, Ranney DW, Tupling AR, Ouyang J
Am J Physiol Regul Integr Comp Physiol. 2008
PubMed ID: 18056982
Large GLUT4 vesicles are stationary while locally and reversibly depleted during transient insulin stimulation of skeletal muscle of living mice: imaging analysis of GLUT4-enhanced green fluorescent protein vesicle dynamics.
Lauritzen HP, Galbo H, Brandauer J, Goodyear LJ, Ploug T
Diabetes. 2008
PubMed ID: 17977960
The GLUT4 code.
Larance M, Ramm G, James DE
Mol Endocrinol. 2008
PubMed ID: 17717074
Mapping of R-SNARE function at distinct intracellular GLUT4 trafficking steps in adipocytes.
Williams D, Pessin JE
J Cell Biol. 2008
PubMed ID: 18227281
Snapin interacts with the Exo70 subunit of the exocyst and modulates GLUT4 trafficking.
Bao Y, Lopez JA, James DE, Hunziker W
J Biol Chem. 2008
PubMed ID: 17947242
Farnesoid X receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter.
Shen H, Zhang Y, Ding H, Wang X, Chen L, Jiang H, Shen X
Cell Physiol Biochem. 2008
PubMed ID: 18769028
Acute-phase serum amyloid A as a marker of insulin resistance in mice.
Scheja L, Heese B, Zitzer H, Michael MD, Siesky AM, Pospisil H, Beisiegel U, Seedorf K
Exp Diabetes Res. 2008
PubMed ID: 18584041
An intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles.
Heyward CA, Pettitt TR, Leney SE, Welsh GI, Tavaré JM, Wakelam MJ
BMC Cell Biol. 2008
PubMed ID: 18492238
Effects of continuous low-carbohydrate diet after long-term exercise on GLUT-4 protein content in rat skeletal muscle.
Kubota M, Koshinaka K, Kawata Y, Koike T, Oshida Y
Horm Metab Res. 2008
PubMed ID: 18335580
Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4.
van Oort MM, van Doorn JM, Bonen A, Glatz JF, van der Horst DJ, Rodenburg KW, Luiken JJ
Biochim Biophys Acta. 2008
PubMed ID: 18167317
Chemical hypoxia-induced glucose transporter-4 translocation in neonatal rat cardiomyocytes.
Guan F, Yu B, Qi GX, Hu J, Zeng DY, Luo J
Arch Med Res. 2008
PubMed ID: 18067996
Tyrosine phosphorylation of Munc18c regulates platelet-derived growth factor-stimulated glucose transporter 4 translocation in 3T3L1 adipocytes.
Umahara M, Okada S, Yamada E, Saito T, Ohshima K, Hashimoto K, Yamada M, Shimizu H, Pessin JE, Mori M
Endocrinology. 2008
PubMed ID: 17916632
Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart.
Burkart EM, Sambandam N, Han X, Gross RW, Courtois M, Gierasch CM, Shoghi K, Welch MJ, Kelly DP
J Clin Invest. 2007
PubMed ID: 18037994
Rip11 is a Rab11- and AS160-RabGAP-binding protein required for insulin-stimulated glucose uptake in adipocytes.
Welsh GI, Leney SE, Lloyd-Lewis B, Wherlock M, Lindsay AJ, McCaffrey MW, Tavaré JM
J Cell Sci. 2007
PubMed ID: 18003705
The glucose transporter 4 FQQI motif is necessary for Akt substrate of 160-kilodalton-dependent plasma membrane translocation but not Golgi-localized (gamma)-ear-containing Arf-binding protein-dependent entry into the insulin-responsive storage compartmen
Capilla E, Suzuki N, Pessin JE, Hou JC
Mol Endocrinol. 2007
PubMed ID: 17761952
FIP2 and Rip11 specify Rab11a-mediated cellular distribution of GLUT4 and FAT/CD36 in H9c2-hIR cells.
Schwenk RW, Luiken JJ, Eckel J
Biochem Biophys Res Commun. 2007
PubMed ID: 17854769
Hepatic response to restoration of GLUT4 in skeletal muscle of GLUT4 null mice.
Ranalletta M, Du XQ, Seki Y, Glenn AS, Kruse M, Fiallo A, Estrada I, Tsao TS, Stenbit AE, Katz EB, Charron MJ
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17711992
GLUT4 translocation: the last 200 nanometers.
Watson RT, Pessin JE
Cell Signal. 2007
PubMed ID: 17629673
Repression of GLUT4 expression by the endoplasmic reticulum stress response in 3T3-L1 adipocytes.
Miller RS, Diaczok D, Cooke DW
Biochem Biophys Res Commun. 2007
PubMed ID: 17698029
Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle.
Lira VA, Soltow QA, Long JH, Betters JL, Sellman JE, Criswell DS
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17666490
Age related obesity-induced shortening of GLUT4 mRNA poly(A) tail length in rat gastrocnemius skeletal muscle.
Seraphim PM, Nunes MT, Giannocco G, Machado UF
Mol Cell Endocrinol. 2007
PubMed ID: 17709177
[Mechanism of rosiglitasone to improve glucose-uptake of 3T3-L1 adipocyte with insulin resistance induced by dexamethasone and insulin]
Yang GZ, Gao XP, Yan JF, Ou KQ, Zhao J
Sichuan Da Xue Xue Bao Yi Xue Ban. 2007
PubMed ID: 17953366
Glut-4 is translocated to both caveolae and non-caveolar lipid rafts, but is partially internalized through caveolae in insulin-stimulated adipocytes.
Yuan T, Hong S, Yao Y, Liao K
Cell Res. 2007
PubMed ID: 17846641
Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c.
Chen XW, Leto D, Chiang SH, Wang Q, Saltiel AR
Dev Cell. 2007
PubMed ID: 17765682
Two phases of palmitate-induced insulin resistance in skeletal muscle: impaired GLUT4 translocation is followed by a reduced GLUT4 intrinsic activity.
Alkhateeb H, Chabowski A, Glatz JF, Luiken JF, Bonen A
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17550999
Expression of glucose transporters in epithelial ovarian carcinoma: correlation with clinical characteristics and tumor angiogenesis.
Tsukioka M, Matsumoto Y, Noriyuki M, Yoshida C, Nobeyama H, Yoshida H, Yasui T, Sumi T, Honda K, Ishiko O
Oncol Rep. 2007
PubMed ID: 17611657
The SUMO conjugating enzyme Ubc9 is a regulator of GLUT4 turnover and targeting to the insulin-responsive storage compartment in 3T3-L1 adipocytes.
Liu LB, Omata W, Kojima I, Shibata H
Diabetes. 2007
PubMed ID: 17536066
Muscle GLUT4 in cirrhosis.
Holland-Fischer P, Andersen PH, Lund S, Pedersen SB, Vinter-Jensen L, Nielsen MF, Kaal A, Dall R, Schmitz O, Vilstrup H
J Hepatol. 2007
PubMed ID: 17448565
Bi-directional transport of GLUT4 vesicles near the plasma membrane of primary rat adipocytes.
Xu YK, Xu KD, Li JY, Feng LQ, Lang D, Zheng XX
Biochem Biophys Res Commun. 2007
PubMed ID: 17532293
Glucose kinetics and exercise tolerance in mice lacking the GLUT4 glucose transporter.
Fueger PT, Li CY, Ayala JE, Shearer J, Bracy DP, Charron MJ, Rottman JN, Wasserman DH
J Physiol. 2007
PubMed ID: 17495042
Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation.
Yoshizaki T, Imamura T, Babendure JL, Lu JC, Sonoda N, Olefsky JM
Mol Cell Biol. 2007
PubMed ID: 17515613
Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes.
Liao W, Nguyen MT, Yoshizaki T, Favelyukis S, Patsouris D, Imamura T, Verma IM, Olefsky JM
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17389706
Preserved expression of GLUT4 prevents enhanced agonist-induced vascular reactivity and MYPT1 phosphorylation in hypertensive mouse aorta.
Atkins KB, Prezkop A, Park JL, Saha J, Duquaine D, Charron MJ, Olson AL, Brosius FC
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17369465
Antihyperglycemic effect of Cephalotaxus sinensis leaves and GLUT-4 translocation facilitating activity of its flavonoid constituents.
Li W, Dai RJ, Yu YH, Li L, Wu CM, Luan WW, Meng WW, Zhang XS, Deng YL
Biol Pharm Bull. 2007
PubMed ID: 17541165
The antioxidant tempol inhibits cardiac hypertrophy in the insulin-resistant GLUT4-deficient mouse in vivo.
Ritchie RH, Quinn JM, Cao AH, Drummond GR, Kaye DM, Favaloro JM, Proietto J, Delbridge LM
J Mol Cell Cardiol. 2007
PubMed ID: 17490678
Molecular characterization of GDD1/TMEM16E, the gene product responsible for autosomal dominant gnathodiaphyseal dysplasia.
Mizuta K, Tsutsumi S, Inoue H, Sakamoto Y, Miyatake K, Miyawaki K, Noji S, Kamata N, Itakura M
Biochem Biophys Res Commun. 2007
PubMed ID: 17418107
Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4.
Jeyaraj S, Boehmer C, Lang F, Palmada M
Biochem Biophys Res Commun. 2007
PubMed ID: 17382906
Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes.
Huang S, Lifshitz LM, Jones C, Bellve KD, Standley C, Fonseca S, Corvera S, Fogarty KE, Czech MP
Mol Cell Biol. 2007
PubMed ID: 17339344
Redox regulation of ischemic preconditioning is mediated by the differential activation of caveolins and their association with eNOS and GLUT-4.
Koneru S, Penumathsa SV, Thirunavukkarasu M, Samuel SM, Zhan L, Han Z, Maulik G, Das DK, Maulik N
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17277024
Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1.
Roach WG, Chavez JA, Mîinea CP, Lienhard GE
Biochem J. 2007
PubMed ID: 17274760
Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane.
Sano H, Eguez L, Teruel MN, Fukuda M, Chuang TD, Chavez JA, Lienhard GE, McGraw TE
Cell Metab. 2007
PubMed ID: 17403373
Expression of a synapsin IIb site 1 phosphorylation mutant in 3T3-L1 adipocytes inhibits basal intracellular retention of Glut4.
Muretta JM, Romenskaia I, Cassiday PA, Mastick CC
J Cell Sci. 2007
PubMed ID: 17341582
Immunogold labeling study of the distribution of GLUT-1 and GLUT-4 in cardiac tissue following stimulation by insulin or ischemia.
Davey KA, Garlick PB, Warley A, Southworth R
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17189352
Hyperphosphorylation of MEF2A in primary adipocytes correlates with downregulation of human GLUT4 gene promoter activity.
Sparling DP, Griesel BA, Olson AL
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17164432
The luminal Vps10p domain of sortilin plays the predominant role in targeting to insulin-responsive Glut4-containing vesicles.
Shi J, Kandror KV
J Biol Chem. 2007
PubMed ID: 17220298
Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes.
Cao H, Polansky MM, Anderson RA
Arch Biochem Biophys. 2007
PubMed ID: 17316549
GLUT4's itinerary in health & disease.
McCarthy AM, Elmendorf JS
Indian J Med Res. 2007
PubMed ID: 17496362
Insulin-stimulated exocytosis of GLUT4 is enhanced by IRAP and its partner tankyrase.
Yeh TY, Sbodio JI, Tsun ZY, Luo B, Chi NW
Biochem J. 2007
PubMed ID: 17059388
Exercise and CaMK activation both increase the binding of MEF2A to the Glut4 promoter in skeletal muscle in vivo.
Smith JA, Collins M, Grobler LA, Magee CJ, Ojuka EO
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 16985263
Corticosterone impairs insulin-stimulated translocation of GLUT4 in the rat hippocampus.
Piroli GG, Grillo CA, Reznikov LR, Adams S, McEwen BS, Charron MJ, Reagan LP
Neuroendocrinology. 2007
PubMed ID: 17426391
Testicular regulation of neuronal glucose and monocarboxylate transporter gene expression profiles in CNS metabolic sensing sites during acute and recurrent insulin-induced hypoglycemia.
Vavaiya KV, Paranjape SA, Briski KP
J Mol Neurosci. 2007
PubMed ID: 17416968
Melatonin protects against oxidative damage and restores expression of GLUT4 gene in the hyperthyroid rat heart.
Ghosh G, De K, Maity S, Bandyopadhyay D, Bhattacharya S, Reiter RJ, Bandyopadhyay A
J Pineal Res. 2007
PubMed ID: 17198541
Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes.
Lodhi IJ, Chiang SH, Chang L, Vollenweider D, Watson RT, Inoue M, Pessin JE, Saltiel AR
Cell Metab. 2007
PubMed ID: 17189207
Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action.
Bai L, Wang Y, Fan J, Chen Y, Ji W, Qu A, Xu P, James DE, Xu T
Cell Metab. 2007
PubMed ID: 17189206
A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression.
van Harmelen V, Rydén M, Sjölin E, Hoffstedt J
J Lipid Res. 2007
PubMed ID: 17035674
Amino acid transporter ATA2 is stored at the trans-Golgi network and released by insulin stimulus in adipocytes.
Hatanaka T, Hatanaka Y, Tsuchida J, Ganapathy V, Setou M
J Biol Chem. 2006
PubMed ID: 17050538
GLUT4 is internalized by a cholesterol-dependent nystatin-sensitive mechanism inhibited by insulin.
Blot V, McGraw TE
EMBO J. 2006
PubMed ID: 17139247
Golgin-160 is required for the Golgi membrane sorting of the insulin-responsive glucose transporter GLUT4 in adipocytes.
Williams D, Hicks SW, Machamer CE, Pessin JE
Mol Biol Cell. 2006
PubMed ID: 17050738
Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo.
Suwa M, Egashira T, Nakano H, Sasaki H, Kumagai S
J Appl Physiol. 2006
PubMed ID: 16902066
Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2.
Hatanaka T, Hatanaka Y, Setou M
J Biol Chem. 2006
PubMed ID: 17003038
Expression of uncoupling protein 3 and GLUT4 gene in skeletal muscle of preterm newborns: possible control by AMP-activated protein kinase.
Brauner P, Kopecky P, Flachs P, Kuda O, Vorlicek J, Planickova L, Vitkova I, Andreelli F, Foretz M, Viollet B, Kopecky J
Pediatr Res. 2006
PubMed ID: 16966355
Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle.
Stuart CA, Yin D, Howell ME, Dykes RJ, Laffan JJ, Ferrando AA
Am J Physiol Endocrinol Metab. 2006
PubMed ID: 16803853
Loss of cortical actin filaments in insulin-resistant skeletal muscle cells impairs GLUT4 vesicle trafficking and glucose transport.
McCarthy AM, Spisak KO, Brozinick JT, Elmendorf JS
Am J Physiol Cell Physiol. 2006
PubMed ID: 16774991
Retinol-binding protein 4 in human obesity.
Janke J, Engeli S, Boschmann M, Adams F, Böhnke J, Luft FC, Sharma AM, Jordan J
Diabetes. 2006
PubMed ID: 17003346
Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane.
Gonzalez E, McGraw TE
Mol Biol Cell. 2006
PubMed ID: 16914513
Role of insulin-dependent cortical fodrin/spectrin remodeling in glucose transporter 4 translocation in rat adipocytes.
Liu L, Jedrychowski MP, Gygi SP, Pilch PF
Mol Biol Cell. 2006
PubMed ID: 16870704
Regulation of GLUT4 gene expression by SREBP-1c in adipocytes.
Im SS, Kwon SK, Kang SY, Kim TH, Kim HI, Hur MW, Kim KS, Ahn YH
Biochem J. 2006
PubMed ID: 16787385
A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160.
Ramm G, Larance M, Guilhaus M, James DE
J Biol Chem. 2006
PubMed ID: 16880201
Cerebral glucose transporters expression and spatial learning in the K-ATP Kir6.2(-/-) knockout mice.
Choeiri C, Staines WA, Miki T, Seino S, Renaud JM, Teutenberg K, Messier C
Behav Brain Res. 2006
PubMed ID: 16797737
Acute exercise and GLUT4 expression in human skeletal muscle: influence of exercise intensity.
Kraniou GN, Cameron-Smith D, Hargreaves M
J Appl Physiol. 2006
PubMed ID: 16763099
Inhibition of calpain results in impaired contraction-stimulated GLUT4 translocation in skeletal muscle.
Otani K, Polonsky KS, Holloszy JO, Han DH
Am J Physiol Endocrinol Metab. 2006
PubMed ID: 16705056
Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane.
Kong AM, Horan KA, Sriratana A, Bailey CG, Collyer LJ, Nandurkar HH, Shisheva A, Layton MJ, Rasko JE, Rowe T, Mitchell CA
Mol Cell Biol. 2006
PubMed ID: 16880518
Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): implications in glycaemic control.
Nakata M, Nagasaka S, Kusaka I, Matsuoka H, Ishibashi S, Yada T
Diabetologia. 2006
PubMed ID: 16685502
FOXO1 represses peroxisome proliferator-activated receptor-gamma1 and -gamma2 gene promoters in primary adipocytes. A novel paradigm to increase insulin sensitivity.
Armoni M, Harel C, Karni S, Chen H, Bar-Yoseph F, Ver MR, Quon MJ, Karnieli E
J Biol Chem. 2006
PubMed ID: 16670091
Identification and characterization of p49/STRAP as a novel GLUT4-binding protein.
Lisinski I, Matsumoto H, Yver DR, Schürmann A, Cushman SW, Al-Hasani H
Biochem Biophys Res Commun. 2006
PubMed ID: 16647043
Altered GLUT4 translocation in skeletal muscle of 12/15-lipoxygenase knockout mice.
Vahsen S, Rakowski K, Ledwig D, Dietze-Schroeder D, Swifka J, Sasson S, Eckel J
Horm Metab Res. 2006
PubMed ID: 16823721
Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK.
Wijesekara N, Tung A, Thong F, Klip A
Am J Physiol Endocrinol Metab. 2006
PubMed ID: 16418206
Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositol 3-kinase- dependent mechanism.
Benomar Y, Naour N, Aubourg A, Bailleux V, Gertler A, Djiane J, Guerre-Millo M, Taouis M
Endocrinology. 2006
PubMed ID: 16497805
Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes.
Liao W, Nguyen MT, Imamura T, Singer O, Verma IM, Olefsky JM
Endocrinology. 2006
PubMed ID: 16497797
Implication of phosphorylation of the myosin II regulatory light chain in insulin-stimulated GLUT4 translocation in 3T3-F442A adipocytes.
Choi YO, Ryu HJ, Kim HR, Song YS, Kim C, Lee W, Choe H, Leem CH, Jang YJ
Exp Mol Med. 2006
PubMed ID: 16672772
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C
Nature. 2006
PubMed ID: 16625196
Low doses of vanadate and Trigonella synergistically regulate Na+/K + -ATPase activity and GLUT4 translocation in alloxan-diabetic rats.
Siddiqui MR, Moorthy K, Taha A, Hussain ME, Baquer NZ
Mol Cell Biochem. 2006
PubMed ID: 16622606
The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes.
Mari M, Monzo P, Kaddai V, Keslair F, Gonzalez T, Le Marchand-Brustel Y, Cormont M
J Cell Sci. 2006
PubMed ID: 16522682
Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells.
Fecchi K, Volonte D, Hezel MP, Schmeck K, Galbiati F
FASEB J. 2006
PubMed ID: 16455755
alpha2 Isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-d-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal m
Nakano M, Hamada T, Hayashi T, Yonemitsu S, Miyamoto L, Toyoda T, Tanaka S, Masuzaki H, Ebihara K, Ogawa Y, Hosoda K, Inoue G, Yoshimasa Y, Otaka A, Fushiki T, Nakao K
Metabolism. 2006
PubMed ID: 16483872
Passive stretching produces Akt- and MAPK-dependent augmentations of GLUT4 translocation and glucose uptake in skeletal muscles of mice.
Ito Y, Obara K, Ikeda R, Ishii M, Tanabe Y, Ishikawa T, Nakayama K
Pflugers Arch. 2006
PubMed ID: 16244881
Endothelin-1 impairs glucose transporter trafficking via a membrane-based mechanism.
Strawbridge AB, Elmendorf JS
J Cell Biochem. 2006
PubMed ID: 16240321
GLUT4 repression in response to oxidative stress is associated with reciprocal alterations in C/EBP alpha and delta isoforms in 3T3-L1 adipocytes.
Pessler-Cohen D, Pekala PH, Kovsan J, Bloch-Damti A, Rudich A, Bashan N
Arch Physiol Biochem. 2006
PubMed ID: 16754198
Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism.
Li Y, Wang P, Xu J, Desir GV
Am J Physiol Cell Physiol. 2006
PubMed ID: 16403947
Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha.
Barros RP, Machado UF, Warner M, Gustafsson JA
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16423895
GLUT4 distribution between the plasma membrane and the intracellular compartments is maintained by an insulin-modulated bipartite dynamic mechanism.
Martin OJ, Lee A, McGraw TE
J Biol Chem. 2006
PubMed ID: 16269413
TCDD suppresses insulin-responsive glucose transporter (GLUT-4) gene expression through C/EBP nuclear transcription factors in 3T3-L1 adipocytes.
Liu PC, Matsumura F
J Biochem Mol Toxicol. 2006
PubMed ID: 16615095
Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).
Foster LJ, Rudich A, Talior I, Patel N, Huang X, Furtado LM, Bilan PJ, Mann M, Klip A
J Proteome Res. 2006
PubMed ID: 16396496
Retinoic acids increase expression of GLUT4 in dedifferentiated and hypertrophied cardiac myocytes.
Montessuit C, Papageorgiou I, Campos L, Lerch R
Basic Res Cardiol. 2006
PubMed ID: 16273324
Glycogen overload by postexercise insulin administration abolished the exercise-induced increase in GLUT4 protein.
Chou CH, Tsai YL, Hou CW, Lee HH, Chang WH, Lin TW, Hsu TH, Huang YJ, Kuo CH
J Biomed Sci. 2005
PubMed ID: 16319996
Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking.
Larance M, Ramm G, Stöckli J, van Dam EM, Winata S, Wasinger V, Simpson F, Graham M, Junutula JR, Guilhaus M, James DE
J Biol Chem. 2005
PubMed ID: 16154996
Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism.
Kim YB, Peroni OD, Aschenbach WG, Minokoshi Y, Kotani K, Zisman A, Kahn CR, Goodyear LJ, Kahn BB
Mol Cell Biol. 2005
PubMed ID: 16227617
Free fatty acids repress the GLUT4 gene expression in cardiac muscle via novel response elements.
Armoni M, Harel C, Bar-Yoseph F, Milo S, Karnieli E
J Biol Chem. 2005
PubMed ID: 16096283
Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein.
Eguez L, Lee A, Chavez JA, Miinea CP, Kane S, Lienhard GE, McGraw TE
Cell Metab. 2005
PubMed ID: 16213228
Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle.
Carvalho E, Kotani K, Peroni OD, Kahn BB
Am J Physiol Endocrinol Metab. 2005
PubMed ID: 15928024
Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes.
Yamaguchi S, Katahira H, Ozawa S, Nakamichi Y, Tanaka T, Shimoyama T, Takahashi K, Yoshimoto K, Imaizumi MO, Nagamatsu S, Ishida H
Am J Physiol Endocrinol Metab. 2005
PubMed ID: 15928020
Calmodulin binds to the Rab GTPase activating protein required for insulin-stimulated GLUT4 translocation.
Kane S, Lienhard GE
Biochem Biophys Res Commun. 2005
PubMed ID: 16055084
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Insulin signaling meets vesicle traffic of GLUT4 at a plasma-membrane-activated fusion step.
Koumanov F, Jin B, Yang J, Holman GD
Cell Metab. 2005
PubMed ID: 16154100
Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2.
Nakagawa O, Arnold M, Nakagawa M, Hamada H, Shelton JM, Kusano H, Harris TM, Childs G, Campbell KP, Richardson JA, Nishino I, Olson EN
Genes Dev. 2005
PubMed ID: 16140986
NF-kappaB, MEF2A, MEF2D and HIF1-a involvement on insulin- and contraction-induced regulation of GLUT4 gene expression in soleus muscle.
Silva JL, Giannocco G, Furuya DT, Lima GA, Moraes PA, Nachef S, Bordin S, Britto LR, Nunes MT, Machado UF
Mol Cell Endocrinol. 2005
PubMed ID: 16024167
CCAAT/enhancer binding protein alpha maintains the ability of insulin-stimulated GLUT4 translocation in 3T3-C2 fibroblastic cells.
Fujimoto M, Masuzaki H, Yamamoto Y, Norisada N, Imori M, Yoshimoto M, Tomita T, Tanaka T, Okazawa K, Fujikura J, Chusho H, Ebihara K, Hayashi T, Hosoda K, Inoue G, Nakao K
Biochim Biophys Acta. 2005
PubMed ID: 16085053
Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides.
Ishiki M, Randhawa VK, Poon V, Jebailey L, Klip A
J Biol Chem. 2005
PubMed ID: 15955810
Maternal food restriction enhances insulin-induced GLUT-4 translocation and insulin signaling pathway in skeletal muscle from suckling rats.
Gavete ML, Martín MA, Alvarez C, Escrivá F
Endocrinology. 2005
PubMed ID: 15905322
GLUT4 facilitative glucose transporter specifically and differentially contributes to agonist-induced vascular reactivity in mouse aorta.
Park JL, Loberg RD, Duquaine D, Zhang H, Deo BK, Ardanaz N, Coyle J, Atkins KB, Schin M, Charron MJ, Kumagai AK, Pagano PJ, Brosius FC
Arterioscler Thromb Vasc Biol. 2005
PubMed ID: 15890973
Golgi-localized, gamma-ear-containing, Arf-binding protein adaptors mediate insulin-responsive trafficking of glucose transporter 4 in 3T3-L1 adipocytes.
Li LV, Kandror KV
Mol Endocrinol. 2005
PubMed ID: 15774496
Demonstration of differential quantitative requirements for NSF among multiple vesicle fusion pathways of GLUT4 using a dominant-negative ATPase-deficient NSF.
Chen X, Matsumoto H, Hinck CS, Al-Hasani H, St-Denis JF, Whiteheart SW, Cushman SW
Biochem Biophys Res Commun. 2005
PubMed ID: 15935991
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes.
Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB
Nature. 2005
PubMed ID: 16034410
Subcellular localization of glucose transporter 4 in the hypothalamic arcuate nucleus of ob/ob mice under basal conditions.
Komori T, Morikawa Y, Tamura S, Doi A, Nanjo K, Senba E
Brain Res. 2005
PubMed ID: 15925330
Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes.
Shi J, Kandror KV
Dev Cell. 2005
PubMed ID: 15992544
Localization of the GLUT8 glucose transporter in murine kidney and regulation in vivo in nondiabetic and diabetic conditions.
Schiffer M, Susztak K, Ranalletta M, Raff AC, Böttinger EP, Charron MJ
Am J Physiol Renal Physiol. 2005
PubMed ID: 15741607
Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking.
Hodgkinson CP, Mander A, Sale GJ
Biochem J. 2005
PubMed ID: 15707389
Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1.
Al-Khalili L, Forsgren M, Kannisto K, Zierath JR, Lönnqvist F, Krook A
Diabetologia. 2005
PubMed ID: 15864539
p115 Interacts with the GLUT4 vesicle protein, IRAP, and plays a critical role in insulin-stimulated GLUT4 translocation.
Hosaka T, Brooks CC, Presman E, Kim SK, Zhang Z, Breen M, Gross DN, Sztul E, Pilch PF
Mol Biol Cell. 2005
PubMed ID: 15800058
Insulin-stimulated plasma membrane fusion of Glut4 glucose transporter-containing vesicles is regulated by phospholipase D1.
Huang P, Altshuller YM, Hou JC, Pessin JE, Frohman MA
Mol Biol Cell. 2005
PubMed ID: 15772157
Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.
Huang C, Thirone AC, Huang X, Klip A
J Biol Chem. 2005
PubMed ID: 15764603
Insulin stimulates the halting, tethering, and fusion of mobile GLUT4 vesicles in rat adipose cells.
Lizunov VA, Matsumoto H, Zimmerberg J, Cushman SW, Frolov VA
J Cell Biol. 2005
PubMed ID: 15866888
5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics.
Barnes BR, Glund S, Long YC, Hjälm G, Andersson L, Zierath JR
FASEB J. 2005
PubMed ID: 15857891
GLUT4 expression and subcellular localization in the intrauterine growth-restricted adult rat female offspring.
Thamotharan M, Shin BC, Suddirikku DT, Thamotharan S, Garg M, Devaskar SU
Am J Physiol Endocrinol Metab. 2005
PubMed ID: 15625086
Calorie restriction improves whole-body glucose disposal and insulin resistance in association with the increased adipocyte-specific GLUT4 expression in Otsuka Long-Evans Tokushima fatty rats.
Park SY, Choi GH, Choi HI, Ryu J, Jung CY, Lee W
Arch Biochem Biophys. 2005
PubMed ID: 15797240
Altered hepatic and muscle substrate utilization provoked by GLUT4 ablation.
Ranalletta M, Jiang H, Li J, Tsao TS, Stenbit AE, Yokoyama M, Katz EB, Charron MJ
Diabetes. 2005
PubMed ID: 15793230
Akt activation is required at a late stage of insulin-induced GLUT4 translocation to the plasma membrane.
van Dam EM, Govers R, James DE
Mol Endocrinol. 2005
PubMed ID: 15650020
GLUT4 expression in 3T3-L1 adipocytes is repressed by proteasome inhibition, but not by inhibition of calpains.
Cooke DW, Patel YM
Mol Cell Endocrinol. 2005
PubMed ID: 15737467
Depletion of mitochondrial DNA causes impaired glucose utilization and insulin resistance in L6 GLUT4myc myocytes.
Park SY, Choi GH, Choi HI, Ryu J, Jung CY, Lee W
J Biol Chem. 2005
PubMed ID: 15764607
Calcineurin does not mediate exercise-induced increase in muscle GLUT4.
Garcia-Roves PM, Jones TE, Otani K, Han DH, Holloszy JO
Diabetes. 2005
PubMed ID: 15734836
Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats.
Collison M, James DJ, Graham D, Holman GD, Connell JM, Dominiczak AF, Gould GW, Salt IP
Diabetologia. 2005
PubMed ID: 15729573
Insulin and contraction stimulate exocytosis, but increased AMP-activated protein kinase activity resulting from oxidative metabolism stress slows endocytosis of GLUT4 in cardiomyocytes.
Yang J, Holman GD
J Biol Chem. 2005
PubMed ID: 15557332
Evidence for a role of the exocyst in insulin-stimulated Glut4 trafficking in 3T3-L1 adipocytes.
Ewart MA, Clarke M, Kane S, Chamberlain LH, Gould GW
J Biol Chem. 2005
PubMed ID: 15550383
Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization.
Kanda H, Tamori Y, Shinoda H, Yoshikawa M, Sakaue M, Udagawa J, Otani H, Tashiro F, Miyazaki J, Kasuga M
J Clin Invest. 2005
PubMed ID: 15690082
Glucose transporter isoform 4 is expressed in the syncytiotrophoblast of first trimester human placenta.
Ericsson A, Hamark B, Powell TL, Jansson T
Hum Reprod. 2005
PubMed ID: 15528266
Creatine feeding increases GLUT4 expression in rat skeletal muscle.
Ju JS, Smith JL, Oppelt PJ, Fisher JS
Am J Physiol Endocrinol Metab. 2005
PubMed ID: 15494613
Control of exercise-stimulated muscle glucose uptake by GLUT4 is dependent on glucose phosphorylation capacity in the conscious mouse.
Fueger PT, Hess HS, Posey KA, Bracy DP, Pencek RR, Charron MJ, Wasserman DH
J Biol Chem. 2004
PubMed ID: 15456776
Obesity reduces the expression of GLUT4 in the endometrium of normoinsulinemic women affected by the polycystic ovary syndrome.
Mozzanega B, Mioni R, Granzotto M, Chiarelli S, Xamin N, Zuliani L, Sicolo N, Marchesoni D, Vettor R
Ann N Y Acad Sci. 2004
PubMed ID: 15731326
GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.
Kotani K, Peroni OD, Minokoshi Y, Boss O, Kahn BB
J Clin Invest. 2004
PubMed ID: 15578099
Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles.
Berwick DC, Dell GC, Welsh GI, Heesom KJ, Hers I, Fletcher LM, Cooke FT, Tavaré JM
J Cell Sci. 2004
PubMed ID: 15546921
Effect of exercise training on muscle glucose transporter 4 protein and intramuscular lipid content in elderly men with impaired glucose tolerance.
Kim HJ, Lee JS, Kim CK
Eur J Appl Physiol. 2004
PubMed ID: 15480742
Effect of prolonged intermittent hypoxia and exercise training on glucose tolerance and muscle GLUT4 protein expression in rats.
Chiu LL, Chou SW, Cho YM, Ho HY, Ivy JL, Hunt D, Wang PS, Kuo CH
J Biomed Sci. 2004
PubMed ID: 15591781
Regulation of insulin-stimulated muscle glucose uptake in the conscious mouse: role of glucose transport is dependent on glucose phosphorylation capacity.
Fueger PT, Hess HS, Bracy DP, Pencek RR, Posey KA, Charron MJ, Wasserman DH
Endocrinology. 2004
PubMed ID: 15284204
Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation.
Sbrissa D, Ikonomov OC, Strakova J, Shisheva A
Endocrinology. 2004
PubMed ID: 15284192
An angiotensin II AT1 receptor antagonist, telmisartan augments glucose uptake and GLUT4 protein expression in 3T3-L1 adipocytes.
Fujimoto M, Masuzaki H, Tanaka T, Yasue S, Tomita T, Okazawa K, Fujikura J, Chusho H, Ebihara K, Hayashi T, Hosoda K, Nakao K
FEBS Lett. 2004
PubMed ID: 15498586
Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts.
Török D, Patel N, Jebailey L, Thong FS, Randhawa VK, Klip A, Rudich A
J Cell Sci. 2004
PubMed ID: 15466888
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
The cellular fate of glucose and its relevance in type 2 diabetes.
Bouché C, Serdy S, Kahn CR, Goldfine AB
Endocr Rev. 2004
PubMed ID: 15466941
The transcription factor CCAAT/enhancer-binding protein alpha is required for the intracellular retention of GLUT4.
Wertheim N, Cai Z, McGraw TE
J Biol Chem. 2004
PubMed ID: 15277525
Regulation of insulin-responsive aminopeptidase expression and targeting in the insulin-responsive vesicle compartment of glucose transporter isoform 4-deficient cardiomyocytes.
Abel ED, Graveleau C, Betuing S, Pham M, Reay PA, Kandror V, Kupriyanova T, Xu Z, Kandror KV
Mol Endocrinol. 2004
PubMed ID: 15231875
AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle.
Holmes BF, Lang DB, Birnbaum MJ, Mu J, Dohm GL
Am J Physiol Endocrinol Metab. 2004
PubMed ID: 15165992
Disruption of cortical actin in skeletal muscle demonstrates an essential role of the cytoskeleton in glucose transporter 4 translocation in insulin-sensitive tissues.
Brozinick JT, Hawkins ED, Strawbridge AB, Elmendorf JS
J Biol Chem. 2004
PubMed ID: 15247264
Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes.
Guilherme A, Soriano NA, Furcinitti PS, Czech MP
J Biol Chem. 2004
PubMed ID: 15247266
RNAi-based analysis of CAP, Cbl, and CrkII function in the regulation of GLUT4 by insulin.
Mitra P, Zheng X, Czech MP
J Biol Chem. 2004
PubMed ID: 15258163
Entry of newly synthesized GLUT4 into the insulin-responsive storage compartment is dependent upon both the amino terminus and the large cytoplasmic loop.
Khan AH, Capilla E, Hou JC, Watson RT, Smith JR, Pessin JE
J Biol Chem. 2004
PubMed ID: 15247212
Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects.
Christ-Roberts CY, Pratipanawatr T, Pratipanawatr W, Berria R, Belfort R, Kashyap S, Mandarino LJ
Metabolism. 2004
PubMed ID: 15334390
Separation of insulin signaling into distinct GLUT4 translocation and activation steps.
Funaki M, Randhawa P, Janmey PA
Mol Cell Biol. 2004
PubMed ID: 15314166
Effect of short-term training on GLUT-4 mRNA and protein expression in human skeletal muscle.
Kraniou GN, Cameron-Smith D, Hargreaves M
Exp Physiol. 2004
PubMed ID: 15184360
V-type ATPase is involved in biogenesis of GLUT4 vesicles.
Malikova M, Shi J, Kandror KV
Am J Physiol Endocrinol Metab. 2004
PubMed ID: 15166000
Evidence for the presence of glucose transporter 4 in the endometrium and its regulation in polycystic ovary syndrome patients.
Mioni R, Chiarelli S, Xamin N, Zuliani L, Granzotto M, Mozzanega B, Maffei P, Martini C, Blandamura S, Sicolo N, Vettor R
J Clin Endocrinol Metab. 2004
PubMed ID: 15292352
Glut4 storage vesicles without Glut4: transcriptional regulation of insulin-dependent vesicular traffic.
Gross DN, Farmer SR, Pilch PF
Mol Cell Biol. 2004
PubMed ID: 15282314
Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake.
Sweeney G, Garg RR, Ceddia RB, Li D, Ishiki M, Somwar R, Foster LJ, Neilsen PO, Prestwich GD, Rudich A, Klip A
J Biol Chem. 2004
PubMed ID: 15166230
Phosphatidylinositol 4,5-bisphosphate regulates adipocyte actin dynamics and GLUT4 vesicle recycling.
Kanzaki M, Furukawa M, Raab W, Pessin JE
J Biol Chem. 2004
PubMed ID: 15123724
Insulin increases cell surface GLUT4 levels by dose dependently discharging GLUT4 into a cell surface recycling pathway.
Govers R, Coster AC, James DE
Mol Cell Biol. 2004
PubMed ID: 15226445
EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment.
Park SY, Ha BG, Choi GH, Ryu J, Kim B, Jung CY, Lee W
Biochemistry. 2004
PubMed ID: 15182197
Neomycin prevents the wortmannin inhibition of insulin-stimulated Glut4 translocation and glucose transport in 3T3-L1 adipocytes.
James DJ, Salaün C, Brandie FM, Connell JM, Chamberlain LH
J Biol Chem. 2004
PubMed ID: 15024008
Calpain system regulates muscle mass and glucose transporter GLUT4 turnover.
Otani K, Han DH, Ford EL, Garcia-Roves PM, Ye H, Horikawa Y, Bell GI, Holloszy JO, Polonsky KS
J Biol Chem. 2004
PubMed ID: 15014085
GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase.
Carvalho E, Schellhorn SE, Zabolotny JM, Martin S, Tozzo E, Peroni OD, Houseknecht KL, Mundt A, James DE, Kahn BB
J Biol Chem. 2004
PubMed ID: 14985357
Insulin resistance in adult cardiomyocytes undergoing dedifferentiation: role of GLUT4 expression and translocation.
Rosenblatt-Velin N, Lerch R, Papageorgiou I, Montessuit C
FASEB J. 2004
PubMed ID: 15117888
Annexin II is a thiazolidinedione-responsive gene involved in insulin-induced glucose transporter isoform 4 translocation in 3T3-L1 adipocytes.
Huang J, Hsia SH, Imamura T, Usui I, Olefsky JM
Endocrinology. 2004
PubMed ID: 14726447
Insulin resistance and GLUT-4 glucose transporter in adipocytes from hypertensive rats.
Chiappe De Cingolani GE, Caldiz CI
Metabolism. 2004
PubMed ID: 15015152
Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes.
Holten MK, Zacho M, Gaster M, Juel C, Wojtaszewski JF, Dela F
Diabetes. 2004
PubMed ID: 14747278
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A.
Knight JB, Eyster CA, Griesel BA, Olson AL
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14630949
Threshold effects of glucose transporter-4 (GLUT4) deficiency on cardiac glucose uptake and development of hypertrophy.
Kaczmarczyk SJ, Andrikopoulos S, Favaloro J, Domenighetti AA, Dunn A, Ernst M, Grail D, Fodero-Tavoletti M, Huggins CE, Delbridge LM, Zajac JD, Proietto J
J Mol Endocrinol. 2003
PubMed ID: 14664706
Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha.
Dalen KT, Ulven SM, Bamberg K, Gustafsson JA, Nebb HI
J Biol Chem. 2003
PubMed ID: 12970362
Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action.
MaCaulay SL, Stoichevska V, Grusovin J, Gough KH, Castelli LA, Ward CW
Biochem J. 2003
PubMed ID: 12917015
Glucose transporter content and glucose uptake in skeletal muscle constructs engineered in vitro.
Baker EL, Dennis RG, Larkin LM
In Vitro Cell Dev Biol Anim. 2003
PubMed ID: 14741039
Differential regulation of the muscle-specific GLUT4 enhancer in regenerating and adult skeletal muscle.
Moreno H, Serrano AL, Santalucía T, Gumá A, Cantó C, Brand NJ, Palacin M, Schiaffino S, Zorzano A
J Biol Chem. 2003
PubMed ID: 12893821
Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking.
Bogan JS, Hendon N, McKee AE, Tsao TS, Lodish HF
Nature. 2003
PubMed ID: 14562105
Prevention of glycogen supercompensation prolongs the increase in muscle GLUT4 after exercise.
Garcia-Roves PM, Han DH, Song Z, Jones TE, Hucker KA, Holloszy JO
Am J Physiol Endocrinol Metab. 2003
PubMed ID: 12799316
The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport.
Liu J, DeYoung SM, Hwang JB, O'Leary EE, Saltiel AR
J Biol Chem. 2003
PubMed ID: 12842890
Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation.
Widberg CH, Bryant NJ, Girotti M, Rea S, James DE
J Biol Chem. 2003
PubMed ID: 12832401
Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis.
Minokoshi Y, Kahn CR, Kahn BB
J Biol Chem. 2003
PubMed ID: 12788932
Overexpression of peroxisome proliferator-activated receptor gamma coactivator-1alpha down-regulates GLUT4 mRNA in skeletal muscles.
Miura S, Kai Y, Ono M, Ezaki O
J Biol Chem. 2003
PubMed ID: 12777397
Peroxisome proliferator-activated receptor-gamma represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect.
Armoni M, Kritz N, Harel C, Bar-Yoseph F, Chen H, Quon MJ, Karnieli E
J Biol Chem. 2003
PubMed ID: 12777391
Insulin recruits GLUT4 from distinct compartments via distinct traffic pathways with differential microtubule dependence in rat adipocytes.
Liu LB, Omata W, Kojima I, Shibata H
J Biol Chem. 2003
PubMed ID: 12782634
Variation in type 2 diabetes--related traits in mouse strains susceptible to diet-induced obesity.
Rossmeisl M, Rim JS, Koza RA, Kozak LP
Diabetes. 2003
PubMed ID: 12882911
Syntaxin 6 regulates Glut4 trafficking in 3T3-L1 adipocytes.
Perera HK, Clarke M, Morris NJ, Hong W, Chamberlain LH, Gould GW
Mol Biol Cell. 2003
PubMed ID: 12857877
Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin.
Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM
Mol Cell Biol. 2003
PubMed ID: 12832475
Nitric oxide stimulates glucose transport through insulin-independent GLUT4 translocation in 3T3-L1 adipocytes.
Tanaka T, Nakatani K, Morioka K, Urakawa H, Maruyama N, Kitagawa N, Katsuki A, Araki-Sasaki R, Hori Y, Gabazza EC, Yano Y, Wada H, Nobori T, Sumida Y, Adachi Y
Eur J Endocrinol. 2003
PubMed ID: 12824867
Somatic cell-like features of cloned mouse embryos prepared with cultured myoblast nuclei.
Gao S, Chung YG, Williams JW, Riley J, Moley K, Latham KE
Biol Reprod. 2003
PubMed ID: 12606377
Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis.
Niu W, Huang C, Nawaz Z, Levy M, Somwar R, Li D, Bilan PJ, Klip A
J Biol Chem. 2003
PubMed ID: 12637564
Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules.
Semiz S, Park JG, Nicoloro SM, Furcinitti P, Zhang C, Chawla A, Leszyk J, Czech MP
EMBO J. 2003
PubMed ID: 12743033
GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization.
Burcelin R, Crivelli V, Perrin C, Da Costa A, Mu J, Kahn BB, Birnbaum MJ, Kahn CR, Vollenweider P, Thorens B
J Clin Invest. 2003
PubMed ID: 12750405
5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes.
Koistinen HA, Galuska D, Chibalin AV, Yang J, Zierath JR, Holman GD, Wallberg-Henriksson H
Diabetes. 2003
PubMed ID: 12716734
Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues.
Rudich A, Konrad D, Török D, Ben-Romano R, Huang C, Niu W, Garg RR, Wijesekara N, Germinario RJ, Bilan PJ, Klip A
Diabetologia. 2003
PubMed ID: 12712244
Regulation of GLUT4 expression in vivo and in vitro.
Olson AL, Knight JB
Front Biosci. 2003
PubMed ID: 12700047
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation.
Sano H, Kane S, Sano E, Mîinea CP, Asara JM, Lane WS, Garner CW, Lienhard GE
J Biol Chem. 2003
PubMed ID: 12637568
Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes.
Usui I, Imamura T, Huang J, Satoh H, Olefsky JM
J Biol Chem. 2003
PubMed ID: 12566459
The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin.
Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR
Nature. 2003
PubMed ID: 12687004
Insulin-induced translocation of facilitative glucose transporters in fetal/neonatal rat skeletal muscle.
He J, Thamotharan M, Devaskar SU
Am J Physiol Regul Integr Comp Physiol. 2003
PubMed ID: 12531786
Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles.
Jessen N, Pold R, Buhl ES, Jensen LS, Schmitz O, Lund S
J Appl Physiol. 2003
PubMed ID: 12496137
The adipocyte plasma membrane caveolin functional/structural organization is necessary for the efficient endocytosis of GLUT4.
Shigematsu S, Watson RT, Khan AH, Pessin JE
J Biol Chem. 2003
PubMed ID: 12496259
GLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif.
Shewan AM, van Dam EM, Martin S, Luen TB, Hong W, Bryant NJ, James DE
Mol Biol Cell. 2003
PubMed ID: 12631717
Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression.
Carlson CJ, Koterski S, Sciotti RJ, Poccard GB, Rondinone CM
Diabetes. 2003
PubMed ID: 12606502
Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance.
Hammarstedt A, Jansson PA, Wesslau C, Yang X, Smith U
Biochem Biophys Res Commun. 2003
PubMed ID: 12565902
GLUT4 expression in human muscle fibres is not correlated with intracellular triglyceride (TG) content. Is TG a maker or a marker of insulin resistance?
Gaster M, Ottosen PD, Vach W, Christiansen H, Staehr P, Beck-Nielsen H, Schrøder HD
APMIS. 2003
PubMed ID: 12716391
SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation.
Ijuin T, Takenawa T
Mol Cell Biol. 2003
PubMed ID: 12556481
Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries.
Sakai K, Shimizu H, Koike T, Furuya S, Watanabe M
J Neurosci. 2003
PubMed ID: 12533615
Effect of acid maltase deficiency on the endosomal/lysosomal system and glucose transporter 4.
Orth M, Mundegar RR
Neuromuscul Disord. 2003
PubMed ID: 12467732
A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation.
Somwar R, Koterski S, Sweeney G, Sciotti R, Djuric S, Berg C, Trevillyan J, Scherer PE, Rondinone CM, Klip A
J Biol Chem. 2002
PubMed ID: 12393894
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
The vesicle- and target-SNARE proteins that mediate Glut4 vesicle fusion are localized in detergent-insoluble lipid rafts present on distinct intracellular membranes.
Chamberlain LH, Gould GW
J Biol Chem. 2002
PubMed ID: 12376543
Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c.
Bose A, Guilherme A, Robida SI, Nicoloro SM, Zhou QL, Jiang ZY, Pomerleau DP, Czech MP
Nature. 2002
PubMed ID: 12490950
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Transient changes in four GLUT4 compartments in rat adipocytes during the transition, insulin-stimulated to basal: implications for the GLUT4 trafficking pathway.
Hah JS, Ryu JW, Lee W, Kim BS, Lachaal M, Spangler RA, Jung CY
Biochemistry. 2002
PubMed ID: 12450403
Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytes.
Yang J, Gillingham AK, Hodel A, Koumanov F, Woodward B, Holman GD
Am J Physiol Endocrinol Metab. 2002
PubMed ID: 12388133
Insulin-responsive glucose transporters-GLUT8 and GLUT4 are expressed in the developing mammalian brain.
Sankar R, Thamotharan S, Shin D, Moley KH, Devaskar SU
Brain Res Mol Brain Res. 2002
PubMed ID: 12425944
A Crk-II/TC10 signaling pathway is required for osmotic shock-stimulated glucose transport.
Gual P, Shigematsu S, Kanzaki M, Grémeaux T, Gonzalez T, Pessin JE, Le Marchand-Brustel Y, Tanti JF
J Biol Chem. 2002
PubMed ID: 12215429
Expression of insulin-responsive glucose transporter GLUT4 mRNA in the rat brain and spinal cord: an in situ hybridization study.
El Messari S, Aït-Ikhlef A, Ambroise DH, Penicaud L, Arluison M
J Chem Neuroanat. 2002
PubMed ID: 12406499
Placental glucose transfer and fetal growth.
Baumann MU, Deborde S, Illsley NP
Endocrine. 2002
PubMed ID: 12583599
The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes.
Chang L, Adams RD, Saltiel AR
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12242347
Cellular munc18c levels can modulate glucose transport rate and GLUT4 translocation in 3T3L1 cells.
Macaulay SL, Grusovin J, Stoichevska V, Ryan JM, Castelli LA, Ward CW
FEBS Lett. 2002
PubMed ID: 12297296
The Krüppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4.
Gray S, Feinberg MW, Hull S, Kuo CT, Watanabe M, Sen-Banerjee S, DePina A, Haspel R, Jain MK
J Biol Chem. 2002
PubMed ID: 12097321
GLUT4 protein is differently modulated during development of obesity in monosodium glutamate-treated mice.
de Carvalho Papa P, Vargas AM, da Silva JL, Nunes MT, Machado UF
Life Sci. 2002
PubMed ID: 12175706
Phenotypic characteristics of adipocytes generated from Meckel's chondrocytes in response to chick serum in vitro.
Ishizeki K, Takahashi N, Nawa T
Cell Tissue Res. 2002
PubMed ID: 12172784
NCS-1 inhibits insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes through a phosphatidylinositol 4-kinase-dependent pathway.
Mora S, Durham PL, Smith JR, Russo AF, Jeromin A, Pessin JE
J Biol Chem. 2002
PubMed ID: 12011096
Functional consequence of targeting protein kinase B/Akt to GLUT4 vesicles.
Ducluzeau PH, Fletcher LM, Welsh GI, Tavaré JM
J Cell Sci. 2002
PubMed ID: 12082147
Regulation of glucose transport and transporter 4 (GLUT-4) in muscle and adipocytes of sucrose-fed rats: effects of N-3 poly- and monounsaturated fatty acids.
Peyron-Caso E, Fluteau-Nadler S, Kabir M, Guerre-Millo M, Quignard-Boulangé A, Slama G, Rizkalla SW
Horm Metab Res. 2002
PubMed ID: 12189582
Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity.
Huang C, Somwar R, Patel N, Niu W, Török D, Klip A
Diabetes. 2002
PubMed ID: 12086937
Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha.
Carmona MC, Iglesias R, Obregón MJ, Darlington GJ, Villarroya F, Giralt M
J Biol Chem. 2002
PubMed ID: 11940593
Glucose transporter 4 gene: association studies pertaining to alleles of two polymorphisms in extremely obese children and adolescents and in normal and underweight controls.
Friedel S, Antwerpen B, Hoch A, Vogel C, Grassl W, Geller F, Hebebrand J, Hinney A
Ann N Y Acad Sci. 2002
PubMed ID: 12079888
Terguride treatment attenuated prolactin release and enhanced insulin receptor affinity and GLUT 4 content in obese spontaneously hypertensive female, but not male rats.
Zorad S, Golda V, Fickova M, Macho L, Pinterova L, Jurcovicova J
Ann N Y Acad Sci. 2002
PubMed ID: 12079879
Changes in FAT/CD36, UCP2, UCP3 and GLUT4 gene expression during lipid infusion in rat skeletal and heart muscle.
Vettor R, Fabris R, Serra R, Lombardi AM, Tonello C, Granzotto M, Marzolo MO, Carruba MO, Ricquier D, Federspil G, Nisoli E
Int J Obes Relat Metab Disord. 2002
PubMed ID: 12037655
APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes.
Liu J, Kimura A, Baumann CA, Saltiel AR
Mol Cell Biol. 2002
PubMed ID: 11997497
The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1.
Lalioti VS, Vergarajauregui S, Pulido D, Sandoval IV
J Biol Chem. 2002
PubMed ID: 11842083
Mice deficient in the insulin-regulated membrane aminopeptidase show substantial decreases in glucose transporter GLUT4 levels but maintain normal glucose homeostasis.
Keller SR, Davis AC, Clairmont KB
J Biol Chem. 2002
PubMed ID: 11884418
Interaction of exercise and diet on GLUT-4 protein and gene expression in Type I and Type II rat skeletal muscle.
Lee JS, Bruce CR, Tunstall RJ, Cameron-Smith D, Hugel H, Hawley JA
Acta Physiol Scand. 2002
PubMed ID: 11982503
Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+).
Ojuka EO, Jones TE, Nolte LA, Chen M, Wamhoff BR, Sturek M, Holloszy JO
Am J Physiol Endocrinol Metab. 2002
PubMed ID: 11934664
Detection of insulin-regulated GLUT4-translocation by the insertion of a protein C epitope in L6 myoblasts.
Warolen M, Walum E, Wilcke M
J Biochem Biophys Methods. 2002
PubMed ID: 12062111
Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations.
Murata H, Hruz PW, Mueckler M
AIDS. 2002
PubMed ID: 11919487
Regulated transport of the glucose transporter GLUT4.
Bryant NJ, Govers R, James DE
Nat Rev Mol Cell Biol. 2002
PubMed ID: 11994746
An increase in the myocardial PCr/ATP ratio in GLUT4 null mice.
Weiss RG, Chatham JC, Georgakopolous D, Charron MJ, Wallimann T, Kay L, Walzel B, Wang Y, Kass DA, Gerstenblith G, Chacko VP
FASEB J. 2002
PubMed ID: 11919171
Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D.
Sajan MP, Bandyopadhyay G, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV
Biochem J. 2002
PubMed ID: 11879194
Sustained hypoglycemia affects glucose transporter expression of human blood leukocytes.
Korgun ET, Demir R, Sedlmayr P, Desoye G, Arikan GM, Puerstner P, Haeusler M, Dohr G, Skofitsch G, Hahn T
Blood Cells Mol Dis. 2002
PubMed ID: 12064911
Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by the phosphatidyl-inositol-3-kinase pathway in the rat heart.
Medina RA, Southworth R, Fuller W, Garlick PB
Basic Res Cardiol. 2002
PubMed ID: 12002265
SNARE expression and distribution during 3T3-L1 adipocyte differentiation.
Torrejón-Escribano B, Gómez de Aranda I, Blasi J
FEBS Lett. 2002
PubMed ID: 11852095
Increased muscle fatigability in GLUT-4-deficient mice.
Gorselink M, Drost MR, de Brouwer KF, Schaart G, van Kranenburg GP, Roemen TH, van Bilsen M, Charron MJ, van der Vusse GJ
Am J Physiol Endocrinol Metab. 2002
PubMed ID: 11788366
Downregulation of metabolic gene expression in failing human heart before and after mechanical unloading.
Razeghi P, Young ME, Ying J, Depre C, Uray IP, Kolesar J, Shipley GL, Moravec CS, Davies PJ, Frazier OH, Taegtmeyer H
Cardiology. 2002
PubMed ID: 12145475
Exploring the whereabouts of GLUT4 in skeletal muscle (review).
Ploug T, Ralston E
Mol Membr Biol. 2002
PubMed ID: 11989821
Immunohistochemical localization and quantification of glucose transporters in the mouse brain.
Choeiri C, Staines W, Messier C
Neuroscience. 2002
PubMed ID: 11955709
Insulin signalling and the regulation of glucose and lipid metabolism.
Saltiel AR, Kahn CR
Nature. 2001
PubMed ID: 11742412
Impairment of insulin-stimulated GLUT4 translocation in skeletal muscle and adipose tissue in the Tsumura Suzuki obese diabetic mouse: a new genetic animal model of type 2 diabetes.
Miura T, Suzuki W, Ishihara E, Arai I, Ishida H, Seino Y, Tanigawa K
Eur J Endocrinol. 2001
PubMed ID: 11720905
A novel functional co-operation between MyoD, MEF2 and TRalpha1 is sufficient for the induction of GLUT4 gene transcription.
Santalucía T, Moreno H, Palacín M, Yacoub MH, Brand NJ, Zorzano A
J Mol Biol. 2001
PubMed ID: 11718554
PTEN does not modulate GLUT4 translocation in rat adipose cells under physiological conditions.
Mosser VA, Li Y, Quon MJ
Biochem Biophys Res Commun. 2001
PubMed ID: 11689011
GLUT-4 translocation in skeletal muscle studied with a cell-free assay: involvement of phospholipase D.
Kristiansen S, Nielsen JN, Bourgoin S, Klip A, Franco M, Richter EA
Am J Physiol Endocrinol Metab. 2001
PubMed ID: 11500317
A Glut4-vesicle marker protein, insulin-responsive aminopeptidase, is localized in a novel vesicular compartment in PC12 cells.
Thoidis G, Kandror KV
Traffic. 2001
PubMed ID: 11489215
GLUT4: a key player regulating glucose homeostasis? Insights from transgenic and knockout mice (review).
Wallberg-Henriksson H, Zierath JR
Mol Membr Biol. 2001
PubMed ID: 11681787
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4.
Kim JK, Zisman A, Fillmore JJ, Peroni OD, Kotani K, Perret P, Zong H, Dong J, Kahn CR, Kahn BB, Shulman GI
J Clin Invest. 2001
PubMed ID: 11435467
Responses of GLUT4-deficient hearts to ischemia underscore the importance of glycolysis.
Tian R, Abel ED
Circulation. 2001
PubMed ID: 11413087
GLUT4 ablation in mice results in redistribution of IRAP to the plasma membrane.
Jiang H, Li J, Katz EB, Charron MJ
Biochem Biophys Res Commun. 2001
PubMed ID: 11394912
GLUT4 overexpression in db/db mice dose-dependently ameliorates diabetes but is not a lifelong cure.
Brozinick JT, McCoid SC, Reynolds TH, Nardone NA, Hargrove DM, Stevenson RW, Cushman SW, Gibbs EM
Diabetes. 2001
PubMed ID: 11246879
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver.
Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB
Nature. 2001
PubMed ID: 11217863
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Structure and chromosome location of the mouse P2X(1) purinoceptor gene (P2rx1).
Liang SX, Jenkins NA, Gilbert DJ, Copeland NG, Phillips WD
Cytogenet Cell Genet. 2001
PubMed ID: 11435708
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Mechanism and regulation of GLUT-4 vesicle fusion in muscle and fat cells.
Foster LJ, Klip A
Am J Physiol Cell Physiol. 2000
PubMed ID: 11003568
C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue.
Chen SS, Chen JF, Johnson PF, Muppala V, Lee YH
Mol Cell Biol. 2000
PubMed ID: 10982846
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.
Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, Kahn BB
Nat Med. 2000
PubMed ID: 10932232
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Preservation of glucose metabolism in hypertrophic GLUT4-null hearts.
Stenbit AE, Katz EB, Chatham JC, Geenen DL, Factor SM, Weiss RG, Tsao TS, Malhotra A, Chacko VP, Ocampo C, Jelicks LA, Charron MJ
Am J Physiol Heart Circ Physiol. 2000
PubMed ID: 10899071
Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice.
Li J, Houseknecht KL, Stenbit AE, Katz EB, Charron MJ
FASEB J. 2000
PubMed ID: 10834933
The sentrin-conjugating enzyme mUbc9 interacts with GLUT4 and GLUT1 glucose transporters and regulates transporter levels in skeletal muscle cells.
Giorgino F, de Robertis O, Laviola L, Montrone C, Perrini S, McCowen KC, Smith RJ
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10655495
Prenatal expression of the GLUT4 glucose transporter in the mouse.
Vannucci SJ, Rutherford T, Wilkie MB, Simpson IA, Lauder JM
Dev Neurosci. 2000
PubMed ID: 10965149
Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart.
Abel ED, Kaulbach HC, Tian R, Hopkins JC, Duffy J, Doetschman T, Minnemann T, Boers ME, Hadro E, Oberste-Berghaus C, Quist W, Lowell BB, Ingwall JS, Kahn BB
J Clin Invest. 1999
PubMed ID: 10606624
Postexercise glucose uptake and glycogen synthesis in skeletal muscle from GLUT4-deficient mice.
Ryder JW, Kawano Y, Galuska D, Fahlman R, Wallberg-Henriksson H, Charron MJ, Zierath JR
FASEB J. 1999
PubMed ID: 10593872
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance.
Kubota N, Terauchi Y, Miki H, Tamemoto H, Yamauchi T, Komeda K, Satoh S, Nakano R, Ishii C, Sugiyama T, Eto K, Tsubamoto Y, Okuno A, Murakami K, Sekihara H, Hasegawa G, Naito M, Toyoshima Y, Tanaka S, Shiota K, Kitamura T, Fujita T, Ezaki O, Aizawa S, Kadowaki T
Mol Cell. 1999
PubMed ID: 10549291
In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle.
Ryder JW, Kawano Y, Chibalin AV, Rincón J, Tsao TS, Stenbit AE, Combatsiaris T, Yang J, Holman GD, Charron MJ, Zierath JR
Biochem J. 1999
PubMed ID: 10455018
Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4.
Bogan JS, Lodish HF
J Cell Biol. 1999
PubMed ID: 10444069
Effects of overexpression of human GLUT4 gene on maternal diabetes and fetal growth in spontaneous gestational diabetic C57BLKS/J Lepr(db/+) mice.
Ishizuka T, Klepcyk P, Liu S, Panko L, Liu S, Gibbs EM, Friedman JE
Diabetes. 1999
PubMed ID: 10331411
Overexpression of GLUT4 in mice causes up-regulation of UCP3 mRNA in skeletal muscle.
Tsuboyama-Kasaoka N, Tsunoda N, Maruyama K, Takahashi M, Kim H, Cooke DW, Lane MD, Ezaki O
Biochem Biophys Res Commun. 1999
PubMed ID: 10222258
Prevention of insulin resistance and diabetes in mice heterozygous for GLUT4 ablation by transgenic complementation of GLUT4 in skeletal muscle.
Tsao TS, Stenbit AE, Factor SM, Chen W, Rossetti L, Charron MJ
Diabetes. 1999
PubMed ID: 10102694
Cloning of an L-3-hydroxyacyl-CoA dehydrogenase that interacts with the GLUT4 C-terminus.
Shi Y, Samuel SJ, Lee W, Yu C, Zhang W, Lachaal M, Jung CY
Arch Biochem Biophys. 1999
PubMed ID: 10068455
SNAP-23 participates in SNARE complex assembly in rat adipose cells.
St-Denis JF, Cabaniols JP, Cushman SW, Roche PA
Biochem J. 1999
PubMed ID: 10051443
GLUT4 gene regulation and manipulation.
Charron MJ, Katz EB, Olson AL
J Biol Chem. 1999
PubMed ID: 9920861
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase.
Terauchi Y, Tsuji Y, Satoh S, Minoura H, Murakami K, Okuno A, Inukai K, Asano T, Kaburagi Y, Ueki K, Nakajima H, Hanafusa T, Matsuzawa Y, Sekihara H, Yin Y, Barrett JC, Oda H, Ishikawa T, Akanuma Y, Komuro I, Suzuki M, Yamamura K, Kodama T, Suzuki H, Yamamura K, Kodama T, Suzuki H, Koyasu S, Aizawa S, Tobe K, Fukui Y, Yazaki Y, Kadowaki T
Nat Genet. 1999
PubMed ID: 9988280
Akt-2 binds to Glut4-containing vesicles and phosphorylates their component proteins in response to insulin.
Kupriyanova TA, Kandror KV
J Biol Chem. 1999
PubMed ID: 9880520
Age-associated alterations in cardiac and skeletal muscle glucose transporters, insulin and IGF-1 receptors, and PI3-kinase protein contents in the C57BL/6 mouse.
Martineau LC, Chadan SG, Parkhouse WS
Mech Ageing Dev. 1999
PubMed ID: 10100151
Insulin-sensitive regulation of glucose transport and GLUT4 translocation in skeletal muscle of GLUT1 transgenic mice.
Etgen GJ, Zavadoski WJ, Holman GD, Gibbs EM
Biochem J. 1999
PubMed ID: 9854024
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Ko MS, Threat TA, Wang X, Horton JH, Cui Y, Wang X, Pryor E, Paris J, Wells-Smith J, Kitchen JR, Rowe LB, Eppig J, Satoh T, Brant L, Fujiwara H, Yotsumoto S, Nakashima H
Hum Mol Genet. 1998
PubMed ID: 9811942
Modulation of 17alpha-hydroxylase/17,20-lyase activity of guinea pig cytochrome P450c17 by site-directed mutagenesis.
Beaudoin C, Lavallée B, Tremblay Y, Hum DW, Breton R, de Launoit Y, Bélanger A
DNA Cell Biol. 1998
PubMed ID: 9726253
GLUT4 glucose transporter expression in rodent brain: effect of diabetes.
Vannucci SJ, Koehler-Stec EM, Li K, Reynolds TH, Clark R, Simpson IA
Brain Res. 1998
PubMed ID: 9630471
Transcriptional regulation of muscle-specific genes during myoblast differentiation.
Shimokawa T, Kato M, Ezaki O, Hashimoto S
Biochem Biophys Res Commun. 1998
PubMed ID: 9600108
Insulin increases the association of Akt-2 with Glut4-containing vesicles.
Calera MR, Martinez C, Liu H, Jack AK, Birnbaum MJ, Pilch PF
J Biol Chem. 1998
PubMed ID: 9516411
Intestinal maturation in mice lacking CCAAT/enhancer-binding protein alpha (C/EPBalpha).
Oesterreicher TJ, Leeper LL, Finegold MJ, Darlington GJ, Henning SJ
Biochem J. 1998
PubMed ID: 9494081
cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.
Shindo M, Nakano H, Kuroyanagi H, Shirasawa T, Mihara M, Gilbert DJ, Jenkins NA, Copeland NG, Yagita H, Okumura K
Biochem Biophys Res Commun. 1998
PubMed ID: 9514916
Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes.
Morris NJ, Ross SA, Lane WS, Moestrup SK, Petersen CM, Keller SR, Lienhard GE
J Biol Chem. 1998
PubMed ID: 9452485
PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes.
Wu Z, Xie Y, Morrison RF, Bucher NL, Farmer SR
J Clin Invest. 1998
PubMed ID: 9421462
A myosin-derived peptide C109 binds to GLUT4-vesicles and inhibits the insulin-induced glucose transport stimulation and GLUT4 recruitment in rat adipocytes.
Lee W, Samuel J, Zhang W, Rampal AL, Lachaal M, Jung CY
Biochem Biophys Res Commun. 1997
PubMed ID: 9388492
Phenotype of transgenic mice overexpressing GLUT4 and hexokinase II in muscle.
Lombardi AM, Moller D, Loizeau M, Girard J, Leturque A
FASEB J. 1997
PubMed ID: 9367348
GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes.
Stenbit AE, Tsao TS, Li J, Burcelin R, Geenen DL, Factor SM, Houseknecht K, Katz EB, Charron MJ
Nat Med. 1997
PubMed ID: 9334720
Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene.
Rossetti L, Stenbit AE, Chen W, Hu M, Barzilai N, Katz EB, Charron MJ
J Clin Invest. 1997
PubMed ID: 9312184
Identification and characterization of two distinct intracellular GLUT4 pools in rat skeletal muscle: evidence for an endosomal and an insulin-sensitive GLUT4 compartment.
Aledo JC, Lavoie L, Volchuk A, Keller SR, Klip A, Hundal HS
Biochem J. 1997
PubMed ID: 9271094
Muscle-specific transgenic complementation of GLUT4-deficient mice. Effects on glucose but not lipid metabolism.
Tsao TS, Stenbit AE, Li J, Houseknecht KL, Zierath JR, Katz EB, Charron MJ
J Clin Invest. 1997
PubMed ID: 9239415
Vp165 and GLUT4 share similar vesicle pools along their trafficking pathways in rat adipose cells.
Malide D, St-Denis JF, Keller SR, Cushman SW
FEBS Lett. 1997
PubMed ID: 9224710
Physical and linkage mapping of human chromosome 17 loci to dog chromosomes 9 and 5.
Werner P, Raducha MG, Prociuk U, Henthorn PS, Patterson DF
Genomics. 1997
PubMed ID: 9177778
Characterization of rat Glut4 glucose transporter expressed in the yeast Saccharomyces cerevisiae: comparison with Glut1 glucose transporter.
Kasahara T, Kasahara M
Biochim Biophys Acta. 1997
PubMed ID: 9059504
Regulation of cell surface GLUT4 in skeletal muscle of transgenic mice.
Brozinick JT, McCoid SC, Reynolds TH, Wilson CM, Stevenson RW, Cushman SW, Gibbs EM
Biochem J. 1997
PubMed ID: 9003403
The metabolic consequences of altered glucose transporter expression in transgenic mice.
Katz EB, Burcelin R, Tsao TS, Stenbit AE, Charron MJ
J Mol Med. 1996
PubMed ID: 8956150
Muscle subcellular localization and recruitment by insulin of glucose transporters and Na+-K+-ATPase subunits in transgenic mice overexpressing the GLUT4 glucose transporter.
Ramlal T, Ewart HS, Somwar R, Deems RO, Valentin MA, Young DA, Klip A
Diabetes. 1996
PubMed ID: 8866555
Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes.
Long SD, Pekala PH
Biochem J. 1996
PubMed ID: 8870666
Differential effects of GLUT1 or GLUT4 overexpression on hexosamine biosynthesis by muscles of transgenic mice.
Buse MG, Robinson KA, Marshall BA, Mueckler M
J Biol Chem. 1996
PubMed ID: 8798515
Multiple mouse chromosomal loci for dynein-based motility.
Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB
Genomics. 1996
PubMed ID: 8812413
The glucose transporter (GLUT-4) and vesicle-associated membrane protein-2 (VAMP-2) are segregated from recycling endosomes in insulin-sensitive cells.
Martin S, Tellam J, Livingstone C, Slot JW, Gould GW, James DE
J Cell Biol. 1996
PubMed ID: 8707843
Diverse effects of Glut 4 ablation on glucose uptake and glycogen synthesis in red and white skeletal muscle.
Stenbit AE, Burcelin R, Katz EB, Tsao TS, Gautier N, Charron MJ, Le Marchand-Brustel Y
J Clin Invest. 1996
PubMed ID: 8698853
Glut4 is targeted to specific vesicles in adipocytes of transgenic mice overexpressing Glut4 selectively in adipose tissue.
Tozzo E, Kahn BB, Pilch PF, Kandror KV
J Biol Chem. 1996
PubMed ID: 8631845
Derivation and characterization of a somatic cell hybrid containing the portion of mouse chromosome 11 (MMU11) homologous to human chromosome 17q.
Morris-Rosendahl DJ, Schriever-Schwemmer G, Robinson TJ
J Hered. 1996
PubMed ID: 8683100
Regulation of GLUT4 mRNA stability by tumor necrosis factor-alpha: alterations in both protein binding to the 3' untranslated region and initiation of translation.
Long SD, Pekala PH
Biochem Biophys Res Commun. 1996
PubMed ID: 8607873
Glucose transport and GLUT4 protein distribution in skeletal muscle of GLUT4 transgenic mice.
Brozinick JT, Yaspelkis BB, Wilson CM, Grant KE, Gibbs EM, Cushman SW, Ivy JL
Biochem J. 1996
PubMed ID: 8546674
Differential effects of insulin and exercise on Rab4 distribution in rat skeletal muscle.
Sherman LA, Hirshman MF, Cormont M, Le Marchand-Brustel Y, Goodyear LJ
Endocrinology. 1996
PubMed ID: 8536622
Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4.
Katz EB, Stenbit AE, Hatton K, DePinho R, Charron MJ
Nature. 1995
PubMed ID: 7675081
Transgenic GLUT-4 overexpression in fat enhances glucose metabolism: preferential effect on fatty acid synthesis.
Tozzo E, Shepherd PR, Gnudi L, Kahn BB
Am J Physiol. 1995
PubMed ID: 7762651
Characterization of 5'-heterogeneity of the rat GLUT4/muscle-adipose glucose transporter gene product.
Olson AL, Edgington NP, Moye-Rowley WS, Pessin JE
Endocrinology. 1995
PubMed ID: 7720644
High fat diet-induced hyperglycemia: prevention by low level expression of a glucose transporter (GLUT4) minigene in transgenic mice.
Ikemoto S, Thompson KS, Takahashi M, Itakura H, Lane MD, Ezaki O
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7724522
Cellubrevin is a resident protein of insulin-sensitive GLUT4 glucose transporter vesicles in 3T3-L1 adipocytes.
Volchuk A, Sargeant R, Sumitani S, Liu Z, He L, Klip A
J Biol Chem. 1995
PubMed ID: 7713930
A high-resolution map of the chromosomal region surrounding the nude gene.
Blackburn CC, Griffith J, Morahan G
Genomics. 1995
PubMed ID: 7601457
The effect of adipose cell size on the measurement of GLUT 4 in white adipose tissue of obese mice.
Fabres-Machado U, Saito M
Braz J Med Biol Res. 1995
PubMed ID: 8520534
Skeletal muscle glucose transport and metabolism are enhanced in transgenic mice overexpressing the Glut4 glucose transporter.
Hansen PA, Gulve EA, Marshall BA, Gao J, Pessin JE, Holloszy JO, Mueckler M
J Biol Chem. 1995
PubMed ID: 7829503
Myocyte enhancer factor 2 (MEF2) binding site is essential for C2C12 myotube-specific expression of the rat GLUT4/muscle-adipose facilitative glucose transporter gene.
Liu ML, Olson AL, Edgington NP, Moye-Rowley WS, Pessin JE
J Biol Chem. 1994
PubMed ID: 7545962
Differential effects of GLUT-1 or GLUT-4 overexpression on insulin responsiveness in transgenic mice.
Marshall BA, Mueckler MM
Am J Physiol. 1994
PubMed ID: 7977725
Insulin resistance, diabetes, and the insulin-regulated trafficking of GLUT-4.
James DE, Piper RC
J Cell Biol. 1994
PubMed ID: 8063851
Insulin-induced translocation of the glucose transporter GLUT4 in cardiac muscle: studies on the role of small-molecular-mass GTP-binding proteins.
Uphues I, Kolter T, Goud B, Eckel J
Biochem J. 1994
PubMed ID: 8037667
Parallel changes in Glut 4 and Rab4 movements in two insulin-resistant states.
Ricort JM, Tanti JF, Cormont M, Van Obberghen E, Le Marchand-Brustel Y
FEBS Lett. 1994
PubMed ID: 8013658
Reduced content and preserved translocation of glucose transporter (GLUT 4) in white adipose tissue of obese mice.
Machado UF, Shimizu I, Saito M
Physiol Behav. 1994
PubMed ID: 8190786
mgl-1, a mouse homologue of the Drosophila tumor-suppressor gene l(2)gl, maps to chromosome 11.
Kuwabara K, Takahashi Y, Tomotsune D, Takahashi N, Kominami R
Genomics. 1994
PubMed ID: 8020994
A Leu-Leu sequence is essential for COOH-terminal targeting signal of GLUT4 glucose transporter in fibroblasts.
Verhey KJ, Birnbaum MJ
J Biol Chem. 1994
PubMed ID: 8300557
The glucose transporter family: structure, function and tissue-specific expression.
Gould GW, Holman GD
Biochem J. 1993
PubMed ID: 8240230
Insulin and okadaic acid induce Rab4 redistribution in adipocytes.
Cormont M, Tanti JF, Zahraoui A, Van Obberghen E, Tavitian A, Le Marchand-Brustel Y
J Biol Chem. 1993
PubMed ID: 8366094
Identification of the 5' end of the gene encoding a human insulin-responsive glucose transporter.
Chiaramonte R, Martini R, Taramelli R, Comi P
Gene. 1993
PubMed ID: 7916714
Cloning and chromosomal mapping of mouse seminal vesicle protein F.
Yoo-Warren H, Willse AG, Hull J, Brownell E
J Exp Zool. 1993
PubMed ID: 8487016
Expression of the glucose transporter GLUT4 in the muscular dystrophic mdx mouse.
Olichon-Berthe C, Gautier N, Van Obberghen E, Le Marchand-Brustel Y
Biochem J. 1993
PubMed ID: 8471042
Somatic cell hybrid mapping on mouse chromosome 11 (MMU11): assignment of markers relative to two breakpoints in band D.
Morris DJ, Adler ID, Robinson TJ
Genomics. 1993
PubMed ID: 8449498
Effect of cold acclimation on the expression of glucose transporter Glut 4.
Olichon-Berthe C, Van Obberghen E, Le Marchand-Brustel Y
Mol Cell Endocrinol. 1992
PubMed ID: 1301380
Differential screening of a PCR-generated mouse embryo cDNA library: glucose transporters are differentially expressed in early postimplantation mouse embryos.
Smith DE, Gridley T
Development. 1992
PubMed ID: 1289053
Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis.
Stephens JM, Pekala PH
J Biol Chem. 1992
PubMed ID: 1618860
Expression and regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice.
Liu ML, Olson AL, Moye-Rowley WS, Buse JB, Bell GI, Pessin JE
J Biol Chem. 1992
PubMed ID: 1601840
Developmental expression and cellular localization of glucose transporter molecules during mouse preimplantation development.
Aghayan M, Rao LV, Smith RM, Jarett L, Charron MJ, Thorens B, Heyner S
Development. 1992
PubMed ID: 1638987
Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population.
O'Rahilly S, Krook A, Morgan R, Rees A, Flier JS, Moller DE
Diabetologia. 1992
PubMed ID: 1521731
Expression of the glucose transporter isoform GLUT 4 is insufficient to confer insulin-regulatable hexose uptake to cultured muscle cells.
Kotliar N, Pilch PF
Mol Endocrinol. 1992
PubMed ID: 1584210
Exercise training, glucose transporters, and glucose transport in rat skeletal muscles.
Rodnick KJ, Henriksen EJ, James DE, Holloszy JO
Am J Physiol. 1992
PubMed ID: 1733237
Linkage analysis of 84 microsatellite markers in intra- and interspecific backcrosses.
McAleer MA, Aitman TJ, Cornall RJ, Ghosh S, Hall JR, Hearne CM, Love JM, Prins JB, Ramachandran S, Rodrigues N
Mamm Genome. 1992
PubMed ID: 1643308
PCR-analyzed microsatellites of the mouse genome--additional polymorphisms among ten inbred mouse strains.
Fowlis GA, Adelman S, Knight AM, Simpson E
Mamm Genome. 1992
PubMed ID: 1611214
Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects.
Choi WH, O'Rahilly S, Buse JB, Rees A, Morgan R, Flier JS, Moller DE
Diabetes. 1991
PubMed ID: 1756912
Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus.
Kusari J, Verma US, Buse JB, Henry RR, Olefsky JM
J Clin Invest. 1991
PubMed ID: 1918382
Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat.
Slot JW, Geuze HJ, Gigengack S, James DE, Lienhard GE
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1881917
Intracellular targeting of the insulin-regulatable glucose transporter (GLUT4) is isoform specific and independent of cell type.
Haney PM, Slot JW, Piper RC, James DE, Mueckler M
J Cell Biol. 1991
PubMed ID: 1651337
Additional microsatellite markers for mouse genome mapping.
Hearne CM, McAleer MA, Love JM, Aitman TJ, Cornall RJ, Ghosh S, Knight AM, Prins JB, Todd JA
Mamm Genome. 1991
PubMed ID: 1794058
PCR-analyzed microsatellites: data concerning laboratory and wild-derived mouse inbred strains.
Montagutelli X, Serikawa T, Guénet JL
Mamm Genome. 1991
PubMed ID: 1794054
Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester.
Holman GD, Kozka IJ, Clark AE, Flower CJ, Saltis J, Habberfield AD, Simpson IA, Cushman SW
J Biol Chem. 1990
PubMed ID: 2211693
3T3-L1 adipocyte glucose transporter (HepG2 class): sequence and regulation of protein and mRNA expression by insulin, differentiation, and glucose starvation.
Reed BC, Shade D, Alperovich F, Vang M
Arch Biochem Biophys. 1990
PubMed ID: 2190533
Mouse insulin-responsive glucose transporter gene: characterization of the gene and trans-activation by the CCAAT/enhancer binding protein.
Kaestner KH, Christy RJ, Lane MD
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2404278
Polymorphic human insulin-responsive glucose-transporter gene on chromosome 17p13.
Bell GI, Murray JC, Nakamura Y, Kayano T, Eddy RL, Fan YS, Byers MG, Shows TB
Diabetes. 1989
PubMed ID: 2568955
Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues.
Fukumoto H, Kayano T, Buse JB, Edwards Y, Pilch PF, Bell GI, Seino S
J Biol Chem. 1989
PubMed ID: 2656669
Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes.
Kaestner KH, Christy RJ, McLenithan JC, Braiterman LT, Cornelius P, Pekala PH, Lane MD
Proc Natl Acad Sci U S A. 1989
PubMed ID: 2654938
Identification of a novel gene encoding an insulin-responsive glucose transporter protein.
Birnbaum MJ
Cell. 1989
PubMed ID: 2649253
A glucose transport protein expressed predominately in insulin-responsive tissues.
Charron MJ, Brosius FC, Alper SL, Lodish HF
Proc Natl Acad Sci U S A. 1989
PubMed ID: 2649883
Molecular cloning and characterization of an insulin-regulatable glucose transporter.
James DE, Strube M, Mueckler M
Nature. 1989
PubMed ID: 2645527

Model Organism Phenotype Links from MGI Top Help

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	Human	Mouse	Rat
Entrez Gene	6517	20528	25139
EnsEMBL Gene(s)	ENSG00000181856	ENSMUSG00000018566	ENSRNOG00000017226
Unigene	Hs.380691	Mm.10661	Rn.1314
Homologene	SLC2A4	Slc2a4	Slc2a4
OMIM	138190	N/A	N/A
GeneCards	SLC2A4	N/A	N/A
Beta Cell Genomics	DT.120957951 DT.409394 DT.95228304 DT.99934293	DT.532441 DT.91335589 DT.91411894	N/A
Reactome	P14672	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	6517	20528	25139

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Interactor	Interactor	Sources	Classification	Pubmed IDs
SLC2A4	ABI1	IntAct	empirical	16396496
SLC2A4	FARSB	IntAct	empirical	16396496
SLC2A4	SCAMP3	IntAct	empirical	16396496
SLC2A4	ARPC1B	IntAct	empirical	16396496
SLC2A4	ACTR3	IntAct	empirical	16396496
SLC2A4	CDH13	IntAct	empirical	16396496
SLC2A4	CDH15	IntAct	empirical	16396496
SLC2A4	PDIA6	HPRD, MINT, IntAct	empirical	16396496
SLC2A4	CDK2	IntAct	empirical	16396496
SLC2A4	FLOT1	IntAct	empirical	16396496
SLC2A4	STX6	IntAct	empirical	16396496
SLC2A4	BCKDK	IntAct	empirical	16396496
SLC2A4	RTN3	IntAct	empirical	16396496
SLC2A4	KBTBD10	HPRD, MINT, IntAct	empirical	16396496
SLC2A4	TUBA1B	IntAct	empirical	16396496
SLC2A4	TUBB3	IntAct	empirical	16396496
SLC2A4	TUBB4B	IntAct	empirical	16396496
SLC2A4	GNB2L1	IntAct	empirical	16396496
SLC2A4	CPQ	IntAct	empirical	16396496
SLC2A4	CDIPT	IntAct	empirical	16396496
SLC2A4	PGRMC2	IntAct	empirical	16396496
SLC2A4	LYPLA1	IntAct	empirical	16396496
SLC2A4	ACAA2	IntAct	empirical	16396496
SLC2A4	TIMM44	IntAct	empirical	16396496
SLC2A4	CAP1	IntAct	empirical	16396496
SLC2A4	SYNCRIP	IntAct	empirical	16396496
SLC2A4	GLRX3	IntAct	empirical	16396496
SLC2A4	DCTN2	IntAct	empirical	16396496
SLC2A4	PRDX4	IntAct	empirical	16396496
SLC2A4	ARL6IP5	IntAct	empirical	16396496
SLC2A4	ARPC1A	IntAct	empirical	16396496
SLC2A4	CCT4	IntAct	empirical	16396496
SLC2A4	CCT2	IntAct	empirical	16396496
SLC2A4	PAICS	IntAct	empirical	16396496
SLC2A4	LEPREL4	HPRD, MINT, IntAct	empirical	16396496
SLC2A4	PDLIM5	IntAct	empirical	16396496
SLC2A4	TXNIP	IntAct	empirical	16396496
SLC2A4	YKT6	IntAct	empirical	16396496
SLC2A4	GNA13	IntAct	empirical	16396496